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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HKZ2</accession>
    <name>A0A670HKZ2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein PNO1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HKZ2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000152.1">
        <property type="protein sequence ID" value="ENSPMRP00000000145.1"/>
        <property type="gene ID" value="ENSPMRG00000000092.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018052"/>
    <dbReference type="OMA" id="INESHNM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000048">
        <property type="entry name" value="RNA-binding protein PNO1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="6">
        <location>
            <begin position="73"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PNO1 second type I KH" evidence="7">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21067" checksum="E20DB9E9C7BB7256" modified="2020-06-17" version="1">MCTKQRNLSHRLIFKNEDAFQRRKQHACERQEGAMETAEGPPPLKRPDFPPLRREALGGGKGEVRKISVPPNRYTPLKENWMKIFTSIVEHLQLQIRFNLKTRNVEIKTCKQTKDVGALTKAVDFVKAFLLGFQVEDALALIRLDDLFLESFEVTDVKLLKGDHLSRAIGRIAGKGGKKNSLLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMI4</accession>
    <name>A0A670HMI4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HMI4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000563.1">
        <property type="protein sequence ID" value="ENSPMRP00000000535.1"/>
        <property type="gene ID" value="ENSPMRG00000000400.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57392">
        <property type="entry name" value="Defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025623872" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="67" mass="7601" checksum="97A38CFD09E40441" modified="2020-06-17" version="1">MNIVWLTMPFLFLFAGQTGFIETREACEAAEGWCQEGPCSIGPMEIGKCDTWIFCCTCSLVKTREWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMQ4</accession>
    <name>A0A670HMQ4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HMQ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000268.1">
        <property type="protein sequence ID" value="ENSPMRP00000000257.1"/>
        <property type="gene ID" value="ENSPMRG00000000176.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="OMA" id="QKESCEW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000383">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000902">
        <property type="entry name" value="Zinc finger protein 445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001767">
        <property type="entry name" value="Zinc finger protein 629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002196">
        <property type="entry name" value="zinc finger protein 850-like isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF377">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="493" mass="57033" checksum="FC693C7ACFF786C3" modified="2020-06-17" version="1">AQVWKQQQVPTVEEWQQTVMEYAEIARLMGGIRQQGDETFKKEWEKFMSYLGRIRTWEMEQHRPEHCGVVELLGSTKRNIPHCPVWGEGSGSPQQNPLKPYECSECGKCFRQHSQLVNHQGIHMGEKPYKCPECGKCFRQQSQLVKHQRIHTGEKPYKCAECGKCFRQHSQLGSHQRIHTGERPYACSDCGRAFSDPSHLNRHKRTHTGEKPCECSVCGKSFSTSAYLTTHMRIHTGEKPYQCSECGKSFNHNSGLLAHERIHRGEKPYKCPECGQSFSSRSVLIKHQRIHTGEKPFKCSICGKDFRQHSQLMNHERTHTGEKPFSCPDCGKSFGDPSHLIRHKRTHTRDRPYKCLACGKSFCTGNELLVHERTHTSDRPCRCSECGKCFRRRSALISHQRIHTGEKPYKCSECGKCFRERSPLVKHQRIHTGEKPYTCLECGKCFRQLSQLVNHRRIHTGERPFVCPECGRNFSDPSHLFRHKKIHLARETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMZ5</accession>
    <name>A0A670HMZ5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HMZ5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000368.1">
        <property type="protein sequence ID" value="ENSPMRP00000000347.1"/>
        <property type="gene ID" value="ENSPMRG00000000264.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286944"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF142">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF57.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="2">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="115" mass="12797" checksum="418550ACABEF8E9C" modified="2020-06-17" version="1">MGAEGKQRLWNQIRSGEAALWGQRPRDGAISWTGWAQRSGGRKQPGNQEGKTAQSRRSGVCFEDVAVRFTDEEWELLDPDQRALHKDVMEENWGIVASLGKAPLNQVFSSAAVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HN07</accession>
    <name>A0A670HN07_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HN07"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000718.1">
        <property type="protein sequence ID" value="ENSPMRP00000000680.1"/>
        <property type="gene ID" value="ENSPMRG00000000515.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234576"/>
    <dbReference type="OMA" id="CQQCQKC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003049">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000873">
        <property type="entry name" value="Zinc finger protein 841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000538">
        <property type="entry name" value="zinc finger protein 853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000642">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="29"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="141" mass="15982" checksum="E4E61080A83EC170" modified="2020-06-17" version="1">MCDFSEDQTAELKAAFQLCDRIEDGKILYCQLGEVMRALGQNPTNAEVMKVLGNPKSDEMNVKTLSFKQFLLLCTELNRIQINKDQGCFEDYVEGLRVFDQEGNRTVMGMTEEEVEMLAAGHEDSNGCIHYEELVRMVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HR01</accession>
    <name>A0A670HR01_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SLC9A7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HR01"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001606.1">
        <property type="protein sequence ID" value="ENSPMRP00000001507.1"/>
        <property type="gene ID" value="ENSPMRG00000000526.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153460"/>
    <dbReference type="OMA" id="NEHCWQY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002090">
        <property type="entry name" value="NHE-6/7/9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF62">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01088">
        <property type="entry name" value="NAHEXCHNGR6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="12 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025592533" description="Sodium/hydrogen exchanger" evidence="16">
        <location>
            <begin position="25"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="17">
        <location>
            <begin position="61"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="648"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="696" mass="77991" checksum="BBD4B8F84F9E390B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRU3</accession>
    <name>A0A670HRU3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein acetyltransferase BLOC1S1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HRU3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002063.1">
        <property type="protein sequence ID" value="ENSPMRP00000001940.1"/>
        <property type="gene ID" value="ENSPMRG00000001428.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002689"/>
    <dbReference type="OMA" id="WIGMMEN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="76" mass="8814" checksum="8D42F689F5AB4A40" modified="2020-06-17" version="1">VNQRKLDHEVKTLQIQAAQFAKQTGQWISMVENFNQALKEIGDVENWARSIEMDMRTIATALEYVYKGQLQPSTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HU78</accession>
    <name>A0A670HU78_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysosomal alpha-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Acid maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GAA</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPMRP00000003111.1"/>
        <property type="gene ID" value="ENSPMRG00000002215.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114589000"/>
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        <property type="component" value="Chromosome 2"/>
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    </dbReference>
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        <property type="term" value="C:lysosomal membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cardiac muscle contraction"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:glycophagy"/>
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    </dbReference>
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        <property type="term" value="P:heart morphogenesis"/>
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    </dbReference>
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        <property type="term" value="P:locomotory behavior"/>
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        <property type="term" value="P:lysosome organization"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:neuromuscular process controlling posture"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of the force of heart contraction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043181">
        <property type="term" value="P:vacuolar sequestering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000072">
        <property type="entry name" value="lysosomal alpha-glucosidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000005">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017957">
        <property type="entry name" value="P_trefoil_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF92">
        <property type="entry name" value="LYSOSOMAL ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00025">
        <property type="entry name" value="P_TREFOIL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="18">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="929" mass="104012" checksum="08AD217E063027A2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUY5</accession>
    <name>A0A670HUY5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="460"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="914" mass="104678" checksum="C800517A31618BA5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HVP7</accession>
    <name>A0A670HVP7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear receptor coactivator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NCOA1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the SRC/p160 nuclear receptor coactivator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028581052.1">
        <property type="nucleotide sequence ID" value="XM_028725219.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028581053.1">
        <property type="nucleotide sequence ID" value="XM_028725220.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000003860.1">
        <property type="protein sequence ID" value="ENSPMRP00000003601.1"/>
        <property type="gene ID" value="ENSPMRG00000002517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594932"/>
    <dbReference type="KEGG" id="pmua:114594932"/>
    <dbReference type="CTD" id="8648"/>
    <dbReference type="GeneTree" id="ENSGT00950000183021"/>
    <dbReference type="OMA" id="SRTCPQQ"/>
    <dbReference type="OrthoDB" id="10035882at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904017">
        <property type="term" value="P:cellular response to Thyroglobulin triiodothyronine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030520">
        <property type="term" value="P:estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042789">
        <property type="term" value="P:mRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050847">
        <property type="term" value="P:progesterone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002155">
        <property type="term" value="P:regulation of thyroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18948">
        <property type="entry name" value="bHLH-PAS_NCoA1_SRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000007">
        <property type="entry name" value="Nuclear receptor coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000031">
        <property type="entry name" value="Nuclear receptor coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000008">
        <property type="entry name" value="Nuclear receptor coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056193">
        <property type="entry name" value="bHLH_NCOA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010011">
        <property type="entry name" value="NCO_DUF1518"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028819">
        <property type="entry name" value="NCOA1_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009110">
        <property type="entry name" value="Nuc_rcpt_coact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014920">
        <property type="entry name" value="Nuc_rcpt_coact_Ncoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037077">
        <property type="entry name" value="Nuc_rcpt_coact_Ncoa_int_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017426">
        <property type="entry name" value="Nuclear_rcpt_coactivator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014935">
        <property type="entry name" value="SRC/p160_LXXLL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10684">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10684:SF1">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23172">
        <property type="entry name" value="bHLH_NCOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07469">
        <property type="entry name" value="DUF1518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16665">
        <property type="entry name" value="NCOA_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08815">
        <property type="entry name" value="Nuc_rec_co-act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08832">
        <property type="entry name" value="SRC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038181">
        <property type="entry name" value="Nuclear_receptor_coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01151">
        <property type="entry name" value="DUF1518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69125">
        <property type="entry name" value="Nuclear receptor coactivator interlocking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 16" id="KW-0010">Activator</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BHLH" evidence="19">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="18">
        <location>
            <begin position="108"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="370"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="529"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="657"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="705"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="861"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="903"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1213"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1327"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1480"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="437"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1231"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1245"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1494"/>
            <end position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR038181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1510" mass="161261" checksum="795B2E5C18F06BD3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HW96</accession>
    <name>A0A670HW96_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ACSL5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 14">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 14">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 14">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7 14">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13 14">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028586114.1">
        <property type="nucleotide sequence ID" value="XM_028730281.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586115.1">
        <property type="nucleotide sequence ID" value="XM_028730282.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586116.1">
        <property type="nucleotide sequence ID" value="XM_028730283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HW96"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004284.1">
        <property type="protein sequence ID" value="ENSPMRP00000004014.1"/>
        <property type="gene ID" value="ENSPMRG00000002749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597480"/>
    <dbReference type="KEGG" id="pmua:114597480"/>
    <dbReference type="CTD" id="51703"/>
    <dbReference type="GeneTree" id="ENSGT00940000156651"/>
    <dbReference type="OMA" id="IWHSYER"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090434">
        <property type="term" value="F:oleoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035338">
        <property type="term" value="P:long-chain fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010747">
        <property type="term" value="P:positive regulation of long-chain fatty acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="16">
        <location>
            <begin position="102"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="682" mass="75276" checksum="13F5A3B64F4C089F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWF3</accession>
    <name>A0A670HWF3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HWF3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003831.1">
        <property type="protein sequence ID" value="ENSPMRP00000003575.1"/>
        <property type="gene ID" value="ENSPMRG00000002499.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000209942"/>
    <dbReference type="OMA" id="MDNRMRL"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="1">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="114" mass="12689" checksum="3A1C1A270D2CA940" modified="2020-06-17" version="1">MFGCQSAGAAAKPAVMAWESDSEYPVALPEKFDGAPASFPMFLAQAKLYIQGRARNFPDDRTKVHFLISLLKDQAAKWALPLLRQDSPFLTDYMGFCNHLEAAFGNPQKESQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWK3</accession>
    <name>A0A670HWK3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger protein RFP-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ohanin/vespryn family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HWK3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003726.1">
        <property type="protein sequence ID" value="ENSPMRP00000003472.1"/>
        <property type="gene ID" value="ENSPMRG00000002428.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234669"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19762">
        <property type="entry name" value="Bbox2_TRIM7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16594">
        <property type="entry name" value="RING-HC_TRIM7-like_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="11">
        <location>
            <begin position="273"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034460"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51449" checksum="46F53315B55D5BD8" modified="2020-06-17" version="1">MADEGPVQNLCEETTCSICREYFTDPVIIDCGHIFCQSCITEAWGNSDQDASCPQCREPCQQRNVRPNRQLASIVEIVKKFSLQMARGVEALGKVCERHQEPLKLFCKDDQAPICVVCDKSKEHRDHKVIPKEEAFEEYQLFFRKEGRKEGRKEGRKEGRKEQVLNRAVHQPQTLSHQFLEEQERLLLAQLKELDNEIKSCEDQHIAKLSEEMSSIDDLIKELEEKQKQYQAISVWAGLANCEPESFEEVEQLPQEEASRWREIHTCTLPYNSNTDMAPSLCVCESLSLTVNIVLDPETANHYLILSEDGKSVRCGGERQNLPDSRKRFDPKTYVLGSERFRAVRKWWEVEVGGEKNGQVSLQPSVGIWAVGKAIVGSLYGLWAFTAPERTPLLLNHELRKIRVTLDYEKGSVGFLDVEGDVLIFTFPEASFFGEEIRPFFLVGQGAELSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HY23</accession>
    <name>A0A670HY23_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HY23"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004798.1">
        <property type="protein sequence ID" value="ENSPMRP00000004501.1"/>
        <property type="gene ID" value="ENSPMRG00000003078.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160090"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110158">
        <property type="term" value="C:calpain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735:SF3">
        <property type="entry name" value="CALPAIN SMALL SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735">
        <property type="entry name" value="CALPAIN, SMALL SUBUNIT 1 A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="114" mass="12527" checksum="89E780219A146508" modified="2020-06-17" version="1">MSSSEYPSQTDRSSKIMDTDFSGTIDAHEMRNALTEAGFTLNNKIQHSIALRYAGSKMTIDFDGFVACMIRLETLFNSAFDKTNTGTQMQKTFYPPQGLIGSAKGIDLQTSPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZR7</accession>
    <name>A0A670HZR7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Zinc transporter ZIP9</fullName>
            <shortName evidence="20">ZIP-9</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Solute carrier family 39 member 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Zrt- and Irt-like protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC39A9</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 20">Cell membrane</location>
            <topology evidence="5 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4 20">Cytoplasm</location>
            <location evidence="4 20">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 20">Golgi apparatus</location>
            <location evidence="3 20">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 20">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 20">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028581111.1">
        <property type="nucleotide sequence ID" value="XM_028725278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HZR7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005528.1">
        <property type="protein sequence ID" value="ENSPMRP00000005189.1"/>
        <property type="gene ID" value="ENSPMRG00000003563.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594969"/>
    <dbReference type="KEGG" id="pmua:114594969"/>
    <dbReference type="CTD" id="55334"/>
    <dbReference type="GeneTree" id="ENSGT00390000010094"/>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005497">
        <property type="term" value="F:androgen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022883">
        <property type="term" value="F:zinc efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000654">
        <property type="term" value="P:regulation of cellular response to testosterone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905562">
        <property type="term" value="P:regulation of vascular endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF5">
        <property type="entry name" value="ZINC TRANSPORTER ZIP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 20" id="KW-0813">Transport</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 20" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU369011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="307" mass="32150" checksum="F55CEE436B1266F9" modified="2020-06-17" version="1">MDDFLSISLLSLAMLVGCYVAGIIPLAVNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEAKHHPASETQKTVESEKAADVPVVHDHVHSHDHSRLHAYIGVSLVLGFVFMLLVDQIGSSHVHATDDPEAARSGNSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVLSMVTYLGLSKSSKQALSDVNATGVAMLFSAGTFLYVATVHVLPEVGGMGHSHKPDSTGGKGLSRLEVAALVLGCLIPLILSIGHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0H2</accession>
    <name>A0A670I0H2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I0H2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005776.1">
        <property type="protein sequence ID" value="ENSPMRP00000005424.1"/>
        <property type="gene ID" value="ENSPMRG00000003709.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="166" mass="18264" checksum="701D6CAAC046157F" modified="2020-06-17" version="1">RLNGQPDCLLYVELVWGQSSLPKLSVVYTDMLRCSTTELQLFPPAYTFASGTKTNTAKDPGKTEALSRRFGIIAALRDYGEKQRVGEKRKGHKGPLLDVGMGECGKVRLRDEILSVSGQWMVGVDIGSARISSEKTCGVLWRMTCNVFGEGVSSLSEKPCFTAFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1D3</accession>
    <name>A0A670I1D3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endothelin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Preproendothelin-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EDN3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Endothelins are endothelium-derived vasoconstrictor peptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the endothelin/sarafotoxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I1D3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006033.1">
        <property type="protein sequence ID" value="ENSPMRP00000005669.1"/>
        <property type="gene ID" value="ENSPMRG00000003851.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183053"/>
    <dbReference type="OMA" id="HSSKWPL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031708">
        <property type="term" value="F:endothelin B receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030072">
        <property type="term" value="P:peptide hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010460">
        <property type="term" value="P:positive regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046887">
        <property type="term" value="P:positive regulation of hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002690">
        <property type="term" value="P:positive regulation of leukocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045840">
        <property type="term" value="P:positive regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901381">
        <property type="term" value="P:positive regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048070">
        <property type="term" value="P:regulation of developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003100">
        <property type="term" value="P:regulation of systemic arterial blood pressure by endothelin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019229">
        <property type="term" value="P:regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014826">
        <property type="term" value="P:vein smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020475">
        <property type="entry name" value="Endothelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019764">
        <property type="entry name" value="Endothelin_toxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001928">
        <property type="entry name" value="Endothln-like_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13874">
        <property type="entry name" value="ENDOTHELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13874:SF11">
        <property type="entry name" value="ENDOTHELIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00322">
        <property type="entry name" value="Endothelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00365">
        <property type="entry name" value="ENDOTHELIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00272">
        <property type="entry name" value="END"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00270">
        <property type="entry name" value="ENDOTHELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0123">Cardiotoxin</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1213">G-protein coupled receptor impairing toxin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0800">Toxin</keyword>
    <keyword evidence="7" id="KW-0838">Vasoactive</keyword>
    <keyword evidence="10" id="KW-0839">Vasoconstrictor</keyword>
    <feature type="domain" description="Endothelin-like toxin" evidence="13">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Endothelin-like toxin" evidence="13">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="213" mass="24096" checksum="A5D728FB7BA77971" modified="2020-06-17" version="1">MYDFVFFLSICSTFPSLALFSGFSLPVSRPLLLYSGGSSSNSELRFPGPHGRVSKENETAVGGLLSAGNATVGKVAGPPEVHHRAKRCTCYTYKDKECVYYCHLDIIWINTPERIVPYGLANYRGSFRGKRSTERHRKSLHSSKQPPLRCSCADRCDKQCMHFCRRTQVGQCNNEQLNSREETDPHREKEHISHSVAQENFQLLQSGEVQSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3I8</accession>
    <name>A0A670I3I8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Iron-sulfur cluster transfer protein NUBPL</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nucleotide-binding protein-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NUBPL</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver one or more Fe-S clusters to complex I subunits.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I3I8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006846.1">
        <property type="protein sequence ID" value="ENSPMRP00000006424.1"/>
        <property type="gene ID" value="ENSPMRG00000004333.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183193"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000709">
        <property type="entry name" value="Iron-sulfur protein NUBPL isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="369" mass="39711" checksum="03AA521510B1C6AE" modified="2020-06-17" version="1">MCFSDFLSLAHPHFHSSLADPRLCCVNRPSHAANYPAILSCTHSSYTSGKLARFLFCFQSSNANDEVLKEKRSKIMARGLPKQKPIQGVKQVLVVASGKGGVGKSTTAVNVALALAANDSTKAVGLLDADVYGPSIPKMMNLKGSPEVTPKNLMRPLVNYGIACMSIGFLVEETAPIVWRGPMVMSAIEKLLRQVDWHQLDYLVIDMPPGTGDVQLSISQNIPIAGAVMVSTPQDIALLDARKGTEMFKKVNVPVLGLVQNMSLFQCPKCKHETHIFGTDGVRNLACDLGLDVLGDIPLHVHIRETSDAGKPIVVSQPQSDVKAFCLVPCNLAVKEPPEGPWRWISVSGLNDGGEDTPSGIQGQCHLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3U0</accession>
    <name>A0A670I3U0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 29 member 1 (Augustine blood group)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC29A1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028580197.1">
        <property type="nucleotide sequence ID" value="XM_028724364.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028580198.1">
        <property type="nucleotide sequence ID" value="XM_028724365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I3U0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006992.1">
        <property type="protein sequence ID" value="ENSPMRP00000006561.1"/>
        <property type="gene ID" value="ENSPMRG00000004433.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594536"/>
    <dbReference type="KEGG" id="pmua:114594536"/>
    <dbReference type="CTD" id="2030"/>
    <dbReference type="GeneTree" id="ENSGT00950000182898"/>
    <dbReference type="OMA" id="GMVVCWI"/>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015207">
        <property type="term" value="F:adenine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015212">
        <property type="term" value="F:cytidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015208">
        <property type="term" value="F:guanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015211">
        <property type="term" value="F:purine nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015389">
        <property type="term" value="F:pyrimidine- and adenosine-specific:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015210">
        <property type="term" value="F:uracil transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015213">
        <property type="term" value="F:uridine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032238">
        <property type="term" value="P:adenosine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046032">
        <property type="term" value="P:ADP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035344">
        <property type="term" value="P:hypoxanthine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035340">
        <property type="term" value="P:inosine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001504">
        <property type="term" value="P:neurotransmitter uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035364">
        <property type="term" value="P:thymine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034764">
        <property type="entry name" value="ENT1/ENT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00939">
        <property type="entry name" value="2a57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF9">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="456" mass="50500" checksum="5E2610FE42DDE6AB" modified="2020-06-17" version="1">MTGNSPQDRYKAVWLIFFILGLGTLLPWNFFMTATGYFTSRLNEDTYNNVSSIDLHMNMNDTETEKPPPTHLQSIFNNVMTLCAMLPLLIFTCLNSFIHQRIPQQVRILCSLVAILLVFLITAIVVKISMAPLSFFTITMVKIVFINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGTFAALAMICALASGSKLEDSAFGYFITACVVILMAIGAYIMLPRLDFFRYYSMKDKTEYRTHEAYSEVETKMDLIKKDDLNGVEPPHAANGASRAPDHNPSVLSIFKKIWAMAACVCFVFTVTIGVFPAVTADVKPTIAGKTLWADYFIPVCCFLTFNVFDWAGRSLTAVCMWPGKDSRLLPIMVVARVVFIPLFMLCNVDPRRHLPVLFAHDAWYIVFMFFFSISNGYLASLCMCFGPKKVLSHEAETAGTIMAFFLSLGLALGAVLSFPIRLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6H4</accession>
    <name>A0A670I6H4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Doublesex- and mab-3-related transcription factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114598979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028589274.1">
        <property type="nucleotide sequence ID" value="XM_028733441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I6H4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007818.1">
        <property type="protein sequence ID" value="ENSPMRP00000007303.1"/>
        <property type="gene ID" value="ENSPMRG00000004948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598979"/>
    <dbReference type="KEGG" id="pmua:114598979"/>
    <dbReference type="GeneTree" id="ENSGT00940000156282"/>
    <dbReference type="OMA" id="ECCSEIN"/>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF123">
        <property type="entry name" value="DOUBLESEX-AND MAB-3-RELATED TRANSCRIPTION FACTOR 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="8">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="6">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="388" mass="44273" checksum="5700007BB332C885" modified="2020-06-17" version="1">MLPLPSRRQRKAKPARPVNSSELPGHEGEGGCGAFSTVSRRLLSQRLPKCARCRNHGVVSSLKGHKRLCRWRECACAACLLVLERQRVTAAQVALRRRQDQVAGQVKKGMKSSECSVSGHRLNFHCKTKQTARLLARHSPEANSPPSQETEHCLSSLSERMRKRRAFADKELESIMLERELRQRTFDGFAAHQRRQLLSREHLPALEENVFQSGHDYLNYLTCVNSGMLNICFPLLHSNTKVLDYGPCIYKITDTSPLNVAFITASQTEGGTSQKRTCEENMNKYLNVYRENNCDWKEQALSSVFSRDLLLLENNWSPKIIKLQENKELRDMAARYCILCNHHSKQENHNVNDTGLEVKEDVRHLSQECCSEINKQILSFSVESLLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8L7</accession>
    <name>A0A670I8L7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger and BTB domain containing 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZBTB42</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028604043.1">
        <property type="nucleotide sequence ID" value="XM_028748210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I8L7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008587.1">
        <property type="protein sequence ID" value="ENSPMRP00000008031.1"/>
        <property type="gene ID" value="ENSPMRG00000005440.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606212"/>
    <dbReference type="KEGG" id="pmua:114606212"/>
    <dbReference type="CTD" id="100128927"/>
    <dbReference type="GeneTree" id="ENSGT00940000155092"/>
    <dbReference type="OMA" id="HPPCILQ"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18325">
        <property type="entry name" value="BTB_POZ_ZBTB18_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004119">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000114">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000220">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000021">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF20">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="496" mass="54245" checksum="7083E8B49651AC30" modified="2020-06-17" version="1">MSPSTPCSAAVQGYEGRMEFPDHSRQLLQCLSQQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFGLLLEFMYQGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDKELCVDEKTNGSGGAHSEKDGRVLDDGVPLGHGEFSPGEKYKMIAAEYERSAGKDKGSSYPGWSPDLAGSVLGEAELDTVAAEKARANVSSLAGPVSQRPPRHPLALREAECALDLSFKPLSGRDGFQPSYIFGQLAADGPPRQGSEPFVKDEEESLSDGEDGEERGLESQGFGNSGQSLALGLGTMFVASNGDAPVTPEEDVDQEREASEDDMASSDVSSSGVVVPTGHICICPLCSKVFPSPHVLQLHLSSHFRDKDGSRTRLSPDGSVPTCTLCGKTFSCMYTLKRHERTHSGEKPYTCGQCGKSFQYSHNLSRHAVVHTREKPHGCKWCERRFTQSGDLYRHIRKFHCGLVKSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8Z1</accession>
    <name>A0A670I8Z1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ heat shock protein family (Hsp40) member B12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DNAJB12</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028585426.1">
        <property type="nucleotide sequence ID" value="XM_028729593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I8Z1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008851.1">
        <property type="protein sequence ID" value="ENSPMRP00000008275.1"/>
        <property type="gene ID" value="ENSPMRG00000005610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597252"/>
    <dbReference type="CTD" id="54788"/>
    <dbReference type="GeneTree" id="ENSGT00940000155590"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000004">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily B, member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF8">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="109"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="414" mass="46926" checksum="FC56F54AB3CC2619" modified="2020-06-17" version="1">MESNRDEAERCIAIAVGAIKAGQVEKARRFLEKAQRLYPSQRVRVLLDSLTRSEKSSNGHSQTKESTNPHLRKMSGDIPAANGEAGGDISKGYTQDQVDAVKRVKQCKDYYEILGVSRDSSDEDLKKAYRKLALKFHPDKNHAPGATEAFKAIGNAYAVLSNPEKRKQYDQFGDAKVSPTRHGHSPTDFNRGFEADISPEDLFNMFFGGGFPSSPTLNREPKGRRHRECTVSACSRKPPRVVESAWRERRGEPRNVHVYSNGRMRYTYHQRQDRREHQGDGGLGLFVQLMPILILIIVSALSQMMVSSPPYSLSHRPSVGHIYKRTTEHLKVSYFVADNFAEEYTGTNLKNVERSVEDDYIANLRNNCWKEKQQKEGLLYRARYFGDSDLYQRAQKMGTPSCSRLSEVQASMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I933</accession>
    <name>A0A670I933_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Troponin T3, fast skeletal type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TNNT3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the troponin T family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I933"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008902.1">
        <property type="protein sequence ID" value="ENSPMRP00000008325.1"/>
        <property type="gene ID" value="ENSPMRG00000005639.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158477"/>
    <dbReference type="OMA" id="EMHQRIC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030172">
        <property type="term" value="F:troponin C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031013">
        <property type="term" value="F:troponin I binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006942">
        <property type="term" value="P:regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000001">
        <property type="entry name" value="Troponin T, fast skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF4">
        <property type="entry name" value="TROPONIN T, FAST SKELETAL MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="299" mass="35563" checksum="96049BD1062E0921" modified="2020-06-17" version="1">IKGVFIFREFLSFVSVLVVHVLQLLCFFVDSVAFLVFFLSFFYPNAEEYEEEEEAQEEEEAQEEVHEPVHEPEVQEEKKPRVVPPLTAPKIPEGEKVDFDDIQKKRQNKDLIELQALIDSHFEARKKEEEEILALKERIEKRRAERAEQQRIRAEKEKERQARLAEEKARREEEDAKRRAEDDMKKKKALSSMGATYSSYLAKADQKRGKKQTARELKKKVLAERRKPLNIDHLSEDKLREKAKEMWDWLYQLETEKYEYLEKIKRQKYDITTLRNRIDQAQKHSKKAGAKGKVGGRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9N4</accession>
    <name>A0A670I9N4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aly/REF export factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ALYREF</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I9N4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009181.1">
        <property type="protein sequence ID" value="ENSPMRP00000008590.1"/>
        <property type="gene ID" value="ENSPMRG00000005805.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00410000025615"/>
    <dbReference type="OMA" id="NEFGPIK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <location>
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        </location>
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        <location>
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        <location>
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            <begin position="20"/>
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    <sequence length="329" mass="34825" checksum="409A579B90A89394" modified="2020-06-17" version="1">MGDKMDMSLDDIIKLNRSQRGGGGRAGGGRGRGRGAAGRGGGAGRGGAGRAGGGGPVRNRGALSRGGGRNRPAPYSRPKQLPEKWQHDLFESGFGAGAGVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIDTQRRPIQSVNRGGMTRNRGGSGGFGGGSRRGSRGNRGRGRGAGRSSKQQLSAEELDAQLDAYNARVIVAEMAEQEPTPEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGNVAIAVGESLEDVFGPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9Q4</accession>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
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        <property type="entry name" value="UPAR/LY6 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00087"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="127" mass="13789" checksum="0D36FEDAADEA6008" modified="2020-06-17" version="1">TGLNRSGVLYLVLPWSSSQALRCYSCPEPITAVKCMKVDNCLQNETMCKTTMYSREEVYPFQGDSTVTRSCSSRCIPSDVDGIGLTRPVTCCNTDLCNHDGAASVQISYITVGTSAASFFILLRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IC44</accession>
    <name>A0A670IC44_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RFX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Regulatory factor X 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RFX6</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
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                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028579089.1">
        <property type="nucleotide sequence ID" value="XM_028723256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IC44"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009882.1">
        <property type="protein sequence ID" value="ENSPMRP00000009258.1"/>
        <property type="gene ID" value="ENSPMRG00000006227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594083"/>
    <dbReference type="CTD" id="222546"/>
    <dbReference type="GeneTree" id="ENSGT01050000244879"/>
    <dbReference type="OMA" id="FAKNWEH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003310">
        <property type="term" value="P:pancreatic A cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003311">
        <property type="term" value="P:pancreatic D cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090104">
        <property type="term" value="P:pancreatic epsilon cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003309">
        <property type="term" value="P:type B pancreatic cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000211">
        <property type="entry name" value="Regulatory factor X, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF28">
        <property type="entry name" value="DNA-BINDING PROTEIN RFX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="11">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="928" mass="102605" checksum="6F182D627882A557" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICI5</accession>
    <name>A0A670ICI5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670ICI5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009943.1">
        <property type="protein sequence ID" value="ENSPMRP00000009317.1"/>
        <property type="gene ID" value="ENSPMRG00000006271.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000248530"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF30">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="501"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1167" mass="130930" checksum="87C686969F7BA270" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDY3</accession>
    <name>A0A670IDY3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transforming growth factor beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TGFB3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3. Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 16">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028575010.1">
        <property type="nucleotide sequence ID" value="XM_028719177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IDY3"/>
    <dbReference type="SMR" id="A0A670IDY3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010799.1">
        <property type="protein sequence ID" value="ENSPMRP00000010135.1"/>
        <property type="gene ID" value="ENSPMRG00000006766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591728"/>
    <dbReference type="KEGG" id="pmua:114591728"/>
    <dbReference type="CTD" id="7043"/>
    <dbReference type="GeneTree" id="ENSGT00940000155747"/>
    <dbReference type="OMA" id="SHMKMYV"/>
    <dbReference type="OrthoDB" id="6092228at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034713">
        <property type="term" value="F:type I transforming growth factor beta receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005114">
        <property type="term" value="F:type II transforming growth factor beta receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034714">
        <property type="term" value="F:type III transforming growth factor beta receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070483">
        <property type="term" value="P:detection of hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060325">
        <property type="term" value="P:face morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010936">
        <property type="term" value="P:negative regulation of macrophage cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904706">
        <property type="term" value="P:negative regulation of vascular associated smooth muscle cell proliferation"/>
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        <property type="term" value="P:positive regulation of cell division"/>
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        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="term" value="P:positive regulation of collagen biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of epithelial to mesenchymal transition"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of protein secretion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of stress fiber assembly"/>
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        <property type="term" value="P:response to progesterone"/>
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        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Transforming growth factor beta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transforming growth factor beta"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cystine-knot cytokines"/>
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        <property type="entry name" value="Cystine-knot_cytokine"/>
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        <property type="entry name" value="TGF-b_propeptide"/>
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        <property type="entry name" value="TGF-beta"/>
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        <property type="entry name" value="TGF-beta-rel"/>
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        <property type="entry name" value="TGFb_CS"/>
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    </dbReference>
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        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA-3 PROPROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00019">
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        <property type="entry name" value="TGF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01423">
        <property type="entry name" value="TGFBETA"/>
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        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14 16" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11 14" id="KW-0497">Mitogen</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025720524" description="Transforming growth factor beta" evidence="14">
        <location>
            <begin position="22"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="17">
        <location>
            <begin position="296"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="343"/>
            <end position="408"/>
        </location>
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            <begin position="347"/>
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        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="15">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
    <sequence length="411" mass="47193" checksum="AB1D1ED95DCE7CF7" modified="2020-06-17" version="1">MHLHRALLLLSLLSLATVSLSLSSCTTLDLEHIKKKRVEAIRGQILSKLRLTSPPETVGPSHVPYQILALYNSTRELLEEMEEEKEESCSQDHTESEYYAKEIHKFDMIQGFPEHNELTYCPKGVTSNLFRFNVSSAEKNSTNLFRAEFRVLRVPNLSSKRTEQRIELFQILKPDEHIAKQRYLSGRNVMTRGSPEWLSFDVTDTVREWLLHRESNLGLEISIHCPCNTFQSNGDILENLHEVLEIKFKGIESEDSHVGRGDLGSLKKQKDLHNPHLILMMLPPHRLGSPALRSQRKKRALDTNYCFRNMEENCCVRRLYIDFRQDLGWKWVHEPKGYFANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFP8</accession>
    <name>A0A670IFP8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IFP8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011255.1">
        <property type="protein sequence ID" value="ENSPMRP00000010551.1"/>
        <property type="gene ID" value="ENSPMRG00000007013.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000475"/>
    <dbReference type="OMA" id="LYSACQH"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="121" mass="13978" checksum="8400EDBEC8654AAB" modified="2020-06-17" version="1">MAEVEQKKHTFRKFTCRGVDLDQLLGMSYKQLIQLYSACQHQRLNRGLRRKQHSLLKWLCKAKKEALPMEKPEVVKTYLRPMIILPELVGSMVGVYNGKTFNQVEIKPEMIGDLGSIVSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IG03</accession>
    <name>A0A670IG03_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mas-related G-protein coupled receptor member H-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114601258</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family. Mas subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028594308.1">
        <property type="nucleotide sequence ID" value="XM_028738475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IG03"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011308.1">
        <property type="protein sequence ID" value="ENSPMRP00000010599.1"/>
        <property type="gene ID" value="ENSPMRG00000007051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601258"/>
    <dbReference type="KEGG" id="pmua:114601258"/>
    <dbReference type="GeneTree" id="ENSGT01030000234639"/>
    <dbReference type="OMA" id="CEGLLAF"/>
    <dbReference type="OrthoDB" id="9631784at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000193">
        <property type="entry name" value="Mas-related G-protein coupled receptor member E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026234">
        <property type="entry name" value="MRGPCRFAMILY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11334:SF68">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11334">
        <property type="entry name" value="MAS-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02108">
        <property type="entry name" value="MRGPCRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="60"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="326" mass="36386" checksum="B022EFBF9AF4BB43" modified="2020-06-17" version="1">MAEQSTATSHGLTTDGFSGDYSPSAFPEEDAESELASFTYYLLLFFFLFMLTIFICGLVGNAIVIWFLCFIVKKNPITTYILNLAVADSCVLVTLAFSISARFWDVGGISSGLGFELFTSTHAISLYLLTAISSEKCLSVVFPIWYRCHRLEHLSEIVCALIWAMSILVFGIYNFFILTESADFDIVICVVHMISSVFCTLVVVICTVILFIKVCCSLHRRQRGKFYTALLLALLFFLIFGVPLSVIITVQCLLADINIITALFGVVSAVINSSVNPFIYFLIGRKKMHRSREPLKVVLERVFSDKADCREDQSLPATTDSMMMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHZ6</accession>
    <name>A0A670IHZ6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IHZ6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011991.1">
        <property type="protein sequence ID" value="ENSPMRP00000011224.1"/>
        <property type="gene ID" value="ENSPMRG00000007502.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018141"/>
    <dbReference type="OMA" id="THARDRC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF85">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="344" mass="39173" checksum="90D62D893A794E76" modified="2020-06-17" version="1">MDKGNRHIKVMTLEDEPLRSEGVQHATGEERRASTSRSRADEAAGPKPKGHSVADMPGSERKVQCCKEKYCIGTWNVRTMNLGKLEVVKNEMARINIDILGISELKWTGMDEFSLDDHHIYYCGQESHKRNGVALIVNKRVARAVLGCNLKNDRMISIQFQGRPFNITVIQVYAPTTGAEETEIDQFYEDLQHLIEMTPKKDVLLVIGDWNAKVGNQEIKGTTGKFGLGIQNEAGQRLIEFCQENKLVITNTLFQQHKRRLYTWTSPDGQHRNQIDYILCSQRWKSSIQSAKTKPGADCGSDLLIAKFKLKLKEVGKTTGLVRYNLSQIPYEYTVEVRNRFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIK0</accession>
    <name>A0A670IIK0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sesquipedalian</fullName>
            <shortName evidence="9">Ses</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PH domain-containing endocytic trafficking adaptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PHETA1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 9">Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Recycling endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus</location>
            <location evidence="2 9">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the sesquipedalian family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IIK0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012689.1">
        <property type="protein sequence ID" value="ENSPMRP00000011885.1"/>
        <property type="gene ID" value="ENSPMRG00000007937.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162791"/>
    <dbReference type="OMA" id="FECTRAR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13288">
        <property type="entry name" value="PH_Ses"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sesquipedalian-1 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF53">
        <property type="entry name" value="INOSITOL PHOSPHATASE INTERACTING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="213" mass="23876" checksum="016796D788678478" modified="2020-06-17" version="1">MKLNERSVAFYATCDAPADNAGFLYKKGERNTAYHRRWFVLRGNMLFYFEDRESREPVGVVILEGCTVELCESTEEFAFAIRFDCAKSRTYVLAAESQAAMESWVKALSRASFGYLRLLVRELEKQLEEMQKDLLPEKPSVPICIPAKENGCALWYNSEGPTSLPGGRALSGNSCSSEGSGSPSCFSRLHDSYGREVLELRRAWLEGQKDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIX5</accession>
    <name>A0A670IIX5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IIX5"/>
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        <property type="protein sequence ID" value="ENSPMRP00000011506.1"/>
        <property type="gene ID" value="ENSPMRG00000007706.1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="76" mass="8641" checksum="A5DDF111FFFB93A8" modified="2020-06-17" version="1">MKVFKGCNCVNWLSPLSSSKHLTEGCFPCLPCFLHNHLVFTYILASVAFLKTLFVSFTFLVRIILKIRNPSVKHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJ14</accession>
    <name>A0A670IJ14_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">(E3-independent) E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="13">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E2/E3 hybrid ubiquitin-protein ligase UBE2O</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ubiquitin carrier protein O</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 O</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin-conjugating enzyme E2 of 230 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ubiquitin-protein ligase O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">UBE2O</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain). Interacts with UBR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.24" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028572837.1">
        <property type="nucleotide sequence ID" value="XM_028717004.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000012865.1">
        <property type="protein sequence ID" value="ENSPMRP00000012050.1"/>
        <property type="gene ID" value="ENSPMRG00000008042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114590650"/>
    <dbReference type="KEGG" id="pmua:114590650"/>
    <dbReference type="CTD" id="63893"/>
    <dbReference type="GeneTree" id="ENSGT00940000160755"/>
    <dbReference type="OMA" id="WVKGFED"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030513">
        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000045">
        <property type="entry name" value="Ubiquitin conjugating enzyme E2 O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057732">
        <property type="entry name" value="SH3-A_UBE2O"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057733">
        <property type="entry name" value="UBE2O-like_SH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057734">
        <property type="entry name" value="UBE2O-like_SH3-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057735">
        <property type="entry name" value="UBE2O-like_tSH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23048">
        <property type="entry name" value="SH3-A_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23043">
        <property type="entry name" value="SH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23044">
        <property type="entry name" value="SH3-C_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23046">
        <property type="entry name" value="tSH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="22">
        <location>
            <begin position="962"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="496"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="733"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="893"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1234"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="64"/>
            <end position="100"/>
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        <location>
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        <location>
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        </location>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077504"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081850"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
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            <dbReference type="Ensembl" id="ENSPMRP00000012050.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    <sequence length="1330" mass="145335" checksum="4E19E510304DEA33" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKC7</accession>
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        <recommendedName>
            <fullName evidence="4">Centromere protein T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CENPT</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Identified in a centromeric complex containing histones H2A, H2B, H3 and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Interacts (via N-terminus) with the NDC80 complex. Heterodimer with CENPW; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-T/CNN1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_028739730.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000012034.1"/>
        <property type="gene ID" value="ENSPMRG00000008037.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114602016"/>
    <dbReference type="CTD" id="80152"/>
    <dbReference type="GeneTree" id="ENSGT00390000003044"/>
    <dbReference type="OMA" id="YFQHLCN"/>
    <dbReference type="OrthoDB" id="10071681at2759"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16171">
        <property type="entry name" value="CENP-T_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere kinetochore component CENP-T N-terminal" evidence="17">
        <location>
            <begin position="90"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="16">
        <location>
            <begin position="767"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="531"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="747"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="563"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="614"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="639"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010137"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016401"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="877" mass="97588" checksum="C6D314079F0B1B4D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKF7</accession>
    <name>A0A670IKF7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized LOC114603535</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114603535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IKF7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012951.1">
        <property type="protein sequence ID" value="ENSPMRP00000012131.1"/>
        <property type="gene ID" value="ENSPMRG00000008110.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="OMA" id="RSHQMEL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="5">
        <location>
            <begin position="540"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="630"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="790"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="931" mass="102195" checksum="0810F92558B7206B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IL44</accession>
    <name>A0A670IL44_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Interferon regulatory factor 2 binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">IRF2BP1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IRF2BP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028597940.1">
        <property type="nucleotide sequence ID" value="XM_028742107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IL44"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013586.1">
        <property type="protein sequence ID" value="ENSPMRP00000012720.1"/>
        <property type="gene ID" value="ENSPMRG00000008505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603251"/>
    <dbReference type="KEGG" id="pmua:114603251"/>
    <dbReference type="CTD" id="26145"/>
    <dbReference type="GeneTree" id="ENSGT00940000162120"/>
    <dbReference type="OMA" id="MFQDCLK"/>
    <dbReference type="OrthoDB" id="10065080at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16715">
        <property type="entry name" value="vRING-HC_IRF2BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1580:FF:000001">
        <property type="entry name" value="interferon regulatory factor 2-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1580">
        <property type="entry name" value="Interferon regulatory factor 2-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044882">
        <property type="entry name" value="I2BP1/2_C3HC4-RING_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058682">
        <property type="entry name" value="IRF-2BP1/2-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022750">
        <property type="entry name" value="IRF-2BP1_2-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057414">
        <property type="entry name" value="Zf-C3HC4_IRF-2BP1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF17">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11261">
        <property type="entry name" value="IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25457">
        <property type="entry name" value="IRF-2BP1_2_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25454">
        <property type="entry name" value="zf-C3HC4_IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like zinc finger" evidence="5">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="IRF-2BP1/2-like middle" evidence="7">
        <location>
            <begin position="188"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like C3HC4 zinc finger" evidence="6">
        <location>
            <begin position="519"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="602" mass="64171" checksum="011A66CAB68CAF0A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IMM0</accession>
    <name>A0A670IMM0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TANC1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TANC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028602328.1">
        <property type="nucleotide sequence ID" value="XM_028746495.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000013846.1">
        <property type="protein sequence ID" value="ENSPMRP00000012966.1"/>
        <property type="gene ID" value="ENSPMRG00000008679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605339"/>
    <dbReference type="KEGG" id="pmua:114605339"/>
    <dbReference type="CTD" id="85461"/>
    <dbReference type="GeneTree" id="ENSGT00940000155655"/>
    <dbReference type="OMA" id="QGPDARM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097062">
        <property type="term" value="P:dendritic spine maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008542">
        <property type="term" value="P:visual learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <source>
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    <sequence length="1857" mass="203956" checksum="5ACDF962C19EB9D0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Podarcis muralis</name>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INZ1</accession>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15155" checksum="4F0523B30A744581" modified="2020-06-17" version="1">MGWYLQTWINQFLKTNGLPKVTQEKRTILNCKITQQEIEGAIQNMQLGKSPGPDGLTSKYYKTLKDYLIQPLMEVCNQIMEGKKAPESWKEAFITLIPKVETEKTQLKNYRPISLLNVDYKIFADILASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IPN8</accession>
    <name>A0A670IPN8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IPN8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015085.1">
        <property type="protein sequence ID" value="ENSPMRP00000014118.1"/>
        <property type="gene ID" value="ENSPMRG00000009379.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160625"/>
    <dbReference type="OMA" id="YDKQGGG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cristae formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF7">
        <property type="entry name" value="AFG3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="276"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="695"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="729" mass="80596" checksum="39B5376D3F09691A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQI0</accession>
    <name>A0A670IQI0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nectin cell adhesion molecule 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NECTIN3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:apical junction complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098631">
        <property type="term" value="F:cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090103">
        <property type="term" value="P:cochlea morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0061951">
        <property type="term" value="P:establishment of protein localization to plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002089">
        <property type="term" value="P:lens morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902414">
        <property type="term" value="P:protein localization to cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150052">
        <property type="term" value="P:regulation of postsynapse assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060042">
        <property type="term" value="P:retina morphogenesis in camera-type eye"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000511">
        <property type="entry name" value="Nectin cell adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF12">
        <property type="entry name" value="NECTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="300" mass="34397" checksum="FA5FB0DD34ADCDFC" modified="2020-06-17" version="1">MVFHSSLRLYMFVDSPEVTVTGYDGNWYIGRENVLLRCNADANPLPMEFTWSRLDRHWPEGLQPLNNTLHFNSPLTYNYTGTYVCTVANPLGQKSDQKTIYILDPPTTTTSPPTIPWLPSTDGITGLATQPKLKLFPTSPWPAMQEDNWGTIIGSAVGGALFLIFVCVLAGVILYRRRRTFRGDYFAKNYIPPSDMQKESQIDTLQVEDVDSYPDSVKKEIKHPVNSHITKDYLGESEKTDWNKVDTINRYQDRYERPMDYYEGGTLGMKYLGEECYEENEDDLVSHVDGSVISRKEWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQQ4</accession>
    <name>A0A670IQQ4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Spire type actin nucleation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SPIRE2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the spire family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IQQ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015300.1">
        <property type="protein sequence ID" value="ENSPMRP00000014325.1"/>
        <property type="gene ID" value="ENSPMRG00000009554.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003058"/>
    <dbReference type="OMA" id="IPHACSG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22186">
        <property type="entry name" value="WH2_Spire1-2_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22079">
        <property type="entry name" value="WH2_Spire2_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22081">
        <property type="entry name" value="WH2_Spire2_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22065">
        <property type="entry name" value="WH2_Spire_1-2_r1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF5">
        <property type="entry name" value="PROTEIN SPIRE HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16474">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00750">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KIND" evidence="16">
        <location>
            <begin position="40"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="456"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="745" mass="81898" checksum="859CE72D46045B03" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IR21</accession>
    <name>A0A670IR21_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 335</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZNF335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSPMRT00000014908.1">
        <property type="protein sequence ID" value="ENSPMRP00000013949.1"/>
        <property type="gene ID" value="ENSPMRG00000009342.1"/>
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        <property type="entry name" value="ZINC FINGER PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF36">
        <property type="entry name" value="ZINC FINGER PROTEIN 335"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
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    <feature type="domain" description="C2H2-type" evidence="7">
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            <end position="624"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7">AP-4 complex subunit mu-1</fullName>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="7">Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.</text>
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        <subcellularLocation>
            <location evidence="7">Early endosome</location>
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        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">trans-Golgi network membrane</location>
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        <subcellularLocation>
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            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
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        <property type="term" value="F:protein domain specific binding"/>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="entry name" value="AP_mu_sigma_su"/>
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        <property type="entry name" value="Clathrin_mu"/>
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    </dbReference>
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        <property type="entry name" value="MHD"/>
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    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="169"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="431" mass="47550" checksum="ED18D51AE5130F9C" modified="2020-06-17" version="1">MVEKRAGGRGLCRARGSGSPLTDPPLLLLPSLQQARQGLHFAHVRHAGLYFVVTVLPNASPFAAVEFLNRLVTLLRDYCGSLSEKTVSLNFALIYELLDELLDYGYIQTTAPDVLKNFIQMEPVLSQPFSLLDLSTVGLFGADTQQSKVAPSCAAARPVLSLRGEQSSRPEVFLDVVERLTVIIAANGTPMKTDIQGEIHLKSFFPGCSEMRVGLTEEFCVGKTELRGYGTTVRVDECSFHSSVKLDEFERSRILRVNPSQGELTLMQYQLADDTPAALPFHLFPTINHDPSGRVQIYLKLRCDLSPKSHAVNIHLHLPVPKATLSLSQELSSPEQSATFQPSKKSIEWVIPRVQGGSQLSALFKLEVPGLSRARLLELGPANLSFEVPAHTSSGLQIRFLRFVGPQPSLPHRWVRYVTHSDSYVIRLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRM9</accession>
    <name>A0A670IRM9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IRM9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014805.1">
        <property type="protein sequence ID" value="ENSPMRP00000013852.1"/>
        <property type="gene ID" value="ENSPMRG00000009290.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="OMA" id="HPWAKEE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000122">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002357">
        <property type="entry name" value="Zinc finger protein 782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="487"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="552" mass="60708" checksum="01EDCEFD954332F3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISE3</accession>
    <name>A0A670ISE3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neurotrypsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine protease 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PRSS12</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028599884.1">
        <property type="nucleotide sequence ID" value="XM_028744051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ISE3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016073.1">
        <property type="protein sequence ID" value="ENSPMRP00000015043.1"/>
        <property type="gene ID" value="ENSPMRG00000010040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604178"/>
    <dbReference type="KEGG" id="pmua:114604178"/>
    <dbReference type="CTD" id="8492"/>
    <dbReference type="GeneTree" id="ENSGT00940000158131"/>
    <dbReference type="OMA" id="GPIHADN"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
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        <source>
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    <sequence length="843" mass="93060" checksum="7F6D4009EA815B33" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXL1</accession>
    <name>A0A670IXL1_PODMU</name>
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        <recommendedName>
            <fullName evidence="9">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="primary">MAF1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MAF1 family.</text>
    </comment>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="term" value="F:RNA polymerase III core binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="Maf1"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="255" mass="28762" checksum="84ABBA99164DD5BC" modified="2020-06-17" version="1">MKLLENSSFEALNSQLTVETGDAHIIGRIESYSCKMAGDDKHLFKQFCQEGQPHVLEALSPPQTTGISPSRLSKSQSGDEEGPLSDKCSRKTLFYLIATLNESFRPDYDFSAAKSHEFSREPSLNWVVNAVNCSLFSAVREDFSALKPHLWDAVDQEICLSECDIYSYNPDLDSDPFGEEGSLWSFNYFFYNKRLKRIVFFTCRSISGSTYPHPEAGNELNMDLSEDDAEEEEAAGPRDEDGASLEEDRRQVICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IYQ9</accession>
    <name>A0A670IYQ9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Regulator of nonsense transcripts 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Up-frameshift suppressor 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UPF2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000018251.1">
        <property type="protein sequence ID" value="ENSPMRP00000017135.1"/>
        <property type="gene ID" value="ENSPMRG00000011357.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064318"/>
    <dbReference type="OMA" id="DFQHHQI"/>
    <dbReference type="Proteomes" id="UP000472272">
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    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031100">
        <property type="term" value="P:animal organ regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Putative regulator of nonsense transcripts 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.160:FF:000002">
        <property type="entry name" value="Putative regulator of nonsense transcripts 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000015">
        <property type="entry name" value="regulator of nonsense transcripts 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000023">
        <property type="entry name" value="regulator of nonsense transcripts 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="12">
        <location>
            <begin position="263"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="12">
        <location>
            <begin position="685"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="12">
        <location>
            <begin position="889"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="254"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="674"/>
        </location>
    </feature>
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        <location>
            <begin position="1136"/>
            <end position="1215"/>
        </location>
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        <location>
            <begin position="1342"/>
            <end position="1378"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
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            <begin position="99"/>
            <end position="241"/>
        </location>
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            <end position="608"/>
        </location>
    </feature>
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        <location>
            <begin position="1143"/>
            <end position="1192"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1398" mass="161110" checksum="1F15098F172E1182" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J193</accession>
    <name>A0A670J193_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-pass membrane protein with coiled-coil domains 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SMCO3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028746018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J193"/>
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        <property type="protein sequence ID" value="ENSPMRP00000018263.1"/>
        <property type="gene ID" value="ENSPMRG00000012022.1"/>
    </dbReference>
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    <dbReference type="CTD" id="440087"/>
    <dbReference type="GeneTree" id="ENSGT00390000013440"/>
    <dbReference type="OMA" id="MSTNFHA"/>
    <dbReference type="Proteomes" id="UP000472272">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027895">
        <property type="entry name" value="DUF4533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040004">
        <property type="entry name" value="SMCO3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35972">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35972:SF1">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15047">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="262" mass="29051" checksum="2BBC12F5A337963F" modified="2020-06-17" version="1">MQQQNYFPLPLSAHLCRMSLSDLLYPNNPQRRQDVIALHQELLDCMQLNFKATDELIGALNEHLGAKIAHVKMKEGGTIKENCDIIIRAMTDIQQEVWKFDKEIKEKLEPLMYRKLYDIKEPELEKIAIAHRIVSVILGEATASAGIVAVKLVCSNIVTVTVNKLVALLAQIGLSVLGGIAISALGLGIDIILHAILGAVERDHLVACIESYEQHLAEFKEASQIYHCAITEVSAMVKDKAKLGISGDVPTHWSLHTGHYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J420</accession>
    <name>A0A670J420_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114605474</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2B family.</text>
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    <dbReference type="RefSeq" id="XP_028602649.1">
        <property type="nucleotide sequence ID" value="XM_028746816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J420"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019447.1">
        <property type="protein sequence ID" value="ENSPMRP00000018284.1"/>
        <property type="gene ID" value="ENSPMRG00000012040.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114605474"/>
    <dbReference type="GeneTree" id="ENSGT01110000267181"/>
    <dbReference type="OMA" id="HYNKPST"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
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    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="13"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="126" mass="13977" checksum="5E0D6328CE34D6C1" modified="2020-06-17" version="1">MPEPAKSVPASKKGSKKAVTKTHKKGDKKRKKVRKESYSIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEATRLAHYNKRSTVTSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4A1</accession>
    <name>A0A670J4A1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CXXC-type zinc finger protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CXXC5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with DVL1. Interacts with RBPJ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028594102.1">
        <property type="nucleotide sequence ID" value="XM_028738269.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594103.1">
        <property type="nucleotide sequence ID" value="XM_028738270.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594104.1">
        <property type="nucleotide sequence ID" value="XM_028738271.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594105.1">
        <property type="nucleotide sequence ID" value="XM_028738272.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594106.1">
        <property type="nucleotide sequence ID" value="XM_028738273.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594107.1">
        <property type="nucleotide sequence ID" value="XM_028738274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J4A1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020276.1">
        <property type="protein sequence ID" value="ENSPMRP00000019096.1"/>
        <property type="gene ID" value="ENSPMRG00000012479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601170"/>
    <dbReference type="KEGG" id="pmua:114601170"/>
    <dbReference type="CTD" id="51523"/>
    <dbReference type="GeneTree" id="ENSGT00940000154108"/>
    <dbReference type="OMA" id="ANGHDPP"/>
    <dbReference type="OrthoDB" id="8777148at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043467">
        <property type="term" value="P:regulation of generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040388">
        <property type="entry name" value="CXXC4/CXXC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13419:SF2">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13419">
        <property type="entry name" value="ZINC FINGER-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="13">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="274" mass="29916" checksum="304173865882673F" modified="2020-06-17" version="1">MSETGSHQDASSKPGLLEKNKNPDDSQPSVNSERRNKSGIISEPLNKSLKKSRPLSHYSTFGSTSSLSEHSEKGAPVANGNEATMDKSNSTSKHKSISDMLSKSDISAEGQSILQQFAQSTELLKRVVQEHIPLPNDHGTGISDMEAVSAAETMNSPSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQNELASAINSGKKKRKRCGMCPPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4Z6</accession>
    <name>A0A670J4Z6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vestigial like family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VGLL4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May act as a specific coactivator for the mammalian TEFs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vestigial family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J4Z6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020444.1">
        <property type="protein sequence ID" value="ENSPMRP00000019255.1"/>
        <property type="gene ID" value="ENSPMRG00000012585.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003282"/>
    <dbReference type="OMA" id="CPIAHSS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001223">
        <property type="term" value="F:transcription coactivator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060044">
        <property type="term" value="P:negative regulation of cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006627">
        <property type="entry name" value="TDU_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028184">
        <property type="entry name" value="VGLL4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604:SF1">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15245">
        <property type="entry name" value="VGLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00711">
        <property type="entry name" value="TDU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="343" mass="38032" checksum="D73A12CB9425E698" modified="2020-06-17" version="1">MQIFHLNEFLLSACQRSPCFTIFCSNEMFFSLYFSRFRKLQNIFVLFRILPGMETPLDVLSRAASLVHADDEKREAALRGEPRMQSLPVSAAVTNHRTGPPPISPCKRRFSMDQGDDDLDCENEHVSKMSRMFSPHLMKAANGDYRKEHRDRSRSPIERAAAPTMSLHTNHIYASIPSLPMDQPLALTKNSMDATRSVSITPTMTSVERQQNRPSVITCASAINRNCNLSHCPIAHSGCGTAMPASYRRPSSTTTACDPVVEEHFRRSLGKNYKEPEPVTNSVSITGSVDDHFTKALGETWLQIKAAKDGVSSSPESASRRGQSSSPPSSHMVNHNHSPSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5C3</accession>
    <name>A0A670J5C3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 420-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114605416</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028602528.1">
        <property type="nucleotide sequence ID" value="XM_028746695.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028602530.1">
        <property type="nucleotide sequence ID" value="XM_028746697.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028602531.1">
        <property type="nucleotide sequence ID" value="XM_028746698.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028602532.1">
        <property type="nucleotide sequence ID" value="XM_028746699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J5C3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020954.1">
        <property type="protein sequence ID" value="ENSPMRP00000019723.1"/>
        <property type="gene ID" value="ENSPMRG00000012879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605416"/>
    <dbReference type="KEGG" id="pmua:114605416"/>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="KHLECGK"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001639">
        <property type="entry name" value="Si:dkey-7i4.21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000380">
        <property type="entry name" value="zinc finger protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="559" mass="64000" checksum="F41CC11B29DD4D63" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J825</accession>
    <name>A0A670J825_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mesotocin receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114605958</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028603517.1">
        <property type="nucleotide sequence ID" value="XM_028747684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J825"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021610.1">
        <property type="protein sequence ID" value="ENSPMRP00000020345.1"/>
        <property type="gene ID" value="ENSPMRG00000013260.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605958"/>
    <dbReference type="KEGG" id="pmua:114605958"/>
    <dbReference type="GeneTree" id="ENSGT01050000244882"/>
    <dbReference type="OMA" id="MQDSTHQ"/>
    <dbReference type="OrthoDB" id="5987909at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045907">
        <property type="term" value="P:positive regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001992">
        <property type="term" value="P:regulation of systemic arterial blood pressure by vasopressin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000205">
        <property type="entry name" value="[Arg8]-vasotocin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001817">
        <property type="entry name" value="Vasoprsn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF74">
        <property type="entry name" value="ARGININE VASOPRESSIN RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00896">
        <property type="entry name" value="VASOPRESSINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="58"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU046427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="370" mass="42017" checksum="B5568CF3FBC78DC3" modified="2020-06-17" version="1">MKNFSFSKDDYEPGVPFLPGFLNSTNAPALPERQSRNEQLALVEIAVLGIIFATASVGNIILILVLWRRRMKLSRMYVFLLHLSIADLMVAFFQVLPQLFWKITDVFMGPDILCRTIIYLQLLSMFASTYMIVVMALDRYQAVCRPMASFPKKAALWNPPICTSWFISLVFSVPQVFIFRKREVSPGIFDCQADFIEPWGTKVYVTWISIAIFFLPAAVLIVCHVRICRAIQMHMHLKSSNELEVTNQKQIQPCQGNNASCTLKAMIKTIKMTVVIVVAYIFCWSPFFIAQLWTAWHPSDARTEGPVIAILMLLGNLNSCVNPWIYMYFCGQIPRCSKKIQDNAADHEESTITGSVNLGEKESEDNITSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8T9</accession>
    <name>A0A670J8T9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flt3-interacting zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FIZ1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028607542.1">
        <property type="nucleotide sequence ID" value="XM_028751709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J8T9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021953.1">
        <property type="protein sequence ID" value="ENSPMRP00000020671.1"/>
        <property type="gene ID" value="ENSPMRG00000013431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607980"/>
    <dbReference type="KEGG" id="pmua:114607980"/>
    <dbReference type="CTD" id="84922"/>
    <dbReference type="GeneTree" id="ENSGT01150000286918"/>
    <dbReference type="OMA" id="SLYQCEC"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000621">
        <property type="entry name" value="FLT3-interacting zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000790">
        <property type="entry name" value="flt3-interacting zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001711">
        <property type="entry name" value="Flt3-interacting zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000286">
        <property type="entry name" value="Zinc finger protein 770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="480" mass="53727" checksum="A2192FF3ECB81511" modified="2020-06-17" version="1">MENCDEEWPEGQHSLQAPGGVRATTGTVEECAVLYSDAEDDPSLLTDHGPGARAPFHCSECDKSFRYRSDLRRHFARHTELKPFQCPHCVKSFKHSFNLVNHIRSHTGERPYRCTMCPKGFRDSTGLLHHQVVHTGEKPYCCHVCELRFSSRSSLGRHLKRQHRASPAAAAPQTPAPRCLACGKEQSPLGHLCSAGRGRAAPFGCGACGRHFQLASELRRHWLAHTDIKPFKCPDCERDFNAAALLERHKLTHAKDRPPPCPVCSGKVPPSDGMLELRGLEEESRDGGPEAQQHSRGCPTCHPPDMRPPETLYQCECGTFFANGNTLAAHLTAHGGEPSFSCGICGQPFVNLQTLEEHQLSHAVAASPMSGPGSELERHLLPQLDLRAFPARPSKKLYKCSECEKYFRSPRDLDRHVLVHTGEKPYQCTECGKFFRHECYLKRHRLLHSGERPFKCTVCHKGFITLSNLSRHLKLHRGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8X5</accession>
    <name>A0A670J8X5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J8X5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021994.1">
        <property type="protein sequence ID" value="ENSPMRP00000020711.1"/>
        <property type="gene ID" value="ENSPMRG00000013452.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286959"/>
    <dbReference type="OMA" id="ICEERIG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000320">
        <property type="entry name" value="Zinc finger protein 777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="248" mass="27067" checksum="0708A83FB8573B0A" modified="2020-06-17" version="1">MQAQFLIGGRSTGRAPLLRSPLCLVPCSLTCLHTPVAIGLIQHSTSSRSSFLPPGSDTPSEEEEEMVEGAEEQGASTCLESWDWGQAASGEKDAEASVTTDPRPFRCSECGKGFAQSSNLVKHQRIHTGERPFRCPECGRGFSWSSSLAEHLKAHGGRRPHACGECGKRFARGSTLAEHQRVHTGEKPFRCHQCGARFSQSSTLAHHLRTHSGERPHACPDCGKRFGRKSTLVTHRHAVKTIFCKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J9T9</accession>
    <name>A0A670J9T9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin-like protein KIF24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KIF24</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle. Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with CCP110, CEP97, TALPID3. Interacts with MPHOSPH9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028604315.1">
        <property type="nucleotide sequence ID" value="XM_028748482.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028604316.1">
        <property type="nucleotide sequence ID" value="XM_028748483.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028604318.1">
        <property type="nucleotide sequence ID" value="XM_028748485.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028604319.1">
        <property type="nucleotide sequence ID" value="XM_028748486.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028604320.1">
        <property type="nucleotide sequence ID" value="XM_028748487.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000022253.1">
        <property type="protein sequence ID" value="ENSPMRP00000020955.1"/>
        <property type="gene ID" value="ENSPMRG00000013623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606348"/>
    <dbReference type="KEGG" id="pmua:114606348"/>
    <dbReference type="CTD" id="347240"/>
    <dbReference type="GeneTree" id="ENSGT00940000154046"/>
    <dbReference type="OMA" id="WGNTFAK"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09541">
        <property type="entry name" value="SAM_KIF24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000052">
        <property type="entry name" value="Kinesin family member 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF20">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="218"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="636"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="800"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1024"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1267"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1295"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="308"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1391" mass="153631" checksum="A7147829591C97EE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JA04</accession>
    <name>A0A670JA04_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">26S proteasome regulatory subunit RPN7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PSMD6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD6, a base containing 6 ATPases and few additional components.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JA04"/>
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        <property type="protein sequence ID" value="ENSPMRP00000020489.1"/>
        <property type="gene ID" value="ENSPMRG00000013339.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000046608"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000004">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="193"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="402" mass="47124" checksum="A4CA1882F6819DC1" modified="2020-06-17" version="1">MPLENLEEEGLPKNPDLRIAQLRFLLSLQPKRPDPAVRQELMAAIREHDMAPYYESLCKSLDWQVDTDLLNKMKKANEEELKRLDEQLEDAEKNLGESEIRDAMMAKAEYLCRIGDKEAALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALDRPDLREKVIKGAEILEVLHSLPKVRQYLFSLYECRYSVFFQSLATVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMADAFGVCVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRYSMLDTTPTNTKKLVVTSCLTLRTLQPFNCCPTKRIAYVLQMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBJ4</accession>
    <name>A0A670JBJ4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Opticin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OPTC</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028590015.1">
        <property type="nucleotide sequence ID" value="XM_028734182.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028590016.1">
        <property type="nucleotide sequence ID" value="XM_028734183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JBJ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022976.1">
        <property type="protein sequence ID" value="ENSPMRP00000021651.1"/>
        <property type="gene ID" value="ENSPMRG00000014053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599278"/>
    <dbReference type="KEGG" id="pmua:114599278"/>
    <dbReference type="CTD" id="26254"/>
    <dbReference type="GeneTree" id="ENSGT00940000154248"/>
    <dbReference type="OMA" id="EEHKYTR"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061975">
        <property type="term" value="P:articular cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043547">
        <property type="entry name" value="Mimecan/Epiphycan/Opticin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46269">
        <property type="entry name" value="EPIPHYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46269:SF4">
        <property type="entry name" value="OPTICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025437243" evidence="11">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="12">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="332" mass="36910" checksum="FC6837F782E4CC5C" modified="2020-06-17" version="1">MQTAALVGIISALALALAVPLKEDGKKTEKHRPATYDSLDLGNYDLNLDNYGEVIDLSNYEENYDYGDLASKIEVGTLPPPTKSLLGPLSTTTGATEIPQKSPPTSTAARPQGPGLFGSITDQGLPTCLVCVCISTSVYCDDSDLEHIPPLPLETTYFYARFNHISKIQASDFTGLAKLKRIDLTSNFISWVDEDAFRMLPSLQELVLPENQLTSLPELPSSIVQLDARFNAIQSAGIQPEAFKDLKKLEFLHLSDNKLDYIPMLLPERLRSLHLQNNNIQTMHVDTFCDSRDHSHIRRALEDIRLDGNPINLSLFPSAYFCLPRLPTGRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFQ9</accession>
    <name>A0A670JFQ9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dysferlin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dystrophy-associated fer-1-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Fer-1-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DYSF</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferlin family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000024905.1">
        <property type="protein sequence ID" value="ENSPMRP00000023463.1"/>
        <property type="gene ID" value="ENSPMRG00000011495.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156187"/>
    <dbReference type="OMA" id="AYCSVTY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002281">
        <property type="term" value="P:macrophage activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002280">
        <property type="term" value="P:monocyte activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050765">
        <property type="term" value="P:negative regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08373">
        <property type="entry name" value="C2A_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000009">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000021">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000026">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000037">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000061">
        <property type="entry name" value="dysferlin isoform X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037726">
        <property type="entry name" value="C2A_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
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                <person name="Pinho C."/>
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJN5</accession>
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        <alternativeName>
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    <gene>
        <name evidence="11" type="primary">NOP56</name>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL or FBLL1 assemble stepwise onto the snoRNA. Interacts with NOP1 and NOP58. Interacts with NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP56 with NUFIP1. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with NOP2 and FBL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028600399.1">
        <property type="nucleotide sequence ID" value="XM_028744566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JJN5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026636.1">
        <property type="protein sequence ID" value="ENSPMRP00000025103.1"/>
        <property type="gene ID" value="ENSPMRG00000016227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604462"/>
    <dbReference type="KEGG" id="pmua:114604462"/>
    <dbReference type="CTD" id="10528"/>
    <dbReference type="GeneTree" id="ENSGT00940000153534"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990226">
        <property type="term" value="F:histone methyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="292"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="537" mass="60132" checksum="8EF781F748197832" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJR0</accession>
    <name>A0A670JJR0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JJR0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025666.1">
        <property type="protein sequence ID" value="ENSPMRP00000024200.1"/>
        <property type="gene ID" value="ENSPMRG00000015643.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286948"/>
    <dbReference type="OMA" id="IFTMMAN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15911">
        <property type="entry name" value="7tmA_OR11A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000010">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050516">
        <property type="entry name" value="Olfactory_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26452">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="41"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="296" mass="33672" checksum="C1D4DFC7C14BDEC0" modified="2020-06-17" version="1">SSIVSSANKPIMFILLNFNNEDLWVLFSILFLPLYFVTIAGNILIVILVILDQRLHTPMYFFLGNLSCLETCYSSTIMPRMLVSFLTGDRTISIKGCFTQLYFFGSFAAAECYLLAVMSYDRYLAICRPLHYVTLMDGRICIMLIAGSWISGFLGMNIVLYFVSQLRFCGPNKINHFFCDLTPMVRLSCILPSFLITLTSYAFIINSILRIASTTGKQKAFSTCSSHLTVVACFYGSLMIVYVLPNMNSLSDLKKVFSLFYTLLTPLVNPLVYSLRNKEVKEAIKKTLFKMFNRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKX1</accession>
    <name>A0A670JKX1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ral transcription factor IIIC subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GTF3C1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028561315.1">
        <property type="nucleotide sequence ID" value="XM_028705482.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000025059.1">
        <property type="protein sequence ID" value="ENSPMRP00000023612.1"/>
        <property type="gene ID" value="ENSPMRG00000015287.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000025076.1">
        <property type="protein sequence ID" value="ENSPMRP00000023629.1"/>
        <property type="gene ID" value="ENSPMRG00000015287.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000025107.1">
        <property type="protein sequence ID" value="ENSPMRP00000023658.1"/>
        <property type="gene ID" value="ENSPMRG00000015287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584034"/>
    <dbReference type="CTD" id="2975"/>
    <dbReference type="GeneTree" id="ENSGT00390000008664"/>
    <dbReference type="OMA" id="TIIQDGI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056428">
        <property type="entry name" value="WH_GTF3C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23704">
        <property type="entry name" value="WHD_GTF3C1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="General transcription factor 3C polypeptide 1 winged-helix" evidence="8">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="174"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="9">
        <location>
            <begin position="618"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="838"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1189"/>
            <end position="1249"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
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        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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            <dbReference type="Pfam" id="PF24101"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023612.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JN18</accession>
    <name>A0A670JN18_PODMU</name>
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        <recommendedName>
            <fullName evidence="20">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
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    </protein>
    <gene>
        <name evidence="22" type="primary">HMGCR</name>
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    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <reaction evidence="19">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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        </reaction>
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            <dbReference type="Rhea" id="RHEA:15991"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Endoplasmic reticulum membrane</location>
            <topology evidence="1 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the HMG-CoA reductase family.</text>
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        <property type="nucleotide sequence ID" value="XM_028748335.1"/>
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    <dbReference type="RefSeq" id="XP_028604169.1">
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    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000028053.1">
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    <dbReference type="KEGG" id="pmua:114606284"/>
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    <dbReference type="GeneTree" id="ENSGT00940000155305"/>
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    <dbReference type="OrthoDB" id="310654at2759"/>
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        <property type="reaction ID" value="UER00103"/>
    </dbReference>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005778">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120225">
        <property type="term" value="F:coenzyme A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:long-term synaptic potentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900222">
        <property type="term" value="P:negative regulation of amyloid-beta clearance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008542">
        <property type="term" value="P:visual learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000002">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
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        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
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        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
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        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
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    <dbReference type="InterPro" id="IPR004816">
        <property type="entry name" value="HMG_CoA_Rdtase_metazoan"/>
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    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
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    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
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    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00920">
        <property type="entry name" value="2A060605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8 20" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="21">
        <location>
            <begin position="61"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="882" mass="96661" checksum="FEE1AE9A121AEB5E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQ78</accession>
    <name>A0A670JQ78_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Roundabout guidance receptor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ROBO3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the immunoglobulin superfamily. ROBO family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000028171.1">
        <property type="protein sequence ID" value="ENSPMRP00000026556.1"/>
        <property type="gene ID" value="ENSPMRG00000017166.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155457"/>
    <dbReference type="OMA" id="NCCTTNH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022603">
        <property type="term" value="P:regulation of anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07693">
        <property type="entry name" value="IgC_1_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000053">
        <property type="entry name" value="Roundabout guidance receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000055">
        <property type="entry name" value="roundabout homolog 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000065">
        <property type="entry name" value="roundabout homolog 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000026">
        <property type="entry name" value="roundabout homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000008">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000043">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000058">
        <property type="entry name" value="roundabout homolog 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
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        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
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    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF236">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025647718" evidence="19">
        <location>
            <begin position="21"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="898"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="68"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="170"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="262"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="351"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="454"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="562"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="676"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="773"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1071"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1137"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1184"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1201"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1302"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1322"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1400"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1427"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1436" mass="156356" checksum="41BCF3362A3C0B70" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQ92</accession>
    <name>A0A670JQ92_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch like family member 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KLHL18</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028750108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JQ92"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026688.1">
        <property type="protein sequence ID" value="ENSPMRP00000025146.1"/>
        <property type="gene ID" value="ENSPMRG00000016270.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000026695.1">
        <property type="protein sequence ID" value="ENSPMRP00000025152.1"/>
        <property type="gene ID" value="ENSPMRG00000016270.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607171"/>
    <dbReference type="CTD" id="23276"/>
    <dbReference type="GeneTree" id="ENSGT00940000157026"/>
    <dbReference type="OMA" id="DRWTIVT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18457">
        <property type="entry name" value="BACK_KLHL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18247">
        <property type="entry name" value="BTB_POZ_KLHL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030603">
        <property type="entry name" value="KLHL18_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF497">
        <property type="entry name" value="KELCH-LIKE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
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    </dbReference>
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        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
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    </dbReference>
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        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
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        <property type="entry name" value="BACK"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kelch motif"/>
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    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="578" mass="64261" checksum="46B064A8B6B3829B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRN8</accession>
    <name>A0A670JRN8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RIMS-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RIMBP2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIMBP family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000028733.1">
        <property type="protein sequence ID" value="ENSPMRP00000027086.1"/>
        <property type="gene ID" value="ENSPMRG00000017477.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183203"/>
    <dbReference type="OMA" id="TAKCSPG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd12014">
        <property type="entry name" value="SH3_RIM-BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12012">
        <property type="entry name" value="SH3_RIM-BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12013">
        <property type="entry name" value="SH3_RIM-BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000023">
        <property type="entry name" value="RIMS-binding protein 2 isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000006">
        <property type="entry name" value="RIMS-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000072">
        <property type="entry name" value="RIMS-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000643">
        <property type="entry name" value="RIMS-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000016">
        <property type="entry name" value="RIMS-binding protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057884">
        <property type="entry name" value="FN3_RIM-BP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035753">
        <property type="entry name" value="RIM-BP_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035755">
        <property type="entry name" value="RIM-BP_SH3_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
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        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
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        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE R"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025648099" description="protein-tyrosine-phosphatase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="653"/>
        </location>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="389"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="558"/>
            <end position="634"/>
        </location>
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        <location>
            <position position="584"/>
        </location>
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        <location>
            <position position="550"/>
        </location>
        <ligand>
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        <location>
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        <ligand>
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        <location>
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        <source>
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    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="653" mass="73083" checksum="1E2CA3DE68F26A61" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZK4</accession>
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            <fullName evidence="1">ENTH domain-containing protein</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Episquamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="83" mass="9440" checksum="2FB9FE493B163230" modified="2020-06-17" version="1">MDSATAKAICKAMTHNKVMGPRKKHLNHLIQCTTEMDVNIPQLAETIFERTANKSWVVLFKPLIATPHLTMYGNEHFIKYLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K060</accession>
    <name>A0A670K060_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Potassium calcium-activated channel subfamily N member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KCNN1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Bosakova Z."/>
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                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="2">Sarcomere</location>
            <location evidence="2">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K060"/>
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        <property type="protein sequence ID" value="ENSPMRP00000030221.1"/>
        <property type="gene ID" value="ENSPMRG00000019538.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Small conductance calcium-activated potassium channel, isoform O"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Small conductance calcium-activated potassium channel, isoform O"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CaM-bd_dom"/>
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    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01451">
        <property type="entry name" value="SKCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin-binding" evidence="13">
        <location>
            <begin position="373"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="500"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="447"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="535" mass="60784" checksum="3D2741069AA1AC75" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0K6</accession>
    <name>A0A670K0K6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K0K6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031474.1">
        <property type="protein sequence ID" value="ENSPMRP00000029675.1"/>
        <property type="gene ID" value="ENSPMRG00000019194.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="SCNINAC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001621">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger 202 m1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
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    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF152">
        <property type="entry name" value="SI:DKEY-210J14.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="189"/>
        </location>
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        <location>
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            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="389" mass="44911" checksum="057F1D981B775CFE" modified="2020-06-17" version="1">MVEVREMVASQGDVWGVLDEEEPPEVWPERGEEQEKERKLGVQDGANKQEGRETVKPRDEHSVSQEDENQINRVEKKHECTVCGKRFCSRSALARHQSVHSGEKPYKCLECGNNFSRSSSLNVHQRTHTGEKPYTCMECGKSFNQSSSLNVHRRSHTSEKPYKCMECGKRFRNSGHLNVHRRSHTGEKPNTCMECGKSFTHSASLNVHRRSHTGEKPYKCMECGKRFRNSGHLTLHQRTHTGEKPYECMECGKRFRNSDYLTLHQRTHTGEKPYKCWECGKSFFDSSTLIKHQRTHTGEKPYTCMECGKSFNQSASLNVHRRSHTGEKPYKCMECGKSFSCSKSVKMHHIIHTQENHINPYKCMECGKSFSTRSILIRHQKTHTGEKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2E5</accession>
    <name>A0A670K2E5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K2E5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031653.1">
        <property type="protein sequence ID" value="ENSPMRP00000029844.1"/>
        <property type="gene ID" value="ENSPMRG00000019306.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="INFRSSC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000806">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001901">
        <property type="entry name" value="Zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="313"/>
            <end position="340"/>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="341"/>
            <end position="368"/>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="369"/>
            <end position="396"/>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="397"/>
            <end position="424"/>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="425"/>
            <end position="452"/>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="453"/>
            <end position="480"/>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="218"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="707" mass="78667" checksum="1CDBF7117D3D73E3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K326</accession>
    <name>A0A670K326_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lysophosphatidic acid receptor 4</fullName>
        </submittedName>
    </protein>
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        <name evidence="13" type="primary">LPAR4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="lysophosphatidic acid receptor 4"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF41">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID RECEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="P2Y5ORPHANR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
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            <begin position="35"/>
            <end position="290"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="348" mass="39605" checksum="B62CF51AE3305178" modified="2020-06-17" version="1">MGNHSNNHTCMTDDSFKYNLYGAVYSMVFILGLITNCASLFVFCCRINMRSETTIFMTNLVVSDLLFVFTLPFKIFYNFNRHWPFGDLLCRISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRKNTAIVCMGVWILVLSGGISASLFSTTNTYNTSTTCFEGFSKSIWKTYLSKITIFIEVVGFLIPLLLNLICSSLVLRTLRKPATLSQIGTNKEKVLKMIVVHLAIFLVCFVPYNSILFLYALVRSQAIANCFLERFARTFYPITLCIATLNCCFDPFIYYFTSESFQKSFYITPHLKTDSLFKTETPLTKIALPVMQDEMSDQAITKGGELTSESNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4B7</accession>
    <name>A0A670K4B7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">COQ9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Heterodimer; two heterodimers of COQ7:COQ9 come together on the same side of the lipid pseudo-bilayer and form a curved tetramer with a hydrophobic surface suitable for membrane interaction. These two tetramers assemble into a soluble octamer with a pseudo-bilayer of lipids captured within. Interacts with COQ7; this interaction allows ubiquinone (CoQ) isoprene intermediates presentation to COQ7 and facilitates the COQ7-mediated hydroxylase step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028595145.1">
        <property type="nucleotide sequence ID" value="XM_028739312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K4B7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032346.1">
        <property type="protein sequence ID" value="ENSPMRP00000030499.1"/>
        <property type="gene ID" value="ENSPMRG00000019744.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601794"/>
    <dbReference type="KEGG" id="pmua:114601794"/>
    <dbReference type="CTD" id="57017"/>
    <dbReference type="GeneTree" id="ENSGT00390000009328"/>
    <dbReference type="OMA" id="CAGFGWN"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:ubiquinone biosynthesis complex"/>
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        <property type="term" value="F:enzyme activator activity"/>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
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        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
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    <dbReference type="InterPro" id="IPR048674">
        <property type="entry name" value="COQ9_HTH"/>
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    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
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        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
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        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
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        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21392">
        <property type="entry name" value="COQ9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Ubiquinone biosynthesis protein COQ9 HTH" evidence="12">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="COQ9 C-terminal" evidence="11">
        <location>
            <begin position="210"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="95"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="74"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="94"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
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            <dbReference type="ARBA" id="ARBA00010766"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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            <dbReference type="ARBA" id="ARBA00062895"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF08511"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21392"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030499.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="315" mass="35124" checksum="15A17445DAE7FB8C" modified="2020-06-17" version="1">MAAAAASLRRAGWGLLRCQAVFRRQLYPVQRAIQSAAVLRRASDEQKQQPPQSSTQQHLESELVGEQHDQEHPHLHPSYTDQGGEESEGYESEEQLQHQILTAALEFVPTHGWTADAIAEGAKSLGLSVAAAGLFHNDGSELILHFVAQCNSKLTELLEEQHKLVQLGQAEKKKTDQFLKDALEARLRMLIPYIEKWPQAISVLLLPHNIPASLNLLTSMVDDMWHYAGDQSTDINWYTRRAVLAGIYNTTELVMIQDSSPDFEETWSFLQNRIADAMNMGHTAKQVQATGEALVQGLMGAAVTIRNLTGLNQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K712</accession>
    <name>A0A670K712_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium/myo-inositol cotransporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Sodium/myo-inositol transporter 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 5 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC5A3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="15">Interacts with KCNQ2 (via the pore module). Interacts with KCNQ1; this interaction is direct. Forms coregulatory complexes with ion channels KCNQ2-KCNQ3 and KCNQ1-KCNE2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028582938.1">
        <property type="nucleotide sequence ID" value="XM_028727105.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028582939.1">
        <property type="nucleotide sequence ID" value="XM_028727106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K712"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034027.1">
        <property type="protein sequence ID" value="ENSPMRP00000032085.1"/>
        <property type="gene ID" value="ENSPMRG00000020806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596063"/>
    <dbReference type="KEGG" id="pmua:114596063"/>
    <dbReference type="CTD" id="6526"/>
    <dbReference type="GeneTree" id="ENSGT00940000161679"/>
    <dbReference type="OMA" id="VGIFMFV"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007422">
        <property type="term" value="P:peripheral nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903428">
        <property type="term" value="P:positive regulation of reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043576">
        <property type="term" value="P:regulation of respiratory gaseous exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000013">
        <property type="entry name" value="sodium/myo-inositol cotransporter isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF150">
        <property type="entry name" value="SODIUM_MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0915">Sodium</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="714" mass="79169" checksum="273A91430A6BBF21" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7C3</accession>
    <name>A0A670K7C3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7C3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033464.1">
        <property type="protein sequence ID" value="ENSPMRP00000031549.1"/>
        <property type="gene ID" value="ENSPMRG00000020437.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182788"/>
    <dbReference type="OMA" id="RAWDLKI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000024">
        <property type="entry name" value="Vomeronasal 2, receptor 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="476"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="758" mass="85239" checksum="BA66E205350CDC38" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7G5</accession>
    <name>A0A670K7G5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GOLM2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Golgi membrane protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GOLM2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7G5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034697.1">
        <property type="protein sequence ID" value="ENSPMRP00000032721.1"/>
        <property type="gene ID" value="ENSPMRG00000021201.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063675"/>
    <dbReference type="OMA" id="XRFFDEN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026139">
        <property type="entry name" value="GOLM1/CASC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15896">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 2/GP73-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15896:SF7">
        <property type="entry name" value="PROTEIN GOLM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02084">
        <property type="entry name" value="GOLM1CASC4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="431" mass="49165" checksum="A10252C7F51D5DAA" modified="2020-06-17" version="1">MVGFGANRRGGRLPSFLFVALLLVIAVLAFNYWTTSSRQTVLQEEVAELQGQAKRSDVARGRLEKRNSELLLQGELHKKQLEQKEAEHSQLSNQLQAREGQIRKCEESRIKLQNNISYQMADIHRLKEQLAELRQEFIRQEDQLHEYRNNNTQLLKRLEYESFQCGHQIKELRMQHEENMRKLEDQVTQDQKAAHRSQSSKDIESNLSNNPTILKTTQQLDEKNVIRNETPSINNISDGKEKIKPGDDAGMPGIEENDAAKAEDTLTALKKPLVSASQNEPQPNGNLPTEKPHAPNLAQGVNSNQDGNADIIKQIPPNPLQHLIPDHVLDNQKAEKEHLKKDRISDFQRMKQSRFFDENESPVDPQHGSKLADYNGDDGNVGEYEADKQAELAYNEEEDGDGGEEDVQDDEERELQMELADYGKPHFNDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8U4</accession>
    <name>A0A670K8U4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L1 transposable element RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K8U4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036044.1">
        <property type="protein sequence ID" value="ENSPMRP00000033983.1"/>
        <property type="gene ID" value="ENSPMRG00000022047.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000210027"/>
    <dbReference type="OMA" id="WILGTIE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.250.20">
        <property type="entry name" value="L1 transposable element, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042566">
        <property type="entry name" value="L1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="42309" checksum="E14FEAB34B631110" modified="2020-06-17" version="1">NFPNSLRILSRRLWPLLSPDQLEEYSFSFSPPSVLFSSWILGTIEVLPFILPLLKARRVFQSSIPPLEHQQRGKISRQEEIRDLDALWLKIKEEFRQNETHMEKKLGEMQESFDKKIEQAVGEMSNKIKDLTVRTKSLEDSNRKMQREMKDQRREAGKIKENFEELNKSQDQQLNLKFRGIGEVRDEDIKGKMTIELARWLALREDEVAQTIENAFRIKIRPKQNKQKKTPGDCLVIFRSIEMRNRILKESYQKKLIIDGRPIIIFKEIPIRLLRKREGYKQIVNTLRKNGIQHRWEFPEGISFFYKEKRFKITEIQEVSKFLHDTIGRFQCSADIRNGQTNRKEKKKTGKVAGIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9B6</accession>
    <name>A0A670K9B6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3 and PZP like alpha-2-macroglobulin domain containing 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CPAMD8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000034942.1">
        <property type="protein sequence ID" value="ENSPMRP00000032935.1"/>
        <property type="gene ID" value="ENSPMRG00000021337.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162399"/>
    <dbReference type="OMA" id="CGCARDC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.20.50.160:FF:000002">
        <property type="entry name" value="Thioester-containing protein 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF139">
        <property type="entry name" value="C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="8">
        <location>
            <begin position="1528"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1336"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1347"/>
            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1629" mass="179064" checksum="092473932BBF5249" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBG4</accession>
    <name>A0A670KBG4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Taste receptor type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114588000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor T2R family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KBG4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034088.1">
        <property type="protein sequence ID" value="ENSPMRP00000032147.1"/>
        <property type="gene ID" value="ENSPMRG00000020848.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286961"/>
    <dbReference type="OMA" id="TNIFVEI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033038">
        <property type="term" value="F:bitter taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13950">
        <property type="entry name" value="7tm_TAS2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000055">
        <property type="entry name" value="Taste receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007960">
        <property type="entry name" value="TAS2R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394:SF47">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2 MEMBER 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05296">
        <property type="entry name" value="TAS2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="3 12" id="KW-0919">Taste</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="307" mass="35000" checksum="AA27AAB6FC4271B8" modified="2020-06-17" version="1">MLRKMPTLFKLFGFVLLVIETLIGMVGNGFIAIVNCIDWFRSRKLSPADMILSCLSLFRFAFHVVLIRAEIFNLFLVNPVLMLNLNISSDFSWLFLNTASLWFAAWLSVLYCVKIANFSHPLFLQMKRRFPGLVPWLLLGTVVFSAITTTVALTGSNIFSKCNLYESHLNKNNDSAINTSNSCEFLILLYIFPNLFPFTMFLFSSILLLTSLWRHKNLLQNSARDVSTEVHLNAIKALASFFVLYVTNIFVEILSIVFFWKGINDNGVHLILFNVIAAYSSGHAVSLIFMSPKLKQESIKMLHQLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCB6</accession>
    <name>A0A670KCB6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small ribosomal subunit protein uS17m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">28S ribosomal protein S17, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPS17</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028563512.1">
        <property type="nucleotide sequence ID" value="XM_028707679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KCB6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037225.1">
        <property type="protein sequence ID" value="ENSPMRP00000035108.1"/>
        <property type="gene ID" value="ENSPMRG00000022727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585233"/>
    <dbReference type="KEGG" id="pmua:114585233"/>
    <dbReference type="CTD" id="51373"/>
    <dbReference type="GeneTree" id="ENSGT00530000064130"/>
    <dbReference type="OMA" id="TVHAKWI"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000137">
        <property type="entry name" value="28S ribosomal protein S17, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039193">
        <property type="entry name" value="Ribosomal_uS17m_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24088">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24088:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="137" mass="15509" checksum="DF1EB4C0DCB0293A" modified="2020-06-17" version="1">MSALRGAVHAKWIIGKVIGTKMRKTAKVRVTRLVLDPYLLKFYNKRKTYFAHDPQQQCIEGDIVLLKALPERRSKHVKHELAEIVYKVGKIIDPVTGKPCAGSRLLESVTDSENLTDRDTSYLSEKLQELTVSSSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCY1</accession>
    <name>A0A670KCY1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Neurturin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NRTN</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Growth factor that supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Involved in the development of the neural crest. Might control the size of non-neuronal cell population such as haemopoietic cells. Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor. Heparan sulfate-binding is required for signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer; disulfide-linked. Interacts with GFRA2 coreceptor and RET: forms a 2:2:2 ternary complex composed of NRTN ligand, GFRA2 and RET receptor. Also forms a 4:4:4 tetrameric complex composed of 4 copies of NRTN ligand, GFRA2 and RET receptor, which prevents endocytosis of RET.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TGF-beta family. GDNF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028569761.1">
        <property type="nucleotide sequence ID" value="XM_028713928.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028569762.1">
        <property type="nucleotide sequence ID" value="XM_028713929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KCY1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036315.1">
        <property type="protein sequence ID" value="ENSPMRP00000034225.1"/>
        <property type="gene ID" value="ENSPMRG00000022225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588545"/>
    <dbReference type="KEGG" id="pmua:114588545"/>
    <dbReference type="CTD" id="4902"/>
    <dbReference type="GeneTree" id="ENSGT00950000182993"/>
    <dbReference type="OMA" id="NQARRTK"/>
    <dbReference type="OrthoDB" id="9936891at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030116">
        <property type="term" value="F:glial cell-derived neurotrophic factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904399">
        <property type="term" value="F:heparan sulfate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035860">
        <property type="term" value="P:glial cell-derived neurotrophic factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19383">
        <property type="entry name" value="TGF_beta_Neurturin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000037">
        <property type="entry name" value="neurturin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043401">
        <property type="entry name" value="GDNF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173">
        <property type="entry name" value="GDNF SUBFAMILY OF TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173:SF3">
        <property type="entry name" value="NEURTURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="11">
        <location>
            <begin position="114"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="219" mass="24660" checksum="E602BE014BCCFCDE" modified="2020-06-17" version="1">MKVWKLAAIASMLFSSMLSVLVCRDLFTRSQEHTLFSSSLFSRTSSSSSLAGGHRRHPRALGRRGSLISQYSTLFESYTEGEIRHLISTLIERYSQSMNSGGHELPLFAKAGNRMKRAKARHKPCSLKELEVTVSELGLGYKSDETVLFRYCSGTCDSAVRNYDLSLKNVRSMRKIKKEKVRARPCCRPLSYDDDVSFLDAGNRYYTVNEVSAKECGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KE14</accession>
    <name>A0A670KE14_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium/potassium/calcium exchanger 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Na(+)/K(+)/Ca(2+)-exchange protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Solute carrier family 24 member 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KE14"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037772.1">
        <property type="protein sequence ID" value="ENSPMRP00000035633.1"/>
        <property type="gene ID" value="ENSPMRG00000023039.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234532"/>
    <dbReference type="OMA" id="RLWAWIT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000015">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF61">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="19" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-0769">Symport</keyword>
    <keyword evidence="9 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="26">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="26">
        <location>
            <begin position="247"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="413" mass="45105" checksum="F65A6DE124B4D96B" modified="2020-06-17" version="1">VLNYAQPPFIDIFLVSLLSDVAGATFMAAGSSAPELVTAFLGVFVTKGDIGVSTILGSAIYNLLGICAACGLLSGMVSRLSCWPLFRDCLAYAVSAAAVLAMIIDNKVYWYESASLLLIYGVYILVLCFDIKINQYIMKKFSRCCTCFTVTAEETEQQPLMGWKEESGPLLRRQSRADSGIFHDESDYAQLSSSLHGPDTISEDSQSVFTMPEADLKRVLWVLSLPVIALLYLTTPDCRRQFWKNWFMLTFFMSAVWISAFTYVLVWMVTIVGETLHIPDTVMGLTLLAAGTSIPDTVASVLVARKGRGDMAMSNIVGSNVFDLLCLGLPWFIRTAFVDTTAPAEVNSSGLTYTAISLVCSIAFIFLAVHLNGWKLDKKLGAVCLVMYLAFVILSILYELGAIGNNPISICGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEB7</accession>
    <name>A0A670KEB7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ARPC5L</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KEB7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035181.1">
        <property type="protein sequence ID" value="ENSPMRP00000033162.1"/>
        <property type="gene ID" value="ENSPMRG00000021505.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158501"/>
    <dbReference type="OMA" id="RQGNMNG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000006">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="127" mass="13870" checksum="56654453F7FAA4A6" modified="2020-06-17" version="1">GFPVNYNVKFLLISLEEIDLGTGGGDMLRAFHAALQNSPVNTKNHAAKERAQEVVLKVLTSFRGSEIEQAVNSLDSNGIDLLMKYIYKGFEKPTENSSAILLQWHEKALAVGGLGSIVRVLTARKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEU6</accession>
    <name>A0A670KEU6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KEU6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038076.1">
        <property type="protein sequence ID" value="ENSPMRP00000035928.1"/>
        <property type="gene ID" value="ENSPMRG00000023206.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003860"/>
    <dbReference type="OMA" id="CVPHKLF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="10">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="81" mass="9400" checksum="4F32584D68B2A2F4" modified="2020-06-17" version="1">MGWQDGKELEGQSGDPQEEGELLDPLTPVREHCEQIEKCLKAQERLEECNSQTEEKCTEELFDFLHARDHCVAHELFSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGA1</accession>
    <name>A0A670KGA1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 11 open reading frame 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C11orf52</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KGA1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038147.1">
        <property type="protein sequence ID" value="ENSPMRP00000035996.1"/>
        <property type="gene ID" value="ENSPMRG00000023257.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015195"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028106">
        <property type="entry name" value="DUF4578"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37342:SF1">
        <property type="entry name" value="CHROMOSOME 11 OPEN READING FRAME 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37342">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC689959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15147">
        <property type="entry name" value="DUF4578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="133" mass="14871" checksum="570F55DD447CA53A" modified="2020-06-17" version="1">MRAPCAPVRFSSPERQDFSLQRAKWATSAAAASGTRIIKSSTQQHPESKKGMDVGPVYDDVSEFPVYATVSKPKSMKRDDSSVHYADIQVFSKIRERSAEEVKTFQSQNTTEYATLNFPRATLKYDSKNGTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KHF5</accession>
    <name>A0A670KHF5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8810" checksum="92E36090DC7D9B82" modified="2020-06-17" version="1">LIVPFLVQQLEALKYGELRRLAKSAGLKANLKSDKLLHLLKQHFLAPVKENGSMGWERLIRTELIGSYLILNQTIGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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            <taxon>Lepidosauria</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
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                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <location evidence="2">Synaptic vesicle</location>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <text evidence="3">Belongs to the CSN4 family.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="406" mass="46243" checksum="E5699BFA29CFB76A" modified="2020-06-17" version="1">MAAAVRQELTQLMSSSGSHKDLAGKYRQILEKAIQLSGVEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPSLPDGTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKSIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJI8</accession>
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        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <scope>IDENTIFICATION</scope>
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        <source>
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        </source>
    </evidence>
    <sequence length="559" mass="63913" checksum="FD83179889DED8AF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KL67</accession>
    <name>A0A670KL67_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 211</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Chromosome 15"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF23">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16897" checksum="B9838F6044D4F73F" modified="2020-06-17" version="1">MHTSQKGCNLRPPLRYIPPTSQKFKCCFSPVTVYLLYEHYHISKTIKFLSQCVCVYYYIYILMPSSPFLPSLLLVFIMGFGLLVYPFGLGSTAVQRHCENSSIYYAGDCQIGWGYMLAIVGVMLSVFLPFFAKYAPKEHASPTPIPTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KMR1</accession>
    <name>A0A670KMR1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KMR1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038319.1">
        <property type="protein sequence ID" value="ENSPMRP00000036157.1"/>
        <property type="gene ID" value="ENSPMRG00000023368.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000208969"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF142">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF57.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="92" mass="10795" checksum="C45307ECE9AD531D" modified="2020-06-17" version="1">EKHPFSFEDVAVLFTAEEWALLDPAQRALHKEVMEETWRTMISLGKVPCWVIISVLEFSRYFSGTNLPYLDGSQRCHLECQGFSFFKKMNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KN19</accession>
    <name>A0A670KN19_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aquaporin 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">AQP9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>urea(in) = urea(out)</text>
            <dbReference type="Rhea" id="RHEA:32799"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028562350.1">
        <property type="nucleotide sequence ID" value="XM_028706517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KN19"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038489.1">
        <property type="protein sequence ID" value="ENSPMRP00000036322.1"/>
        <property type="gene ID" value="ENSPMRG00000023453.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000038494.1">
        <property type="protein sequence ID" value="ENSPMRP00000036327.1"/>
        <property type="gene ID" value="ENSPMRG00000023453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584554"/>
    <dbReference type="KEGG" id="pmua:114584554"/>
    <dbReference type="CTD" id="366"/>
    <dbReference type="GeneTree" id="ENSGT00940000160582"/>
    <dbReference type="OMA" id="WGFAVLT"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140070">
        <property type="term" value="F:hydrogen peroxide channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015265">
        <property type="term" value="F:urea channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071722">
        <property type="term" value="P:detoxification of arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000005">
        <property type="entry name" value="Aquaporin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015685">
        <property type="entry name" value="Aquaporin_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF6">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02021">
        <property type="entry name" value="AQUAPORIN9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="297" mass="32210" checksum="E992FB964CAC7D65" modified="2020-06-17" version="1">MSKIMKRSFKEKLALKNHLVKEALSEFLGTFILVALGCGAVAQSVLSRGELGGAPMISLGFAMAVTIAIYIAGGVSGGHINPAVTFAMCLSGKIRWIKFPVYVVAQFLGAFVGAAAVYWINYDLLMFYTEGKLTVTGVNKTAHIFATYPEEYLSVANGFSDQVMSTAILLLGVFAVFDPCNLPVPKGLEPIAIGLVIILLTSSMARNSGCAMNPARDLSPRLFTYFAGWGPEVFTAGHHFWWVPIVGPMVGAAIGTAIYMLFIELHHAPQEPPQRSTEHEKYTLTNMEEEKSLHTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HM77</accession>
    <name>A0A670HM77_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HIG1 hypoxia inducible domain family member 1C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HIGD1C</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028577331.1">
        <property type="nucleotide sequence ID" value="XM_028721498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HM77"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000799.1">
        <property type="protein sequence ID" value="ENSPMRP00000000753.1"/>
        <property type="gene ID" value="ENSPMRG00000000554.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593024"/>
    <dbReference type="KEGG" id="pmua:114593024"/>
    <dbReference type="CTD" id="613227"/>
    <dbReference type="GeneTree" id="ENSGT00940000162804"/>
    <dbReference type="OMA" id="SRGNTQM"/>
    <dbReference type="OrthoDB" id="10003563at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF10">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="97" mass="10540" checksum="4317D4591ABF479E" modified="2020-06-17" version="1">MSPDESWSPAEDDSQASKLARKSRDAPFVPIGLAGCFAVVGYGLYKLKHRGSQKMSVHLIHMRVAAQSFVVGAITVGVLYSMYTDYMKRSGTSGPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMQ0</accession>
    <name>A0A670HMQ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GJA5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 12">Cell membrane</location>
            <topology evidence="3 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the connexin family. Alpha-type (group II) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028582722.1">
        <property type="nucleotide sequence ID" value="XM_028726889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028582723.1">
        <property type="nucleotide sequence ID" value="XM_028726890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HMQ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000822.1">
        <property type="protein sequence ID" value="ENSPMRP00000000776.1"/>
        <property type="gene ID" value="ENSPMRG00000000568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595969"/>
    <dbReference type="KEGG" id="pmua:114595969"/>
    <dbReference type="CTD" id="2702"/>
    <dbReference type="GeneTree" id="ENSGT01150000286930"/>
    <dbReference type="OMA" id="FIHIHYG"/>
    <dbReference type="OrthoDB" id="9946832at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014704">
        <property type="term" value="C:intercalated disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086076">
        <property type="term" value="F:gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086077">
        <property type="term" value="F:gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086078">
        <property type="term" value="F:gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055077">
        <property type="term" value="F:gap junction hemi-channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048844">
        <property type="term" value="P:artery morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060413">
        <property type="term" value="P:atrial septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003294">
        <property type="term" value="P:atrial ventricular junction remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003161">
        <property type="term" value="P:cardiac conduction system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035050">
        <property type="term" value="P:embryonic heart tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035922">
        <property type="term" value="P:foramen ovale closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016264">
        <property type="term" value="P:gap junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003174">
        <property type="term" value="P:mitral valve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003151">
        <property type="term" value="P:outflow tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003193">
        <property type="term" value="P:pulmonary valve formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098910">
        <property type="term" value="P:regulation of atrial cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060371">
        <property type="term" value="P:regulation of atrial cardiac muscle cell membrane depolarization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098904">
        <property type="term" value="P:regulation of AV node cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098905">
        <property type="term" value="P:regulation of bundle of His cell action potential"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900825">
        <property type="term" value="P:regulation of membrane depolarization during cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098906">
        <property type="term" value="P:regulation of Purkinje myocyte action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900133">
        <property type="term" value="P:regulation of renin secretion into blood stream"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060373">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003071">
        <property type="term" value="P:renal system process involved in regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086015">
        <property type="term" value="P:SA node cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003284">
        <property type="term" value="P:septum primum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086005">
        <property type="term" value="P:ventricular cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060412">
        <property type="term" value="P:ventricular septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000001">
        <property type="entry name" value="Gap junction alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002264">
        <property type="entry name" value="Connexin40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034634">
        <property type="entry name" value="Connexin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031862">
        <property type="entry name" value="Cx40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF13">
        <property type="entry name" value="GAP JUNCTION ALPHA-5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16791">
        <property type="entry name" value="Connexin40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01135">
        <property type="entry name" value="CONNEXINA5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118220">
        <property type="entry name" value="Connexin43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="15">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="16">
        <location>
            <begin position="168"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="329"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="369" mass="41715" checksum="B485A89C271D11D9" modified="2020-06-17" version="1">MGDWSFLGEFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQSDFMCDTRQPGCENVCYDKAFPISHIRYWVLQIIFVSTPSLLYMGHAMHTVRMEEKRKLKEAKEAATAIQSKGDSFHQQEYQAPEKAELSCWDEPSGRIILQGTLLNTYVCSILIRTTMEVAFIIGQYMLYGIFLETLYICQRKPCPHPVNCYVSRPTEKNIFIIFMLAVAALSLFLSLAELYHLGWKKAKQKFSPSYKRSPSPVASKLETDPQAKMIQSCTPPPDFNQCLANPGGKFISPFSNKMASQQNTANFATERVHNQDDADREAPFIQVNYSQASEAANSSTPNLVPNGYFHDKRRLSKTSRASSKARSDDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HN23</accession>
    <name>A0A670HN23_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Spastin</fullName>
            <ecNumber evidence="10">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SPAST</name>
        <name evidence="10" type="synonym">SPG4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
            <location evidence="10">Microtubule organizing center</location>
            <location evidence="10">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <text evidence="10">Forms an intramembrane hairpin-like structure in the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AAA ATPase family. Spastin subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A670HN23"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001125.1">
        <property type="protein sequence ID" value="ENSPMRP00000001063.1"/>
        <property type="gene ID" value="ENSPMRG00000000781.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156258"/>
    <dbReference type="OMA" id="MAVTEMR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031117">
        <property type="term" value="P:positive regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02679">
        <property type="entry name" value="MIT_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19524">
        <property type="entry name" value="RecA-like_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000036">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000006">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03021">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017179">
        <property type="entry name" value="Spastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="10">
        <location>
            <begin position="87"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="114"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="340"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="348"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="582" mass="63184" checksum="B2F5B9074BBAE5F6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HN48</accession>
    <name>A0A670HN48_PODMU</name>
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        <submittedName>
            <fullName evidence="6">Calcium binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CABP2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSPMRT00000000991.1">
        <property type="protein sequence ID" value="ENSPMRP00000000936.1"/>
        <property type="gene ID" value="ENSPMRG00000000695.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159796"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="calcium-binding protein 1 isoform X1"/>
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        <property type="entry name" value="calcium-binding protein 1 isoform X2"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="CaBP1/2/4/5"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45917:SF10">
        <property type="entry name" value="CALCIUM BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45917">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand_7"/>
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    </dbReference>
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    </dbReference>
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            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
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            <end position="182"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="215" mass="24411" checksum="B683F4CCB0B9B255" modified="2020-06-17" version="1">MNFSVRKMENKQPSAEAPGSPASTSNDMDEGADGTQYPPLQNYSVLHGLVGPACIFLRQSIAITQIDRELRPEEIEELKEAFREFDKDHDGYISYKDLGECMRTMGYMPTEMELIELSQQITGGKVDFDDFVELMGPKMLAETADMIGVKELRDAFREFDTNGDGQISIAELREAMRKLLGQQLNYREVDEILKDVDLNGDGLVDFEEFVRMMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNY6</accession>
    <name>A0A670HNY6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein RFP-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ohanin/vespryn family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HNY6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000782.1">
        <property type="protein sequence ID" value="ENSPMRP00000000737.1"/>
        <property type="gene ID" value="ENSPMRG00000000545.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234669"/>
    <dbReference type="OMA" id="YEEGIWA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19762">
        <property type="entry name" value="Bbox2_TRIM7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16594">
        <property type="entry name" value="RING-HC_TRIM7-like_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12888">
        <property type="entry name" value="SPRY_PRY_TRIM7_like"/>
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    </dbReference>
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        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
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        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
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        <property type="entry name" value="TRIM/RBCC"/>
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    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="139"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37412" checksum="5C3D337C2A864622" modified="2020-06-17" version="1">MAVSGGPVQSLCDEATCSICLEYFKDPVTIPECGHNFCRSCLVQCWGKLEAEASCPQCRITVQPRSLISNRQLANAVEIAKKLSLPLQEGKVCEKHQETLKLFCKVDATLICVVCDRSKEHENHKVIPLEEASEEYKTKNSQEEKTSDSASLLFPTANVTLNPDTAHPKLILSEDRKSVRWGDKKQALPDNPERFNDWPSVLGREGFTAGRHFWEVTVGSEGEWAVGVARKSLRRKDDFLMRIINTFCDYEEGIWAVGKLRGKYTACTSPDSSPLSLSEEPRRIRVTLDCEAGEISFTGADSGAELYTFSGASFSGETFLPFFYLRGDKIHLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQ21</accession>
    <name>A0A670HQ21_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine rich repeat containing 32</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQ21"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001739.1">
        <property type="protein sequence ID" value="ENSPMRP00000001636.1"/>
        <property type="gene ID" value="ENSPMRG00000001213.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163623"/>
    <dbReference type="OMA" id="CIRRQKF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000226">
        <property type="entry name" value="leucine-rich repeat-containing protein 32 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017241">
        <property type="entry name" value="Toll-like_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037595">
        <property type="entry name" value="Toll-like_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="83554" checksum="2E52F8F5D828C5DB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQD7</accession>
    <name>A0A670HQD7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bromodomain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BRD2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homodimer. Interacts with E2F1. Interacts with (acetylated) STAT3; promoting STAT3 recruitment to chromatin. Interacts with CTCF; promoting BRD2 recruitment to chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the BET family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQD7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001518.1">
        <property type="protein sequence ID" value="ENSPMRP00000001430.1"/>
        <property type="gene ID" value="ENSPMRG00000001062.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153385"/>
    <dbReference type="OMA" id="GGMDQHT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140033">
        <property type="term" value="F:acetylation-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140015">
        <property type="term" value="F:histone H3K14ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140011">
        <property type="term" value="F:histone H4K12ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140012">
        <property type="term" value="F:histone H4K5ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000330">
        <property type="term" value="P:positive regulation of T-helper 17 cell lineage commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000002">
        <property type="entry name" value="Bromodomain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF240">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="837" mass="91684" checksum="4F20E01083328D89" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRB0</accession>
    <name>A0A670HRB0_PODMU</name>
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        <submittedName>
            <fullName evidence="8">Autophagy related 16 like 2</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">ATG16L2</name>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    </organism>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the WD repeat ATG16 family.</text>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF7">
        <property type="entry name" value="PROTEIN ATG16L2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
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    <feature type="domain" description="Autophagy-related protein 16" evidence="7">
        <location>
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            <end position="213"/>
        </location>
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        </location>
    </feature>
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    </feature>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HS69</accession>
    <name>A0A670HS69_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Geranylgeranyl pyrophosphate synthase</fullName>
            <ecNumber evidence="8">2.5.1.1</ecNumber>
            <ecNumber evidence="7">2.5.1.10</ecNumber>
            <ecNumber evidence="6">2.5.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">GGPS1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19361"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>isopentenyl diphosphate + dimethylallyl diphosphate = (2E)-geranyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22408"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homohexamer; trimer of homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 22">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="8"/>
    <dbReference type="EC" id="2.5.1.10" evidence="7"/>
    <dbReference type="EC" id="2.5.1.29" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A670HS69"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002713.1">
        <property type="protein sequence ID" value="ENSPMRP00000002548.1"/>
        <property type="gene ID" value="ENSPMRG00000001836.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153498"/>
    <dbReference type="OMA" id="ANFAYFW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000009">
        <property type="entry name" value="Geranylgeranyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00062555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00072971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="404" mass="45968" checksum="186F7DCBE60A555D" modified="2020-06-17" version="1">METETRAARGLLGSVVFHPPLLPQPERGHAPPLYYNSRCASGSSEENEKMVRGGGGGGSRREIMEAGVGGARACADRPRWRIFPPIRRRWRLRRKGVGLCAHRHTGLRRAERRGSLRAGGEAAETSEGKQVRTKLSQAFNHWLNVPEDKLQVIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINCANFVYFLGLEKVLTLDHPDAVKVFTRQLLELHKGQGLDIYWRDTYTCPTEAEYKTMVLQKTGGLFGLAVGLMQLFSSYKKDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENVDIKKYCVHYLEDVGSFEYTRKTLKELEAEAYKQIESLGENPELTALLEYLSKMFKDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTC3</accession>
    <name>A0A670HTC3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ERLEC1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HTC3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002993.1">
        <property type="protein sequence ID" value="ENSPMRP00000002791.1"/>
        <property type="gene ID" value="ENSPMRG00000002005.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063603"/>
    <dbReference type="OMA" id="HGKDDIY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904153">
        <property type="term" value="P:negative regulation of retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000001">
        <property type="entry name" value="Endoplasmic reticulum lectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000003">
        <property type="entry name" value="Endoplasmic reticulum lectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025496331" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="31"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="116"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="357"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="528" mass="60462" checksum="C62D3AC41E488083" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HVB8</accession>
    <name>A0A670HVB8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger CCCH domain-containing protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZC3H15</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZC3H15/TMA46 family.</text>
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        <property type="nucleotide sequence ID" value="XM_028747978.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000003032.1"/>
        <property type="gene ID" value="ENSPMRG00000002164.1"/>
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    <dbReference type="KEGG" id="pmua:114606140"/>
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    <dbReference type="GeneTree" id="ENSGT00390000015818"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
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        <property type="entry name" value="ZC3H15/TMA46_C"/>
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        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
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    </dbReference>
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        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
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            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="52"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="358"/>
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        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003032.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="431" mass="48669" checksum="C1971B93AB6CF6C7" modified="2020-06-17" version="1">MPPKKQAPAASGAGNKKADQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQAGQAEGDKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEDLEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCKYFLDAIENNKYGWFWVCPGGGDNCMYRHALPPGFVLKKDKKKEEKEEEISLEDLIEKERAALGANVTKITLESFLAWKKRKRQEKINKAEQDMERRKADFKAGKALVISGREVFEFRPELVDADDEEADDTRYIQGTGEDEVDEQGDVNDVDLNLYVPKAVDETGITVASLERFSTYTSAEKDDNKLSEASGGGLENGEQSDLEADSDMEGTQENGVIDAVPVDENLFTGEDLEELEEELNTLDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXV2</accession>
    <name>A0A670HXV2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UBE2E3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028604064.1">
        <property type="nucleotide sequence ID" value="XM_028748231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HXV2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004833.1">
        <property type="protein sequence ID" value="ENSPMRP00000004534.1"/>
        <property type="gene ID" value="ENSPMRG00000003099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606240"/>
    <dbReference type="KEGG" id="pmua:114606240"/>
    <dbReference type="CTD" id="10477"/>
    <dbReference type="GeneTree" id="ENSGT00940000155392"/>
    <dbReference type="OMA" id="GDRAKHD"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:negative regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="84"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="230" mass="25496" checksum="268C9500B4368296" modified="2020-06-17" version="1">MSVCFVETDQDSVALKALQKFSKMSSDRQRSDDESPSTSSGSSDADQRDPPAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZU8</accession>
    <name>A0A670HZU8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the connexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HZU8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005056.1">
        <property type="protein sequence ID" value="ENSPMRP00000004745.1"/>
        <property type="gene ID" value="ENSPMRG00000003251.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234513"/>
    <dbReference type="OMA" id="QQPNHEN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990349">
        <property type="term" value="P:gap junction-mediated intercellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000001">
        <property type="entry name" value="Gap junction alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF46">
        <property type="entry name" value="GAP JUNCTION BETA-2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0303">Gap junction</keyword>
    <keyword evidence="5" id="KW-1009">Hearing</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="12">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="13">
        <location>
            <begin position="146"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="231" mass="26961" checksum="7234027783EC1D91" modified="2020-06-17" version="1">MDWGTLQGILGGVNQHSTSIGKIWLTVLFIFRIMILVVAAEEVWGDEQDDFVCNTLQPGCKNVCYDHFFPISHIRLWALQLIFVSTPALLVAMHVAYRRHERKKKFRKGDKSCEYKDIEEIKKQKFHIEGPLWWTYTASILFRLIFEASFMYVFYYMYQGYHMPRLLKCSAWPCPNVVDCFVSRPTEKTVFTIFMISVSGICILLNVAELSYLLLKSCMKKSQPKKPLPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5L1</accession>
    <name>A0A670I5L1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Ikaros C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I5L1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007512.1">
        <property type="protein sequence ID" value="ENSPMRP00000007023.1"/>
        <property type="gene ID" value="ENSPMRG00000004776.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157137"/>
    <dbReference type="OMA" id="YITCAAS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000168">
        <property type="entry name" value="zinc finger protein Eos isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="142" mass="15597" checksum="DFB29B7423BD3967" modified="2020-06-17" version="1">LLGQLGLGWGSFSNSSSPVLEESSALSDATYFLWEGPPSNSIKLEMQSDDEESDRKPLRREDGIRGHNEGSSLEEPLTENHEMVENRKIQELSGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGKQLKENVMTAFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5T8</accession>
    <name>A0A670I5T8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ectodysplasin-A receptor-associated adapter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EDARADD</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Brejcha J."/>
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                <person name="Pellitteri-Rosa D."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="PANTHER" id="PTHR28469">
        <property type="entry name" value="ECTODYSPLASIN-A RECEPTOR-ASSOCIATED ADAPTER PROTEIN"/>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Bellati A."/>
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                <person name="Bunikis I."/>
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                <person name="Salvi D."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="535" mass="60366" checksum="0695CA66B51C1270" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="6">Transmembrane protein 241</fullName>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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            <end position="291"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="296" mass="33085" checksum="B7AD57948E699551" modified="2020-06-17" version="1">MYLKRPATGLAFCLFYLSSYFTNKYVLSVLKFTYPTLFQGWQTLVGGFLLHISWKIGWTEISSSSRSEVLSWLPASALFVGIIYAGSRALSRLPIPIFLTLHNAADVIACGIEAFVQKEQTSRLKICRVLTLLVAAGCLPFCDPQFDTDGYFWALIHLLCIGAYKVYYNSWRPNSLSDSQQQYINYAFSVVMLAFASHPAGDLFSALEFPFLYFYRFHSSCFASGLLGFLLTLYTMKLKSNTSSGQYAAWSFLAKVITAALSPFFFEIAMNVPTACCLLLGGFAEASLLYIERTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IAC4</accession>
    <name>A0A670IAC4_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
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        </recommendedName>
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        <name evidence="9" type="primary">PARG</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028729245.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000009255.1">
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        <property type="gene ID" value="ENSPMRG00000005853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597122"/>
    <dbReference type="KEGG" id="pmua:114597122"/>
    <dbReference type="CTD" id="8505"/>
    <dbReference type="GeneTree" id="ENSGT00390000003652"/>
    <dbReference type="OMA" id="QNEGKHM"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nuclear body"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:nucleotide-sugar metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of DNA repair"/>
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    </dbReference>
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        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF15">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="706"/>
        </location>
    </feature>
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            <end position="915"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="460"/>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="984" mass="111513" checksum="ED5F87176050FF46" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBE5</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <organism evidence="2 3">
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <location>
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            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="234" mass="26040" checksum="77D11BBCD9FFD08B" modified="2020-06-17" version="1">VFFFSGRVRLGRWSPPFLLCPVPDTWLGLGDVSAFIFAFTFALARTFAFALAWAFTFTLDRAFIFAFTFALARTFAFTLAWAFTFTFTLDRAFIFAFTFALARAFPSLLPGPGPSPSPWTGPFLHFHSDLGLFFTFALARAFAFALAQAFPSLLPWLGPSPSPWPRPSSLPSLLPELRPSPSPWTRPLPFSWPGPSPSPWSGPLPSFWPGPSYSPSPLPWPGPNHNNYNNNKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICH2</accession>
    <name>A0A670ICH2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prolactin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PRL</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the somatotropin/prolactin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ICH2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010040.1">
        <property type="protein sequence ID" value="ENSPMRP00000009411.1"/>
        <property type="gene ID" value="ENSPMRG00000006315.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182818"/>
    <dbReference type="OMA" id="EVYSRWS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001937">
        <property type="term" value="P:negative regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902895">
        <property type="term" value="P:positive regulation of miRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038161">
        <property type="term" value="P:prolactin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031667">
        <property type="term" value="P:response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10288">
        <property type="entry name" value="prolactin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000003">
        <property type="entry name" value="Prolactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001400">
        <property type="entry name" value="Somatotropin/Prolactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018116">
        <property type="entry name" value="Somatotropin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11417:SF5">
        <property type="entry name" value="PROLACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11417">
        <property type="entry name" value="SOMATOTROPIN,PROLACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00103">
        <property type="entry name" value="Hormone_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00836">
        <property type="entry name" value="SOMATOTROPIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00266">
        <property type="entry name" value="SOMATOTROPIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00338">
        <property type="entry name" value="SOMATOTROPIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="181" mass="21022" checksum="17B67F5042878E4B" modified="2020-06-17" version="1">FDRAVKLSHYIHSLSSEMFNEFDERYAQGRGFIAKAINSCHTSSLTTPEDKEQAQQIHHEDLLNLVLSVLRSWNDPLLHLVSEVQRIKEAPDTILWKAMEIEEQNKRLLDGMEKIVGRVHPGDLGNEVYSRWSGLPSLQLADEDSRLFAFYNLLHCLRRDSHKIDSYLKLLKCRLIHDSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDJ7</accession>
    <name>A0A670IDJ7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GEM</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with Calmodulin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028592338.1">
        <property type="nucleotide sequence ID" value="XM_028736505.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592339.1">
        <property type="nucleotide sequence ID" value="XM_028736506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IDJ7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010425.1">
        <property type="protein sequence ID" value="ENSPMRP00000009781.1"/>
        <property type="gene ID" value="ENSPMRG00000006547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600422"/>
    <dbReference type="KEGG" id="pmua:114600422"/>
    <dbReference type="CTD" id="2669"/>
    <dbReference type="GeneTree" id="ENSGT00940000157830"/>
    <dbReference type="OMA" id="IRDHCMQ"/>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04148">
        <property type="entry name" value="RGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000311">
        <property type="entry name" value="GTP-binding protein RAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017358">
        <property type="entry name" value="RGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF4">
        <property type="entry name" value="GTP-BINDING PROTEIN GEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038017">
        <property type="entry name" value="GTP-binding_GEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="296" mass="34039" checksum="D99C4BC45E7F9E2A" modified="2020-06-17" version="1">MTLNNVTMRHSSNTLQSQQQRWSIPADGRNLVVQKDPHECNRHKRYTVNPEEYYRRSWSSESSDSVISSESGNTYYRVVLIGEQGVGKTTIANIFAGVHDSMDSDCEVLGEDTYERTLLVDGESATIILIDMWENKGENGWLQDHCMQVGDAYLIVYSITDRASFERASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDSKEKNERRLAYQKRRESIPKKARRFWGKIVAKKNKNMAFKLKSKSCHDLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IED3</accession>
    <name>A0A670IED3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IED3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010775.1">
        <property type="protein sequence ID" value="ENSPMRP00000010111.1"/>
        <property type="gene ID" value="ENSPMRG00000006755.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="WISSELC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="502"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1263" mass="150026" checksum="7F8205972E427CE0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFS3</accession>
    <name>A0A670IFS3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Papilin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114599865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the venom Kunitz-type family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IFS3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011307.1">
        <property type="protein sequence ID" value="ENSPMRP00000010598.1"/>
        <property type="gene ID" value="ENSPMRG00000007050.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164331"/>
    <dbReference type="OMA" id="KECEHAC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000005">
        <property type="entry name" value="Pancreatic trypsin inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000004">
        <property type="entry name" value="Tissue factor pathway inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000011">
        <property type="entry name" value="Tissue factor pathway inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="221"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="277"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="333"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="389"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="8">
        <location>
            <begin position="441"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="524" mass="58935" checksum="48B535D84B29F757" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGB1</accession>
    <name>A0A670IGB1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon-inducible GTPase 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114603434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598255.1">
        <property type="nucleotide sequence ID" value="XM_028742422.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028598256.1">
        <property type="nucleotide sequence ID" value="XM_028742423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IGB1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011815.1">
        <property type="protein sequence ID" value="ENSPMRP00000011060.1"/>
        <property type="gene ID" value="ENSPMRG00000007384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603434"/>
    <dbReference type="KEGG" id="pmua:114603434"/>
    <dbReference type="GeneTree" id="ENSGT00950000183007"/>
    <dbReference type="OMA" id="GYRHSFG"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04104">
        <property type="entry name" value="p47_IIGP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000541">
        <property type="entry name" value="Immunity related GTPase M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF17">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="5">
        <location>
            <begin position="57"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="412" mass="45227" checksum="8AD6736BD7A175FB" modified="2020-06-17" version="1">MAVQPPPDSQKQAAAYAEEYVKISEEEIEEIRDALEGGRMAEAASKILENLQALENARLDIAVTGESGSGKSSFVNAIRGLGDEDEGSADTGVVETTKEPTPYSHPKHPNVTVWDLPGIGTPDFQSSTYLEQVNFSRYDFFILIASERFKSNHAQLAQEIQRMGKCFYFVRSKVDADLEATKKRRPKAYDEEAILRKIRENCKECLQAEGVAAPQVFLLSSWELNKYDFIQLEETLEKELPSHKRHAFLMALPNISLSILQKKKEALQKQIWKLAAVSCGIAAVPIPGLSVACDIAILVKSLSGYCQNFGLDDESLGKLAEKVDKTVEELKEVIESPLAKEISKDLVVTMLTKAGGGALMVVEYAVSTIPVFGSVAAGGISFGTTYYMLRSFLNEVAGDAQNVLIKAFESDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGT7</accession>
    <name>A0A670IGT7_PODMU</name>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <sequence length="760" mass="83424" checksum="3914AC8D52F62AEB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHU5</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="15" type="primary">SIM1</name>
    </gene>
    <organism evidence="15 16">
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="gene ID" value="ENSPMRG00000007689.1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:ureteric bud development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SIM bHLH transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="single-minded homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PAS_fold"/>
    </dbReference>
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        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010578">
        <property type="entry name" value="SIM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF22">
        <property type="entry name" value="SINGLE-MINDED HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06621">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51302">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="120"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Single-minded C-terminal" evidence="14">
        <location>
            <begin position="379"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="569"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="670"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="2">Belongs to the AKAP110 family.</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IIV3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012728.1">
        <property type="protein sequence ID" value="ENSPMRP00000011918.1"/>
        <property type="gene ID" value="ENSPMRG00000007964.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="IRNANIM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="653" mass="75798" checksum="758656E009432431" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJ07</accession>
    <name>A0A670IJ07_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mesencephalic astrocyte derived neurotrophic factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MANF</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARMET family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028574542.1">
        <property type="nucleotide sequence ID" value="XM_028718709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IJ07"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012855.1">
        <property type="protein sequence ID" value="ENSPMRP00000012040.1"/>
        <property type="gene ID" value="ENSPMRG00000008043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591551"/>
    <dbReference type="KEGG" id="pmua:114591551"/>
    <dbReference type="CTD" id="7873"/>
    <dbReference type="GeneTree" id="ENSGT00390000007160"/>
    <dbReference type="OrthoDB" id="5597848at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000003">
        <property type="entry name" value="Mesencephalic astrocyte-derived neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000003">
        <property type="entry name" value="Mesencephalic astrocyte-derived neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045333">
        <property type="entry name" value="ARMET-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019345">
        <property type="entry name" value="ARMET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045332">
        <property type="entry name" value="ARMET_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990">
        <property type="entry name" value="ARMET-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990:SF10">
        <property type="entry name" value="MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10208">
        <property type="entry name" value="ARMET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20145">
        <property type="entry name" value="ARMET_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ARMET N-terminal" evidence="7">
        <location>
            <begin position="144"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET C-terminal" evidence="6">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="297" mass="33631" checksum="D300AE9E3DA9F2F2" modified="2020-06-17" version="1">MAISASLHLCRKLLGLRRWARLALKVRDDCLFSFGGGLSNRRPPTLLSRKPAWPTGKGSVETCNGALQWQPRTWQEEGQRSQSGCEWAASVSSRCRLWRGFFQYEPSERPRRAVRGRMRAANGLWAALALILLPGESHALREGDCEVCVSFLGRFYQSLKEKNVEFTPNSIEKELLKSCKEAKGKENRLCYYIGATSDAATKITNEVSKPLSNHIPVDKVCEKLKKKDSQICDLKYDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPQYAPKAASSRTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJE4</accession>
    <name>A0A670IJE4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IJE4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012975.1">
        <property type="protein sequence ID" value="ENSPMRP00000012155.1"/>
        <property type="gene ID" value="ENSPMRG00000008130.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154136"/>
    <dbReference type="OMA" id="SHCTTIN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="361" mass="41588" checksum="AE03137BBCE7C602" modified="2020-06-17" version="1">MSFRVHAHFFSDIGAVVPHDILVKKLVKCGLDYATTQWICNWLTDRTQRVLINGSSSSWRRVTSGVPQGSVLGPVLFNIFINDLDDGLKGILIKFADDTKLGGVANTPEDRITLQNDLDRLENWAKTNKMNFNREKCKVLHLGKKSERHKYKMGDTWLESSTCEKDLGVLVDHKLDMSQQCDAAAKKANAILGLINRSIASRSREVIVPLYSALVRPHLEYCVQFWAPQFKKDTDKLERVQRRATKMVKGLEMMPYEERLRELGMFSLEKRRLRGDMIAMFKYIKGCHIEEGERLFSAAPEKRTRSNGSKLQERRFHLNIRKNFLTVRAVRQWNLLPRSVVESPSLEVFKQRLDNHMSGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILC1</accession>
    <name>A0A670ILC1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MEIOSIN</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
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</entry>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Genethonin-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glycophagy cargo receptor stbd1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">STBD1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with the ATG8 family proteins GABARAP and GABARAPL1. Interacts with several glycogen-associated proteins, such as GYS2 (liver glycogen synthase), GDE (glycogen debranching enzyme), GBE1 (glycogen branching enzyme 1) and EPM2A (Laforin).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <location evidence="2">T-tubule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Preautophagosomal structure membrane</location>
            <topology evidence="4">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028600257.1">
        <property type="nucleotide sequence ID" value="XM_028744424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IN01"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014427.1">
        <property type="protein sequence ID" value="ENSPMRP00000013508.1"/>
        <property type="gene ID" value="ENSPMRG00000009048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604373"/>
    <dbReference type="KEGG" id="pmua:114604373"/>
    <dbReference type="CTD" id="8987"/>
    <dbReference type="GeneTree" id="ENSGT00390000007731"/>
    <dbReference type="OMA" id="HYIPLRC"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038024">
        <property type="term" value="F:cargo receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061753">
        <property type="term" value="P:substrate localization to autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05813">
        <property type="entry name" value="CBM20_genethonin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034838">
        <property type="entry name" value="CBM20_genethonin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15048">
        <property type="entry name" value="STARCH-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15048:SF0">
        <property type="entry name" value="STARCH-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="11">
        <location>
            <begin position="233"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="333" mass="36821" checksum="9280F7F31EF3C375" modified="2020-06-17" version="1">MAAAGEEGGDAPATPLRPAPHPLGDGGGGGEPAAGLWPALLVALVAALLAWLWYGRGDGKGKEEEAGGSPQRQRGDRESLQRSYEPAIPETKPISVSSPREPVGNQLGPPGEHSSPDVPGEFPEREHPAEEPTTPLMNYKEYLRNEAFGYPTTAPQQSPEAEVHEASSSAEASAPSDKHEETFTEQRCHHSVDHEEWEIVPEHSAWGEATRKSSVDDASSKDPEQAKRVAAVSPMPQTVHVTFRVHYITHSEAQLIAITGDHECLGQWHHYVPLRCDKDGFWSDSVVLPVDTRVEWKFIVVENGKVRRWEECDNRTLMTEHEDRVAHKWWGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IN41</accession>
    <name>A0A670IN41_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IN41"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014250.1">
        <property type="protein sequence ID" value="ENSPMRP00000013350.1"/>
        <property type="gene ID" value="ENSPMRG00000008928.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="KEAWCAV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="412" mass="47865" checksum="CADF44C1BAAEDF49" modified="2020-06-17" version="1">MLKILQGRLKQYVDRELPEVQAGFRRGRGTRDQIANMRWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEAKVRTGYGTTDWFKIGKGVRQGCILSPCLFNLYAEFIMRKAGLDETQAGIKIAGRNINNLRYADDTTLMAESEEDLKNLLMRVKEESAKYGLKLNIKKTKIMATGPITSWQIEGEEMEAVRDFIFLGSMITADGDSSHEIKRRLLLGRKAMANLDNILKSRAITLPTKVRIVKAMVFPVVMYGSESWTIKKADRRRIDAFELWCWRRLLRVPWTAIRSNTSILKEIRPECSLEGQIVKLRLQYFGHLMRREDSLEKTLMLGKMEGTRRRGRQRMRWLDSVLEATNMSLTKLREAVEDRSAWRALVHGVAKSRTRLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IPN0</accession>
    <name>A0A670IPN0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IPN0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014558.1">
        <property type="protein sequence ID" value="ENSPMRP00000013626.1"/>
        <property type="gene ID" value="ENSPMRG00000009136.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000014567.1">
        <property type="protein sequence ID" value="ENSPMRP00000013635.1"/>
        <property type="gene ID" value="ENSPMRG00000009142.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162732"/>
    <dbReference type="OMA" id="PHRTAIS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="61" mass="7103" checksum="CA747FA0867E872B" modified="2020-06-17" version="1">MSLEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDACVWEDNWNDDNVEDDFSSHLIAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IR36</accession>
    <name>A0A670IR36_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized LOC114603058</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114603058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028597606.1">
        <property type="nucleotide sequence ID" value="XM_028741773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IR36"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014606.1">
        <property type="protein sequence ID" value="ENSPMRP00000013672.1"/>
        <property type="gene ID" value="ENSPMRG00000009165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603058"/>
    <dbReference type="KEGG" id="pmua:114603058"/>
    <dbReference type="GeneTree" id="ENSGT00940000153599"/>
    <dbReference type="OMA" id="CPEASRT"/>
    <dbReference type="OrthoDB" id="5945173at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd23557">
        <property type="entry name" value="TFP_LU_ECD_uPAR_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23558">
        <property type="entry name" value="TFP_LU_ECD_uPAR_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050918">
        <property type="entry name" value="CNF-like_PLA2_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914">
        <property type="entry name" value="LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914:SF25">
        <property type="entry name" value="PHOSPHOLIPASE A2 INHIBITOR AND LY6_PLAUR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025392356" evidence="6">
        <location>
            <begin position="20"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="7">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="7">
        <location>
            <begin position="113"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="7">
        <location>
            <begin position="208"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="717" mass="74023" checksum="D7533EA945147CC6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITU6</accession>
    <name>A0A670ITU6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein SNAI2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein snail homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SNAI3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ITU6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015917.1">
        <property type="protein sequence ID" value="ENSPMRP00000014904.1"/>
        <property type="gene ID" value="ENSPMRG00000009942.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154511"/>
    <dbReference type="OMA" id="PWDRSSA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000085">
        <property type="entry name" value="Snail zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000942">
        <property type="entry name" value="Snail zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001114">
        <property type="entry name" value="Zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF40">
        <property type="entry name" value="ZINC FINGER PROTEIN SNAI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="282" mass="31163" checksum="E4BD7F0A8462C02D" modified="2020-06-17" version="1">MPRSFLVKKPSSTRVPNYGQLETRRQGKEGRNGLRPGRTAPGSLWDHNSAIACLSPPLPQSSEAKGEPTSISQVGSGSSPGGSWDSATPLRDNQNNLNLPLAFSLFQRRTPNLGSPAEGNGDKLQGPQGIAADPLETFECPDCRKAYSTFSGLARHRQQRCKLQATTARKYFNCKHCDKEYASLGALKMHIRTHTLPCMCKICGKAFSRPWLLQGHIRTHTGEKPYACSHCSRAFADRSNLRAHLQTHSDIKKYQCHTCLKTFSRMSLLLRHEETACCPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUK0</accession>
    <name>A0A670IUK0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Aminopeptidase</fullName>
            <ecNumber evidence="24">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">ENPEP</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Venom protein that cleaves N-terminal acidic residues from peptides with high potency in presence of calcium. It may have several roles in venom including alteration of blood pressure by cleaving circulating angiotensin-2, general degradation of host tissue, increase of permeability to other venom components, and/or processing of other toxins in the venom.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.</text>
            <dbReference type="EC" id="3.4.11.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22 24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22 24">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="24"/>
    <dbReference type="RefSeq" id="XP_028599887.1">
        <property type="nucleotide sequence ID" value="XM_028744054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IUK0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015869.1">
        <property type="protein sequence ID" value="ENSPMRP00000014857.1"/>
        <property type="gene ID" value="ENSPMRG00000009915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604179"/>
    <dbReference type="KEGG" id="pmua:114604179"/>
    <dbReference type="CTD" id="2028"/>
    <dbReference type="GeneTree" id="ENSGT00940000156946"/>
    <dbReference type="OMA" id="WNVWSQF"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004230">
        <property type="term" value="F:glutamyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002003">
        <property type="term" value="P:angiotensin maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032835">
        <property type="term" value="P:glomerulus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000003">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF276">
        <property type="entry name" value="GLUTAMYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 24" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 22 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 24" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 24" id="KW-0645">Protease</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 22 24" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="28">
        <location>
            <begin position="104"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="26">
        <location>
            <begin position="326"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="27">
        <location>
            <begin position="622"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="362"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="893"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="23">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00055404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="959" mass="109425" checksum="BCE97CB410C1A4B7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXW6</accession>
    <name>A0A670IXW6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FBXO47</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IXW6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017118.1">
        <property type="protein sequence ID" value="ENSPMRP00000016037.1"/>
        <property type="gene ID" value="ENSPMRG00000010711.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014175"/>
    <dbReference type="OMA" id="AFACVTM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd22112">
        <property type="entry name" value="F-box_FBXO47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056622">
        <property type="entry name" value="ARM_FBXO47"/>
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        <property type="entry name" value="F-box-like_dom_sf"/>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
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        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="450" mass="51369" checksum="75DF2077EAE6CCA4" modified="2020-06-17" version="1">MTYPARTSYTLIPNQKYRRSYRRSSKFSSTLDADSPSLSTLGDFKALPLEIFQMVLEYLPVKDISMLSMVSKTISSRLINYISTPTGNRRLLRQDFHNPELSGCRKGYSMLEHYKSLGLLLKRCTLLLPTKERLKYIHKILSEISCFKFSGCSDPFHCLGLQCYGVFLQTLTAGWDELECHRVYNFLCELSNLPRRVQTVVGSKPGSARKLELRIRIFCRSVLLTHWIHRSDSAFWLTRILKPWPMVNQARLLYILFGPASNLDGHVVWQKTTDGPADEISLKGLADAIKLLYDTEAKEWTADDVISLLDELSVVPRDWLLENSARLLILCGNNICFTFMASKAVNGRAIELARLVVFLALVCEKDLYCMDWAVKMMQKVCKVFSTPGERNNFLQGVENSFAHIIMDALQSVISGEHDEEDSSFLNLFHLVNAQANFHKEILYLAMSNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IYB0</accession>
    <name>A0A670IYB0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanylate cyclase soluble subunit alpha-2</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GUCY1A2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has guanylyl cyclase on binding to the beta-1 subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028582023.1">
        <property type="nucleotide sequence ID" value="XM_028726190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IYB0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017483.1">
        <property type="protein sequence ID" value="ENSPMRP00000016384.1"/>
        <property type="gene ID" value="ENSPMRG00000010932.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595672"/>
    <dbReference type="KEGG" id="pmua:114595672"/>
    <dbReference type="CTD" id="2977"/>
    <dbReference type="GeneTree" id="ENSGT00940000157765"/>
    <dbReference type="OMA" id="CQEVGSE"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007263">
        <property type="term" value="P:nitric oxide mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010750">
        <property type="term" value="P:positive regulation of nitric oxide mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1520.10:FF:000003">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF7">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="524"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="465"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="735" mass="81903" checksum="80E4B53345AFE738" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IYE4</accession>
    <name>A0A670IYE4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glucose-6-phosphatase catalytic subunit 1</fullName>
            <ecNumber evidence="5">3.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Glucose-6-phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + H2O = D-glucose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16689"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="3.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glucose-6-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.9" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670IYE4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018126.1">
        <property type="protein sequence ID" value="ENSPMRP00000017015.1"/>
        <property type="gene ID" value="ENSPMRG00000011289.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183150"/>
    <dbReference type="OMA" id="IPYCISW"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004346">
        <property type="term" value="F:glucose-6-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048878">
        <property type="term" value="P:chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03381">
        <property type="entry name" value="PAP2_glucose_6_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000010">
        <property type="entry name" value="Glucose-6-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016275">
        <property type="entry name" value="Glucose-6-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12591">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12591:SF3">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000905">
        <property type="entry name" value="Glucose-6-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="19">
        <location>
            <begin position="102"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="401" mass="45713" checksum="DFB3F9CF1EAE8A4E" modified="2020-06-17" version="1">MLQPLSIFFWRGEAVKDQRSGVSDTIKAQWLGKRARAKVGEDNPCRSCTMDLLHSAGVQATSYLQENFMGYQDWFVFVSTVADLKTTFFVFFPIWFQLKEEVGIRLIWVAVIGDWLNLVFKWILFGQRPYWWVRETDYYGTATPPAIQQFPNTCETGPGSPSGHAMGSSGVYYVMVTALLSQLLPLQKETLAARCLRGLLWAGFWTVQVCVCLSRVFLAAHFPHQVISGVISGMLVAVFFEHVRSIYNASLRRYVGTTFFLFGFALGFYLLLKMLGVDLLWTLEKAHKWCERPEWVHIDTTPFASLLRNLGILLGLGLGLNSPMYAQSCKGKQRQRLAFRLSCIVCSLSVLHLFDSFELPTDREILFYTLSFCRNTCAHICAVALIPYCISWLFWQTKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J0S4</accession>
    <name>A0A670J0S4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J0S4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018899.1">
        <property type="protein sequence ID" value="ENSPMRP00000017751.1"/>
        <property type="gene ID" value="ENSPMRG00000011724.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182788"/>
    <dbReference type="OMA" id="WITIILH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="155"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="419" mass="46317" checksum="84A78312335AA588" modified="2020-06-17" version="1">MQLHPFLRSVSFNNSAGETVSFSANREVEAGFDITNLVTFPNNSFMRVKVGRVGGEAAAGQEFTLEDNRMVWHRSFHQGPPLSVCNPNCPPGSRKEKKEGEPFCCYGCAPCPQGKISSEKDMVDCVACPEDHYPHRNQSQCVPKTISFLSVKEPLGMSLALIALSLSLLTLVVLVIFIKHQNTPLVRANNRDLTYTLLTFLLLCFLCPLIFLSPPERVSCLLRQMAFGLVFTVTVSCVLAKTITVVLAFVATKPGSRMRKWVGKRLASSIVFSCSLIQVGICTVWLGTSPPFPDSDMHSVMREIILGCNEGSVALFYCVLGYMGFLAIISFVVAFLARKLPESFNEAKFITFSMFLFCSVWISFVPVYLSTKGKYMVAVEIFSILASSAGLLGSIFAPKCYIIVLRPDLNSKECLIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1A9</accession>
    <name>A0A670J1A9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial glutathione transporter SLC25A40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC25A40</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glutathione(in) = glutathione(out)</text>
            <dbReference type="Rhea" id="RHEA:74819"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J1A9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018243.1">
        <property type="protein sequence ID" value="ENSPMRP00000017127.1"/>
        <property type="gene ID" value="ENSPMRG00000011354.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160249"/>
    <dbReference type="OMA" id="YWWGYES"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034634">
        <property type="term" value="F:glutathione transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF5">
        <property type="entry name" value="MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A40-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="276" mass="30535" checksum="CCC3E9287078A2AD" modified="2020-06-17" version="1">IMGSEEKENELYRITTSQQAFSSGCGAVITSVLVTPLDVVKVRLQAQSNPNLKGKILIDIEGVKSLWSGLFPSLAVSVPTTVVYFTCYDQLHDTFGSKIGEDHDSVPLIAGGLARLCAATATSPIEMIKTRMQSRRLSYKKLLACISSNVTQSGWLSLWKGWGPTVLRDVPFSALYWCNYEYLKKRLCKKLGKREPTFLITFSSGAVAGSIAAVLTLPFDVVKTHKQTEMWEPVSTHGIIPRLTKIAPACAIMISAYEYGKSFFRRINKDKAMKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J244</accession>
    <name>A0A670J244_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPS7</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J244"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018560.1">
        <property type="protein sequence ID" value="ENSPMRP00000017432.1"/>
        <property type="gene ID" value="ENSPMRG00000011523.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014122"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990948">
        <property type="term" value="F:ubiquitin ligase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000059">
        <property type="term" value="P:negative regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014033">
        <property type="term" value="P:neural crest cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902255">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="197" mass="22315" checksum="35BCDB56F32BE034" modified="2020-06-17" version="1">MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVRKGISVAQWVYLLTRSLVSLSPPRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J287</accession>
    <name>A0A670J287_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">5'-nucleotidase</fullName>
            <ecNumber evidence="14">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NT5C3B</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>CMP + H2O = cytidine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="3.1.3.91"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(7)-methyl-GMP + H2O = N(7)-methylguanosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:20794"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="EC" id="3.1.3.91"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028559945.1">
        <property type="nucleotide sequence ID" value="XM_028704112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J287"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018792.1">
        <property type="protein sequence ID" value="ENSPMRP00000017649.1"/>
        <property type="gene ID" value="ENSPMRG00000011660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582813"/>
    <dbReference type="CTD" id="115024"/>
    <dbReference type="GeneTree" id="ENSGT00390000012959"/>
    <dbReference type="OMA" id="THFISNM"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07504">
        <property type="entry name" value="HAD_5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.340:FF:000001">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000032">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01544">
        <property type="entry name" value="HAD-SF-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF15">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="298" mass="34018" checksum="301E47D0FC0F3EA7" modified="2020-06-17" version="1">MVPELEKATVRMKDPERVKNVISALRKGGVGKFQVISDFDMTLTRFGFNGRRCPTSYNIIDNSRVISEEGKKKLKDLLQHYYPIEIDPYRTMEDKLPLMIEWWTKAHDLLAQQKIKKSDIAQVVKESDVMLRDGFNILFDQLHQNKVPLFIFSAGVGDVLEEIIHQAGAFYPNVNVVSNYMDFDDSGVLRGFKEPLIHTYNKNNTVLKDTEYFQQLCTRTNILLLGDSMGDLSMADGVVDVENILRVGFLNDRVEEQRGKYLEAYDIVLEKDETLDVANGILRFVLAETAQATQPTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2I3</accession>
    <name>A0A670J2I3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Gamma-aminobutyric acid type A receptor subunit gamma1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GABRG1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028600089.1">
        <property type="nucleotide sequence ID" value="XM_028744256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J2I3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019554.1">
        <property type="protein sequence ID" value="ENSPMRP00000018390.1"/>
        <property type="gene ID" value="ENSPMRG00000012096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604275"/>
    <dbReference type="CTD" id="2565"/>
    <dbReference type="GeneTree" id="ENSGT00940000160193"/>
    <dbReference type="OMA" id="MGSWEAF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="LGIC_ECD_GABAAR_G"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LGIC_TM_GABAAR_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000003">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit gamma-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005438">
        <property type="entry name" value="GABBAg1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005437">
        <property type="entry name" value="GABRG-1/4"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
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    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01620">
        <property type="entry name" value="GABAARGAMMA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01621">
        <property type="entry name" value="GABAARGAMMA1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025705962" evidence="17">
        <location>
            <begin position="35"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="64"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="276"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="466" mass="53673" checksum="9B14628ACDB0BB27" modified="2020-06-17" version="1">MEPELGACFPSRPWSPRGGARLLLLLLTVRLGSCMDKADDEDDEDLTVNKTWVLAPKIHEGDVTHILNSLLQGYDNKLRPDIGVRTTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWYDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPRNEIIYKWKKSSVEVADPKYWRLYQFAFVGLRNTTDISHTQSGDYVVMTIFFVLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYITAMDLFVSVCFIFVFAALVEYGTLHYFTNNKKGAKEKDKKSKNKSSTPALPVRPGSTLIPINNLRHLQEHHGNYGYECLEGKDCTSFFCCFDDCRTGSWREGRIHIRVAKIDSYSRIFFPTAFALFNLVYWIGYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2W6</accession>
    <name>A0A670J2W6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L27a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J2W6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020011.1">
        <property type="protein sequence ID" value="ENSPMRP00000018838.1"/>
        <property type="gene ID" value="ENSPMRG00000012323.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005534"/>
    <dbReference type="OMA" id="HGRHGNA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="146" mass="16612" checksum="18D92455B8847AC1" modified="2020-06-17" version="1">MPSRLRKTRKLRGHVSHGHGRHGNAGGLHHHRINFDKYHPGYFGKVGMKHYHLKKNQHFCLTVNLDKLWTLVSEQAKLNDAKNQAGLAPVIDVVRSVSQPHSPHRVFVLWGRKGKENVSHFETPSGSDKAEHGLPYTAFKTKITFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J561</accession>
    <name>A0A670J561_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 5 open reading frame 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C5orf24</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0461 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J561"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019572.1">
        <property type="protein sequence ID" value="ENSPMRP00000018407.1"/>
        <property type="gene ID" value="ENSPMRG00000012110.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014889"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040419">
        <property type="entry name" value="DUF5568"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31894">
        <property type="entry name" value="UPF0461 PROTEIN C5ORF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31894:SF0">
        <property type="entry name" value="UPF0461 PROTEIN C5ORF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17724">
        <property type="entry name" value="DUF5568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="380" mass="40264" checksum="4560008B7D9C6967" modified="2020-06-17" version="1">MPQQYRTGSPSQRCGALCGPTSLPHSSSSASEQAAPPPRPSQALSGSPGERPLPLRRPPAAPFLLLLLLTEQPPPLPLPSRRPLPLLLAPAARWPRPGARTSPPRLPAAAPARLSRPAPPSQLLLRWSCSLSPGRLRRRKPAAAGRGPSAPRRVPPTTTTTLVELAPRGPSHQPPPPCPLPSPSALPRIPQKMMHPVASGNSPFCGPGKSSCLNDDNVTPTDQFDLYSTQQTKYSHTVSHKPIPCQRQDALNEPHLQTTSGRSIETKDDIKKKKNLNRSGKRGRPSGTTKSAGYRTSTGRPLGTTKAAGFKTSPGRPLGTTKAAGYKVSPGRPPGSIKALSRLANLSYTCSSAAFPYAVVHNRGVHAAGETSSKIKQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5E6</accession>
    <name>A0A670J5E6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TREX1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670J5E6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019975.1">
        <property type="protein sequence ID" value="ENSPMRP00000018804.1"/>
        <property type="gene ID" value="ENSPMRG00000012304.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012715"/>
    <dbReference type="OMA" id="ICQWRPR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032405">
        <property type="term" value="F:MutLalpha complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032407">
        <property type="term" value="F:MutSalpha complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140896">
        <property type="term" value="P:cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160049">
        <property type="term" value="P:negative regulation of cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000046">
        <property type="entry name" value="Three prime repair exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF27">
        <property type="entry name" value="THREE-PRIME REPAIR EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="13">
        <location>
            <begin position="39"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="360" mass="40874" checksum="F8B5A8249DA5D369" modified="2020-06-17" version="1">MRSIHCIGHLVPFPNFHCSFFLDLRMWPTSVTPSKPIETFVFMDLEATGLPPSQPKIAEMCLFAVSRHSLENPQYSNPRPKPLPLLPRLADKLSVCINPDKLFTPAASSITGLTNEAFAMNRKQTFNLHLLHMIVAFFRRQHPPICLVAHNGYGYDFPLLKAELSALGHLALDEIYCADTIKAMKALDSENNQLQQFAYQPSAPGSRKKYALRDLYFKFYREYPPNSHNAEGDVIALINIFQQRASDLMCWMDSNAIPFNSIRAMYKENERYASFSKTPGNIQPPHSSHLQMQSRQRVAASTSRWPFPEGGEPADNNYIPLSHRSADKYFIIPDEIKSVQGILILFLGLVVMWVAVKYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5N2</accession>
    <name>A0A670J5N2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J5N2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020686.1">
        <property type="protein sequence ID" value="ENSPMRP00000019485.1"/>
        <property type="gene ID" value="ENSPMRG00000012696.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234528"/>
    <dbReference type="OMA" id="DWISSKM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035821">
        <property type="term" value="P:modulation of process of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000004">
        <property type="entry name" value="Tryptase gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050850">
        <property type="entry name" value="Peptidase_S1_Elastase_sf"/>
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        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
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        <property type="entry name" value="Peptidase_S1A"/>
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        <property type="entry name" value="Trypsin_dom"/>
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        <property type="entry name" value="TRYPSIN_HIS"/>
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    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
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        <property type="entry name" value="CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ELASTASE 3 LIKE ISOFORM X1"/>
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    </dbReference>
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        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRYPSIN_SER"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="43"/>
            <end position="284"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019485.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="291" mass="31574" checksum="8A1D6A201D171792" modified="2020-06-17" version="1">MLISVSVSLLPLPNFLFHHPHACCLLPAHGCGKSAYPPNISRVVGGEDARPHSWPWQVSLQYDKNGVWAHTCGGTLIESNWVLTAAHCISSSRTYRVLLGKQNLEVEEAGSVAVAVEKLIVHEKWNSFLVIQLSWGYNDIALLKLAEHVQFSDTIQASCLPAADAVLAQDYPCYITGWGRLWTNGPISDNLQQALLPVVDHQTCTKWDWWGSMVKTTMVCAGGDGVVSGCNGDSGGPLNCQGGSNWEVHGIVSFGSGLGCNTAKKPTVFTRVSAYIDWIHRTPAPLANKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5S8</accession>
    <name>A0A670J5S8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Protein kinase C and casein kinase substrate in neurons 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PACSIN1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J5S8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020110.1">
        <property type="protein sequence ID" value="ENSPMRP00000018934.1"/>
        <property type="gene ID" value="ENSPMRG00000012362.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182973"/>
    <dbReference type="OMA" id="ACQMKEL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030137">
        <property type="term" value="C:COPI-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic vesicle membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:photoreceptor ribbon synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098833">
        <property type="term" value="C:presynaptic endocytic zone"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:phospholipid binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of endocytosis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
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    </dbReference>
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        <property type="term" value="P:plasma membrane tubulation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900006">
        <property type="term" value="P:positive regulation of dendrite development"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11998">
        <property type="entry name" value="SH3_PACSIN1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase C and casein kinase substrate in neurons protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000205">
        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035743">
        <property type="entry name" value="PACSIN1/PACSIN2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF16">
        <property type="entry name" value="PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="18">
        <location>
            <begin position="10"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="386"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="307"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="445" mass="50715" checksum="901A6CCF0838CB25" modified="2020-06-17" version="1">ASGSHTSTLESLCSCVWQVGNYKRTVKRIDDGYRLCNDLMNCVHERAKIEKAYSQQLVDWSKRWRQLIEKGPQYGSLEKAWMAIMTEADKVSELHQEVKNSLLNDDFEKVKNWQKDAFHKQIMGGFKEAKEAEDGFRKAQKPWAKKMKELETAKKAYHLACKEEKLAMTREANSKAEQSITPDQQKKLQDKVEKCKQDVQKTQEKYEKVVDELSKSTPQYMESMEQVFEQCQQFEEKRLIFLKEVLLDIKRHLNLAENNSSYAKVYRELEQTIRAADAQDDLRWFRNTSGPGMPMNWPQVEEWNPDAAAQPVARKEKPPKKNETSNSSNASGGGEAAAQAGDRGSVSSYERSQAYAAEWSDDDGGNTYNSSEANGGANSFEEEPVAKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCKGRLDNGQLGLYPANYVESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J7X5</accession>
    <name>A0A670J7X5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
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        <location>
            <begin position="413"/>
            <end position="674"/>
        </location>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="890" mass="98228" checksum="05B41AD073883F53" modified="2020-06-17" version="1"> </sequence>
</entry>
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            <fullName evidence="6">40S ribosomal protein S4</fullName>
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        <name evidence="9" type="primary">LOC114606585</name>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A670J8B2_PODMU</name>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="component" value="Chromosome 13"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="7tm_4"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="503" mass="55124" checksum="63418622B9CB7054" modified="2020-06-17" version="1">RGQEVVLLSIPIPAAPVGLRTTCIVSPLPKARGIFDPEFYPGITRSGTARRGRSVGPLFLRTPKGTTSYQLPILNPGRQPMPPPYEDDDVQQTLVPFYYQGPPPRAPTPSDSNSSIKHPGQAKTKIPSSTLHNTIEDSTQIGNKPAPTEPYGSATGTLGCDKETPGTSDQVSSTVSSTAVQMPLRALPIPPLVPDGPPRMVYTHQPFYTSDLVTWSNQMPSLRDDPDKCHRQVSAIFSTHNPTWPDVHVLLNALFNEAEKADILTKAGEAIELPDYQRGRPQGLQALTAQCLRVEPAWDYNTTNGIWCLNLFKRAILDGVKAAGQRTVNWTKVQSVMQGPNEHPSDYYTRLVSAIKTWGGIDPENPQHEVIVKGFFKDQACPDIRKALNLQIGYDGKSVSEILSIAKSVYNSRDERKKKETKPEVEQILALSMETIDGHPYQCLLDIGATYSTLTDSHLEPGTVTKKVMGLDGIPRTCPLSRPAKVTLGPLLVEHTFLLTSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAY7</accession>
    <name>A0A670JAY7_PODMU</name>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JAY7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022746.1">
        <property type="protein sequence ID" value="ENSPMRP00000021431.1"/>
        <property type="gene ID" value="ENSPMRG00000013917.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286962"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="269" mass="29708" checksum="EE2111A33EDE88F7" modified="2020-06-17" version="1">MDPDRFRQALQDLSPPGDSLTELELEAPRLSLGPVLDHFDRISPADVDRLLRAGKPTTCPLDPCPSWLIRACPDEVRAPLGDIINLSLGIGTFPGELKEAVVRPLLKKTSLDPLDLSNYRPVSNLPFLGKVIERAAAEQLGRFLDETSALDPFQSGFRAGHGTETALVALTDDLRRQLDRGGSGLLILLDLSAAFDMVDHELLDHLYVQYITIIYLRLTCGGLWRKLESSRKSSTSASLTMQKPLMVSTTAYYGKFLKKWECLITSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JB64</accession>
    <name>A0A670JB64_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polypyrimidine tract-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Neural polypyrimidine tract-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PTBP2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JB64"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022833.1">
        <property type="protein sequence ID" value="ENSPMRP00000021516.1"/>
        <property type="gene ID" value="ENSPMRG00000013963.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244924"/>
    <dbReference type="OMA" id="FKFFQYV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033119">
        <property type="term" value="P:negative regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000177">
        <property type="term" value="P:regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12778">
        <property type="entry name" value="RRM1_PTBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12783">
        <property type="entry name" value="RRM2_PTBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12696">
        <property type="entry name" value="RRM3_PTBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12702">
        <property type="entry name" value="RRM4_PTBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000036">
        <property type="entry name" value="polypyrimidine tract-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000018">
        <property type="entry name" value="Polypyrimidine tract-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000032">
        <property type="entry name" value="Polypyrimidine tract-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000173">
        <property type="entry name" value="polypyrimidine tract-binding protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035002">
        <property type="entry name" value="PTBP2_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034799">
        <property type="entry name" value="PTBP2_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034800">
        <property type="entry name" value="PTBP2_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="222"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="379"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="496"/>
            <end position="570"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="572" mass="62367" checksum="B21C8BFBBD54D9C2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JD88</accession>
    <name>A0A670JD88_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myotrophin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MTPN</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the myotrophin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JD88"/>
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        <property type="protein sequence ID" value="ENSPMRP00000021092.1"/>
        <property type="gene ID" value="ENSPMRG00000013709.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000022397.1">
        <property type="protein sequence ID" value="ENSPMRP00000021094.1"/>
        <property type="gene ID" value="ENSPMRG00000013709.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00430000031071"/>
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</entry>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>IDENTIFICATION</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Golgi apparatus membrane</location>
            <topology evidence="20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="20"/>
    <dbReference type="RefSeq" id="XP_028558864.1">
        <property type="nucleotide sequence ID" value="XM_028703031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JHI7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025371.1">
        <property type="protein sequence ID" value="ENSPMRP00000023911.1"/>
        <property type="gene ID" value="ENSPMRG00000015476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582211"/>
    <dbReference type="KEGG" id="pmua:114582211"/>
    <dbReference type="CTD" id="2589"/>
    <dbReference type="GeneTree" id="ENSGT00940000154732"/>
    <dbReference type="OMA" id="MGQGFAP"/>
    <dbReference type="OrthoDB" id="330637at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000014">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000005">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF123">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 20" id="KW-0430">Lectin</keyword>
    <keyword evidence="18 20" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="22">
        <location>
            <begin position="428"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="559" mass="64136" checksum="AB71E6B7AB81A62B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHL4</accession>
    <name>A0A670JHL4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ankyrin repeat and MYND domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ANKMY2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in the trafficking of signaling proteins to the cilia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028607410.1">
        <property type="nucleotide sequence ID" value="XM_028751577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JHL4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025638.1">
        <property type="protein sequence ID" value="ENSPMRP00000024173.1"/>
        <property type="gene ID" value="ENSPMRG00000015630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607896"/>
    <dbReference type="KEGG" id="pmua:114607896"/>
    <dbReference type="CTD" id="57037"/>
    <dbReference type="GeneTree" id="ENSGT00390000016820"/>
    <dbReference type="OMA" id="EFPFREC"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000182">
        <property type="entry name" value="Ankyrin repeat and MYND domain containing 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000010">
        <property type="entry name" value="Ankyrin repeat and MYND domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052452">
        <property type="entry name" value="Ankyrin-MYND_dom_contain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="14">
        <location>
            <begin position="320"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="370"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="458" mass="51031" checksum="9010A115D9D17066" modified="2020-06-17" version="1">MASLKRGDLSEEEKELLGVIGKGSPEEAARLLGSKNVRVNCLDEHGMTPLMHAAYKGKVEVCKLLLRHGADVNCNEHEHGYTALMFAGLSGNKEITWMMLEAGADTDVVNSVGRTAAQMAAFVGQHDCVTVINNFFPRERLDYYTKPQGLDKEPKLPVKLAGPLHKIITTTNLHPVKIVLLVKENPLLAEVEAMQKCYRVLDLICEKCMKQREMNEVLAIKMHYISCIFQKCILFLKEREDKLDGLIKSLLKGRDADGFPVFQEKFIRECIRKFPYCEATLLQQLVRSIAPVEIGSDPTAFSVLTQAVTGQVGFVDAEFCTTCGGKGAAKRCSVCKMVIYCDQDCQKMHWFTHKKVCKTLKEAHEKQELEAAKAKKQQEAKQKREATHAAESALTSEEQSASEPGDNKEEDLKCVGDRTEEMVPKKEVPALSPQDDKALEGETSLADITVEKAHESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JIL4</accession>
    <name>A0A670JIL4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glypican-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114597755</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JIL4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026127.1">
        <property type="protein sequence ID" value="ENSPMRP00000024626.1"/>
        <property type="gene ID" value="ENSPMRG00000015910.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000026134.1">
        <property type="protein sequence ID" value="ENSPMRP00000024633.1"/>
        <property type="gene ID" value="ENSPMRG00000015910.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244955"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019803">
        <property type="entry name" value="Glypican_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF19">
        <property type="entry name" value="GLYPICAN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01207">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 12" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044625069" evidence="14">
        <location>
            <begin position="33"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="507"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="608" mass="67461" checksum="776685E9633E18AB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJM7</accession>
    <name>A0A670JJM7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">LIF receptor subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LIFR</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605365.1">
        <property type="nucleotide sequence ID" value="XM_028749532.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028605366.1">
        <property type="nucleotide sequence ID" value="XM_028749533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JJM7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026610.1">
        <property type="protein sequence ID" value="ENSPMRP00000025078.1"/>
        <property type="gene ID" value="ENSPMRG00000016207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606890"/>
    <dbReference type="KEGG" id="pmua:114606890"/>
    <dbReference type="CTD" id="3977"/>
    <dbReference type="GeneTree" id="ENSGT00940000155776"/>
    <dbReference type="OMA" id="FFLYGCK"/>
    <dbReference type="OrthoDB" id="6382334at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005127">
        <property type="term" value="F:ciliary neurotrophic factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019955">
        <property type="term" value="F:cytokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004923">
        <property type="term" value="F:leukemia inhibitory factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004924">
        <property type="term" value="F:oncostatin-M receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000607">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000657">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000738">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003529">
        <property type="entry name" value="Hematopoietin_rcpt_Gp130_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048497">
        <property type="entry name" value="LIF-R-like_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040817">
        <property type="entry name" value="LIFR_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040901">
        <property type="entry name" value="LIFR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050379">
        <property type="entry name" value="Type-I_Cytokine_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036:SF105">
        <property type="entry name" value="LEUKEMIA INHIBITORY FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21177">
        <property type="entry name" value="LIF-R_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17971">
        <property type="entry name" value="LIFR_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25552">
        <property type="entry name" value="LIFR_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18207">
        <property type="entry name" value="LIFR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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            <begin position="324"/>
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            <begin position="714"/>
            <end position="822"/>
        </location>
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        <location>
            <begin position="1024"/>
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            <begin position="1024"/>
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        <source>
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        </source>
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        </source>
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    <sequence length="1090" mass="121759" checksum="3B9A14B7FE5C0DED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLF5</accession>
    <name>A0A670JLF5_PODMU</name>
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        <recommendedName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
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        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
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        <property type="gene ID" value="ENSPMRG00000016006.1"/>
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    <dbReference type="GeneTree" id="ENSGT00950000182825"/>
    <dbReference type="OMA" id="YMASCIL"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of cytoskeleton"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="alpha_tubulin"/>
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        <property type="entry name" value="Helix hairpin bin"/>
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    </dbReference>
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        <property type="entry name" value="Alpha_tubulin"/>
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        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
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        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
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        <property type="entry name" value="Tubulin_C"/>
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        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
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        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="450" mass="49960" checksum="2A78714CBA782D55" modified="2020-06-17" version="1">MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEAEAEEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLS2</accession>
    <name>A0A670JLS2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JLS2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025384.1">
        <property type="protein sequence ID" value="ENSPMRP00000023922.1"/>
        <property type="gene ID" value="ENSPMRG00000015473.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165584"/>
    <dbReference type="OMA" id="REVLITH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008392">
        <property type="term" value="F:arachidonate epoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019373">
        <property type="term" value="P:epoxygenase P450 pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF389">
        <property type="entry name" value="CYTOCHROME P450 2C20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="489" mass="55096" checksum="1E0BA8AA72243A76" modified="2020-06-17" version="1">MEVAVTGALFLLWVLFIFISHSLKMYKEKSQLPPGPTPWFFLGNLLQKDVMPLNKNYSKLVEKYGPMFTIWMGPKPMVVLCGFDVVKDALVDHAEAFGGRINSPIIDRVTKGHGSDIEWRELRRFTVMTLRDFGMGKRSMSERVQEEAVCLVEALAATKGNLGFDPTTRITSAVSNVISSVIFGTRFDYTDKTFLKHQRIIENEVGLFHTTLGLLYSAVPKILDCFPGRHQKIFSDCDELCAFVRENVKVHMQTLDPQNIRDYIDCFLIKSEKVCGSKNLTENLVMTVFGLFLAGTGTTSFALISGLMVMAKLPHIQAKVQQEIDEVMSATRAPSMEDRVRMPFTNAVIHEILRYPVLSNETIPHTTSCDTKFRGFTFPKGTAVTPLFTSVHRDPLQWETPEQFNAGHFLDEKGQFKKKDALIVFSAGKRACIGEALAQMELFLFFSTLLQNFTFQLVGAAKDMDLASLFMEFNAKNVCPLMKATRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JMR0</accession>
    <name>A0A670JMR0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JMR0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027297.1">
        <property type="protein sequence ID" value="ENSPMRP00000025716.1"/>
        <property type="gene ID" value="ENSPMRG00000016656.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163466"/>
    <dbReference type="OMA" id="GRWHQTN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000006">
        <property type="entry name" value="collagen alpha-1(XXVII) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="138" mass="15871" checksum="945A960CA45A9A2E" modified="2020-06-17" version="1">MNETKLESQFSPQPPILPFFQLDFDIGRVQLNFLHLLSTEVIQNITIHCLNTSVWQEGPSRKAVHFKAWNGQIFEAGGQFTPDVVVNDCKIQDGHWHRTLFTFRTQDLQQLPITNIYNLPPSEPGKQHLLEVGPMCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JN48</accession>
    <name>A0A670JN48_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JN48"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027403.1">
        <property type="protein sequence ID" value="ENSPMRP00000025821.1"/>
        <property type="gene ID" value="ENSPMRG00000016709.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230359"/>
    <dbReference type="OMA" id="HYTCSPH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000026">
        <property type="entry name" value="C-C chemokine receptor type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002236">
        <property type="entry name" value="Chemokine_CCR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000355">
        <property type="entry name" value="Chemokine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF686">
        <property type="entry name" value="C-C CHEMOKINE RECEPTOR TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00657">
        <property type="entry name" value="CCCHEMOKINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01106">
        <property type="entry name" value="CHEMOKINER1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="36"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="340" mass="38631" checksum="7BB07587A2C91B4A" modified="2020-06-17" version="1">VYDETAEPCPSASVNEFASQFLPPLYSLVLIFGLLGNSLVVLILIRYKKLKSMTDIYLLNLAISDLLFIFTLPFWAYYAAHEWVFGDAMCKILSGIYYVGFYSGSFFIILLTIDRYLAIVHAVFALKARTVTYGILTSVVMWGVALLASVPVMVFNRLQKEDNRSVCTPHFSYENQIVWNQFFTLKMNLIGLIFPMIVMTFCYAQIIKTLMKCRNDKKSKAVRLIFIIMIVYFIFWAPYNIVLLLQTFQDAFDLSNCASISNLAIAAQATETIAMAHCCINPVIYAFAGEKFRKYVCSLFRKHVALHLPKTCLSLYTEPLERASSTYSQSTGEHDMSAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPB0</accession>
    <name>A0A670JPB0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Biogenesis of lysosome-related organelles complex 1 subunit 6</fullName>
            <shortName evidence="5">BLOC-1 subunit 6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BLOC1S6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the BLOC1S6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028561552.1">
        <property type="nucleotide sequence ID" value="XM_028705719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JPB0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026864.1">
        <property type="protein sequence ID" value="ENSPMRP00000025309.1"/>
        <property type="gene ID" value="ENSPMRG00000016383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584151"/>
    <dbReference type="KEGG" id="pmua:114584151"/>
    <dbReference type="CTD" id="26258"/>
    <dbReference type="GeneTree" id="ENSGT00510000047812"/>
    <dbReference type="OMA" id="MMSDVKR"/>
    <dbReference type="OrthoDB" id="19659at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070938">
        <property type="term" value="C:contractile ring"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990742">
        <property type="term" value="C:microvesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046085">
        <property type="term" value="P:adenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002936">
        <property type="term" value="P:bradykinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042745">
        <property type="term" value="P:circadian sleep/wake cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035646">
        <property type="term" value="P:endosome to melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003158">
        <property type="term" value="P:endothelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048872">
        <property type="term" value="P:homeostasis of number of cells"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021854">
        <property type="term" value="P:hypothalamus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033484">
        <property type="term" value="P:intracellular nitric oxide homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:kidney development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032402">
        <property type="term" value="P:melanosome transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007613">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032816">
        <property type="term" value="P:positive regulation of natural killer cell activation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050942">
        <property type="term" value="P:positive regulation of pigment cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein transmembrane transport"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:response to acetylcholine"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033299">
        <property type="term" value="P:secretion of lysosomal enzymes"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042311">
        <property type="term" value="P:vasodilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017242">
        <property type="entry name" value="BLOC-1_pallidin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31328">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31328:SF2">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037609">
        <property type="entry name" value="BLOC-1_complex_pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="177" mass="20605" checksum="BCED28EAA492D9EC" modified="2020-06-17" version="1">MSVCFAREEAMSLADPLDVEAALQTRNDPALDSNDNSPDEGLIEDFAVIDQKAVEQLTEGLISHYLPDLQRSKLSLKELTQNQEVLLETLQQEISKFKECNSVLDINVLFSEAKYYHNKLVNIRKEMLLLHEKTSKLKRRALKLQQKRQKEELEREQQREKELEREKQLTAKPAKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JS24</accession>
    <name>A0A670JS24_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Solute carrier family 25 member 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC25A13</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-alanine(in) + L-aspartate(out)</text>
            <dbReference type="Rhea" id="RHEA:70975"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>3-sulfino-L-alanine(out) + L-glutamate(in) + H(+)(in) = 3-sulfino-L-alanine(in) + L-glutamate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70967"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-aspartate(in) + L-glutamate(out) + H(+)(out) = L-aspartate(out) + L-glutamate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70783"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JS24"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029516.1">
        <property type="protein sequence ID" value="ENSPMRP00000027828.1"/>
        <property type="gene ID" value="ENSPMRG00000017949.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000029528.1">
        <property type="protein sequence ID" value="ENSPMRP00000027839.1"/>
        <property type="gene ID" value="ENSPMRG00000017949.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159344"/>
    <dbReference type="OMA" id="AEAQRQX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000514">
        <property type="term" value="F:3-sulfino-L-alanine: proton, glutamate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000515">
        <property type="term" value="F:aspartate:glutamate, proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051592">
        <property type="term" value="P:response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000064">
        <property type="entry name" value="calcium-binding mitochondrial carrier protein Aralar1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF12">
        <property type="entry name" value="ELECTROGENIC ASPARTATE_GLUTAMATE ANTIPORTER SLC25A13, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="325"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="425"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="517"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="672" mass="74163" checksum="DDBE73D2651C28B2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSK8</accession>
    <name>A0A670JSK8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain 34A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ANKRD34A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKRD34 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566535.1">
        <property type="nucleotide sequence ID" value="XM_028710702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JSK8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028104.1">
        <property type="protein sequence ID" value="ENSPMRP00000026494.1"/>
        <property type="gene ID" value="ENSPMRG00000017128.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586858"/>
    <dbReference type="KEGG" id="pmua:114586858"/>
    <dbReference type="CTD" id="284615"/>
    <dbReference type="GeneTree" id="ENSGT00390000012355"/>
    <dbReference type="OMA" id="PGNLCPD"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042637">
        <property type="entry name" value="AN34A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156:SF4">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 34A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="526" mass="56575" checksum="CF8BA8D19B1D90E8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTJ7</accession>
    <name>A0A670JTJ7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myeloid leukemia factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MLF2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MLF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JTJ7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030169.1">
        <property type="protein sequence ID" value="ENSPMRP00000028441.1"/>
        <property type="gene ID" value="ENSPMRG00000018362.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000030177.1">
        <property type="protein sequence ID" value="ENSPMRP00000028448.1"/>
        <property type="gene ID" value="ENSPMRG00000018362.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000030185.1">
        <property type="protein sequence ID" value="ENSPMRP00000028456.1"/>
        <property type="gene ID" value="ENSPMRG00000018362.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000030191.1">
        <property type="protein sequence ID" value="ENSPMRP00000028462.1"/>
        <property type="gene ID" value="ENSPMRG00000018362.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000030216.1">
        <property type="protein sequence ID" value="ENSPMRP00000028484.1"/>
        <property type="gene ID" value="ENSPMRG00000018362.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005023"/>
    <dbReference type="OMA" id="FDNEWRR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019376">
        <property type="entry name" value="Myeloid_leukemia_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13105">
        <property type="entry name" value="MYELOID LEUKEMIA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10248">
        <property type="entry name" value="Mlf1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="243" mass="27621" checksum="33710C6593A60AD3" modified="2020-06-17" version="1">MFRFMRDGEPEDPMFVMDPLAIHHQHVNRVLSGGFGYSPFLSIGNGTVPATRQTSRRMQAGTVSPFGMLGMAGGFMDMFGMMNDMIGNMEHMTSGSNCQTFTSSTVISYSNLGEGPKVYQETSETRSAPGGIRETRRTVRDSDSGLEQMSIGHHIRERAHIMQRSRNHRTGDQEERQDYINLDESDAAAFDDEWRRETSRFRTQRGLEYRRHEGSNGRRAEGARLAIQGPEDSPTRQSRRYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTS3</accession>
    <name>A0A670JTS3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Granzyme A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114606894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JTS3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027916.1">
        <property type="protein sequence ID" value="ENSPMRP00000026312.1"/>
        <property type="gene ID" value="ENSPMRG00000017020.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159928"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035821">
        <property type="term" value="P:modulation of process of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF69">
        <property type="entry name" value="GRANZYME A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025528907" evidence="8">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="26"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="258" mass="28630" checksum="26A6D348497FE7A7" modified="2020-06-17" version="1">MGVFFDLWFFSAIFLFGIPRDRCADIIGGKESKPHSRPYMALIKGRQICGGTLIKPNWVLTAAHCLEKTPTVVLGAHSFAKHEDTQQIFRVVRQIAHPCYDETTKEHDLMLLQLNGTAKINKDVRTIKLTKKGDDLKAGTKCHVAGWGITQNRQKKPSDTLREVDVTVIDRKICNDGYNRPIVTMTMVCAGDKKGGKDACVGDSGGPLICNGEQKATVSFGGNQHVVINVNLASILFSQRSISPGYKRRLEATYRWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVJ4</accession>
    <name>A0A670JVJ4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CAMK2B</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670JVJ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029611.1">
        <property type="protein sequence ID" value="ENSPMRP00000027920.1"/>
        <property type="gene ID" value="ENSPMRG00000017756.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158973"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005954">
        <property type="term" value="C:calcium- and calmodulin-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001222">
        <property type="term" value="P:regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14086">
        <property type="entry name" value="STKc_CaMKII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000001">
        <property type="entry name" value="calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="568" mass="63219" checksum="93AE751E4F1F08B5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JX33</accession>
    <name>A0A670JX33_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="4">2.7.7.49</ecNumber>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="4"/>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030794.1">
        <property type="protein sequence ID" value="ENSPMRP00000029026.1"/>
        <property type="gene ID" value="ENSPMRG00000018764.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240511"/>
    <dbReference type="OMA" id="HICHACA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18975">
        <property type="entry name" value="CD_MarY1_POL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RVP_2"/>
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        <property type="entry name" value="RVT_1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Chromo domain-like"/>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0862">Zinc</keyword>
    <keyword evidence="20" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="25">
        <location>
            <begin position="526"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="26">
        <location>
            <begin position="1072"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="23">
        <location>
            <begin position="1373"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1421"/>
            <end position="1559"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="35"/>
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    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="1251"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1524"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
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    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
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    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
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    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
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    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029026.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1559" mass="175494" checksum="9D01FEA6A003CBB6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYJ2</accession>
    <name>A0A670JYJ2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">UNC5D</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the unc-5 family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:cell-cell adhesion via plasma-membrane adhesion molecules"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:pyramidal neuron differentiation"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="TSP1_rpt"/>
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        <property type="entry name" value="TSP1_rpt_sf"/>
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    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
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        <property type="entry name" value="UNC5D_Death"/>
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    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
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        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 14" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
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                <person name="While G.M."/>
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        <scope>IDENTIFICATION</scope>
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</entry>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="4" type="primary">CRABP2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028567052.1">
        <property type="nucleotide sequence ID" value="XM_028711219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K354"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033110.1">
        <property type="protein sequence ID" value="ENSPMRP00000031211.1"/>
        <property type="gene ID" value="ENSPMRG00000020225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587202"/>
    <dbReference type="KEGG" id="pmua:114587202"/>
    <dbReference type="CTD" id="1382"/>
    <dbReference type="GeneTree" id="ENSGT00940000157619"/>
    <dbReference type="OMA" id="TMMADDV"/>
    <dbReference type="OrthoDB" id="195110at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19461">
        <property type="entry name" value="CRABP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="138" mass="15591" checksum="A10B46F605A6C960" modified="2020-06-17" version="1">MPNFSGNWKMKSSENFEELLKALGVNVMLRKIAVAAASKPAVEIKQDGESFYIKTSTTVRTTEISFKIGEEFEEQTVDGRPCKSLAKWESNNKMVCEQRLLKGDGPKTGWSREMTNDGELILTMMADDVVCTRIYVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4F4</accession>
    <name>A0A670K4F4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Teashirt zinc finger homeobox 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TSHZ3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the teashirt C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K4F4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032385.1">
        <property type="protein sequence ID" value="ENSPMRP00000030534.1"/>
        <property type="gene ID" value="ENSPMRG00000019765.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183051"/>
    <dbReference type="OMA" id="VIADDKM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027008">
        <property type="entry name" value="Teashirt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058631">
        <property type="entry name" value="TSHZ1-3_homeodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12487:SF5">
        <property type="entry name" value="TEASHIRT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12487">
        <property type="entry name" value="TEASHIRT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26094">
        <property type="entry name" value="HTH_TSHZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="887"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1039"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="14">
        <location>
            <begin position="889"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="625"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="853"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="644"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="854"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1079" mass="118914" checksum="2E9137E842F7F0A8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5G4</accession>
    <name>A0A670K5G4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Argininosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ASL</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K5G4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033365.1">
        <property type="protein sequence ID" value="ENSPMRP00000031450.1"/>
        <property type="gene ID" value="ENSPMRG00000019854.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183122"/>
    <dbReference type="OMA" id="DFAIEFC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045429">
        <property type="term" value="P:positive regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="3">
        <location>
            <begin position="410"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="515" mass="56393" checksum="2C89A7D47819C62A" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6B6</accession>
    <name>A0A670K6B6_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K6B6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033056.1">
        <property type="protein sequence ID" value="ENSPMRP00000031164.1"/>
        <property type="gene ID" value="ENSPMRG00000020193.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153560"/>
    <dbReference type="OMA" id="VHRRIQI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027681">
        <property type="entry name" value="IRSp53/IRTKS/Pinkbar"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206:SF6">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025503553" description="IMD domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="IMD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="97" mass="10691" checksum="9C4B11B0E1CC8C35" modified="2020-06-17" version="1">MPEGFALFVCFLLPCIQAILDQFNPSLRNFVTMGKNYQKALSGVTVAAKGYFDALVKLGELASDSQGSKELGDTLFQMAEVHRQIQVQLEETVSICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7Y0</accession>
    <name>A0A670K7Y0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 25 member 32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitochondrial FAD transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC25A32</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>FAD(in) = FAD(out)</text>
            <dbReference type="Rhea" id="RHEA:76535"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028592165.1">
        <property type="nucleotide sequence ID" value="XM_028736332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K7Y0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032765.1">
        <property type="protein sequence ID" value="ENSPMRP00000030892.1"/>
        <property type="gene ID" value="ENSPMRG00000020012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600340"/>
    <dbReference type="KEGG" id="pmua:114600340"/>
    <dbReference type="CTD" id="81034"/>
    <dbReference type="GeneTree" id="ENSGT00920000149145"/>
    <dbReference type="OMA" id="TTVWKHE"/>
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        <property type="entry name" value="mitochondrial folate transporter/carrier"/>
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    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
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        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
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    </dbReference>
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        <property type="entry name" value="SOLCAR"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
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            <end position="324"/>
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    <sequence length="332" mass="36957" checksum="029C4086812C3D0B" modified="2020-06-17" version="1">MNPAAAIPGAQSRACTVAGSASTTTTSSAPPARSLFRHVHFENLVAGLSGGVISTLVLHPLDLVKIRFAVSDGLELRPKYNGILHCLTTVWKHEGLRGLYQGVTPNMWGAGASWGLYFFFYNAIKAYKTEDKLESLGPTEHLVSAAEAGAMTLCITNPIWVTKTRLVLQYEAGVDPSKRQYKGMLDALIKIYKYEGVRGLYKGFVPGLFGTSHGALQFMAYEELKSKYNRHRNRRSDLKLSTLEYITMAALSKIFAVSTTYPYQVVRARLQDQHNRYSGLVDVIRRTWRKEGVHGFYKGIIPNVLRVTPACCITFVIYEKVSQLLLNLKNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAR6</accession>
    <name>A0A670KAR6_PODMU</name>
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        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CMC1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
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        <text evidence="1 3">Belongs to the CMC family.</text>
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    </dbReference>
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    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="153" mass="17618" checksum="F9D9AEA8AA40321D" modified="2020-06-17" version="1">MRRESVCLKKKQPPRLRDYDHVVAAAATSVATEVLPSPPLKQGSWYMESAPGAAEEPQLRHVEKDVLIPKMMREKARELCSDKVQAFTKCCQDSGILMVVKCREENAALKECVTGYYNDPSFYEECKAEYLKQREEFRETGNRRKQQRLPTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCA8</accession>
    <name>A0A670KCA8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/arginine repetitive matrix 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SRRM2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028701540.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028701541.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028557375.1">
        <property type="nucleotide sequence ID" value="XM_028701542.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028701543.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000034411.1">
        <property type="protein sequence ID" value="ENSPMRP00000032452.1"/>
        <property type="gene ID" value="ENSPMRG00000021031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581424"/>
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    <dbReference type="GeneTree" id="ENSGT00940000161127"/>
    <dbReference type="OMA" id="QQCIIHY"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:U2-type precatalytic spliceosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:C2H2 zinc finger domain binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
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        <property type="entry name" value="SRRM2_cwf21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF3">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CWF21" evidence="2">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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</entry>
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            <begin position="90"/>
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    <sequence length="156" mass="17725" checksum="54DA9C1B2E5F52E6" modified="2020-06-17" version="1">MPTRFWHLSNPLPVFLVLRLLAAKPDLLPGSEKQIPVLDSTPISPWQDLVKTHLVYAVREEVDLLKDQIQELLEKNGRLQRENHLLKNLASPEQLQNLESRQPLQVRPPCPEDPRARKMRVHQDLEILLPGPSRKTNSHLRSGSSSLNAEPGIPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFP9</accession>
    <name>A0A670KFP9_PODMU</name>
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            <fullName evidence="11">Radial spoke head 10 homolog B</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KFP9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037242.1">
        <property type="protein sequence ID" value="ENSPMRP00000035125.1"/>
        <property type="gene ID" value="ENSPMRG00000022733.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159899"/>
    <dbReference type="OMA" id="YEGDFVC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46613">
        <property type="entry name" value="RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46613:SF1">
        <property type="entry name" value="RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="90973" checksum="9EBA45D60F8E2AFB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KG97</accession>
    <name>A0A670KG97_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MRPL1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028599987.1">
        <property type="nucleotide sequence ID" value="XM_028744154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KG97"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038143.1">
        <property type="protein sequence ID" value="ENSPMRP00000035991.1"/>
        <property type="gene ID" value="ENSPMRG00000023254.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604228"/>
    <dbReference type="CTD" id="65008"/>
    <dbReference type="GeneTree" id="ENSGT00940000162168"/>
    <dbReference type="OMA" id="NVGTLDM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="338" mass="38417" checksum="ABA8B4C99AC0FAC0" modified="2020-06-17" version="1">MRVLVSAQCPSRIFPRIGQHSAVLPSFASLLISNRHYAAKKEKKPRRDAKKKAAESEPKKKKNPYTFPLPSEPKDDVYLTWCYQRPVYEAEVALEMLKTFQQLDFTSPKQHVYIDMTLDMAMEKKKPLEPFVGTVRLPHLFTDDIHKVVVFTADAEQAALARENGATFAGGTELIKPILDGEIKADFYVGVPTMSSKITPLRGMLKQRFPKTRNGSLSYDILQMLQFFKVCHEYEVENGNLIHTPIGMLDMPNDQIVANLDAVIKDVCKYKPLSYGPFVTHLSICSSTSESLDLKVERFLPKRTVKEKAEEKVKEKAEEKVKDDGSDDDEEEERQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGC6</accession>
    <name>A0A670KGC6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KGC6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038183.1">
        <property type="protein sequence ID" value="ENSPMRP00000036031.1"/>
        <property type="gene ID" value="ENSPMRG00000023278.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158067"/>
    <dbReference type="OMA" id="CEPQGRE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052838">
        <property type="entry name" value="Myosin-XVI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47335">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XVI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47335:SF1">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XVI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYOSINHEAVY"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090660">
        <property type="term" value="P:cerebrospinal fluid circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061371">
        <property type="term" value="P:determination of heart left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060287">
        <property type="term" value="P:epithelial cilium movement involved in determination of left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048872">
        <property type="term" value="P:homeostasis of number of cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072520">
        <property type="term" value="P:seminiferous tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033192">
        <property type="entry name" value="ODAD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="155"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="336"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="555" mass="65087" checksum="D7F22A46806784C0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KHW8</accession>
    <name>A0A670KHW8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RAB8A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle membrane</location>
            <topology evidence="13">Lipid-anchor</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670KHW8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038810.1">
        <property type="protein sequence ID" value="ENSPMRP00000036641.1"/>
        <property type="gene ID" value="ENSPMRG00000023613.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157246"/>
    <dbReference type="OMA" id="QIKTHAS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048210">
        <property type="term" value="P:Golgi vesicle fusion to target membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="230" mass="26044" checksum="2E5175C2B85EC751" modified="2020-06-17" version="1">DGAGGHAPRAYRRPRPPLPGLRNMAKTYDYLFKLLLIGDSGVGKTCALFRFSEDAFNATFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFENIRNWVRNIEEHASPDVEKMILGNKCDMNHKRQVSREQGEKLASSFGIKFMETSAKANINIENAFFTLARDIKAKMDKKLEGNSPQGSSQGVKITPELQKKTSFFRCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJ24</accession>
    <name>A0A670KJ24_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TUBGCP4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2. TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner. Gamma-tubulin at the first position is blocked by TUBGCP3 at the last position, allowing 13 protafilaments to grow into a microtubule. The gTuRC (via TUBGCP3 and TUBGCP6) interacts with ACTB and MZT1; the interactions form a luminal bridge that stabilizes the initial structure during complex assembly. The gTuRC (via TUBGCP2) interacts with MZT2A/MZT2B and CDK5RAP2 (via CM1 motif); the interactions play a role in gTuRC activation. Interacts with NINL. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KJ24"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037783.1">
        <property type="protein sequence ID" value="ENSPMRP00000035644.1"/>
        <property type="gene ID" value="ENSPMRG00000023038.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156677"/>
    <dbReference type="OMA" id="QLSMWLL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000001">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="10">
        <location>
            <begin position="415"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="732" mass="82161" checksum="20B0134565967C5C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KL55</accession>
    <name>A0A670KL55_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Receptor-type tyrosine-protein phosphatase sigma</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038808.1">
        <property type="protein sequence ID" value="ENSPMRP00000036639.1"/>
        <property type="gene ID" value="ENSPMRG00000022813.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153617"/>
    <dbReference type="OMA" id="KPHTEYA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd05738">
        <property type="entry name" value="IgI_2_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05739">
        <property type="entry name" value="IgI_3_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000549">
        <property type="entry name" value="Protein tyrosine phosphatase, receptor type S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000027">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000066">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000068">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000015">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000082">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000210">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase delta isoform x2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000098">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase F isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
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        <property type="entry name" value="PTP_cat"/>
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        <property type="entry name" value="Tyr_Pase_dom"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
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    <keyword evidence="12" id="KW-0675">Receptor</keyword>
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    <keyword evidence="6" id="KW-0677">Repeat</keyword>
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    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1254"/>
            <end position="1277"/>
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        <location>
            <begin position="32"/>
            <end position="122"/>
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        <location>
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    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="231"/>
            <end position="313"/>
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            <begin position="320"/>
            <end position="410"/>
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            <begin position="415"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="513"/>
            <end position="604"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
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            <begin position="609"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="711"/>
            <end position="810"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="811"/>
            <end position="908"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="909"/>
            <end position="1005"/>
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        <location>
            <begin position="1009"/>
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    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1344"/>
            <end position="1730"/>
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    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="1648"/>
            <end position="1721"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00079496"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
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    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036639.1"/>
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    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1739" mass="193712" checksum="1D90D4CCCE103E98" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLG8</accession>
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            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
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        <name evidence="10" type="primary">SLC6A8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Na/ntran_symport"/>
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    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="418"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="468"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="505"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="567"/>
            <end position="586"/>
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    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
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    <feature type="binding site" evidence="6">
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="353"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="418"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="421"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
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        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="641" mass="71024" checksum="FCF1A9CFD8994210" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HM85</accession>
    <name>A0A670HM85_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HM85"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000458.1">
        <property type="protein sequence ID" value="ENSPMRP00000000435.1"/>
        <property type="gene ID" value="ENSPMRG00000000323.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000389">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000806">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000824">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF57">
        <property type="entry name" value="ZINC FINGER PROTEIN 154-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="683" mass="77268" checksum="E7085B67F601383C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNX4</accession>
    <name>A0A670HNX4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein OZF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114592597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028576719.1">
        <property type="nucleotide sequence ID" value="XM_028720886.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028576720.1">
        <property type="nucleotide sequence ID" value="XM_028720887.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028576721.1">
        <property type="nucleotide sequence ID" value="XM_028720888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HNX4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001015.1">
        <property type="protein sequence ID" value="ENSPMRP00000000955.1"/>
        <property type="gene ID" value="ENSPMRG00000000715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592597"/>
    <dbReference type="GeneTree" id="ENSGT00940000162179"/>
    <dbReference type="OMA" id="FRNNDYL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001297">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000113">
        <property type="entry name" value="zinc finger protein 699 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="395" mass="44378" checksum="9AD41E1DE87829E7" modified="2020-06-17" version="1">MSSLEREEPILPASGEGERLADDGRNNGNSRETSMLSSEIPAAEEGKEMVADESELKKHREEKSSPSLEVNAHEPQILQEDGQGNSQKICPVCGKIFRYESNLNRHCRSHTGEKPFKCTECGKSLSSSWSLLTHLRTHTGVKPFKCVDCGKSFSESSTLLTHTRTHTGEKPFKCTECGKTFSRNTHLTSHQRTHTGEKPFKCMECGKSYTVSSGLTQHQRTHTGEKPFKCTECGKGFKQPSHLTIHYRTHTGEKPLTCLECGKRFSQLINLTSHQRIHTGDKPFQCMECGKSFTDSSGLAQHQRTHTGEKPFKCTECGKSFQRPSRLTLHYRTHTGEKPFKCMECGKSFSQPGHLTLHQTTHTREKPFECTKCGKRFRKNGSLALHHQTHTAGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP53</accession>
    <name>A0A670HP53_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ohanin/vespryn family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HP53"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001383.1">
        <property type="protein sequence ID" value="ENSPMRP00000001301.1"/>
        <property type="gene ID" value="ENSPMRG00000000976.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234669"/>
    <dbReference type="OMA" id="FTHRIFI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12888">
        <property type="entry name" value="SPRY_PRY_TRIM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="111"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="11"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="300" mass="34055" checksum="2C5F34B3B29E8F6B" modified="2020-06-17" version="1">MKIVEKFRELRQFLEEQEKRLLTHVAEVEKEIAGRRDEELARLSRKLSSLERIIQEMEEKGQQPASELLQDVRRTLQRHEKRESPEKPLAFPPELRNRILESCELNHLVENTMKQWKDALLFSEQIQKANVTLDPDTAHPKLILSEDGKSVRLGDKPQALPDNPERFSDQPCVLGREGFTAGRHFWEVTVGSGGKWVVGVARKSVERKGCFPLSPEWGIWAVGKRGGGYWACTPPDPSPLSLREKPRRIRVTLDYEGGRVSFSDADSGAELYTFSGASFSGETLLPFFDLGGYETHLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQ00</accession>
    <name>A0A670HQ00_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQ00"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001195.1">
        <property type="protein sequence ID" value="ENSPMRP00000001132.1"/>
        <property type="gene ID" value="ENSPMRG00000000829.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="ESHEYAM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000706">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000122">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="KRAB"/>
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        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="227" mass="25948" checksum="80634AE3355F7B3E" modified="2020-06-17" version="1">MPLPKGPIPPLFPWRNQLLDHVSFEEVPVHFTEKEHALLHPGKITVHRKESMAENSGVVASQPNFTRKRSLTIHQRNHTGEKLYNCLECGKGFTQKGHFITHQRSHTGEKPFQCLECGKSFTTHLSTHLRSHTGVKPYTCLECGKSFSVKATLRSHQRSHTGEKPYKCPACGKSFSMLANLRRHERIHAGVKPYKCFECGRSFCKKASLTDHQVSHTKEEQVVYKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQ19</accession>
    <name>A0A670HQ19_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">UV radiation resistance associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">UVRAG</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ). Required for centrosome stability and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Chromosome</location>
            <location evidence="6">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028581719.1">
        <property type="nucleotide sequence ID" value="XM_028725886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HQ19"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001398.1">
        <property type="protein sequence ID" value="ENSPMRP00000001315.1"/>
        <property type="gene ID" value="ENSPMRG00000000985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595554"/>
    <dbReference type="KEGG" id="pmua:114595554"/>
    <dbReference type="CTD" id="7405"/>
    <dbReference type="GeneTree" id="ENSGT00390000012877"/>
    <dbReference type="OMA" id="HVDQNCV"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070418">
        <property type="term" value="C:DNA-dependent protein kinase complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035032">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097680">
        <property type="term" value="P:double-strand break repair via classical nonhomologous end joining"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051684">
        <property type="term" value="P:maintenance of Golgi location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036092">
        <property type="term" value="P:phosphatidylinositol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032801">
        <property type="term" value="P:receptor catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:symbiont entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000148">
        <property type="entry name" value="UV radiation resistance associated gene"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="475"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="682" mass="76697" checksum="64914248080B3FE2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRH7</accession>
    <name>A0A670HRH7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HRH7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002297.1">
        <property type="protein sequence ID" value="ENSPMRP00000002156.1"/>
        <property type="gene ID" value="ENSPMRG00000001575.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005717"/>
    <dbReference type="OMA" id="CCIRTSG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="250" mass="28163" checksum="220F00AD7DE81A87" modified="2020-06-17" version="1">MLKNNLRSTLLKTLRPTTRSSLNILVAGEHLRRRWLNLVSCLQLCAFLVDILALLMCIASTVSVNWRVWRVENIKGIGSGNIWIGIWDVCFWKDPSNNGWYCEDLNEQYPTLPREFFIAQDLMPLASIMNSVALVLLSFALYNVFKPRKHHNFVLTFFSLGALLNLPAGILVLIFVIWNMSAVLQNGEIVFPEAFELPQIPSEQHIGPSIYLGYITAGFQLLSAALVGMERCCIRTSGLRCPSGEEASFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HT97</accession>
    <name>A0A670HT97_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Retinoic acid receptor gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RARG</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028565339.1">
        <property type="nucleotide sequence ID" value="XM_028709506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HT97"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002470.1">
        <property type="protein sequence ID" value="ENSPMRP00000002322.1"/>
        <property type="gene ID" value="ENSPMRG00000001677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586274"/>
    <dbReference type="KEGG" id="pmua:114586274"/>
    <dbReference type="CTD" id="5916"/>
    <dbReference type="GeneTree" id="ENSGT00940000156458"/>
    <dbReference type="OrthoDB" id="6081310at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046965">
        <property type="term" value="F:nuclear retinoid X receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031076">
        <property type="term" value="P:embryonic camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048048">
        <property type="term" value="P:embryonic eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035116">
        <property type="term" value="P:embryonic hindlimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060324">
        <property type="term" value="P:face development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002068">
        <property type="term" value="P:glandular epithelial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003430">
        <property type="term" value="P:growth plate cartilage chondrocyte growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070384">
        <property type="term" value="P:Harderian gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032331">
        <property type="term" value="P:negative regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000647">
        <property type="term" value="P:negative regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045637">
        <property type="term" value="P:regulation of myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048608">
        <property type="term" value="P:reproductive structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048384">
        <property type="term" value="P:retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072089">
        <property type="term" value="P:stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060534">
        <property type="term" value="P:trachea cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06964">
        <property type="entry name" value="NR_DBD_RAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06937">
        <property type="entry name" value="NR_LBD_RAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000001">
        <property type="entry name" value="Retinoic acid receptor beta isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000004">
        <property type="entry name" value="Retinoic acid receptor beta isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047159">
        <property type="entry name" value="NR_DBD_RAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047158">
        <property type="entry name" value="NR_LBD_RAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003078">
        <property type="entry name" value="Retinoic_acid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF7">
        <property type="entry name" value="RETINOIC ACID RECEPTOR GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01292">
        <property type="entry name" value="RETNOICACIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="182"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="454" mass="51205" checksum="640DB3D0155431DD" modified="2020-06-17" version="1">MAGNKERGCSGGTPLAHVNGFPPAVYPFPFPNPHFEVLTNGGYFRSYPNDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCQINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKDVKEEVVVDSYEMTPELEELIQKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTTLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALKIYARRRRPNKPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDELSQPPPLAEPPSSEESPADAKSQEEEEEEEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HU13</accession>
    <name>A0A670HU13_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Coiled-coil domain containing 90B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CCDC90B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HU13"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002920.1">
        <property type="protein sequence ID" value="ENSPMRP00000002730.1"/>
        <property type="gene ID" value="ENSPMRG00000001968.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155453"/>
    <dbReference type="OMA" id="MAYMRFR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000015">
        <property type="entry name" value="Mitochondrial calcium uniporter regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF14">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 90B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="264" mass="29590" checksum="9062D675175C545D" modified="2020-06-17" version="1">MLGFRGRGARLLVRWSNGSSAPQRDFAATAPVKSYDMRRVEITPLEQRKLTFDTHNLVRDLEAHGFGKEQAETIVAALTSLSTLSLDTVYKDMVTQAQQEITLQQLMAHLDSIRKDMVILEKSEFANLRAENEKMKIELDQVKQQLMNETSHIRAENKLDINLERSRVTDMFTDQEKKLMEATTEFHKKDSSTNSSVTEVSNKIDAEIAALKTLMESNKLETIRYLAGAALLVSEAALSQSEGALLRSPSSCRSNVESVNPLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWM2</accession>
    <name>A0A670HWM2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670HWM2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004214.1">
        <property type="protein sequence ID" value="ENSPMRP00000003946.1"/>
        <property type="gene ID" value="ENSPMRG00000002711.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="412" mass="47954" checksum="AABDF174099425E8" modified="2020-06-17" version="1">MLKILQGRLKQYVDRELPEVQAGFRRGRGTRDQIANMRWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTTDWFKIGKGVRQGCILSPCLFNLYAEFIMRKAGLDESQAGIKIAGRNINNLRYADDTTLMAESEEELKNLLMRVKEESTKYGLKLNIKKTKIMATGPITSWQIEGEEMEAVRDFIFLGSMITADGDSSHEIKRRLLLGKKAMANLDKILKSRDITLPTKVRIVKAMVFPVVMYGSESWTIKKADRRRIDAFELWCWRRLLRVPWTARRSNASILKEIRPECSLEGQILKLRLQYFGHLMRREDSLEKTLMLGKMEGTRRRGRQRMRWLDSVLKATNMSLTKLREAVEDRSAWRALVHGVTKSRTRLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HYN1</accession>
    <name>A0A670HYN1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome 6 open reading frame 58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">C6orf58</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LEG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HYN1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005121.1">
        <property type="protein sequence ID" value="ENSPMRP00000004804.1"/>
        <property type="gene ID" value="ENSPMRG00000003303.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004904"/>
    <dbReference type="OMA" id="PKLMDDW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008499">
        <property type="entry name" value="Leg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18820">
        <property type="entry name" value="LEG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18820:SF1">
        <property type="entry name" value="PROTEIN LEG1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05612">
        <property type="entry name" value="Leg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025609790" evidence="6">
        <location>
            <begin position="30"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="358" mass="40361" checksum="C89E6AD175DA2828" modified="2020-06-17" version="1">MVLSSMGCLFLRIFFWHLFIFLFATSSLSLELTEKLAEEPESYSDAVPPLWHSAPGNLDEYPVNGNNILINPWSYPQRLGLYKILLKATSNFFTPPGPNDADSNVPGRLPQQHGVQYISNKNILWGLALQHGWQYSTGRLEDPTNITRCGKKDGDNLCISERSWWACMNYYLAIVPFLGALESGIFGDLADKVEILPPDEKRADFCHSVAECNAQAPKAMAGWRDFFKYLSSTALSSEVPEAQEAALNYMWKAHVHSLAYGRRKFKNRLPYLSGPESNFGEDWAATVDFIAATHFHTDQETTNRLQTGLPPRMLLEGEKAPFIADFTPEQNKVLFLLGALSRTNEKTGRRLDNHTVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZL3</accession>
    <name>A0A670HZL3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SPARC related modular calcium binding 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SMOC1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HZL3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005468.1">
        <property type="protein sequence ID" value="ENSPMRP00000005134.1"/>
        <property type="gene ID" value="ENSPMRG00000003523.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000005478.1">
        <property type="protein sequence ID" value="ENSPMRP00000005140.1"/>
        <property type="gene ID" value="ENSPMRG00000003523.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018436"/>
    <dbReference type="OMA" id="GERDNHC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060173">
        <property type="term" value="P:limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045667">
        <property type="term" value="P:regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000076">
        <property type="entry name" value="SPARC-related modular calcium binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000012">
        <property type="entry name" value="SPARC-related modular calcium binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000004">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000003">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF13">
        <property type="entry name" value="SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16597">
        <property type="entry name" value="Thyroglob_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044625031" evidence="13">
        <location>
            <begin position="31"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="15">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="14">
        <location>
            <begin position="98"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="14">
        <location>
            <begin position="230"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="268"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="459" mass="50648" checksum="4A0E1D9F16952AD0" modified="2020-06-17" version="1">MPARRWGSGAPRLLLALLLLLLAVVPRASAHRATGPRFLISDRDRDPQCNLHCSRSPTKPLCASDGRTYESMCDYQRAKCRDASLSVVHRGRCKDAGQSKCRIERAQALDQAKKPQEAVFIPECTEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDRPLGQGNSGRKDDGSKPTPTMETQPVFDGEEITAPTLWIKHLVIKDSKLNSSSMKNSEKVNSCDHERQSALEEARQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDTGRPLPGTSTRYETPVCESDARSKSPETDDPFKDRELPGCPEGKKVEFITSLLDALTTDMVQAINSAAPAGGGRFSEPDPSHTLEERVVHWYFSQLDNNNSNDINKREMKPFKRYVKKKAKPKKCTRRFIDYCDLNKDKSISLQELKGCLGVGKEGGSVGSFPHGKRQGVNPFIGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZN7</accession>
    <name>A0A670HZN7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAX interactor 1, dimerization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MXI1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028586153.1">
        <property type="nucleotide sequence ID" value="XM_028730320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HZN7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005385.1">
        <property type="protein sequence ID" value="ENSPMRP00000005056.1"/>
        <property type="gene ID" value="ENSPMRG00000003471.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597494"/>
    <dbReference type="KEGG" id="pmua:114597494"/>
    <dbReference type="CTD" id="4601"/>
    <dbReference type="GeneTree" id="ENSGT00940000155809"/>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18930">
        <property type="entry name" value="bHLHzip_MXI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000014">
        <property type="entry name" value="Max dimerization protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF13">
        <property type="entry name" value="MAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="286" mass="32202" checksum="8415020494C626D6" modified="2020-06-17" version="1">MGKRGRPRKEFKCEEDAVEPGVGQPRQQQQLPVADNMSRCPFSDIFNTSSEDSMEKINTFLQNVQILLEAASYLEQIEKENKKCEHGYASTFPSMPSLGLQDPKPPQRLSRARKHSSGGSSTGTANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCSRHTTLGLLNKAKAHIKKLEEADRRSQHQLDNLEREQRFLKRRLEQLQGSQEIERIRMDSTGSTISSDRSDSEREEIEVDVESTEFSHGDVDDISTTSTSDIDDHSSLQSIGSDEGYSSASVKLSFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0V6</accession>
    <name>A0A670I0V6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NEK3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670I0V6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005840.1">
        <property type="protein sequence ID" value="ENSPMRP00000005486.1"/>
        <property type="gene ID" value="ENSPMRG00000003742.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159738"/>
    <dbReference type="OMA" id="YSYELQY"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000172">
        <property type="entry name" value="serine/threonine-protein kinase Nek1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44984">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44984:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
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    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
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        <location>
            <begin position="4"/>
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            <begin position="400"/>
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            <begin position="426"/>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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            <dbReference type="ARBA" id="ARBA00001946"/>
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            <dbReference type="RuleBase" id="RU000304"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005486.1"/>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="454" mass="51821" checksum="DD8FA42C4A029206" modified="2020-06-17" version="1">MEKYSVLAILGEGSFGRVLLVCHKNKNQKYAMKEIRLPKSVFGAEKSWNESILLAKMKHPNIVAYLESFEDDGHLYIVMEYCDDGDLMQKIKLQKGKLFPEDTILNWFAQICLGLKYIHDKRVLHRDIKSKNIFLTQNGKVKLGDFGSALLLSSPEAYACSYVGTPYYVPPEIWENTPYNNKSDIWSLGCILYELCTLKHPFQANSWKHLILKICKGYYNPLPSHYTYELQYLIKQMFKKNPKNRPSATTILARSCLAKCIRNLASAEEQAKHARSKSCDSETEAMAKGFCEMGLEKAGKDETSPEAVLPNPHRQQWEKGRSSSVIKILGNASLLTSSITTKEDTSGDVRRYDENVTRKQWTKEPPETLMNILRNADVSLAFKTYTICKGGSDDLLRGPLTEDIKTSDEPDGEIIMEDAERLEPRSDDEDTDFEADDDPDWVFELKRMTKMESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I2M0</accession>
    <name>A0A670I2M0_PODMU</name>
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        <recommendedName>
            <fullName evidence="8">Leiomodin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LMOD1</name>
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    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for proper contractility of visceral smooth muscle cells. Mediates nucleation of actin filaments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
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        </subcellularLocation>
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    <dbReference type="AlphaFoldDB" id="A0A670I2M0"/>
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        <property type="gene ID" value="ENSPMRG00000003852.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:muscle contraction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:pointed-end actin filament capping"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TMOD"/>
    </dbReference>
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        <property type="entry name" value="LEIOMODIN-1"/>
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    </dbReference>
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        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="80"/>
            <end position="322"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="80"/>
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        </location>
    </feature>
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        </location>
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        </location>
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            <end position="224"/>
        </location>
    </feature>
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            <end position="248"/>
        </location>
    </feature>
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            <end position="306"/>
        </location>
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        </location>
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        </location>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070932"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="637" mass="70004" checksum="4692577E17494902" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I339</accession>
    <name>A0A670I339_PODMU</name>
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        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase TRIM8</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Glioblastoma-expressed RING finger protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING finger protein 27</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">RING-type E3 ubiquitin transferase TRIM8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Tripartite motif-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">TRIM8</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Also modulates STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box. Interacts with HSP90AB1; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1. Interacts with MAP3K7/TAK1. Interacts with PIAS3. Interacts with TICAM1. Interacts with TRIM15; this interaction prevents TRIM8 cytoplasmic translocation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRIM/RBCC family.</text>
    </comment>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
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        <property type="term" value="P:host-mediated suppression of symbiont invasion"/>
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        <property type="term" value="P:stem cell population maintenance"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="Znf-RING_euk"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
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        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 21" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="15"/>
            <end position="56"/>
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        <location>
            <begin position="430"/>
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    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="186"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="23">
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            <begin position="439"/>
            <end position="454"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="26">
        <source>
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        </source>
    </evidence>
    <sequence length="551" mass="62206" checksum="04CBDFF6C0BB194E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3L6</accession>
    <name>A0A670I3L6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Insulin receptor substrate 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.29.30">
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="IRS-type PTB" evidence="5">
        <location>
            <begin position="153"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38834" checksum="A032044927902C83" modified="2020-06-17" version="1">PTPAGEGRSLARRGFVQQQQPPPPPGVRKCGYLRKHKHGHRRFFVLRAPARLEYYESEKKWRSKSAAPKRSIALDSCLNIHKRADAKHKHLVALYTRDEYFALAAESEPEQEAWYVALTELLRESQPAGHDSPRRQPPSASREEPPLPGASPYREVWQVTLKPRGLGQSRNLAGVHRLCLAARTVGLVRLNCQRPCVTLQLMNIRRCGHSDSFFFMELGRSASTGPGELWMQADDSVVAQNIHETILEAMKALRELAEFRPRSKSHTLPAAAPPAPLAILLASWPLRSWVQPWTLQQLVTTATHLRLLLTCSWMATLPWSGDTFVVGPTYGRALEETRFPGSALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I616</accession>
    <name>A0A670I616_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SLC6A6</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70687"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70688"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-alanine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71247"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71248"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hypotaurine(out) + chloride(out) + 2 Na(+)(out) = hypotaurine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71243"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71244"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>taurine(out) + chloride(out) + 2 Na(+)(out) = taurine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71223"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71224"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I616"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007687.1">
        <property type="protein sequence ID" value="ENSPMRP00000007180.1"/>
        <property type="gene ID" value="ENSPMRG00000004867.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154583"/>
    <dbReference type="OMA" id="WAHCNHT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022858">
        <property type="term" value="F:alanine transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005369">
        <property type="term" value="F:taurine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11510">
        <property type="entry name" value="SLC6sbd_TauT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002434">
        <property type="entry name" value="Na/ntran_symport_taurine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF141">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01200">
        <property type="entry name" value="TAUTRANSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 17" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="327"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="424"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="427"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="428"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033998"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="646" mass="72522" checksum="6A53687F24B35F61" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6P6</accession>
    <name>A0A670I6P6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Synaptojanin-1</fullName>
            <ecNumber evidence="5">3.1.3.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SYNJ1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.36"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with ASH/GRB2. Interacts with PACSIN1, PACSIN2 and PACSIN3. Interacts with AMPH, SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain). Interacts with BIN1 and DNM1. Interacts with EPS15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007855.1">
        <property type="protein sequence ID" value="ENSPMRP00000007339.1"/>
        <property type="gene ID" value="ENSPMRG00000004826.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157964"/>
    <dbReference type="OMA" id="FERHMSM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007612">
        <property type="term" value="P:learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904980">
        <property type="term" value="P:positive regulation of endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12719">
        <property type="entry name" value="RRM_SYNJ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000076">
        <property type="entry name" value="Synaptojanin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000003">
        <property type="entry name" value="Synaptojanin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015047">
        <property type="entry name" value="SYNJ1/2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034971">
        <property type="entry name" value="SYNJ1_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF158">
        <property type="entry name" value="SYNAPTOJANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08952">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01165">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 17" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAC" evidence="20">
        <location>
            <begin position="139"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="936"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1054"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1482"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1113"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1128"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1226"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1486"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1499"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1523" mass="168987" checksum="B1CFAF9624F4A39C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8N1</accession>
    <name>A0A670I8N1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin-10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CDH10</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Cell membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028593756.1">
        <property type="nucleotide sequence ID" value="XM_028737923.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593758.1">
        <property type="nucleotide sequence ID" value="XM_028737925.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593759.1">
        <property type="nucleotide sequence ID" value="XM_028737926.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593760.1">
        <property type="nucleotide sequence ID" value="XM_028737927.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593761.1">
        <property type="nucleotide sequence ID" value="XM_028737928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I8N1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008735.1">
        <property type="protein sequence ID" value="ENSPMRP00000008170.1"/>
        <property type="gene ID" value="ENSPMRG00000005531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600996"/>
    <dbReference type="KEGG" id="pmua:114600996"/>
    <dbReference type="CTD" id="1008"/>
    <dbReference type="GeneTree" id="ENSGT00940000154187"/>
    <dbReference type="OMA" id="CSPEITF"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="245" mass="27567" checksum="A27C517C9A028D33" modified="2020-06-17" version="1">MEATCLVVLLRLCVILAFPVYLLWYLGIWESLCKKLFPYCMSVASSCYNKCMSDKKREMFSNLKDFASPTGALTLLEIGAGTGSNFQFYPAGCKIICTDPNPNFQKFYNKSLAENPHVQVERCLVAPAEDLHQVPAASVDVVVSTLVLCSVKSPEQVMKEVLRVLRPGGAYYFLEHVAGAPSSWTLFWQQICDPTWICLFDGCHLARENWNVLEKAGFSELKLRHIDAPIKWPPIRPHIIGYAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IB70</accession>
    <name>A0A670IB70_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratin 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KRT18</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IB70"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009758.1">
        <property type="protein sequence ID" value="ENSPMRP00000009140.1"/>
        <property type="gene ID" value="ENSPMRG00000006141.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153309"/>
    <dbReference type="OMA" id="KIRTDIQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF349">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="2" id="KW-0416">Keratin</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="136"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="352"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="516" mass="57006" checksum="6602436A2156D927" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBC9</accession>
    <name>A0A670IBC9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IBC9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009548.1">
        <property type="protein sequence ID" value="ENSPMRP00000008937.1"/>
        <property type="gene ID" value="ENSPMRG00000006007.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286962"/>
    <dbReference type="OMA" id="TELEWFS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="445" mass="49688" checksum="F16581342E490497" modified="2020-06-17" version="1">MANYRPVSNLPFLGKVIERAVAEQLQARLEEADHLDPFQSGFRPHHGTETALVALVDDLRRARDKGKSCFLVLLDLSAAFDTIDHSILLDRLEGLGAGGTVIQWFRSFLLGRVQKVVVGDECSDPWALTCGVPQGSVLSPMLFNIYMQPLGEIIRRFGLGVHQYADDTQLYLSFKSEPVKAVKVLRECLEAVGGWMAANRLRLNPDKTEVLFLGDRRRAGVEDSLVLNGVTVPLKDQVRSLGVILDSQLSMEAQVKSVSRAAVYQLHLVRRLRPYLPADCLARVVHALVISRLDYCNALYVGLPLKVTRKLQLIQNAAARLVTGGGRRDHITPVLKDLHWLPVRFRAQFKVLVLTFKALNGLGPVYLKERLHPHHSARTLRSSAEGLLAVPSLREAKLQGTRQRAFSVVAPALWNALPADVKAINNYLTFRRHLKAALFREVFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IC83</accession>
    <name>A0A670IC83_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="16">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TRMT1L</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>guanosine(27) in tRNA(Tyr) + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(27) in tRNA(Tyr) + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:83895"/>
            <dbReference type="Rhea" id="RHEA-COMP:20240"/>
            <dbReference type="Rhea" id="RHEA-COMP:20241"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:83896"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A670IC83"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009919.1">
        <property type="protein sequence ID" value="ENSPMRP00000009293.1"/>
        <property type="gene ID" value="ENSPMRG00000006250.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063646"/>
    <dbReference type="OMA" id="CICHLSC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160248">
        <property type="term" value="F:tRNA (guanine(27)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000098">
        <property type="entry name" value="Trmt1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF1">
        <property type="entry name" value="TRMT1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 16" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="448" mass="50538" checksum="91ACF3BC2C7EC271" modified="2020-06-17" version="1">PLECLDAFGATGIMGLQWAKHLGNSVKVTINDYNENSVRMIQENCHLNKMKVVMNFKEEEDCDETIEEGEENLPAIEVTKMDANVIMHLRAFDFIHLDPFGSSVNYLDAAFRNVRNLGIVSVTSTDISSLYSKAQHVAQRHYGCNIVRTEYFKELAARMVVAAVARAAARCNKGIEVLLAVALEHFVLVEVRVLRGPSPADDTVKKIRYLLHCQWCEERVFKKDGNMIEENPYRQLPCDCHSRMTGKTAVELGPLWSGSLFNTGFLRRMLFEAVQYGLEDIQTLLKTLICEAECTILKQFSIHGPTSQNKQEECGVFIKTPDTAADYYVVHGKRKNNENNQNGTKRQKSESNAEHPAFYYNIHRHSIKGMNMPKLNKFLHYLSQAGYRVSRTHFDPMGVRTNVPLAQFKSILVKYSTPTYMGAQSEGSLQASDESQVGADGDFAEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEV5</accession>
    <name>A0A670IEV5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histamine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HNMT</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IEV5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011160.1">
        <property type="protein sequence ID" value="ENSPMRP00000010465.1"/>
        <property type="gene ID" value="ENSPMRG00000006961.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002862"/>
    <dbReference type="OMA" id="IDNDERY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046539">
        <property type="term" value="F:histamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001695">
        <property type="term" value="P:histamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016673">
        <property type="entry name" value="HHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51597">
        <property type="entry name" value="SAM_HNMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="175" mass="19884" checksum="D72207D51E16D5AC" modified="2020-06-17" version="1">MTMRSLLSDHSHYVESFRLFLENSTEHQCMLEFIQKKLPGILSSIGSGKSTINILSVGGGAGEVDLQILAEVRAKYPGVVICNDVVEPSAEQISAYKERVAKTENLENIKFSWHKETSLEYESRMKASKEVKKWNFIHMIQMLYYVKDIPATIRFFHSLLEPGAKLLIILVSGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IF15</accession>
    <name>A0A670IF15_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MGAT5</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028600552.1">
        <property type="nucleotide sequence ID" value="XM_028744719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IF15"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010699.1">
        <property type="protein sequence ID" value="ENSPMRP00000010042.1"/>
        <property type="gene ID" value="ENSPMRG00000006713.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604540"/>
    <dbReference type="KEGG" id="pmua:114604540"/>
    <dbReference type="CTD" id="4249"/>
    <dbReference type="GeneTree" id="ENSGT00940000153470"/>
    <dbReference type="OMA" id="HCESKLK"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027833">
        <property type="entry name" value="MGT5A-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15027">
        <property type="entry name" value="MGT5A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MGT5A-like N-terminal" evidence="18">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="17">
        <location>
            <begin position="173"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF15027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="742" mass="84521" checksum="C033FAA0BF147FCC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFP4</accession>
    <name>A0A670IFP4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aldehyde dehydrogenase 9 family member A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ALDH9A1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-(trimethylamino)butanal + NAD(+) + H2O = 4-(trimethylamino)butanoate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17985"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16244"/>
            <dbReference type="ChEBI" id="CHEBI:18020"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IFP4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011537.1">
        <property type="protein sequence ID" value="ENSPMRP00000010815.1"/>
        <property type="gene ID" value="ENSPMRG00000007174.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163309"/>
    <dbReference type="OMA" id="CREGIRM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047105">
        <property type="term" value="F:4-trimethylammoniobutyraldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019145">
        <property type="term" value="F:aminobutyraldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018467">
        <property type="term" value="F:formaldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07090">
        <property type="entry name" value="ALDH_F9_TMBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000019">
        <property type="entry name" value="4-trimethylaminobutyraldehyde dehydrogenase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000016">
        <property type="entry name" value="4-trimethylaminobutyraldehyde dehydrogenase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="128"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="594" mass="65010" checksum="3936EB0A909B1082" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGH5</accession>
    <name>A0A670IGH5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SUN domain-containing ossification factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Membrane protein CH1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">SUN-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SUCO</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Rough endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IGH5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011917.1">
        <property type="protein sequence ID" value="ENSPMRP00000011155.1"/>
        <property type="gene ID" value="ENSPMRG00000007446.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013502"/>
    <dbReference type="OMA" id="HTHTEMD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
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    <sequence length="1160" mass="129192" checksum="7BC2EE9C15910C51" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIK6</accession>
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        <name evidence="7" type="primary">SH2B3</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="589" mass="65860" checksum="C6837E8AAA614FC8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIQ0</accession>
    <name>A0A670IIQ0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 7 member 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC7A14</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587395.1">
        <property type="nucleotide sequence ID" value="XM_028731562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IIQ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012319.1">
        <property type="protein sequence ID" value="ENSPMRP00000011534.1"/>
        <property type="gene ID" value="ENSPMRG00000007724.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597975"/>
    <dbReference type="KEGG" id="pmua:114597975"/>
    <dbReference type="CTD" id="57709"/>
    <dbReference type="GeneTree" id="ENSGT00940000155893"/>
    <dbReference type="OMA" id="GFVMYFY"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015185">
        <property type="term" value="F:gamma-aminobutyric acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051939">
        <property type="term" value="P:gamma-aminobutyric acid import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000024">
        <property type="entry name" value="High affinity cationic amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF17">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="11">
        <location>
            <begin position="627"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="716"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="770" mass="84435" checksum="38CB02C837BC15FC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJZ8</accession>
    <name>A0A670IJZ8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Outer dense fiber of sperm tails 2 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ODF2L</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ODF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IJZ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012758.1">
        <property type="protein sequence ID" value="ENSPMRP00000011946.1"/>
        <property type="gene ID" value="ENSPMRG00000007971.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063497"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026099">
        <property type="entry name" value="Odf2-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23162">
        <property type="entry name" value="OUTER DENSE FIBER OF SPERM TAILS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23162:SF7">
        <property type="entry name" value="PROTEIN BCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="305"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="407"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="539"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="698" mass="79922" checksum="52A6F6F27B29F220" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IK63</accession>
    <name>A0A670IK63_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Serine/threonine-protein kinase H1</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Protein serine kinase H1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">PSKH1</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028595551.1">
        <property type="nucleotide sequence ID" value="XM_028739718.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028595553.1">
        <property type="nucleotide sequence ID" value="XM_028739720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IK63"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012776.1">
        <property type="protein sequence ID" value="ENSPMRP00000011964.1"/>
        <property type="gene ID" value="ENSPMRG00000007996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602011"/>
    <dbReference type="KEGG" id="pmua:114602011"/>
    <dbReference type="CTD" id="5681"/>
    <dbReference type="GeneTree" id="ENSGT00940000157041"/>
    <dbReference type="OMA" id="SYAGEHW"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14087">
        <property type="entry name" value="STKc_PSKH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000416">
        <property type="entry name" value="Serine/threonine-protein kinase H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 27 28" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="22" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="24" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0519">Myristate</keyword>
    <keyword evidence="15 27 28" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 28" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="30">
        <location>
            <begin position="86"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="412" mass="47134" checksum="199CD7F8DFC349CB" modified="2020-06-17" version="1">MGCGTSKVLPEPPKDVHLDLVKKVEPYTGYKTDIYKHFIKGDGDAIKSAIPSPPRHTNPHVEQAEPRKNRVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHKATKQPYAIKLIETKYREGREVCESELCVLRRVRHTNIIQLIEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVKYLHTLGITHRDLKPENLLYYHPGMDSKIMITDFGLASARKKGDDCLMKTTCGTPEYIAPEILVRKPYTNSVDMWALGVISYILLSGTMPFEDDNRTRLYRQILKGKYSYSGEPWPSVSNLAKDFIDRLLTVDPSDRMTALQALKHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTKSNKSRRVRERELRELNLRYQQQYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKA3</accession>
    <name>A0A670IKA3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IKA3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012512.1">
        <property type="protein sequence ID" value="ENSPMRP00000011712.1"/>
        <property type="gene ID" value="ENSPMRG00000007843.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="PLASTWM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="889" mass="105024" checksum="D8742C8C63F2A754" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILF2</accession>
    <name>A0A670ILF2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short transient receptor potential channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TRPC1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587041.1">
        <property type="nucleotide sequence ID" value="XM_028731208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ILF2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013389.1">
        <property type="protein sequence ID" value="ENSPMRP00000012536.1"/>
        <property type="gene ID" value="ENSPMRG00000008398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597841"/>
    <dbReference type="CTD" id="7220"/>
    <dbReference type="GeneTree" id="ENSGT01060000248594"/>
    <dbReference type="OMA" id="SRPTIVX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051281">
        <property type="term" value="P:positive regulation of release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051592">
        <property type="term" value="P:response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000088">
        <property type="entry name" value="short transient receptor potential channel 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000266">
        <property type="entry name" value="Transient receptor potential cation channel subfamily c member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005457">
        <property type="entry name" value="TRPC1_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF56">
        <property type="entry name" value="SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01642">
        <property type="entry name" value="TRPCHANNEL1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="19">
        <location>
            <begin position="181"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="781" mass="90210" checksum="19F4AF5B27C56756" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INF7</accession>
    <name>A0A670INF7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocyte differentiation antigen CD14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Myeloid cell-specific leucine-rich glycoprotein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670INF7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014052.1">
        <property type="protein sequence ID" value="ENSPMRP00000013166.1"/>
        <property type="gene ID" value="ENSPMRG00000008810.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005689"/>
    <dbReference type="OMA" id="SSSCQWP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046696">
        <property type="term" value="C:lipopolysaccharide receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016337">
        <property type="entry name" value="Monocyte_diff_Ag_CD14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10630">
        <property type="entry name" value="MONOCYTE DIFFERENTIATION ANTIGEN CD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10630:SF3">
        <property type="entry name" value="MONOCYTE DIFFERENTIATION ANTIGEN CD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="18" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="8" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 21" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025579025" description="Monocyte differentiation antigen CD14" evidence="21">
        <location>
            <begin position="22"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="445" mass="49957" checksum="CE302E7195F9B039" modified="2020-06-17" version="1">QGGAAFVFSLLLGLELPKAKANCNFTESQRHCVCSLEANNFIQCLPATTYELRGGNLEQFAGSSGIKPNPQIIEILEALLVRKLIFTDLIVPEVLVPGSLQFLSYTQVSELEFVNCTFLRATHWSLQGWWDLKVSSLRFHKVTAAPLDDRLNMSRLRRWLETLQNLTVTESQVTSVPCEISKMFTSLHLLDVSGNSFQDQTMKSTFCEGVFPQLQILKLHHNNLTSFETVCKTLGHLKMLTHLDLSQNNFQPRVFSSSCRWPHSLQIFNLSSTGLEQIGSSLPPNIEILDLSANNIFTLDFSLPALKELYLSKNRLQTVPSLDRLPSLQVLSLDQNQISQLPSNHLLRLQSLKAGHNLYNCSCSRDIQDLAAKPSLLPDWPQDYTCHSPLNYQGSLVKNAHFSSLQCKALVTRGSIFNLLICLHLNLFLTWGRGRCTGTVSLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQ78</accession>
    <name>A0A670IQ78_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gypsy retrotransposon integrase-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IQ78"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015270.1">
        <property type="protein sequence ID" value="ENSPMRP00000014298.1"/>
        <property type="gene ID" value="ENSPMRG00000009529.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166838"/>
    <dbReference type="OMA" id="WPRRDEI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="184"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="382" mass="42290" checksum="6E6B159A44D380E1" modified="2020-06-17" version="1">MLRWTVFLAAYHYRLIHRPGKSMGHADALSRCPLPAFVEDPAPASSLLLIEDLPAAPVSAATVASASAQDRTISRVLNWVWRGWPQGPFASEFQPFATRQHELSAHRGYLLWGDRVVIPQGLRQRVLEALHVGHPGIVKMKALARCYVWWPNMDDAITAWVSACQACQESRPAPPAAKGHTWETPKTPWSRVHIDLAGPFHGRTFMVVVDAYSKWLEVALMPSTTTKAVIRVLRGLFATHGCPDVLVSDNGPQFTSGTFERYLLGLGIHHALTAPFHPSSNGQAERMVRSTKEALARLDRGDWHEQVAEYLFVQHITPHAATGRSPAELLMGRRLRSPLDRLHPDFAVAEPPGCANAPRSFVPGNQVFARNYVGDILGCQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IS25</accession>
    <name>A0A670IS25_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IS25"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015937.1">
        <property type="protein sequence ID" value="ENSPMRP00000014923.1"/>
        <property type="gene ID" value="ENSPMRG00000009955.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162286"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="337" mass="38782" checksum="92F896D3F14EBE8A" modified="2020-06-17" version="1">MGLKGKPKLGLLHSCSQPLRQGEVVRTLYAALWGWGGKKIFFLISPPKNWVRPMVRCALWCEKYGSSSDPNQTQVNRAHSFIMRLRLHSDMGLCYFEEMEAVRDFTFLGSMITADGDSSHEIKRRLLLGRRAMTGLDSILRSRDVTLPTKVRIVKTMVFPVVMYGSESWTIKKADCRRIDAFELWCWRRLLRVPWTARRSNLYILKEISPECSLEGQIVKLRLQYFVHLVRREDSLEKTLMLGKMEGTRRRGTTEDEMVGQCSRSYQHESDQTAGGSGRQECLVCSGPWGHKELDTTERLNNNNNNTSTSIPISNTPLTPQYLLQYGTMGCFFYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITJ9</accession>
    <name>A0A670ITJ9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized LOC114599074</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114599074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028589466.1">
        <property type="nucleotide sequence ID" value="XM_028733633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ITJ9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015498.1">
        <property type="protein sequence ID" value="ENSPMRP00000014507.1"/>
        <property type="gene ID" value="ENSPMRG00000009673.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599074"/>
    <dbReference type="KEGG" id="pmua:114599074"/>
    <dbReference type="GeneTree" id="ENSGT00940000164586"/>
    <dbReference type="OMA" id="CCLNFTG"/>
    <dbReference type="OrthoDB" id="6363818at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025630436" evidence="5">
        <location>
            <begin position="29"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="419" mass="46310" checksum="FA1F361AED1575DE" modified="2020-06-17" version="1">MGRDGAGQKRWTLILFGVVLLSRELVLGALEETCNCSAEVDFQGLQTKLAPEMCCLNLTRTKINSLDWSIFTGTAGLRELYLSNCGISDIINAENGSSTLEILHLDHNQLSLLPDGFLRNAPSLRVIHLESNQLQKLPESFLKASDQIQEIHLAFNNLSSLPSGIFKPSLLTLGLSNNSWHCTCSLLEDLEKCLPAPLNVEVACSTPERYHGMNLRDIPKQEVCRNHSLTALFVCLPVVAILVLVTWCFCKRQKKTSYHPHAGKECRLATVERNGSKEPGDHHCYIPCELPMASAAESEKNILLRNQVLLKPSAALLGSSRDLYEEVEIKLGASDDSLVKANGESLEQDKSGSKKPTVAEEGYTGGESEAETVSVTDVLKDSADREKLYMNQSVDYYNLVPGIELEDSDHMEYENIDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IU20</accession>
    <name>A0A670IU20_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114593705</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028578166.1">
        <property type="nucleotide sequence ID" value="XM_028722333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IU20"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016480.1">
        <property type="protein sequence ID" value="ENSPMRP00000015430.1"/>
        <property type="gene ID" value="ENSPMRG00000010287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593705"/>
    <dbReference type="KEGG" id="pmua:114593705"/>
    <dbReference type="GeneTree" id="ENSGT00940000162520"/>
    <dbReference type="OMA" id="WVSARYT"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF340">
        <property type="entry name" value="AROMATIC-PREFERRING AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="484" mass="52704" checksum="F238B87C2909AAEB" modified="2020-06-17" version="1">MGKGRPSRPGSANPQPSTATERLKLKREIGLASAVSLIAGTMIGSGIFMSPEWVLRNIGSLAGSLIIWASCGILSTFGALSYAELGTLIKESGGEYIYILRTFGSLPAFLFAFTSVIVVRPAGVAAISLSFAEYTVAAFHPGCPSPQVAIKCAAVACILLLTLINCLSVRLATSVMNVFTVAKLLALLVIVVGGVVLLVQGETHRFQNGFQNTRLEAGVIGIAFYQGLWSFDGWNNLNYVTEEIKKPEVNLPRAMMIAIPLVTCFYLLVNVSYFAAMAPAELLSSGAVAITWGNKVLGSWVWLMSLSVAMSSFGSANGTFFSGGRMCYIAAREGHMPDILSMAHIRYLTPSPALIFTSAVSIIMVIAGSFSQIVNLFSFTAWLFYGITVAGLLYLKIKKPELPRSYKVPIIIPVVFLMASIYLVLAPIIDQPQMEFLYVILFISSGVIFYFPLIHYKYHPTFLRKFTMHFQLFLEVAPTEKNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IU87</accession>
    <name>A0A670IU87_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA binding motif protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RBM24</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <location>
            <begin position="852"/>
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    </feature>
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            <begin position="937"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015177.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1166" mass="131716" checksum="653ABC76A7DF4BBB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWL5</accession>
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        <name evidence="24" type="primary">NTNG1</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="14">Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.</text>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
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            <topology evidence="1">GPI-anchor</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="nucleotide sequence ID" value="XM_028732631.1"/>
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        <property type="nucleotide sequence ID" value="XM_028732632.1"/>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="signal peptide" evidence="20">
        <location>
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            <end position="26"/>
        </location>
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    <feature type="chain" id="PRO_5025522247" description="Netrin-G1" evidence="20">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
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            <begin position="518"/>
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        <location>
            <begin position="46"/>
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        <location>
            <begin position="419"/>
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    <feature type="domain" description="EGF-like" evidence="21">
        <location>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
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            <end position="448"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055052"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068897"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079150"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50027"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51117"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016186.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="541" mass="61119" checksum="CE4FA2A59D6330F6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWZ3</accession>
    <name>A0A670IWZ3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vitelline membrane outer layer 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IWZ3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017579.1">
        <property type="protein sequence ID" value="ENSPMRP00000016480.1"/>
        <property type="gene ID" value="ENSPMRG00000010995.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009313"/>
    <dbReference type="OMA" id="NDMRVFC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.20">
        <property type="entry name" value="Vitelline membrane outer layer protein I (VOMI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005515">
        <property type="entry name" value="VOMI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036706">
        <property type="entry name" value="VOMI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841:SF2">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER PROTEIN I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03762">
        <property type="entry name" value="VOMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51092">
        <property type="entry name" value="Vitelline membrane outer protein-I (VMO-I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15709" checksum="2347C94BF3489B21" modified="2020-06-17" version="1">FLPDKFFNNHSKKQRPNQGGGVKDDDTALNGIRLHCTDSSVIESATGPWGSWTGIHYCPQSNLISFSLRVEAPRGKGDDTAANNIQFTCQDGTGLMGQGLTWGNFGAWSNRCSSGYICGIQTKVEGLQGLSDDTALNDVHLYCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXK6</accession>
    <name>A0A670IXK6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP-type and C3HC4-type zinc finger-containing protein 1</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670IXK6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017006.1">
        <property type="protein sequence ID" value="ENSPMRP00000015927.1"/>
        <property type="gene ID" value="ENSPMRG00000010639.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161574"/>
    <dbReference type="OMA" id="CRICYVD"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20345">
        <property type="entry name" value="BRcat_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16633">
        <property type="entry name" value="mRING-HC-C3HC3D_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047558">
        <property type="entry name" value="BRcat_RBR_HOIL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057468">
        <property type="entry name" value="HOIL-1/Sharpin_LTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047559">
        <property type="entry name" value="HOIL1_RBR_mRING-HC-C3HC3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF45">
        <property type="entry name" value="RANBP-TYPE AND C3HC4-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25393">
        <property type="entry name" value="LTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="254"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="482" mass="54733" checksum="D9FD85615C9CBEB3" modified="2025-10-08" version="2">MDEEEGDLALHLSTAIELGDEEEAMRCATLLAQQHAALRILLKESCYPTSEIRWDMKVQVEDATCSTSITTRVFQDYGFHPSVQRWIIGQCLCVDDRTVGSYGIRKDGDTAFLYLLSAKGAHLSEQRFKEDRDWVVLHFLGKFLPGHSRAPPPPPAAAPPPSPRSLPPPPHLPLQTGWSCPTCTFINKPTRPGCEMCSTDRPANYVVPGSYRPDEVELWRMQQEKEGILQYQKRQQNFQQLQQLDEAALVPNREEIECRICYLNVEPGEGVLLRECLHSFCRDCLRQLINCSEEPQVACPFRDDSYACSSHLQDREIRALVSWDEYERFLERRLAVAESRAQNSYHCQTADCLGWCIYEDDVNEFRCPICWALNCLVCKAIHEGMNCKQYQDKLQFQAHNDAAARETSNMLKLGEAMHCPVCRIVVQKKGGCDWLRCPVCQTEICWVTKGPRWGPGGPGDTSGGCRCNVDGERCHPQCQNCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZ68</accession>
    <name>A0A670IZ68_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hippocampus abundant transcript 1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing 14A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MFSD14A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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        <property type="nucleotide sequence ID" value="XM_028732684.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="120"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
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        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="37"/>
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        </location>
    </feature>
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        </location>
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            <end position="472"/>
        </location>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="491" mass="52968" checksum="6CD5973B4E27ECDF" modified="2020-06-17" version="1">MTQAGKKKKRAANRSILLAKKIIIKDGGTPQGIGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMRFSPESVAAFIAVLGILSIVAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELNEIPVTQNDLGDNVATQHHSQQNSIIPGPPFLFGACSVLLALLVALFIPEHTNLNGRSSNWKKHCGGHGHPHSPQAPGEAKEPLLQDTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J024</accession>
    <name>A0A670J024_PODMU</name>
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        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ELOVL1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
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        <property type="nucleotide sequence ID" value="XM_028733786.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF19">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="287" mass="33558" checksum="3A893C849D8B8CEE" modified="2020-06-17" version="1">MDSLVNMYQDFIKKADPRISSYPLMGSPLPMTGILLGYIYFVLSLGPRIMANRKPLNLRKFMIVYNSSMVALSLYIVYEFLMSGWLTGYTWRCDPVDQSQNPMALRMVHVAWVFIFSKYIELLDTVIFILRKKNEQVTFLHVFHHSVLPWSWWWGAKFGPGGMGSFHALVNSIVHVVMYFYYALSAAGPAYQKYLWWKKHITAIQLLQFVLVSIHISQYYFMPSCGYQYPIFIHLIWIYGVIFFLLFSNFWYHSYTRGKRLPKVMTQPQQNGFHENGAISNGKAKAN</sequence>
</entry>
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    <accession>A0A670J249</accession>
    <name>A0A670J249_PODMU</name>
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        <submittedName>
            <fullName evidence="17">Relaxin family peptide receptor 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="17" type="primary">RXFP1</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028744414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J249"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019739.1">
        <property type="protein sequence ID" value="ENSPMRP00000018573.1"/>
        <property type="gene ID" value="ENSPMRG00000012192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604361"/>
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    <dbReference type="GeneTree" id="ENSGT00940000158241"/>
    <dbReference type="OMA" id="ALMPIHI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hormone binding"/>
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        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:lung connective tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036446">
        <property type="term" value="P:myofibroblast differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:parturition"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="7tmA_RXFP1_LGR7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000023">
        <property type="entry name" value="Relaxin family peptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000434">
        <property type="entry name" value="Relaxin family peptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Relaxin family peptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000207">
        <property type="entry name" value="Relaxin family peptide receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008112">
        <property type="entry name" value="Relaxin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF68">
        <property type="entry name" value="RELAXIN RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01739">
        <property type="entry name" value="RELAXINR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025569633" evidence="15">
        <location>
            <begin position="20"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="632"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="424"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="747" mass="85155" checksum="BED63EF49D4A51B5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4M9</accession>
    <name>A0A670J4M9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Matrix Gla protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114606013</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the osteocalcin/matrix Gla protein family.</text>
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    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000018252.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="pmua:114606013"/>
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    <dbReference type="OMA" id="ERYYEMF"/>
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        <property type="component" value="Chromosome 10"/>
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    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058704">
        <property type="entry name" value="BGLAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035972">
        <property type="entry name" value="GLA-like_dom_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000294">
        <property type="entry name" value="GLA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027118">
        <property type="entry name" value="MGP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10109">
        <property type="entry name" value="MATRIX GLA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10109:SF0">
        <property type="entry name" value="MATRIX GLA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25890">
        <property type="entry name" value="BGLAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00069">
        <property type="entry name" value="GLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57630">
        <property type="entry name" value="GLA-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50998">
        <property type="entry name" value="GLA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0891">Chondrogenesis</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0301">Gamma-carboxyglutamic acid</keyword>
    <keyword evidence="9" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025490159" description="Matrix Gla protein" evidence="12">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Gla" evidence="13">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="96" mass="11392" checksum="A8FD90A0429E132A" modified="2020-06-17" version="1">MGNLQVLLFVTLVLTALFCCDGDMNRPLDEGVKISRETANAFVRRQKRSSPYYERYYERFKTPMEMKQEQCESHPLCDYYSEVVGFQTAYRYFFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8I0</accession>
    <name>A0A670J8I0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Speckle type BTB/POZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SPOP</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028557774.1">
        <property type="nucleotide sequence ID" value="XM_028701941.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028557775.1">
        <property type="nucleotide sequence ID" value="XM_028701942.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028557776.1">
        <property type="nucleotide sequence ID" value="XM_028701943.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028557777.1">
        <property type="nucleotide sequence ID" value="XM_028701944.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028557778.1">
        <property type="nucleotide sequence ID" value="XM_028701945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J8I0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021220.1">
        <property type="protein sequence ID" value="ENSPMRP00000019984.1"/>
        <property type="gene ID" value="ENSPMRG00000013026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581608"/>
    <dbReference type="KEGG" id="pmua:114581608"/>
    <dbReference type="CTD" id="8405"/>
    <dbReference type="GeneTree" id="ENSGT00940000154376"/>
    <dbReference type="OMA" id="IKFNYMW"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18518">
        <property type="entry name" value="BACK_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18279">
        <property type="entry name" value="BTB_POZ_SPOP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03774">
        <property type="entry name" value="MATH_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034089">
        <property type="entry name" value="SPOP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="374" mass="42136" checksum="53D6C34A6E760F05" modified="2020-06-17" version="1">MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNSMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVMETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAE1</accession>
    <name>A0A670JAE1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RIO kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">RIOK2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Associated with late 40S pre-ribosomal particles. Interacts with PLK1 (via its N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028605080.1">
        <property type="nucleotide sequence ID" value="XM_028749247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JAE1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022459.1">
        <property type="protein sequence ID" value="ENSPMRP00000021155.1"/>
        <property type="gene ID" value="ENSPMRG00000013751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606729"/>
    <dbReference type="KEGG" id="pmua:114606729"/>
    <dbReference type="CTD" id="55781"/>
    <dbReference type="GeneTree" id="ENSGT00390000003255"/>
    <dbReference type="OMA" id="ACPHLIA"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000208">
        <property type="term" value="P:positive regulation of ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000307">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="22">
        <location>
            <begin position="66"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="315"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="565" mass="64647" checksum="5C5B41453872B2C0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBP7</accession>
    <name>A0A670JBP7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C-type lectin APL-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114604829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the true venom lectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028601179.1">
        <property type="nucleotide sequence ID" value="XM_028745346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JBP7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022981.1">
        <property type="protein sequence ID" value="ENSPMRP00000021655.1"/>
        <property type="gene ID" value="ENSPMRG00000014060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604829"/>
    <dbReference type="KEGG" id="pmua:114604829"/>
    <dbReference type="GeneTree" id="ENSGT00940000161814"/>
    <dbReference type="OMA" id="QRFCKIK"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000015">
        <property type="entry name" value="C-type lectin Cal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01504">
        <property type="entry name" value="PNCREATITSAP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025454498" evidence="8">
        <location>
            <begin position="24"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="37"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        <source>
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    <sequence length="162" mass="18233" checksum="48EE73466D1AFF09" modified="2020-06-17" version="1">MGPASRLHLFLLGLLITSSISQGAPENLSCPENWLYIQKICYGVFDALASWEDAENNCQKYGPNAHLSSILTEAEATLISRYILDKHPGSEGIWIGLHDPFQSGKWRWADSSTVFFSPWIDSAPQPSWTALCAMLTYDKEFTKWKAAPCSLRLRYMCSLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC78</accession>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="component" value="Chromosome 12"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ePHD_AF10"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="protein AF-10 isoform X1"/>
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        <property type="entry name" value="PHD FINGER PROTEINS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="77"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1056" mass="112230" checksum="993F127D09CB2C20" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JDE8</accession>
    <name>A0A670JDE8_PODMU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
    </organism>
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <sequence length="135" mass="15284" checksum="BDD742789864798F" modified="2020-06-17" version="1">MRGGGGEEVRRQQSHMNAENITDFREAGGSLTEIKVEEEEEDPQSFEFPIEEEEEILSSVLPDSKKESDLPDFTHIEEFGNLSSAQARLAYEDSHLMISLEKQKLELEKQRLDIEAEQASTGKGEITNRARETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-methionyl-tRNA(fMet) + (6R)-10-formyltetrahydrofolate = N-formyl-L-methionyl-tRNA(fMet) + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:24381"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028561591.1">
        <property type="nucleotide sequence ID" value="XM_028705758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JEM4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022911.1">
        <property type="protein sequence ID" value="ENSPMRP00000021592.1"/>
        <property type="gene ID" value="ENSPMRG00000014009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584173"/>
    <dbReference type="KEGG" id="pmua:114584173"/>
    <dbReference type="CTD" id="123263"/>
    <dbReference type="GeneTree" id="ENSGT00390000017828"/>
    <dbReference type="OMA" id="GASPIHE"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12230:FF:000003">
        <property type="entry name" value="methionyl-tRNA formyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="11">
        <location>
            <begin position="106"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="12">
        <location>
            <begin position="235"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="377" mass="42002" checksum="6D76F8C0FE5595F7" modified="2020-06-17" version="1">MRGRILRAWRGRWSLGRGYASGAAEAPRREKPPWRVLFFGTDGFAAETLLALQAAREAKSGRLVDRLEVVTLHSQLPKGLPVKSCAEQLKLPIHLWPDVGLCDHFDVGVVASFGRLLSEDLILKFPYGVLNVHPSCLPRWRGPAPIIHTVLHGDTVTGVTIMQIRPKRFDVGPIIKQETFAVPPCCSAKELESMLSKLGASMLIAVLQNLPESLRNMTEQPKEGATFAPKASIAMSCIQWEEQTPEQILRMHRALGAMMPLQTLWMGTTVKLLDFVEVEALHDHNDRLAAENGTVPGSVFYHKQLQALVIRCKEGWVGVKAVVLKKKLTAADFYNGYLHPWFQQNSKMTPGTCRFQTLKLAPAKRSRQGTPLHARNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFE8</accession>
    <name>A0A670JFE8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Kirre like nephrin family adhesion molecule 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KIRREL2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598497.1">
        <property type="nucleotide sequence ID" value="XM_028742664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JFE8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024215.1">
        <property type="protein sequence ID" value="ENSPMRP00000022790.1"/>
        <property type="gene ID" value="ENSPMRG00000014799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603563"/>
    <dbReference type="KEGG" id="pmua:114603563"/>
    <dbReference type="CTD" id="84063"/>
    <dbReference type="GeneTree" id="ENSGT00940000160603"/>
    <dbReference type="OMA" id="TNFTCQA"/>
    <dbReference type="OrthoDB" id="10048737at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000077">
        <property type="entry name" value="Kirre like nephrin family adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000103">
        <property type="entry name" value="Kirre like nephrin family adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF51">
        <property type="entry name" value="KIN OF IRRE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025501969" evidence="14">
        <location>
            <begin position="27"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="118"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="228"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="314"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="398"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="549"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Pauperio F."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JJR2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026148.1">
        <property type="protein sequence ID" value="ENSPMRP00000024646.1"/>
        <property type="gene ID" value="ENSPMRG00000015914.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157037"/>
    <dbReference type="OMA" id="IMVCSAV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035240">
        <property type="term" value="F:dopamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001588">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gs"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008306">
        <property type="term" value="P:associative learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060292">
        <property type="term" value="P:long-term synaptic depression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045776">
        <property type="term" value="P:negative regulation of blood pressure"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001994">
        <property type="term" value="P:norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072593">
        <property type="term" value="P:reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045924">
        <property type="term" value="P:regulation of female receptivity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001992">
        <property type="term" value="P:regulation of systemic arterial blood pressure by vasopressin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001975">
        <property type="term" value="P:response to amphetamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042220">
        <property type="term" value="P:response to cocaine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046960">
        <property type="term" value="P:sensitization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000691">
        <property type="entry name" value="Predicted vertebrate-like dopamine D1-like G-protein coupled receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000497">
        <property type="entry name" value="Dopamine_D5_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000929">
        <property type="entry name" value="Dopamine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF136">
        <property type="entry name" value="D(1B) DOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00566">
        <property type="entry name" value="DOPAMINED1BR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00242">
        <property type="entry name" value="DOPAMINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="52"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="459" mass="50388" checksum="FB67292334214F6F" modified="2020-06-17" version="1">RVPPPPSPDPSPHPRLFGPAAAGAPPGSPAGGAPMVAAGSLLSLLVVWTLLGNVLVCAAIVGSRHLRAKVTHIFIVSLAVSDLLVALLVMPWKAAAEVAGYWPFGAFCSVWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPRVALAMVGLAWALSILISFLPVQLNWHKGPDPRAPWTCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHPQHHHSGLKSSLRKETKVLKTLSVIMGVFVCCWLPFFVLNCMVPFCDRSPGDPAAGLPCVSDTTFDVFVWFGWANSSLNPIIYAFNADFRKVFWRLLGCSRPCSGSPGETANLSHDSELGTERRGGIPVQWTGGGVKGWAYKACPEVPRETDRSALKGQLSSQKTAVWPQFGFYSDQSRKVSQATVFLLCFCSCNSHFGGFLFWEMDFLAGSWEPKTSKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJY0</accession>
    <name>A0A670JJY0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JJY0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026781.1">
        <property type="protein sequence ID" value="ENSPMRP00000025233.1"/>
        <property type="gene ID" value="ENSPMRG00000016332.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00970000197566"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF17">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjN" evidence="2">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="64" mass="7078" checksum="E835FDBACDA1CD87" modified="2020-06-17" version="1">SLPGPEAFVPPPECPVFEPSWEEFSDPLGFIGRIRPLAEKTGICKISKAGWVHTRKKGGKQEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JL18</accession>
    <name>A0A670JL18_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ubiquitin carboxyl-terminal hydrolase 32</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Deubiquitinating enzyme 32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin thioesterase 32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ubiquitin-specific-processing protease 32</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1. Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Golgi apparatus membrane</location>
            <topology evidence="16">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027278.1">
        <property type="protein sequence ID" value="ENSPMRP00000025698.1"/>
        <property type="gene ID" value="ENSPMRG00000016642.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155797"/>
    <dbReference type="OMA" id="FKADNRR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000081">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000128">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000068">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2230.10:FF:000004">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000018">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000110">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 32 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028135">
        <property type="entry name" value="Ub_USP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057368">
        <property type="entry name" value="USP32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14836">
        <property type="entry name" value="Ubiquitin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25265">
        <property type="entry name" value="USP32_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="25">
        <location>
            <begin position="369"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="24">
        <location>
            <begin position="733"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1370"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1422"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1370"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1389"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1426"/>
            <end position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1713" mass="193845" checksum="0C49C3DA8B50C0C8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JL40</accession>
    <name>A0A670JL40_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JL40"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027309.1">
        <property type="protein sequence ID" value="ENSPMRP00000025728.1"/>
        <property type="gene ID" value="ENSPMRG00000016663.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000626"/>
    <dbReference type="OMA" id="KPMGATS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:modulation of excitatory postsynaptic potential"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051388">
        <property type="term" value="P:positive regulation of neurotrophin TRK receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0097106">
        <property type="term" value="P:postsynaptic density organization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:receptor-mediated endocytosis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of neurotransmitter receptor localization to postsynaptic specialization membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:retrograde axonal transport"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="TMEM108"/>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 108"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="60"/>
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        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
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        <location>
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        </location>
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    </feature>
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        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="509" mass="54697" checksum="52F96B9A10F2865A" modified="2020-06-17" version="1">MFGKHTTLCTNDPAAMQGVSFCCRHLSPKPAILILCQFAMLWVFFTAISLLAGVLLILALTEELVFAVQAPFPSLASSWGLLTDNSNISAMGMTPGHKGRHTTKLLPTASLANFHPASSVETYTPSVGQKESTSSHPIGNKEPYHLNNQSALFSGKTLPQVNVSQVVNGNSTEFTEPYRKTGQHSPPTVRNWSPDHPFQSQSTAHSRSNGTMLVTTTDSLASFHSDTLGGLNTTGKGSSSELVTQETGLTTPANAPSAAPEMVTVPFKPQRYGIWDILGKNDSWVPSSQTTNQGPFFASPGTATAAAFGHSGQTGIDDVSSSHTTRNPNETSTALNPSGRANLPSAEPSTWMPSSTSTATGNFLNRLVPAGTWKPGMPGNISHASEGNTPQHRATICLSKVDIAWIILAISVPISSCSVLLTICCMRRKKKTSNPETNLSYWNNAITMDYFNRHAVELPREIQSLEISEDHLSEPRSPANGDYRDTGMVLVNPFCQETLFAGHEQVSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JL41</accession>
    <name>A0A670JL41_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Double PHD fingers 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DPF2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the requiem/DPF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JL41"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025126.1">
        <property type="protein sequence ID" value="ENSPMRP00000023677.1"/>
        <property type="gene ID" value="ENSPMRG00000015322.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155070"/>
    <dbReference type="OMA" id="GMGMDWD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:histone H3K14ac reader activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:histone H4K16ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905454">
        <property type="term" value="P:negative regulation of myeloid progenitor cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PHD1_DPF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15530">
        <property type="entry name" value="PHD2_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025750">
        <property type="entry name" value="DPF1-3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF7">
        <property type="entry name" value="ZINC FINGER PROTEIN UBI-D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14051">
        <property type="entry name" value="DPF1-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="320"/>
            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="377"/>
            <end position="427"/>
        </location>
    </feature>
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            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010539"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="441" mass="49905" checksum="B5B95BFAC10E337F" modified="2020-06-17" version="1">MFKRHLAPYLQMAGLCILRSFKNKVDLSSLKLAHPCSNACLLLPPTSLGEQYYKDAMEQCHNYNARLCAERSVRLPFLDSQTGVAQSNCYIWMEKRHRGPGLASGQLYSYPARRWRKKRRAHPPEDPRLSFPSIKPDTEQTLKKEGLISQDGSSLEALLRTDSLEKRSLPDPRTDEDSLGEFPVANSRARKRILEPDDFLDDLDDEDYEEDTPKRRGKGKAKGKGVGSARKKLDAAILEDRDKPYACDNSYKQKHTSKPPDRVCGKRYKNRPGLSYHYAHSHLAEEEGEDKEDSQPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRWQCIECKCCNICGTSENDDQLLFCDDCDRGYHMYCLTPPMSEPPEGSWSCHLCLDLLKEKASIYQNQNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JM55</accession>
    <name>A0A670JM55_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DIMT1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A670JM55"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026047.1">
        <property type="protein sequence ID" value="ENSPMRP00000024549.1"/>
        <property type="gene ID" value="ENSPMRG00000015852.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183142"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="11">
        <location>
            <begin position="122"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="410" mass="46200" checksum="544300EB1F5EB72C" modified="2020-06-17" version="1">MKRSGLYDRHLRLFFVCLLHERSLFCSGSPCAEVFPGRLACPLRYISLWPLELRAVRVTASSPELSATARKATWAGGGLTVILIMPKVKKPPRSRQQRPEGKAPGIRFNTGLGQHILKNPLIVNSIIEKASLYPTDVVLEVGPGTGNMTVKMLEKVKKVIACELDVKLAGELQKRVQGTPLANKLEIKIGDVLKSDLPFFDACVANLPYQISSPFVFKLLLHRPFFRCAVLMFQREFALRLVAKPGSPLYCRLSVNTQLLARVDHLMKVGKNNFKPPPKVESSVVRIEPRNPPPPINFQEWDGLLRIVFVRKNKTLAAVFNSNAVKKLLEKNYRIHCSQNNLEIPEDFSIGSFIQGILKDTGYAEKRARVMDIDDFISHSTDGLMFQKLTMKQFQGMSVVDMSTWNLSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JN55</accession>
    <name>A0A670JN55_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Na(+)/H(+) exchange regulatory cofactor NHE-RF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NHERF2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Endomembrane system</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JN55"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028098.1">
        <property type="protein sequence ID" value="ENSPMRP00000026488.1"/>
        <property type="gene ID" value="ENSPMRG00000017121.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182849"/>
    <dbReference type="OMA" id="MDPFAEM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06768">
        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000068">
        <property type="entry name" value="Na(+)/H(+) exchange regulatory cofactor NHE-RF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015098">
        <property type="entry name" value="EBP50_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017300">
        <property type="entry name" value="NHERF-1/NHERF-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF4">
        <property type="entry name" value="NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09007">
        <property type="entry name" value="EBP50_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037866">
        <property type="entry name" value="EBP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="43"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="193"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="382" mass="41530" checksum="E81656247AE0D9BA" modified="2020-06-17" version="1">MAKEQDAEAAGAASAAAAGAGGPPGSRARQQPPPPPPPLQPRLCHMLKGDNGYGFHLHGEKGKSGQFIRKVEPDSPAEAAGLRAGDRVVEVNGLNVEKETHHQVVQRIKAVEAETRLLVVDKETDEYLRSLQLTCTEEMARTGIVANPEVSPVKPTASDNNGERKKQSHTTMASSPSQIQDLNGQPKDLCPRLCHLKKGPTGYGFNLHSEKARPGQFIRSVDPDSPASKAGLRPQDKLVEVNGINVEGLKHSEVVSHIKSKEHEATLLVVDPETDEYFKKLGITPTEEHIGGKTFLLPRTNFSRGGRDFLNGGSMSSSHSDCQSPEKESEVGEPGKKDPFEESGLNLSPTAAEAKEKVRAKRVNKRAPQMDWNKKREIFSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQF3</accession>
    <name>A0A670JQF3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WDR41</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41. The complex is formed of two protomers, each individually consisting of one molecule each of C9orf72, SMCR8 and WDR41. The protomers homodimerize via an interaction between C9orf72 (via C-terminus) and SMCR8 (via N-terminus). Within each protomer SMCR8 (via DENN domain) acts as a bridging protein between WDR41 (via C-terminus and N-terminus) and C9orf72 (via C-terminus). The C9orf72-SMCR8 complex associates with the ULK1/ATG1 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028603865.1">
        <property type="nucleotide sequence ID" value="XM_028748032.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028603866.1">
        <property type="nucleotide sequence ID" value="XM_028748033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JQF3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027724.1">
        <property type="protein sequence ID" value="ENSPMRP00000026125.1"/>
        <property type="gene ID" value="ENSPMRG00000016907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606159"/>
    <dbReference type="KEGG" id="pmua:114606159"/>
    <dbReference type="CTD" id="55255"/>
    <dbReference type="GeneTree" id="ENSGT00390000017026"/>
    <dbReference type="OMA" id="VCLWNAQ"/>
    <dbReference type="OrthoDB" id="273067at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000564">
        <property type="entry name" value="WD repeat domain 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040102">
        <property type="entry name" value="WDR41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22805:SF2">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22805">
        <property type="entry name" value="WDR41-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25178">
        <property type="entry name" value="Beta-prop_WDR41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="316"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="456" mass="51281" checksum="CBEB1CC0D3D4D2D5" modified="2020-06-17" version="1">MLRWLIGGGREPQGLAEKSVQTIGEEQTQNPYTELLVLKGHHDIVRFLVPIDDYRFASAGDDGIVCLWNAQTGEKLFELHAHTQKITALASFPLSDTCEEKCHLILTAGADRTVIVWDCDNGRQVHKVSCFHSTVKCLTVLQRLDVWLSGGSDLCVWNRKLDLLCKTSHLIDADISAMIELPKNCVAAAVGKELIILRLKASRDGTEWDVIEVKRLLDHEDNIVSLVSVSDLTFATGSHVGELIVWDALDWTMHAYERRWDASLHVDPQQEIKLSHSQNEVSIQHLASDEECVFAAVGKGIYVYNLQMKRVIAFQKTAHDSTVLHITKVPNRQIISCSEDGSVRIWELREKQQLTAEPVPSGFFSMWGFGRTSKQASHTAKKPPESTTVFSLDLIGDLIGHSLAVQMFLYFSEHGLATCSADHLVILWKDGERESRLRSLLLFHKLEQSEDLQLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JU67</accession>
    <name>A0A670JU67_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sperm acrosome membrane-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SPACA3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ASTL.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JU67"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030446.1">
        <property type="protein sequence ID" value="ENSPMRP00000028703.1"/>
        <property type="gene ID" value="ENSPMRG00000018537.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161810"/>
    <dbReference type="OMA" id="IMETRAW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043159">
        <property type="term" value="C:acrosomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002080">
        <property type="term" value="C:acrosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007342">
        <property type="term" value="P:fusion of sperm to egg plasma membrane involved in single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16897">
        <property type="entry name" value="LYZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.530.10:FF:000001">
        <property type="entry name" value="Lysozyme C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019799">
        <property type="entry name" value="Glyco_hydro_22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000974">
        <property type="entry name" value="Glyco_hydro_22_lys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF25">
        <property type="entry name" value="SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00137">
        <property type="entry name" value="LYSOZYME"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00128">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 22 (GH22)" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="183" mass="20212" checksum="392F3C605862D327" modified="2020-06-17" version="1">MRSSDVHGSVHTPGISGEGLMVVFSFSIGCLGVPCPTCRSPGIMSFPTLFLGKKLLLLLPLLMCFTSRVGGKIFRRCELAHLLKVSGLEGYRGYSLADWVCLAFYESHFDTAIVDHEADGSTSNGIFQINSHLWCEDYKHFQPNFCKMHCSDLLTSDIKDDIVCAMRIAQGPRGLGAWYHCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUD5</accession>
    <name>A0A670JUD5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670JUD5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029788.1">
        <property type="protein sequence ID" value="ENSPMRP00000028076.1"/>
        <property type="gene ID" value="ENSPMRG00000018126.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282569"/>
    <dbReference type="OMA" id="HINTECH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="470"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="810" mass="89663" checksum="FC62D501E7F68861" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVI9</accession>
    <name>A0A670JVI9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxynucleoside triphosphate triphosphohydrolase SAMHD1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:46149"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dATP + H2O = 2'-deoxyadenosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67649"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dCTP + H2O = 2'-deoxycytidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80083"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:80084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:15194"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dTTP + H2O = thymidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80079"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:80080"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SAMHD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JVI9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030195.1">
        <property type="protein sequence ID" value="ENSPMRP00000028466.1"/>
        <property type="gene ID" value="ENSPMRG00000018204.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013867"/>
    <dbReference type="OMA" id="QVHGYIK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045088">
        <property type="term" value="P:regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000015">
        <property type="entry name" value="Deoxynucleoside triphosphate triphosphohydrolase SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2760:FF:000002">
        <property type="entry name" value="SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="15" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HD" evidence="25">
        <location>
            <begin position="160"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="583"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="617" mass="71087" checksum="CAB8FEC3835EA39C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JW01</accession>
    <name>A0A670JW01_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pseudouridylate synthase RPUSD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA pseudouridylate synthase domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RPUSD2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Pseudouridine synthase that catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028578587.1">
        <property type="nucleotide sequence ID" value="XM_028722754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JW01"/>
    <dbReference type="SMR" id="A0A670JW01"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031215.1">
        <property type="protein sequence ID" value="ENSPMRP00000029433.1"/>
        <property type="gene ID" value="ENSPMRG00000019032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593868"/>
    <dbReference type="KEGG" id="pmua:114593868"/>
    <dbReference type="CTD" id="27079"/>
    <dbReference type="GeneTree" id="ENSGT00420000029802"/>
    <dbReference type="OMA" id="QTYCKGR"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000010">
        <property type="entry name" value="RNA pseudouridine synthase domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="11">
        <location>
            <begin position="203"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="521" mass="58695" checksum="4DE53CE1614CCE26" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWG5</accession>
    <name>A0A670JWG5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cystatin E/M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CST6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JWG5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030541.1">
        <property type="protein sequence ID" value="ENSPMRP00000028791.1"/>
        <property type="gene ID" value="ENSPMRG00000018614.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161375"/>
    <dbReference type="OMA" id="ILVVPWQ"/>
    <dbReference type="OrthoDB" id="1908104at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000004">
        <property type="entry name" value="Cystatin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47033">
        <property type="entry name" value="CYSTATIN-M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47033:SF1">
        <property type="entry name" value="CYSTATIN-M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="7">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="162" mass="17534" checksum="5058BDE2A7F2A866" modified="2020-06-17" version="1">MAALTSSSFSAMAQLCSPVAMRTSSCLGLLLLFLPALFAGSIGMPGGLTPRSVSDPDVQKAAAFAVTAYNQASNNMFYCRQLSILKAESQVVEGVKYYLTVKLVNTLCEKKGGSNLSAEDLQRCSLPLEGEQQKQICEFHVWSRPWLSDTRLTHMSCRAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JX77</accession>
    <name>A0A670JX77_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JX77"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031707.1">
        <property type="protein sequence ID" value="ENSPMRP00000029898.1"/>
        <property type="gene ID" value="ENSPMRG00000019335.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175287"/>
    <dbReference type="OMA" id="NTFIHEH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="99" mass="10779" checksum="DEE684D038090112" modified="2020-06-17" version="1">MPPSLTQYQQSNPPLPAFGFQQGWGCGAMPEGRHTLGRPLPKDDTDKGQGGPRPQFYNTCERHCTSEDPVKVIPLANFIPAQAASISGKNATLIHEHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYC1</accession>
    <name>A0A670JYC1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Centromere protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CENPI</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028570781.1">
        <property type="nucleotide sequence ID" value="XM_028714948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JYC1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031325.1">
        <property type="protein sequence ID" value="ENSPMRP00000029536.1"/>
        <property type="gene ID" value="ENSPMRG00000019099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589021"/>
    <dbReference type="CTD" id="2491"/>
    <dbReference type="GeneTree" id="ENSGT00390000013235"/>
    <dbReference type="OMA" id="RVFKNYY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="706" mass="81429" checksum="E0B6FDE2F50C7504" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYF6</accession>
    <name>A0A670JYF6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Thyrotropin-releasing hormone-degrading ectoenzyme</fullName>
            <ecNumber evidence="18">3.4.19.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Pyroglutamyl-peptidase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">TRH-specific aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Thyroliberinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">TRHDE</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Specific inactivation of TRH after its release.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Release of the N-terminal pyroglutamyl group from pGlu-|-His-Xaa tripeptides and pGlu-|-His-Xaa-Gly tetrapeptides.</text>
            <dbReference type="EC" id="3.4.19.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="24">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.6" evidence="18"/>
    <dbReference type="RefSeq" id="XP_028601509.1">
        <property type="nucleotide sequence ID" value="XM_028745676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JYF6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030136.1">
        <property type="protein sequence ID" value="ENSPMRP00000028409.1"/>
        <property type="gene ID" value="ENSPMRG00000018339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604978"/>
    <dbReference type="KEGG" id="pmua:114604978"/>
    <dbReference type="CTD" id="29953"/>
    <dbReference type="GeneTree" id="ENSGT00940000155878"/>
    <dbReference type="OMA" id="HKRLVMG"/>
    <dbReference type="OrthoDB" id="6750768at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000005">
        <property type="entry name" value="Aminopeptidase N-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000039">
        <property type="entry name" value="thyrotropin-releasing hormone-degrading ectoenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000007">
        <property type="entry name" value="thyrotropin-releasing hormone-degrading ectoenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 24" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="30">
        <location>
            <begin position="175"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="28">
        <location>
            <begin position="396"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="29">
        <location>
            <begin position="706"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="23">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="25">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00066574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00072445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079759"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1052" mass="119979" checksum="2D6A2B4F111E19AD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZF7</accession>
    <name>A0A670JZF7_PODMU</name>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="PANTHER" id="PTHR31635:SF196">
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    <dbReference type="SUPFAM" id="SSF56672">
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    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="308"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029981.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="746" mass="87781" checksum="AC07EC1A2A8765C0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
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            <taxon>Unidentata</taxon>
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            <taxon>Laterata</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCAN_sf"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02023">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00096">
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    </dbReference>
    <dbReference type="Pfam" id="PF13465">
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00355">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="10">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="326" mass="37275" checksum="617F54660B0528D3" modified="2020-06-17" version="1">MDEQDSADPEAGRGHAIKTGSSGSFWGNSLQKVLGEEDTLCSEVQSQQFRQLCSLETEGPREVCNQFYRLDGQWLKPERHTKVQMLDLVIMEQFLAVLPLEMECWVRECGAETSSQAVALAEGFLLSQAEERKQAEQQVRETFLWMLLRGADELEIKNKRDHCKIHTVEKPYNYMVCGESFSQSFYSSSHQKNPIEKKLCQCLKCGNSFNSKRSLTSHQKTHSRKKSYQCLECGKSFSQSSYLISHQRTHTSEGLFPSKNHRGETLSVLWNVERVHKGKEKPYQCLECGSFGKVNLTSHQRIHTGEKPYQCLECGKSFSRNSSHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZN1</accession>
    <name>A0A670JZN1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JZN1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029902.1">
        <property type="protein sequence ID" value="ENSPMRP00000028182.1"/>
        <property type="gene ID" value="ENSPMRG00000018198.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189301"/>
    <dbReference type="OMA" id="QVEKSMM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="87" mass="9957" checksum="4E935CA9D8CABF58" modified="2020-06-17" version="1">KNSSQQKGKDDFLSLKDMTELLKSQAPTFLAACNRNRPDYMKELFKKADVDKTGQLTFEEFTKVFALLADDTHRLSHGEDRCGPDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZW5</accession>
    <name>A0A670JZW5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="28">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Ruffle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="28">Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="28"/>
    <dbReference type="AlphaFoldDB" id="A0A670JZW5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030614.1">
        <property type="protein sequence ID" value="ENSPMRP00000028859.1"/>
        <property type="gene ID" value="ENSPMRG00000017476.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158232"/>
    <dbReference type="OMA" id="DRHCLPC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038127">
        <property type="term" value="P:ERBB signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05109">
        <property type="entry name" value="PTKc_HER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12094">
        <property type="entry name" value="TM_ErbB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000009">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000184">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000007">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002828">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044912">
        <property type="entry name" value="Egfr_JX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049328">
        <property type="entry name" value="TM_ErbB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016245">
        <property type="entry name" value="Tyr_kinase_EGF/ERB/XmrK_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF137">
        <property type="entry name" value="RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21314">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000619">
        <property type="entry name" value="TyrPK_EGF-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0010">Activator</keyword>
    <keyword evidence="14 28 30" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="25" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 28" id="KW-0418">Kinase</keyword>
    <keyword evidence="17 28 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 28 31" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22 28" id="KW-0675">Receptor</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="21" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 28" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="18 28" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="34">
        <location>
            <begin position="677"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="999"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1083"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="29">
        <location>
            <position position="802"/>
        </location>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <begin position="683"/>
            <end position="691"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30 31">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00037619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR000619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR000619-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1206" mass="134868" checksum="B84BABBF9875EB04" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K018</accession>
    <name>A0A670K018_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Heat shock factor protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114589369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028571567.1">
        <property type="nucleotide sequence ID" value="XM_028715734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K018"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031283.1">
        <property type="protein sequence ID" value="ENSPMRP00000029495.1"/>
        <property type="gene ID" value="ENSPMRG00000019077.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589369"/>
    <dbReference type="KEGG" id="pmua:114589369"/>
    <dbReference type="GeneTree" id="ENSGT00940000163549"/>
    <dbReference type="OMA" id="EDQRFAY"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF454">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="472" mass="52340" checksum="D0744BBA27B6A218" modified="2020-06-17" version="1">MQKAPAAPAAAAAGVTARPVAPAILQLSPFLMKLWAIMEDSRNGSMITWSPDGQKVCILDDQRFAAQLLPKYFKHNNLSSFIRQLNLYGFKKVTSMRNETMVTCNNSTKEYQHPRFQKGKPELMASIQRKVYTCKEPAASSTKDQQAMLAEFRAMREQQDGISTKLDTVTRDTTSVLEGMGSLQQKEDQQQDVLSQILQIIMNCMSEKGRQDAQRKRHQNDASEAPRPKNSHPQAHSAREDRETAAVPGHSADHRNLVVTHNNMEGEAGDADGANNGQAVVREPHGTGEEGQHFMNLFISNTVKIDTQLSEEEQNDISKILSWEKRGTVMSQTGGAGAAEGARGGPSLEERNRDLEQQLALLAARLDERRTQDAQGKPTPIARKVAVVTGMNEEEAPRNDLQLIHNQNPMLGEPPTFKMEYDNSIPLEASVDIIPPVHFSDEALEECLGQVYQVDGAPTLLFLDQPVFFENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K099</accession>
    <name>A0A670K099_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cullin-4B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CUL4B</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15 16">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028570136.1">
        <property type="nucleotide sequence ID" value="XM_028714303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K099"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032084.1">
        <property type="protein sequence ID" value="ENSPMRP00000030256.1"/>
        <property type="gene ID" value="ENSPMRG00000019560.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588799"/>
    <dbReference type="KEGG" id="pmua:114588799"/>
    <dbReference type="CTD" id="8450"/>
    <dbReference type="GeneTree" id="ENSGT00940000155339"/>
    <dbReference type="OMA" id="NYQEQTW"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031465">
        <property type="term" value="C:Cul4B-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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</entry>
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        <scope>IDENTIFICATION</scope>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
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            <begin position="32"/>
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            <begin position="37"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="62388" checksum="6A0D48F03F9554A1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3I6</accession>
    <name>A0A670K3I6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanine nucleotide exchange factor subunit RIC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein RIC1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RAB6A-GEF complex partner protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RIC1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a complex with RGP1; the interaction enhances RAB6A GTPase activity. Interacts (via central domain) with RGP1. Interacts with RAB6A; the interaction is direct with a preference for RAB6A-GDP. Interacts (via C-terminus domain) with RAB33B; the interaction is direct with a preference for RAB33B-GTP. Interacts with GJA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RIC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028568876.1">
        <property type="nucleotide sequence ID" value="XM_028713043.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000034034.1">
        <property type="protein sequence ID" value="ENSPMRP00000032093.1"/>
        <property type="gene ID" value="ENSPMRG00000020809.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588111"/>
    <dbReference type="CTD" id="57589"/>
    <dbReference type="GeneTree" id="ENSGT00390000002955"/>
    <dbReference type="OMA" id="MVYDRAM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904888">
        <property type="term" value="P:cranial skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003330">
        <property type="term" value="P:regulation of extracellular matrix constituent secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000288">
        <property type="entry name" value="RAB6A-GEF complex partner protein 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="16">
        <location>
            <begin position="822"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1012"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1350"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1373"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1397"/>
            <end position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1417" mass="159052" checksum="D2A943A28B755596" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3S0</accession>
    <name>A0A670K3S0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS35 endosomal protein-sorting factor-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VPS35L</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K3S0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032671.1">
        <property type="protein sequence ID" value="ENSPMRP00000030805.1"/>
        <property type="gene ID" value="ENSPMRG00000019643.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011343"/>
    <dbReference type="OMA" id="RVEVCKN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="ESOPHAGEAL CANCER ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673:SF0">
        <property type="entry name" value="VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="962" mass="109176" checksum="B93E3BD5D03675C8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K579</accession>
    <name>A0A670K579_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small nuclear ribonucleoprotein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SNU13</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K579"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033255.1">
        <property type="protein sequence ID" value="ENSPMRP00000031355.1"/>
        <property type="gene ID" value="ENSPMRG00000020324.1"/>
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    <dbReference type="GeneTree" id="ENSGT00550000074840"/>
    <dbReference type="OMA" id="WACGLSR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
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    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001651">
        <property type="term" value="C:dense fibrillar component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005690">
        <property type="term" value="C:U4atac snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034512">
        <property type="term" value="F:box C/D sno(s)RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030622">
        <property type="term" value="F:U4atac snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="73" mass="7997" checksum="A3D0EC45F29DDDB9" modified="2020-06-17" version="1">MAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSITIKEGSQLKPQIQSVQQAIERLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5M7</accession>
    <name>A0A670K5M7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K5M7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031976.1">
        <property type="protein sequence ID" value="ENSPMRP00000030157.1"/>
        <property type="gene ID" value="ENSPMRG00000019496.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="EYACTTK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001808">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003000">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000806">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001119">
        <property type="entry name" value="zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="625" mass="71976" checksum="E10C771B169DFD9E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5Z7</accession>
    <name>A0A670K5Z7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K5Z7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034945.1">
        <property type="protein sequence ID" value="ENSPMRP00000032938.1"/>
        <property type="gene ID" value="ENSPMRG00000021347.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163371"/>
    <dbReference type="OMA" id="MNISHEP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00098">
        <property type="entry name" value="IgC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051755">
        <property type="entry name" value="Ig-like_CS_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19971">
        <property type="entry name" value="SIGNAL-REGULATORY PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="69"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="183"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="282"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="482" mass="52168" checksum="827FC5539502ABBB" modified="2020-06-17" version="1">MRLSYTRLAGLAAKKQKCFALVPGSRSSTEILSLSTLHSHPFCRNESKQGGSKMSSFSCLLLFLQGAWAAVIIQVPSSPVQAGPHSNVSLPCHFSLDPPRPINVDFLIVRWSLRGKNVAKFDTNITVFRPRGAVLDARRLPEGNATLYLSDVREEDAGEYTCFVLHTPDSAEGKVALKLEAPPHLTLGSTEVPLGKPSTLTCAASDFYPDGVSVKWLRGSETLKVDSPPAKLEANYHFNAESVLNFTPQISDAGVTFSCHIQHPAAKDPIRKDFELKVVARPQLHIVTRPSGKTFLVAECLVCGFYPENVEVQGLQNGEPIQGRIYKSGLEKNSNGTFSTGSVFFPKQGHFAANFTCQVQHEALEAPLEETIPWEPEGEGAGITHPSSPECITKSPRPKLKPASPTDPPPAPGSPMTWLLGPLGLALGLVLGGGAMLMYQRRRAAKNEQAEPNDQTLLKKMGEDAESHEGKASGKSLDGTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7B6</accession>
    <name>A0A670K7B6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol transfer protein alpha isoform</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 &gt; C16:0 &gt; C18:1 &gt; C18:0 &gt; C20:4 and for PI is C16:1 &gt; C16:0 &gt; C18:1 &gt; C18:0 &gt; C20:4 &gt; C20:3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38572"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7B6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034136.1">
        <property type="protein sequence ID" value="ENSPMRP00000032195.1"/>
        <property type="gene ID" value="ENSPMRG00000020862.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155101"/>
    <dbReference type="OMA" id="QHNVHEL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08888">
        <property type="entry name" value="SRPBCC_PITPNA-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000004">
        <property type="entry name" value="Phosphatidylinositol transfer protein alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF28">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025486996" description="Phosphatidylinositol transfer protein alpha isoform" evidence="15">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="16">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="266" mass="31044" checksum="57D3BE05A96912BD" modified="2020-06-17" version="1">GSNPPKHLVLLPLSGLILSRYQVGQLYSVAEASKNETGGGEGVEVLVNEPYERDGERGQYTHKIYHLQSKVPPFVKMLAPEGALNIHEKAWNAYPYCRTDDFLIKIETWHKPDLGMQENVHKLDPNEWKNVEAVYIDIADRSQVLSRDYKPEEDPSKFKSTKTGRGPLGPNWRKELGKQTDCPYMCAYKLVTVKFKWWGLQNKVENFIQKQERRLFTNFHRQLFCWLDKWVDLTMEDIRRMEDETKRQLDEMRQKDPLKGTSAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9L8</accession>
    <name>A0A670K9L8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myosin light chain 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MYL9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K9L8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034234.1">
        <property type="protein sequence ID" value="ENSPMRP00000032279.1"/>
        <property type="gene ID" value="ENSPMRG00000020929.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155458"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043149">
        <property type="term" value="P:stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000010">
        <property type="entry name" value="Myosin regulatory light chain 2, atrial isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="176" mass="19415" checksum="567AB5622A96BF65" modified="2020-06-17" version="1">MAKSFGVGGNRLGKVSAPLAASSARSRSFQTRAIENNTARSRIFSAGIAGGSAFLCRLGTSFCVTGKNPTDEYLEGMMSEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGFIHEDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTRILKHGAKDKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KA98</accession>
    <name>A0A670KA98_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Plasminogen activator</fullName>
            <ecNumber evidence="14">3.4.21.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PLAT</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.</text>
            <dbReference type="EC" id="3.4.21.68"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.68" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A670KA98"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033670.1">
        <property type="protein sequence ID" value="ENSPMRP00000031742.1"/>
        <property type="gene ID" value="ENSPMRG00000020565.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158930"/>
    <dbReference type="OMA" id="WCYIFKA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097180">
        <property type="term" value="C:serine protease inhibitor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035821">
        <property type="term" value="P:modulation of process of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031639">
        <property type="term" value="P:plasminogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048008">
        <property type="term" value="P:platelet-derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014909">
        <property type="term" value="P:smooth muscle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099183">
        <property type="term" value="P:trans-synaptic signaling by BDNF, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.20.10:FF:000001">
        <property type="entry name" value="Urokinase-type plasminogen activator"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000083">
        <property type="entry name" value="Fibronectin_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026280">
        <property type="entry name" value="Tissue_plasm_act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF42">
        <property type="entry name" value="TISSUE-TYPE PLASMINOGEN ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001145">
        <property type="entry name" value="Tissue_plasm_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00058">
        <property type="entry name" value="FN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        <source>
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        <source>
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    <sequence length="556" mass="62779" checksum="95F450379717C74C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAE1</accession>
    <name>A0A670KAE1_PODMU</name>
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        <submittedName>
            <fullName evidence="11">Importin 4</fullName>
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        <name evidence="11" type="primary">IPO4</name>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Laterata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAV2</accession>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shroom family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KAV2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034715.1">
        <property type="protein sequence ID" value="ENSPMRP00000032739.1"/>
        <property type="gene ID" value="ENSPMRG00000021213.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159479"/>
    <dbReference type="OMA" id="THEQFAD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014799">
        <property type="entry name" value="ASD2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027685">
        <property type="entry name" value="Shroom_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012">
        <property type="entry name" value="APICAL PROTEIN/SHROOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012:SF35">
        <property type="entry name" value="PROTEIN SHROOM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08687">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51307">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASD2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="155" mass="17975" checksum="5B222F121D1467B7" modified="2020-06-17" version="1">MVLGREVENHVKGVCKPHEYEKFRLFIGDLEKVVNLLLSLSGRLARVENALSSLDLDLPLFSLPQIKLALLEKKRQLMAQLEDAKELQDHVSRRERLVFTSVSRCLPAEQLQDYQHFVRMKSALIIQQRQLEDKIKLGEEQLRCLRESLQPECLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCW5</accession>
    <name>A0A670KCW5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KCW5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036300.1">
        <property type="protein sequence ID" value="ENSPMRP00000034210.1"/>
        <property type="gene ID" value="ENSPMRG00000022213.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154737"/>
    <dbReference type="OMA" id="XIRQASS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07613">
        <property type="entry name" value="BAR_Endophilin_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000021">
        <property type="entry name" value="Endophilin-A2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF50">
        <property type="entry name" value="ENDOPHILIN-A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="10">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="296" mass="33564" checksum="940F3F11F4C91DB4" modified="2020-06-17" version="1">MSVAGLKKQFHKATQKVSEKVGGAEGTKLDEDFKEMERKVDVTSRAVMEIMARTTEYLQPNPASRARLNMLNTMSKIRGQEKGPGYQQAEALLADAMLKFGKELGDDCNFGPALGDVGEAMRELSEVKDSLDIDVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRAALEKFDESKEVAELSMFNLLEMDIEQVSQLSALVQAQLEYHRQATQILQQVSSKLEERIKDASVQPRREYQPKPRMSLDLSENNQHNGGLSNATTPKPSSKRRWKGGVGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEJ7</accession>
    <name>A0A670KEJ7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SMARCA2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000035261.1">
        <property type="protein sequence ID" value="ENSPMRP00000033237.1"/>
        <property type="gene ID" value="ENSPMRG00000021519.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154821"/>
    <dbReference type="OMA" id="VNYISHT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
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    <sequence length="1587" mass="180226" checksum="CE2AA39C9862A980" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFY0</accession>
    <name>A0A670KFY0_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 10</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="primary">CNOT10</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="2">Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
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            <location evidence="2">Cytoplasm</location>
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        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CNOT10 family.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of translation"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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</entry>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="732"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="3">
        <location>
            <begin position="200"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="762" mass="83587" checksum="F7013C9CF057C4CB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KN93</accession>
    <name>A0A670KN93_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">small monomeric GTPase</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RAB27A</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028562319.1">
        <property type="nucleotide sequence ID" value="XM_028706486.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028562320.1">
        <property type="nucleotide sequence ID" value="XM_028706487.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028562321.1">
        <property type="nucleotide sequence ID" value="XM_028706488.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028562323.1">
        <property type="nucleotide sequence ID" value="XM_028706490.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028562324.1">
        <property type="nucleotide sequence ID" value="XM_028706491.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028562325.1">
        <property type="nucleotide sequence ID" value="XM_028706492.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028562326.1">
        <property type="nucleotide sequence ID" value="XM_028706493.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028562327.1">
        <property type="nucleotide sequence ID" value="XM_028706494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KN93"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038635.1">
        <property type="protein sequence ID" value="ENSPMRP00000036467.1"/>
        <property type="gene ID" value="ENSPMRG00000023529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584543"/>
    <dbReference type="KEGG" id="pmua:114584543"/>
    <dbReference type="CTD" id="5873"/>
    <dbReference type="GeneTree" id="ENSGT00940000156218"/>
    <dbReference type="OMA" id="MHAYTED"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097278">
        <property type="term" value="P:complement-dependent cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043316">
        <property type="term" value="P:cytotoxic T cell degranulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990182">
        <property type="term" value="P:exosomal secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032402">
        <property type="term" value="P:melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036257">
        <property type="term" value="P:multivesicular body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071985">
        <property type="term" value="P:multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043320">
        <property type="term" value="P:natural killer cell degranulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903435">
        <property type="term" value="P:positive regulation of constitutive secretory pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050766">
        <property type="term" value="P:positive regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903428">
        <property type="term" value="P:positive regulation of reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903307">
        <property type="term" value="P:positive regulation of regulated secretory pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04127">
        <property type="entry name" value="Rab27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000402">
        <property type="entry name" value="Ras-related protein Rab-27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041837">
        <property type="entry name" value="Rab27a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0636">Prenylation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="221" mass="25077" checksum="A18872D9A6B7DED4" modified="2020-06-17" version="1">MSDGDYDYLIKFLALGDSGVGKTSFLYQYTDGKFNSKFITTVGIDFREKRVVYRSNGPDGISGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNIRNWMSQLQTHAYCENPDVVLCGNKSDLEEQRVVKEEDAKELAEKHGIPYFETSAANGANVSKAIETLLDLIMKRMERCVDKSWIPEGVVQPNGHSSTEQLSEEKEKSKCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HL10</accession>
    <name>A0A670HL10_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil alpha-helical rod protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-helical coiled-coil rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114591995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be a regulator of keratinocyte proliferation or differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HL10"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000536.1">
        <property type="protein sequence ID" value="ENSPMRP00000000509.1"/>
        <property type="gene ID" value="ENSPMRG00000000362.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153251"/>
    <dbReference type="OMA" id="CFANRRV"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009800">
        <property type="entry name" value="HCR"/>
    </dbReference>
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        <property type="entry name" value="COILED-COIL ALPHA-HELICAL ROD PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46822:SF1">
        <property type="entry name" value="COILED-COIL ALPHA-HELICAL ROD PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07111">
        <property type="entry name" value="HCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="123"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="431"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="728"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="902" mass="102116" checksum="2941F861BA286A55" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HL20</accession>
    <name>A0A670HL20_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZIP11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 39 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Zrt- and Irt-like protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SLC39A11</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028569681.1">
        <property type="nucleotide sequence ID" value="XM_028713848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HL20"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000190.1">
        <property type="protein sequence ID" value="ENSPMRP00000000181.1"/>
        <property type="gene ID" value="ENSPMRG00000000120.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588498"/>
    <dbReference type="CTD" id="201266"/>
    <dbReference type="GeneTree" id="ENSGT00390000006167"/>
    <dbReference type="OMA" id="MIFVVIE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF211">
        <property type="entry name" value="ZINC TRANSPORTER ZIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="335" mass="35479" checksum="EEDD6992441DF3B2" modified="2020-06-17" version="1">MLLGYSPVSQALLGTFFTWGLTAAGSALVFIFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAIELAEDSGKFGAFAFFPVAVGFTLGAAFVYFADLILPWLGITEPPHTALTLSYDSRAAKEKYEQQPTHRRQHDNELSIRIDKGENGEPYQRKKGAGAPQPDVPAPSQNLRDSTSAPASNSWRRIMLLILAITIHNIPEGLAVGVGFGAVGKSASATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGIFGAFAIVLAEPLLPYALAFAAGAMVYVVMDDIIPEAQISGNGKLASWTSILGFVVMMSLDVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HND5</accession>
    <name>A0A670HND5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HND5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001461.1">
        <property type="protein sequence ID" value="ENSPMRP00000001374.1"/>
        <property type="gene ID" value="ENSPMRG00000001034.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182788"/>
    <dbReference type="OMA" id="WLPHEQP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="670"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="513"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="765" mass="86087" checksum="ACFB4039D0ECCC94" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNU4</accession>
    <name>A0A670HNU4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCAN box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HNU4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001624.1">
        <property type="protein sequence ID" value="ENSPMRP00000001524.1"/>
        <property type="gene ID" value="ENSPMRG00000001144.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="OMA" id="NIEDPCH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="3">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="145" mass="16795" checksum="E42B4FD0369B4B20" modified="2020-06-17" version="1">MMEEDSGEPEARRGPQTTKTGSSEELWGETTEKRLREEDTLSSNVPQQQFRQFHYTEAKGPREVCSRLHHLCRQWLKPELHTKSQILDLVILEQFLAVLPPEMENWVRECGQPGISQSHGAHCVNNVYIARRSGESFIHCYCELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQ51</accession>
    <name>A0A670HQ51_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetate--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670HQ51"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001928.1">
        <property type="protein sequence ID" value="ENSPMRP00000001813.1"/>
        <property type="gene ID" value="ENSPMRG00000001336.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158550"/>
    <dbReference type="OMA" id="AIKASWP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF110">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL"/>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="520" mass="57784" checksum="FC6F4BCA94698170" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQD9</accession>
    <name>A0A670HQD9_PODMU</name>
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        <recommendedName>
            <fullName evidence="6">Fibronectin type-II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQD9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002156.1">
        <property type="protein sequence ID" value="ENSPMRP00000002029.1"/>
        <property type="gene ID" value="ENSPMRG00000001490.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156671"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
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        <property type="entry name" value="Kringle-like"/>
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        <property type="entry name" value="fn2"/>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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            <begin position="27"/>
            <end position="137"/>
        </location>
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        <location>
            <begin position="108"/>
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        </location>
    </feature>
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        <location>
            <begin position="34"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="137" mass="15208" checksum="4E0EAEF3B9ECEB78" modified="2020-06-17" version="1">EQLKVQLKVMREYLAVLLVALGLVAADEEGIQEEPFESKTALPSEEQVKEHSTGTHVVAGQIFIVSDEPKKERTLEELNSLELSSLSSKDLEEVKAQKAVFTAIGGTADGERCYFPFIFLEKEYSECTADGREDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQJ8</accession>
    <name>A0A670HQJ8_PODMU</name>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQJ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001432.1">
        <property type="protein sequence ID" value="ENSPMRP00000001347.1"/>
        <property type="gene ID" value="ENSPMRG00000001016.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="OMA" id="CERDVAR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000625">
        <property type="entry name" value="Zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="590" mass="66051" checksum="38F8CCD1B8A72CF6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HS90</accession>
    <name>A0A670HS90_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein VTA1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">VTA1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028579397.1">
        <property type="nucleotide sequence ID" value="XM_028723564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HS90"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002230.1">
        <property type="protein sequence ID" value="ENSPMRP00000002095.1"/>
        <property type="gene ID" value="ENSPMRG00000001538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594201"/>
    <dbReference type="KEGG" id="pmua:114594201"/>
    <dbReference type="CTD" id="51534"/>
    <dbReference type="GeneTree" id="ENSGT00390000011342"/>
    <dbReference type="OMA" id="AYWCEYH"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein VTA1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.270:FF:000001">
        <property type="entry name" value="vacuolar protein sorting-associated protein VTA1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="13">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="14">
        <location>
            <begin position="261"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="157"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063366"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="302" mass="33368" checksum="964DB0C3845668A5" modified="2020-06-17" version="1">MAASGLPPLPPQFKPIQHFLRTAQELDKREPVVAYYCRLYAMQTGMKIDSKNPECRKFLCKLMDQLEATKKQLGDNEAITQEIVGCAHVENYALKMFLYADNEDRAGQFHKNMIKSFYTASLLIDVLTVFGELTDENVQHRKYARWKAAYIHNCLKNGETPQSGPTGMEGEYDENEEVGSPAPLNPGSHSPSAFESSDVPTSNYTGIQIPPGAHAPANTPAEVPHSTGVTSSTIQPTPQNIPIVDPSLYNVQPTGEIRLSPEDFAKAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HSD1</accession>
    <name>A0A670HSD1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HSD1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002599.1">
        <property type="protein sequence ID" value="ENSPMRP00000002441.1"/>
        <property type="gene ID" value="ENSPMRG00000001770.1"/>
    </dbReference>
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    <dbReference type="OMA" id="TVVLDNW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41693:SF2">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41693">
        <property type="entry name" value="HEME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025409089" evidence="2">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="168" mass="19062" checksum="165EC6B0A5510778" modified="2020-06-17" version="1">MRQIFSLLLLVAICCAAKPKRQQATSEWDYRSEAEKVNMRGCANLTVVLDNWKFAIVSQMKNLLLFDHQSVLPDYGRIKPLSDALNDLYLEFNALKERLGELTTRFEGVESFVDEMNKKGQSQPAAKTPLRVAQPEVEKASFPLPAKRRRVQIRNGRKPTEPLTGGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTZ3</accession>
    <name>A0A670HTZ3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromobox 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CBX8</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028570875.1">
        <property type="nucleotide sequence ID" value="XM_028715042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HTZ3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003441.1">
        <property type="protein sequence ID" value="ENSPMRP00000003209.1"/>
        <property type="gene ID" value="ENSPMRG00000002272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589052"/>
    <dbReference type="KEGG" id="pmua:114589052"/>
    <dbReference type="CTD" id="57332"/>
    <dbReference type="GeneTree" id="ENSGT00940000158476"/>
    <dbReference type="OMA" id="HPENHGH"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061628">
        <property type="term" value="F:histone H3K27me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097027">
        <property type="term" value="F:ubiquitin-protein transferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18627">
        <property type="entry name" value="CD_polycomb_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000006">
        <property type="entry name" value="Chromobox protein homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033773">
        <property type="entry name" value="CBX7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052458">
        <property type="entry name" value="PcG_PRC1-like_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389:SF1">
        <property type="entry name" value="CHROMOBOX PROTEIN HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17218">
        <property type="entry name" value="CBX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="364" mass="40528" checksum="0C5F856BA672B409" modified="2020-06-17" version="1">MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRVPYPGRSPQEMGSTSRAREGLRQIPLPPQSTSATATTNTSRVETIQENRIGAEEDRSEAAFKKRGPKPRKELYKDLPEPADVTCKRKSVEPGDKAVVDYLKARKLEEAANPGTAKFSSGHSVIQLARRREPELPSAVSSPRAEAGIKLCAPEAYPPRLTKHRADFLDPKGQSSLDLGAPKILHSSASQGGLYRDGIGTQAGRPSLIARIPVSRILGDPEEEAWSPSLNNLEKVVVTDVTSNFLTVTIKESSTDQGFFKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HV53</accession>
    <name>A0A670HV53_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HV53"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003841.1">
        <property type="protein sequence ID" value="ENSPMRP00000003583.1"/>
        <property type="gene ID" value="ENSPMRG00000002506.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162510"/>
    <dbReference type="OMA" id="MVRLVIP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046222">
        <property type="term" value="P:aflatoxin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000010">
        <property type="entry name" value="cytochrome P450 2W1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008069">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF302">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01686">
        <property type="entry name" value="EP450ICYP2D"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="493" mass="56272" checksum="7464093E92DACA87" modified="2020-06-17" version="1">MVWMEPIPVLFLFILMVYFVLKLGTFWNKSSQNLPPGPRPLPLIGNLHIMDLKRPHRTMLKLSKQYGPVFSIQMGPRKTVVLTGYETVKEALVNQADAFADRPIVPLFQELAQGVILSNGENWKVMRRFALSTLRDYGMGKRTIEDRIVEECSVLIKKFESYEGNPFETTTIMNAAVANIIVAILLDKRFDYEDPTYIRLLKLINESAMLFGSFSVTLYNMFPALGFLLGARKTVMQNRDEMFAFINATFIKHLRDLDENDQRSFIDSFLIQQQEKKKTTNAYFHNENLKAVVGNLFAAGMETTSTTLSWGLLLMMKYPEIQIKVQEEIAKVVGSSQPRIEHRTKMPYTDAVVHEIQRFANIIPTNLPHATATDVTLNGYFIPKGTFIIPLLSSVLQDESQWEKPHKFYPEHFLNSEGKFIKRDAFMPFSAGRRACLGETLAKTELFLFFTSLLQRFTFQPPPGTSQEDLDLTPAVGLTTSPMPHQLCALPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWR1</accession>
    <name>A0A670HWR1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FKBP prolyl isomerase like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FKBPL</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028575778.1">
        <property type="nucleotide sequence ID" value="XM_028719945.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575779.1">
        <property type="nucleotide sequence ID" value="XM_028719946.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575780.1">
        <property type="nucleotide sequence ID" value="XM_028719947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HWR1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004461.1">
        <property type="protein sequence ID" value="ENSPMRP00000004179.1"/>
        <property type="gene ID" value="ENSPMRG00000002864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592081"/>
    <dbReference type="KEGG" id="pmua:114592081"/>
    <dbReference type="CTD" id="63943"/>
    <dbReference type="GeneTree" id="ENSGT00920000149187"/>
    <dbReference type="OMA" id="WTELTIG"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF10">
        <property type="entry name" value="FK506-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="313" mass="33804" checksum="92463485E3EF347D" modified="2020-06-17" version="1">MMASTEPVTEKMPGKKPNQGSAVGQGSICGTSVGSGGEKERRAEDLKENLPPRDPAGRDVPWACPDGTFVKLVLEAGTGLDKPKEGSLCQVFLEAEPGSPLSYPTHRWAEMELGGGDAEWDGVVDRCLETMLAGEQAEARLAAGGTMTIRLASFTEAKDTWEMSAAEKWDLVLSNKERGGELYRAGDVAAAARRYARALRLLVVAAPPPDYDQIKAELHANLAACQLRLHQPANAACNCTKTLALQPANTKALFRRGLAHDAMNDLEGAAQDLKGVLQVEPGNRAARRELERVMERIRARDAKLARAMQKMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWT2</accession>
    <name>A0A670HWT2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex I-B12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NDUFB3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028606930.1">
        <property type="nucleotide sequence ID" value="XM_028751097.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028606941.1">
        <property type="nucleotide sequence ID" value="XM_028751108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HWT2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004445.1">
        <property type="protein sequence ID" value="ENSPMRP00000004163.1"/>
        <property type="gene ID" value="ENSPMRG00000002852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607676"/>
    <dbReference type="KEGG" id="pmua:114607676"/>
    <dbReference type="CTD" id="4709"/>
    <dbReference type="GeneTree" id="ENSGT00390000010316"/>
    <dbReference type="OMA" id="EAWRYEP"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="96" mass="11131" checksum="196E7A9087BE4CCA" modified="2020-06-17" version="1">MGHGHEHGPVKVEYPDPKVWKVEGTPLQDIQERLARRGLKDPWLRNEAWRYMGTFAKPVTIMDVLRKGFKWGFTAFVVALAVEYTLFPPKKDKGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HYR7</accession>
    <name>A0A670HYR7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HYR7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005113.1">
        <property type="protein sequence ID" value="ENSPMRP00000004793.1"/>
        <property type="gene ID" value="ENSPMRG00000003297.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154411"/>
    <dbReference type="OMA" id="RLYICEG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000029">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="247"/>
            <end position="274"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="295" mass="32568" checksum="D4776111D07CD16E" modified="2020-06-17" version="1">MGGVTLLFPGEQVSLLDSYPRAVSGDTMQADDGGDAILLGSEERGKIYPGETPRYCPLYAKSFGGSPSRERPVAGDKCYKCSECGKGFKKRSALLTHDRTHTGEKPYGCAECGNSFSNKSSLTRHKRKHTGEKPFGCPDCGKRFSQSSSLIRHLRNHTGLRPYRCSACGKSFKQSSSLLVHRRTHTGETPYSCSVCGKRFSQSSNLVKHERIHTGEKPYGCAECGNTFSNKSSLTRHKRNHTGQKPYKCPQCGKRFKQSSGLLKHERAHARKSLAKLPEPSKRLDAMRAHIGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HYU2</accession>
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        <submittedName>
            <fullName evidence="3">Axonemal dynein light chain domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AXDND1</name>
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    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
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                <person name="Font E."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Chromosome 6"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="AXONEMAL DYNEIN LIGHT CHAIN DOMAIN-CONTAINING PROTEIN 1"/>
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        <property type="entry name" value="Ax_dynein_light"/>
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    </dbReference>
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    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="739" mass="85867" checksum="375A45C2D6244338" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ72</accession>
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        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain containing 4B</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">MFSD4B</name>
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    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028579023.1">
        <property type="nucleotide sequence ID" value="XM_028723190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HZ72"/>
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        <property type="protein sequence ID" value="ENSPMRP00000005004.1"/>
        <property type="gene ID" value="ENSPMRG00000003439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594049"/>
    <dbReference type="KEGG" id="pmua:114594049"/>
    <dbReference type="CTD" id="91749"/>
    <dbReference type="GeneTree" id="ENSGT00530000063320"/>
    <dbReference type="OMA" id="IPWCKKA"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_NaGLT1_MFSD4B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sodium-dependent glucose transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="607" mass="64488" checksum="F63FB93135069470" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZH8</accession>
    <name>A0A670HZH8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LLGL scribble cell polarity complex component 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lethal(2) giant larvae protein homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LLGL2</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6. The complex is enhanced during mitosis. Interacts with DCAF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HZH8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004861.1">
        <property type="protein sequence ID" value="ENSPMRP00000004557.1"/>
        <property type="gene ID" value="ENSPMRG00000002877.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182906"/>
    <dbReference type="OMA" id="TKNHSRP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051294">
        <property type="term" value="P:establishment of spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016332">
        <property type="term" value="P:establishment or maintenance of polarity of embryonic epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015820">
        <property type="term" value="P:L-leucine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000170">
        <property type="entry name" value="lethal(2) giant larvae protein homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000496">
        <property type="entry name" value="LLGL2, scribble cell polarity complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF20">
        <property type="entry name" value="LLGL SCRIBBLE CELL POLARITY COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="15">
        <location>
            <begin position="273"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1008" mass="113600" checksum="25C2DF1C16AE81CD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZL4</accession>
    <name>A0A670HZL4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PARP4 MVP-ID C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HZL4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004970.1">
        <property type="protein sequence ID" value="ENSPMRP00000004660.1"/>
        <property type="gene ID" value="ENSPMRG00000003192.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160555"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031273">
        <property type="entry name" value="PARP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058904">
        <property type="entry name" value="PARP4_MVP-ID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46530">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46530:SF1">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26156">
        <property type="entry name" value="PARP4_MVP-ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP4 MVP-ID C-terminal" evidence="1">
        <location>
            <begin position="375"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="517" mass="55538" checksum="DDE2BEC347E14847" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4X8</accession>
    <name>A0A670I4X8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">AFMID</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670I4X8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007058.1">
        <property type="protein sequence ID" value="ENSPMRP00000006625.1"/>
        <property type="gene ID" value="ENSPMRG00000004478.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011093"/>
    <dbReference type="OMA" id="WAVAMPS"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BD-FAE-like_dom"/>
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        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
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        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="3">
        <location>
            <begin position="33"/>
            <end position="37"/>
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        <location>
            <position position="102"/>
        </location>
    </feature>
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            <position position="184"/>
        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="241" mass="26605" checksum="9DCC982BC09B554C" modified="2025-10-08" version="2">MLNVPYGLGEGEKLDVYLPKEHTETFPLVLYIHGGYWQFLSKDASGFAAGPLATHGVVLAAVGYDVAPKGQLEVMVRQVRRSVAFAVQQYTGISGVYLLGHSAGAHLAAMVLSTDWAEFGVVPNIKGAFLVSGLYDLEPITHTYVNDVLHMSREVALQNSPLRCVPKLEGRRNCQVLITVAQHDSPEFHRQSQEYFEALRAAGWSASLLDIGDTDHFDVIEKLSQEDYFLTQVILKMISRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I7S8</accession>
    <name>A0A670I7S8_PODMU</name>
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        <recommendedName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rho GTPase-activating protein 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">WAVE-associated Rac GTPase-activating protein</fullName>
        </alternativeName>
    </protein>
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        <name evidence="16" type="primary">SRGAP3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Homodimer. Forms a heterooligomer with SRGAP1 and SRGAP2 through its F-BAR domain. Interacts with WASF1. Probably interacts with ROBO1. Interacts with FASLG.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028575149.1">
        <property type="nucleotide sequence ID" value="XM_028719316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I7S8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008332.1">
        <property type="protein sequence ID" value="ENSPMRP00000007786.1"/>
        <property type="gene ID" value="ENSPMRG00000005264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591797"/>
    <dbReference type="KEGG" id="pmua:114591797"/>
    <dbReference type="CTD" id="9901"/>
    <dbReference type="GeneTree" id="ENSGT00950000182824"/>
    <dbReference type="OMA" id="MEAFIKX"/>
    <dbReference type="OrthoDB" id="5981864at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035648">
        <property type="entry name" value="srGAP1/2/3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049581">
        <property type="entry name" value="SrGAP3_F-BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="15">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="14">
        <location>
            <begin position="507"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="745"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="810"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="864"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1091"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064269"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00078662"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1101" mass="124827" checksum="2F9790CDD9E4658B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8A0</accession>
    <name>A0A670I8A0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 45 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC45A3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028590178.1">
        <property type="nucleotide sequence ID" value="XM_028734345.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028590179.1">
        <property type="nucleotide sequence ID" value="XM_028734346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I8A0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008493.1">
        <property type="protein sequence ID" value="ENSPMRP00000007942.1"/>
        <property type="gene ID" value="ENSPMRG00000005368.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599314"/>
    <dbReference type="KEGG" id="pmua:114599314"/>
    <dbReference type="CTD" id="85414"/>
    <dbReference type="GeneTree" id="ENSGT00950000182914"/>
    <dbReference type="OMA" id="FQWYALF"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045723">
        <property type="term" value="P:positive regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010907">
        <property type="term" value="P:positive regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048713">
        <property type="term" value="P:regulation of oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17313">
        <property type="entry name" value="MFS_SLC45_SUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000193">
        <property type="entry name" value="Solute carrier family 45 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000230">
        <property type="entry name" value="Solute carrier family 45 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF37">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="573" mass="62850" checksum="0C3E55222E537612" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IAB7</accession>
    <name>A0A670IAB7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IAB7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009183.1">
        <property type="protein sequence ID" value="ENSPMRP00000008592.1"/>
        <property type="gene ID" value="ENSPMRG00000005806.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="WHILKEM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="653" mass="75803" checksum="CA4B88E6C15B128B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IB99</accession>
    <name>A0A670IB99_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IB99"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009561.1">
        <property type="protein sequence ID" value="ENSPMRP00000008948.1"/>
        <property type="gene ID" value="ENSPMRG00000006018.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="2">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="65" mass="7326" checksum="CD71883005C58B90" modified="2020-06-17" version="1">MLSRKQLVQAAQLAEQCGRYKDMATAMRQLVMEGKDPLTHEEKTLLSEAYNLCTVLHLPGTRPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IC58</accession>
    <name>A0A670IC58_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclic GMP-AMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CGAS</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028578599.1">
        <property type="nucleotide sequence ID" value="XM_028722766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IC58"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009922.1">
        <property type="protein sequence ID" value="ENSPMRP00000009296.1"/>
        <property type="gene ID" value="ENSPMRG00000006256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593874"/>
    <dbReference type="KEGG" id="pmua:114593874"/>
    <dbReference type="CTD" id="115004"/>
    <dbReference type="GeneTree" id="ENSGT01050000244827"/>
    <dbReference type="OMA" id="RTWCEST"/>
    <dbReference type="OrthoDB" id="6054650at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061501">
        <property type="term" value="F:2',3'-cyclic GMP-AMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160004">
        <property type="term" value="F:poly-ADP-D-ribose modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071360">
        <property type="term" value="P:cellular response to exogenous dsRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140896">
        <property type="term" value="P:cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160049">
        <property type="term" value="P:negative regulation of cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038001">
        <property type="term" value="P:paracrine signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000774">
        <property type="term" value="P:positive regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002230">
        <property type="term" value="P:positive regulation of defense response to virus by host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002637">
        <property type="term" value="P:regulation of immunoglobulin production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000007">
        <property type="entry name" value="Cyclic GMP-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF35">
        <property type="entry name" value="CYCLIC GMP-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="3">
        <location>
            <begin position="357"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="4">
        <location>
            <begin position="558"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="672" mass="73216" checksum="AC420465C5959160" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEZ0</accession>
    <name>A0A670IEZ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Envoplakin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">210 kDa cornified envelope precursor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">p210</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">May form a homodimer or a heterodimer with PPL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cornified envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the plakin or cytolinker family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000011212.1">
        <property type="protein sequence ID" value="ENSPMRP00000010510.1"/>
        <property type="gene ID" value="ENSPMRG00000006965.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153578"/>
    <dbReference type="OMA" id="TEHACGA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001533">
        <property type="term" value="C:cornified envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002786">
        <property type="term" value="P:regulation of antibacterial peptide production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000178">
        <property type="entry name" value="Envoplakin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000010">
        <property type="entry name" value="Envoplakin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.780:FF:000002">
        <property type="entry name" value="Envoplakin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000142">
        <property type="entry name" value="Envoplakin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000109">
        <property type="entry name" value="Periplakin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000088">
        <property type="entry name" value="Periplakin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000030">
        <property type="entry name" value="Short stop, isoform K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058847">
        <property type="entry name" value="Plectin_PPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055419">
        <property type="entry name" value="Spectrin_PEPL/EVPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF7">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00681">
        <property type="entry name" value="Plectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26346">
        <property type="entry name" value="Plectin_PPL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23160">
        <property type="entry name" value="Spectrin_1st_PEPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21097">
        <property type="entry name" value="SR_plectin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IGG8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011625.1">
        <property type="protein sequence ID" value="ENSPMRP00000010888.1"/>
        <property type="gene ID" value="ENSPMRG00000007242.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of smooth muscle cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Noelin_dom"/>
    </dbReference>
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        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
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        <property type="entry name" value="NOELIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Noelin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Olfactomedin-like" evidence="11">
        <location>
            <begin position="201"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="153"/>
            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="202"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="461" mass="52983" checksum="09B0EFCC6CF4D6B6" modified="2020-06-17" version="1">GWPQLEPELFRLRLQSVLYASFSLQTLFQSPDEGWQVYTSAQAPDGKCLCTAVIPVQGTCSRDLRSRQLRQLMEKVQNISQSMEVLDLRTYRDLQYVRNTESLIKGLDSRLKVATESQKNLNAKSFQELKDKMAELMPLIPVLDQYKSDTRTIMQLKEEVRNLSGSLLQIQEEMGAYDYEELQQRVLVLEARLHACMQKLGCGKLTGVSNPITIRASGSRFGSWMTDTMAPSSDSRVWYMDGYYKGRRVLEYRTLNDFITGQNFVQHLLPHPWAGTGHVVFNGSLYYNKYQSNIVVKYHFRSRSVVVQRSLNTAGYNNTFPYSWGGFSDIDFMVDENGLWAVYTTNQNAGNIVVSRMDPVTLEILRSWDTGYPKRSAGESFIICGTLYVTNSHLAGAKIYFAYYTNTSSYEYTDIPFHNQYSHISMLDYNPRERVLYTWNNGHQVIYNVTLFHVIKTSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGK5</accession>
    <name>A0A670IGK5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DnaJ homolog subfamily C member 5B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DNAJC5B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with the chaperone complex consisting of HSC70 and SGTA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IGK5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011703.1">
        <property type="protein sequence ID" value="ENSPMRP00000010958.1"/>
        <property type="gene ID" value="ENSPMRG00000007296.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dnaJ homolog subfamily C member 5"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF6">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="256" mass="28797" checksum="5F3A1B11A6B18480" modified="2020-06-17" version="1">MAEQRQRALSTSGQALYELLGLEKGASHEEIKKCYRKLALKYHPDKNPDNPEAAEKFKEINNAHAILTDGSKRNIYDQYGSLGLYIAEQFGEENVNTYFMLSSWWAKGLFAICGLLTGCYFCCCLCCCFNCCCGKCKPKAPEEDQEFCLSPEDLEEQIKTDMERGAYYYGDVDILFNNKTNKNTVIFSNTYPGVSLQLFSFGGVNLRKDTNLKEVLIEFLSTCCTGYFKCPVVCGCLLMSLLISVGVCPSFQTKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIF7</accession>
    <name>A0A670IIF7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IIF7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011886.1">
        <property type="protein sequence ID" value="ENSPMRP00000011127.1"/>
        <property type="gene ID" value="ENSPMRG00000007433.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234712"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
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</entry>
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</entry>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028574562.1">
        <property type="nucleotide sequence ID" value="XM_028718729.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574563.1">
        <property type="nucleotide sequence ID" value="XM_028718730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ILS1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013360.1">
        <property type="protein sequence ID" value="ENSPMRP00000012509.1"/>
        <property type="gene ID" value="ENSPMRG00000008377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591564"/>
    <dbReference type="KEGG" id="pmua:114591564"/>
    <dbReference type="CTD" id="118442"/>
    <dbReference type="GeneTree" id="ENSGT00950000182998"/>
    <dbReference type="OMA" id="LIWVKSL"/>
    <dbReference type="OrthoDB" id="6117944at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15220">
        <property type="entry name" value="7tmA_GPR61_GPR62-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF11">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="411" mass="45723" checksum="6A78CB1D08F61847" modified="2020-06-17" version="1">MGTMVNKTRINSTQGFDTFSSLGVSQFQEAIGIFFMVMLSVIALVANTAVMVVILKTPLLRKFIFVCHLCLVDLLSAIFVMPLGIISGSTCFNRVLYSIAECQTLIFLNVCFISASIFTISVISIERYYYIVHPMRYEVKMTTGLAVTVVAFIWVKSILVAALALVGWPQVDGASSASKCTVYWSPGAHKKIFVIIFSTLCFIVPTLIIFAVYGSIYKVARIASLQHAPVPSWTATPRPRSDSIHSQVTIITTRNAPPRLSPERLFGGNKAALTLVLIVGQFLCCWLPFFSFHLHCSINSVLTIPSYGEIIVTWLAYSSFAINPFFYGLLNRQIREELSKLGRHCLSKPLSQELCISSPEGSIHENFLQFLQRTSCTTETRSTYVNSSPRNTLDQTTMGFWIPGQIPEETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILU3</accession>
    <name>A0A670ILU3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC114602038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028595608.1">
        <property type="nucleotide sequence ID" value="XM_028739775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ILU3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013387.1">
        <property type="protein sequence ID" value="ENSPMRP00000012534.1"/>
        <property type="gene ID" value="ENSPMRG00000008399.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602038"/>
    <dbReference type="KEGG" id="pmua:114602038"/>
    <dbReference type="GeneTree" id="ENSGT00940000163363"/>
    <dbReference type="OMA" id="PESMANT"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="C-FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="259" mass="27807" checksum="3AEBA990DE8EB905" modified="2020-06-17" version="1">MSMLNARSVLVTGSNRGIGLELVKQLVEKSNRPEWIFATCRDPEGPGAQALKNLAAKHEGVVINPLDTCEPNSIKAAAARVTECLKGAGLNLLINNAGIVRPASMEDETPESMSEVYRTNVIGPMVVTQAFLPLLRKASQESPRKGMSCSKAAIVNISSDAGSITNLLGWEVGHSINYRCSKAALNMLTRCQSLGFAEDEILCVALHPGWLQTDMGNFEGILAPVKVDEGVKEILNTLACLSEKNTGTFVNLDGETLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IM09</accession>
    <name>A0A670IM09_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARF like GTPase 6 interacting protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ARL6IP6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IM09"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013587.1">
        <property type="protein sequence ID" value="ENSPMRP00000012721.1"/>
        <property type="gene ID" value="ENSPMRG00000008504.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009987"/>
    <dbReference type="OMA" id="ALTIVWC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029383">
        <property type="entry name" value="ARL6IP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28640">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28640:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15062">
        <property type="entry name" value="ARL6IP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="201" mass="21840" checksum="DCEE562972E2A8EE" modified="2020-06-17" version="1">MAVRYRNIAVRYGRAGPPGTPWPPERGEVARNLQAELEEEEEEGGGGGKGELLGGLGRSPVSRATLAPLPDGAARRWPSRAFSVLCCLLAVSLLAFLLAIACLVLRGEEKARKSQETPQCMGYRLLGFWSLLVLSLMSGLSCCSFSWTVTYFDSFEPGMFPPTPLSPARFKRMTGHSFHMGYSMAILNGIVAALALVWCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IPR3</accession>
    <name>A0A670IPR3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanylate cyclase activator 2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the guanylin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IPR3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014115.1">
        <property type="protein sequence ID" value="ENSPMRP00000013222.1"/>
        <property type="gene ID" value="ENSPMRG00000008853.1"/>
    </dbReference>
    <dbReference type="OMA" id="ACEICES"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030250">
        <property type="term" value="F:guanylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1450.10">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000879">
        <property type="entry name" value="Guanylin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036382">
        <property type="entry name" value="Guanylin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11318:SF4">
        <property type="entry name" value="GUANYLATE CYCLASE ACTIVATOR 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11318">
        <property type="entry name" value="GUANYLIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02058">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00774">
        <property type="entry name" value="GUANYLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89890">
        <property type="entry name" value="Proguanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="103" mass="10982" checksum="FB6E244DD8FFBF4F" modified="2020-06-17" version="1">RTSGLFPVLVQSSAWGVGDIAFSLESAKKLKELLGRDAGSAPLHTRSQLTFFTLCGNPELPEEFQGICKGKYAPQFSRGLVNLAVPNIALCDICANAACTSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQ45</accession>
    <name>A0A670IQ45_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cytochrome P450 2G1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114603160</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IQ45"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014752.1">
        <property type="protein sequence ID" value="ENSPMRP00000013806.1"/>
        <property type="gene ID" value="ENSPMRG00000009257.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162064"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008392">
        <property type="term" value="F:arachidonate epoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019373">
        <property type="term" value="P:epoxygenase P450 pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11026">
        <property type="entry name" value="CYP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000001">
        <property type="entry name" value="Cytochrome P450, family 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008067">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF153">
        <property type="entry name" value="CYTOCHROME P450 2G1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01684">
        <property type="entry name" value="EP450ICYP2A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025406198" evidence="16">
        <location>
            <begin position="32"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="558" mass="63971" checksum="13F6A0C5A56D34DE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRA2</accession>
    <name>A0A670IRA2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MPST</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
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    <dbReference type="GeneTree" id="ENSGT00510000046773"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="297" mass="32717" checksum="BA638C519FFEAD66" modified="2020-06-17" version="1">MSQQLLYRALVSAKWVSEAIKTPQAGLAVRLLDASWYLPKMKRNPRSEFEERHIPGASFFDIDQCSDRTSPYDHMLPGPAAFAEYVSKLGVGSDSHVVVYDASDQGSFSAPRVWWMFRAFGHDAVSVLDGGLKNWLREGHPVSSGKSRPVPAEFHASLDRSLVKAHEDVKENIEAQRFQVVDARSAGRFTGTEAEPREGIEPGHIPGSVNIPFTDFLTESGLEKSPEDIRSLFQEKKVDLSKPLVATCGSGVTACHVALGAYLCGKADVAIYDGAWVEWFMRARPEHIISEGKGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRY3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 692</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ZNF692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028575811.1">
        <property type="nucleotide sequence ID" value="XM_028719978.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575813.1">
        <property type="nucleotide sequence ID" value="XM_028719980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IRY3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014912.1">
        <property type="protein sequence ID" value="ENSPMRP00000013952.1"/>
        <property type="gene ID" value="ENSPMRG00000009345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592098"/>
    <dbReference type="KEGG" id="pmua:114592098"/>
    <dbReference type="CTD" id="55657"/>
    <dbReference type="GeneTree" id="ENSGT00940000161175"/>
    <dbReference type="OMA" id="MVWECLA"/>
    <dbReference type="OrthoDB" id="8685330at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006111">
        <property type="term" value="P:regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000511">
        <property type="entry name" value="zinc finger protein 692 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000598">
        <property type="entry name" value="zinc finger protein 692 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="534" mass="59639" checksum="22C60CC971CDDA04" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITC6</accession>
    <name>A0A670ITC6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5'-3' exonuclease PLD3</fullName>
            <ecNumber evidence="10">3.1.16.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phospholipase D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PLD3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates.</text>
            <dbReference type="EC" id="3.1.16.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Early endosome membrane</location>
            <topology evidence="9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Late endosome membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.16.1" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A670ITC6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015717.1">
        <property type="protein sequence ID" value="ENSPMRP00000014713.1"/>
        <property type="gene ID" value="ENSPMRG00000009823.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000015724.1">
        <property type="protein sequence ID" value="ENSPMRP00000014719.1"/>
        <property type="gene ID" value="ENSPMRG00000009823.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000015734.1">
        <property type="protein sequence ID" value="ENSPMRP00000014729.1"/>
        <property type="gene ID" value="ENSPMRG00000009823.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000015745.1">
        <property type="protein sequence ID" value="ENSPMRP00000014740.1"/>
        <property type="gene ID" value="ENSPMRG00000009823.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000015756.1">
        <property type="protein sequence ID" value="ENSPMRP00000014751.1"/>
        <property type="gene ID" value="ENSPMRG00000009823.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183059"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF16">
        <property type="entry name" value="5'-3' EXONUCLEASE PLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="14">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="14">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="570" mass="62879" checksum="1B7C323655395C7C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITG0</accession>
    <name>A0A670ITG0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tenascin family. Teneurin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ITG0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016493.1">
        <property type="protein sequence ID" value="ENSPMRP00000015443.1"/>
        <property type="gene ID" value="ENSPMRG00000010294.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234566"/>
    <dbReference type="OMA" id="IGEWITH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000016">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000021">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000026">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000008">
        <property type="entry name" value="teneurin-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057629">
        <property type="entry name" value="Teneurin1-4_GBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF65">
        <property type="entry name" value="TENEURIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23093">
        <property type="entry name" value="GBD_Tenm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="423" mass="45681" checksum="3171B89087465F75" modified="2020-06-17" version="1">MFSLSPAMHLFGLNWQLQQTENDTFENGKVNSDTVPTHTVSLPSGENGKLGGFAQENNTIDSGELDIGRRATQEVPPGIFWRSQVFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAKEQRNLLEAERAGRQARSVSLHEAGFIQYLDAGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGSCHCFAGFLGPDCSRAACPVLCSGNGQYSKGRCLCYSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGENCEEADCLDPACSNHGVCIHGECHCNPGWGGNNCEILKTMCPDQCSGHGTYLQESGTCTCDPNWTGPDCSNEICSVDCGTHGVCMGGTCRCEEGWTGPSCSQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIGRLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVY3</accession>
    <name>A0A670IVY3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Epiplakin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EPPK1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plakin or cytolinker family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000016367.1">
        <property type="protein sequence ID" value="ENSPMRP00000015322.1"/>
        <property type="gene ID" value="ENSPMRG00000010207.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162855"/>
    <dbReference type="OMA" id="CEAKSKG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097356">
        <property type="term" value="C:perinucleolar compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990254">
        <property type="term" value="F:keratin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045110">
        <property type="term" value="P:intermediate filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050680">
        <property type="term" value="P:negative regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061045">
        <property type="term" value="P:negative regulation of wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000001">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF21">
        <property type="entry name" value="EPIPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00681">
        <property type="entry name" value="Plectin"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="54"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2582"/>
            <end position="2618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2766"/>
            <end position="2796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3188"/>
            <end position="3221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3296"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3723"/>
            <end position="3756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3831"/>
            <end position="3850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4441"/>
            <end position="4474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4549"/>
            <end position="4587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4830"/>
            <end position="4850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4927"/>
            <end position="4965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2469"/>
            <end position="2503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2592"/>
            <end position="2615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2774"/>
            <end position="2796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3189"/>
            <end position="3203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3206"/>
            <end position="3221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3307"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3741"/>
            <end position="3756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="4459"/>
            <end position="4474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="4559"/>
            <end position="4583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="4830"/>
            <end position="4839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="4936"/>
            <end position="4949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="4951"/>
            <end position="4965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="5248" mass="589546" checksum="7AE1A2778ACD986B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IX78</accession>
    <name>A0A670IX78_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transcriptional repressor NF-X1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nuclear transcription factor, X box-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NFX1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IX78"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017510.1">
        <property type="protein sequence ID" value="ENSPMRP00000016411.1"/>
        <property type="gene ID" value="ENSPMRG00000010727.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156325"/>
    <dbReference type="OMA" id="CPHPCDS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd02643">
        <property type="entry name" value="R3H_NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16696">
        <property type="entry name" value="RING-CH-C4HC3_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000003">
        <property type="entry name" value="Transcriptional repressor NF-X1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034076">
        <property type="entry name" value="R3H_NF-X1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
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</entry>
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</entry>
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            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
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            <name>Zn(2+)</name>
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        </cofactor>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
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    </dbReference>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="23"/>
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        </location>
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        <source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="386" mass="40830" checksum="09A4EC4CB278B45F" modified="2020-06-17" version="1">MSTAGKVIKCKAAVVWEVKKPFSIVEIEVAPPKAHEVRIKILASGVCRSDDHVLSGALQVKFPIILGHEAAGVVESVGEGVTCVKPGDKVIPLFAPQCGECSTCKHPRGNLCKMGDLAASGVMPDGTSKFTYKGQQIHTFAGTSTFAEYTVVHESAVVKIDATAPPEKVCLIGCGFSTGYGAAINSAKVEPGSTCAVFGLGGVGLSTVMGCKAAGASRIIGVDINKDKFPKAKEMGATECVNPMDFKKPINEVLYGLTDGEGVDYSFEVIGRTDTMTAALASCHMNYGTSVVVGVPPSASEITFSPALIFTGRTWKGSIFGGWKSKEAVPKLVSDFMGGKFALEPLITHTLPFDKINEGFELLRSGKRFYIDQMVLWGPSESTILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1E1</accession>
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    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
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                <person name="Bunikis I."/>
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="76" mass="8316" checksum="762C29AB2F6C4267" modified="2020-06-17" version="1">ATTAAATPGDGSSSPGQPYSLTGLGRPPAPPEKELKRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGLSNITWTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">ERVV2 protein</fullName>
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    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="279" mass="31013" checksum="A4304067F68A5A15" modified="2020-06-17" version="1">MNLPDSWDPSPISQCFFRTFHTGRIDSCLQGLFWICGHRGYTWASPHSRGTCYLGLILPGVRVTQELPPGKRRNKRAKDLSELSDVAANGETYGRALFPAYGAGSNHVDILKLTDILLNFMEESNAATQSILTELTEVRQNSIQNRLALDYVLASTGGVCALIGTECCTHVTDQTLNITGHLNNIYKLTDKLRDIQHEGLSDTHFWSWLPGSTWIKQLLGNGLLILVTVVICIVFFCCMIHCFPICCQTCGSCLPILHPRSTPIYRPPASEIQSTPIEM</sequence>
</entry>
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        <submittedName>
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    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="gene ID" value="ENSPMRG00000012509.1"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Coagulation factor X (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein Z, vitamin K-dependent plasma glycoprotein"/>
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    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
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    </dbReference>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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    <dbReference type="InterPro" id="IPR050442">
        <property type="entry name" value="Peptidase_S1_coag_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278">
        <property type="entry name" value="COAGULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278:SF20">
        <property type="entry name" value="VITAMIN K-DEPENDENT PROTEIN Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="110"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="334" mass="37444" checksum="B562D410F4A89FD3" modified="2020-06-17" version="1">MHLLIIFPLPPTQDGAPCSSNPCLHNGVCKDSIRSYTCDCRDGFEGANCAFAKNECRHEINEGCQHFCYPELTSYRCSCAKAYELGQDAKSCLPQDQCACGRHKDHLPVQLDATKTIQRGFPWQVLLLNSEGEWFCGGVLLKTNFVLTTAECARLTPVIAVIGINRLQRARQEIPVKQINIHIRYDSDTGENNLALLELEQHIGCSSHHLPICIPERDFAEHVLISEREATLSGWKADGNTSTGSTAELSVSYLNGDECKQILNRTLITREFCGYSREVSGELLAGGSFSAVDYKGTWFLTGVLEPWATEATKWETLIFTKTTRYMMWFKQKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8D6</accession>
    <name>A0A670J8D6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase domain-containing 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114591647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028574780.1">
        <property type="nucleotide sequence ID" value="XM_028718947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J8D6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020710.1">
        <property type="protein sequence ID" value="ENSPMRP00000019507.1"/>
        <property type="gene ID" value="ENSPMRG00000012718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591647"/>
    <dbReference type="KEGG" id="pmua:114591647"/>
    <dbReference type="GeneTree" id="ENSGT00940000164112"/>
    <dbReference type="OMA" id="WPFHDLT"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000081">
        <property type="entry name" value="Haloacid dehalogenase like hydrolase domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF43">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00069384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="455" mass="50882" checksum="BB193C8FF905CB19" modified="2020-06-17" version="1">MRGMLLLPPLLLRRPRPPPGLRRLCSAGAASAAPAAPGKSETGSQLNIQPTFGFLFDIDGVLVRGKTPIPGARKAFQKLLNSQGEFSVPVVFVTNAGNCLRQKKADQLYHILGVPISQDQVMMSHSPLRMFRRYHDKCVLVSGQGPLLDIAKHVGFCQPITIDRLRENFPLLDMVDHDRRPKVSHPPEVELPKIEAIVLFGEPVRWETNLQLIIDVLLTSGYPGNPYAQATHPHIPVLACNMDLMWMAEAQSPRFGHGTFMVCLENIYKKITGKELKYEALMGKPSELTYHYAEYLIRTQATAKQWKKPIQTLYAIGDNLMTDIYGANLYNRYLQEKNSRRGSKARIQAKAAGGSRSATVSQEEELENTWESELAPATATSCRSVLVCTGVYSPHTEVPSDTRECITETVFHGHRDFRFDPALVEPNHIVPDVEAAVDLIFQLENFAPNENYRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J953</accession>
    <name>A0A670J953_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114582300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J953"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020957.1">
        <property type="protein sequence ID" value="ENSPMRP00000019727.1"/>
        <property type="gene ID" value="ENSPMRG00000012880.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165513"/>
    <dbReference type="OMA" id="ITLRTHF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15935">
        <property type="entry name" value="7tmA_OR4Q3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000012">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="45"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="314" mass="34957" checksum="AEEC6FE58DB4D6D7" modified="2020-06-17" version="1">MKIVHGPSIPMNISCVTEFVFLGLSNSRSIQIFLFVLVFASTLVGNLLIVVTVHAEPRLLLSPMYFFLSNLSILDTSLASVAVPKMLADLVSYGRTISYGGCMAQVFFLHFFGGSEMLLLTLMAYDRYVAICHPLRYTTTMNRQRCMRLLASCWIGGLIHSATQLILVLRLPFCGPNELDNFYCDVPQVVKLACVNTYVTEILMAANSGLLSLACFLILLISYGVILVSLQGRFKESRRKALSTCSSHLTVVSLFFVPCLFVYLVPFSSTNVDKMASTFYTVVTPALNPIIYTLRNQDMKKAMGQLKNQCIFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J9F9</accession>
    <name>A0A670J9F9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gag-Pol polyprotein</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gypsy retrotransposon integrase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670J9F9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021543.1">
        <property type="protein sequence ID" value="ENSPMRP00000020289.1"/>
        <property type="gene ID" value="ENSPMRG00000013210.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160750"/>
    <dbReference type="OMA" id="RTHWGRE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09273">
        <property type="entry name" value="RNase_HI_RT_Bel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040643">
        <property type="entry name" value="MLVIN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18697">
        <property type="entry name" value="MLVIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="15">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="16">
        <location>
            <begin position="180"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="17">
        <location>
            <begin position="613"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="878"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1140"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1183"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1236" mass="137423" checksum="953FB8B321467E83" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JD31</accession>
    <name>A0A670JD31_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JD31"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023468.1">
        <property type="protein sequence ID" value="ENSPMRP00000022095.1"/>
        <property type="gene ID" value="ENSPMRG00000014375.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162430"/>
    <dbReference type="OMA" id="LIPMATC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007340">
        <property type="term" value="P:acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF8">
        <property type="entry name" value="ACROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="226" mass="24468" checksum="2CB3E623C07D66B4" modified="2020-06-17" version="1">GNPTLELLDVVLKRRGAQLTPCGVCGRRPMAGSHNLLRVVGSSNASPGTWPWMVSFQIKTFRGYFSFCGGSLISPRWVLSAAHCFQKHFLNDTYRKVHNDISLVELNEPVNCTDYIQPACLPDDSVVVSLLKHCYVSGFGIIDPKSEICRETRPPEGAGTVDLIPMATCSSPDWWSNRILEENICAGTLEGGVASCKVVKLQQNQGYGFGLGAKLSSAPGAAEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JDL4</accession>
    <name>A0A670JDL4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pleckstrin homology and RUN domain containing M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PLEKHM1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JDL4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024029.1">
        <property type="protein sequence ID" value="ENSPMRP00000022613.1"/>
        <property type="gene ID" value="ENSPMRG00000014654.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155111"/>
    <dbReference type="OMA" id="IWRDYYC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044754">
        <property type="term" value="C:autolysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902774">
        <property type="term" value="P:late endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13321">
        <property type="entry name" value="PH_PLEKHM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17679">
        <property type="entry name" value="RUN_PLEKHM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042827">
        <property type="entry name" value="PLEKHM1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047326">
        <property type="entry name" value="RUN_PLEKHM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="13">
        <location>
            <begin position="39"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="512"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="650"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="356"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1025" mass="112428" checksum="F37640F63970BB59" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEB7</accession>
    <name>A0A670JEB7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SMAD6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028705531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JEB7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023899.1">
        <property type="protein sequence ID" value="ENSPMRP00000022495.1"/>
        <property type="gene ID" value="ENSPMRG00000014612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584065"/>
    <dbReference type="KEGG" id="pmua:114584065"/>
    <dbReference type="CTD" id="4091"/>
    <dbReference type="GeneTree" id="ENSGT00940000158146"/>
    <dbReference type="OMA" id="LLVCKVY"/>
    <dbReference type="OrthoDB" id="5946219at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070410">
        <property type="term" value="F:co-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070412">
        <property type="term" value="F:R-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070698">
        <property type="term" value="F:type I activin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:type I transforming growth factor beta receptor binding"/>
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        <property type="term" value="F:ubiquitin protein ligase binding"/>
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    <dbReference type="GO" id="GO:0035904">
        <property type="term" value="P:aorta development"/>
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    <dbReference type="GO" id="GO:0003180">
        <property type="term" value="P:aortic valve morphogenesis"/>
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        <property type="term" value="P:BMP signaling pathway"/>
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        <property type="term" value="P:cell-substrate adhesion"/>
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    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
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    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0003183">
        <property type="term" value="P:mitral valve morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032926">
        <property type="term" value="P:negative regulation of activin receptor signaling pathway"/>
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        <property type="term" value="P:response to laminar fluid shear stress"/>
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    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
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        <property type="term" value="P:ureteric bud development"/>
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        <property type="term" value="P:ventricular septum development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:zygotic specification of dorsal/ventral axis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="MH1_SMAD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MH2_SMAD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
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        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
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    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
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    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
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        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="9">
        <location>
            <begin position="159"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="10">
        <location>
            <begin position="338"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="504" mass="55047" checksum="0229E9313121C08F" modified="2020-06-17" version="1">MFRSKRAGLVRRLWRSRVLPDREGVGGGGGGGDGGGGGSTGSSTGSLRKSHERGGSDGRSPEKPPASGRRAVTGGGAVEEPCALERSMAHGEGDPPAPPEVEEEAAAVAAAAAREDAEDGGSDGGLERDSPWWAQESDGMTVTCCLFKERDADADAVSPRPRELPAREGRSRLTLLEQELKAVTYSLLKRLKERSLDSLLEAVESRGGMPSDCVLVSRAEVRLGGQAAPPHLLLGKLFRWPDLQHPAELKPLCECGSFGLPDGPTVCCNPYHFSRLCGPESPPPPYSRLSPNDEQKPLDLSDSTLSYTETEATNSPNVTPGEFSDASMSPDAIKQSHWCNVAYWEHRTRVGRLYTVYEQSVSIFYDLPQGNGFCLGQLQLENRNETVRRTRSKIGYGILLSKEQDGVWAYNRSEHPIFINSPTLDIPNCRTLIVRKVMPGYSIKVFDYEKSCLLQHATDLGYPDGPFDPNSVRISFAKGWGPSYSRQFITSCPCWLEILLNNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEK4</accession>
    <name>A0A670JEK4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EFTUD2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JEK4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024426.1">
        <property type="protein sequence ID" value="ENSPMRP00000022998.1"/>
        <property type="gene ID" value="ENSPMRG00000014919.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155685"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000574">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
    <sequence length="182" mass="20187" checksum="47177004AB552A9C" modified="2020-06-17" version="1">SILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGVGRDPSLSALIYKDEKLTVNQDLPVHDGKPHIVHFQYKVTEVKVSSWDAVLSNQSLFVEIPDGVLADGSKEGLLALLEFAEEKMKASYVFICFRKSREDRAALLKTFSFLGFEIVRPGHPCVPSRPDVLFMVYPLDQVSSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JGI6</accession>
    <name>A0A670JGI6_PODMU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="13" type="primary">LOC114590722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
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        <location>
            <position position="465"/>
        </location>
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            <name>heme</name>
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        </ligand>
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        </ligandPart>
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        <source>
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    </evidence>
    <sequence length="524" mass="58737" checksum="9F580D40CD466C90" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJ13</accession>
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        </submittedName>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="entry name" value="Tudor"/>
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    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JM75"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027076.1">
        <property type="protein sequence ID" value="ENSPMRP00000025506.1"/>
        <property type="gene ID" value="ENSPMRG00000016520.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159592"/>
    <dbReference type="OMA" id="APLAKCE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045791">
        <property type="entry name" value="Sema4F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF72">
        <property type="entry name" value="SEMAPHORIN-4F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19428">
        <property type="entry name" value="Sema4F_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="8">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="619" mass="68720" checksum="F53DC74E6E0CEBEB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JN34</accession>
    <name>A0A670JN34_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JN34"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028073.1">
        <property type="protein sequence ID" value="ENSPMRP00000026463.1"/>
        <property type="gene ID" value="ENSPMRG00000017112.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="VMKMAIL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="696" mass="82508" checksum="41C4DD5D8CEE70AB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPC3</accession>
    <name>A0A670JPC3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Whirlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">WHRN</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms homooligomers. Interacts (via C-terminal PDZ domain) with MYO15A; this interaction is necessary for localization of WHRN to stereocilia tips. Interacts (via C-terminal PDZ domain) with MPP1/p55. Interacts with LRRC4C/NGL1. Interacts with MYO7A. Interacts with RPGR. Interacts with EPS8. Interacts with CASK. Interacts with CIB2. Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN. Interacts (via PDZ domains) with PDZD7; the interaction is direct. Interacts (via N-terminal PDZ domain) with USH2A (via cytoplasmic region). Interacts with ADGRV1/MASS1 (via cytoplasmic region).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Stereocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028571187.1">
        <property type="nucleotide sequence ID" value="XM_028715354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JPC3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027880.1">
        <property type="protein sequence ID" value="ENSPMRP00000026276.1"/>
        <property type="gene ID" value="ENSPMRG00000017001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589182"/>
    <dbReference type="CTD" id="25861"/>
    <dbReference type="GeneTree" id="ENSGT00950000183002"/>
    <dbReference type="OMA" id="TMVNQTR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990075">
        <property type="term" value="C:periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990696">
        <property type="term" value="C:USH2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021694">
        <property type="term" value="P:cerebellar Purkinje cell layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050910">
        <property type="term" value="P:detection of mechanical stimulus involved in sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990227">
        <property type="term" value="P:paranodal junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001895">
        <property type="term" value="P:retina homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050953">
        <property type="term" value="P:sensory perception of light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07356">
        <property type="entry name" value="HN_L-whirlin_R1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07357">
        <property type="entry name" value="HN_L-whirlin_R2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06740">
        <property type="entry name" value="PDZ1_FL-whirlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06741">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="597" mass="67053" checksum="B43F857E219B2672" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JR47</accession>
    <name>A0A670JR47_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Guanylate cyclase</fullName>
            <ecNumber evidence="19">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">NPR2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A670JR47"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028523.1">
        <property type="protein sequence ID" value="ENSPMRP00000026886.1"/>
        <property type="gene ID" value="ENSPMRG00000016990.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156985"/>
    <dbReference type="OMA" id="SEMDGAC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016941">
        <property type="term" value="F:natriuretic peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060466">
        <property type="term" value="P:activation of meiosis involved in egg activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060385">
        <property type="term" value="P:axonogenesis involved in innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008015">
        <property type="term" value="P:blood circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001974">
        <property type="term" value="P:blood vessel remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061939">
        <property type="term" value="P:c-di-GMP signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071321">
        <property type="term" value="P:cellular response to cGMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097011">
        <property type="term" value="P:cellular response to granulocyte macrophage colony-stimulating factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901653">
        <property type="term" value="P:cellular response to peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035988">
        <property type="term" value="P:chondrocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048668">
        <property type="term" value="P:collateral sprouting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048546">
        <property type="term" value="P:digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097194">
        <property type="term" value="P:execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030540">
        <property type="term" value="P:female genitalia development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035483">
        <property type="term" value="P:gastric emptying"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035112">
        <property type="term" value="P:genitalia morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003417">
        <property type="term" value="P:growth plate cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035108">
        <property type="term" value="P:limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001945">
        <property type="term" value="P:lymph vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903537">
        <property type="term" value="P:meiotic cell cycle process involved in oocyte maturation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051447">
        <property type="term" value="P:negative regulation of meiotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900194">
        <property type="term" value="P:negative regulation of oocyte maturation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036342">
        <property type="term" value="P:post-anal tail morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071774">
        <property type="term" value="P:response to fibroblast growth factor"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034699">
        <property type="term" value="P:response to luteinizing hormone"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902074">
        <property type="term" value="P:response to salt"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048745">
        <property type="term" value="P:smooth muscle tissue development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001964">
        <property type="term" value="P:startle response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061042">
        <property type="term" value="P:vascular wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021647">
        <property type="term" value="P:vestibulocochlear nerve maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050872">
        <property type="term" value="P:white fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14042">
        <property type="entry name" value="PK_GC-A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001106">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000101">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
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    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00458">
        <property type="entry name" value="ANF_RECEPTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 19" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="15 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025517443" description="Guanylate cyclase" evidence="22">
        <location>
            <begin position="25"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="529"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="24">
        <location>
            <begin position="879"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120829" checksum="92F954EC6BDFFB2E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JR79</accession>
    <name>A0A670JR79_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Crk-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CRKL</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May mediate the transduction of intracellular signals.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028565242.1">
        <property type="nucleotide sequence ID" value="XM_028709409.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000029210.1">
        <property type="protein sequence ID" value="ENSPMRP00000027543.1"/>
        <property type="gene ID" value="ENSPMRG00000017773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586239"/>
    <dbReference type="KEGG" id="pmua:114586239"/>
    <dbReference type="CTD" id="1399"/>
    <dbReference type="GeneTree" id="ENSGT00820000127055"/>
    <dbReference type="OMA" id="WYVGPLS"/>
    <dbReference type="OrthoDB" id="9204160at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060392">
        <property type="term" value="P:negative regulation of SMAD protein signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903977">
        <property type="term" value="P:positive regulation of glial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09926">
        <property type="entry name" value="SH2_CRK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11758">
        <property type="entry name" value="SH3_CRK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000065">
        <property type="entry name" value="adapter molecule crk isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000026">
        <property type="entry name" value="adapter molecule crk isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000163">
        <property type="entry name" value="crk-like protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035457">
        <property type="entry name" value="CRK_SH3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="131"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="242"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="310" mass="34161" checksum="7B9827BB7EFC8C18" modified="2020-06-17" version="1">MSSSSSSVASAARFDPSDRSSWYAGPLSRQEAQGRLQGQRHGTFLVRDSATCPGDYVLSVSENSRVSHYIINSLPGRRFKIGDQEFEHLPALLDFYKIHYLDTTTLIEPAPRYPAALMGSGSAPIMTAAEDNVEYVRTLYDFAGNDAEDLPFKKGEILVIVEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGNRNRNSNSYGIPEPAHAYAQPQTASPLPNIANTPGAVITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVHGRKGLFPFTHVKIIDPQNPDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSM0</accession>
    <name>A0A670JSM0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WAS/WASL interacting protein family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">WIPF2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028559266.1">
        <property type="nucleotide sequence ID" value="XM_028703433.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559267.1">
        <property type="nucleotide sequence ID" value="XM_028703434.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559268.1">
        <property type="nucleotide sequence ID" value="XM_028703435.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559269.1">
        <property type="nucleotide sequence ID" value="XM_028703436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JSM0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027532.1">
        <property type="protein sequence ID" value="ENSPMRP00000025942.1"/>
        <property type="gene ID" value="ENSPMRG00000016795.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582416"/>
    <dbReference type="KEGG" id="pmua:114582416"/>
    <dbReference type="CTD" id="147179"/>
    <dbReference type="GeneTree" id="ENSGT00940000155557"/>
    <dbReference type="OMA" id="QWQHNAT"/>
    <dbReference type="OrthoDB" id="5877983at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22077">
        <property type="entry name" value="WH2_WAS_WASL-2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="440" mass="46204" checksum="6A3F0425AEEC8100" modified="2020-06-17" version="1">MPIPPPPPPGPPPPPTFNQANTDAPKLNRDEQRGRGALLQDICKGAKLKKVTQVNDRSAPVIEKSKGSGGYNSGASPLPPKGGLFQGGVPKLRPVGVKDSSESPSGKQCLQVPGSRSAAPRPPVSATSNRPQDDADNSRASPPELPRMQRPSLPDLSRPNTASGTGMKHSSSAPPPPPPGRRANAPPAPPPMHSSKAPSYNREKPLPPTPGQRLPGTRDGPPAPPPIKPPPSPVNIRTGPSSQGQSLAPPPPPYRQPPGVPNGPASPTNESAPELPQRHNSLHRKTPGPGRGMAPPPPPSASPSLQSSRPPPPARDPPSRGAAPPPPPPMIRNGGRDAPPPPPPYRMHGTSDPTSRGKPPPPPTRTPVGPPPPPPPMRNGHRDSISTVRSFLGDDFESKYSFHPVEDFPAPEEFKHFQKIYPSKTNRATRGAPPLPPIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JU53</accession>
    <name>A0A670JU53_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="4 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NTAQ1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NTAQ1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="4 8"/>
    <dbReference type="AlphaFoldDB" id="A0A670JU53"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029701.1">
        <property type="protein sequence ID" value="ENSPMRP00000028001.1"/>
        <property type="gene ID" value="ENSPMRG00000018074.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014398"/>
    <dbReference type="OMA" id="GWGTVYS"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.10:FF:000001">
        <property type="entry name" value="Blast:Protein N-terminal glutamine amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="9">
        <location>
            <begin position="31"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="212" mass="23981" checksum="CC9AEFE2C52A1412" modified="2020-06-17" version="1">MDQAEPGLADAAAAAPAGYEPAVPARPGCVYTGCYCEENVWKLCEYIRNQNLYPLEEFYAVFISNDRRMVPLWEQQAGMVGQPVIWDYHVVLLHVVSGDQNFIYDLDTLLPFPCPIDTYIEKAFKSDSVIHPEFQRKVRLVQADVYLKTFASDRSHMKDASGNWQKPPPLYPCIETADFKMNLDDFISMNPDVGWGSVLSLPEFVQGFGSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JU66</accession>
    <name>A0A670JU66_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DDX55</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with 28S rRNA. Interacts with double-stranded RNA substrates in vitro; the interaction stimulates ATPase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028567028.1">
        <property type="nucleotide sequence ID" value="XM_028711195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JU66"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029711.1">
        <property type="protein sequence ID" value="ENSPMRP00000028011.1"/>
        <property type="gene ID" value="ENSPMRG00000018079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587190"/>
    <dbReference type="KEGG" id="pmua:114587190"/>
    <dbReference type="CTD" id="57696"/>
    <dbReference type="GeneTree" id="ENSGT00550000074969"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000877">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001022">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="40"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="254"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="503"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="591" mass="67346" checksum="6DF06F1AC30D4C02" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JV92</accession>
    <name>A0A670JV92_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="145" mass="16323" checksum="5030489AC0E0AAF0" modified="2020-06-17" version="1">MTITWTCFRFLPREFGNICSQLNAQIKDPGTISQDTCPAQICYFSPSPPPPFLPPSIGILYLLEHGEEYVFTLPCAYARSILNGVPWVELGGKVSILCAKSGYSLQSHSTQAFLWGKSTQVRKLLFRQLLFFFSKDCSVGEKIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXP6</accession>
    <name>A0A670JXP6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KLC2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JXP6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029200.1">
        <property type="protein sequence ID" value="ENSPMRP00000027532.1"/>
        <property type="gene ID" value="ENSPMRG00000017704.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161973"/>
    <dbReference type="OMA" id="DAECLYK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="kinesin light chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015792">
        <property type="entry name" value="Kinesin_light_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF2">
        <property type="entry name" value="KINESIN LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01160">
        <property type="entry name" value="KINESIN_LIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="648" mass="72591" checksum="8C151264F8276952" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JY89</accession>
    <name>A0A670JY89_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PDK4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028605667.1">
        <property type="nucleotide sequence ID" value="XM_028749834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JY89"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029428.1">
        <property type="protein sequence ID" value="ENSPMRP00000027742.1"/>
        <property type="gene ID" value="ENSPMRG00000017905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607069"/>
    <dbReference type="KEGG" id="pmua:114607069"/>
    <dbReference type="CTD" id="5166"/>
    <dbReference type="GeneTree" id="ENSGT01030000234646"/>
    <dbReference type="OMA" id="HQENCPS"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071398">
        <property type="term" value="P:cellular response to fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000811">
        <property type="term" value="P:negative regulation of anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072593">
        <property type="term" value="P:reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045124">
        <property type="term" value="P:regulation of bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042304">
        <property type="term" value="P:regulation of fatty acid biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046320">
        <property type="term" value="P:regulation of fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010510">
        <property type="term" value="P:regulation of pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000001">
        <property type="entry name" value="[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF22">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="246"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="412" mass="46500" checksum="3CC152B080D522B7" modified="2020-06-17" version="1">MKAARIAIRSAAPLAVGERAPREVEHFARYSPSPLSIKQFLDFGSTNACEKTSFSFLRHELPVRLANILKEIDFLPSRLLSTPSVQLVKSWYVESLMELVEFHDKKSDDHKVLSNFIDAIVKVRNRHHDVVPTMAQGVLEYRDSSKMDPFINQNIQYFLDRFYMNRISIRMLINQHTLIFDNNNNVGNPKHIGCIDPCCDVVDLVHDAFQSAQMLCDQYYFASPDLKLTQVNGKAAGQPIHIVYVPSHLFHMLFELFKNAMRATVEHQENKPSLDPVEVTVVLGKEDLSIKISDRGGGVPVRKIESLFSYTYSTAPKPVMEKNSTPLAGFGYGLPISRLYAKYFHGDLHLCSISGYGTDALIYLKALSTDSVEKLPVFNKSVSKHYQTTIEADDWCVPSKEPKNVSRQTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3A2</accession>
    <name>A0A670K3A2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centromere protein M</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CENPM</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028602596.1">
        <property type="nucleotide sequence ID" value="XM_028746763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K3A2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033155.1">
        <property type="protein sequence ID" value="ENSPMRP00000031256.1"/>
        <property type="gene ID" value="ENSPMRG00000020262.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000033160.1">
        <property type="protein sequence ID" value="ENSPMRP00000031261.1"/>
        <property type="gene ID" value="ENSPMRG00000020262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605451"/>
    <dbReference type="CTD" id="79019"/>
    <dbReference type="GeneTree" id="ENSGT00390000017504"/>
    <dbReference type="OMA" id="CTLPLDI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Centromere_Cenp-M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34436">
        <property type="entry name" value="CENTROMERE PROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34436:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11111">
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="182" mass="20288" checksum="9D574BB88EB4AFFB" modified="2020-06-17" version="1">MAALAAFAKLPAINSATVLLVGTNEDFQEQLAETMLKEKEDFKVNIHLTRSLPLPAERDHIRPRIDLIVFMINVKSKYSFKDIESSLLHVDANFFLGKVCFLVIGACEMNQISVDVDTVLKLADCYCSPVLFCELERESTRISTARQLLRMLQICAGHVSGVSALSFSSLMGSYIDYSSIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K436</accession>
    <name>A0A670K436_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 14 open reading frame 119</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">C14orf119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028019">
        <property type="entry name" value="DUF4508"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16260:SF3">
        <property type="entry name" value="CHROMOSOME 14 OPEN READING FRAME 119-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16260">
        <property type="entry name" value="SIMILAR TO 1700123O20RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14969">
        <property type="entry name" value="DUF4508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="134" mass="15226" checksum="5F8B335BFB379975" modified="2020-06-17" version="1">RPLAKAPSLLPRLHNSPCLMSEPLPLSYVTAQEMRCLLHWLSGWAPAQREQFLRDLVDKAVPWKVLPLLEGLAGLSVGPGKPPSIFECQMRLWDQWFRSWSEAERNEFVRQLEEAVPDLASRFYQEVAATAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4L4</accession>
    <name>A0A670K4L4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K4L4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033663.1">
        <property type="protein sequence ID" value="ENSPMRP00000031736.1"/>
        <property type="gene ID" value="ENSPMRG00000020563.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF30">
        <property type="entry name" value="RING FINGER PROTEIN 223-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="182" mass="20441" checksum="518C9ED4531FC95D" modified="2020-06-17" version="1">MAGRDIQMQGCPICYLSFDDVFRAPRLLPCSHTFCLECLARLCVFLKSSQSFQCPLCRGSVPLPCGGAPRLPVNMDIVQQFPPWMREVQEVWLDGFRLCWRRKLPGNAKEEEAFAVLVTLELLKAAAPRGSDPRELVVAHPVSRCWETCCLLWDHYPGLFCATALMVLGLLLSTALMLGLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K697</accession>
    <name>A0A670K697_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NUDCD1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="2">Cytoplasm</location>
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            <location evidence="1">Nucleus</location>
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    </comment>
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        <source>
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        <source>
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    </evidence>
    <sequence length="586" mass="66584" checksum="25EDD7A1688B832D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7F1</accession>
    <name>A0A670K7F1_PODMU</name>
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        <recommendedName>
            <fullName evidence="4 14">Histone acetyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">KAT2B</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
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            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4 14"/>
    <dbReference type="AlphaFoldDB" id="A0A670K7F1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034166.1">
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043992">
        <property type="term" value="F:histone H3K9 acetyltransferase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004468">
        <property type="term" value="F:L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone acetyltransferase KAT2B"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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        <property type="entry name" value="Bromodomain-like_sf"/>
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        <property type="entry name" value="GNAT_dom"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT2B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Acetyltransf_1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone_acetylase_PCAF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BROMODOMAIN"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="12 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 17" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="506"/>
            <end position="654"/>
        </location>
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        <location>
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            <end position="813"/>
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        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="18">
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="707"/>
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        <location>
            <begin position="24"/>
            <end position="38"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
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            <begin position="717"/>
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            <position position="573"/>
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        <location>
            <begin position="577"/>
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        <ligand>
            <name>acetyl-CoA</name>
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        <location>
            <begin position="584"/>
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        <ligand>
            <name>acetyl-CoA</name>
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        <ligand>
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        <source>
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    <sequence length="835" mass="93086" checksum="1A26DAF1F309DAA4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="19">Nucleotide binding oligomerization domain containing 1</fullName>
        </submittedName>
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        <name evidence="19" type="primary">NOD1</name>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="16">Belongs to the NOD1-NOD2 family.</text>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
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            <end position="97"/>
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            <end position="340"/>
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        <source>
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    <evidence type="ECO:0000256" key="7">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038296"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="951" mass="108609" checksum="41428E0F7BFCE729" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9A9</accession>
    <name>A0A670K9A9_PODMU</name>
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        <recommendedName>
            <fullName evidence="11">Rho guanine nucleotide exchange factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ARHGEF11</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.</text>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005654">
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    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005085">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007186">
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    <dbReference type="GO" id="GO:0045893">
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    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1610" mass="177274" checksum="26CBF44FD931662D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAV4</accession>
    <name>A0A670KAV4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Long-chain-fatty-acid--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC27A6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KAV4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036741.1">
        <property type="protein sequence ID" value="ENSPMRP00000034638.1"/>
        <property type="gene ID" value="ENSPMRG00000022451.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159700"/>
    <dbReference type="OMA" id="PFFINIS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF10">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="91"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="372" mass="41549" checksum="56F4D95F2441C980" modified="2020-06-17" version="1">SPLPWPGGGGRRALVWSLEKRLSSPRLMFPSWATAVAAGLVSLHFLQKLFFPYFWADLKYLLKVARYGLRVEVYRLRGSVSTALERFGALARRQPDKPFLIYEEQVHTYRQVDRRSNRVARLFLEEGALARGDTVALLMSNEPDFIHAWFGLAKLGCVVAFLNCNVRARSLLHCIASCAPKMLVVGADMLGTLEEILPSLQEDIRIWVMAKESTLPHVDTVLDKLEVASDDPVPANLCVAKNLKDPHLYIFTSGTTGLPKAAIISHLQVLKGAAGLWAFGATPDDIIYITLPLYHSAAALLGIGGCIELGATCVLRKKFSASQFWTDCKKYNITVIQYIGELCRYLCKQPVVSPIKIIHLYKKWVLQEFQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBT3</accession>
    <name>A0A670KBT3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ANO10</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605548.1">
        <property type="nucleotide sequence ID" value="XM_028749715.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028605549.1">
        <property type="nucleotide sequence ID" value="XM_028749716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KBT3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035867.1">
        <property type="protein sequence ID" value="ENSPMRP00000033815.1"/>
        <property type="gene ID" value="ENSPMRG00000021930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607023"/>
    <dbReference type="KEGG" id="pmua:114607023"/>
    <dbReference type="CTD" id="55129"/>
    <dbReference type="GeneTree" id="ENSGT00940000157537"/>
    <dbReference type="OMA" id="YENHRTA"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF40">
        <property type="entry name" value="ANOCTAMIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="199"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="651" mass="75436" checksum="40A7FA7E5055911B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KC49</accession>
    <name>A0A670KC49_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">GRIK4</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15 20">Postsynaptic cell membrane</location>
            <topology evidence="15 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Presynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028708037.1"/>
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    <dbReference type="Ensembl" id="ENSPMRT00000037163.1">
        <property type="protein sequence ID" value="ENSPMRP00000035048.1"/>
        <property type="gene ID" value="ENSPMRG00000022683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585403"/>
    <dbReference type="KEGG" id="pmua:114585403"/>
    <dbReference type="CTD" id="2900"/>
    <dbReference type="GeneTree" id="ENSGT00940000159111"/>
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        <property type="component" value="Chromosome 15"/>
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        <property type="term" value="C:kainate selective glutamate receptor complex"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099507">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13724">
        <property type="entry name" value="PBP2_iGluR_kainate_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
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        <property type="entry name" value="glutamate receptor ionotropic, kainate 4"/>
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        <property type="entry name" value="Glutamate receptor, ionotropic, kainate 4"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Glu/Gly-bd"/>
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        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
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        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13 20" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
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    <keyword evidence="9 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 20" id="KW-0732">Signal</keyword>
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    <keyword evidence="5 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 20" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5027132942" description="Glutamate receptor" evidence="20">
        <location>
            <begin position="21"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="22">
        <location>
            <begin position="417"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="23">
        <location>
            <begin position="427"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="933"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="723"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="18">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="735"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="959" mass="107623" checksum="578748DD96269292" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCP6</accession>
    <name>A0A670KCP6_PODMU</name>
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        <recommendedName>
            <fullName evidence="3">RUN and TBC1 domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SGSM3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small G protein signaling modulator family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A670KCP6"/>
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        <property type="component" value="Chromosome 10"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048227">
        <property type="term" value="P:plasma membrane to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032486">
        <property type="term" value="P:Rap protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="RUN_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000012">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000013">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000115">
        <property type="entry name" value="Small G protein signaling modulator 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
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        <property type="entry name" value="Rab_GAP_TBC_domain"/>
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    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
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    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035833">
        <property type="entry name" value="SGSM3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="115"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="481"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="7">
        <location>
            <begin position="556"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="749" mass="85721" checksum="11755A04D7D00806" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCZ9</accession>
    <name>A0A670KCZ9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21 25">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="7 25">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC114596125</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 25">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 25">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="7 25"/>
    <dbReference type="RefSeq" id="XP_028583116.1">
        <property type="nucleotide sequence ID" value="XM_028727283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KCZ9"/>
    <dbReference type="SMR" id="A0A670KCZ9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036330.1">
        <property type="protein sequence ID" value="ENSPMRP00000034240.1"/>
        <property type="gene ID" value="ENSPMRG00000022227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596125"/>
    <dbReference type="KEGG" id="pmua:114596125"/>
    <dbReference type="GeneTree" id="ENSGT00510000047027"/>
    <dbReference type="OMA" id="TANSPCE"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000014">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 25" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17 24 25" id="KW-0129">CBS domain</keyword>
    <keyword evidence="18 25" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="19 25" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 25" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CBS" evidence="26">
        <location>
            <begin position="414"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="571" mass="63008" checksum="E3469E0538D05464" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDD8</accession>
    <name>A0A670KDD8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="3">2.7.7.49</ecNumber>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="3"/>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035684.1">
        <property type="protein sequence ID" value="ENSPMRP00000033634.1"/>
        <property type="gene ID" value="ENSPMRG00000021800.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240511"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000003">
        <property type="entry name" value="Transposon Tf2-6 polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="13">
        <location>
            <begin position="600"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="14">
        <location>
            <begin position="1144"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1267"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1268"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1292"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1301" mass="147551" checksum="0E639FA95B5E21DE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEN2</accession>
    <name>A0A670KEN2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Thimet oligopeptidase</fullName>
            <ecNumber evidence="13">3.4.24.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">THOP1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.</text>
            <dbReference type="EC" id="3.4.24.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.15" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028569430.1">
        <property type="nucleotide sequence ID" value="XM_028713597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KEN2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035291.1">
        <property type="protein sequence ID" value="ENSPMRP00000033267.1"/>
        <property type="gene ID" value="ENSPMRG00000021571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588367"/>
    <dbReference type="KEGG" id="pmua:114588367"/>
    <dbReference type="CTD" id="7064"/>
    <dbReference type="GeneTree" id="ENSGT00950000183171"/>
    <dbReference type="OMA" id="KNFQSAM"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF50">
        <property type="entry name" value="THIMET OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="18">
        <location>
            <begin position="306"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="767" mass="86171" checksum="76617F6349DA85EA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFW7</accession>
    <name>A0A670KFW7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KFW7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037308.1">
        <property type="protein sequence ID" value="ENSPMRP00000035185.1"/>
        <property type="gene ID" value="ENSPMRG00000022773.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159211"/>
    <dbReference type="OMA" id="RITAWPK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000002">
        <property type="entry name" value="Collagen XI alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025446847" description="Fibrillar collagen NC1 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="7">
        <location>
            <begin position="147"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="376" mass="40638" checksum="32236D7E211B57C6" modified="2020-06-17" version="1">MVWCYLFIVCSSFFLKGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGGSGPKGEQGITGPSGPIGPPGPPGLPVPPVKPCHSTSPLPQGPPGEVIQPLPIQSSKRTRRNIDASQLVNEGNADNYMDYADGMEEIFGSLNSLKLEIEQMKHPLGTQHNPARTCKDLQLCHPDFPDGEYWVDPNQGCSRDSFKVYCNFTAGGETCIFPDKKSEGARITTWPKENPGSWFSEFKRGKLLSYVDSDGNPIGVVQMTFLRLLSASAHQNLTYNCFQSVAWHDATAGNYDKAIRFLGSNDEEMSYDNNPFIRAVLDGCAAKKGYQKTVLEINTPKVEQVPIVDIMFNDFGEASQKFGFEVGPACFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFX2</accession>
    <name>A0A670KFX2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Non-POU domain-containing octamer-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">NONO</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="26">Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits. NONO is a component of spliceosome and U5.4/6 snRNP complexes. Interacts with CPNE4 (via VWFA domain). Forms heterodimers with PSPC1; this involves formation of a coiled coil domain by helices from both proteins. Part of complex consisting of SFPQ, NONO and MATR3. Part of a complex consisting of SFPQ, NONO and NR5A1. Part of a complex consisting of SFPQ, NONO and TOP1. Interacts with SPI1 and SPIB. Interacts with RNF43. Interacts with PER1 and PER2. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA. Interacts (via second RRM domain) with WASL; the interaction is direct. Component of a multiprotein complex with WASL and SFPQ. Interacts with ERCC6. Interacts (via DNA-binding domain) with TET1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028570897.1">
        <property type="nucleotide sequence ID" value="XM_028715064.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028570898.1">
        <property type="nucleotide sequence ID" value="XM_028715065.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028570899.1">
        <property type="nucleotide sequence ID" value="XM_028715066.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028570900.1">
        <property type="nucleotide sequence ID" value="XM_028715067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KFX2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037313.1">
        <property type="protein sequence ID" value="ENSPMRP00000035190.1"/>
        <property type="gene ID" value="ENSPMRG00000022777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589063"/>
    <dbReference type="CTD" id="4841"/>
    <dbReference type="GeneTree" id="ENSGT00940000154442"/>
    <dbReference type="OMA" id="MGGNPPG"/>
    <dbReference type="OrthoDB" id="10067824at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042382">
        <property type="term" value="C:paraspeckles"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903377">
        <property type="term" value="P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12946">
        <property type="entry name" value="NOPS_p54nrb_PSF_PSPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12588">
        <property type="entry name" value="RRM1_p54nrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12591">
        <property type="entry name" value="RRM2_p54nrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000226">
        <property type="entry name" value="Non-POU domain-containing octamer-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000043">
        <property type="entry name" value="paraspeckle component 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012975">
        <property type="entry name" value="NOPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034552">
        <property type="entry name" value="p54nrb_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034558">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KHS9</accession>
    <name>A0A670KHS9_PODMU</name>
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        <submittedName>
            <fullName evidence="6">Calcium and integrin binding 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CIB1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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</entry>
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                <person name="Wallerman O."/>
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                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Salvi D."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        </subcellularLocation>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="KEGG" id="pmua:114592993"/>
    <dbReference type="GeneTree" id="ENSGT00940000155862"/>
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    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cornified envelope"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:keratinization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF_conserved"/>
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    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF69">
        <property type="entry name" value="IF ROD DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
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    </dbReference>
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        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="153"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="366"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="565" mass="60440" checksum="80A581E563CDBD3D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKH8</accession>
    <name>A0A670KKH8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Paralemmin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Paralemmin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Interacts with dopamine receptor DRD3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Apicolateral cell membrane</location>
            <topology evidence="18">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Basolateral cell membrane</location>
            <topology evidence="19">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Filopodium membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the paralemmin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KKH8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038438.1">
        <property type="protein sequence ID" value="ENSPMRP00000036274.1"/>
        <property type="gene ID" value="ENSPMRG00000023426.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160580"/>
    <dbReference type="OMA" id="CLCLHEK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016327">
        <property type="term" value="C:apicolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031527">
        <property type="term" value="C:filopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004965">
        <property type="entry name" value="Paralemmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10498:SF6">
        <property type="entry name" value="PARALEMMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10498">
        <property type="entry name" value="PARALEMMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03285">
        <property type="entry name" value="Paralemmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0636">Prenylation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="296"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00041963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="356" mass="38815" checksum="0B0EB9BA4432DFA8" modified="2020-06-17" version="1">MCVRPIERMQAEKRKRQAEIENKRRQLEDDRRQLQHLKSKTLRERWLLEGAPSSTAEEGDALKKQMQEDDLKAKELEESIQRLEKELEQLENGISASSTKENMAEETRAGGKEDKSRGPGSCGGAAGLHSPVCPPAMYSVEITVLSSTTSLPKDRSVQGVKVYEDEMKVVHAVRVEDGALENGLQQLSSSEVDELIHKADEVTLSEASEAAKGPRSNPPSQKATPRKEITGVQAKPVETPKLMPAGQGPEPSEEKPVTMIFMGYQNVEDEDETKKVLGLEGTIRAELVVIEDAENKAASATGKDHAPPNGSAVATSVPQKVENQAGEPPAANSTDPKDAEQDLDAKKQRCKCCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKZ1</accession>
    <name>A0A670KKZ1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein AEBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">AEBP2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the AEBP2/jing C2H2-type zinc-finger family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028601453.1">
        <property type="nucleotide sequence ID" value="XM_028745620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KKZ1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038728.1">
        <property type="protein sequence ID" value="ENSPMRP00000036559.1"/>
        <property type="gene ID" value="ENSPMRG00000023576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604966"/>
    <dbReference type="KEGG" id="pmua:114604966"/>
    <dbReference type="CTD" id="121536"/>
    <dbReference type="GeneTree" id="ENSGT00510000048519"/>
    <dbReference type="OMA" id="FAENICL"/>
    <dbReference type="OrthoDB" id="9984614at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000323">
        <property type="entry name" value="zinc finger protein AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000471">
        <property type="entry name" value="Zinc finger protein AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052130">
        <property type="entry name" value="AEBP2/jing_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059034">
        <property type="entry name" value="SH3_AEBP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26014">
        <property type="entry name" value="SH3_AEBP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="362"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="138"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="523" mass="53429" checksum="F7A49DBDE43C9505" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLS6</accession>
    <name>A0A670KLS6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 150C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMEM150C</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KLS6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037824.1">
        <property type="protein sequence ID" value="ENSPMRP00000035682.1"/>
        <property type="gene ID" value="ENSPMRG00000023061.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234578"/>
    <dbReference type="OMA" id="MRAQIWG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 150C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="8">
        <location>
            <begin position="147"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="387" mass="42184" checksum="FCB805570E19050C" modified="2020-06-17" version="1">MRAQIWGGAGLARGTQEGAAASEDGEDAARPPPPLLGVCLPPPLLISPLRERRRQPGAPSPFVSGAGEAPAAARGGRQPQTPPLPRGEALLPACPVLLPPPIALPPPASSRRCNSTRDPRARPTPRRLRAPLPSQLFGMDGKKCSVWMFLPLVLTLFTSAGLWIVYFIAVEDNNIIPLNVLDRKEGPQKPPYISIAGDAPPASCVFSQVMNMAAFLALVVAVLRFIQLKPKVLNPWLNVSGLVALCLASFGMTLLGNFQLSNDEEIHNVGTSLTFGFGTLACWIQSALTLKINLKNEGRKAGIPRVVLSAAITLCVVLYFILMSQKFHMHAARIQWGMVMCFLCYFGSFAVEFRHYRFEIICSEYQENFLSFSESLSEASEYQTDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLV5</accession>
    <name>A0A670KLV5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Iron-sulfur cluster co-chaperone protein HscB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HSCB</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Plays an essential role in hematopoiesis.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with ISCU (cytoplasmic form); this interaction stabilizes the (Fe-S) clusters on ISCU. Interacts with the CIA complex member CIAO1 (via LYR motif).</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with ISCU and HSPA9 to form an iron-sulfur transfer complex. Interacts with SDHAF1 (via the first LYR motif); the interaction recruits the iron-sulfur transfer complex composed of HSC20, HSPA9 and ISCU and mediates the incorporation of iron-sulfur clusters into SDHB which also interacts with HSC20. Interacts with the cytoplasmic form of ISCU and with CIA complex member CIAO1 (via LYR motif).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KLV5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037858.1">
        <property type="protein sequence ID" value="ENSPMRP00000035716.1"/>
        <property type="gene ID" value="ENSPMRG00000023079.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000037864.1">
        <property type="protein sequence ID" value="ENSPMRP00000035722.1"/>
        <property type="gene ID" value="ENSPMRG00000023079.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000037869.1">
        <property type="protein sequence ID" value="ENSPMRP00000035727.1"/>
        <property type="gene ID" value="ENSPMRG00000023079.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000037874.1">
        <property type="protein sequence ID" value="ENSPMRP00000035732.1"/>
        <property type="gene ID" value="ENSPMRG00000023079.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008206"/>
    <dbReference type="OMA" id="LMFIERF"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.20:FF:000002">
        <property type="entry name" value="HscB mitochondrial iron-sulfur cluster co-chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000042">
        <property type="entry name" value="Iron-sulfur cluster co-chaperone protein HscB, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040682">
        <property type="entry name" value="HscB_4_cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18256">
        <property type="entry name" value="HscB_4_cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="14">
        <location>
            <begin position="82"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="245" mass="27592" checksum="13751A5125FD3FAC" modified="2020-06-17" version="1">MRWDALSRRLRWAAAAGPRRLLGPRAPPWAAAAAAWPSPSSSSPPSPASCWSCGLALPPASPPPRFFCPSCRALQPPEPRADLFRLLGCERSFQVDVGLVQQRFRSLQRALHPDFFSRRPQAEQNFSKQHSSLANKAYRTLLSPLSRGLYLLELNGVELEKGTDAEADPEFLSEIMEINEKLSDANNDAKIEEMENFIAAKQEELIKDVSRAFEHDDLQEAKKYLAKMKYFANLEEKLKKKKIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HK57</accession>
    <name>A0A670HK57_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BARX homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BARX1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BAR homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HK57"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000213.1">
        <property type="protein sequence ID" value="ENSPMRP00000000204.1"/>
        <property type="gene ID" value="ENSPMRG00000000139.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160218"/>
    <dbReference type="OMA" id="EFHTSHY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055123">
        <property type="term" value="P:digestive system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045446">
        <property type="term" value="P:endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF12">
        <property type="entry name" value="BARX HOMEOBOX 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="100" mass="11446" checksum="8D28C1B75D8BACD9" modified="2020-06-17" version="1">MGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKEAEKQAESLGSPCQVSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HL23</accession>
    <name>A0A670HL23_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras association domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RASSF7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAP2K7 and GTP-bound NRAS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028591298.1">
        <property type="nucleotide sequence ID" value="XM_028735465.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591306.1">
        <property type="nucleotide sequence ID" value="XM_028735473.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591315.1">
        <property type="nucleotide sequence ID" value="XM_028735482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HL23"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000341.1">
        <property type="protein sequence ID" value="ENSPMRP00000000323.1"/>
        <property type="gene ID" value="ENSPMRG00000000246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599765"/>
    <dbReference type="KEGG" id="pmua:114599765"/>
    <dbReference type="CTD" id="8045"/>
    <dbReference type="GeneTree" id="ENSGT00950000182839"/>
    <dbReference type="OMA" id="MSRWRHQ"/>
    <dbReference type="OrthoDB" id="10051571at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16135">
        <property type="entry name" value="RA_RASSF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000132">
        <property type="entry name" value="Ras association domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033631">
        <property type="entry name" value="RASSF7_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF11">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ras-associating" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="439" mass="50058" checksum="8F65568704C6CE42" modified="2020-06-17" version="1">MELKVWVDGVQRVVCGVSEQTTCQEVVIALARAIGQTGRYVLIQRLREKERQLLPHECPVESMAKCGQYANDVQFILQRTGPSLTERPSSDSAPQVPERTFVRASLPIKPRPVGTEVPRPRQPKKSLTFNLGPMASSDLHAKNKLKQHKKDSVGWREGASGGLLSKEELFKTILHQQEHLYSLEMQGDALEMDLRHWELNRGCCQEDEILHLEQLIRQNESELGEEGFWQSELRSEKECERERQEKVHTLRATMEEYTQKIHELMVKTEALEREIQWEISERAKRAKEAPRQSPTELEEMAAKMKRDLEAKAKQSAHLESSLETVGKALEEAEQSLQAQNQELEELNKELRQCNLQQFIQQTGAMVTSPQPRSEAEPQLDETSSELLAHQRTGDLLEPSADSPPRATAKQFLGNPRNLQNPLVSSLNPEVMSAKQSIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNC2</accession>
    <name>A0A670HNC2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein 1</fullName>
            <ecNumber evidence="6">4.1.99.22</ecNumber>
            <ecNumber evidence="7">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MOCS1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Isoform MOCS1A and isoform MOCS1B probably form a heterooligomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="6"/>
    <dbReference type="EC" id="4.6.1.17" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A670HNC2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001078.1">
        <property type="protein sequence ID" value="ENSPMRP00000001016.1"/>
        <property type="gene ID" value="ENSPMRG00000000749.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016567"/>
    <dbReference type="OMA" id="QMSECFC"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000117">
        <property type="entry name" value="molybdenum cofactor biosynthesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001199">
        <property type="entry name" value="PRK00164.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="21">
        <location>
            <begin position="153"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="475" mass="52139" checksum="DD8D7C1502BC2CBC" modified="2020-06-17" version="1">MRQHASNLLQIPACLSKRPGSLLAAGSDLPFLSVPGPAGRSAQLCVCIYLSEFGAGASGGNSGCCCEFALAGAMAAALGVARAQRARRCLLLQLPGAFRAPLGRGCRSGVPARQQQQQALAVPSASAEEITSARRKGFLAEHAAPFSAFLTDGFGRQHNYLRISLTEKCNLRCQYCMPEEGVQLTPKSELLSTQEIITLARLFVKEGVDKIRLTGGEPLIRPDVIDIIAQMRKLEGLQTIAVTTNGINLARLLPRLKEAGLNAINISLDTLVPAKFEFIVRRKGFHKVMEGIQKALELGYDPVKVNCVVMRGLNEDELVDFVALTEKQPLDVRFIEYMPFDGNKWNFRKMVSYKEMLDTIKQRWPELEKVPCEEASSTAKAYKVPRFQGQVSFITSMSEHFCGSCNRLRITADGNLKVCLFGNAEVSLRDHLRSNASEEELVQIIGAAVGRKKKQHAGMFNISQMKNRPMILIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNZ0</accession>
    <name>A0A670HNZ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">BRISC and BRCA1-A complex member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BABAM2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
        <text evidence="15">Localizes at sites of DNA damage at double-strand breaks (DSBs).</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the BABAM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028580275.1">
        <property type="nucleotide sequence ID" value="XM_028724442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HNZ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001465.1">
        <property type="protein sequence ID" value="ENSPMRP00000001378.1"/>
        <property type="gene ID" value="ENSPMRG00000001027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594574"/>
    <dbReference type="KEGG" id="pmua:114594574"/>
    <dbReference type="CTD" id="9577"/>
    <dbReference type="GeneTree" id="ENSGT00390000004208"/>
    <dbReference type="OMA" id="AGSTWRH"/>
    <dbReference type="OrthoDB" id="538811at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000152">
        <property type="term" value="C:nuclear ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23664">
        <property type="entry name" value="BRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010358">
        <property type="entry name" value="BRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15189">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15189:SF7">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06113">
        <property type="entry name" value="BRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="13 15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 15" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="383" mass="43495" checksum="2D47417070616AC9" modified="2020-06-17" version="1">MSPEVALHRISPALSPFVSNVVRNGKVGLDATNCLRITDLKSGCMSLTLGPSCDRFKLHIPYAGETLKWDIIFNAYYPELPPDFIFGEDAEFLPDPSALHNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGELSARFLLKLPVDFSNIPTYLLKDANEDPGEDVALLSVSFEDTEATQVFPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCQLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLYFPRDQPTLTFQSVYHFTNSGELYSQAQKNYPYSPRWDGNEMAKRAKAHFKTFVPQFQEAAFANGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HR63</accession>
    <name>A0A670HR63_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc transporter SLC39A7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 39 member 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Zrt-, Irt-like protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SLC39A7</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HR63"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001810.1">
        <property type="protein sequence ID" value="ENSPMRP00000001705.1"/>
        <property type="gene ID" value="ENSPMRG00000001206.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160076"/>
    <dbReference type="OMA" id="DFHHHGH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110075">
        <property type="term" value="P:regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098773">
        <property type="term" value="P:skin epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF25">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0864">Zinc transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025561172" description="Zinc transporter SLC39A7" evidence="14">
        <location>
            <begin position="24"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="266"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="491" mass="52104" checksum="2E37EFC6D4F36347" modified="2020-06-17" version="1">MCLAPDVATAVVLCLVLLWGASAQHEGFHGHAHEDFHHGHSHAHGHGHTHEDIWHGHAHDDGHTHEGIWHGHDDGHSHGGHSHEGLHHGHSHEDFHHRHSHGHEGHHHGHGHVHDGPHHHSNSHESPAGGPSRAQSFPGNEKALPRREKLEPLQLWTYAIGATLLISAAPYFILFLIPVESNTSQHQALLKLLLSFASGGLLGDAFLHLIPHALGELKGSPLVLSLHPASCLGWVALPSPPLIPVSCDSGGLDYMALRGPFQPCDSVPRSFSPPEPHSHHGEGAGHSHVKPESHGHSHQVPKAKSSDDEAEKEPLRGKTSEKTTAPSQGKQKPPDSGEVVHLAMRVSGYLNLAADFAHNFTDGLALGASFLAGGTVGAVTTLTVLLHEVPHEVGDFAILVQSGCSKKKAMKLQLVTALGALAGTVCSLLAEGVGEAATAWILPFTAGGFIYVATVSVIPELLQDSGPVQSLLEVLGLVAGVAMMVFIAQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRJ6</accession>
    <name>A0A670HRJ6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Flap endonuclease 1</fullName>
            <shortName evidence="17">FEN-1</shortName>
            <ecNumber evidence="17">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FEN1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14 17">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300; can bind simultaneously to both PCNA and EP300. Interacts with DDX11; this interaction is direct and increases flap endonuclease activity of FEN1. Interacts with WDR4; regulating its endonuclease activity. Interacts with POLB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Nucleus</location>
            <location evidence="17">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Nucleus</location>
            <location evidence="17">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="17">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="17"/>
    <dbReference type="RefSeq" id="XP_028592709.1">
        <property type="nucleotide sequence ID" value="XM_028736876.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592718.1">
        <property type="nucleotide sequence ID" value="XM_028736885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HRJ6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002472.1">
        <property type="protein sequence ID" value="ENSPMRP00000002323.1"/>
        <property type="gene ID" value="ENSPMRG00000001679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600577"/>
    <dbReference type="KEGG" id="pmua:114600577"/>
    <dbReference type="CTD" id="2237"/>
    <dbReference type="GeneTree" id="ENSGT00940000155807"/>
    <dbReference type="OMA" id="MGIPWVQ"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045876">
        <property type="term" value="P:positive regulation of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 17" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 17" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="21">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="20">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="382" mass="42883" checksum="8E5F0DE6BD3CB472" modified="2020-06-17" version="1">MGIHGLAKLIADIAPGAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGADMLQNEEGETTSHLMGMFYRTIRMVENGIKPVYVFDGKPPQLKSGELAKRTERRAEAEKQLQEAKEAGEEENVEKFSKRLVKVTKQHNDECKKLLTLMGIPYVDAPGEAEASCAALVKASKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRLLQDLSLTQKEFVDLCILLGCDYCESIRGIGPKRAVELIKQHKSIEKILQQIDAKKYSVPENWLHKEAQLLFLEPEVVDPEAVDLKWNEPDEEELVNFLCGEKQFNEERIRNGVKRLNKSRQGSTQGRLDDFFKVTGSITSAKRKEPEPKGSARKKARGGGALTSKFKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HS79</accession>
    <name>A0A670HS79_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gap junction protein epsilon 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GJE1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HS79"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002215.1">
        <property type="protein sequence ID" value="ENSPMRP00000002080.1"/>
        <property type="gene ID" value="ENSPMRG00000001528.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286949"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF1">
        <property type="entry name" value="GAP JUNCTION EPSILON-1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="8">
        <location>
            <begin position="270"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="350" mass="38295" checksum="F91EA4CB4A078F2C" modified="2020-06-17" version="1">MAHRLAGISSSSISGGSPAGEGCPNRSLWDLFRGHERSLSCPSGIGELAVDESVLRDARFLIDSSGSPGRAEATRWAAGSSGLDGCQAGSPFSCLPLSLPLRLAPSGRGIAAPGALRSGRSAFPLQDDRDAPPRTVAAEQQAGAWMGPPNNATPGLRLLRPPTVVGQFHTLFFGSVRMFFLGVLGFAVYGNEALHFSCEPDKRDINLFCYNQFRPITPPVFWALQLVTVLVPGAIFHLYAACKSITQEDILQRPAYTVFYILSVLLRIILEVVAFWLQSQLFGFQVNPLYRCDAGALDKKFNITRCMVPEHFEKTIFLIAMYTFTVITIMLCIAEIFEILCRRLGFLNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTS5</accession>
    <name>A0A670HTS5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Astrotactin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ASTN1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028588176.1">
        <property type="nucleotide sequence ID" value="XM_028732343.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000003372.1">
        <property type="protein sequence ID" value="ENSPMRP00000003144.1"/>
        <property type="gene ID" value="ENSPMRG00000002234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598555"/>
    <dbReference type="KEGG" id="pmua:114598555"/>
    <dbReference type="CTD" id="460"/>
    <dbReference type="GeneTree" id="ENSGT00390000003140"/>
    <dbReference type="OMA" id="XSRFILL"/>
    <dbReference type="OrthoDB" id="9934301at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007158">
        <property type="term" value="P:neuron cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <source>
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    <sequence length="1380" mass="153128" checksum="FE4C6A4C8BA501AC" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Bellati A."/>
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>IDENTIFICATION</scope>
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        </reaction>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="271" mass="30041" checksum="901D489655333E3E" modified="2020-06-17" version="1">MPGTGRGPVLTHRRRRRPSSPPPRRASPRAALTGKLERLPRRKYRPPSPRQPPRSKTPRDAQRRKCVTRSPAWGVLDAVPLSNDNPQEGPPSVRTGLSVQQDGRPLVEIHPPHRFLASFSHFPSQNSVLRCPIGGARTSGSRAPRPSRGKMAARALVQYVVLRGDLRREPLSWPLGASVAQACHAALAVVHAHYQHPDTAAYLAQGGSMRTVVLEAPDECALTALAEALQQNNIDHKVWVEQPENIATCIALRPYPKEHVHQYLKKFKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HY26</accession>
    <name>A0A670HY26_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Rac GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Male germ cell RacGap</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">RACGAP1</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
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                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="4">Secretory vesicle</location>
            <location evidence="4">Acrosome</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HY26"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007405">
        <property type="term" value="P:neuroblast proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rac GTPase-activating protein 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C1-like_sf"/>
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    </dbReference>
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        <property type="entry name" value="RAC GTPASE ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="22 32" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="421"/>
            <end position="470"/>
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        <location>
            <begin position="35"/>
            <end position="57"/>
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        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
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            <begin position="715"/>
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        <location>
            <begin position="197"/>
            <end position="245"/>
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        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
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        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="33">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
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        <location>
            <begin position="739"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="767" mass="85673" checksum="8B2FB671BF45C26E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ03</accession>
    <name>A0A670HZ03_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
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    </dbReference>
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        <property type="entry name" value="RIBONUCLEASE H"/>
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    </dbReference>
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    </dbReference>
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            <end position="415"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="483" mass="55511" checksum="263EC41F9A0B520B" modified="2020-06-17" version="1">MLNADFQRIARRDKKAFLNEQCKQIEENNRMGRTRDLFKKIGDMKGTFRTKITIIKDKSGKDLTEAEEIKKRWQEYTEELYQKDMDVSYTPGSVVADLEPDILESEVKWALESTANNKASGSDGIPAELFKILKDDAVKVLHSICQQIWKTQQWPEDWRRSVYIPVPKKGSAKECSNYRTIALISHASKVMLKILQGRLKQYVDRELPEVQAGFRRGRGTRDQIANMRWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTTDWFKIGKGVRQGCILSPCLFNLYAEFIMRKAGLDESQAGIKIAGRNINNLRYADDTTLMAESEEELKNLLMRVKEESAKYGLKLNIKKTKIMATGPITSWQIEGEEMEAVRDFTFLGSMITADGDSSHEIKRRLLLGRRAMTGLDSILRSRDVTLPTKVRIVKAMVFPVVMYGSESWTIKKADFLKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I420</accession>
    <name>A0A670I420_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear receptor subfamily 0 group B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NR0B1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family. NR0 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583284.1">
        <property type="nucleotide sequence ID" value="XM_028727451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I420"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006576.1">
        <property type="protein sequence ID" value="ENSPMRP00000006182.1"/>
        <property type="gene ID" value="ENSPMRG00000004180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596198"/>
    <dbReference type="KEGG" id="pmua:114596198"/>
    <dbReference type="CTD" id="190"/>
    <dbReference type="GeneTree" id="ENSGT00390000015719"/>
    <dbReference type="OMA" id="RCRCCTD"/>
    <dbReference type="OrthoDB" id="9926883at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032448">
        <property type="term" value="F:DNA hairpin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030325">
        <property type="term" value="P:adrenal gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035987">
        <property type="term" value="P:endodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033327">
        <property type="term" value="P:Leydig cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030238">
        <property type="term" value="P:male sex determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033144">
        <property type="term" value="P:negative regulation of intracellular steroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010894">
        <property type="term" value="P:negative regulation of steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035902">
        <property type="term" value="P:response to immobilization stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060008">
        <property type="term" value="P:Sertoli cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07350">
        <property type="entry name" value="NR_LBD_Dax1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033544">
        <property type="entry name" value="NR0B1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24081">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24081:SF1">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="15"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="322" mass="35839" checksum="CF9BEB4742E2E795" modified="2020-06-17" version="1">MACVERCRCCTGSRRQSSILYNILKSEEQRQQQRRQAGSEQPPPPPPPPPPPPLSPGGHAACPGCSCGSQKRVALQSPQVACKAASAVLVKTLRFVKNVPSFQELPLDEQLVLVRSSWAPLLVLGLAQDRVHFETVETTEPSMLQRILTEKRAEEQRQQQQQQLQHRQRRQPQHHFLLLHKTQEKLAAATCGGSSSSSSSSPKLLSAEEIEAIQSFLGKCWSLDITTKEYAYLKGTVLFNPDLPGLQCVQYIQGLQQEAQQALNEHVRMIHRGDQTRFAKLNAALSMLGSINANVISELFFRPIIGTVNMDDMLLEMLCAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4C2</accession>
    <name>A0A670I4C2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LNPK</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Endoplasmic reticulum membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
            <orientation evidence="1 5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I4C2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006713.1">
        <property type="protein sequence ID" value="ENSPMRP00000006307.1"/>
        <property type="gene ID" value="ENSPMRG00000004264.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001859"/>
    <dbReference type="OMA" id="CGYFNPS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032330">
        <property type="term" value="P:regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="7">
        <location>
            <begin position="346"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="506" mass="55930" checksum="4E1F0EFF4A279695" modified="2020-06-17" version="1">MAALRPFPPLHPRRTVSLLHTALPQDGRAACVASARTSFLDLRDGEEAEGGEGGRRGGDEPRPPPPPPPPPPPRGSAASSGAGKVRVQNRGAEKETKSSTIEVLEKIDKDIQALEEFREKNQRQQKLWVGRFILYSSVLYLISCLIIYLWYLPDEWTARFVMTLPLFAFPLIIWSIRTLLIFFFSKRTERNNEALEVLKAEKKKILEEVMEKETYKAAKLILERFDPEAKKAKDVEPPSAGASAVPRPGQELRHRTPVRGNVSPPTPASPKQGSPKGPNPAPPTPGLQREISAPGGPPERSVTSPLQPNVLPRHPGSRATSVPGMGLHPPGPPLARPILPRERGALDRIVEYLVGDGPQNRYALICQQCSSHNGMALKEEFEYIAFRCAYCFFLNPARKTRPQAPRLPDFSAEKKQPTEVQSTTEPLQSEEEKLEENEMAEDPLEEATQLTETNQEDDQALTVEDQSRDVVGVAAEEQPGSEAKTATTDSEFAVPASQRQEPLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I7A3</accession>
    <name>A0A670I7A3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Low-density lipoprotein receptor-related protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Apolipoprotein E receptor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Very low-density lipoprotein receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">LRP8</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="23">Homooligomer. Binds to the extracellular matrix protein Reelin/RELN. Interacts with LRP8. Interacts with LDLRAP1. Interacts with SNX17. Interacts with DAB1. Interacts with PCSK9. Interacts with PAFAH1B3 and PAFAH1B2, the catalytic complex of (PAF-AH (I)) heterotetrameric enzyme; these interactions may modulate the Reelin pathway. Interacts with STX5; this interaction mediates VLDLR translocation from the endoplasmic reticulum to the plasma membrane. Interacts with CLU.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Homooligomer. Interacts with VLDLR. Reelin associates with two or more receptor molecules. Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17. Interacts with PCSK9. Interacts with MDK; this interaction is calcium dependent. Interacts with CLU.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Clathrin-coated pit</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I7A3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008074.1">
        <property type="protein sequence ID" value="ENSPMRP00000007544.1"/>
        <property type="gene ID" value="ENSPMRG00000004977.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154819"/>
    <dbReference type="OMA" id="CESPTKF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034361">
        <property type="term" value="C:very-low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034185">
        <property type="term" value="F:apolipoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038025">
        <property type="term" value="F:reelin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030229">
        <property type="term" value="F:very-low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021819">
        <property type="term" value="P:layer formation in cerebral cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900006">
        <property type="term" value="P:positive regulation of dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061003">
        <property type="term" value="P:positive regulation of dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045088">
        <property type="term" value="P:regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021517">
        <property type="term" value="P:ventral spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000052">
        <property type="entry name" value="low-density lipoprotein receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000002">
        <property type="entry name" value="low-density lipoprotein receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000136">
        <property type="entry name" value="low-density lipoprotein receptor isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000113">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000038">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000046">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000053">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000057">
        <property type="entry name" value="Very low density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF15">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 26" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="13 30" id="KW-0732">Signal</keyword>
    <keyword evidence="11 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="21" id="KW-0850">VLDL</keyword>
    <feature type="signal peptide" evidence="30">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025360016" description="Low-density lipoprotein receptor-related protein 8" evidence="30">
        <location>
            <begin position="28"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="863"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="31">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="31">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="28">
        <location>
            <begin position="483"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="28">
        <location>
            <begin position="530"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="28">
        <location>
            <begin position="573"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="28">
        <location>
            <begin position="617"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="27">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="27">
        <location>
            <begin position="40"/>
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        <source>
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    </evidence>
    <sequence length="124" mass="13298" checksum="63D71F47F36ED104" modified="2020-06-17" version="1">MKALLIFVVAGSFFMQPTGSLKCYTCNTQVNNNNCKGQQNCDGIGQVCKTDVIGVVGLFNVISKECTASCDPYFSDFKVGRRNVSCCATDLCNVNGASDFKMGYVQVALALSASLACILLRSRL</sequence>
</entry>
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    <accession>A0A670IBA9</accession>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Sabatino S.J."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
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                <person name="While G.M."/>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <name>Zn(2+)</name>
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        </cofactor>
    </comment>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="974" mass="109054" checksum="80ABB320F7CC0127" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IE96</accession>
    <name>A0A670IE96_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 23">7-dehydrocholesterol reductase</fullName>
            <shortName evidence="23">7-DHC</shortName>
            <ecNumber evidence="18 23">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20 23">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC114596913</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17737"/>
            <dbReference type="ChEBI" id="CHEBI:27910"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:46741"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:23986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 23">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 23">Endoplasmic reticulum membrane</location>
            <topology evidence="1 23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="18 23"/>
    <dbReference type="RefSeq" id="XP_028584623.1">
        <property type="nucleotide sequence ID" value="XM_028728790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IE96"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010467.1">
        <property type="protein sequence ID" value="ENSPMRP00000009822.1"/>
        <property type="gene ID" value="ENSPMRG00000006570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596913"/>
    <dbReference type="GeneTree" id="ENSGT00390000000417"/>
    <dbReference type="OMA" id="VKHPVNL"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="UniPathway" id="UPA00063"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000004">
        <property type="entry name" value="7-dehydrocholesterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 23" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="5 23" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8 23" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 23" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16 23" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="416" mass="48560" checksum="8F25EA0305CB9955" modified="2020-06-17" version="1">MSCDQYSCSLTKPAIDLVTGKASLLDIWHKTPPLTWKAATLYASWVIFQVFLYMLPDFCHKFIPYFRGGVQEGAVTPAGAVLKYEVNGLQAWLITHILWFANAYHFHWFSPTIIFDNWIPLLWCANILGYAVSIFVMIKAYYFPTNAEDRKFTGNFFYDFMMGIEFNPRLGKWFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGQVTNSMILVNVLQGIYVLDFFWNEAWYLKTMDICHDHFGWYLGWGDTVWLPYLYTLQGLYLVYHPVHLATSSAVGILLFGLVGYYIFRMTNHQKDLFRRTDGNCKIWGRKPKYIECSYTSTDGIKHHSKLLTSGFWGVARHFNYTGDLMGSLAYCLCCGFEHILPYFYIIHMTILLVHRCIRDEHRCSSKYGNNWKKYTDAVPYRLIPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGV9</accession>
    <name>A0A670IGV9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="8">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">POLR3F</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Directly interacts with POLR3C. Interacts with TBP and TFIIIB90 and GTF3C4. Interacts with MAF1. As part of the RNA polymerase III complex, interacts with PKP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IGV9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011608.1">
        <property type="protein sequence ID" value="ENSPMRP00000010874.1"/>
        <property type="gene ID" value="ENSPMRG00000007233.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009679"/>
    <dbReference type="OMA" id="VGTTKKC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032728">
        <property type="term" value="P:positive regulation of interferon-beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000237">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="258" mass="28933" checksum="7C8A0F42EF73AFF6" modified="2020-06-17" version="1">MPHMEAQQRAVAINRLLSMGQLDLLRSSTGLLYRIKESQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQTKAEAARESKQNPMIQRNSSFASSHEVWKYISELGVSKVELSMEDIETILNTLIYDGKVEMTIVAAKEAAAGSVDGHMKLYRAINPIIQPTGLVRTPCGLCPVSYFSGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJY5</accession>
    <name>A0A670IJY5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-synuclein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SNCB</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the synuclein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028574277.1">
        <property type="nucleotide sequence ID" value="XM_028718444.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574278.1">
        <property type="nucleotide sequence ID" value="XM_028718445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IJY5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012741.1">
        <property type="protein sequence ID" value="ENSPMRP00000011931.1"/>
        <property type="gene ID" value="ENSPMRG00000007969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591429"/>
    <dbReference type="CTD" id="6620"/>
    <dbReference type="GeneTree" id="ENSGT00950000183175"/>
    <dbReference type="OMA" id="GWRERWM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016234">
        <property type="term" value="C:inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903136">
        <property type="term" value="F:cuprous ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.700:FF:000001">
        <property type="entry name" value="Alpha-synuclein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001058">
        <property type="entry name" value="Synuclein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002461">
        <property type="entry name" value="Synuclein_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13820:SF4">
        <property type="entry name" value="BETA-SYNUCLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13820">
        <property type="entry name" value="SYNUCLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01387">
        <property type="entry name" value="Synuclein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01213">
        <property type="entry name" value="BSYNUCLEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01211">
        <property type="entry name" value="SYNUCLEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118375">
        <property type="entry name" value="Synuclein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="133" mass="14028" checksum="CC6415DCB88FA4F2" modified="2020-06-17" version="1">MDAFMKGLSKAKEGVVAAAEKTKEGVAVAAEKTKEGVLYVGSKTREGVAGVASVAEKTKEQASQLGGAVFSGAGNIAAATGLVKKEDFPTDLKPEEVGQEAVEEPLIEPLLEPEGENYEEPPQEEYQEYEPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IK74</accession>
    <name>A0A670IK74_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IK74"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012871.1">
        <property type="protein sequence ID" value="ENSPMRP00000012056.1"/>
        <property type="gene ID" value="ENSPMRG00000008041.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159725"/>
    <dbReference type="OMA" id="IHITLMD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
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        <property type="entry name" value="Cadherin_N"/>
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        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
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        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24028:SF234">
        <property type="entry name" value="PROTOCADHERIN GAMMA-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025500187" description="Cadherin domain-containing protein" evidence="14">
        <location>
            <begin position="32"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="690"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="136"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="245"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="350"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="455"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="581"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="837" mass="91862" checksum="A1E13B03AB025278" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKB4</accession>
    <name>A0A670IKB4_PODMU</name>
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        <recommendedName>
            <fullName evidence="8">Gypsy retrotransposon integrase-like protein 1</fullName>
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        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A670IKB4"/>
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        <property type="protein sequence ID" value="ENSPMRP00000012076.1"/>
        <property type="gene ID" value="ENSPMRG00000008068.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240511"/>
    <dbReference type="OMA" id="WAFREAP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="182"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="766" mass="87869" checksum="0E3D3B0CD811D847" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKM8</accession>
    <name>A0A670IKM8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A670IKM8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012959.1">
        <property type="protein sequence ID" value="ENSPMRP00000012139.1"/>
        <property type="gene ID" value="ENSPMRG00000008114.1"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008367">
        <property type="entry name" value="Regucalcin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF64">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01791">
        <property type="entry name" value="REGUCALCIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="18"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="295" mass="33188" checksum="35AFC9CDCF9A11C3" modified="2020-06-17" version="1">VIMSSIKIETVVKQKNRMGECPTWEERENSLVYVDINSQKVCRWNSVTNEVQCVSVDARVGSVALRKCGGYVIALGRKFAFLNWEDQVVTDIYEVEQDKPNNRFNDGKVDPRGSFYAGTMAEETAPGVRARQQGALYTLFPDCGVVKQLEKVDISNGLDWSLDHRTFFYIDSLAYAVQAFDYDMRTGMIDCCSCRPVYKLEKEEAMPDGMCIDREGKLWVACIDGGRVIRIDPEAGKRIQTVKMPASRITSCCFGGKDYSEMYVTSAYDGLDSDALAKEHQAGEIFKVNNLSFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IL02</accession>
    <name>A0A670IL02_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RT_POL"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="342"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="796" mass="90905" checksum="086B4AB83BFA0988" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IL71</accession>
    <name>A0A670IL71_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short chain dehydrogenase/reductase family 16C member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SDR16C5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028592731.1">
        <property type="nucleotide sequence ID" value="XM_028736898.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028736899.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028736900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IL71"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013285.1">
        <property type="protein sequence ID" value="ENSPMRP00000012441.1"/>
        <property type="gene ID" value="ENSPMRG00000008314.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600589"/>
    <dbReference type="KEGG" id="pmua:114600589"/>
    <dbReference type="CTD" id="195814"/>
    <dbReference type="GeneTree" id="ENSGT00940000156731"/>
    <dbReference type="OMA" id="RTPMIKM"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043616">
        <property type="term" value="P:keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="311" mass="34186" checksum="C8601431789FFDBC" modified="2020-06-17" version="1">MNFFLETLRVIGLAIYFTLENFFLLFIPVRKKNVTGEIVLITGAGSGIGRLMALKFARLGATLVLWDISVEGNKETARLARKNGAARVHNYTCDCSKRQEVYQVADQVKKEVGDVSILINNAGIVTGKRFLDSPDAMIQKSMEVNTMAHFWTVKAFVPAMVASNHGHVVTISSAAGLVGVTGLADYCASKFAVVGFAESLAIEMLALGKTGVKSTIVCPFFINTGMFDGCKTKWPRFLPVMEPDYAAERIISGILRNQVYVYIPRSITLLVALKGLIPTKLGMLLGDYMGYFHFMETFTGRANKIEDNKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILK8</accession>
    <name>A0A670ILK8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase regulatory subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">p55PIK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PIK3R3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3K p85 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ILK8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013842.1">
        <property type="protein sequence ID" value="ENSPMRP00000012963.1"/>
        <property type="gene ID" value="ENSPMRG00000008673.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cell migration involved in sprouting angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="iSH2_PIK3R3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2_cSH2_p85_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2_nSH2_p85_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase regulatory subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase regulatory subunit gamma b"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative phosphatidylinositol 3-kinase regulatory subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035020">
        <property type="entry name" value="PI3kinase_P85_cSH2"/>
    </dbReference>
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        <property type="entry name" value="PI3kinase_P85_nSH2"/>
    </dbReference>
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        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00678">
        <property type="entry name" value="PI3KINASEP85"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="276"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="568"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057933"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="671" mass="77737" checksum="5BB601E98EB90B29" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILS9</accession>
    <name>A0A670ILS9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MARVEL domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MARVELD3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ILS9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013508.1">
        <property type="protein sequence ID" value="ENSPMRP00000012646.1"/>
        <property type="gene ID" value="ENSPMRG00000008464.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183102"/>
    <dbReference type="OMA" id="YTHNRDY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031435">
        <property type="term" value="F:mitogen-activated protein kinase kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010633">
        <property type="term" value="P:negative regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050680">
        <property type="term" value="P:negative regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902414">
        <property type="term" value="P:protein localization to cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053077">
        <property type="entry name" value="MARVEL_domain_protein_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34609">
        <property type="entry name" value="GEO08273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34609:SF17">
        <property type="entry name" value="GEO08273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="8">
        <location>
            <begin position="74"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="283" mass="30718" checksum="76D3FBED04F551C3" modified="2020-06-17" version="1">MADAGRRPGKPRDWRHDRPAVVAVGEQPWPWRQQQQHQQQHRPPPSRGTTLASLDAPAEARGGGGLLDKALCRALCTARACCQQLQLLLCMLIVICSSVSYNSTGGYTGLFSLGSIYYYQYGGAYSGLSGADGEKAQQLDAQFHQLKVPPAQVAMAVGGALMAFACFQIVASLFRVPWHCPAWLIAEAILDVAIAIGLVPALYFYYHRLHEIYASSLCKERENLYQSKGYRGFGCSLHGAEIAVGFFAGAAIVAFAVAVVLAVRGFKIVRTLQAKPSSHSYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILX9</accession>
    <name>A0A670ILX9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670ILX9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013079.1">
        <property type="protein sequence ID" value="ENSPMRP00000012252.1"/>
        <property type="gene ID" value="ENSPMRG00000008199.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000248530"/>
    <dbReference type="OMA" id="RWTEDEN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF30">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="481"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="829" mass="94295" checksum="4357B307BA160B38" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INI4</accession>
    <name>A0A670INI4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related protein Rab-39B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114601472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028594465.1">
        <property type="nucleotide sequence ID" value="XM_028738632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670INI4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014087.1">
        <property type="protein sequence ID" value="ENSPMRP00000013196.1"/>
        <property type="gene ID" value="ENSPMRG00000008838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601472"/>
    <dbReference type="KEGG" id="pmua:114601472"/>
    <dbReference type="GeneTree" id="ENSGT00940000164873"/>
    <dbReference type="OMA" id="AFYRNCQ"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="214" mass="24402" checksum="B094B29C5C916FD9" modified="2020-06-17" version="1">MAVDSLWHYQFRIIMLGDSTVGKSCLLKRYAEGVFLESMNQTVGVDFYVHFLEIEPDLRIKLQFWDTAGQERFRSVTRSYYRNSAGGVLVFDLANRASFESIRKWHQEVMDTVKPHHIVFVLVGHKSDLEAERKVGQKEAEKLATLLEAKYIETSAKSNRNVGEAFQILTLGIYEALKSGKMRPSEQWDGVKSKLPPLAQPEAQAQERGKKCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IPE5</accession>
    <name>A0A670IPE5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Muskelin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer; may form higher oligomers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8. Interacts with GABRA1. Interacts with the C-terminal tail of PTGER3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IPE5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014818.1">
        <property type="protein sequence ID" value="ENSPMRP00000013865.1"/>
        <property type="gene ID" value="ENSPMRG00000009304.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001702"/>
    <dbReference type="OMA" id="MGHCMEY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000018">
        <property type="entry name" value="Muskelin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000035">
        <property type="entry name" value="Muskelin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000066">
        <property type="entry name" value="Muskelin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Muskelin N-terminal" evidence="13">
        <location>
            <begin position="14"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="725" mass="83700" checksum="D086F58AB061FC51" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITK7</accession>
    <name>A0A670ITK7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 221 member B</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ITK7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016554.1">
        <property type="protein sequence ID" value="ENSPMRP00000015498.1"/>
        <property type="gene ID" value="ENSPMRG00000010332.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00770000120611"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214">
        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214:SF3">
        <property type="entry name" value="PROTEIN FAM221B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14753">
        <property type="entry name" value="FAM221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="260" mass="28695" checksum="2490F5F4FE355007" modified="2020-06-17" version="1">MEEEPIEDVPMGPLEEEQEQGGQRTSSTALEVEEEIILPASTSLDDEDEETILPVSTSLEGEDGGKETSLPPSEWETSESLVPQEQSPSNEGSSSQPLESSEPSSSLASSPSSSAVSWRRQKDNQLQPLEEVEDTEETTAELSSILPQRSLEKKAKKKGAMVKKGALNYTVRPVVPAEKAELISVAKAMHRENFGKNVKELFHLEKEAALKSIETGLYIGWRCPEYLWDCFRVGDESKCFCGHLLKQHQVYVGKSWGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITY0</accession>
    <name>A0A670ITY0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">CTU2</name>
        <name evidence="3" type="synonym">NCS2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ITY0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015960.1">
        <property type="protein sequence ID" value="ENSPMRP00000014944.1"/>
        <property type="gene ID" value="ENSPMRG00000009965.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008797"/>
    <dbReference type="OMA" id="KQRKQMM"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="392" mass="43372" checksum="3BD6B80CAF1334E7" modified="2020-06-17" version="1">MHLLLFRRSCFKDYFVHKFRAMLGKNRCIYPGEKVLLAFSGGPASSSMVRQVQEGLSREAAKKLRFKPGIIYVDEGAVCGQSPGRREEIRSEVEMILQATGFPYHLVCLEEVFDLPGSVLHSIPHSATDHGGSYKEAVDGFIRWQQHEKTAGDSASSLEDQLARLNVQGSLQQEGPPVPGTRPPPVPHTEELTKLFGAVKTLTAKEELLQTLRNHLILHVARTSGYSKVMMGDSGTRVAVKLLTNLCLGRGPFCRHGDVLFLRPMREYTAKEIAFYNCFFGVPTVFMPALDTKTPDRASIHRLIESFLYKLQCDFPSTTSTVCRLNKLGSFCVLLKPAGVASSLPGPIQVLTLVFKALNYSGPTYLKDLLLPYRPSQVLRLADGALVVVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUG7</accession>
    <name>A0A670IUG7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IUG7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016923.1">
        <property type="protein sequence ID" value="ENSPMRP00000015848.1"/>
        <property type="gene ID" value="ENSPMRG00000010578.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000209945"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF73">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP FC1 ENV POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="373" mass="41227" checksum="4284F8ECAB4CC5AA" modified="2020-06-17" version="1">MYLEGWHYSVPPTAEWDTTGPQRCGGLATNLTYLLRQDPLHPAGTAPRQRGELSTSQDSNNNDLLSTWHSNTYVKLISQIARQTTTNECWICANAPSHLHSGIPFLGVPLTLEQHLSADVRSWNLTAVNLTHQYIYLTGPTTGDLCRKFSGNDKVIGESTCKYTLDITLSGRITLWHQGNPSTHLTLLSAWKRVMNLPDSWDPSPISQCFFRTFHTGRIDSCLQGLFWICGHRGYTWASPHSRGTCYLGLILPGVRVTQELPPGKRRNKRAKDLSELSDVAANGETYGRALFPAYGAGSNHVDILKLTDILLNFMEESNAATQSILTELTEVRQNSIQNRLALDYVLASTGGVCALIGTECCTHPSVNKEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUL7</accession>
    <name>A0A670IUL7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MutS homolog 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IUL7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016244.1">
        <property type="protein sequence ID" value="ENSPMRP00000015204.1"/>
        <property type="gene ID" value="ENSPMRG00000010140.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074897"/>
    <dbReference type="OMA" id="GAMANIN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03243">
        <property type="entry name" value="ABC_MutS_homologs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="359" mass="40927" checksum="C192CDF036D125BD" modified="2020-06-17" version="1">MNERCQESLREIYHMTYLIVCKLLSEIYEHIHCLYKLSDAVSMLDMLQSFAHACTLSDYVRPEFTDTLAIKEGWHPVLEKISFEKPVANNTYITEGSNFIIITGPNMSGKSTYLKQIALSQIMAQIGSFVPAEYSSFRIAEQIFTRIGMDDDIETNSSTFMKEMKEIAYIIQNANDRSLIIIDELGRGTSAEEGIGICYAVCEYLLNLKAFTLFATHFLELCQIDALYPNVENNYFEVQHVRSSYGSREKIAYTYVLSKGHTEEKNYGLKAAEVSSLPPSIIQDAKEIITLISRQMSQQRSTPETLMKKAIYHLANMLVQTARNSRLDPDSLRIYLKGLKKKYKTDCLAAEQVPTEDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVH4</accession>
    <name>A0A670IVH4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch like family member 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KLHL29</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028578182.1">
        <property type="nucleotide sequence ID" value="XM_028722349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IVH4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016555.1">
        <property type="protein sequence ID" value="ENSPMRP00000015499.1"/>
        <property type="gene ID" value="ENSPMRG00000010337.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000016566.1">
        <property type="protein sequence ID" value="ENSPMRP00000015510.1"/>
        <property type="gene ID" value="ENSPMRG00000010337.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593716"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50097"/>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVH9</accession>
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                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="L1 transposable element, trimerization domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE-rel"/>
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    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name evidence="16" type="primary">TSHZ2</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
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                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="16" key="2">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the teashirt C2H2-type zinc-finger protein family.</text>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="194" mass="22874" checksum="9A4D12C0D6D87FE7" modified="2020-06-17" version="1">NSFFLLEYHLKFLKGMPLAFYYMIFLIFSLFLRGLYFTIFFVFGMLTGLWLSISNIHKRRLIINHIKEVYQFYIKGILWQEGPLHQIYVRLIAQTDAYGKRYYSLIINGYRLEVLTLAALTDQFELLDSVGRRIARNLNLNFFDYEDVSTRHVIRHLPPERYDDDDDMDYGENTSESPSGSHSPFPSSPTTNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZP5</accession>
    <name>A0A670IZP5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">72 kDa type IV collagenase</fullName>
            <ecNumber evidence="4">3.4.24.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">72 kDa gelatinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Matrix metalloproteinase-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">MMP2</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.</text>
            <dbReference type="EC" id="3.4.24.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="23">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="23">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.24" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028595955.1">
        <property type="nucleotide sequence ID" value="XM_028740122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IZP5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018425.1">
        <property type="protein sequence ID" value="ENSPMRP00000017306.1"/>
        <property type="gene ID" value="ENSPMRG00000011456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602200"/>
    <dbReference type="KEGG" id="pmua:114602200"/>
    <dbReference type="CTD" id="4313"/>
    <dbReference type="GeneTree" id="ENSGT00940000158511"/>
    <dbReference type="OMA" id="CPKDSCN"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001955">
        <property type="term" value="P:blood vessel maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060346">
        <property type="term" value="P:bone trabecula formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071492">
        <property type="term" value="P:cellular response to UV-A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035987">
        <property type="term" value="P:endodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060325">
        <property type="term" value="P:face morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001957">
        <property type="term" value="P:intramembranous ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904707">
        <property type="term" value="P:positive regulation of vascular associated smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904645">
        <property type="term" value="P:response to amyloid-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048771">
        <property type="term" value="P:tissue remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000002">
        <property type="entry name" value="72 kDa type IV collagenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000004">
        <property type="entry name" value="72 kDa type IV collagenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000010">
        <property type="entry name" value="72 kDa type IV collagenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF29">
        <property type="entry name" value="72 KDA TYPE IV COLLAGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 23" id="KW-0106">Calcium</keyword>
    <keyword evidence="16" id="KW-0177">Collagen degradation</keyword>
    <keyword evidence="18 24 27" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 29" id="KW-0732">Signal</keyword>
    <keyword evidence="13 23" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025362014" description="72 kDa type IV collagenase" evidence="29">
        <location>
            <begin position="30"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="30">
        <location>
            <begin position="245"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="30">
        <location>
            <begin position="303"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="30">
        <location>
            <begin position="361"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="28">
        <location>
            <begin position="487"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="28">
        <location>
            <begin position="532"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="28">
        <location>
            <begin position="580"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="28">
        <location>
            <begin position="629"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="26">
        <location>
            <begin position="117"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="22">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="21">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="23">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <location>
            <position position="223"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
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        <ligand>
            <name>Ca(2+)</name>
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            <name>Ca(2+)</name>
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        <ligand>
            <name>Ca(2+)</name>
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            <name>Ca(2+)</name>
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        <location>
            <position position="567"/>
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        <location>
            <begin position="250"/>
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    <feature type="disulfide bond" evidence="27">
        <location>
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    <feature type="disulfide bond" evidence="27">
        <location>
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        <location>
            <begin position="484"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000178"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012372"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021167"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="675" mass="76138" checksum="591141CFEF48DB12" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J0R3</accession>
    <name>A0A670J0R3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">POU3F3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583786.1">
        <property type="nucleotide sequence ID" value="XM_028727953.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000018884.1">
        <property type="protein sequence ID" value="ENSPMRP00000017736.1"/>
        <property type="gene ID" value="ENSPMRG00000011715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596410"/>
    <dbReference type="KEGG" id="pmua:114596410"/>
    <dbReference type="CTD" id="5455"/>
    <dbReference type="GeneTree" id="ENSGT00940000163665"/>
    <dbReference type="OMA" id="PPHQGHW"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071837">
        <property type="term" value="F:HMG box domain binding"/>
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    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cerebral cortex radially oriented cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048878">
        <property type="term" value="P:chemical homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021869">
        <property type="term" value="P:forebrain ventricular zone progenitor cell division"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0072240">
        <property type="term" value="P:metanephric DCT cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:metanephric loop of Henle development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0072227">
        <property type="term" value="P:metanephric macula densa development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072233">
        <property type="term" value="P:metanephric thick ascending limb development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071918">
        <property type="term" value="P:urea transmembrane transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016362">
        <property type="entry name" value="TF_POU_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF125">
        <property type="entry name" value="POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002629">
        <property type="entry name" value="Transcription_factor_POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="13">
        <location>
            <begin position="269"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="359"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="361"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="455" mass="47670" checksum="36B8FF3EE7F09902" modified="2020-06-17" version="1">MATAASNPYLATNSILSAGSIVHSDGGGGMQPGSVAVTSVSGGGYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEAGSPWASSPVGMTGSPQQQQQQQQQQQQQQQQPDVKGGGGGGGGRDDLHSGAALHHRPPHLGPPHQGHWGSGAGAHLPSMASQQQQQPLLYSQPGGFTVNGMLSPPPGSQSLVHPGLVRGDTPELGEHPGHHHHHHHHPHPHPHHGGGGGGGGGGGGGGGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGNVNSDTPPPHHGLQASVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J172</accession>
    <name>A0A670J172_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibroblast growth factor</fullName>
            <shortName evidence="2">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FGF11</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028558928.1">
        <property type="nucleotide sequence ID" value="XM_028703095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J172"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019404.1">
        <property type="protein sequence ID" value="ENSPMRP00000018243.1"/>
        <property type="gene ID" value="ENSPMRG00000012011.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582241"/>
    <dbReference type="KEGG" id="pmua:114582241"/>
    <dbReference type="CTD" id="2256"/>
    <dbReference type="GeneTree" id="ENSGT00940000158058"/>
    <dbReference type="OMA" id="LYCSPHF"/>
    <dbReference type="OrthoDB" id="6158176at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23309">
        <property type="entry name" value="beta-trefoil_FGF11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000001">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="242" mass="27040" checksum="C51718A4F9CC53ED" modified="2020-06-17" version="1">MAALASSLIRQKREIRDPVASRPVSTQRKVCPRGTKSLCQKQLLILISKVRLCGGRKGRLEKTPEPQLKGIVTKLFCRHGYYLQVHPDGSIDGTREDTNGFTLFNLIPVGLRVVAIQSTKSGQYVAMNAEGYLYTSTHFTAECRFKECVFENYYVMYSSTLYRQRESGRSWYLGINKDGQVMKGNRVKKTKAAAHFLPKLLEVALYREPSLHNVVEPVLAKKAEEAGAAAAPVKEISKAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4L3</accession>
    <name>A0A670J4L3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Steroid 5 alpha-reductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SRD5A1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J4L3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020663.1">
        <property type="protein sequence ID" value="ENSPMRP00000019463.1"/>
        <property type="gene ID" value="ENSPMRG00000012693.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182886"/>
    <dbReference type="OMA" id="PHYALEW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF57">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="114"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="241" mass="26477" checksum="A51F78D1934C58C3" modified="2020-06-17" version="1">KDPGPNAECCARSRLLEGMSYGMVGSMALAMLATRYLKIPYGRYASSAYGPPIPAKVAWALQEAPALLVPMGLVWGSDGARLGFWPNRFLLALFGIHYTYRAFIFPFLIRGGKPTPAIAFLLAFVFCAYNGYLQGRSLSNYAEYSSDWPTVLRFSGWLSGLLINVHSDNILRNLRKPGETGYKIPRGGMFEYVTGANYFGEILEWCGFALAACTLESAAFAVSTSLILGRRRDFPTSSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5D9</accession>
    <name>A0A670J5D9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized LOC114583321</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC114583665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J5D9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020968.1">
        <property type="protein sequence ID" value="ENSPMRP00000019738.1"/>
        <property type="gene ID" value="ENSPMRG00000012887.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234859"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025541287" evidence="1">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="366" mass="41864" checksum="BC2597EFC02E9E52" modified="2020-06-17" version="1">MEQILLFLLVCICEQGLSASAPKEVHGILPKSKTKGIDFCGVDKYYYIIRSDLGCYLRSNDFHAGKNLEIFGLHNSVRGGDHYLADKDDFFYIIKGNSYRRVTNLNTDDDSKTYTLHRNCQNGDHYFSFDKYFFIIFKKRGWYRRVTNMQTDQNAIESTLHPKLKDGLYYWGINNKIYLVKPNNNWGVEFYRVEDMMNKNPSTISFHANVLNFLPGGVSINHGKAFGVWQSVKTVRNDAKISVAWEQQITKKVGYEKKEMHSMERNWRVSSSVTVGAEGLTKLLLAAQFSLSAQYGGKSIDSTEETWSDATEVSEKVNFTLPPNTNIYFWQYKLGLGKDDVLYCRDLAFTDNSNPPTYVPLPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J734</accession>
    <name>A0A670J734_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Leukotriene B4 receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LTB4R2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chemokine-like receptor (CMKLR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J734"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021542.1">
        <property type="protein sequence ID" value="ENSPMRP00000020288.1"/>
        <property type="gene ID" value="ENSPMRG00000013209.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182966"/>
    <dbReference type="OMA" id="ICEPCHS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004875">
        <property type="term" value="F:complement receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001632">
        <property type="term" value="F:leukotriene B4 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051546">
        <property type="term" value="P:keratinocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="7tmA_LTB4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000109">
        <property type="entry name" value="Leukotriene B4 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000826">
        <property type="entry name" value="Formyl_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003981">
        <property type="entry name" value="Leukotriene_B4_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225">
        <property type="entry name" value="CHEMOTACTIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01476">
        <property type="entry name" value="LTBRECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="40"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="361" mass="39600" checksum="893FA3B9C6DF5878" modified="2020-06-17" version="1">IGATNNCTHTSGNSTLLSSPTSSVTGIVFLLLAALIGLPGNLFVIWSILWKMKPSHRSVTCLLVVNLAVADGVVLLLTPFFIIFLIFKNWLFSLAVCKGVYYLCCINMFASIFIITLMSVDRCLAVNQPYFSQAIRKKHLVVKILSGIWVAAILLSIPALLFRQVVKDPSGRYICEPCHPRPSLTIFHFTLETVVAFVIPFTIIVGCYSAVLIRLRGVKRRQGARTEKLIVAIVICFAVLWVPYHIVNVLQVASNLSSGRTAERLGQAWKSGRAGATALAFLSSSINPVLYVFVAGNLIKTSGANFIAQFFEGASDGLGRRSHSGLTAAPWGLKQCVSPAWLRDAQHSIWDLLYTKHVLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J7K3</accession>
    <name>A0A670J7K3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F-box/WD repeat-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FBXW7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J7K3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020441.1">
        <property type="protein sequence ID" value="ENSPMRP00000019252.1"/>
        <property type="gene ID" value="ENSPMRG00000012582.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154986"/>
    <dbReference type="OMA" id="QGSEYPR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990452">
        <property type="term" value="C:Parkin-FBXW7-Cul1 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
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        <property type="match status" value="7"/>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="455"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="895" mass="100781" checksum="B4C707D9302263B7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J932</accession>
    <name>A0A670J932_PODMU</name>
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        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ATP6V0A4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="GOC"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0051117">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0097254">
        <property type="term" value="P:renal tubular secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="V-ATPase_116kDa_su"/>
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        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF26">
        <property type="entry name" value="V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
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    </dbReference>
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        <property type="entry name" value="V_ATPase_I"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="833" mass="95053" checksum="C783EED3D2355532" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC25</accession>
    <name>A0A670JC25_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCO-spondin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thrombospondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000023189.1">
        <property type="protein sequence ID" value="ENSPMRP00000021846.1"/>
        <property type="gene ID" value="ENSPMRG00000014119.1"/>
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        <property type="component" value="Chromosome 12"/>
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    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="Adhesion G protein-coupled receptor B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="Unc-5 netrin receptor C"/>
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        <property type="entry name" value="Complement Module, domain 1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
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        <property type="entry name" value="LDL_receptor-like_sf"/>
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        <property type="entry name" value="LDLR_class-A_CS"/>
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        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
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        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
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        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
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    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
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        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF396">
        <property type="entry name" value="SCO-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
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        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFD" evidence="17">
        <location>
            <begin position="183"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="17">
        <location>
            <begin position="523"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="17">
        <location>
            <begin position="972"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="16">
        <location>
            <begin position="2041"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="15">
        <location>
            <begin position="2147"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1562"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1572"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1374"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1381"/>
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    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1393"/>
            <end position="1408"/>
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    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1413"/>
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    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1420"/>
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    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1453"/>
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    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1472"/>
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    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
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    <feature type="disulfide bond" evidence="13">
        <location>
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    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
        <location>
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    <feature type="disulfide bond" evidence="13">
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    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
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    <feature type="disulfide bond" evidence="13">
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    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="2476"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009456"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020523"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045981"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="5197" mass="563115" checksum="B8E698073DE5CEFB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEE1</accession>
    <name>A0A670JEE1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SSU72</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 10">Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028596711.1">
        <property type="nucleotide sequence ID" value="XM_028740878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JEE1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023332.1">
        <property type="protein sequence ID" value="ENSPMRP00000021969.1"/>
        <property type="gene ID" value="ENSPMRG00000014290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602535"/>
    <dbReference type="KEGG" id="pmua:114602535"/>
    <dbReference type="CTD" id="29101"/>
    <dbReference type="GeneTree" id="ENSGT00390000010165"/>
    <dbReference type="OMA" id="PNCYEFG"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000066">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase SSU72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="194" mass="22601" checksum="2CF9CFBC0A0B7B8C" modified="2020-06-17" version="1">MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFIVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDVFDLILTCEERVYDQVVEDLNSREQETCQPVHVINVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEP4</accession>
    <name>A0A670JEP4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Cell membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the sodium channel (TC 1.A.1.10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000023991.1">
        <property type="protein sequence ID" value="ENSPMRP00000022575.1"/>
        <property type="gene ID" value="ENSPMRG00000012593.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154224"/>
    <dbReference type="OMA" id="ISVIPXH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13433">
        <property type="entry name" value="Na_channel_gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000002">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000001">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000003">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000006">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000002">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000004">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000005">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000001">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000003">
        <property type="entry name" value="Voltage-dependent sodium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058542">
        <property type="entry name" value="IQ_SCN5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001696">
        <property type="entry name" value="Na_channel_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044564">
        <property type="entry name" value="Na_chnl_inactivation_gate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010526">
        <property type="entry name" value="Na_trans_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024583">
        <property type="entry name" value="Na_trans_cytopl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF278">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24609">
        <property type="entry name" value="IQ_SCN5A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06512">
        <property type="entry name" value="Na_trans_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11933">
        <property type="entry name" value="Na_trans_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00170">
        <property type="entry name" value="NACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 19" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 19" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="16 19" id="KW-0739">Sodium transport</keyword>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="856" mass="95602" checksum="DAAED5AA58F879D3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JIT9</accession>
    <name>A0A670JIT9_PODMU</name>
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        <submittedName>
            <fullName evidence="15">Zinc finger protein 668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF668</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028559980.1">
        <property type="nucleotide sequence ID" value="XM_028704147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JIT9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026248.1">
        <property type="protein sequence ID" value="ENSPMRP00000024733.1"/>
        <property type="gene ID" value="ENSPMRG00000015991.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582832"/>
    <dbReference type="KEGG" id="pmua:114582832"/>
    <dbReference type="CTD" id="79759"/>
    <dbReference type="GeneTree" id="ENSGT00940000165156"/>
    <dbReference type="OMA" id="WDEVQAH"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000226">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000495">
        <property type="entry name" value="zinc finger protein 668"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000643">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000973">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001203">
        <property type="entry name" value="zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001443">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001638">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001442">
        <property type="entry name" value="zinc finger protein 696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF157">
        <property type="entry name" value="ZINC FINGER PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="611" mass="68912" checksum="183E4AFAE08478FF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJ88</accession>
    <name>A0A670JJ88_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G protein-coupled receptor 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPR27</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="OMA" id="FIHSHRK"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900738">
        <property type="term" value="P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="7tmA_SREB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="probable G-protein coupled receptor 173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051509">
        <property type="entry name" value="GPCR_Orphan/Phoenixin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19268">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19268:SF8">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 27-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="49"/>
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        <source>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="380" mass="42647" checksum="BFFD269DD36AB99C" modified="2020-06-17" version="1">LDREPRPPARVVAARSPFPSAASGLKLTTLGLILCLSLAGNGLFAWLILKERPLHRAPYYLLLDLCLADGLRSLACFPFVMLSVHSGAGAWPHGALSCKVLAFLAVLFCFHAAFLLFCVGVTRYMAIAHHRFYAKRMTGWTCLAVVCMVWTLSMAMAFPPVFDVGTYKFIREEEQCIFEHRYVKANDTLGFMLMLATVVAATHLVYVKLLFFIHSHRKMKPAQLVPAISQNWTFHGPGATGQAAANWTAGFGRGPTPPTLVGIRQNTTHSQIKRLLVLEEFKTEKRICKMFYMITLLFLLLWSPYIVACYLRVFIKASAIPQVYLTTSVWMTFAQAGVNPILCFIFNKELRVCFRAHFLCCQSIQNTQGTILCDLKNFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKF9</accession>
    <name>A0A670JKF9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JKF9"/>
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    </dbReference>
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            <end position="597"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="796" mass="90988" checksum="5E6BF8D0227EEF16" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JL68</accession>
    <name>A0A670JL68_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JL68"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027340.1">
        <property type="protein sequence ID" value="ENSPMRP00000025758.1"/>
        <property type="gene ID" value="ENSPMRG00000016677.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00670000098452"/>
    <dbReference type="OMA" id="FITIPHC"/>
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        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="33"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="330" mass="37417" checksum="C04F9E4CB15E8FB1" modified="2025-10-08" version="2">MEGCWADNGENSFDLVLSLAAPQLTISLISVLFNSAVIFAVVYSKELRKPIFILFCNMAFSDLFTSSTGFWIALLFITNPQSTISGSKELLTAYAFYTMSILATIYNLVLIGIERYLAVAECLRRRWRLGRNQILGMVLGVWGLSFFLGFLPLMGWNCLDRDNASALYSPLCIDYLIFITIPHCAVVLILPFFTYCNIIGFLRKHKMAMGALGQTHATYRLAEIQVARTSIFIWLLSLLSYTPFFAGVVLDITTQQCPNNFSMDVYVFRNLTAIMITMNSLGNPIIYTLKVKTLWHRLRFLKCPSSNRIEVQAIGKILVRFHPNIFKCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLB3</accession>
    <name>A0A670JLB3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xin actin binding repeat containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">XIRP2</name>
    </gene>
    <organism evidence="7 8">
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <source>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="391" mass="44463" checksum="E13240A1ABF06D63" modified="2020-06-17" version="1">MKASPRSRSGDEMWQGNFMGTLVLLLVTLIGAVRGATLTLPRPSNVSYTLNETRCQLDVVWTPVRMEGACDVKYQSAITTDGVWDVERIHTNHSRTVQVPLGKEVVFGVRTKCQQEQSQKGEWLNISLPQNGVPGTGAVNVSCVWQMERSLECSWLRGENASRDANYSLTLWIPELRREQPCTNYTKQGGAFRCAFDLKYQWIELSISLQGNSKDIQPVCILSKMSGKGRFPVRLKTPSIVNITKNNGGVFLNWTKPSLWSNMNYEVEINNSGRPDIQPTHNTNISISLKPKAHHTFRVRAKFYSSGEIWTSDWSEVVDWDERDHTLYIPYILAPLCVAVLTVIFLIYRKRIKEMILPTIPEPRNFLEQMFDGESEDYSKVKSVPEDPKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPB6</accession>
    <name>A0A670JPB6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WW domain binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">WBP1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028600434.1">
        <property type="nucleotide sequence ID" value="XM_028744601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JPB6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026869.1">
        <property type="protein sequence ID" value="ENSPMRP00000025314.1"/>
        <property type="gene ID" value="ENSPMRG00000016385.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604478"/>
    <dbReference type="KEGG" id="pmua:114604478"/>
    <dbReference type="CTD" id="23559"/>
    <dbReference type="GeneTree" id="ENSGT00950000183109"/>
    <dbReference type="OMA" id="CNNKEEQ"/>
    <dbReference type="OrthoDB" id="9907279at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021684">
        <property type="entry name" value="WBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051994">
        <property type="entry name" value="WW_domain-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16209">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16209:SF5">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11669">
        <property type="entry name" value="WBP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="328" mass="35255" checksum="33D951A5E8E14411" modified="2020-06-17" version="1">MERRRPPPGREAQAGWAALLGRERQAREFCPGVNDQPYVCETGHCCGETGCCIYYYELWWFWLLWTVLILFSCCCAYRHRRAKLRLQQQQRQREINLIAYHGACNYPPSMMDLRMLASFKLPAYEEVAHRPTTPPPPYSAILGGSASRLGSSTLTLTGSSENYTSCSCESSCLTSPSSTSLSATEASTPSEGEADAEGAGGGSSSPGGSWELAGKLAPCPAPPKHALFSSSVELFEGDSRRVSDSDEGPDDEGEHFRHRRLTGDSGIEVGRGQDEEEAAGEDSEEEAAHLLAKGVPCSPPGSEAQSLCAGQAEGDPEELAASSPTLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQB4</accession>
    <name>A0A670JQB4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease HTRA2, mitochondrial</fullName>
            <ecNumber evidence="5">3.4.21.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">HTRA3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.</text>
            <dbReference type="EC" id="3.4.21.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.108" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670JQB4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026715.1">
        <property type="protein sequence ID" value="ENSPMRP00000025172.1"/>
        <property type="gene ID" value="ENSPMRG00000016288.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159570"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06785">
        <property type="entry name" value="cpPDZ_HtrA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.120:FF:000004">
        <property type="entry name" value="Serine protease HTRA2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF14">
        <property type="entry name" value="SERINE PROTEASE HTRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="PDZ" evidence="18">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="143"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="516" mass="54804" checksum="BF4620FFFD9C2759" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRN5</accession>
    <name>A0A670JRN5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kelch like family member 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KLHL40</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">A band</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">I band</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KLHL40 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028606734.1">
        <property type="nucleotide sequence ID" value="XM_028750901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JRN5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029357.1">
        <property type="protein sequence ID" value="ENSPMRP00000027678.1"/>
        <property type="gene ID" value="ENSPMRG00000017856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607575"/>
    <dbReference type="KEGG" id="pmua:114607575"/>
    <dbReference type="CTD" id="131377"/>
    <dbReference type="GeneTree" id="ENSGT00940000156360"/>
    <dbReference type="OMA" id="RNFACER"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18516">
        <property type="entry name" value="BACK_KLHL40_KBTBD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18340">
        <property type="entry name" value="BTB_POZ_KLHL40_KBTBD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000006">
        <property type="entry name" value="Kelch repeat and BTB domain-containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000037">
        <property type="entry name" value="Kelch-like family member 40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030607">
        <property type="entry name" value="KLHL40_BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF22">
        <property type="entry name" value="KELCH-LIKE PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="622" mass="70320" checksum="54FDF4DD742BA954" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSA7</accession>
    <name>A0A670JSA7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">YWHAH</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JSA7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028389.1">
        <property type="protein sequence ID" value="ENSPMRP00000026755.1"/>
        <property type="gene ID" value="ENSPMRG00000017297.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000028395.1">
        <property type="protein sequence ID" value="ENSPMRP00000026760.1"/>
        <property type="gene ID" value="ENSPMRG00000017297.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282547"/>
    <dbReference type="OMA" id="KNCDESQ"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150048">
        <property type="term" value="C:cerebellar granule cell to Purkinje cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006713">
        <property type="term" value="P:glucocorticoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050774">
        <property type="term" value="P:negative regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042921">
        <property type="term" value="P:nuclear receptor-mediated glucocorticoid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099171">
        <property type="term" value="P:presynaptic modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
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        <location>
            <position position="57"/>
        </location>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="247" mass="28279" checksum="9211FC6E5C466524" modified="2020-06-17" version="1">MSDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLALLDKFLIKNCSDIQYESKVFYLKMKGDYYRYLAEVAAGEKKNSVVEASEAAYKEAFEISKEHMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVU3</accession>
    <name>A0A670JVU3_PODMU</name>
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        <recommendedName>
            <fullName evidence="5">Keratin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avian keratin family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Keratin"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0416">Keratin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="16864" checksum="30BAF178820A39AB" modified="2020-06-17" version="1">MERKTHLHPTMVDCGPSCAVPSCASTPTVGFGSAGGLGYGGLGYGLGGLGYGNGGFGYGFGGLGYGYGGAERAANLGVLAGVVPSCINQIPPAEVVVQPPACVLTIPGPILSASCEPVAVGGNTPCAVGGSGIVGGYGYGGLGFGSGLLGSSGGFGYGLGYGRGRKFGRRFSICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWP5</accession>
    <name>A0A670JWP5_PODMU</name>
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        <submittedName>
            <fullName evidence="12">G protein-coupled receptor 176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPR176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028578056.1">
        <property type="nucleotide sequence ID" value="XM_028722223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JWP5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030627.1">
        <property type="protein sequence ID" value="ENSPMRP00000028871.1"/>
        <property type="gene ID" value="ENSPMRG00000018668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593661"/>
    <dbReference type="KEGG" id="pmua:114593661"/>
    <dbReference type="CTD" id="11245"/>
    <dbReference type="GeneTree" id="ENSGT00950000182998"/>
    <dbReference type="OMA" id="VTDIYAM"/>
    <dbReference type="OrthoDB" id="9339792at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15006">
        <property type="entry name" value="7tmA_GPR176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043523">
        <property type="entry name" value="GPCR_176_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="74"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="527" mass="58630" checksum="48DD5368888B0800" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZ20</accession>
    <name>A0A670JZ20_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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    <dbReference type="Ensembl" id="ENSPMRT00000029832.1">
        <property type="protein sequence ID" value="ENSPMRP00000028117.1"/>
        <property type="gene ID" value="ENSPMRG00000018155.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000243977"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="58" mass="5810" checksum="0332E96FF99E7373" modified="2020-06-17" version="1">MPKVVDSSGKTQSKDIAKSSVPSGPVATDKSGSITISVHAKPGSKQNAVTGMLEVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZQ5</accession>
    <name>A0A670JZQ5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translocon-associated protein subunit beta</fullName>
            <shortName evidence="11">TRAP-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SSR2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAP-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566226.1">
        <property type="nucleotide sequence ID" value="XM_028710393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028566227.1">
        <property type="nucleotide sequence ID" value="XM_028710394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JZQ5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030545.1">
        <property type="protein sequence ID" value="ENSPMRP00000028794.1"/>
        <property type="gene ID" value="ENSPMRG00000018621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586688"/>
    <dbReference type="KEGG" id="pmua:114586688"/>
    <dbReference type="CTD" id="6746"/>
    <dbReference type="GeneTree" id="ENSGT00390000005125"/>
    <dbReference type="OMA" id="ILWHSSK"/>
    <dbReference type="OrthoDB" id="5860827at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008856">
        <property type="entry name" value="TRAP_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016400">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025505124" description="Translocon-associated protein subunit beta" evidence="13">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="183" mass="20143" checksum="B710C0083A00CCA4" modified="2020-06-17" version="1">MKLLILAVLVATSSVYCEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALEVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHMVVLRPLKAGYFNFTSATITYLAQEGAQVVVGFTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2B9</accession>
    <name>A0A670K2B9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 319</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF319</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028595226.1">
        <property type="nucleotide sequence ID" value="XM_028739393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028595227.1">
        <property type="nucleotide sequence ID" value="XM_028739394.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028595228.1">
        <property type="nucleotide sequence ID" value="XM_028739395.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028595229.1">
        <property type="nucleotide sequence ID" value="XM_028739396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K2B9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033612.1">
        <property type="protein sequence ID" value="ENSPMRP00000031688.1"/>
        <property type="gene ID" value="ENSPMRG00000020531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601837"/>
    <dbReference type="KEGG" id="pmua:114601837"/>
    <dbReference type="CTD" id="57567"/>
    <dbReference type="GeneTree" id="ENSGT00940000160309"/>
    <dbReference type="OMA" id="QHHSAHT"/>
    <dbReference type="OrthoDB" id="8895262at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000250">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000185">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001217">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001233">
        <property type="entry name" value="Zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001238">
        <property type="entry name" value="Zinc finger protein 648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001134">
        <property type="entry name" value="Zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="410"/>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="493"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="947" mass="108466" checksum="B3B04C09F70BB983" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4D2</accession>
    <name>A0A670K4D2_PODMU</name>
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        <recommendedName>
            <fullName evidence="10">Solute carrier family 25 member 43</fullName>
        </recommendedName>
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    <gene>
        <name evidence="14" type="primary">SLC25A43</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028570763.1">
        <property type="nucleotide sequence ID" value="XM_028714930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K4D2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032364.1">
        <property type="protein sequence ID" value="ENSPMRP00000030514.1"/>
        <property type="gene ID" value="ENSPMRG00000019754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589015"/>
    <dbReference type="KEGG" id="pmua:114589015"/>
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    <dbReference type="GeneTree" id="ENSGT00940000160686"/>
    <dbReference type="OMA" id="QSFMCVG"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial substrate carrier family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
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    </dbReference>
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        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
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    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="103"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="198"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSPMRP00000030514.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="332" mass="36751" checksum="175992DB1A93A22F" modified="2020-06-17" version="1">MATWKRDSRLTALQRLSCAGLAGALSHSLTAPLEVFTVLAQVGTHHSRRGLWETGRSLCKAEGIGALWKGNLTACLRLFPYSALQLASYRRFVLLFVDDLGHISQWGSIMAGSLAGMVAAVATYPTEVVKTRLIVQNRLEPSYKGILHALYMIYHQEGVAALYRGVSLSVLGAIPFSIGSFLVYTHLDKIWGQPSIRFTPVQNFVNGCLAAGVAQTLSFPFETVKRKMQAQSPCLPHHGGVDVHFAGMVDCFKQTVKTKGVLALWNGLTANLLRIVPYFGVMFSTFEFCRRVCLYRNGYIDSPLTYKLTPGVDQSLKPKELQEFKLLGRRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5H1</accession>
    <name>A0A670K5H1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hsp90 co-chaperone Cdc37-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CDC37L1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K5H1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034744.1">
        <property type="protein sequence ID" value="ENSPMRP00000032768.1"/>
        <property type="gene ID" value="ENSPMRG00000021219.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013443"/>
    <dbReference type="OMA" id="YAAKCRN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Hsp90 co-chaperone Cdc37-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF2">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="99"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="297" mass="34669" checksum="111082DA8E913A5A" modified="2020-06-17" version="1">SACLQFGFFLTQIYDGIELACQQQKEFVKSSVECKWNLAEAQQKLGSLALHNSESMDQENAKAQTEAAELKWREEEWRRKEEVLRQKERQELWNTDFVSKEVFNKSFINQMKRKETEDDASKSFMQKHEQKIRHFGMLSRWLDSQRFLSEHPYLVCEETAQYLLLWCFHLEAEQKGALMEQVAHQAVVMQFIIEMAKSCNVDPRGCFRLFFQRAKTGEEGYLEAFKNELEAFKSRVRFCSQSQNFQANPAQNPSFYPDFNCIGGLASFPQNADSLQGCSLNSVVHRDEDEPKMMDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5P5</accession>
    <name>A0A670K5P5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Taste receptor type 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor T2R family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K5P5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034097.1">
        <property type="protein sequence ID" value="ENSPMRP00000032156.1"/>
        <property type="gene ID" value="ENSPMRG00000020851.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286961"/>
    <dbReference type="OMA" id="NWRIFMN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033038">
        <property type="term" value="F:bitter taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13950">
        <property type="entry name" value="7tm_TAS2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007960">
        <property type="entry name" value="TAS2R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394:SF47">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2 MEMBER 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05296">
        <property type="entry name" value="TAS2R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="3 12" id="KW-0919">Taste</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="316" mass="36201" checksum="DACE1AA974D95F0F" modified="2020-06-17" version="1">MGMPTLFELFGFVLLVIETLIGMVGNGFIAIVNCIDWFRSRKVSPADMILSCLSLFRFAFLATVIQTAIINLFFVDPFLMLKIKIAYDSSWVFLNTANLWFASWLSVLYCVKIVNFSHPLFLQMKRRFPGLVPWMLLGTVVFSAISINTSSSCKFLNLLYVVPDFFPFTIFLFSSILLLMSLWRHKNLLQNSARDVSIEAHLNAIKALASFSVLYISKIFVEILSIVLFRMGIYDIGVYFIFLNVMAAYSSGHALILIFISPKLKQESVRMLHQLRRKEGRKEGRKECTIVSRLNSKCSTNVGFFLVLCFTFRYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5Q9</accession>
    <name>A0A670K5Q9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAU2 chromatid cohesion factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cohesin loading complex subunit SCC4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MAU2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K5Q9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034850.1">
        <property type="protein sequence ID" value="ENSPMRP00000032853.1"/>
        <property type="gene ID" value="ENSPMRG00000021003.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012198"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000604">
        <property type="entry name" value="MAU2 sister chromatid cohesion factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="612" mass="68394" checksum="78E1222CE2DF2B60" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6F9</accession>
    <name>A0A670K6F9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger protein 711</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF711</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C. May compete with transcription factor ARX for activation of expression of KDM5C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with PHF8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028570396.1">
        <property type="nucleotide sequence ID" value="XM_028714563.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028570397.1">
        <property type="nucleotide sequence ID" value="XM_028714564.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028570398.1">
        <property type="nucleotide sequence ID" value="XM_028714565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K6F9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033113.1">
        <property type="protein sequence ID" value="ENSPMRP00000031214.1"/>
        <property type="gene ID" value="ENSPMRG00000020229.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588866"/>
    <dbReference type="KEGG" id="pmua:114588866"/>
    <dbReference type="CTD" id="7552"/>
    <dbReference type="GeneTree" id="ENSGT00940000159611"/>
    <dbReference type="OMA" id="QEDDISC"/>
    <dbReference type="OrthoDB" id="3561125at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903706">
        <property type="term" value="P:regulation of hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000054">
        <property type="entry name" value="Zinc finger protein 711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000179">
        <property type="entry name" value="Zinc finger protein 711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000209">
        <property type="entry name" value="Zinc finger protein 711"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000170">
        <property type="entry name" value="Zinc finger protein 711 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006794">
        <property type="entry name" value="Transcrp_activ_Zfx/Zfy-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="ZINC FINGER Y-CHROMOSOMAL PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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        <property type="entry name" value="Zfx_Zfy_act"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
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        <location>
            <begin position="518"/>
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        <location>
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        <location>
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        <location>
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            <begin position="746"/>
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        <location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069176"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031214.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="803" mass="90447" checksum="B99910B05716030C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7T5</accession>
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        <recommendedName>
            <fullName evidence="4">Glutamate ionotropic receptor delta type subunit 2</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <begin position="73"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11531" checksum="E93015B46E7AAA61" modified="2020-06-17" version="1">MCTALNYSHAFFLGAIFDESAKKDEEVFRMAVSDLNQNDEILQTEKITISVNFVDGNNPFQAVQEGRLSEGGIFYSLCFGIDTYFWIVVSLIICIQAKHIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8C5</accession>
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            <fullName evidence="14">CCR4-associated factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CNOT3</name>
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    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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                <person name="Salvi D."/>
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                <person name="While G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="15">Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT2. Interacts with TIP120B and NANOS2. Interacts with EBF1. Interacts in an RNA-independent manner with BICC1 (via KH domains).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K8C5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034547.1">
        <property type="protein sequence ID" value="ENSPMRP00000032580.1"/>
        <property type="gene ID" value="ENSPMRG00000020946.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014743"/>
    <dbReference type="OMA" id="NHYPHAP"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:P-body"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="18">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="19">
        <location>
            <begin position="588"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="240"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="328"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
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</entry>
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</entry>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="entry name" value="RNA BINDING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="121" mass="13655" checksum="E17BA7CA478074E2" modified="2020-06-17" version="1">GKRKGNLSVPLFLARSSLLLFEPMKEPDAIKLFIGQIPRNLEEKDLKPIFEQFGKIYELTVIKDKYTGMHKGCAFLTYCARESALKAQSALHEQKTLPGVSCLRHLPWVVSTRGKASNLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBI8</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KBI8"/>
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        <property type="protein sequence ID" value="ENSPMRP00000034161.1"/>
        <property type="gene ID" value="ENSPMRG00000022166.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="62" mass="6942" checksum="0241AC35107E2B05" modified="2020-06-17" version="1">MTSCLHSNQPNLLAFVLAEAATRTYYLGIVEENWDYAPSGENLITGQNLTEDDDLKMHRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KC95</accession>
    <name>A0A670KC95_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ISYNA1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A670KC95"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037205.1">
        <property type="protein sequence ID" value="ENSPMRP00000035088.1"/>
        <property type="gene ID" value="ENSPMRG00000022714.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018395"/>
    <dbReference type="OMA" id="VYVPMKE"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000171">
        <property type="entry name" value="inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="17">
        <location>
            <begin position="393"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="624" mass="68468" checksum="17DBC6694BDE8A62" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KD58</accession>
    <name>A0A670KD58_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 6C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytochrome c oxidase polypeptide VIc</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114600380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028592241.1">
        <property type="nucleotide sequence ID" value="XM_028736408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KD58"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034728.1">
        <property type="protein sequence ID" value="ENSPMRP00000032752.1"/>
        <property type="gene ID" value="ENSPMRG00000021224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600380"/>
    <dbReference type="KEGG" id="pmua:114600380"/>
    <dbReference type="GeneTree" id="ENSGT00940000167005"/>
    <dbReference type="OMA" id="KNYDAMK"/>
    <dbReference type="OrthoDB" id="10051322at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22901">
        <property type="entry name" value="CcO_VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051389">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="77" mass="8647" checksum="B8F8DFF78C6D4B0A" modified="2020-06-17" version="1">MSAALLPKPQMRGLLASRLRKHIVVAFLFSMGCAAGYKFGVAEPRKRAYAEFYKNYDAMKEFEAMRKAGVFESAPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEV4</accession>
    <name>A0A670KEV4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine incorporator 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SERINC4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KEV4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037546.1">
        <property type="protein sequence ID" value="ENSPMRP00000035416.1"/>
        <property type="gene ID" value="ENSPMRG00000022913.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234623"/>
    <dbReference type="OMA" id="IHNFWFL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF5">
        <property type="entry name" value="SERINE INCORPORATOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="489" mass="54535" checksum="EC21BEBED05FA590" modified="2020-06-17" version="1">MVPGYCKAQICCCCGPAPCTLCCPCCPGIKVSTGTRLLYMLFHILACASCCFMLSRTVAEAIKENVPFYAVLCEHLPGGSDCDILVGYSAVYRVCFGTACFYLGQAAFLVNIKSSSNVRALLHNGFWFLKLLILVGLCAAAFFIQDQRFLRAWHLVGVCGGFAFILVQLVLITAFAHTWNKNWLTGASTDKRWYLAIFLATLGFYTIASTAYTFLYKFYTHPGGCFLNKGLLAFNGALCLLMSFISITPCVRLRQPSSSPLQASIICCYVMYLTFSALSSRPPEKGLLQYKGQNLTICFPSVSKDGMQTEDTTVAILGAGVMYACVLFACNEASMLAELFGPLWMVRIYSFEFKKASCFFCCPDKMEEEVAGQRGEQEGSPVEQQIVHGDPVVYSYSTFHFVFFLASLYVMMTLTNWFSYENAVLETTFTHGSWSTFWVKVSSGWACVLLYLWLLLGPLCLPGSRQRNNTSLRVFRRQRRNLHRISVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFG3</accession>
    <name>A0A670KFG3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ciliary microtubule associated protein 1C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CIMAP1C</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KFG3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038325.1">
        <property type="protein sequence ID" value="ENSPMRP00000036163.1"/>
        <property type="gene ID" value="ENSPMRG00000023373.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162054"/>
    <dbReference type="OMA" id="YTLHTRH"/>
    <dbReference type="OrthoDB" id="429991at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF3">
        <property type="entry name" value="OUTER DENSE FIBER PROTEIN 3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="277" mass="30590" checksum="F3CE7CBDC9C52ED4" modified="2020-06-17" version="1">MLTSRAKGAAQPVSCLSGISKHPARVPAIKKQYASISAKYKGPGPGKYGRQPLTGIKDHDFTKYAEPAYTMRVKSSERLISITESPGPCYYVDPSISRLGIWRPVSFRMVQERKRPFISCTPAPNEYYVEKIHPLEESNAPAYTMGLRTHYWVSSPNPAPNQYTLPQTLGPKLPVKPAAPCLSMASSASVWGYAKDLVRGPGPAMYTIPEPDVYLCHQPSYSISQRFASSSKNYTPGPPDYNAELVTTNKPRAPRFSLGIRHSEYSHGTPPVCLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KH90</accession>
    <name>A0A670KH90_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nipsnap homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NIPSNAP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NipSnap family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A670KH90"/>
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        <property type="gene ID" value="ENSPMRG00000023669.1"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:arachidonate secretion"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:sensory perception of pain"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Protein NipSnap homolog 2"/>
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        <property type="entry name" value="protein NipSnap homolog 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF11">
        <property type="entry name" value="PROTEIN NIPSNAP HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025408280" evidence="9">
        <location>
            <begin position="28"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="11">
        <location>
            <begin position="186"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="10">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PIRSR" id="PIRSR601211-2"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00068"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="323" mass="37431" checksum="CFA49F976E3B4E35" modified="2020-06-17" version="1">MATWACGMPARRLLLLAALRGGDPCLARGSGGGRDYSKDHESSWFRSLFVHKVDPRKDAHSNLLSKKETNHLYKIQFHNVKPECLDAYNSLTEQVLPKLHSDSDYPCDLVGNWNTWYGEQDQAVHLWRFTGGYPALVDCMNKLKQNQEYLEFRKERSKMLLSRRNQLLLEFSFWNEPLPRPGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYIVHHLWAYRDLQSREETRNAAWRKRGWDENVYYTVYVSFLVAADTASIPRNLLQFHNMIKCTIPSSDPLKDYADYGCYCGLGGSGTPVDELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIJ1</accession>
    <name>A0A670KIJ1_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">Nuclear speckle splicing regulatory protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Coiled-coil domain-containing protein 55</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NSRP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KIJ1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037581.1">
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        <property type="gene ID" value="ENSPMRG00000022919.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154049"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Nsrp1"/>
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        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31938">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31938:SF4">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025390946" description="Nuclear speckle splicing regulatory protein 1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="90"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="489" mass="57066" checksum="0532DD00A298597F" modified="2020-06-17" version="1">IPVAVCLCLMFFLIIHCWTSFLEDSNENTITFLSFLLKTKLEIQRALAEDSTVYEYDNIYDDIQQKKAESHASALAGKGEKKPKYIQNILKAAELRKKEQEKRMEKKIQKERELEGGAFDDKEAFVTSAYKKKLQERAEEEEREKREAAIEACLDVTKQKDLCGFYRHLLNQAVGEEEMPKCSLREARIKEEEPSGNSCDSKQISKNLDERTSSHIPLKAEDNPDADSDLEMDTSDEENSAKAHTNSGTAHTNSGTAHTNSGTGNKKESRSSSEERSCHQKVPSSHPEKEEGGGRKEKSGQHREKERERRHKDHEKEERSRPKNHHRRREEQDEKQRRKDRKERDDYDRDLKMWRDREERYSEWEQQEKERHKERHRERDKGAQEHKEEKQQQQQQERKSSSPGPLAKDCHRAPESDSREETPPNSERSLELKHRTSGVGAEEAEKPPESQSKFAKRSNEETVMSARDRYLARQMARVGTKSYIEKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJ37</accession>
    <name>A0A670KJ37_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Alkylated DNA repair protein alkB homolog 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALKBH7</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028568684.1">
        <property type="nucleotide sequence ID" value="XM_028712851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KJ37"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039276.1">
        <property type="protein sequence ID" value="ENSPMRP00000037091.1"/>
        <property type="gene ID" value="ENSPMRG00000023875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587950"/>
    <dbReference type="KEGG" id="pmua:114587950"/>
    <dbReference type="CTD" id="84266"/>
    <dbReference type="GeneTree" id="ENSGT00390000014585"/>
    <dbReference type="OMA" id="VEPHMKR"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990984">
        <property type="term" value="F:tRNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035513">
        <property type="term" value="P:oxidative RNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010883">
        <property type="term" value="P:regulation of lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902445">
        <property type="term" value="P:regulation of mitochondrial membrane permeability involved in programmed necrotic cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000009">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1210">Necrosis</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="14">
        <location>
            <begin position="84"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="230" mass="25937" checksum="3EB50D7869FB2979" modified="2020-06-17" version="1">MQSRCALGARRAHCAARRCAERALHGREGAPGQVAAASSEALLRRLVAGGASVVPGFLSEEEEALLAREVEAPLRRGRYQDAHWDGVIHRYRETERSHWSKESQEILQRVRDTAFPPGVPQLAQVHVLDLDKTGYIKPHIDSVKFCGCTIAGLSLLSSSVMRLVSEQNVHDWLDLLLERRSLYILRGPARYEFTHEILKDEESFFDGRKIPRERRISVICRNLPLPSTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJX6</accession>
    <name>A0A670KJX6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exosome component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EXOSC2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KJX6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038111.1">
        <property type="protein sequence ID" value="ENSPMRP00000035964.1"/>
        <property type="gene ID" value="ENSPMRG00000023223.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153596"/>
    <dbReference type="OMA" id="MNMPDGV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000022">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="246" mass="27218" checksum="CED95555F40BF8AE" modified="2020-06-17" version="1">MSLQLPLRLPVPRPRLAQSFSREAGERDKDLVAPGDTITTDPGYMRGHGTYLGGEKLIASVAGVVDRVNKLICVKALKTRYNGEVGSLSLSEEEAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLTCGASVILGNNGFIWIYPTPKQKNEEAGGFITNLEPVPLSDREVISRLRNCIVALAEQKQMLYDTSILYCYEASLSHEQIKDLLKPEVMEKIVLETRQRLLELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKC3</accession>
    <name>A0A670KKC3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <reaction evidence="13">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
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        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
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    <comment type="similarity">
        <text evidence="14">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.</text>
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        <property type="entry name" value="Acid-sensing ion channels like domains"/>
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        <property type="entry name" value="ENaC_chordates"/>
    </dbReference>
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        <property type="entry name" value="ENaC"/>
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    </dbReference>
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        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
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    </dbReference>
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        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
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        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Ensembl" id="ENSPMRP00000036169.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="490" mass="55384" checksum="119D705925919400" modified="2020-06-17" version="1">MAPAKKIKAKLKKTLPVTGPQAPTLRELMHWYCMNTNTHGCRRIVVSRGRLRRFLWILLTLTAVGLILWYCTQLVLNYYKASVSVTVQFHALPFPAVTICNINPYKYSAIKKHLAELDKETENALRSLYDFSGSNIRERRDAGDPEPSEDRRFHRYFPLMNLDNLTHQQPFPNPSSGSKRRMEANIISGGSSIVSVKNPQDIVGFQLCDSHNKSDCALYTFSSGVNAIQEWYKLHYMNIMAQISAEEKVNMSYSAEELILSCFFDGRSCDARNFTTFHHPMHGNCYTFNSGQNGSILNTTTGENGALSAVVRSEYNPFLVTSTGAKIVIHGQDEYPFIEDVRLTPTEFFLSDPQTKSKRLGYPYSNCKEDGSDVNVKKLYKNKTYSLQTCLHSCFQNEMVKKCGCAQYAQPLPDNAEFCNYKKYPDWIQCELFVAIHNFRRKHPSLGSHSSGPKPDFRQEEAPASLSPSAHICVHGLLPSCPSSSIIISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKH6</accession>
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        <recommendedName>
            <fullName evidence="3">A-kinase anchor protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KKH6"/>
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        <property type="protein sequence ID" value="ENSPMRP00000036269.1"/>
        <property type="gene ID" value="ENSPMRG00000023423.1"/>
    </dbReference>
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    <dbReference type="OMA" id="QASHRHD"/>
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        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029304">
        <property type="entry name" value="AKAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042779">
        <property type="entry name" value="MISP/MISP3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18839:SF7">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 2 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18839">
        <property type="entry name" value="MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 MISP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKAP2_C"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <begin position="305"/>
            <end position="552"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
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        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="580" mass="65673" checksum="2E852E919BF37267" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLV4</accession>
    <name>A0A670KLV4_PODMU</name>
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        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transmembrane protein 93</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EMC6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028708620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KLV4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039213.1">
        <property type="protein sequence ID" value="ENSPMRP00000037029.1"/>
        <property type="gene ID" value="ENSPMRG00000023840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585743"/>
    <dbReference type="KEGG" id="pmua:114585743"/>
    <dbReference type="CTD" id="83460"/>
    <dbReference type="GeneTree" id="ENSGT00390000003917"/>
    <dbReference type="OMA" id="MKANFEW"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:omegasome membrane"/>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <source>
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            <dbReference type="Ensembl" id="ENSPMRP00000037029.1"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="111" mass="12129" checksum="40C2EB166E9F4890" modified="2020-06-17" version="1">MANAVIAKREGPQFISEAAVRGNAAILDYCRTSVSALSGATAGILGLTGLHGFIFYFLASALLSILLVLKAGRRWSKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HKR7</accession>
    <name>A0A670HKR7_PODMU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="140" mass="15544" checksum="76C91C559E8E544B" modified="2020-06-17" version="1">EIFGMETEISLHLLDRKGCEELLEVIVMETEDLASPVLRGITLYTELDDQTFLEAEVIILLDDVLQEAIPSHEECIQQVTTQCEIYGPLIEKNARSHVRVVVMGKTFVNLKALMLITHAPSINPQNIVTVSLVGSGPIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HLE8</accession>
    <name>A0A670HLE8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Immunoglobulin superfamily member 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Chromosome 4"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="IgV"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin superfamily member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="immunoglobulin superfamily member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin superfamily member 3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Immunoglobulin superfamily member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin superfamily, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051102">
        <property type="entry name" value="IgSF_V-set/TM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12207:SF21">
        <property type="entry name" value="IMMUNOGLOBULIN SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12207">
        <property type="entry name" value="V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025430369" description="Immunoglobulin superfamily member 3" evidence="12">
        <location>
            <begin position="33"/>
            <end position="1187"/>
        </location>
    </feature>
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        <location>
            <begin position="1118"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="156"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="308"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="410"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="572"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="689"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="826"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="962"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067302"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HPM5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001886.1">
        <property type="protein sequence ID" value="ENSPMRP00000001774.1"/>
        <property type="gene ID" value="ENSPMRG00000001307.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160984"/>
    <dbReference type="OMA" id="ACKFWIS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021960">
        <property type="term" value="P:anterior commissure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061073">
        <property type="term" value="P:ciliary body morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060122">
        <property type="term" value="P:inner ear receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021670">
        <property type="term" value="P:lateral ventricle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904761">
        <property type="term" value="P:negative regulation of myofibroblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032911">
        <property type="term" value="P:negative regulation of transforming growth factor beta1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000308">
        <property type="entry name" value="tsukushin isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF352">
        <property type="entry name" value="TSUKUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025334101" description="Tsukushi" evidence="10">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="232" mass="25316" checksum="FE5AE9D9B0015A74" modified="2020-06-17" version="1">MPFLIWFNLLLLSPNVGASKTCFPGCHCEVESFGLFDSFSLTKVDCSGIGPHIVPVPIPLDTTYLDLSSNNLDSINESMLTGPGYTTLVSLDLSYNKISRIFPSTFSRLRYLESLDLSHNSLVALPDECFSGSLLGDVDLSNNFILDITTNIFASKGQGKPINVDLSNNLISLVSRHQGKAIPNIQSLNLSGNRLKKIPDLQGIPLRFRPTPSKTCQLSKRSICPTTPTSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPR1</accession>
    <name>A0A670HPR1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kindlin-2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HPR1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001621.1">
        <property type="protein sequence ID" value="ENSPMRP00000001521.1"/>
        <property type="gene ID" value="ENSPMRG00000001130.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000185782"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040790">
        <property type="entry name" value="Kindlin_2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18124">
        <property type="entry name" value="Kindlin_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kindlin-2 N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="103" mass="11218" checksum="C87069E291FAAEB9" modified="2020-06-17" version="1">IALNGINMTSSNEYGSSSWELIVAIDHQCGGEQKESTLQVSGDLHIGGVMLKLVEQISEFNDICFSVYAPTQNILVNILIWAVSSSVTIQQLFIGAHVFFWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HR40</accession>
    <name>A0A670HR40_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Death domain-associated protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Daxx</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">DAXX</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DAXX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HR40"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002142.1">
        <property type="protein sequence ID" value="ENSPMRP00000002016.1"/>
        <property type="gene ID" value="ENSPMRG00000001480.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009448"/>
    <dbReference type="OMA" id="NSPHNED"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13151">
        <property type="entry name" value="DAXX_helical_bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13150">
        <property type="entry name" value="DAXX_histone_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.810:FF:000001">
        <property type="entry name" value="Death domain-associated protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2170:FF:000001">
        <property type="entry name" value="Death domain-associated protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.810">
        <property type="entry name" value="Daxx helical bundle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046378">
        <property type="entry name" value="DAXX_histone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046426">
        <property type="entry name" value="DAXX_histone-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031333">
        <property type="entry name" value="Daxx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038298">
        <property type="entry name" value="Daxx_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12766:SF7">
        <property type="entry name" value="DEATH DOMAIN-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12766">
        <property type="entry name" value="DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03344">
        <property type="entry name" value="Daxx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20920">
        <property type="entry name" value="DAXX_hist_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="21" id="KW-0137">Centromere</keyword>
    <keyword evidence="19" id="KW-0143">Chaperone</keyword>
    <keyword evidence="15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0678">Repressor</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Daxx N-terminal Rassf1C-interacting" evidence="25">
        <location>
            <begin position="342"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Daxx histone-binding" evidence="26">
        <location>
            <begin position="574"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="654"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="24">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="758"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="783"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00029641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF20920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="987" mass="106608" checksum="886D55F1B80FA785" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRU9</accession>
    <name>A0A670HRU9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial</fullName>
            <ecNumber evidence="4 9">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LIPT2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17666"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="4 9"/>
    <dbReference type="RefSeq" id="XP_028581652.1">
        <property type="nucleotide sequence ID" value="XM_028725819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HRU9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002416.1">
        <property type="protein sequence ID" value="ENSPMRP00000002271.1"/>
        <property type="gene ID" value="ENSPMRG00000001645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595523"/>
    <dbReference type="KEGG" id="pmua:114595523"/>
    <dbReference type="CTD" id="387787"/>
    <dbReference type="GeneTree" id="ENSGT00390000006450"/>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000376">
        <property type="term" value="P:positive regulation of oxygen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000035">
        <property type="entry name" value="Putative lipoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="13">
        <location>
            <begin position="36"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="10">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="12">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="231" mass="25184" checksum="EC70921D048536A3" modified="2020-06-17" version="1">MRPPPVRVLRLGRAAYLDSLAAQGRCVRRHREASASEAPHRLLLWEPSGPVFTVGLRGLDARRASAEEERRLRALGAGFERVPRGGLATFHGPGQLVAYPVLDLRRFGLPVRGYVAALESVAVAACRRLGLPQAAALPPPCTGVWLRGRKVCAIGIHCGRHITSHGLALNCCTDLTWFDHIVPCGLEGKEVTSLSRELQRHVSVEEATEPFLAAFQEVFKCTLMEGSPTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTD1</accession>
    <name>A0A670HTD1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HTD1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002655.1">
        <property type="protein sequence ID" value="ENSPMRP00000002495.1"/>
        <property type="gene ID" value="ENSPMRG00000001804.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="ETNIMLI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="492"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1253" mass="148489" checksum="735B15C11519FE9F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HU98</accession>
    <name>A0A670HU98_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HU98"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003018.1">
        <property type="protein sequence ID" value="ENSPMRP00000002815.1"/>
        <property type="gene ID" value="ENSPMRG00000002033.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00640000091541"/>
    <dbReference type="OMA" id="ECWIGES"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="4">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="92" mass="10340" checksum="03431B3DD602F4B3" modified="2020-06-17" version="1">MESDMLQSPLLGLGEEDESDMTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIGESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUI5</accession>
    <name>A0A670HUI5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocator protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peripheral-type benzodiazepine receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TSPO</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HUI5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002942.1">
        <property type="protein sequence ID" value="ENSPMRP00000002747.1"/>
        <property type="gene ID" value="ENSPMRG00000001983.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012980"/>
    <dbReference type="OMA" id="RNTLIMH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072655">
        <property type="term" value="P:establishment of protein localization to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072656">
        <property type="term" value="P:maintenance of protein location in mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903579">
        <property type="term" value="P:negative regulation of ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000379">
        <property type="term" value="P:positive regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
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        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="TspO_MBR"/>
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    </dbReference>
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        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
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        <location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002747.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="216" mass="23960" checksum="E49C5EAFB45E422F" modified="2020-06-17" version="1">MGAPPAPFSASRPPAPWAAPSLPFPQPFRFLRAARSAEEAAAAAAAADAEMEALPSWAPAVAFTLLPNAGSIWGSRIVKKELPTWYESLEKPSWRPPNWVFPPVWGALYSSMGYGSYLVWRELGGFNEKSLVPLGLYAGNLALNWSWVPIFFGKHQTGWGLVTILLTTGAATATTTVWYHVNKTAAYLMYPYLAWLTFASVLNYRIWKDNRDKKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HW61</accession>
    <name>A0A670HW61_PODMU</name>
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        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 27</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="primary">TTC27</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Lepidosauria</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC27 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="826" mass="94572" checksum="15CC939C06FB50B1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWS5</accession>
    <name>A0A670HWS5_PODMU</name>
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            <fullName evidence="9">DNA polymerase subunit gamma-2</fullName>
        </recommendedName>
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        </alternativeName>
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        <alternativeName>
            <fullName evidence="12">PolG-beta</fullName>
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    </protein>
    <gene>
        <name evidence="15" type="primary">POLG2</name>
    </gene>
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        <lineage>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
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                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Marsik P."/>
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                <person name="While G.M."/>
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                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="7">Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits (POLG:POLG2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028712772.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000004194.1"/>
        <property type="gene ID" value="ENSPMRG00000002829.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114587905"/>
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    <dbReference type="OrthoDB" id="57698at2759"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Pol_gamma_b_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative dna polymerase subunit gamma-2 mitochondrial"/>
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        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
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    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
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        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042064">
        <property type="entry name" value="POLG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF8">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Anticodon-binding" evidence="14">
        <location>
            <begin position="402"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="495" mass="55408" checksum="D81C5F422765DCFE" modified="2020-06-17" version="1">MLPRRFVSFFSTGGGARGCGLRRVQKPVRRGWPEGERLLTGERGGPPSGRFLSGSGGPVSSSPGSADEEPRGFPEALLGLCQRRRFLRGAEGPQKLTWDSHLSGEHPGLGPLGVELRKNLAARWWESVVTSREQVLGVDGPLCRSPLASQGPPAEALLALRPRGVREMLENDQLSKEQVLGSLRKMLEASGVLRDSLLHSALQQYIECLELVNKRLPFGVAQIGVCFHPVRNNENENYMRTGESTMTSLVWYSSARTAGQWLDYWLRQRLQWWRKFAISPSSFTSSDHHDEEGRRRSNLYYNFPWGKEVIETLSNLGDNKLLQMYTGKESSLHGRDGRKNVVPHILSVSGNLDCGVLAYLCDGMQLAENASTRKKALQRKVLKLHPCLTPIKVALDMGRGPTIELRQVCKGLFNELLESGISVWPGYLETVQSSLEQLFAKYDEMSILFTILVSDTTLENGVVQLRNRDTTMKEMMHISRLKDFLTKYISAAKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWS9</accession>
    <name>A0A670HWS9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NIPA magnesium transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NIPA2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583650.1">
        <property type="nucleotide sequence ID" value="XM_028727817.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583651.1">
        <property type="nucleotide sequence ID" value="XM_028727818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HWS9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003917.1">
        <property type="protein sequence ID" value="ENSPMRP00000003655.1"/>
        <property type="gene ID" value="ENSPMRG00000002550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596348"/>
    <dbReference type="KEGG" id="pmua:114596348"/>
    <dbReference type="CTD" id="81614"/>
    <dbReference type="GeneTree" id="ENSGT00940000155651"/>
    <dbReference type="OMA" id="PMVYISI"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="360" mass="38918" checksum="6D52FB8E00ECD5EE" modified="2020-06-17" version="1">MIEGSGRYDFYIGLVLAMSSSLFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGTGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNEKLNLHGKVGCLLSVLGTTVMVIHAPQEEAVETLNEISHKLGDPGFVVFATFVVIVSLIMIFVVGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKELFAGKPVLTHPLSWILLLSLIVCVSTQINYLNRALDIFNTSLVTPIYYVFFTTSVLTCSAILFKEWQHMAVDDVIGTLSGFLTIIVGIFLLHAFKDVNFTLANLPVSLRKDDRGINGSLPNTYERFNDEESGSRVGDLQSTEGMASRRNGNLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HYI3</accession>
    <name>A0A670HYI3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stathmin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">STMN4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stathmin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HYI3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004533.1">
        <property type="protein sequence ID" value="ENSPMRP00000004247.1"/>
        <property type="gene ID" value="ENSPMRG00000002911.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000004536.1">
        <property type="protein sequence ID" value="ENSPMRP00000004250.1"/>
        <property type="gene ID" value="ENSPMRG00000002911.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234597"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030514">
        <property type="entry name" value="Stathmin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF6">
        <property type="entry name" value="STATHMIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00563">
        <property type="entry name" value="STATHMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="244" mass="27927" checksum="FDCA77DA1F7CF871" modified="2020-06-17" version="1">MLSGSFSIFSWKEASERLGAAGPGVDLARGLQAGHDLCLLGYALRQQEAHNTRHHDAGSLQRKNEGAPFRCLSSVACFLSDPLNKPSYKYEVDTVDLTWCVISDMEVIELNKRTSGQSFEVILKPPSFEGIPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAGKREHEREVIQKAIEENNNFIKTAKERLMQKMESNKENREAHLAAMLERLQEKDKHAEEVRKNKELKEEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ61</accession>
    <name>A0A670HZ61_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurogenic differentiation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NEUROD1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HZ61"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004728.1">
        <property type="protein sequence ID" value="ENSPMRP00000004432.1"/>
        <property type="gene ID" value="ENSPMRG00000003030.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:E-box binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:amacrine cell differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cerebellum development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:embryonic organ morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000675">
        <property type="term" value="P:negative regulation of type B pancreatic cell apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003326">
        <property type="term" value="P:pancreatic A cell fate commitment"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003329">
        <property type="term" value="P:pancreatic PP cell fate commitment"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of intestinal epithelial structure maintenance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023019">
        <property type="term" value="P:signal transduction involved in regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19719">
        <property type="entry name" value="bHLH_TS_NeuroD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
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    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022575">
        <property type="entry name" value="NeuroD_DUF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016637">
        <property type="entry name" value="TF_bHLH_NeuroD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF88">
        <property type="entry name" value="NEUROGENIC DIFFERENTIATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12533">
        <property type="entry name" value="Neuro_bHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015618">
        <property type="entry name" value="bHLH_NeuroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="395" mass="44366" checksum="2428CDC385FF92EB" modified="2020-06-17" version="1">MTSFSSPNLRFCFCVKACEAQRHKKYGSCRMTKSYSESGLMGEPQPQGPPSWTDDCLSSQEEEHEAEKKEGDLEAMHAEAEVDSLRNGEEEEEEEEEDDLEEEEEEEEEEEEEEDDDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQSQDLPPHMQPPSASFPVHPYAYQSPGLPSPPYGTMDSSHLFHVKAPHSYGAALEPFFESALAECASPSFDGPLSPPLSVNGNFSFKHEPSGEFEKNYAFTMHYPAAAALAGTPGHGSLFSCSASRCEIPIDNLLPYESHAHHERVMSAQLNAIFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I062</accession>
    <name>A0A670I062_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">D-aspartate oxidase</fullName>
            <ecNumber evidence="10">1.4.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DDO</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Selectively catalyzes the oxidative deamination of acidic amino acids. Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors. Protects the organism from the toxicity of D-amino acids. May also function in the intestine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29990"/>
            <dbReference type="EC" id="1.4.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:12513"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-glutamate + O2 + H2O = 2-oxoglutarate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:10028"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:10029"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.1" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028578998.1">
        <property type="nucleotide sequence ID" value="XM_028723165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I062"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005126.1">
        <property type="protein sequence ID" value="ENSPMRP00000004807.1"/>
        <property type="gene ID" value="ENSPMRG00000003308.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000005130.1">
        <property type="protein sequence ID" value="ENSPMRP00000004811.1"/>
        <property type="gene ID" value="ENSPMRG00000003308.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594037"/>
    <dbReference type="KEGG" id="pmua:114594037"/>
    <dbReference type="CTD" id="8528"/>
    <dbReference type="GeneTree" id="ENSGT00390000018635"/>
    <dbReference type="OMA" id="DLWELQP"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008445">
        <property type="term" value="F:D-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0U4</accession>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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</entry>
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    <accession>A0A670I1L1</accession>
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        <name evidence="3" type="primary">ZNF318</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="282" mass="29921" checksum="99DE7E0ED1F325D6" modified="2020-06-17" version="1">GVRAPPPRDTGRDPGVRAPPPQDTGRDPDVRAPPPQDTGRNPGVRAPPPRDTGRDPDVRAPPPQDTGRDPGVQGPRCPGTPSSGHWKGPRRPGTPSSGHWKGPRRPGTPSSGHWKGPRRPGTPSSGHWKGPRRPGTPSSGHWKGPRRPGVRAPPPQDTGRDPGVRAPPPQDTGRDPGVRAPPPQDTGRDPGVRAPPPRDTGRDPGVRVPPPQDTGRDPGVRGSLPLPRLEGTQASGHPLLRILQGTQASGCHLLRTLEGTQARVEPRNKRKARPRLQGIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I7Q0</accession>
    <name>A0A670I7Q0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN-DOC-like zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I7Q0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008300.1">
        <property type="protein sequence ID" value="ENSPMRP00000007756.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="2">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="674" mass="76019" checksum="7A6817741B7780BB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9I9</accession>
    <name>A0A670I9I9_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I9I9"/>
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        <property type="protein sequence ID" value="ENSPMRP00000008515.1"/>
        <property type="gene ID" value="ENSPMRG00000005755.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163452"/>
    <dbReference type="OMA" id="HYNIVIC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="355" mass="41279" checksum="64D383A4565BCF23" modified="2020-06-17" version="1">MPKRTFITQEEAKLPGHKPMKDRLTLLFCANASGNLKIKPLLVYHSENPRTFKKHKVDKERLSVMWRSNSKAWVTRVLFVDWVNHAFGPAVKQYLLDNDLPLKALLLMDNAPAHPKGLEVDLLEEFSFISIMFLPPNTTALLQPMDQQLIANFKKLYTKELFRRCFEVTDCTTITLREFWKDHFDIVTCLKMITTAWNGISQRNLNCAWRSLWPDCVAPSDSDAPESTVVQDIVALGRTMGLEVTEEDISELVKEHDHELTTQELVELQAEAAQEQASLEEEEATEERLSSKELRDICLKWKDVQAFAQRHHPDKHVAHDLVNTFDTRVMSPFREVLKRRMKQQTMDRFFSKKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBZ4</accession>
    <name>A0A670IBZ4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcl-2-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Apoptosis regulator Bcl-X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BCL2L1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Secretory vesicle</location>
            <location evidence="4">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591409.1">
        <property type="nucleotide sequence ID" value="XM_028735576.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591410.1">
        <property type="nucleotide sequence ID" value="XM_028735577.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591411.1">
        <property type="nucleotide sequence ID" value="XM_028735578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IBZ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010060.1">
        <property type="protein sequence ID" value="ENSPMRP00000009430.1"/>
        <property type="gene ID" value="ENSPMRG00000006327.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599826"/>
    <dbReference type="KEGG" id="pmua:114599826"/>
    <dbReference type="CTD" id="598"/>
    <dbReference type="GeneTree" id="ENSGT01130000278332"/>
    <dbReference type="OMA" id="HAPTSHI"/>
    <dbReference type="OrthoDB" id="6021377at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097136">
        <property type="term" value="C:Bcl-2 family protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051434">
        <property type="term" value="F:BH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071839">
        <property type="term" value="P:apoptotic process in bone marrow cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071312">
        <property type="term" value="P:cellular response to alkaloid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071480">
        <property type="term" value="P:cellular response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097048">
        <property type="term" value="P:dendritic cell apoptotic process"/>
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        <property type="term" value="P:ectopic germ cell programmed cell death"/>
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        <property type="term" value="P:epithelial cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
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        <property type="term" value="P:fertilization"/>
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        <property type="term" value="P:negative regulation of protein localization to plasma membrane"/>
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        <property type="term" value="P:neuron apoptotic process"/>
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    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032946">
        <property type="term" value="P:positive regulation of mononuclear cell proliferation"/>
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        <property type="term" value="P:regulation of cytokinesis"/>
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        <property type="term" value="P:regulation of growth"/>
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        <property type="term" value="P:regulation of mitochondrial membrane permeability"/>
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        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
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        <property type="term" value="P:release of cytochrome c from mitochondria"/>
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        <property type="term" value="P:response to cycloheximide"/>
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        <property type="term" value="P:response to cytokine"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bcl-2-like protein 1"/>
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        <property type="entry name" value="Blc2-like"/>
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        <property type="entry name" value="Apop_reg_BclX"/>
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        <property type="entry name" value="Bcl-2_BH1-3"/>
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        <property type="entry name" value="Bcl-2_fam"/>
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        <property type="entry name" value="Bcl2-like"/>
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        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
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        <property type="entry name" value="Bcl2_BH3_motif_CS"/>
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        <property type="entry name" value="Bcl2_BH4"/>
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        <property type="entry name" value="bcl-2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BCL-2-LIKE PROTEIN 1"/>
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        <property type="entry name" value="APOPREGBCLX"/>
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        <property type="entry name" value="BCL2FAMILY"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BH4"/>
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    </dbReference>
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        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
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        <property type="entry name" value="BCL2_FAMILY"/>
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        <property type="entry name" value="BH1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50063">
        <property type="entry name" value="BH4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="10 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis regulator Bcl-2 family BH4" evidence="23">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="BH4" evidence="20">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004528"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00013629"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="227" mass="25776" checksum="B39ABE752B32EE20" modified="2020-06-17" version="1">MSRNNRALVVDFVSYKLSERGHSWDELEEDSENRTELRDEMDSVPNGSPSWHQSTSPVVNGATGHPSILSDLEDSPRLDVRQTLREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMRVLVGRIVSWMTTYLTDHLDPWIQENGGWERFVDLYGNDAAAKSRKGQERFNKWLWTGATVAGVVLLGSLLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IC51</accession>
    <name>A0A670IC51_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">C-terminal PDZ ligand of neuronal nitric oxide synthase protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Nitric oxide synthase 1 adaptor protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IC51"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009825.1">
        <property type="protein sequence ID" value="ENSPMRP00000009202.1"/>
        <property type="gene ID" value="ENSPMRG00000006181.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000046975"/>
    <dbReference type="OMA" id="EWPGARD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050998">
        <property type="term" value="F:nitric-oxide synthase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01270">
        <property type="entry name" value="PTB_CAPON-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000124">
        <property type="entry name" value="carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027851">
        <property type="entry name" value="DUF4628"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF76">
        <property type="entry name" value="CARBOXYL-TERMINAL PDZ LIGAND OF NEURONAL NITRIC OXIDE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15429">
        <property type="entry name" value="DUF4628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="35"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00067706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="668" mass="73255" checksum="7D3604FC0550ADDE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IC93</accession>
    <name>A0A670IC93_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Muscleblind like splicing regulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MBNL2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the muscleblind family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028584157.1">
        <property type="nucleotide sequence ID" value="XM_028728324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IC93"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010173.1">
        <property type="protein sequence ID" value="ENSPMRP00000009540.1"/>
        <property type="gene ID" value="ENSPMRG00000006387.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596583"/>
    <dbReference type="CTD" id="10150"/>
    <dbReference type="GeneTree" id="ENSGT00950000182897"/>
    <dbReference type="OMA" id="PTXNSEI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000004">
        <property type="entry name" value="Muscleblind like splicing regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000002">
        <property type="entry name" value="Muscleblind-like 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF4">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="378" mass="41425" checksum="740C883F11F6F269" modified="2020-06-17" version="1">MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKSRCTRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLQPMHSFPVGPTIGPNTALSFAPYLTPVTSGVGLVPTEIVPTQPVIVPGSPPVSVPGSTTTQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMTQSTAKAMKRPLEATVDLAFPPGVLHTLPKRQALEKSNGASAVFNPSFLHYQQALANAQLQQHAAFIPTDNPEIVNRNGMECQEASMKTAKHCYCTYYPVSSIELPQTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICA8</accession>
    <name>A0A670ICA8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ICA8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009877.1">
        <property type="protein sequence ID" value="ENSPMRP00000009252.1"/>
        <property type="gene ID" value="ENSPMRG00000006224.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="STYLECG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001808">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000990">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000862">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
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        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="566" mass="64701" checksum="7907A8DAD064A6EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDG8</accession>
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        <recommendedName>
            <fullName evidence="3">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MCMBP</name>
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    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCMBP family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028730080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IDG8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010366.1">
        <property type="protein sequence ID" value="ENSPMRP00000009723.1"/>
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    </dbReference>
    <dbReference type="GeneID" id="114597429"/>
    <dbReference type="KEGG" id="pmua:114597429"/>
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    <dbReference type="GeneTree" id="ENSGT00390000017265"/>
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    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:MCM complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
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    </dbReference>
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    </feature>
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        <location>
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            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="636" mass="72270" checksum="1D3C3E60A804E01C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDL3</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DNMT3B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IDL3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010667.1">
        <property type="protein sequence ID" value="ENSPMRP00000010010.1"/>
        <property type="gene ID" value="ENSPMRG00000006635.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156928"/>
    <dbReference type="OMA" id="CLEYSRI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051718">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000008">
        <property type="entry name" value="DNA (Cytosine-5)-methyltransferase 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.50">
        <property type="entry name" value="PWWP, helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0678">Repressor</keyword>
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    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="78"/>
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        <location>
            <begin position="254"/>
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        </location>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <sequence length="319" mass="36612" checksum="5E7CCF7FB9091211" modified="2020-06-17" version="1">MGYSHLKQFKTTYNLKNRVSPTIYIPSVKSQGKVATTPNFVSICLGIKTCLAFSIWLRRFHGMRSRGFSSQTSYLHLETFSFKPLLFSFLSMSLLNNSCDPNCVIVFEGPRLHLRSIRDIEMGEELTISYIETMMPTPDRQQHLKRQYCFECDCPMCHSQSKDADMLAGDEQAWKEAKEAINKMGAPKSQEEWEQALVTCQTLLKKNATRLPDTNIYQLKVLDFAMDACINLGLLEEALLYGHRTLEPYRVYYSGFHPLRAVQMMRVAKLQCSHDLFPQALETLKEAYDIMKVTHGTEHSLVHDLMMLKEDCEAGLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IF40</accession>
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        </recommendedName>
    </protein>
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        <name evidence="22" type="primary">PLCH2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bosakova Z."/>
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                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
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                <person name="Andersson L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="ENSPMRG00000007031.1"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16221">
        <property type="entry name" value="EFh_PI-PLCeta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphoinositide phospholipase C"/>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046971">
        <property type="entry name" value="PLC-eta2_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF166">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PIPLC_X_DOMAIN"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
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        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="20">
        <location>
            <begin position="592"/>
            <end position="705"/>
        </location>
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        <location>
            <begin position="706"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="494"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="889"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1009"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1053"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1117"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1203"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1254"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1326"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1405"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="957"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1123"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1274"/>
            <end position="1286"/>
        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00054490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010595.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1511" mass="169211" checksum="517E07911DFABF01" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IF96</accession>
    <name>A0A670IF96_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RPS6KA3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A670IF96"/>
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        <property type="protein sequence ID" value="ENSPMRP00000010354.1"/>
        <property type="gene ID" value="ENSPMRG00000005784.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to lipopolysaccharide"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="STKc_RSK2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05582">
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        <location>
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            <end position="327"/>
        </location>
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        <location>
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        <source>
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    </evidence>
    <sequence length="739" mass="83848" checksum="2DC8E184FF0726A8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IG10</accession>
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        </submittedName>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the ankyrin SOCS box (ASB) family.</text>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="PANTHER" id="PTHR24136:SF17">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 9"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="331" mass="35550" checksum="0BE09AA86C5882F2" modified="2020-06-17" version="1">MDVEGANANAGISQRSESQPHPTYLPNLLMGDFVSDWSPLHDASIHGRLLALKKLIHQGSSVNLVTADCVSPLHEACLGGHSACASVLLKHGANVNMATIDWNTPLFNACVSGSVDCLNLLLQHGASPHAVCDLASPIHEAAKRGHTKCVEALVSHGVNIDHNIKHLGTPLYVACESQQEDCVKKLLESGASANTGKGLNSPLHVAAQTSNANLVHLLIEFGADIGAVNAEGKKPADLVPPNNTLVQTLLQREVSARGEKDCKFFEVKAVFNSFPQIMVKDEIPLLSPFGAGESRMAHLTKINVIPEDCYFTFILKPHGNNWLLQIFPPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IH77</accession>
    <name>A0A670IH77_PODMU</name>
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        <submittedName>
            <fullName evidence="5">SH3 domain containing kinase binding protein 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">SH3KBP1</name>
    </gene>
    <organism evidence="5 6">
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            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    </organism>
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                <person name="Wallerman O."/>
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                <person name="Bellati A."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IH77"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011710.1">
        <property type="protein sequence ID" value="ENSPMRP00000010964.1"/>
        <property type="gene ID" value="ENSPMRG00000007049.1"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of B cell activation"/>
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        <property type="entry name" value="CIN85_SH3_2"/>
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        <property type="entry name" value="Endophilin_SH3RF"/>
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        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
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        <property type="entry name" value="SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1"/>
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        <property type="entry name" value="SH3_9"/>
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        <property type="entry name" value="P67PHOX"/>
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    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
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    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
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    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
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        <location>
            <begin position="286"/>
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    </feature>
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    </feature>
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            <begin position="202"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="573"/>
            <end position="596"/>
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    </feature>
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        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="692" mass="76593" checksum="0E551C4A596AAB5C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHD6</accession>
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            <fullName evidence="11">Transcription factor SOX-30</fullName>
        </recommendedName>
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        <name evidence="15" type="primary">SOX30</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="9">Acts both as a transcriptional activator and a repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4.</text>
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        <text evidence="10">Interacts with CTNNB1, competitively inhibiting CTNNB1-TCF7L2/TCF4 interaction.</text>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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        <property type="term" value="F:beta-catenin binding"/>
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        <property type="term" value="P:proacrosomal vesicle fusion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031960">
        <property type="term" value="P:response to corticosteroid"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-30"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="348"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
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            <end position="416"/>
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    </feature>
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        <location>
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            <end position="82"/>
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    </feature>
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            <end position="199"/>
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            <end position="587"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="686"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="737"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="537"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="686"/>
            <end position="701"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
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            <end position="751"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="765" mass="84110" checksum="E085C92B30119FF7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHM7</accession>
    <name>A0A670IHM7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
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    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IHM7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012408.1">
        <property type="protein sequence ID" value="ENSPMRP00000011615.1"/>
        <property type="gene ID" value="ENSPMRG00000007784.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000159769"/>
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        <property type="component" value="Chromosome 9"/>
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    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14086">
        <property type="entry name" value="STKc_CaMKII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000002">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000001">
        <property type="entry name" value="calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="14"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="512" mass="57841" checksum="0961F77F52F938BB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670III0</accession>
    <name>A0A670III0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670III0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012576.1">
        <property type="protein sequence ID" value="ENSPMRP00000011773.1"/>
        <property type="gene ID" value="ENSPMRG00000007878.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000214017"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="69" mass="7941" checksum="5A7F77FBABBD1612" modified="2020-06-17" version="1">MENLFNPLWSWLPRTIQLFQTRQNLIKGFRSFPGLPSHWLYGHADRLDFLIPPPCSHISCSGGGVLKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INF2</accession>
    <name>A0A670INF2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="18">DHOdehase</shortName>
            <ecNumber evidence="4 18">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="18">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 18"/>
    <dbReference type="AlphaFoldDB" id="A0A670INF2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014047.1">
        <property type="protein sequence ID" value="ENSPMRP00000013161.1"/>
        <property type="gene ID" value="ENSPMRG00000008805.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013574"/>
    <dbReference type="OMA" id="ERIKMGA"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DHO_dh"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 18" id="KW-0288">FMN</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
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    <keyword evidence="9 18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="37"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022792"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="337" mass="35730" checksum="D993724ACB11C32B" modified="2020-06-17" version="1">MPLLQRVVGPETAHRLAVRFVALGILPCSSQADSDALAVEVFGRQFRNPLGLAAGFDKHGEAVDGLYKMGFGFVEVGSVTPEPQEGNPRPRVFRLPEDQAIINRYGFNSHGHAVVEHRLRARQETQRQLSSAGMPLGINLGKNKASADAAADYVAGVRVLGPLADYLVVNVSSPNTPGLRALQGKAELRLLLAKVLAERDTLACKHKPAVLVKIAPDLTAQDKQDIASVVSELGVDGLVVTNTTVSRPSTLRAALRGEAGGLSGAPLRELSTQLVSEMYSLTQGRVPIIGVGGVSSGQDALDKIRAGASLVQMYTALTYRGPPVVGVVKQELEALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IPN5</accession>
    <name>A0A670IPN5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
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    <dbReference type="Ensembl" id="ENSPMRT00000014401.1">
        <property type="protein sequence ID" value="ENSPMRP00000013484.1"/>
        <property type="gene ID" value="ENSPMRG00000009030.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166555"/>
    <dbReference type="OMA" id="KDCHALC"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="479"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1256"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1287"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1347"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1370" mass="151264" checksum="0290F7CA76BE4373" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IS53</accession>
    <name>A0A670IS53_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
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        <text evidence="1">Belongs to the IFI44 family.</text>
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        <source>
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    </evidence>
    <sequence length="459" mass="51196" checksum="57B1B7A190DD96D0" modified="2020-06-17" version="1">MAQSRLTKTERKALLDILGCQHLSLLYKASLHTYNVNAFHNKCDSQGPTVVVGYNASGYIFGGFTEQSYASAGKYLFDNNAFMFRLKGKGQEPSILKFPVKNAVEAVLDNSAYGPTFGANTLVFLSESKNSVTTDANTNSYTLSAEDLHGNDQVLLECEVYRVEGLSSILEKPWREMTWTAEKREALMKEIRTYKPCLSAVPQCRVLLVGPVGAGKSSFFNSVNSTFRGYVSSQAAAGSDSTSLTKQYRTYHLKSGSGRTPLPIIFCDTMGLEVQPNAGLDIEDVRSILEGHIPDRYSFNPSCVMSPNMPNYIKSPSPKDRIHCVAFIIDGSKVEILPEKLEEKLKDIRRKANSFGVPQLVILTKVDQICPIVEEDISYVYKSMAVQKQMRLMEAKLGIPLSHIVPVKNYSSELELRNDVDILILMAVRQMLRLAEDYFDDFDDEPSVTRSTKDCYAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITS5</accession>
    <name>A0A670ITS5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat and coiled-coil-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00015683"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015588.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="734" mass="80871" checksum="4A5ABB08DE12E712" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUE2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized LOC114603195</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">LOC114603195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="529"/>
            <end position="618"/>
        </location>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="647" mass="72924" checksum="A902623AB1A30C49" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUF0</accession>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acylphosphate phosphohydrolase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <reaction evidence="6">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF21">
        <property type="entry name" value="ACYLPHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="80" mass="8872" checksum="3C64EFC8777CDF5F" modified="2025-10-08" version="2">MFPDIMGTQAEGKKLGVVGWVQNTDYGTVQGQIQGPTVKVRQLQEWLQKTGSPKSCIDRAEFCNEKKIACLGHSDFCIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IV85</accession>
    <name>A0A670IV85_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1-acylglycerol-3-phosphate O-acyltransferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AGPAT5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IV85"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016736.1">
        <property type="protein sequence ID" value="ENSPMRP00000015671.1"/>
        <property type="gene ID" value="ENSPMRG00000010468.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182836"/>
    <dbReference type="OMA" id="HRSTVDW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006639">
        <property type="term" value="P:acylglycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF73">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="8">
        <location>
            <begin position="168"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="446" mass="50878" checksum="1D78195D22B826D6" modified="2020-06-17" version="1">MREALRAPLRAPFPSRAREARARRGKARLLRAGGRSKPWPTPGSLRRRGGGAASSPAPFSSSVRGQEARGWRAVSPTLAGKMLLSLVLHTYSMRYVLPTALMMGTAPTYVLAWGAWRLLSTLLPARVYHEVDDRLYTLYQSMVLFFFENYTGVQIILYGDLPKNKENVVYISNHQCTVDWIIADMLAVRQNALGHVRYVLKDGLKWLPLYGWYFSQHGGVYVKRSAKFNERKMRNKLQAQIKAGTPMYLVIFPEGTRYNPELPKTIADSQSYADKAGLAVLKHVLTPRVKATHIAIDSMRTYLDAVYDITVAYEGTVDQKGQRKVAPSMTDFLCKECPRIHIYVDRIALKDIPEEQMYMRRWLHERFEIKDKLLIEFYDAKDSKRRNKFPGKCVRSKLSLKKTLPSLLFLSGLTVGMLLTESGRKLYVKTWLYGTLLGCLWVSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVE6</accession>
    <name>A0A670IVE6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Apolipoprotein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">APOB</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000016525.1">
        <property type="protein sequence ID" value="ENSPMRP00000015469.1"/>
        <property type="gene ID" value="ENSPMRG00000010317.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00590000083139"/>
    <dbReference type="OMA" id="FTCAYEN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034363">
        <property type="term" value="C:intermediate-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034362">
        <property type="term" value="C:low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034359">
        <property type="term" value="C:mature chylomicron"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034361">
        <property type="term" value="C:very-low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035473">
        <property type="term" value="F:lipase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050750">
        <property type="term" value="F:low-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048844">
        <property type="term" value="P:artery morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904646">
        <property type="term" value="P:cellular response to amyloid-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071402">
        <property type="term" value="P:cellular response to lipoprotein particle stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="APOLIPOPROTEIN B-100"/>
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        <property type="entry name" value="DUF1081"/>
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        <property type="entry name" value="VITELLOGENIN"/>
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    <keyword evidence="8" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="6" id="KW-0162">Chylomicron</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="11" id="KW-0427">LDL</keyword>
    <keyword evidence="10" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="18" id="KW-0850">VLDL</keyword>
    <feature type="domain" description="Vitellogenin" evidence="21">
        <location>
            <begin position="105"/>
            <end position="732"/>
        </location>
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        <location>
            <begin position="2185"/>
            <end position="2230"/>
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        <location>
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    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023313"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="4631" mass="520481" checksum="FDE22FC0590C8EA5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVR0</accession>
    <name>A0A670IVR0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Receptor-type tyrosine-protein phosphatase zeta</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">PTPRZ1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.</text>
    </comment>
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    <dbReference type="Ensembl" id="ENSPMRT00000016300.1">
        <property type="protein sequence ID" value="ENSPMRP00000015257.1"/>
        <property type="gene ID" value="ENSPMRG00000010174.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155529"/>
    <dbReference type="OMA" id="NISHGYI"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072534">
        <property type="term" value="C:perineuronal net"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:integrin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:learning or memory"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048709">
        <property type="term" value="P:oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031641">
        <property type="term" value="P:regulation of myelination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070445">
        <property type="term" value="P:regulation of oligodendrocyte progenitor proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="alpha_CARP_receptor_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="receptor-type tyrosine-protein phosphatase gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000004">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase zeta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000013">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase zeta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041887">
        <property type="entry name" value="Alpha_CARP_receptor-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
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    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
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        <property type="entry name" value="FN3_sf"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
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        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1074" mass="120425" checksum="C5AF9C476E46BE08" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IYB1</accession>
    <name>A0A670IYB1_PODMU</name>
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        <recommendedName>
            <fullName evidence="12">Amine oxidase</fullName>
            <ecNumber evidence="12">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="12">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11 12">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A670IYB1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018093.1">
        <property type="protein sequence ID" value="ENSPMRP00000016985.1"/>
        <property type="gene ID" value="ENSPMRG00000011269.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000003">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF4">
        <property type="entry name" value="RETINA-SPECIFIC COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10 12" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025577497" description="Amine oxidase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="15">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="16">
        <location>
            <begin position="157"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="14">
        <location>
            <begin position="298"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="10">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="11">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="583" mass="64991" checksum="9FB0C72903EAE281" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J0Q8</accession>
    <name>A0A670J0Q8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Platelet-activating factor receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114601634</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028594796.1">
        <property type="nucleotide sequence ID" value="XM_028738963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J0Q8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018316.1">
        <property type="protein sequence ID" value="ENSPMRP00000017199.1"/>
        <property type="gene ID" value="ENSPMRG00000011406.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601634"/>
    <dbReference type="KEGG" id="pmua:114601634"/>
    <dbReference type="GeneTree" id="ENSGT01150000286937"/>
    <dbReference type="OMA" id="YAMVGFF"/>
    <dbReference type="OrthoDB" id="5985406at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="7tmA_purinoceptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF91">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN LOC653160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="53"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017199.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="348" mass="38179" checksum="FCCAFB077761C453" modified="2020-06-17" version="1">MTKLPPFSSSGSIGMNNSTTSGLVVGQCRLNDPVQFILVPAVYCLVLCVGLPGNVAALLVFLQSGRVRKAIRIYLINLTLADIFFNLTLPFWIPYYLAEGHWELPEAFCRLAGATYYLATYSAMAFMTLISLNRYCTVAKLEMALNRPLGALVGCAVAWLLCFACAVPSLLTQQTYQVEAISMKCFEQHSGRRSYACAMVVLFAASFLVVLGAYMSIMRSLSASAGTCQGGHRRRARAMVLGMLLVFVVCVAPYHLSLVPWVADRMASSFCSPPSFLDNLHMLSVALLSLNSCIDPLIYCFSIKRFRTDLWTMVRKVVRCLPLPSAVPPPPPENRSPPNIRSSSLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1P7</accession>
    <name>A0A670J1P7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KIF5B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605716.1">
        <property type="nucleotide sequence ID" value="XM_028749883.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000019583.1">
        <property type="protein sequence ID" value="ENSPMRP00000018418.1"/>
        <property type="gene ID" value="ENSPMRG00000012114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607084"/>
    <dbReference type="KEGG" id="pmua:114607084"/>
    <dbReference type="CTD" id="3799"/>
    <dbReference type="GeneTree" id="ENSGT00940000154801"/>
    <dbReference type="OMA" id="FPMGTKQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
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        <property type="component" value="Chromosome 12"/>
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    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
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        <property type="term" value="C:postsynaptic cytosol"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:cellular response to type II interferon"/>
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        <property type="term" value="P:natural killer cell mediated cytotoxicity"/>
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        <property type="term" value="P:plus-end-directed vesicle transport along microtubule"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of potassium ion transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
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        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of membrane potential"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098987">
        <property type="term" value="P:regulation of modification of synapse structure, modulating synaptic transmission"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035617">
        <property type="term" value="P:stress granule disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000009">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF68">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="8"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="912"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="418"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="594"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="965" mass="110246" checksum="9FEFEBC54DBEA507" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3M0</accession>
    <name>A0A670J3M0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CCNY</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin Y subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605835.1">
        <property type="nucleotide sequence ID" value="XM_028750002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J3M0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019293.1">
        <property type="protein sequence ID" value="ENSPMRP00000018134.1"/>
        <property type="gene ID" value="ENSPMRG00000011946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607131"/>
    <dbReference type="KEGG" id="pmua:114607131"/>
    <dbReference type="CTD" id="219771"/>
    <dbReference type="GeneTree" id="ENSGT00940000154453"/>
    <dbReference type="OMA" id="KNRAHER"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000308">
        <property type="term" value="C:cytoplasmic cyclin-dependent protein kinase holoenzyme complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyclin-Y isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="173"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="341" mass="39461" checksum="8F0CBB2293A5D586" modified="2020-06-17" version="1">MGNTTSCCVSSSPKLRRNAHSRLESYRPDTELSREDTGCNLQHISDRENIDDLNMEFNPSDHPRASTIFLSKSQTDVREKRKSLFINHHAPGQLRRKYSSCSTIFLDDSTVTQPNLKYTIKSVALAIYYHIRNRDTDGRMLLDIFDENLHPLTKSEVPPDYDKHDPEQKQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNELERQFLELLQFNINVPSSVYAKYYFDLRSLAEANNLSFPLEPLSRDRAYKLEAISRLSEDKYKDFRKSAKKRSVSSDNLTVVRWSPAIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4X9</accession>
    <name>A0A670J4X9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J4X9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020423.1">
        <property type="protein sequence ID" value="ENSPMRP00000019235.1"/>
        <property type="gene ID" value="ENSPMRG00000012570.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="87" mass="9577" checksum="EBC1A162065777D6" modified="2020-06-17" version="1">MAGTTLRWSWMELMDCRMSSRVLSSRLGRGSCPQLPVHMARQPCFCHLLCHSLFGSPCSPTPASRSRKINVAPRPLGSPHAAPLFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5J1</accession>
    <name>A0A670J5J1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Interleukin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IL1B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the IL-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J5J1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020023.1">
        <property type="protein sequence ID" value="ENSPMRP00000018849.1"/>
        <property type="gene ID" value="ENSPMRG00000012332.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182943"/>
    <dbReference type="OMA" id="NDASFPC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005149">
        <property type="term" value="F:interleukin-1 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001660">
        <property type="term" value="P:fever generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23296">
        <property type="entry name" value="beta-trefoil_IL1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020877">
        <property type="entry name" value="IL-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000975">
        <property type="entry name" value="IL-1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10078:SF30">
        <property type="entry name" value="INTERLEUKIN-1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10078">
        <property type="entry name" value="INTERLEUKIN-1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00340">
        <property type="entry name" value="IL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00264">
        <property type="entry name" value="INTERLEUKIN1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01359">
        <property type="entry name" value="INTRLEUKIN1B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00125">
        <property type="entry name" value="IL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00253">
        <property type="entry name" value="INTERLEUKIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0497">Mitogen</keyword>
    <keyword evidence="8" id="KW-0666">Pyrogen</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="266" mass="28919" checksum="7C7E3813B6B89C8B" modified="2020-06-17" version="1">MWAGAEEGGGGRAAPGVTTEGGDKMLGGTHHVACSAPKPHVSPGSDTVAWVPVGSKWSACRLPLSYRVAEWEEAGRLLRGPTERPALILTQSVFSSSEPVDFDTCECTYATDPIYHLSRSISCNIRDVNQKSLVLNGTTQLVALELQQADISKEARVKMYVYRPKIGEGIAKIPIALKIKGKELYLSCVQSGDQPALQLEEASIEGDLDKSDKGRFLFYRVAVGDYTRFESAAFPQWYICTSAQVNKAVSVTNRIGEVSIVDYIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J6C6</accession>
    <name>A0A670J6C6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin heavy chain 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MYH11</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028561228.1">
        <property type="nucleotide sequence ID" value="XM_028705395.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000020960.1">
        <property type="protein sequence ID" value="ENSPMRP00000019730.1"/>
        <property type="gene ID" value="ENSPMRG00000012884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114583987"/>
    <dbReference type="KEGG" id="pmua:114583987"/>
    <dbReference type="CTD" id="4629"/>
    <dbReference type="GeneTree" id="ENSGT00940000155421"/>
    <dbReference type="OMA" id="QARITNM"/>
    <dbReference type="OrthoDB" id="10254995at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055013">
        <property type="term" value="P:cardiac muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048251">
        <property type="term" value="P:elastic fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000003">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000008">
        <property type="entry name" value="Myosin heavy chain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000007">
        <property type="entry name" value="Myosin heavy chain, non-muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.270.10:FF:000001">
        <property type="entry name" value="Myosin heavy chain, non-muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000017">
        <property type="entry name" value="myosin-10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000009">
        <property type="entry name" value="myosin-11 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF23">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="85"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="10">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1474"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1704"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1836"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1474"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1705"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1734"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1748"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1770"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1796"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1866"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1984" mass="228844" checksum="99403C5803BE85B9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J7G8</accession>
    <name>A0A670J7G8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">PR domain zinc finger protein 2</fullName>
            <ecNumber evidence="2">2.1.1.355</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">PR domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Retinoblastoma protein-interacting zinc finger protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Zinc finger protein RIZ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">PRDM2</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.355"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Binds to the retinoblastoma protein (RB). Interacts with GATA3.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.355" evidence="2"/>
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        <property type="nucleotide sequence ID" value="XM_028740583.1"/>
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    <dbReference type="Ensembl" id="ENSPMRT00000020798.1">
        <property type="protein sequence ID" value="ENSPMRP00000019579.1"/>
        <property type="gene ID" value="ENSPMRG00000012778.1"/>
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    <dbReference type="CTD" id="7799"/>
    <dbReference type="GeneTree" id="ENSGT00940000159410"/>
    <dbReference type="OMA" id="MASRCPS"/>
    <dbReference type="OrthoDB" id="6414306at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0140949">
        <property type="term" value="F:histone H3K9 trimethyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:methylation"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PR-SET_PRDM2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PR domain zinc finger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PR domain zinc finger protein 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PR/SET domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRDM2"/>
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    <dbReference type="InterPro" id="IPR044414">
        <property type="entry name" value="PRDM2_PR-SET"/>
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    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="Zinc_finger"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
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        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="11">Synaptoporin</fullName>
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        <name evidence="11" type="primary">SYNPR</name>
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        <name type="scientific">Podarcis muralis</name>
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    <sequence length="771" mass="85877" checksum="ED8781C37B019BC6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAI3</accession>
    <name>A0A670JAI3_PODMU</name>
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        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114603001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPMRP00000020679.1"/>
        <property type="gene ID" value="ENSPMRG00000013438.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00390000013448"/>
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        <property type="component" value="Chromosome 8"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sphinganine metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DES1/DES2"/>
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        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
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        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE_C4-MONOOXYGENASE DES2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="68"/>
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        </location>
    </feature>
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            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="322" mass="37641" checksum="1A5929B5B03A8828" modified="2020-06-17" version="1">MANTGSRDDFEWVYTDQPHTSRRKEILAKYPEIKKLMGPDPNMKWVVTLMVLTQLLACYLVKGLPWKWVFFWAYAFGGCINHSLALAIHDISHNVPFGNNKAKWNRFFGMFANLPIGVPYATSFKKYHVDHHRFLAVEGLDVDVPSELEGHFFNTPLRKFLWVFLQPLLYVLRPLFINPKPISKMEVINVAVQMCYDLLIYSLWGFKPVVYMVAGTLLAMGLHPFSGHFIAEHYMYAKGYDTVSYYGPLNWFTFNVGYHMEHHDFPSIPGSRLPLVRKIAPEYYDHLPYHNSWILVLWDFVFKRELGPFSRVKRTHKGDKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBN3</accession>
    <name>A0A670JBN3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SELENOO</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JBN3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021882.1">
        <property type="protein sequence ID" value="ENSPMRP00000020602.1"/>
        <property type="gene ID" value="ENSPMRG00000013389.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005508"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153:SF15">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153">
        <property type="entry name" value="SELENOPROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="713" mass="80992" checksum="BE3C45562FA44E30" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC15</accession>
    <name>A0A670JC15_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114602522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028596691.1">
        <property type="nucleotide sequence ID" value="XM_028740858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JC15"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023178.1">
        <property type="protein sequence ID" value="ENSPMRP00000021836.1"/>
        <property type="gene ID" value="ENSPMRG00000014180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602522"/>
    <dbReference type="KEGG" id="pmua:114602522"/>
    <dbReference type="GeneTree" id="ENSGT00940000165046"/>
    <dbReference type="OMA" id="GIGLEYC"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="253" mass="27175" checksum="AE6ABC922E520F84" modified="2020-06-17" version="1">MDQALCRSVLITGANRGIGLGLVEGFLAASPCPEVVIATCRCPESAQELQKLCKQYSNIRVLPLDVVSENSIKETVKKVEDIVGEKGLNCLINNAGINVLGSLEDVTTEAMLRTFETNTVAQLMLSKAFLPLLKTAAKQSSTMGCHRAAIVNMSSISASIGLAKSNDIYHAVYPYRISKAALNMLTKCLATDLKLEGILCIALHPGWIQTDMGGTKAPLKVQDAVPSIISLLAQLSEKDNGAFLDWEGKTLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JCE5</accession>
    <name>A0A670JCE5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription activation suppressor family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TASOR2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028603625.1">
        <property type="nucleotide sequence ID" value="XM_028747792.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000023385.1">
        <property type="protein sequence ID" value="ENSPMRP00000022016.1"/>
        <property type="gene ID" value="ENSPMRG00000014319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606032"/>
    <dbReference type="CTD" id="54906"/>
    <dbReference type="GeneTree" id="ENSGT00530000063735"/>
    <dbReference type="OMA" id="VPCYIQI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056242">
        <property type="entry name" value="PIN_TASOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046432">
        <property type="entry name" value="TASOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056243">
        <property type="entry name" value="TASOR_ab_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207:SF10">
        <property type="entry name" value="PROTEIN TASOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24630">
        <property type="entry name" value="PIN_TASOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23314">
        <property type="entry name" value="TASOR_alpha-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TASOR alpha/beta" evidence="2">
        <location>
            <begin position="2151"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="domain" description="TASOR PIN" evidence="3">
        <location>
            <begin position="2250"/>
            <end position="2389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <begin position="1215"/>
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            <begin position="1980"/>
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        <location>
            <begin position="2095"/>
            <end position="2121"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
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        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
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        <location>
            <begin position="577"/>
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        </location>
    </feature>
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        <location>
            <begin position="857"/>
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        <location>
            <begin position="870"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1365"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1668"/>
            <end position="1678"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022016.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="2400" mass="264264" checksum="895E114E90DB911A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JD13</accession>
    <name>A0A670JD13_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
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    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670JD13"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR24346:SF80">
        <property type="entry name" value="HORMONALLY UP-REGULATED NEU TUMOR-ASSOCIATED KINASE"/>
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    </dbReference>
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        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="15270" checksum="693AF6BD14CA17C9" modified="2020-06-17" version="1">MCSTTKLRVFTALDFVLYGQEPFKLISVQSSTVAVKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPYIAQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEEHEARKYIRQLILAVEHLHRAGVVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JDQ8</accession>
    <name>A0A670JDQ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acidic mammalian chitinase</fullName>
            <ecNumber evidence="5">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with EGFR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670JDQ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022583.1">
        <property type="protein sequence ID" value="ENSPMRP00000021277.1"/>
        <property type="gene ID" value="ENSPMRG00000013818.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162989"/>
    <dbReference type="OMA" id="VWAHEAN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000001">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000081">
        <property type="entry name" value="Chitinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
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        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
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    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
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    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF248">
        <property type="entry name" value="CHITOTRIOSIDASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="15" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="23">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="23">
        <location>
            <begin position="344"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="22">
        <location>
            <begin position="749"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="800" mass="88125" checksum="06AE289E0E8C910A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JER7</accession>
    <name>A0A670JER7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="4 15">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MAP3K13</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="4 15"/>
    <dbReference type="RefSeq" id="XP_028586658.1">
        <property type="nucleotide sequence ID" value="XM_028730825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JER7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023467.1">
        <property type="protein sequence ID" value="ENSPMRP00000022094.1"/>
        <property type="gene ID" value="ENSPMRG00000014374.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597691"/>
    <dbReference type="CTD" id="9175"/>
    <dbReference type="GeneTree" id="ENSGT00940000158216"/>
    <dbReference type="OMA" id="CAEDRGY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106137">
        <property type="term" value="F:IkappaB kinase complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045773">
        <property type="term" value="P:positive regulation of axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905492">
        <property type="term" value="P:positive regulation of branching morphogenesis of a nerve"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014042">
        <property type="term" value="P:positive regulation of neuron maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150012">
        <property type="term" value="P:positive regulation of neuron projection arborization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14059">
        <property type="entry name" value="STKc_MAP3K12_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000087">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000095">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017419">
        <property type="entry name" value="MAP3K12_MAP3K13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF14">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038165">
        <property type="entry name" value="MAPKKK12_MAPKKK13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="177"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="567"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="750"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
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    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-malate + a quinone = enol-oxaloacetate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:79827"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:17479"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:79828"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-malate + a quinone = enol-oxaloacetate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:79831"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:17479"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:79832"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a ubiquinone + succinate = a ubiquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:13713"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 22">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Mitochondrion inner membrane</location>
            <topology evidence="1 22">Peripheral membrane protein</topology>
            <orientation evidence="1 22">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family. FIG1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="22"/>
    <dbReference type="AlphaFoldDB" id="A0A670JK16"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026848.1">
        <property type="protein sequence ID" value="ENSPMRP00000025293.1"/>
        <property type="gene ID" value="ENSPMRG00000016367.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144277"/>
    <dbReference type="OMA" id="PTGIWRM"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 22" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 20 22" id="KW-0274">FAD</keyword>
    <keyword evidence="7 20 22" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 22" id="KW-0813">Transport</keyword>
    <keyword evidence="6 22" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="23">
        <location>
            <begin position="61"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="24">
        <location>
            <begin position="510"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="454"/>
            <end position="455"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="21">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="669" mass="73209" checksum="24A9A2B867AD7C91" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKI9</accession>
    <name>A0A670JKI9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasmic polyadenylation element binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CPEB2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPEB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JKI9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026411.1">
        <property type="protein sequence ID" value="ENSPMRP00000024891.1"/>
        <property type="gene ID" value="ENSPMRG00000016085.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12724">
        <property type="entry name" value="RRM1_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12726">
        <property type="entry name" value="RRM2_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000008">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000001">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF8">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="483"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="632" mass="68481" checksum="D04CF5C7301C5CD6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JL47</accession>
    <name>A0A670JL47_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JL47"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026184.1">
        <property type="protein sequence ID" value="ENSPMRP00000024675.1"/>
        <property type="gene ID" value="ENSPMRG00000015945.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158146"/>
    <dbReference type="OMA" id="VWAPRGE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000004">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF67">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="9">
        <location>
            <begin position="162"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="10">
        <location>
            <begin position="324"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="488" mass="54388" checksum="048464904F8242F0" modified="2020-06-17" version="1">MSLTKLREAVEDRSAWRALVQGVTKSRTRLNNNNHFPPDIPGTDKTFRSSLAAACCHWHDLPWQRSLQTKVPPPKLSPHPTLTDAPFPPPACCLPRRGREREREREREAGRRKHGEGTSRKKRACQEVCGLSRPGLLAGSAPSGVSSRSLPSHLMFRSRRASLAQRLWRHRCVTPGPDDSHGALKPAALALFKKLKEKELELLLWAVESRGAGESGCVWVESRGSKPGLPASLLLCRLFRWPDLRHPHELKRLSFCKSTGGEGSVHCCNPHHLSRLAVPETPLPPYGKISPFATPLKCANTLNNNRRIWQDTSLSQRSLRDGHWCKLAYWEHRLRVGRLFSVHDDHVNIFADLPAGSGFCLGQLGSRNRSQAVQRARAKIGQGLLLSREGSGVWAYNRSDHPVFVCSPTLGPPGGSGPAVHKLLPGYSLKVFDYDRAGNLACWQGHHDGPYDAHSVRISFGKGWGQCYSRRFITSCPCWLEVLLSIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLS7</accession>
    <name>A0A670JLS7_PODMU</name>
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        <submittedName>
            <fullName evidence="3">Transmembrane protein 252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JLS7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025389.1">
        <property type="protein sequence ID" value="ENSPMRP00000023927.1"/>
        <property type="gene ID" value="ENSPMRG00000015490.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031363">
        <property type="entry name" value="TMEM252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35682">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35682:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 252"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF15664">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025676928" evidence="2">
        <location>
            <begin position="25"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="196" mass="22308" checksum="AC56A6EAC5749DC1" modified="2020-06-17" version="1">MSKNIFSFLRLLVLLLGFAFICLGAYCFSTSASACKCNSLPIAYFLLPLGFFFLISGIFWSTYHEASKHKGLFHMQLLPVNMHGVLPTCVVFCLGCFLCRPDFYPPSYEDSTDPEKQTFALPICPQEQVKDMYNIPPPLYTESSLEFLEEASPQEQRPPTYEVSWLGLMHRMQSVVEVKRGKHCSMQWGEDSNCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNU5</accession>
    <name>A0A670JNU5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydroxysteroid dehydrogenase-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HSDL2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JNU5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027668.1">
        <property type="protein sequence ID" value="ENSPMRP00000026071.1"/>
        <property type="gene ID" value="ENSPMRG00000016872.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156729"/>
    <dbReference type="OMA" id="WWSSVAN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydroxysteroid dehydrogenase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSDL2"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006133">
        <property type="entry name" value="PRK08278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF3">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="10">
        <location>
            <begin position="345"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040243"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="457" mass="48946" checksum="055485FA7E3DDC2D" modified="2020-06-17" version="1">MLPNTGRLAGCTLFITGASRGIGKAIALKAAKDGANIVIAAKTGVPHRTLPGTIYTAAEEIEAAGGKALACIVNVREEEQIVDAVDQAVQKFGGIDVLVNNASAISLTGTLDTPTKKVDLMMSANTRGTYLTSKICLPYLKKSKIGHILNISPPINLNPIWFKNHCAYTISKYGMSMCVLGMAEEFRGEVAVNALWPQTAIYTSAMDMLGGAGVEKQCRKTDILADAAYCILTKPKTFTGNFVIDETLLREEGIQNFDVYAVAPGHPLLPDFFLDVDPETLAMKMEAQGATPTFREGKKQDLPKHEGPDKTKPEGPDRGKLHVHFAAEKSGGPVAETFKIIKAAISDEVVKSTQGIYRFELSGEGGGAWYIDLKNKGGSVGSGEPPGKVDVVMSMSSTDFVKMFSGKLKPTLAFMSGKLAIKGDMALAIKLERLMGQRGARIHHELPCSLRMAIAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPM0</accession>
    <name>A0A670JPM0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">E1A binding protein p400</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EP400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000027942.1">
        <property type="protein sequence ID" value="ENSPMRP00000026341.1"/>
        <property type="gene ID" value="ENSPMRG00000016768.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154764"/>
    <dbReference type="OMA" id="YGEDCRG"/>
    <dbReference type="Proteomes" id="UP000472272">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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            <taxon>Episquamata</taxon>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
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        </source>
    </evidence>
    <sequence length="157" mass="17335" checksum="139E53FA8CB78BBD" modified="2020-06-17" version="1">MAESPKPGDQIEIYRLGYQHWAIYVGDGYVVHLTAADEGVESFLCSCPTPYTKMGVVKKEKLSEVAGKNKWKVNNKKDRKYKARPVSEIISTANGYVGGKIMYDVVVHNCEHFAAILRYGQRDSRQVEVGFWVTFAATVAVAMGASLVAAAIIGKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTS6</accession>
    <name>A0A670JTS6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">INPP5B</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670JTS6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030283.1">
        <property type="protein sequence ID" value="ENSPMRP00000028548.1"/>
        <property type="gene ID" value="ENSPMRG00000018016.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156762"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052658">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070613">
        <property type="term" value="P:regulation of protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09093">
        <property type="entry name" value="INPP5c_INPP5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04380">
        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000132">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase OCRL-1 isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000012">
        <property type="entry name" value="Putative inositol polyphosphate 5-phosphatase OCRL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000004">
        <property type="entry name" value="Type II inositol 1,4,5-trisphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037793">
        <property type="entry name" value="OCRL1/INPP5B_INPP5c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025398906" description="phosphoinositide 5-phosphatase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="11">
        <location>
            <begin position="726"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="911" mass="102559" checksum="9D534AD84D24BD87" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUK0</accession>
    <name>A0A670JUK0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SFI1 centrin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SFI1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028565886.1">
        <property type="nucleotide sequence ID" value="XM_028710053.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565887.1">
        <property type="nucleotide sequence ID" value="XM_028710054.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565888.1">
        <property type="nucleotide sequence ID" value="XM_028710055.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565889.1">
        <property type="nucleotide sequence ID" value="XM_028710056.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565891.1">
        <property type="nucleotide sequence ID" value="XM_028710058.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565892.1">
        <property type="nucleotide sequence ID" value="XM_028710059.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565893.1">
        <property type="nucleotide sequence ID" value="XM_028710060.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565894.1">
        <property type="nucleotide sequence ID" value="XM_028710061.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565895.1">
        <property type="nucleotide sequence ID" value="XM_028710062.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565900.1">
        <property type="nucleotide sequence ID" value="XM_028710067.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565901.1">
        <property type="nucleotide sequence ID" value="XM_028710068.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565903.1">
        <property type="nucleotide sequence ID" value="XM_028710070.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565904.1">
        <property type="nucleotide sequence ID" value="XM_028710071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JUK0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028152.1">
        <property type="protein sequence ID" value="ENSPMRP00000026537.1"/>
        <property type="gene ID" value="ENSPMRG00000017158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586505"/>
    <dbReference type="KEGG" id="pmua:114586505"/>
    <dbReference type="CTD" id="9814"/>
    <dbReference type="GeneTree" id="ENSGT00940000154110"/>
    <dbReference type="OMA" id="RCENNEE"/>
    <dbReference type="OrthoDB" id="195843at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF4">
        <property type="entry name" value="PROTEIN SFI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1130"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1260" mass="149922" checksum="14E4661503300362" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVP5</accession>
    <name>A0A670JVP5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PCAF-associated factor 65-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TAF6L</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566525.1">
        <property type="nucleotide sequence ID" value="XM_028710692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JVP5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028483.1">
        <property type="protein sequence ID" value="ENSPMRP00000026847.1"/>
        <property type="gene ID" value="ENSPMRG00000017344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586854"/>
    <dbReference type="KEGG" id="pmua:114586854"/>
    <dbReference type="CTD" id="10629"/>
    <dbReference type="GeneTree" id="ENSGT00640000091486"/>
    <dbReference type="OMA" id="QKCRFSP"/>
    <dbReference type="OrthoDB" id="6621890at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22932">
        <property type="entry name" value="HFD_TAF6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000040">
        <property type="entry name" value="TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000002">
        <property type="entry name" value="TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF22">
        <property type="entry name" value="TAF6-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="13">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="473"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="625" mass="68958" checksum="1D2E06B2BB600520" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVW9</accession>
    <name>A0A670JVW9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin NUP42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nucleoporin-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NUP42</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JVW9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028559.1">
        <property type="protein sequence ID" value="ENSPMRP00000026917.1"/>
        <property type="gene ID" value="ENSPMRG00000017384.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000118"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="429" mass="48022" checksum="FD2A21F6635B9356" modified="2020-06-17" version="1">MTYSVCHYFLQGHCRFGDNCWNEHPRQHAGRANAGKNGRMSRSASPPAASLRSGRRVAWSGHNQRYSNPVQTSSFSKSTSWHNRDSGFSQNRYAALNSTENVGNSGIVDEEDKLLEIIMKDMESWESSGQWMFSTYSPMKEKPNISGFPDFLPEELRLEYYNSRANNNVQNYINSVQQLASQWRSRLLELKNINASTKAALVSVIEKMKRSSFKVSNLFCKVCKSFSHVSEIIVMVMYRIFRPIGRTFPPPKMKGKCVCILWGECRLSLKPGEPHRQPHKLGGQRGGGTPPSRCLPTWFGGWRRGDACFSPPPAPQAWGTAGRRSAPSHCLPTWFGGWRRASPSPSPACSQSGLRAALRKLWEPSATSRWLPRLAESCLFGGLGWGKLGLLPPQPHAWGGGDKKILYPPPKKNLDASYGPVRPIGQKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXU8</accession>
    <name>A0A670JXU8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">IDH3A</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:23633"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JXU8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031066.1">
        <property type="protein sequence ID" value="ENSPMRP00000029291.1"/>
        <property type="gene ID" value="ENSPMRG00000018931.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182989"/>
    <dbReference type="OMA" id="CLKLITQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="171"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="504" mass="54114" checksum="7BD7DA29C9C55CF2" modified="2020-06-17" version="1">MQCTKYMRGDQVLQVRGPRQPPLPTPGATTPKFPPGLGSGSSAAPPRLPFALPALSAAHWGPPSPAKSGAPVEVACMHAGRRVAIALHCTPCNACTHALPCTPAKGSPRGPMRPLRRGCSIAKIKNPRRSPTWGAASASAMAWWAPKVFRLLEAFKGQKQVTRSFGSSVQTVTLIPGDGIGPEISAAVVEIFAAAKAPVQFEERNVTAIQGPGGKWTIPQDAKESMDKNKIGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVDIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEDASKRIADFAFEYARNNQRSKVTAVHKANIMRMSDGLFLKKCREAAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMGMQEYATKIEDACFDTIKDGKVLTKDLGGNSKCSEFTAEICRRVRAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JY66</accession>
    <name>A0A670JY66_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JY66"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032096.1">
        <property type="protein sequence ID" value="ENSPMRP00000030268.1"/>
        <property type="gene ID" value="ENSPMRG00000019569.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13517" checksum="A5C87B55C8DE789E" modified="2020-06-17" version="1">IGGGAEGRWIPHLVSLYFADDNWALQRALYKDVMVEVREMVWVPQWLRVPPFSSAKGGHLSCYWFLLMFWFVCCMLSELLPDPSSQRITLASVHFIKVFIELQFPFSSCRVQLYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZF8</accession>
    <name>A0A670JZF8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidoglycan recognition protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114586949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566655.1">
        <property type="nucleotide sequence ID" value="XM_028710822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JZF8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029824.1">
        <property type="protein sequence ID" value="ENSPMRP00000028112.1"/>
        <property type="gene ID" value="ENSPMRG00000018152.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586949"/>
    <dbReference type="KEGG" id="pmua:114586949"/>
    <dbReference type="GeneTree" id="ENSGT00940000161006"/>
    <dbReference type="OMA" id="RFVVIHH"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Amidase/PGRP_sf"/>
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        <property type="entry name" value="Amidase_domain"/>
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    </dbReference>
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        <property type="entry name" value="PGRP_domain_met/bac"/>
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    </dbReference>
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        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN 3"/>
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            <begin position="36"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <sequence length="187" mass="20855" checksum="C740897C6B0478AD" modified="2020-06-17" version="1">MMASQEIILLFLCALSQASGCFKLITPSKWGAKPANCSEPLKDLPPEYVIIIHTAQNPCKTRAECSREVRNAQDYHLGLKGWCDVAYNFLIGEDGLVYEGRGWRNVGSHTYGYNDLSLGIAFIGTFVERSPNQAAWKALKCLLDFSVKVGYLSPDYLVIAHSDVSNLVSPGEPIRSEISKWPNYRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K071</accession>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="TCR_beta_variable"/>
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        <property type="entry name" value="T CELL RECEPTOR BETA VARIABLE 30"/>
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            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="151" mass="16376" checksum="6AB65DD5D2095370" modified="2020-06-17" version="1">MATLWPICALLWLAIGISCDGSPTIVQTPQSVIQRPDSKVSLNCNINGGSNPNIYWYRQILKGQIQLLAYSVAVGSSSAEGPPHIQGSRPEDTKFFLSIKNLMANDTGIYYCAWSPHTVQSECNTSTKTLLLACGSVCSHTAGKWGKRCIL</sequence>
</entry>
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    <accession>A0A670K0Z8</accession>
    <name>A0A670K0Z8_PODMU</name>
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        <submittedName>
            <fullName evidence="3">Heparin binding growth factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HDGF</name>
    </gene>
    <organism evidence="3 4">
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K0Z8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033083.1">
        <property type="protein sequence ID" value="ENSPMRP00000031188.1"/>
        <property type="gene ID" value="ENSPMRG00000020210.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157485"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd20148">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="hepatoma-derived growth factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047363">
        <property type="entry name" value="PWWP_HDGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF41">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="252"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="500"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="500" mass="53251" checksum="AA9FFC0351EFB506" modified="2020-06-17" version="1">MAAGAGLLCQPPEAPRPREAEEASALGSPCNAAAFSAGRAVHVRDPLRISAPPLIKSEQTPPPRALCRPPSPSSALPSWGHLGSAGEAPLQIPSPPASENKEPRLKRKAFPAAGVSSRAPRARRPPGSPISRAASGSWAGASSASWRPGAGKGSGLVGGGGAGPPSPASPPLFKHKQAPPGSPGAPPPAKLLRGGGGGGGPESSARPEEQPEPQQQPQEEARRSRSPRRRQAARRPSRRAMSRSNRQREYKCGDLVFAKMKGYPHWPARIDEMPESAVKSASNKYQVFFFGTHETAFLGPKDLFPYEECKGKFGKANKRKGFSEGLWEIENNPTVKASGYQPTQKKAPTEDAGAEREPEAGQKKETPEGSSDEEGNLVIDEQSKEKNEKAGSKRKAEGPLLEDSSPKRTKESEDQEGAGGEKPKGCEGDAPKETEKPKKPQPSSLLPDGGKEKEENSSRAADAPAGGEGKEEASEEEDEEEEEDEEEEEEEEASRDHKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K1C4</accession>
    <name>A0A670K1C4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Astrocytic phosphoprotein PEA-15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">15 kDa phosphoprotein enriched in astrocytes</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PEA15</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028564989.1">
        <property type="nucleotide sequence ID" value="XM_028709156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K1C4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033223.1">
        <property type="protein sequence ID" value="ENSPMRP00000031323.1"/>
        <property type="gene ID" value="ENSPMRG00000020306.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586143"/>
    <dbReference type="KEGG" id="pmua:114586143"/>
    <dbReference type="CTD" id="8682"/>
    <dbReference type="GeneTree" id="ENSGT00390000000230"/>
    <dbReference type="OMA" id="ATSKDWF"/>
    <dbReference type="OrthoDB" id="9931131at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046325">
        <property type="term" value="P:negative regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902043">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08338">
        <property type="entry name" value="DED_PEA15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029546">
        <property type="entry name" value="PEA15_DED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF1">
        <property type="entry name" value="ASTROCYTIC PHOSPHOPROTEIN PEA-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00031">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DED" evidence="9">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="15212" checksum="4B5229067531A447" modified="2020-06-17" version="1">MAEYSSLLEELAENITNEDLDQLKSACKEDIPSEKNEEITTSKDWFSFLEKHKKLDKDNLSYIEHIFEISRRPDLLTMVVEYRTQVLKISEEDEVDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2F9</accession>
    <name>A0A670K2F9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K2F9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030911.1">
        <property type="protein sequence ID" value="ENSPMRP00000029142.1"/>
        <property type="gene ID" value="ENSPMRG00000018837.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154179"/>
    <dbReference type="OMA" id="YCQTWTT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025672786" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="118" mass="13066" checksum="77C5B0FF1A6D878F" modified="2020-06-17" version="1">MAWTLCFLALLSCFSGVISQNTLIQPPSQSVSPGETIKLSCTASSSRSYIYWYQQRPGQAPRYVHRNGGSRGEGIPDRFTASLSGNMGYLIITNIQGEDEAVYYCAAWFSNELHCDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K488</accession>
    <name>A0A670K488_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heme-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K488"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032315.1">
        <property type="protein sequence ID" value="ENSPMRP00000030469.1"/>
        <property type="gene ID" value="ENSPMRG00000019720.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01000000214806"/>
    <dbReference type="OMA" id="AYEERTY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF22">
        <property type="entry name" value="HEME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="180" mass="20191" checksum="B2097F33158DE906" modified="2020-06-17" version="1">MHGLRLSRNLLSDFCVPKKLNNEEKEYEGGKFATIEHTGETFDAACLEAVAKLYKYFEGSNDQGAKMSVVDPVCITALPADDGSLQLKVKVSLQIPSQFQASPPSPADKSIRIEQRGKMAVFFMTFHGNAKGENYKNYAAQLRSAVGTEKADHKELYIFSSYDPQNKSFWNCHEVSLWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6P7</accession>
    <name>A0A670K6P7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorting nexin 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SNX31</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K6P7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034458.1">
        <property type="protein sequence ID" value="ENSPMRP00000032496.1"/>
        <property type="gene ID" value="ENSPMRG00000021056.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183212"/>
    <dbReference type="OMA" id="EQYLQNX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000297">
        <property type="entry name" value="Sorting nexin 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000230">
        <property type="entry name" value="Sorting nexin 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000008">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048763">
        <property type="entry name" value="SNX17-31_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040842">
        <property type="entry name" value="SNX17/31_FERM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF15">
        <property type="entry name" value="SORTING NEXIN-31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21273">
        <property type="entry name" value="SNX17-27-31_F1_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18116">
        <property type="entry name" value="SNX17_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="336" mass="39138" checksum="0596E314EEEE39B6" modified="2020-06-17" version="1">LKVHYFPKRILGAVLYSVYLEGFLFCKVRYSQLHHWNEQLRRIFGKGVPAFPPKFYLAMTKSMADERRAQLEQYLQNVSIDPSITNSDVFISFFRKLQQDTFKIQTQQSFLDVYLADGRYLRIDIQTSDTAERVLEVVSYKIELSRELIGYFSLFLIQDHNNGELSVLKKLAEFELPYVSLQSMKESPCKIGIRKWYMDPSLDKMLMNCRTSVNLLYIQVRGWDFSVSLAQFLELAQEVQHYGYIKLAPCSCDYPEAGCTAAIHVGNNEISCCIKLPSNQIKEVSFKINRVRCWQVTFLGSVTGQGLDQFLELRFEYNDSDTWRWIAFNTKQVCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6S6</accession>
    <name>A0A670K6S6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K6S6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033229.1">
        <property type="protein sequence ID" value="ENSPMRP00000031329.1"/>
        <property type="gene ID" value="ENSPMRG00000020307.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155469"/>
    <dbReference type="OMA" id="KWHENDV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060002">
        <property type="term" value="F:plus-end directed microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051724">
        <property type="entry name" value="Actin_motor_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049">
        <property type="entry name" value="AGAP003327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049:SF2">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 5" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="6">
        <location>
            <begin position="55"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="153" mass="17856" checksum="941587DF632C663F" modified="2020-06-17" version="1">MLSCVCVCVCVDRNGERKSRICFSRTAFSLFQVYTYKQRSITRQKVTAMQPTNSEGLEDMAALIDLHEGAIMYNLFQRYQQNKIYTYIGSIVASVNPYKTIPGLYDRATVEHYSRHHLGEISPHIFAVANECYRCLWKRHDNQCVLIRYRNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7V2</accession>
    <name>A0A670K7V2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Angiopoietin-1/2/4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K7V2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035713.1">
        <property type="protein sequence ID" value="ENSPMRP00000033663.1"/>
        <property type="gene ID" value="ENSPMRG00000021826.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160129"/>
    <dbReference type="OMA" id="RAFCSHA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057439">
        <property type="entry name" value="ANG-1/2/4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25443">
        <property type="entry name" value="ANG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Angiopoietin-1/2/4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="14741" checksum="1B24A7C7F1CC8534" modified="2020-06-17" version="1">METKHLMELEGIRTEKEELQQLVIRQSDTIEVLEKSLHAASGNTSLLQQQQLQLLESVQNLVQLVSQGKVPPKKEDRLFQDCAEIRQSGINLSGVYTLHINNLTEPKKVSETPRAYELRQGEGSLLNLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9H1</accession>
    <name>A0A670K9H1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BCL2 interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BNIP2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028562561.1">
        <property type="nucleotide sequence ID" value="XM_028706728.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028562562.1">
        <property type="nucleotide sequence ID" value="XM_028706729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K9H1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035480.1">
        <property type="protein sequence ID" value="ENSPMRP00000033446.1"/>
        <property type="gene ID" value="ENSPMRG00000021671.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584696"/>
    <dbReference type="CTD" id="663"/>
    <dbReference type="GeneTree" id="ENSGT00940000158531"/>
    <dbReference type="OMA" id="SWYRTKK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000001">
        <property type="entry name" value="BCL2/adenovirus E1B protein-interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022181">
        <property type="entry name" value="Bcl2-/adenovirus-E1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF12">
        <property type="entry name" value="BCL2_ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12496">
        <property type="entry name" value="BNIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="4">
        <location>
            <begin position="142"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="323" mass="37607" checksum="1D077D309B4CDE4F" modified="2020-06-17" version="1">MEGVELKEEWQDEDFPRPLPEDDHIDDMSDPAERGDQPEVNGNKVKKKLLAPNINLTLDCSEESILSDLDESGDIDLDDMDTPSENSNEFEWEDDLPKPKTTDVIQKGSLQEYAASDEKEEERRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIVYLNGATTRRKMPSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAITKPFISSKFSQKIRYVFTLAELAELVPMEYVGIPECIKQYEEEKFKKKPKRYMHILIRAVSNLANFALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9R2</accession>
    <name>A0A670K9R2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IF rod domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K9R2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033457.1">
        <property type="protein sequence ID" value="ENSPMRP00000031542.1"/>
        <property type="gene ID" value="ENSPMRG00000020435.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156146"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050405">
        <property type="entry name" value="Intermediate_filament"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652">
        <property type="entry name" value="GLIAL FIBRILLARY ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652:SF5">
        <property type="entry name" value="VIMENTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="171" mass="20020" checksum="9A3202F395EFE2ED" modified="2020-06-17" version="1">MLILTLYNCKTQFKKFKEEEEEYYLDALKGTNESLERQMREMEENFNLEAANYQDNITRLQEVIQNMKEEMACHRHKYQDLLNVKMALDIEIATYRKLLEGEESRITMPIPTFASLNLTCPVLRLGTASHLLLPNLWKDQTKIPHLLTPQQKSRLQPQGEVQTSTPQVMCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBI5</accession>
    <name>A0A670KBI5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KBI5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036223.1">
        <property type="protein sequence ID" value="ENSPMRP00000034156.1"/>
        <property type="gene ID" value="ENSPMRG00000022157.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003231"/>
    <dbReference type="OMA" id="SCRRRTW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051773">
        <property type="entry name" value="XK-related_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14297:SF8">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE ADAPTER PROTEIN XK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14297">
        <property type="entry name" value="MEMBRANE TRANSPORT PROTEIN XK FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025506024" description="XK-related protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="126" mass="14276" checksum="942D08A807458751" modified="2020-06-17" version="1">MKFPGSVLVSLFLFVAETALALYLSSTYRSAGDRIWQSLTLLFALLPCVLVQFSLVFIHRDLSKDRPLVLLLHILQLGPLVRWVGGVGPDPRRCSCRRRTWPGRKGGQGRGSPPQLRWKISTFWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KC44</accession>
    <name>A0A670KC44_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAM20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KC44"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037157.1">
        <property type="protein sequence ID" value="ENSPMRP00000035043.1"/>
        <property type="gene ID" value="ENSPMRG00000022677.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182951"/>
    <dbReference type="OMA" id="RQCCIIK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070166">
        <property type="term" value="P:enamel mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10314">
        <property type="entry name" value="FAM20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF25">
        <property type="entry name" value="FAM20 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025431371" description="FAM20 C-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="33"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="FAM20 C-terminal" evidence="10">
        <location>
            <begin position="305"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="341"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="531" mass="60749" checksum="1BC6DD68D7E80E2E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCC6</accession>
    <name>A0A670KCC6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat domain 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">WDR5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR5/wds family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028571308.1">
        <property type="nucleotide sequence ID" value="XM_028715475.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028571310.1">
        <property type="nucleotide sequence ID" value="XM_028715477.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028571311.1">
        <property type="nucleotide sequence ID" value="XM_028715478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KCC6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037235.1">
        <property type="protein sequence ID" value="ENSPMRP00000035118.1"/>
        <property type="gene ID" value="ENSPMRG00000022732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589250"/>
    <dbReference type="KEGG" id="pmua:114589250"/>
    <dbReference type="CTD" id="11091"/>
    <dbReference type="GeneTree" id="ENSGT00940000154143"/>
    <dbReference type="OMA" id="CKGHDTA"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000029">
        <property type="entry name" value="WD repeat-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="6">
        <location>
            <begin position="40"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="252"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="334" mass="36611" checksum="EB0B6DF574BC544B" modified="2020-06-17" version="1">MATEEKKPDSESTKTQSTPSSSTNQSKPAPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCV2</accession>
    <name>A0A670KCV2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="primary">CACNA1C</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="28">Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.</text>
    </comment>
    <comment type="function">
        <text evidence="31">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="24">Cell membrane</location>
            <location evidence="24">Sarcolemma</location>
            <location evidence="24">T-tubule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="31">Membrane</location>
            <topology evidence="31">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Postsynaptic density membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000037395.1">
        <property type="protein sequence ID" value="ENSPMRP00000035268.1"/>
        <property type="gene ID" value="ENSPMRG00000017019.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156127"/>
    <dbReference type="OMA" id="CMQNGTK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990454">
        <property type="term" value="C:L-type voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051393">
        <property type="term" value="F:alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086056">
        <property type="term" value="F:voltage-gated calcium channel activity involved in AV node cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061577">
        <property type="term" value="P:calcium ion transmembrane transport via high voltage-gated calcium channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002520">
        <property type="term" value="P:immune system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098912">
        <property type="term" value="P:membrane depolarization during atrial cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098911">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000009">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000021">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000037">
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    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000051">
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    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000060">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000069">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031688">
        <property type="entry name" value="CAC1F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005451">
        <property type="entry name" value="VDCC_L_a1csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF10">
        <property type="entry name" value="VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16885">
        <property type="entry name" value="CAC1F_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01630">
        <property type="entry name" value="LVDCCALPHA1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01635">
        <property type="entry name" value="LVDCCALPHA1C"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 29 31" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 31" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="7 31" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0966">Cell projection</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20 30" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="23" id="KW-0407">Ion channel</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 29" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="14 31" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="798"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="970"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1047"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1080"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1110"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1214"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1308"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="34">
        <location>
            <begin position="1466"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="571"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1584"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1952"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="32">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="1584"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="1607"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="1954"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="942"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="30">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00024012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00024028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00034112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00045450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1983" mass="224640" checksum="60945909E8F1E534" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIB9</accession>
    <name>A0A670KIB9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="9">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CLPP</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Protease component of the ClpXP complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The ClpXP complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Fourteen CLPP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity. Component of the ClpXP complex formed by the assembly of two CLPP heptameric rings with two CLPX hexameric rings, giving rise to a symmetrical structure with two central CLPP rings flanked by a CLPX ring at either end of the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A670KIB9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039278.1">
        <property type="protein sequence ID" value="ENSPMRP00000037093.1"/>
        <property type="gene ID" value="ENSPMRG00000023877.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005830"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0720">Serine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="296" mass="32436" checksum="2B0F748EA6EA736F" modified="2020-06-17" version="1">MVHRGGVATPAPRPSSRDSRAVFLPPPLFKINHVGRWKARKTFRGSMLQRIVHPLRLGSHVLSVARSLHQSPRSHIPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDNVASLVIAQLLFLQSESNKKPIHMYINSPGGAVTSGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGSPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEILKLKKQINALYAKHTKQSLDVIEAAMERDRYMSPVEAQEFGILDKVLVHPPHDGEDEPELVQKEAPPAPAPTSSSAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIY0</accession>
    <name>A0A670KIY0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spexin hormone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SPX</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KIY0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039205.1">
        <property type="protein sequence ID" value="ENSPMRP00000037021.1"/>
        <property type="gene ID" value="ENSPMRG00000023835.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012501"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904306">
        <property type="term" value="P:positive regulation of gastro-intestinal system smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028126">
        <property type="entry name" value="Spexin"/>
    </dbReference>
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        <property type="entry name" value="SPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28590:SF1">
        <property type="entry name" value="SPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15171">
        <property type="entry name" value="Spexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025556854" evidence="6">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="169" mass="19115" checksum="C98F5765ACDBB31A" modified="2020-06-17" version="1">LQGLHRGTATALALLLSACFITFSRTAPQDHFQRRNWTPQAMLYLKGAQGRRFISEESQRKDLYDRLQLETRSQNTNPLTLPEAVALFLSSLQKAHEEGNISFRSRSSFSSFLLIESNLPLLCHLQGPFLVQFLHCDPLGFITAVAIKCMCALCHEIKNHPVICVSRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJW9</accession>
    <name>A0A670KJW9_PODMU</name>
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        <recommendedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KJW9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038101.1">
        <property type="protein sequence ID" value="ENSPMRP00000035954.1"/>
        <property type="gene ID" value="ENSPMRG00000023225.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014757"/>
    <dbReference type="OMA" id="YQLTEHE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000050">
        <property type="entry name" value="Cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="118"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="871" mass="96940" checksum="B9416FB37946C265" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKI9</accession>
    <name>A0A670KKI9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 33B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">VPS33B</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028561906.1">
        <property type="nucleotide sequence ID" value="XM_028706073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KKI9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037369.1">
        <property type="protein sequence ID" value="ENSPMRP00000035242.1"/>
        <property type="gene ID" value="ENSPMRG00000022814.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584317"/>
    <dbReference type="KEGG" id="pmua:114584317"/>
    <dbReference type="CTD" id="26276"/>
    <dbReference type="GeneTree" id="ENSGT00940000156813"/>
    <dbReference type="OMA" id="QVHIYMI"/>
    <dbReference type="OrthoDB" id="10262528at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031091">
        <property type="term" value="C:platelet alpha granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032963">
        <property type="term" value="P:collagen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035855">
        <property type="term" value="P:megakaryocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032400">
        <property type="term" value="P:melanosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070889">
        <property type="term" value="P:platelet alpha granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090330">
        <property type="term" value="P:regulation of platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043589">
        <property type="term" value="P:skin morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.850:FF:000001">
        <property type="entry name" value="vacuolar protein sorting-associated protein 33B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000005">
        <property type="entry name" value="vacuolar protein sorting-associated protein 33B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000004">
        <property type="entry name" value="vacuolar protein sorting-associated protein 33B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="617" mass="70520" checksum="83B6BC0845BB5FFF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KNJ1</accession>
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        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="primary">LOC114605418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028602534.1">
        <property type="nucleotide sequence ID" value="XM_028746701.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028746702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KNJ1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038751.1">
        <property type="protein sequence ID" value="ENSPMRP00000036582.1"/>
        <property type="gene ID" value="ENSPMRG00000023587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605418"/>
    <dbReference type="KEGG" id="pmua:114605418"/>
    <dbReference type="GeneTree" id="ENSGT01150000286901"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="term" value="C:basolateral plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:bile acid transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006789">
        <property type="term" value="P:bilirubin conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:establishment of localization in cell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:gene expression"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098657">
        <property type="term" value="P:import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905431">
        <property type="term" value="P:microcystin transport"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:peptide transport"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:response to heat"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to mechanical stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904640">
        <property type="term" value="P:response to methionine"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to pain"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to toxic substance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:sodium-independent organic anion transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF89">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="46"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
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            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="699" mass="76211" checksum="6E94646592BA989E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HKJ3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HKJ3"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="69" mass="7505" checksum="F16F154F0F4F02E1" modified="2020-06-17" version="1">MEAPSAQQLEALKYGELRRLAKSAGLKANLKVRGLRAVKRAYPLHPFVYKLGVGFCCPTPQGYSSALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HM96</accession>
    <name>A0A670HM96_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LSM2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HM96"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000647.1">
        <property type="protein sequence ID" value="ENSPMRP00000000616.1"/>
        <property type="gene ID" value="ENSPMRG00000000466.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016597"/>
    <dbReference type="OMA" id="DNISCTD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000053">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025609883" description="U6 snRNA-associated Sm-like protein LSm2" evidence="10">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="91" mass="10750" checksum="FE2FABF48871D9F1" modified="2020-06-17" version="1">MHLWLFYSFFKSLVGKDVVVELKNDLRYDWYLNIKLTDISVTDPEKYPHMLSVKNCFIRGSVVRYVQLPADEVDTQLLQDAARKEALQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNM8</accession>
    <name>A0A670HNM8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger BED domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114592150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HNM8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001547.1">
        <property type="protein sequence ID" value="ENSPMRP00000001459.1"/>
        <property type="gene ID" value="ENSPMRG00000001092.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161131"/>
    <dbReference type="OMA" id="ICMARIV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF9">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="277"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="891" mass="99083" checksum="6EEBC5F25DF9A5DC" modified="2020-06-17" version="1"> </sequence>
</entry>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Sabatino S.J."/>
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                <person name="Pellitteri-Rosa D."/>
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                <person name="Bunikis I."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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                <person name="While G.M."/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="135" mass="15377" checksum="31044FE51CAAC88A" modified="2020-06-17" version="1">MEDNLTRLRGIAKEAARDRQTNTEMQRQDNFQLAWIAAKSNCKQHFLPTKGREPGFRGVGWVLFSFSAGPSKHLHVPFTTLPALFPTQANKLSLSHQQKAMIEHSVFVLHIWVRLEGLTYQALQQSTKSQALPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
                <person name="Andersson L."/>
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            <authorList>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045638">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019827">
        <property type="term" value="P:stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="497"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="897"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="828"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="916"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="978"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1189" mass="135001" checksum="A10EAAADEA376C97" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HV94</accession>
    <name>A0A670HV94_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dual specificity protein phosphatase 10</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DUSP10</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer. Interacts with MAPK14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028580422.1">
        <property type="nucleotide sequence ID" value="XM_028724589.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028580423.1">
        <property type="nucleotide sequence ID" value="XM_028724590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HV94"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003888.1">
        <property type="protein sequence ID" value="ENSPMRP00000003628.1"/>
        <property type="gene ID" value="ENSPMRG00000002537.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594643"/>
    <dbReference type="KEGG" id="pmua:114594643"/>
    <dbReference type="CTD" id="11221"/>
    <dbReference type="GeneTree" id="ENSGT00940000157671"/>
    <dbReference type="OMA" id="KKMTKCT"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048273">
        <property type="term" value="F:mitogen-activated protein kinase p38 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010633">
        <property type="term" value="P:negative regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050680">
        <property type="term" value="P:negative regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905042">
        <property type="term" value="P:negative regulation of epithelium regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060266">
        <property type="term" value="P:negative regulation of respiratory burst involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032873">
        <property type="term" value="P:negative regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048709">
        <property type="term" value="P:oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045591">
        <property type="term" value="P:positive regulation of regulatory T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002819">
        <property type="term" value="P:regulation of adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090335">
        <property type="term" value="P:regulation of brown fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14567">
        <property type="entry name" value="DSP_DUSP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000028">
        <property type="entry name" value="Dual specificity phosphatase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000013">
        <property type="entry name" value="Dual specificity phosphatase 10 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF299">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="18">
        <location>
            <begin position="164"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="320"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="383"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="481" mass="52443" checksum="8F9166EEFA53DA95" modified="2020-06-17" version="1">MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLDSASSASESHVSLLSTAVVSLKAANLTYMPSSNGSARSLSCGCSSASCCTVATYDKDNQAQTQASTSSTSANVGTSTTCPANQMVNNNENSGPLSPSSGVGSPVSGPTKQLPSVKIIYPNELAKKMTKCSKTHQGPVIIDCRPFMEYNKSHIQGAVHINCSDKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIVVYDENTNEPSRVIPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECPEGGGGGGAAAAVTCTLPQSIPTTPDIENAELTPILPFLFLGNEHDAQDLEKMQRLNIGYVINVTTHLPLYHYEKGLLNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLIGVETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HVP2</accession>
    <name>A0A670HVP2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Activator of 90 kDa heat shock protein ATPase homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">AHSA1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028574548.1">
        <property type="nucleotide sequence ID" value="XM_028718715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HVP2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003855.1">
        <property type="protein sequence ID" value="ENSPMRP00000003596.1"/>
        <property type="gene ID" value="ENSPMRG00000002514.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591553"/>
    <dbReference type="KEGG" id="pmua:114591553"/>
    <dbReference type="CTD" id="10598"/>
    <dbReference type="GeneTree" id="ENSGT00940000155144"/>
    <dbReference type="OMA" id="HIAMKWR"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036506">
        <property type="term" value="P:maintenance of unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.20:FF:000001">
        <property type="entry name" value="Activator of 90 kDa heat shock protein ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000018">
        <property type="entry name" value="Activator of 90 kDa heat shock protein ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF7">
        <property type="entry name" value="ACTIVATOR OF 90 KDA HEAT SHOCK PROTEIN ATPASE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="15">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="340" mass="38498" checksum="CD527F753A7F1DA3" modified="2020-06-17" version="1">MAKWGEGDPRWIVEQRADATNVNNWHWTERDASNWSSEKLKSLLLAIRAENAEGTCEVTEVSKLDGEASINNRKGKLIFFYEWNIKLTWTGTSNTGVKYKGYVEIPNLSDENDVDEIEISVSLAKDEPDTNLLALMKHEGVNQISSALETYISTLKTEFTQGMILPTVNGEQSELPPQPVRKAEERKTTEPVAGNALKSKSIGVKIPTCKINLKDVFLTSPDELYRVFITQEMVQAFTHSPAFLEADKGGKFQLLDGSVTGEFTELVPEKQIAMKWRFKTWPEGHFATITLTFIDKAGETEIRLEGRGIPANEEERTREGWQRYYFEGIKQTFGYGARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HVZ6</accession>
    <name>A0A670HVZ6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SAM domain-containing protein SAMSN-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SAM domain, SH3 domain and nuclear localization signals protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SAMSN1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FASLG. Interacts with phosphotyrosine containing proteins. Interacts (via SH3 domain) with CTTN. Interacts (phosphorylated at Ser-23) with YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ and SFN. Interacts directly with SAP30 and HDAC1. Identified in a complex with SAP30 and HDAC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028582769.1">
        <property type="nucleotide sequence ID" value="XM_028726936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HVZ6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003979.1">
        <property type="protein sequence ID" value="ENSPMRP00000003716.1"/>
        <property type="gene ID" value="ENSPMRG00000002586.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595994"/>
    <dbReference type="KEGG" id="pmua:114595994"/>
    <dbReference type="CTD" id="64092"/>
    <dbReference type="GeneTree" id="ENSGT00940000157806"/>
    <dbReference type="OMA" id="TDMDLPH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:ruffle"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:phosphotyrosine residue binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of adaptive immune response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of B cell activation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="SAM_SAMSN1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative sam and sh3 domain-containing protein 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM domain, SH3 domain and nuclear localization signals 1"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
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        <property type="entry name" value="SAMSN1_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF4">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN SAMSN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12485">
        <property type="entry name" value="SPIDER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="168"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="16">
        <location>
            <begin position="246"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="377" mass="41825" checksum="1ACE648ED95599C6" modified="2020-06-17" version="1">MLKRKPSNASDKEKTQKPKRASSFGNFDQRRHQSVSKPDDSSEICEADAVSDGGELGHSKSPNSGGSLGKKMRAISMTMKKKMGKKYIKALSEEMNDEGRDDSCSNRNSDPGGGSGTEKASLKASDSMDSLYSLNSGQSSSSGVTSCSDGTSNRDSLRLDDEVPYTGPFCGRAKVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGLLNNKVGNFKFIYVDLITEEESVPRKIKPHKRSKRAKPNSLQELLDRLHLQDYSSTLLLNGYETLEDLKDLKESHLIELNIENPEDRTRLLSAIENLQDYENEQDQEAEQVPQTLSPDLSFNKSQLNDCPRDSGCYISPENSDNSKEDLDTENLPDMVRAITITESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWF4</accession>
    <name>A0A670HWF4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670HWF4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004131.1">
        <property type="protein sequence ID" value="ENSPMRP00000003866.1"/>
        <property type="gene ID" value="ENSPMRG00000002666.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="RT_dom"/>
    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="376" mass="43695" checksum="5E5A63E7F393F6BF" modified="2020-06-17" version="1">MRWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTTDWFKIGKGVRQGCILSPCLFNLYAEFIMRKAGLDESQAGIKIAGRNINNLRYADDTTLMAESEEELKNLLMRVKEESAKYGLKLNIKKTKIMATGPITSWQIEGEEMEAVRDFIFLGSMITADGDSSHEIKRRLLLGRKAMANLDNILKSRDITLPTKVRIVKAMVFPVVMYGSESWTIKKADRRRIDAFELWCWRRLLRVPWTARRSNASILKEIRPECSLEGQIVNLRLQYFGHLMRREDSLEKTLMLGKMEGTRRRGRQRMRWLDSVLEATNMSLTKLREAVEDRSAWRALVHGVTKSHRIIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXS6</accession>
    <name>A0A670HXS6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KIAA0586</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KIAA0586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HXS6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004807.1">
        <property type="protein sequence ID" value="ENSPMRP00000004509.1"/>
        <property type="gene ID" value="ENSPMRG00000003066.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012397"/>
    <dbReference type="OMA" id="SARNYHQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029246">
        <property type="entry name" value="TALPID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15721">
        <property type="entry name" value="KIAA0586 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15721:SF2">
        <property type="entry name" value="PROTEIN TALPID3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15324">
        <property type="entry name" value="TALPID3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="1018"/>
        </location>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1189" mass="129913" checksum="6645CE844A45E618" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HYZ8</accession>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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                <person name="Soler L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HZ68"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005231.1">
        <property type="protein sequence ID" value="ENSPMRP00000004906.1"/>
        <property type="gene ID" value="ENSPMRG00000003351.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158235"/>
    <dbReference type="OMA" id="CEEYRHG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000013">
        <property type="entry name" value="carboxypeptidase N catalytic chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF80">
        <property type="entry name" value="CARBOXYPEPTIDASE N CATALYTIC CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025535521" evidence="14">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="443" mass="49915" checksum="6FB29FFF92B21430" modified="2020-06-17" version="1">MSQWLWILGKVLLLARVAASVNFFHHRYEELVQALFDVKGACPYITRLYSIGRSVQGRHLYVLEFSDYPGIHEPMEPEFKYVANMHGNEVLGRELLLQLAEFLCEQYRHGNQRVTQLIHETRIHLLPTMNPDGYEVAAAQVPGNPLGYLVGRNNANGVDLNRNFPDLNTVMYYNEKQGGPNHHIPLPDNWRSQVEPETLAVIQWMKSYNFILSANLHGGAVVANYPYDKSQEQRSRSVWQAQNSPTPDDSLFQKLAKSYSYAHGTMHQGTNCGDIFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCEKFPPESSLVFEWRKNAEALITYIEEVHQGIKGLVSDDNNNRLAGAVISVKGIAHDVTSGEHGDYFRLLLPGTYTVTASADGYQPQTVTVTVGPAAPTEVTQLQKFTFSSRLVRRRPPSISINYCPTQPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I2H7</accession>
    <name>A0A670I2H7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I2H7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005992.1">
        <property type="protein sequence ID" value="ENSPMRP00000005632.1"/>
        <property type="gene ID" value="ENSPMRG00000003831.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286962"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="413"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="890" mass="98003" checksum="947A0B57ED24F48B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I390</accession>
    <name>A0A670I390_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Radial spoke head protein 9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RSPH9</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Kinocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the flagellar radial spoke RSP9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I390"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006835.1">
        <property type="protein sequence ID" value="ENSPMRP00000006413.1"/>
        <property type="gene ID" value="ENSPMRG00000004348.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018686"/>
    <dbReference type="OMA" id="TFYHVPN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060091">
        <property type="term" value="C:kinocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120336">
        <property type="term" value="C:radial spoke head 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120338">
        <property type="term" value="C:radial spoke head 3"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062177">
        <property type="term" value="P:radial spoke assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055316">
        <property type="entry name" value="RSP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="336" mass="37279" checksum="C8FC22F65FFC5C0A" modified="2020-06-17" version="1">MKGCEGGGAGQDDKLPSNAERGPSPTSDLTSNAAPWKRLPGNGTQASGPALSGPHRHPSPAAMDAETLPYALDLVASSGVCLSPEKRAALRNSLLLVRRDYRFEQVRLWGRIQGTRGAYYIAEGVGPDRAGARSRLYSLNCVEWSLLPPPNEEFTALTSVLKGRFQGDPSYEYEHYEKKEEGERPYEEEATNLIKEEVRLVSAIDQIDKAVGIVPRGAYIKSPLGPVHENRNFEGLSLVEAKKLSSYFHFTEPVNLKNKTLLEKADLDPAIDFLDSLEHDIPKGSWSIQFERGGRVVVLRSLLWPGLTFYHVPNTKQHGYIYFGNAEKNLDLPFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5D9</accession>
    <name>A0A670I5D9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I5D9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007410.1">
        <property type="protein sequence ID" value="ENSPMRP00000006927.1"/>
        <property type="gene ID" value="ENSPMRG00000004722.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286962"/>
    <dbReference type="OMA" id="NIWIELP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="171"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="645" mass="71448" checksum="36789E844DC8AAA5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5V4</accession>
    <name>A0A670I5V4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="35">Multidrug resistance-associated protein 4</fullName>
            <ecNumber evidence="4">7.6.2.2</ecNumber>
            <ecNumber evidence="14">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="39" type="primary">ABCC4</name>
    </gene>
    <organism evidence="39 40">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="39 40" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="39" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="39" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82961"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:60129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>3',5'-cyclic AMP(in) + ATP + H2O = 3',5'-cyclic AMP(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:66185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:66189"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19121"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:19122"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29747"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:66397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>dehydroepiandrosterone 3-sulfate(in) + ATP + H2O = dehydroepiandrosterone 3-sulfate(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61364"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61365"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36252"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:66409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66400"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29746"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:66401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66380"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:82982"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:66381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>glycoursodeoxycholate(in) + glutathione(in) + ATP + H2O = glycoursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:132030"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:66417"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>leukotriene B4(in) + ATP + H2O = leukotriene B4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66424"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>prostaglandin E1(in) + ATP + H2O = prostaglandin E1(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:66393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>prostaglandin E2(in) + ATP + H2O = prostaglandin E2(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:66389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66412"/>
            <dbReference type="ChEBI" id="CHEBI:9407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:66413"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66404"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36257"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:66405"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>tauroursodeoxycholate(in) + glutathione(in) + ATP + H2O = tauroursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:132028"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:66421"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>urate(in) + ATP + H2O = urate(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16461"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:16462"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="34">Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); this interaction accelerates MRP4 internalization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Basolateral cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="4"/>
    <dbReference type="EC" id="7.6.2.3" evidence="14"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007611.1">
        <property type="protein sequence ID" value="ENSPMRP00000007115.1"/>
        <property type="gene ID" value="ENSPMRG00000004734.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153931"/>
    <dbReference type="OMA" id="ACAQWFH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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</entry>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF66">
        <property type="entry name" value="DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="8">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="6">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="269" mass="28960" checksum="CC63E1E60714E9BA" modified="2020-06-17" version="1">MESQDAAAQSLRAPKCSRCRNHGFVVPVKGHAGHCRWKQCPCEKCALITERQKIMAAQKALKRQGPDSPLREMLPPGQLNLSEPHNQGSVVQEGAKGTSAAVSHSMRTRTARTPPKPSSPTFIDLGMWSNQPQECTVVGPESVDRETPKVYPGYSGMYPYHPFSVGFTINQTGYRGPSPASVLPLQAGFRHFPSSHGPGGVASMPMQDVGGDFCPGYYTPLPPFIPQGFLPGIHYIPPPLPLNVVAEATKETSGKHSEGSVCCIADKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8V5</accession>
    <name>A0A670I8V5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TSPAN32</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028589518.1">
        <property type="nucleotide sequence ID" value="XM_028733685.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028589527.1">
        <property type="nucleotide sequence ID" value="XM_028733694.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028589533.1">
        <property type="nucleotide sequence ID" value="XM_028733700.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028589544.1">
        <property type="nucleotide sequence ID" value="XM_028733711.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028589554.1">
        <property type="nucleotide sequence ID" value="XM_028733721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I8V5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008802.1">
        <property type="protein sequence ID" value="ENSPMRP00000008235.1"/>
        <property type="gene ID" value="ENSPMRG00000005573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599098"/>
    <dbReference type="KEGG" id="pmua:114599098"/>
    <dbReference type="CTD" id="10077"/>
    <dbReference type="GeneTree" id="ENSGT00390000003287"/>
    <dbReference type="OMA" id="WAFCTSI"/>
    <dbReference type="OrthoDB" id="9886271at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070442">
        <property type="term" value="C:integrin alphaIIb-beta3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042832">
        <property type="term" value="P:defense response to protozoan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030886">
        <property type="term" value="P:negative regulation of myeloid dendritic cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042098">
        <property type="term" value="P:T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="243" mass="27652" checksum="061F2DDD7E79F424" modified="2020-06-17" version="1">MGQRYRVRAVKCQLLVASFFVMVLGVSLTILTIITYYGKHFTVISEVSLETNLYKRTLLHRGVFFAGICLSILLIIAALLSVVATVRELESAMAAVFFCFGVVFCASVKATYWSITNGIVAEDAMMDVYDIVYEDVRSNSSNTRRQELHTIHKTFLCCGKKLPFGEASRIEKEMCQSEAVGTEKDCLEEIQNFLKKHMTFVSVLMTITIFFMVYGMSLTLFLWYAIHFKKSLDRKGKYTLPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9Q3</accession>
    <name>A0A670I9Q3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Prolyl 4-hydroxylase subunit alpha-1</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">P4HA1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670I9Q3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008966.1">
        <property type="protein sequence ID" value="ENSPMRP00000008388.1"/>
        <property type="gene ID" value="ENSPMRG00000005669.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156635"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016222">
        <property type="term" value="C:procollagen-proline 4-dioxygenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
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        <property type="entry name" value="P4H_N"/>
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    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
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    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
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    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="TPR_P4H"/>
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        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-1"/>
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    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="17">
        <location>
            <begin position="455"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="578" mass="66093" checksum="D74DF6B2AB0785C1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9Z8</accession>
    <name>A0A670I9Z8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glucagon receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GCGR</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028715820.1"/>
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        <property type="nucleotide sequence ID" value="XM_028715830.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000009069.1">
        <property type="protein sequence ID" value="ENSPMRP00000008482.1"/>
        <property type="gene ID" value="ENSPMRG00000005725.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114589459"/>
    <dbReference type="CTD" id="2642"/>
    <dbReference type="GeneTree" id="ENSGT00940000157969"/>
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    <dbReference type="OrthoDB" id="5967113at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004967">
        <property type="term" value="F:glucagon receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucagon receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucagon receptor a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003290">
        <property type="entry name" value="GPCR_2_GLP1/glucagon_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003291">
        <property type="entry name" value="GPCR_2_glucagon_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF29">
        <property type="entry name" value="GLUCAGON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01353">
        <property type="entry name" value="GLUCAGNFAMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01354">
        <property type="entry name" value="GLUCAGONR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025327869" description="Glucagon receptor" evidence="17">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="18">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="137"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057279"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071417"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="498" mass="57612" checksum="CCF48DD9DEA667B6" modified="2020-06-17" version="1">MSQPRLLSILLALVVCPQGSSAQIMDFLFESWKAYSEECYHNMSLLPPSTELVCNRTFDKYSCWPDAQPNSTVNVSCPWYLPWYDQVKHGYVFKKCDPDGQWVTTPEGKSLRDAHQCVMNNETILEQEWFAKIYGSFKVMYTVGYSVSLCTLILALAVLLGFSKLHCMRNYIHMNLFASFILKGISVLIIDKLLNTHFNQKIDDYSVGLWPSDEAAARCRAATVFMQYGIVANYCWLLVEGLYLHNLLVLAVFSERSYFSLYLCIGWGAPVLFIVPWVVVKFLYENIQCWSTNHNMGFWWILRFPVFLAILINFFIFIRIIQILVSKLRAHQMRYTDYKFRLAKSTLTLIPLLGIHEVVFAFVTDEHAQGTLRYVKLFFDLFLSSFQGMLVAILYCFVNKEVQSELMKKWTRWKLGWDIEEEYKHTYSHTPHVRNGGTRTGEKHKLVGNYLNGLGRSQATMHTSTQYLERTACSASENLAVAEQPHCYEFPDTAESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBS2</accession>
    <name>A0A670IBS2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IBS2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009697.1">
        <property type="protein sequence ID" value="ENSPMRP00000009082.1"/>
        <property type="gene ID" value="ENSPMRG00000006108.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234712"/>
    <dbReference type="OMA" id="NACCINL"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="356" mass="40387" checksum="13CC217A0BF99C6E" modified="2020-06-17" version="1">AVAELTCVHLRREVPADWRRANVVPIFKKGKREDPNNYRPVSLTSIPGKILEQIIKQTVCEHLERNAVITNSQHGFLKNKSCQTNLISFFDRITSLVDEGNAVDVVYLDFSKAFDKVPHDILVKKLVKCGLDYATTQWICNWLTDRTQRVLINGSSSSWRRVTSGVPQGSVLGPVLFNIFINDLDDGLKGILIKFADDTKLGGVANTPEDRITLQNDLDRLENWAKTNKMNFNREKCKVLHLGKKNERHKYKMGDTWLESSTCEKDLGVLVDHKLDMSQQCDAAAKKANAILGCINRSLASRSREVIVPLYSALVRPHLEYCVQFWAPQFKKDTDKLERVQRRATKNGQRPGNDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IC13</accession>
    <name>A0A670IC13_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mbt domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MBTD1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028572224.1">
        <property type="nucleotide sequence ID" value="XM_028716391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IC13"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009876.1">
        <property type="protein sequence ID" value="ENSPMRP00000009251.1"/>
        <property type="gene ID" value="ENSPMRG00000006220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589940"/>
    <dbReference type="CTD" id="54799"/>
    <dbReference type="GeneTree" id="ENSGT00940000153840"/>
    <dbReference type="OMA" id="CVTMIVD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140117">
        <property type="term" value="F:histone H4K20me1 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140005">
        <property type="term" value="F:histone H4K20me2 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20120">
        <property type="entry name" value="MBT_MBTD1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20123">
        <property type="entry name" value="MBT_MBTD1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20126">
        <property type="entry name" value="MBT_MBTD1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20129">
        <property type="entry name" value="MBT_MBTD1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000010">
        <property type="entry name" value="MBT domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000015">
        <property type="entry name" value="MBT domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000019">
        <property type="entry name" value="MBT domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000032">
        <property type="entry name" value="MBT domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.160:FF:000001">
        <property type="entry name" value="MBT domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012313">
        <property type="entry name" value="Znf_FCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038603">
        <property type="entry name" value="Znf_FCS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF79">
        <property type="entry name" value="MBT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21319">
        <property type="entry name" value="zf-FCS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51024">
        <property type="entry name" value="ZF_FCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FCS-type" evidence="13">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="11">
        <location>
            <begin position="165"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="11">
        <location>
            <begin position="277"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="11">
        <location>
            <begin position="375"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="11">
        <location>
            <begin position="488"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="652" mass="73034" checksum="98FC473BCEF5C6DC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ID41</accession>
    <name>A0A670ID41_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL19m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L19, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPL19</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ID41"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010278.1">
        <property type="protein sequence ID" value="ENSPMRP00000009636.1"/>
        <property type="gene ID" value="ENSPMRG00000006445.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009415"/>
    <dbReference type="OMA" id="IHEIQVV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="39S ribosomal protein L19, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="250" mass="29208" checksum="C439C8F2292B66AC" modified="2020-06-17" version="1">SKDGEPAKFKPPPKPVIVDESKTQTTETRFLSPEFIPPRQRTNPFKFYLERSDMIQRRKVMNIPEFYVGSILSVSAADPHASGKSSTFVGLCIQRSGKGLGATFILRNIIEGQGIEICYELYNPLIQEIKVLKLEKRLDDNLMYLRDALPEYSTVDVNMKAVPLSAMEEVPVNKVMKVRMKPKPWSKRWEHPKFNIQGINFDLYLNERHKAKVEKWQMPWNEFDMLKKYDTLEIEKKIWEEVNEELKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670II87</accession>
    <name>A0A670II87_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Abnormal fluorescence under UV illumination</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670II87"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011811.1">
        <property type="protein sequence ID" value="ENSPMRP00000011057.1"/>
        <property type="gene ID" value="ENSPMRG00000007371.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008033"/>
    <dbReference type="OMA" id="WEEDMNA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="285" mass="31648" checksum="192ECE5E393B8282" modified="2020-06-17" version="1">ENSFSPAEAYSEISSSCSPVDKEVAVQLDEEDELKHLRACFHIPRVKDLPPTNLALVHKNETCVYFAGNSLGLQPKKVKTYLDEELDKWAKLGVHGHFTGKRPWALGDECIVELVADIVGAHKEEVALMNGLTVNLHLLMLSFFKPTADRYKILLEAKAFPSDHYAVESQLQFHGLDMESSMLMIEPQEGEETLRTEDILAVIEKEGDSIAIILFSGVQYYTGQLFDIPRITKAGQEKGCFVGFDLAHAVVDFACWCSYKYLNSGAGGLAGAFIHEKHSQTVKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIR5</accession>
    <name>A0A670IIR5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Leukotriene B4 receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114602920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IIR5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012757.1">
        <property type="protein sequence ID" value="ENSPMRP00000011945.1"/>
        <property type="gene ID" value="ENSPMRG00000007981.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182966"/>
    <dbReference type="OMA" id="CMYASIN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004974">
        <property type="term" value="F:leukotriene receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000109">
        <property type="entry name" value="Leukotriene B4 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF946">
        <property type="entry name" value="LEUKOTRIENE B4 RECEPTOR 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="45"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="333" mass="37196" checksum="C5904D1E0CB6CC98" modified="2020-06-17" version="1">MRSTMALNSSTETGLNNTGMDTLWVQHTLLPNLILSACFLTGIPGNSFVLWIILTKFPQRSFTIALILNLAMADLMALLTVPFWIYDFATSWNFGEASCKLLVYFNYLTMYASIFLITLMSLHRFAVVVLPVASKRWQRPHVVYITFVGVWLLAVAFASPTLIFTSSQNVEGDCSDDVYGAQWQQIVDNVVETLFSFVIPFAVIAICYSCVARKVGTLKFHQKMKTKKLILAVVGGFFVCWLPYHIFSLLTVCALLLQSTFPGVAKTLDHADKVVSNIHWAVAFLSSTVNPILYAFAAQSFRGELQGTGFAKLFFKLHEDTDETSANTTTTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJD0</accession>
    <name>A0A670IJD0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">KLF transcription factor 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KLF12</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028584202.1">
        <property type="nucleotide sequence ID" value="XM_028728369.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028584203.1">
        <property type="nucleotide sequence ID" value="XM_028728370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IJD0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012963.1">
        <property type="protein sequence ID" value="ENSPMRP00000012143.1"/>
        <property type="gene ID" value="ENSPMRG00000008118.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596602"/>
    <dbReference type="KEGG" id="pmua:114596602"/>
    <dbReference type="CTD" id="11278"/>
    <dbReference type="GeneTree" id="ENSGT00940000158108"/>
    <dbReference type="OMA" id="LNNAMML"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21441">
        <property type="entry name" value="KLF12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000563">
        <property type="entry name" value="Krueppel-like factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF56">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="14"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="70"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="379" mass="41528" checksum="3DB14B8F93C13490" modified="2020-06-17" version="1">MLMLDGMPAVRVKTELLESEQGSPNSHSYPDMEAVPLLLNSMKADPEEDSLSTDHFQTQTEPVDLSINKARSSPIAASSSPVSITASASSPSSTSTSSSRPASSPTVITSVSSASSAPSVLTPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQTNKMSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRSHVKAQMDPRGLSPRQIKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEESMWGCARSAVNTFRFFNSSSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKS4</accession>
    <name>A0A670IKS4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CHST4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A670IKS4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013470.1">
        <property type="protein sequence ID" value="ENSPMRP00000012610.1"/>
        <property type="gene ID" value="ENSPMRG00000008446.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162746"/>
    <dbReference type="OMA" id="YMKPGPR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000703">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016469">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF40">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005883">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="13">
        <location>
            <begin position="42"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="389" mass="44641" checksum="B644A53F31B56BE4" modified="2020-06-17" version="1">RWLPLTRLIVLVILAIQVIALTFWFQLHGRKCPLAQEPSQVHILILSSWRSGSSFVGQLFSQHPDAFYMMEPAWHVWATMYQNSAKVLHMAVRDLIRSVFKCDMSVFDVYLPQKRNVSDLFQWEVSRALCSPPVCNSFQRSDFISKHACKTLCRKSPFSKVEEACRSYSHVVLKVVRIFDLKVLYPLLNDPSLNLKIIHLVRDPRAVFHSRKNTGGSLARDTRIVLRHKRNAMDTEPYAAMQEICRQALPSTLQDRYLLVRYEDIASNPLAKAAQLYSFAGLPFSPNLQSWVHNITHGQGLGKQAFDVDSRDAVNVSQAWRKALPYLQIAKLQEVCKDALKLLGYPLVKSEEEQKNMALDLFYAQTPLVNQESKRSLEPSPAISWTWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKZ1</accession>
    <name>A0A670IKZ1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Progestin and adipoQ receptor family member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PAQR7</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IKZ1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013082.1">
        <property type="protein sequence ID" value="ENSPMRP00000012254.1"/>
        <property type="gene ID" value="ENSPMRG00000008201.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161438"/>
    <dbReference type="OMA" id="CHSISCT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF41">
        <property type="entry name" value="MEMBRANE PROGESTIN RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="536" mass="60005" checksum="9926D3AB5DC6D272" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IMD5</accession>
    <name>A0A670IMD5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="6">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">ACVR1C</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <reaction evidence="22">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
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    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
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        <cofactor evidence="2">
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="GS_dom"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
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    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF58">
        <property type="entry name" value="ACTIVIN RECEPTOR TYPE-1C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
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        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 24 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="21" id="KW-0464">Manganese</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 24 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8 25" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
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    <feature type="domain" description="GS" evidence="28">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
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    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="148"/>
            <end position="440"/>
        </location>
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    <feature type="binding site" evidence="24">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51256"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012851.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="446" mass="50355" checksum="1045A533A085BE9E" modified="2020-06-17" version="1">MLTKNGRQEVIKACVSLPQLKAQIFCHSSKNITKTECCYTDFCNNITIHLPTGPDAARKSKLGPVELTVVITVPVCVLSIALMLTLCTHQGNNCRFRKKRRQNIEEPLSECSLVNPGKTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWRGKWCGEDVAVKIFSSRDERSWFREAEIYQTIMLRHENILGFIAADNKDNGTWTQLWLVSEYHDQGSLFDYLNNNTVTANGMIKMTFSIASGLAHLHMEIVGTQGKPAISHRDLKSKNILVKRNETCAIADLGLAVKHDSLLNTIDIPQNSRVGTKRYMAPEILDDTMNISIFESFKRADIYSLGLVYWEISRRCSVGGIVEEYQLPYYDAVPSDPSIEDMRKVVCEQKHRPNIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLYVQEDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IMS6</accession>
    <name>A0A670IMS6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GABA type A receptor associated protein like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GABARAPL2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IMS6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013421.1">
        <property type="protein sequence ID" value="ENSPMRP00000012567.1"/>
        <property type="gene ID" value="ENSPMRG00000008419.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155010"/>
    <dbReference type="OMA" id="QDWISIN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008429">
        <property type="term" value="F:phosphatidylethanolamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901799">
        <property type="term" value="P:negative regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070972">
        <property type="term" value="P:protein localization to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000396">
        <property type="entry name" value="GABARAPL2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="88" mass="10385" checksum="5DA8E3DC4DB05D2C" modified="2020-06-17" version="1">MKWMFKEDHALEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IMV1</accession>
    <name>A0A670IMV1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Uridine phosphorylase</fullName>
            <ecNumber evidence="4 12">2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UPP2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 12">Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:22824"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:22825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uridine + phosphate = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:24389"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="4 12"/>
    <dbReference type="RefSeq" id="XP_028602109.1">
        <property type="nucleotide sequence ID" value="XM_028746276.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028602118.1">
        <property type="nucleotide sequence ID" value="XM_028746285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IMV1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013746.1">
        <property type="protein sequence ID" value="ENSPMRP00000012874.1"/>
        <property type="gene ID" value="ENSPMRG00000008608.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605260"/>
    <dbReference type="KEGG" id="pmua:114605260"/>
    <dbReference type="CTD" id="151531"/>
    <dbReference type="GeneTree" id="ENSGT00940000161094"/>
    <dbReference type="OMA" id="HAQCHDV"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045098">
        <property type="term" value="C:type III intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047847">
        <property type="term" value="F:deoxyuridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006248">
        <property type="term" value="P:CMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006249">
        <property type="term" value="P:dCMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046050">
        <property type="term" value="P:UMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000009">
        <property type="entry name" value="Uridine phosphorylase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01719">
        <property type="entry name" value="euk_UDPppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF8">
        <property type="entry name" value="URIDINE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="13">
        <location>
            <begin position="57"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610059-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610059-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="323" mass="35873" checksum="2CB3BBB83724EA3B" modified="2020-06-17" version="1">MTFLLAGASKTEMNSYNGNGLVYVMNPHLDLMDEDILYHLDLGTKTHNLPAMFGDTKFVCVGGSPNRMKAFAQFMHKELGLEGDGKDIKDICAGTDRYCMYKVGPVLSISHGMGVPSISIMLHELIKLLHHAKCRDVTIIRIGTSGGLGIEPGSVVITDTAVDSFFKPQFEQVILDNVVTRSTELDRDLAEELLECSRQIKDFPSLIGHTMCTDDFYEGQGRLDGALCSFSREKKLEYLKRAYNAGVRNIEMESTVFAAMCRLCGLKAAVVCVTLLNRLEGDQITAPHEVLLDYQQRPQQLISLFIRKCLGLWNPNGLSEDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IMX8</accession>
    <name>A0A670IMX8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptor 83</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GPR83</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN. Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028581919.1">
        <property type="nucleotide sequence ID" value="XM_028726086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IMX8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013487.1">
        <property type="protein sequence ID" value="ENSPMRP00000012627.1"/>
        <property type="gene ID" value="ENSPMRG00000008457.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595634"/>
    <dbReference type="KEGG" id="pmua:114595634"/>
    <dbReference type="CTD" id="10888"/>
    <dbReference type="GeneTree" id="ENSGT00940000154336"/>
    <dbReference type="OMA" id="IYISVIW"/>
    <dbReference type="OrthoDB" id="5952899at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007631">
        <property type="term" value="P:feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051384">
        <property type="term" value="P:response to glucocorticoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15389">
        <property type="entry name" value="7tmA_GPR83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000191">
        <property type="entry name" value="Probable G-protein coupled receptor 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF57">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="95"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="431" mass="49362" checksum="FA9728B51F4C86BE" modified="2020-06-17" version="1">MLSSPMGTITCYMWLYLTHFSNSLVRSEKFAVNGSLGALFEVPNISHFLSWTNYTLADWQSFLEGKRYGSGSQNLLVKILLVVAYSVIIVFSLFGNALVCHVMVKNKRMHFATSLFIVNLAVADLMITFLNTPFTLARFVNSTWIFGKEMCHISRFAQYCSLHVSALTLTAIAIDRRQVILHPLKPRISTAKGLVCISIIWLMATCFSLPHAIYQKLFTFEYREEITRSLCLPNFPEPADLFWKYLDLTTFVLLYVLPLLIISITYVTIAKKLWFRTAIGVVMVEQYFALQRKKIMTIKMLMLVVVIFAVCWFPLNCYVLLLSSQVIHTNNGLYFAFHWLATSSTCYNPFIYCWLNENFRAELKTFLKVCRKSPDPREQRLPSPAGLPCRAAWPQRDHCKGLQVSLDLPSTSNFQLRKNDITAVQPIVAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INT3</accession>
    <name>A0A670INT3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670INT3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014217.1">
        <property type="protein sequence ID" value="ENSPMRP00000013317.1"/>
        <property type="gene ID" value="ENSPMRG00000008910.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000014221.1">
        <property type="protein sequence ID" value="ENSPMRP00000013321.1"/>
        <property type="gene ID" value="ENSPMRG00000008910.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000014224.1">
        <property type="protein sequence ID" value="ENSPMRP00000013324.1"/>
        <property type="gene ID" value="ENSPMRG00000008910.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154265"/>
    <dbReference type="OMA" id="LANFINM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000422">
        <property type="entry name" value="Guanylate-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="4">
        <location>
            <begin position="37"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="236" mass="26352" checksum="CA3F2C530A2973D8" modified="2020-06-17" version="1">MAPGQVHMEAPVCLIENMPDGKLVVNREAAEVLARIRQPVVVVAIAGLYRTGKSYLMNRLAGKRKGFCLGATVQGLTKGIWMWCLPHPHRPDLTLLLLDTEGLGDVQKGNTQNDSWIFALAILLSSTLVYNSMGTIDQNALENLHYVTELTKKIKAKASSGEDEEEENSAEFVRFFPDFIWAVRDFTLQLEIDGHPVTEDGYLENALRLQKGTVTARKKMQCLRWGEDTASLEVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQ13</accession>
    <name>A0A670IQ13_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C-type lectin domain containing 14A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CLEC14A</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028576116.1">
        <property type="nucleotide sequence ID" value="XM_028720283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IQ13"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014222.1">
        <property type="protein sequence ID" value="ENSPMRP00000013322.1"/>
        <property type="gene ID" value="ENSPMRG00000008913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592246"/>
    <dbReference type="KEGG" id="pmua:114592246"/>
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    <dbReference type="OrthoDB" id="9890094at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990430">
        <property type="term" value="F:extracellular matrix protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051505">
        <property type="entry name" value="C-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789:SF5">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 14 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789">
        <property type="entry name" value="CHONDROLECTIN VARIANT CHODLFDELTAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025567044" evidence="11">
        <location>
            <begin position="20"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="441" mass="45761" checksum="C0177437160AF460" modified="2020-06-17" version="1">MRGLVLASLVLLQPLPVPGGPTAALRPQSDHAWCHPSGSCYSVHVGSLSFPRAQEACAAHGGRLSTASGRVEVQAIVSLLRGVARGGSGASLFWLGLVRKAQQCTMEELPLRGFSWAAAGGLVAEARNESAAEGSLSWVKEPSKSCTTQKCAGLQVTWGEPRAAESWGLAEHACAKANAGYVCKYSYAGACRAPGAGSHLHYALPFRLQSAAVEFGPPGTVLTLRCPGREARFTCRLSPDGYRWEGTERGLCSCPSGYWSPSEGACVELADCFGARGAFLCLCAWGARLAADEKACVPPARTETPPSPALSPSPNGSSDGLPGRNDSLAATLPSEVGNSSSAPGAVSSNYLFILITVAVVTLVILVMAALQIFQACFRLCCSKGSQTKKDGAPATTATTADGDPEDSDHSLGPSKAESAEVSQDEPKPVAGQVEQEQPRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRB9</accession>
    <name>A0A670IRB9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain containing 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BTBD19</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IRB9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015549.1">
        <property type="protein sequence ID" value="ENSPMRP00000014555.1"/>
        <property type="gene ID" value="ENSPMRG00000009707.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162133"/>
    <dbReference type="OMA" id="NCLAIDE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd18494">
        <property type="entry name" value="BACK_BTBD19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042846">
        <property type="entry name" value="BTBD19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46965">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46965:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="240" mass="26970" checksum="641EF3543295E423" modified="2020-06-17" version="1">MGRVAGERGEQGRVLRSVDVTFLVGREQKEIFAHRCLLTSRCQALHAMLSHPQEMQAPLILSHVQPEVFLAVIEYLYTNNVTLNNSIAAVAYGQVDLQMHCLAFIESCTQDVVLTRGFLELSELAMQTILRSDCLAIDEVKLIRAVREWAHVGSAVLDRTVHDVAATVVPGLRLDLLSPSELTTLEEENKKDQMIPVESLAQAWKMHALRKGCGMRSSLCQRRRGTLSREHQRPLDPQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISP9</accession>
    <name>A0A670ISP9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 family 2 subfamily C member 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ISP9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015181.1">
        <property type="protein sequence ID" value="ENSPMRP00000014212.1"/>
        <property type="gene ID" value="ENSPMRG00000009477.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162064"/>
    <dbReference type="OMA" id="PMYTFYL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008392">
        <property type="term" value="F:arachidonate epoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019373">
        <property type="term" value="P:epoxygenase P450 pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11026">
        <property type="entry name" value="CYP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020469">
        <property type="entry name" value="Cyt_P450_CYP2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF424">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01957">
        <property type="entry name" value="EP450ICYP2F"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="49387" checksum="651A45660E5A25F2" modified="2020-06-17" version="1">MYTFHLGSRPCVVLSGYQVLKEALIDKAEEFSGRGDFPAVQMWSKGNGIVYGTGERWRQLRRFAISTFKNFGMGKRSIEERIKEEAQFLVAEFHKTEGKPFDPTFFLSCAGSNIICTLVFGDRFEYTDKKFLMLLDLINSNWKLMSSTWGQMLFSFPKIMKYVPGPHRQIYKNYLKLAKFVGERLEMNRQTLDVNNPRDFIDCFLIKIQQEKNNPDTHFNEDTMSKTTVNLFFAGTETVSSTLRYGLRILMRHPEVEEKLHEEIDRVIGVNRSPCMEDRSRMPYTDAVIHEIQRYADIVPMAVPHTVTRDVEFRGYTLPKDLNIIPLICTSQFDPTHFKNPTSFDPTHFLDENGRFKKNDAFMAFSAGKRVCLGESLAVMELFIFLTTILQNFKLKPLMKPEDIDITPESTGLGSIPRPYQFCLIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IT33</accession>
    <name>A0A670IT33_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC6A9</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glycine(out) + chloride(out) + 2 Na(+)(out) = glycine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70691"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028589563.1">
        <property type="nucleotide sequence ID" value="XM_028733730.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028589565.1">
        <property type="nucleotide sequence ID" value="XM_028733732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IT33"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016177.1">
        <property type="protein sequence ID" value="ENSPMRP00000015140.1"/>
        <property type="gene ID" value="ENSPMRG00000010103.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599117"/>
    <dbReference type="CTD" id="6536"/>
    <dbReference type="GeneTree" id="ENSGT00940000157263"/>
    <dbReference type="OMA" id="QHNGVQI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903804">
        <property type="term" value="P:glycine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061537">
        <property type="term" value="P:glycine secretion, neurotransmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001504">
        <property type="term" value="P:neurotransmitter uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070455">
        <property type="term" value="P:positive regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046985">
        <property type="term" value="P:positive regulation of hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060092">
        <property type="term" value="P:regulation of synaptic transmission, glycinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11498">
        <property type="entry name" value="SLC6sbd_GlyT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003028">
        <property type="entry name" value="Na/ntran_symport_glycine_GLY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF263">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01204">
        <property type="entry name" value="GLY1TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 14" id="KW-0769">Symport</keyword>
    <keyword evidence="5 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="636" mass="70814" checksum="091B054B9424E593" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITC8</accession>
    <name>A0A670ITC8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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        <text evidence="2">Belongs to the myelin P0 protein family.</text>
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    <dbReference type="PANTHER" id="PTHR13869:SF19">
        <property type="entry name" value="MYELIN PROTEIN ZERO-LIKE PROTEIN 1"/>
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    </dbReference>
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            <end position="183"/>
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        <location>
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            <dbReference type="PROSITE" id="PS50835"/>
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            <dbReference type="Ensembl" id="ENSPMRP00000014447.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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            <taxon>Bifurcata</taxon>
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            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
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                <person name="Perez I de Lanuza G."/>
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                <person name="Bellati A."/>
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                <person name="Bunikis I."/>
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                <person name="Marsik P."/>
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                <person name="While G.M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="492"/>
            <end position="766"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="1250" mass="147484" checksum="EDF26F5AF347D2EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUC0</accession>
    <name>A0A670IUC0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
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                <person name="While G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="140"/>
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            <begin position="203"/>
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            <begin position="243"/>
            <end position="266"/>
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            <begin position="278"/>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="318" mass="35882" checksum="DE3F9B651619F835" modified="2020-06-17" version="1">MTAKNQTQVTVFIFSGFTDHPELKAILFITFLAIYTITLGANLGMIILIRMDQQLQTPMYFFLSHLAFLDASYSSAVTPKAIWDLLAERKTISFAGCAAQFYMFDGLVMTEFFLLSVMAYDRYVAICNPLLYYVVMSKKFCTAAVASVYIYGFASSVVQTALTFQLSFCRSNVINHFYCNDPPLLALSCSDTRPKEIHHVTEMIISSLAGFTTIGSLFIIVFSYVFILAAILKIRSAQGRHKAFSTCTSHLTAVTVFYGTLIFTYLRPNTSYSLGRDQVASVFYTVVVPMLNPLIYSLRNKEVKEAFRQSVRMKMFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUS1</accession>
    <name>A0A670IUS1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IUS1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000015953.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="3"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="360" mass="41758" checksum="6C6DB80CA6077AF0" modified="2020-06-17" version="1">MARINIDILGISELKWTGMGEFSSDDHHIYYCGQETRKRNGVALIVNKRVAKPVLGCNLKNDRMISIRIQGRPFNITVIQVYAPTTGAEETEIDQFYEDLQHLIEVTPKKDVLLIIGDWNAKVGSQEIKGTTGKFGLGDQNEAGQRLIEFCQENKLVITNTLFQQHKRRLYTWTSPDGQHRNQIDYILCSQRWRSSIQSAKTRPGADCGSDHQLLIAKFKLKLKKVGKTTGPVRYNLNQIPYEYTVEVRNRFKDLDLVDRVPEELWMEALNIVQEAATKTIPMKRKCKKAKWLSNEALQIAEERRQAKCEGDSERYRRLNADFQRIARRDKKAFLNEQCKEIEENNRMGRTRDLSRKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IW21</accession>
    <name>A0A670IW21_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microtubule-associated protein 1A/B/S-like MBL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IW21"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017462.1">
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        <property type="gene ID" value="ENSPMRG00000010918.1"/>
    </dbReference>
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    <dbReference type="OMA" id="CHHEVAS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031114">
        <property type="term" value="P:regulation of microtubule depolymerization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843:SF5">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25281">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microtubule-associated protein 1A/B/S-like MBL-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="236" mass="26399" checksum="C3C26F014584333D" modified="2020-06-17" version="1">MEGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNSDWMKNLISPDLGVVFLNAPESLGNPDPNFQLKRSVEEACFTLQYLNKLSVKPEPLFRNVANSTEPIILFQKMGVGKLEMYVLNPVKSSKEMQYFMHQWTGTSKDKAELVLPNGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZG2</accession>
    <name>A0A670IZG2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cilia- and flagella-associated protein 57</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 65</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CFAP57</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Associates with components of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility, and might act as an inner dynein arm (IDA) hub or linkage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">May form homodimers. Associates with components of the nexin-dynein regulatory complex (N-DRC) and the CFAP184:CFAP263 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CFAP57 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IZG2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018703.1">
        <property type="protein sequence ID" value="ENSPMRP00000017568.1"/>
        <property type="gene ID" value="ENSPMRG00000011599.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00620000088018"/>
    <dbReference type="OMA" id="FPHCNAV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:sperm flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="AGAP008095-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cilia and flagella associated protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000271">
        <property type="entry name" value="cilia- and flagella-associated protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052993">
        <property type="entry name" value="CFA-57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="15">
        <location>
            <begin position="393"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="634"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="694"/>
            <end position="873"/>
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    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="917"/>
            <end position="1052"/>
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    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1108"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00061460"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00064509"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00074539"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00075729"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017568.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1261" mass="145976" checksum="B0499BD4E521B663" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1M7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="primary">LOC114604312</name>
    </gene>
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        <name type="common">Wall lizard</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018136.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J381</accession>
    <name>A0A670J381_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Round spermatid basic protein 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RSBN1L</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
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                <person name="Salvi D."/>
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                <person name="While G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the round spermatid basic protein 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J381"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019831.1">
        <property type="protein sequence ID" value="ENSPMRP00000018665.1"/>
        <property type="gene ID" value="ENSPMRG00000012244.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001969"/>
    <dbReference type="OMA" id="WPAQPRI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026306">
        <property type="entry name" value="RSBN1/Dpy-2/CEP530"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354:SF9">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE RSBN1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354">
        <property type="entry name" value="ROUND SPERMATID BASIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="613" mass="70070" checksum="D505E01FA1086C56" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5N5</accession>
    <name>A0A670J5N5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-galactosidase</fullName>
            <ecNumber evidence="15">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114584858</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1)-Cer(d18:1(4E)) + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:21112"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17950"/>
            <dbReference type="ChEBI" id="CHEBI:18313"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a globoside Gb3Cer + H2O = a beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:48020"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:79208"/>
            <dbReference type="ChEBI" id="CHEBI:88154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:48021"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_028562842.1">
        <property type="nucleotide sequence ID" value="XM_028707009.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028562843.1">
        <property type="nucleotide sequence ID" value="XM_028707010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J5N5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020800.1">
        <property type="protein sequence ID" value="ENSPMRP00000019581.1"/>
        <property type="gene ID" value="ENSPMRG00000012779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584858"/>
    <dbReference type="KEGG" id="pmua:114584858"/>
    <dbReference type="GeneTree" id="ENSGT00390000008751"/>
    <dbReference type="OMA" id="NIIDWFF"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046479">
        <property type="term" value="P:glycosphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000070">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000017">
        <property type="entry name" value="Alpha-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035373">
        <property type="entry name" value="Melibiase/NAGA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF93">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17450">
        <property type="entry name" value="Melibiase_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025443369" description="Alpha-galactosidase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase A C-terminal" evidence="17">
        <location>
            <begin position="313"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="407" mass="45094" checksum="A9E346FD222CAA36" modified="2020-06-17" version="1">MLHFSLGILLGLAACCASLDNGLLKTPPMGWVPWERFRCNTDCKNDPDNCISEHLIKAMADRLAGDGWLRLGYKYVNLDDCWAANKRDAQGRLQPNPERFPSGIKALADYVHSKGLKFGIYSDLGSKTCSGYPGTTLDTIETDAKTFAEWGVDMLKLDGCFSNSSIKAAGYPKMSAALNKTGRPIAFSCSWPAYEGGLPPKVNYTLLGKICNLWRNFGDIEDSWDSLFHIIEWYGNHQDIIQPVAGPGRWNDPDTLIIGNFGLSYEQSKVQVALWAVLAAPFFMSCNLRTISTEAKNILQNPLLIYINQDNLGIQGKRIAKSQHLEVWKRPLVNGQFAVAVMNNGTDGTPKPIVTTLGLLGILDCKAGYKVYEVLEKLFMGTYKLNDPIRTKVPPTGVVLFFLRPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J7Y3</accession>
    <name>A0A670J7Y3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670J7Y3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021000.1">
        <property type="protein sequence ID" value="ENSPMRP00000019769.1"/>
        <property type="gene ID" value="ENSPMRG00000012897.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="CADHKKL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="409" mass="46964" checksum="D52A29F2E1C92064" modified="2020-06-17" version="1">MSTATPESSVTGPNGQGSLYLYLSPSANKQIANMRWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTTDWFKIGKGVRQGCILSPCLFNLYAEYIMRKAGLDESQAGIKIAGRNINNLRYADDTTLMAESEEELKNLLMRVKEESAKYGLKLNIKKTKIMATGPITSWQIEGEEMEAVRDFTFLGSMITADGDSSHEIKRRLLLGRRAMTGLDSILRSRDVTLPTKVRIVKAMVFPVVMYGSESWTIKKADRRRIDAFELWCWRRLLRVPWTARRSNASILKEISPECSLEGQIVKLRLQYFGHLMRREDSLEKTLMLGKMEGTRRRGRQRTRWLDSVFEVTSMSLTKLREVVEDRGAWRALVHGVTKSRTRLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8G5</accession>
    <name>A0A670J8G5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">THO complex subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J8G5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021794.1">
        <property type="protein sequence ID" value="ENSPMRP00000020516.1"/>
        <property type="gene ID" value="ENSPMRG00000013351.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002873"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28444" checksum="32CEEBF2827C9150" modified="2020-06-17" version="1">MCGCSCAGEDLHLSALHLAIMPPPPGREALGSRDLAFREIRNWDFFCVDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSHEEGYTQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKDIENNIAAAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKQLEALGKELQHLSHIKENVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEAEDASDTPMVSADKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8I7</accession>
    <name>A0A670J8I7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J8I7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020773.1">
        <property type="protein sequence ID" value="ENSPMRP00000019557.1"/>
        <property type="gene ID" value="ENSPMRG00000012766.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000187690"/>
    <dbReference type="OMA" id="DYRCDIE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030277">
        <property type="term" value="P:maintenance of gastrointestinal epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000813">
        <property type="term" value="P:negative regulation of barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052853">
        <property type="entry name" value="Actin_dynamics_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47574">
        <property type="entry name" value="CANCER-RELATED REGULATOR OF ACTIN DYNAMICS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47574:SF3">
        <property type="entry name" value="CAPPING PROTEIN-INHIBITING REGULATOR OF ACTIN DYNAMICS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="61" mass="7213" checksum="530DC1C3EBA53925" modified="2020-06-17" version="1">MGTRAFSHESIFIPDGRTESEESLQAMSQENILGKVKTLQVRIRKRHDYRCDIERELTEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8L4</accession>
    <name>A0A670J8L4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-binding cassette sub-family E member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNase L inhibitor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ribonuclease 4 inhibitor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ABCE1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>CTP + H2O = CDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>UTP + H2O = UDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with PINK1. Interacts with CNOT4. Interacts with PELO. Probably heterodimerizes with RNASEL; this interaction inhibits RNASEL.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. ABCE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J8L4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021835.1">
        <property type="protein sequence ID" value="ENSPMRP00000020555.1"/>
        <property type="gene ID" value="ENSPMRG00000013362.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015089"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043273">
        <property type="term" value="F:CTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060698">
        <property type="term" value="F:endoribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140708">
        <property type="term" value="P:CAT tailing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK13409.1"/>
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        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABCEFAMILY"/>
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        <property type="entry name" value="AAA"/>
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        <property type="entry name" value="4Fe-4S ferredoxins"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <location>
            <begin position="46"/>
            <end position="75"/>
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            <begin position="79"/>
            <end position="315"/>
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    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="342"/>
            <end position="562"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051233"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052409"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="634" mass="71428" checksum="BD1EE8E691C5AC96" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAC6</accession>
    <name>A0A670JAC6_PODMU</name>
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        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114583365</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JAC6"/>
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        <property type="protein sequence ID" value="ENSPMRP00000020152.1"/>
        <property type="gene ID" value="ENSPMRG00000013132.1"/>
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    <dbReference type="OMA" id="FICEMAM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="7tmA_OR2_unk"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="41"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="312" mass="34616" checksum="1986D13A09BC66E7" modified="2020-06-17" version="1">MGEENVTFVKEFILVGFSSDRRTQILLFVVVLIIYSLTIVGNLLIIMLVWVESSLHIPMYFFLSNLAGLEICYVTTTLPQTMASLVSGNGAISFTRCMAQMYITLSLGSCECLLLGVMAYDRYLAICHPLIYTSVMGWWRQFLLASVTWVGGFLLGSLMVGSATSLYFCGLNRIDHFICEMAMVIKLSCTDTYITEAAIFLAASLGVLLPLSIIMTSYGFVISSVLKMRSTAGWRKAFSTCGSHLIVVTLFYGTVISMYLIPRSASDRDKKIAVFYIVVTPLLNPIIYTLRNKDIHGATAKALRRLAILKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAE5</accession>
    <name>A0A670JAE5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="11">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HCCS</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:22650"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A670JAE5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022789.1">
        <property type="protein sequence ID" value="ENSPMRP00000021473.1"/>
        <property type="gene ID" value="ENSPMRG00000013937.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004175"/>
    <dbReference type="OMA" id="KARFWLF"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="267" mass="30981" checksum="F69569BBAE2B6E32" modified="2020-06-17" version="1">MGLSASSPSIALQANVSEQPPAVPSQCPMHQKNMEGCPMNMQSAGSLSENQSYPVPAHQERAYEYVECPVKSQMHEKIDPSNMMPAPNQLPAPDQPFPLSTVREESTIPRASSEQKWVYPSEQMFWNAMLRKGWRWKDDDIKPEDMNNIIKIHNQNNEQAWKEILKWEALHARECPCGPALIRFGGKAKEYSPRARIRSWMGYELPFDRHDWIVDRCGKEVRYVIDYYDGGEVDKNYQFTILDVRPAFDSLTAVWDRMKVAWWRWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC13</accession>
    <name>A0A670JC13_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JC13"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023357.1">
        <property type="protein sequence ID" value="ENSPMRP00000021988.1"/>
        <property type="gene ID" value="ENSPMRG00000014298.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="OMA" id="NCEECNM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002565">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004135">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001621">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000806">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002597">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000588">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000990">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="689" mass="79826" checksum="B9A50A406699A754" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC46</accession>
    <name>A0A670JC46_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
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            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
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        <property type="gene ID" value="ENSPMRG00000014143.1"/>
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    <dbReference type="Ensembl" id="ENSPMRT00000023140.1">
        <property type="protein sequence ID" value="ENSPMRP00000021805.1"/>
        <property type="gene ID" value="ENSPMRG00000014143.1"/>
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        <property type="component" value="Chromosome 15"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="STKc_GRK4_like"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
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        <property type="entry name" value="GPCR_kinase"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF26">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
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        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="14">
        <location>
            <begin position="59"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="186"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="449"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000308"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="587" mass="67248" checksum="0062E986B32EA57C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JD81</accession>
    <name>A0A670JD81_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Beta-hexosaminidase</fullName>
            <ecNumber evidence="19">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">HEXA</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-beta-D-6-sulfogalactosaminyl-(1-&gt;4)-alpha-L-iduronyl-(1-&gt;3)-N-acetyl-D-6-sulfogalactosamine + H2O = alpha-L-iduronyl-(1-&gt;3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine</text>
            <dbReference type="Rhea" id="RHEA:64384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:152567"/>
            <dbReference type="ChEBI" id="CHEBI:152568"/>
            <dbReference type="ChEBI" id="CHEBI:153064"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:64385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide + H2O = a beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide + N-acetyl-beta-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:48276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28497"/>
            <dbReference type="ChEBI" id="CHEBI:90163"/>
            <dbReference type="ChEBI" id="CHEBI:90164"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:48277"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:47940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28497"/>
            <dbReference type="ChEBI" id="CHEBI:60065"/>
            <dbReference type="ChEBI" id="CHEBI:71502"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:47941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:47968"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28497"/>
            <dbReference type="ChEBI" id="CHEBI:79210"/>
            <dbReference type="ChEBI" id="CHEBI:79218"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-D-GalNAc-(1-&gt;4)-alpha-L-IdoA-(1-&gt;3)-beta-D-GalNAc-4-sulfate-(1-&gt;4)-alpha-L-IdoA-(1-&gt;3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1-&gt;3)-beta-D-GalNAc-4-sulfate-(1-&gt;4)-alpha-L-IdoA-(1-&gt;3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:64372"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28037"/>
            <dbReference type="ChEBI" id="CHEBI:152565"/>
            <dbReference type="ChEBI" id="CHEBI:152566"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:64373"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">There are 3 beta-hexosaminidase isozymes: isozyme A (hexosaminidase A) is a heterodimer composed of one subunit alpha and one subunit beta (chain A and B); isozyme B (hexosaminidase B) is a homodimer of two beta subunits (two chains A and B); isozyme S (hexosaminidase S) is a homodimer of two alpha subunits. The composition of the dimer (isozyme A versus isozyme S) has a significant effect on the substrate specificity of the alpha subunit active site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="19"/>
    <dbReference type="RefSeq" id="XP_028562209.1">
        <property type="nucleotide sequence ID" value="XM_028706376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JD81"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022897.1">
        <property type="protein sequence ID" value="ENSPMRP00000021579.1"/>
        <property type="gene ID" value="ENSPMRG00000014002.1"/>
    </dbReference>
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    <sequence length="522" mass="58750" checksum="20DA00A3689EE184" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEH1</accession>
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        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Odorant receptor.</text>
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        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
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    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
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        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="231"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="258" mass="29178" checksum="FFDB1E33833645DD" modified="2020-06-17" version="1">MYFFLMNLALQDLGSVSVIMPKSMANTILNTRYISNLGCVAQVLFFLFFIASDFFLLTVMAYDRYIAICKPLQYEMLMNRQACTQMIISVWVISFFYGVLHTGGTFAPPFCSNLVNQFFCEVPELLKLTCSDLYLLEIGVLAFSLVIALGCFIFIVVTYVYIFSSVLKIPSSAGRQKAFSTCLPHLIVCSLFVFTGYFAYLKPIFNSPPYLDLAFTVIYSMVPPLMNPVIYSMRNKEIKNALSKLLGLRHSSMNTFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JGQ8</accession>
    <name>A0A670JGQ8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trypsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114603576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598527.1">
        <property type="nucleotide sequence ID" value="XM_028742694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JGQ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024686.1">
        <property type="protein sequence ID" value="ENSPMRP00000023245.1"/>
        <property type="gene ID" value="ENSPMRG00000015100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603576"/>
    <dbReference type="KEGG" id="pmua:114603576"/>
    <dbReference type="GeneTree" id="ENSGT01050000244971"/>
    <dbReference type="OMA" id="KFIHPAY"/>
    <dbReference type="OrthoDB" id="10012881at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035821">
        <property type="term" value="P:modulation of process of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF47">
        <property type="entry name" value="KALLIKREIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025559554" evidence="7">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="33"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="271" mass="29489" checksum="45D3D836A7B972E4" modified="2020-06-17" version="1">MQVASTPCRAMRLLAMVVLLLTLTASAQDESRIIGGQDCALGEQRYQVVLSNSKRNGPDILCGGVLIDKYWVLTAAHCNQQGVIHTRMGDHSLRANEGSEQCITSAQKFPHPNYNPTTHDSDIMLIRLSNPAFINEYVRPIQLATQCVQPNTRCQVSGWGTTTTPQSQFPDILQCAQVYTISNEECNQAYPNGITENMLCAGVSRGGVDSCQGDSGGPLVCNGKLEGIVSWGMQICAQSGKPGVYTKICRFTDWIQSVIRNNSVNRAADTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHD2</accession>
    <name>A0A670JHD2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein phosphatase 1 regulatory subunit 13 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PPP1R13L</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JHD2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024462.1">
        <property type="protein sequence ID" value="ENSPMRP00000023029.1"/>
        <property type="gene ID" value="ENSPMRG00000014946.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160551"/>
    <dbReference type="OMA" id="QPNQYKH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060048">
        <property type="term" value="P:cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003215">
        <property type="term" value="P:cardiac right ventricle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031076">
        <property type="term" value="P:embryonic camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048871">
        <property type="term" value="P:multicellular organismal-level homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003229">
        <property type="term" value="P:ventricular cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000008">
        <property type="entry name" value="Apoptosis-stimulating of p53 protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028320">
        <property type="entry name" value="iASPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24164">
        <property type="entry name" value="RELA-ASSOCIATED INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24164:SF4">
        <property type="entry name" value="RELA-ASSOCIATED INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="957" mass="105476" checksum="F9E4C221F9141921" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Bellati A."/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
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            <fullName evidence="5">Transglutaminase-like domain-containing protein</fullName>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:54816"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:14005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:138370"/>
            <dbReference type="EC" id="2.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="4">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JLZ5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027652.1">
        <property type="protein sequence ID" value="ENSPMRP00000026058.1"/>
        <property type="gene ID" value="ENSPMRG00000016855.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244939"/>
    <dbReference type="OMA" id="GSWTINL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000002">
        <property type="entry name" value="Erythrocyte membrane protein band 4.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001640">
        <property type="entry name" value="Prostate-specific transglutaminase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001406">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001482">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF70">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="5">
        <location>
            <begin position="262"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="703" mass="78345" checksum="443C6FEBA7C3309E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JMK5</accession>
    <name>A0A670JMK5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Amyloid protein-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Amyloid beta precursor protein-binding protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">APPBP2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter APPBP2. Interacts with APP; APP interaction inhibits the E3 ubiquitin-protein ligase activity of the CRL2(APPBP2) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028564783.1">
        <property type="nucleotide sequence ID" value="XM_028708950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JMK5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027235.1">
        <property type="protein sequence ID" value="ENSPMRP00000025656.1"/>
        <property type="gene ID" value="ENSPMRG00000016620.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585995"/>
    <dbReference type="KEGG" id="pmua:114585995"/>
    <dbReference type="CTD" id="10513"/>
    <dbReference type="GeneTree" id="ENSGT00390000010722"/>
    <dbReference type="OMA" id="YAESSHC"/>
    <dbReference type="OrthoDB" id="7103806at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000177">
        <property type="entry name" value="Amyloid beta precursor protein binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000152">
        <property type="entry name" value="Amyloid protein-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042476">
        <property type="entry name" value="APPBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575:SF1">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 19" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="19">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="586" mass="66985" checksum="AC89E5E8905FC948" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNT0</accession>
    <name>A0A670JNT0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stanniocalcin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">STC1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the stanniocalcin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028564317.1">
        <property type="nucleotide sequence ID" value="XM_028708484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JNT0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028341.1">
        <property type="protein sequence ID" value="ENSPMRP00000026713.1"/>
        <property type="gene ID" value="ENSPMRG00000017272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585647"/>
    <dbReference type="KEGG" id="pmua:114585647"/>
    <dbReference type="CTD" id="6781"/>
    <dbReference type="GeneTree" id="ENSGT00390000005989"/>
    <dbReference type="OMA" id="MCSIAKR"/>
    <dbReference type="OrthoDB" id="10025265at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035988">
        <property type="term" value="P:chondrocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001886">
        <property type="term" value="P:endothelial cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003421">
        <property type="term" value="P:growth plate cartilage axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051926">
        <property type="term" value="P:negative regulation of calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010596">
        <property type="term" value="P:negative regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903403">
        <property type="term" value="P:negative regulation of renal phosphate excretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090280">
        <property type="term" value="P:positive regulation of calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086004">
        <property type="term" value="P:regulation of cardiac muscle cell contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044070">
        <property type="term" value="P:regulation of monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004978">
        <property type="entry name" value="Stanniocalcin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245">
        <property type="entry name" value="STANNIOCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245:SF1">
        <property type="entry name" value="STANNIOCALCIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03298">
        <property type="entry name" value="Stanniocalcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025337388" evidence="5">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="247" mass="27492" checksum="1C426565942A5EDA" modified="2020-06-17" version="1">MLRKSAVLLLLAAAAAATYEVEQNDSFSPRKARLAAQNSADVVRCLNSALQVGCGAFACLENSTCDTGGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGITSKVFLAIRRCSTFQRMISEVQEECYSKLDICGIAKKNPEAITEVVQLPNHFSNRYYNKLVRSLLECDEETVATIKDSLMAKIGPNMASLFHLLQTDHCAQIHPRADFSRRRITEPQKLKIYFRNLRGEGPVQSHMKRSSSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPG0</accession>
    <name>A0A670JPG0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial assembly of ribosomal large subunit protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MALSU1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028606331.1">
        <property type="nucleotide sequence ID" value="XM_028750498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JPG0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028590.1">
        <property type="protein sequence ID" value="ENSPMRP00000026948.1"/>
        <property type="gene ID" value="ENSPMRG00000017403.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607362"/>
    <dbReference type="KEGG" id="pmua:114607362"/>
    <dbReference type="CTD" id="115416"/>
    <dbReference type="GeneTree" id="ENSGT00390000015035"/>
    <dbReference type="OMA" id="KDICVIN"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140978">
        <property type="term" value="F:mitochondrial large ribosomal subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070130">
        <property type="term" value="P:negative regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000018">
        <property type="entry name" value="Mitochondrial assembly of ribosomal large subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="229" mass="25598" checksum="E36B59438E5D41A5" modified="2020-06-17" version="1">MWRSSRCLRALLRLRPWQAAGRGGSSGLCEAAAAAPRVLSRAGSLGLRRFSAAGSSELRDAEVEQGLQDDGAAGQEQRIRSGAGEAAGASDHVSSVFSIDYMVSLLRQENAKDICVIELPPELKYSHYFIIVSGTSPRHLHAMAQYLVKMYKHLRTDWDPHVVIEGKDSEDWICIDFGNIVIHFMLPETREIYELEKLWTLRSYDDQLAQILPESLPDDFIIGLTPEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPL7</accession>
    <name>A0A670JPL7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JPL7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026437.1">
        <property type="protein sequence ID" value="ENSPMRP00000024917.1"/>
        <property type="gene ID" value="ENSPMRG00000016105.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163677"/>
    <dbReference type="OMA" id="WHLFSGS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33426">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33426:SF45">
        <property type="entry name" value="IMMUNODEFICIENCY LENTIVIRAL MATRIX N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="373" mass="37770" checksum="1E8A7F4F454A243C" modified="2020-06-17" version="1">MRPLAKGAPTIWAVEGAFACVDSAVLQKVRTDAEGLPAVLTLEGLFSGVDPLVTQQGGAEAKGLAAVHALIRLLPGVGDMVLDQSGAERKGLAAFLAPERALPGVGPLVLGEGGALGKRLAAGAAGEGALPGVHPSVVQQVGVAVEALAAIGAFVRFLSRVDDLVLDEGGAEGKGLPAGAAVVGLLPRVDPLVLNEVGAPAEAPAAIGAFVRLLARVCPLVLEEGRAPGEAFAAGAALVGLLSAVDAAVLAQDGAGAKAFPTFGAPVWFVRHRRGNGRGGREGRFAVDVPLTGANVEVSATIAGIQAENTVLSIVRIINKVLSGISICFSLHLWKDTSGSFHIRVESLTRASTHVLVNVTVHVGRQILGTLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPM8</accession>
    <name>A0A670JPM8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box only protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114602814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028597322.1">
        <property type="nucleotide sequence ID" value="XM_028741489.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028597323.1">
        <property type="nucleotide sequence ID" value="XM_028741490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JPM8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026447.1">
        <property type="protein sequence ID" value="ENSPMRP00000024927.1"/>
        <property type="gene ID" value="ENSPMRG00000016109.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602814"/>
    <dbReference type="KEGG" id="pmua:114602814"/>
    <dbReference type="GeneTree" id="ENSGT00940000159408"/>
    <dbReference type="OMA" id="HIFFQHG"/>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22168">
        <property type="entry name" value="F-box_FBXO6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000002">
        <property type="entry name" value="F-box only protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF12">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="3">
        <location>
            <begin position="69"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="254" mass="29669" checksum="C9AD95394DA3644F" modified="2020-06-17" version="1">MVNIGDLPEDILIDVLCLVPARELVLRCRLVCLLWRNLVDLPSLWKRKCHLEGFHPRAPDRNVPDWRIFYFLSTLRKNLIQNPCAEAGFNSWKIEQNGGDEWKIEDLPGNHGREFPDPHVCKYFVTSYGLCLKNQLVTLKNHGYWDELMDEVKPAIVVKDWYAARYDCGCRYQLRVELLSADYIVLQEFHPEDVVIEPWSDATWHKVSHTFHDYPRGVRHVILHHGGSDTQYWAGWYGIRVTNSSITIEPEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSK2</accession>
    <name>A0A670JSK2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the avidin/streptavidin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JSK2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027513.1">
        <property type="protein sequence ID" value="ENSPMRP00000025922.1"/>
        <property type="gene ID" value="ENSPMRG00000016785.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001847"/>
    <dbReference type="OMA" id="TYYLCAL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.30">
        <property type="entry name" value="Avidin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005469">
        <property type="entry name" value="Avidin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036896">
        <property type="entry name" value="Avidin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005468">
        <property type="entry name" value="Avidin/str"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051764">
        <property type="entry name" value="Avidin/Streptavidin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34399:SF3">
        <property type="entry name" value="AVID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34399">
        <property type="entry name" value="AVIDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01382">
        <property type="entry name" value="Avidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00709">
        <property type="entry name" value="AVIDIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50876">
        <property type="entry name" value="Avidin/streptavidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51326">
        <property type="entry name" value="AVIDIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025428679" description="Lipocalin/cytosolic fatty-acid binding domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14368" checksum="FAAF30A6F8AAD7FF" modified="2020-06-17" version="1">GFPEVPPPLTLLFPSLALLLGSKMVLNPPDDSGQFTGSYLTAVSAAQKPIRVSPLVGAQHDPKGAEEEYTFGFLVNWSFSDSIAAFAGQRFVDDKGKETLETTWLLRQKVESHGDDWEATRVGRNVFTREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTG1</accession>
    <name>A0A670JTG1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ITPR interacting domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ITPRID1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        </source>
    </evidence>
    <sequence length="575" mass="63176" checksum="40AAAE20E3C1C7CE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUL1</accession>
    <name>A0A670JUL1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A670JUL1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029866.1">
        <property type="protein sequence ID" value="ENSPMRP00000028151.1"/>
        <property type="gene ID" value="ENSPMRG00000018175.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012914"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="110" mass="12223" checksum="F540AFC9D191EBFB" modified="2020-06-17" version="1">MAAVLAEESAGGAESEAAAVPPMAGLEMVQQGAEARVYRGLFLGRPTVAKHRFPKRYRHPLLEERLSRRRTAQEARSLLRCRRAGGRASRLDSTMTVLKVWMKLDTSTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JV60</accession>
    <name>A0A670JV60_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA helicase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HELB</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028602250.1">
        <property type="nucleotide sequence ID" value="XM_028746417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JV60"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028954.1">
        <property type="protein sequence ID" value="ENSPMRP00000027294.1"/>
        <property type="gene ID" value="ENSPMRG00000017610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605307"/>
    <dbReference type="KEGG" id="pmua:114605307"/>
    <dbReference type="CTD" id="92797"/>
    <dbReference type="GeneTree" id="ENSGT00390000006913"/>
    <dbReference type="OMA" id="KIKHAWA"/>
    <dbReference type="OrthoDB" id="416437at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903775">
        <property type="term" value="P:regulation of DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17933">
        <property type="entry name" value="DEXSc_RecD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058839">
        <property type="entry name" value="WHD_HELB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF6">
        <property type="entry name" value="DNA HELICASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13604">
        <property type="entry name" value="AAA_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25894">
        <property type="entry name" value="WHD_HELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase B winged helix" evidence="4">
        <location>
            <begin position="249"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1053" mass="120007" checksum="23D976A6547A1C67" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVT2</accession>
    <name>A0A670JVT2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JVT2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031147.1">
        <property type="protein sequence ID" value="ENSPMRP00000029368.1"/>
        <property type="gene ID" value="ENSPMRG00000018986.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018141"/>
    <dbReference type="OMA" id="FIMTTHA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF85">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="356" mass="40674" checksum="C6AE1D0D0477ED5B" modified="2020-06-17" version="1">MDKDNRHIKDMTLEDEPLRSEGVQHATEEERRTSTSRLRADEVAGPKPEGRSVADMPGSERKIQCCKEKYCIGTWNVRTMNLGKLDVVKNEMARINIDILGISELKWTGMGEFSSDDHHIYYCGQESRKRNGVALIVNKRVAKAVLGCNLKNDRMISIRIQGRPFNITVIQVYAPTTGAEETEIDQFYEHLQHLIEMTPKKDVLLIIGDWNAKVGSQEIKGTTGKFGLGVQNEAGQRLIEFCQENKLVITNTLFQQHKRRLYTWTSPDGQHRNQIDYILCSQRWRSSIQSAKTRPGADSGSDHQLLIAKFKLKLKKAGKTTGPVRYNLSQIPYEYAVEVRNRFKDLDLVDRVPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVZ5</accession>
    <name>A0A670JVZ5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JVZ5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030372.1">
        <property type="protein sequence ID" value="ENSPMRP00000028631.1"/>
        <property type="gene ID" value="ENSPMRG00000018505.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000192389"/>
    <dbReference type="OMA" id="YSTGQDN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050413">
        <property type="entry name" value="TCR_beta_variable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23268:SF28">
        <property type="entry name" value="T CELL RECEPTOR BETA VARIABLE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23268">
        <property type="entry name" value="T-CELL RECEPTOR BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="126" mass="14117" checksum="A54E2ECD6F0FF953" modified="2020-06-17" version="1">LGTKICRAQMDLGDPYSQDMVVKKGDNVTLDCSQKNSNYINMYWYKQERKMHHLQLIGFSIHGNDPEMEMTQYSIDRPEVTRASLSIPQGQAADTAVYFCAASKGTVRVLCLPAAHEHRSSAHAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWH5</accession>
    <name>A0A670JWH5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GOT1L1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670JWH5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030552.1">
        <property type="protein sequence ID" value="ENSPMRP00000028801.1"/>
        <property type="gene ID" value="ENSPMRG00000018613.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183082"/>
    <dbReference type="OMA" id="MSMIKSK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF6">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="48"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="413" mass="46140" checksum="F017E21AEBA36BD2" modified="2020-06-17" version="1">RRYFLKYATPHTPPLTSALPFFAGCQTDLEEVWIPPVVKRILLQIPEDPTLNHEYLPQLGILGFTRAAMELAIGKDSHALLDNRACGVQTNGGTGALWIGAEFLHHWYKPSYCTAPATVLIAAPHLDNLGCIFQVAGFSDIRSYHYWDPIKLTVDTEGFLEELQDAPEGSIVFLHAPEETGLTPKQWEEVAAVMEKKHLFPFFDIAAQGLASGNLDKDAWAVRHFVAKGFELLCAQSFSKMFGLYEERVGNLIVVTKNNQTLIRIQSQLSKQICMTWFSPTSLGARVIAMVLTSPALLYECLLKLVKRIMLIREKLKEKLRILGTPGSWEHITAQSGVNSFVGLLPSQVDFLAQHKHIYLLANKQINICSINSKNLDYVAQSIHEAIVTTIPQIQSELMESSSDSHEPSREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXQ0</accession>
    <name>A0A670JXQ0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Chloride voltage-gated channel 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CLCN1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JXQ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031009.1">
        <property type="protein sequence ID" value="ENSPMRP00000029236.1"/>
        <property type="gene ID" value="ENSPMRG00000018896.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="ClC_1_like"/>
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        <property type="entry name" value="CBS_dom_sf"/>
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        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage_CLC"/>
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    </dbReference>
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        <property type="entry name" value="CLCHANNEL"/>
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    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0869">Chloride channel</keyword>
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    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="79"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="227"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="263"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="350"/>
            <end position="371"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="830"/>
            <end position="852"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="867"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="935"/>
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        </location>
    </feature>
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            <begin position="27"/>
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        </location>
    </feature>
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        <location>
            <begin position="692"/>
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        </location>
    </feature>
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    </feature>
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    </feature>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029236.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZ16</accession>
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            <fullName evidence="5">hyaluronoglucosaminidase</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
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        </reaction>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:hyaluronan catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of release of sequestered calcium ion into cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:sensory perception of sound"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="PANDER_like_TMEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CEMIP/CEMIP2"/>
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    <keyword evidence="9 15" id="KW-0430">Lectin</keyword>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="23"/>
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        <location>
            <begin position="33"/>
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    <sequence length="1351" mass="151746" checksum="A09C66919924FACF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZJ2</accession>
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        </submittedName>
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        <name evidence="5" type="primary">LOC114587164</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K015</accession>
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        <location>
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        </location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="236" mass="27338" checksum="CD8182E62328E09B" modified="2020-06-17" version="1">MADEQEIMCKLESIKEIRNKTLQMEKIKARLKAEFEALESEERHLKEYKQEMDLLLQEKMAHVEELRLIHADINVMENTIKQSENDLNKLLESTRRLHEEYKPLKEHVDALRMTLGLQRLPDLCEEEEKLSLELACHAISRSIGMHQSALSAKPKAALGIQRSPRGSKTNESLPRKKLLRGNGATVCDMLVIPPFGLLRTSRTCTTLRLKNTWYRENKGFYPISDNMLNVLEKQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0B6</accession>
    <name>A0A670K0B6_PODMU</name>
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        <recommendedName>
            <fullName evidence="13">Cytochrome P450 1A</fullName>
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        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Microsome membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028600143.1">
        <property type="nucleotide sequence ID" value="XM_028744310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K0B6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030149.1">
        <property type="protein sequence ID" value="ENSPMRP00000028422.1"/>
        <property type="gene ID" value="ENSPMRG00000018348.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604295"/>
    <dbReference type="KEGG" id="pmua:114604295"/>
    <dbReference type="GeneTree" id="ENSGT00950000183037"/>
    <dbReference type="OMA" id="DPRAYWQ"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20676">
        <property type="entry name" value="CYP1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000002">
        <property type="entry name" value="Cytochrome P450 1A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008066">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF21">
        <property type="entry name" value="CYTOCHROME P450 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01683">
        <property type="entry name" value="EP450ICYP1A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0492">Microsome</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="517" mass="58654" checksum="9C8956A6F9EE03A2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0R3</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K0R3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031568.1">
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    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286962"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="301"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="767" mass="85280" checksum="96C9002AEEC1CA80" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2F3</accession>
    <name>A0A670K2F3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat and LEM domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ANKLE1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSPMRT00000032148.1">
        <property type="protein sequence ID" value="ENSPMRP00000030320.1"/>
        <property type="gene ID" value="ENSPMRG00000019597.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000049316"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045950">
        <property type="term" value="P:negative regulation of mitotic recombination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905456">
        <property type="term" value="P:regulation of lymphoid progenitor cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905453">
        <property type="term" value="P:regulation of myeloid progenitor cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10454">
        <property type="entry name" value="GIY-YIG_COG3680_Meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034998">
        <property type="entry name" value="ANKLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22945">
        <property type="entry name" value="LEM-3_GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="544" mass="59258" checksum="302C295E7A18645F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2R3</accession>
    <name>A0A670K2R3_PODMU</name>
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        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K2R3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033727.1">
        <property type="protein sequence ID" value="ENSPMRP00000031798.1"/>
        <property type="gene ID" value="ENSPMRG00000020593.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234536"/>
    <dbReference type="OMA" id="CICYNGD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002426">
        <property type="entry name" value="Immunoglobulin heavy variable V15-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="111" mass="12106" checksum="2282DB2256D15D70" modified="2020-06-17" version="1">DVQLVSSGPGTVRPGENLRLLCKVTGVSITDSNSVWNWIRQPSGKVLEWIARIYSHDGGKWFAASLQSRVTISSDNSKNEFSLQLNSLTAADTAVYFCTELFHQAFGQGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5B1</accession>
    <name>A0A670K5B1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="8">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GLDC</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A670K5B1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033954.1">
        <property type="protein sequence ID" value="ENSPMRP00000032016.1"/>
        <property type="gene ID" value="ENSPMRG00000020751.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017970"/>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000025">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000153">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001696">
        <property type="entry name" value="PRK00451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="11">
        <location>
            <begin position="111"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="10">
        <location>
            <begin position="632"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="875"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1066" mass="118307" checksum="14E21DCF2E91143D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K749</accession>
    <name>A0A670K749_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114588401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028569504.1">
        <property type="nucleotide sequence ID" value="XM_028713671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K749"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035414.1">
        <property type="protein sequence ID" value="ENSPMRP00000033383.1"/>
        <property type="gene ID" value="ENSPMRG00000021644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588401"/>
    <dbReference type="KEGG" id="pmua:114588401"/>
    <dbReference type="GeneTree" id="ENSGT00940000157023"/>
    <dbReference type="OMA" id="WLTVNVW"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025715715" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="566"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="566" mass="62508" checksum="056EABCB973BF98D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7M5</accession>
    <name>A0A670K7M5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Blue-sensitive opsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114587876</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028568556.1">
        <property type="nucleotide sequence ID" value="XM_028712723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K7M5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035618.1">
        <property type="protein sequence ID" value="ENSPMRP00000033573.1"/>
        <property type="gene ID" value="ENSPMRG00000021757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587876"/>
    <dbReference type="KEGG" id="pmua:114587876"/>
    <dbReference type="GeneTree" id="ENSGT01030000234549"/>
    <dbReference type="OMA" id="LTIACTM"/>
    <dbReference type="OrthoDB" id="8545112at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15077">
        <property type="entry name" value="7tmA_SWS2_opsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000018">
        <property type="entry name" value="Rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001521">
        <property type="entry name" value="Opsin_blue"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00574">
        <property type="entry name" value="OPSINBLUE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="2 16" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4 16" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="63"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="338"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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    <sequence length="363" mass="40254" checksum="F95FD3872270CE85" modified="2020-06-17" version="1">MHKARSDSQDDLPENFFIPVPLDVANITTLSPFLVPQTHLGSPGLFMSMAAFMFLLVVLGVPINILTIFCTFKYKKLRSHLNYILVNLAVSNLVVVCIGSTTAFYSFSHMYFIMGPLACKIEGFAATLGGMVSLWSLAVVAFERYLVICKPLGNFTFRGTHAIVGCMITWVFGLVASVPPLFGWSRYIPEGLQCSCGPDWYTTNNKWNNESYVLFLFSFCFGVPLSVIVFSYGRLLLTLRAVAKQQEQSATTQKAEREVTKMVVVMVMGFLVCWLPYASFALWVVTHRGEPFDVRLASIPSVFSKASSVYNPVIYVFMNKQFRSCMLKLVFCGKSPFGEEEDVSGSSQATQVSSVSSSQVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7X8</accession>
    <name>A0A670K7X8_PODMU</name>
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        <submittedName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPCS</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
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            <taxon>Episquamata</taxon>
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            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7X8"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="134" mass="15228" checksum="5F66FFC1DDCAFFAB" modified="2020-06-17" version="1">MFYLAAAVSDFYIPASEMPEHKIQSTDGPLQITMKMVPKMLSPLVKEWAPEAFVISFKLETNPSILIDKAKQALEKYRHQVVVANVLDSRRTSVIVVTKDLETQLLLSDDEVAQGMEIEEKIVSYLESQHRAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8T4</accession>
    <name>A0A670K8T4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein family A (Hsp70) member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HSPA8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028564281.1">
        <property type="nucleotide sequence ID" value="XM_028708448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K8T4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035210.1">
        <property type="protein sequence ID" value="ENSPMRP00000033191.1"/>
        <property type="gene ID" value="ENSPMRG00000021522.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585620"/>
    <dbReference type="KEGG" id="pmua:114585620"/>
    <dbReference type="CTD" id="3312"/>
    <dbReference type="GeneTree" id="ENSGT00950000183206"/>
    <dbReference type="OMA" id="AYTKNQD"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098690">
        <property type="term" value="C:glycinergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098684">
        <property type="term" value="C:photoreceptor ribbon synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140545">
        <property type="term" value="F:ATP-dependent protein disaggregase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055131">
        <property type="term" value="F:C3HC4-type RING finger domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044829">
        <property type="term" value="P:host-mediated activation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061738">
        <property type="term" value="P:late endosomal microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900226">
        <property type="term" value="P:negative regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902904">
        <property type="term" value="P:negative regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160020">
        <property type="term" value="P:positive regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061740">
        <property type="term" value="P:protein targeting to lysosome involved in chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000135">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000003">
        <property type="entry name" value="heat shock cognate 71 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="614"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="646" mass="70861" checksum="8155195A9AD59D8B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KA93</accession>
    <name>A0A670KA93_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">cAMP responsive element binding protein 3 like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CREB3L3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028569755.1">
        <property type="nucleotide sequence ID" value="XM_028713922.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028569757.1">
        <property type="nucleotide sequence ID" value="XM_028713924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KA93"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035757.1">
        <property type="protein sequence ID" value="ENSPMRP00000033706.1"/>
        <property type="gene ID" value="ENSPMRG00000021853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588541"/>
    <dbReference type="KEGG" id="pmua:114588541"/>
    <dbReference type="CTD" id="84699"/>
    <dbReference type="GeneTree" id="ENSGT00940000159261"/>
    <dbReference type="OMA" id="DSHFFGT"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14689">
        <property type="entry name" value="bZIP_CREB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000042">
        <property type="entry name" value="Cyclic AMP-responsive element-binding protein 3-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051381">
        <property type="entry name" value="CREB_ATF_subfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996">
        <property type="entry name" value="AGAP001464-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996:SF1">
        <property type="entry name" value="CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BZIP" evidence="16">
        <location>
            <begin position="230"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="465" mass="51183" checksum="1CEA446702D67D8E" modified="2020-06-17" version="1">MTATSLDSMELLDLLFDRQDGVLRSVEIGSTATAWMGLEDSRLLKAQENEDFINSILGAPDAALDSPSWSPAASDSGISEDPSSDQLDSPPHYMPTGSPGAYSDGGSHSDLAYPVYQDSCRVLPVLKGPGAELREAEVSIDFNMWEAGFYPEERQEQAAPQLNSCTLTIKDLLLSNSCEMHQQGMNPSLLRQTPGTCQELVLTEDEKKLLAKEGVTLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLESRMSACTAQNQELQRKVVHLEKQNLSLLQQLKKLQGLVMQSSGKAAQTSTCVAVLLLSFALIVFPSIRPFTRNKAELEGDFVPVRVFSRSLNNDASSRVAYPMAKEADQSSKEPEKTLWTQYAHKGHTEQDGTLKNLVVRHHVLSRHHDAGEAVVSNGTEPLHEVAYSHLEGLEGPGEHVGHSLAATAWAESGQPSKGVLEQANEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KB16</accession>
    <name>A0A670KB16_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KB16"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036057.1">
        <property type="protein sequence ID" value="ENSPMRP00000033996.1"/>
        <property type="gene ID" value="ENSPMRG00000022046.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001808">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000116">
        <property type="entry name" value="Zinc finger protein 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000540">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001437">
        <property type="entry name" value="Zinc finger protein 594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000862">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="749"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="780" mass="90617" checksum="C871D6C9F823DD87" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KB66</accession>
    <name>A0A670KB66_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">17-beta-hydroxysteroid dehydrogenase type 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114592988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KB66"/>
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        <property type="gene ID" value="ENSPMRG00000022504.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154118"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Retinol dehydrogenase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF4">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025674524" evidence="4">
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            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="315" mass="34990" checksum="5467584915FBC213" modified="2020-06-17" version="1">MWLYLAALLGLYFLRRWYQERQKVENLTEKFVFITGCDSGFGNLLARQLDARGLRVLAACLTQKGAEQLDKVTSERLKTSILDVTSKESVAAATEWVKGCIGSKGLWGFVNNAGMGIPTGPNEWLTKDDFAKVINVNLLGMIDVTLHMVPLVRRARGRVVNVCSTMGRLACFGGGYCPSKFGAEAFSDTLRRELHPFGVQVSIIEPGGFKTPIVSNALENFQTVWSQVPSDIRDCYGQQYFEQCCKSFQQLLDGCSDKLHLVTDCIEHALTSCSPRTRYSPGWDAKLFYLPVSYLPTTIADYVLTRSGPKPAQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCL8</accession>
    <name>A0A670KCL8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TTBK1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.</text>
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    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034539.1">
        <property type="protein sequence ID" value="ENSPMRP00000032572.1"/>
        <property type="gene ID" value="ENSPMRG00000020984.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160981"/>
    <dbReference type="OMA" id="KERWNKR"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
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        <property type="term" value="C:neuronal cell body"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048156">
        <property type="term" value="F:tau protein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007611">
        <property type="term" value="P:learning or memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0061890">
        <property type="term" value="P:positive regulation of astrocyte activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903980">
        <property type="term" value="P:positive regulation of microglial cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032273">
        <property type="term" value="P:positive regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000167">
        <property type="entry name" value="Tau tubulin kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000358">
        <property type="entry name" value="Tau tubulin kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="34"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="417"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="546"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="713"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="848"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1058"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="730"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="848"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1137"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1202"/>
            <end position="1214"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1270"/>
            <end position="1291"/>
        </location>
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        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1291" mass="143035" checksum="925A801B98EECC24" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEP4</accession>
    <name>A0A670KEP4_PODMU</name>
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        <recommendedName>
            <fullName evidence="9">Max-binding protein MNT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myc antagonist MNT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MNT</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028708083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KEP4"/>
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        <property type="protein sequence ID" value="ENSPMRP00000035346.1"/>
        <property type="gene ID" value="ENSPMRG00000022865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585429"/>
    <dbReference type="KEGG" id="pmua:114585429"/>
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    <dbReference type="GeneTree" id="ENSGT00510000048287"/>
    <dbReference type="OMA" id="THAQVNG"/>
    <dbReference type="OrthoDB" id="5981879at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090398">
        <property type="term" value="P:cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11402">
        <property type="entry name" value="bHLHzip_Mnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000034">
        <property type="entry name" value="MAX network transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF99">
        <property type="entry name" value="MAX-BINDING PROTEIN MNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="218"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="570" mass="62123" checksum="43E41765E8210021" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KER3</accession>
    <name>A0A670KER3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucagon / GIP / secretin / VIP family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucagon family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KER3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037489.1">
        <property type="protein sequence ID" value="ENSPMRP00000035361.1"/>
        <property type="gene ID" value="ENSPMRG00000022879.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000187237"/>
    <dbReference type="OMA" id="INTKRYN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031769">
        <property type="term" value="F:glucagon receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015550">
        <property type="entry name" value="Glucagon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000532">
        <property type="entry name" value="Glucagon_GIP_secretin_VIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11418">
        <property type="entry name" value="GLUCAGON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11418:SF0">
        <property type="entry name" value="PRO-GLUCAGON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00123">
        <property type="entry name" value="Hormone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00070">
        <property type="entry name" value="GLUCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00260">
        <property type="entry name" value="GLUCAGON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025561942" description="Glucagon / GIP / secretin / VIP family domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Glucagon / GIP / secretin / VIP family" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="86" mass="10024" checksum="E7AE8100CCC1E525" modified="2020-06-17" version="1">MKNTQWLYLCGLVVAAFLPVSWQMVLKDSTDESSFTSNVKRHSEGTFTSDFTQYLDKMKAKDFVHWLINAKQYRYVVACKSVFQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KF42</accession>
    <name>A0A670KF42_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Creatine kinase U-type, mitochondrial</fullName>
            <ecNumber evidence="3">2.7.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Acidic-type mitochondrial creatine kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitous mitochondrial creatine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CKMT1A</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Exists as an octamer composed of four MTCK homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17 19">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028562331.1">
        <property type="nucleotide sequence ID" value="XM_028706498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KF42"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037643.1">
        <property type="protein sequence ID" value="ENSPMRP00000035511.1"/>
        <property type="gene ID" value="ENSPMRG00000022960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584545"/>
    <dbReference type="KEGG" id="pmua:114584545"/>
    <dbReference type="CTD" id="548596"/>
    <dbReference type="GeneTree" id="ENSGT00950000182772"/>
    <dbReference type="OMA" id="YLHSCPT"/>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00716">
        <property type="entry name" value="creatine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000002">
        <property type="entry name" value="creatine kinase S-type, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000002">
        <property type="entry name" value="Creatine kinase S-type, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
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</entry>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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    <sequence length="1046" mass="116191" checksum="285E7B7A0EE15858" modified="2020-06-17" version="1"> </sequence>
</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Induces caspases and apoptosis. Counters the protective effect of BCL2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KIR0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037656.1">
        <property type="protein sequence ID" value="ENSPMRP00000035524.1"/>
        <property type="gene ID" value="ENSPMRG00000022967.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166408"/>
    <dbReference type="OMA" id="DMDHSIH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001244">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090200">
        <property type="term" value="P:positive regulation of release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.437.10:FF:000010">
        <property type="entry name" value="BH3-interacting domain death agonist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010479">
        <property type="entry name" value="BID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35447">
        <property type="entry name" value="BH3-INTERACTING DOMAIN DEATH AGONIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35447:SF1">
        <property type="entry name" value="BH3-INTERACTING DOMAIN DEATH AGONIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06393">
        <property type="entry name" value="BID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038018">
        <property type="entry name" value="BID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="179" mass="20205" checksum="05369019DEA9B42A" modified="2020-06-17" version="1">CQDRLISNGAQLTKILLYSFLEKSSDCAFASELCALKNQLVSEQDDDDELQTDGNRFGQPEDNEEEIFRIIGAQLAEIGDQLAAEIDPSLIQNLVRQFMAENMSKEAITNHLSQAVKEVVRRMPLEMERERAMLVVAMVLAKKVANTVPSLLQQVFSTTVNYINQNLRDYVNNLEPEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJE4</accession>
    <name>A0A670KJE4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hexosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CHSY3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Golgi apparatus</location>
            <location evidence="3 14">Golgi stack membrane</location>
            <topology evidence="3 14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A670KJE4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036924.1">
        <property type="protein sequence ID" value="ENSPMRP00000034817.1"/>
        <property type="gene ID" value="ENSPMRG00000022548.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244857"/>
    <dbReference type="OMA" id="CADRVNC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050510">
        <property type="term" value="F:N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000060">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000004">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF40">
        <property type="entry name" value="CHONDROITIN SULFATE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025548658" description="Hexosyltransferase" evidence="16">
        <location>
            <begin position="24"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="802" mass="90528" checksum="15A57FC0D24CFBC4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HL79</accession>
    <name>A0A670HL79_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Putative E3 ubiquitin-protein ligase UBR7</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-recognin-7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase UBR7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">UBR7</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670HL79"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000087.1">
        <property type="protein sequence ID" value="ENSPMRP00000000084.1"/>
        <property type="gene ID" value="ENSPMRG00000000056.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017610"/>
    <dbReference type="OMA" id="GAMVYNH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15542">
        <property type="entry name" value="PHD_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000183">
        <property type="entry name" value="putative E3 ubiquitin-protein ligase UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="18">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="16">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="431" mass="49152" checksum="F6DAD7B6C7D16420" modified="2020-06-17" version="1">MEKEAAASGAGLPGDEGEEGERSAEEPVVSLAEVLAESEELEKEARAVLGGSDHERCSYSQGAVKRQALYACSTCTPPGEDPAGICLACSYECHGTHKLFELYTKRNFRCDCGNSKFKNLQCKLLPEKAMVNPANKYNDNFFGLYCVCKRPYPDPDDEIPDEMIQCIVCEDWFHGRHLGAIPPDSGDFHEMVCQACMDRCPFLWAYAFTDSRHANIRCGCLSFAVHTVTKVTPAAEDQVVLNVEETEEIKKENGIDNQIKTEEEKAAHNNEPSTSSASECSEQTVKKEESTCRFQELKAKQYVQKNRATFWPHNWRSKLCTCKECMKMYCDLEVPFLTEECDTVLAYENKGTSDQEADRRDPLMDTLSSMNRVQQVELISEYNDLKTELTDYLRRFANDGTVVKREDIQQFFEEFQSRKRRRTDRMQYYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HL96</accession>
    <name>A0A670HL96_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HL96"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000274.1">
        <property type="protein sequence ID" value="ENSPMRP00000000261.1"/>
        <property type="gene ID" value="ENSPMRG00000000183.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001753">
        <property type="entry name" value="Si:ch211-119o8.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002196">
        <property type="entry name" value="zinc finger protein 850-like isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF377">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="14">
        <location>
            <begin position="213"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="770" mass="86978" checksum="1957DC2BA6C58B46" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNT3</accession>
    <name>A0A670HNT3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HNT3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001253.1">
        <property type="protein sequence ID" value="ENSPMRP00000001186.1"/>
        <property type="gene ID" value="ENSPMRG00000000877.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182841"/>
    <dbReference type="OMA" id="ADEWGNG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000002">
        <property type="entry name" value="Ferritin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF47">
        <property type="entry name" value="FERRITIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="164" mass="18812" checksum="E92D08B9A0047C2F" modified="2020-06-17" version="1">MSSQVRQNYDAQSEAGVNRLVNQFLHASYNYLSLGFYFTRDDVALSKFSFFFRHLFEEKHEQAENLLTFQNCRGGRVVLQDVKKPERDEWTNGAAAMDAALQLEKNLNQALLDLHKVATSHTDEEVKLIKKLGDHVTNLKRVRAKDEGLGEYLFDRLTLGESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP19</accession>
    <name>A0A670HP19_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">XKR6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028581030.1">
        <property type="nucleotide sequence ID" value="XM_028725197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HP19"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001345.1">
        <property type="protein sequence ID" value="ENSPMRP00000001271.1"/>
        <property type="gene ID" value="ENSPMRG00000000950.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594918"/>
    <dbReference type="KEGG" id="pmua:114594918"/>
    <dbReference type="CTD" id="286046"/>
    <dbReference type="GeneTree" id="ENSGT01140000282533"/>
    <dbReference type="OMA" id="VWVWQTI"/>
    <dbReference type="OrthoDB" id="6356248at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF9">
        <property type="entry name" value="XK-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="656" mass="71929" checksum="1833BF17B8E5ADCA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQD6</accession>
    <name>A0A670HQD6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQD6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002029.1">
        <property type="protein sequence ID" value="ENSPMRP00000001908.1"/>
        <property type="gene ID" value="ENSPMRG00000001403.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154298"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF59">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT C3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="229" mass="24780" checksum="8B0166C4A81370D2" modified="2020-06-17" version="1">MFFTRENCCCADQGRRAQVIVSLSLLLVTDCLRLECVCKKVLVVSGHFSSLHVFTACIFPLLQIKNSSRLLCRPISASVLNRPEVRTKEPCCLSGAHNELLPVLRREFQTSTVSRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARYVWIFEHHAFKSGVTVFVHSLLTEKPGSAAANGLHSVLLSSCFFRPDLGLLCKTCLQCIINWQSSVDIFQGCCAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQR1</accession>
    <name>A0A670HQR1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQR1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002262.1">
        <property type="protein sequence ID" value="ENSPMRP00000002124.1"/>
        <property type="gene ID" value="ENSPMRG00000001554.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="OMA" id="QEGPFQC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000681">
        <property type="entry name" value="zinc finger protein 205 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000902">
        <property type="entry name" value="Zinc finger protein 445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF397">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="14">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="377" mass="43587" checksum="E6A1A4C58BD69080" modified="2020-06-17" version="1">MRREKQRQHFRRLCYQEAEGPRGAYSRLWELCHGWLRVEKDTKEQILELLVLEQLLTILPREMQSWVREHSPETCAQAVALAEDFLLRQREAEREEKQILMPFVEVAVSFTEAGPASANLKPRELCVETKPGGETVLLDYGQGDESKENKYHLEDLKPMEPSQRRARESFPQDHGEEGAFEDEHGPRGQLADHCLGSAMMDRSISPKLDEEAFHGSLRWQKSDSLSVPEEAFQQGPITHDAQEGSYQCAECGKVLSRKDHLKRHQQIHTRKKKPHQCSYCGKCFRQRSDLVFHERIHTGEKPHKCSDCGKNFRSTCQLIVHERTHTREKPYKCSACGKSFSQNANLTVHLRTHTGEKPYKCSTLREDLHPEIPPRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWF1</accession>
    <name>A0A670HWF1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-serine deaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HWF1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004348.1">
        <property type="protein sequence ID" value="ENSPMRP00000004074.1"/>
        <property type="gene ID" value="ENSPMRG00000002777.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00600000084626"/>
    <dbReference type="OMA" id="QTQHLGQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000044">
        <property type="entry name" value="Phenylserine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF19">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="6">
        <location>
            <begin position="45"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="443" mass="49104" checksum="601D6CB6807D05DD" modified="2020-06-17" version="1">MKIISHNEELLRDPVVRPERSSLPACNKFIRFEDISAAAFKIQCGVQKTPCTYSRLSKQYGMDIYLKKEFLQYTGSVKERGVLYLLMSLQQDQQRKGVIVASDTNFSMAVAYHASEHQIPVFVIMSTSTLPARVKMCREYGAMVISYGSTARDAQMHAKRLAQENGYLYLEEEDSSVYLSGLGTMGLEIYEQVPKLDAVIFPAGAHCGLLAGSAAALKHLNEHISVIGVESESFPVLQQSLKIGHPVEDQTRSNHQFYRDVSGPCFGTNSLQLTGKFVDKVVTVREEDILIAMLRLLEYERATVDAEGSIGLAALVTGKLPELKGKRVAVAVCSGNLELSLMRQCIDRALTLDNRVCKFSILISDCPGDISKLLAILAREETRVLDIKQEHMYVASDLFTSEVRKSLSLWQSCTDSVVAVYETATYSHTTGQSNSNGTCIDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HX67</accession>
    <name>A0A670HX67_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-2-oxoglutarate aldolase, mitochondrial</fullName>
            <ecNumber evidence="4">4.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dihydrodipicolinate synthase-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Probable 2-keto-4-hydroxyglutarate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HOGA1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the final step in the metabolic pathway of hydroxyproline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:30687"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:62213"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:35639"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:71685"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.16" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028586394.1">
        <property type="nucleotide sequence ID" value="XM_028730561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HX67"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004637.1">
        <property type="protein sequence ID" value="ENSPMRP00000004344.1"/>
        <property type="gene ID" value="ENSPMRG00000002970.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597588"/>
    <dbReference type="KEGG" id="pmua:114597588"/>
    <dbReference type="CTD" id="112817"/>
    <dbReference type="GeneTree" id="ENSGT00530000063604"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:(R,S)-4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042866">
        <property type="term" value="P:pyruvate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019470">
        <property type="term" value="P:trans-4-hydroxy-L-proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="13">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="342" mass="36765" checksum="CBEF329FF918196B" modified="2020-06-17" version="1">MVRVAVAARLLRLQWQKGPGLRPAGTGAGSAPRRFAAGASAATPSRRLDLRGIYPPLATPFTSQGEVDYSRLEENLRLYSGIPFRGFVVQGSNGEFPYLTQQERLEVVRRVRQAMPKDKLLLAGTGCESTRGTIEMTAQMADKGADAALVVTPCYFRGSMTSAALIHHYKQVAEASPIPVILYSVPANTNLELPTDVVLSLAQHPNIVGIKDSGGNITRIGLLVHKTQHEDFQVLAGSAGFLLASYIVGAAGGICALANVLGSPVCQLEQLCCAGSWDEARALQHRLIEPNIAVTSKFGVPGLKQAMEWFGLNGGFCRSPLLPLSEAQVRELRQDFTSNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXN4</accession>
    <name>A0A670HXN4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger and BTB domain-containing protein 24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Zinc finger protein 450</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ZBTB24</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">May be involved in BMP2-induced transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with MN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HXN4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004761.1">
        <property type="protein sequence ID" value="ENSPMRP00000004464.1"/>
        <property type="gene ID" value="ENSPMRG00000003047.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159373"/>
    <dbReference type="OMA" id="SNHHIQG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18212">
        <property type="entry name" value="BTB_POZ_ZBTB24_ZNF450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000692">
        <property type="entry name" value="Zinc finger and BTB domain containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000267">
        <property type="entry name" value="Zinc finger and BTB domain-containing 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001009">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="18">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="702" mass="79125" checksum="F3C5D7B966CADA01" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZF1</accession>
    <name>A0A670HZF1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HZF1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004892.1">
        <property type="protein sequence ID" value="ENSPMRP00000004585.1"/>
        <property type="gene ID" value="ENSPMRG00000003144.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155611"/>
    <dbReference type="OMA" id="FGICEDG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001042">
        <property type="entry name" value="zinc finger protein 385B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051868">
        <property type="entry name" value="ZN346_ZMAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46144:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46144">
        <property type="entry name" value="ZINC FINGER PROTEIN 385B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="101" mass="11409" checksum="0DCFEEDADC4B1A78" modified="2020-06-17" version="1">MNQSAFLRGFEDKGLRHDRADCQLSKEKKKILFSFCDVCNIQLNSAAQAQVHYNGKSHLKRVKQLNNGKLPANTNTGNLFAGYGKPCSRPGMRSIWRSTCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I034</accession>
    <name>A0A670I034_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Macroglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I034"/>
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        <location>
            <begin position="269"/>
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        </location>
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        <location>
            <begin position="86"/>
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        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17791"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004830.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34203" checksum="E00AD41816966976" modified="2020-06-17" version="1">MPTLGGARPNKRKSVLHKQDLLPLPGPSPHCLTPFSFSQVTPELFRQCGLTRLRREGYIQLVARSPQLPNGVQSLNLRWTARKGYLLLQTDKPIYTPRQKVNFRVFVLDHKLRPTSESVVVTVQNPRGIQVRKVERMPVQFVINDHLSIPDISEPGIWRITAHFTTTPGYNTTTEFEVKKYVLPHFEVTIVPERKYILTSPQQNSDLSIDLQAKFFYGKGVTATAYVRFGVTDGDGGKMYIPGLEQQVTVRNIPALHQLTGLPAGFPEMMMMMMIIIIIIIIIIIIIVVYLWSRALLVSPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0M1</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Episquamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            </authorList>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I0M1"/>
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        <property type="component" value="Chromosome 4"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="105" mass="10885" checksum="A1BA089D0F2D2DD5" modified="2020-06-17" version="1">MGTLRGGNLVVRPTLKALLGMTGVLPSFPFSPLSPFHPLSPWIPLLPFGPGPPTSPFGPMGPIGPTGPLKPISPWTPISPLSPFGPMGPMSPFVPFCPCSPSSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1T7</accession>
    <name>A0A670I1T7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transforming growth factor beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TGFB2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 16">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028580453.1">
        <property type="nucleotide sequence ID" value="XM_028724620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I1T7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006292.1">
        <property type="protein sequence ID" value="ENSPMRP00000005918.1"/>
        <property type="gene ID" value="ENSPMRG00000004011.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594660"/>
    <dbReference type="KEGG" id="pmua:114594660"/>
    <dbReference type="CTD" id="7042"/>
    <dbReference type="GeneTree" id="ENSGT00940000157390"/>
    <dbReference type="OMA" id="NCCLRPF"/>
    <dbReference type="OrthoDB" id="6092228at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:type II transforming growth factor beta receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034714">
        <property type="term" value="F:type III transforming growth factor beta receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006924">
        <property type="term" value="P:activation-induced cell death of T cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035910">
        <property type="term" value="P:ascending aorta morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003289">
        <property type="term" value="P:atrial septum primum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003181">
        <property type="term" value="P:atrioventricular valve morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001974">
        <property type="term" value="P:blood vessel remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060317">
        <property type="term" value="P:cardiac epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060038">
        <property type="term" value="P:cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003215">
        <property type="term" value="P:cardiac right ventricle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010002">
        <property type="term" value="P:cardioblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001502">
        <property type="term" value="P:cartilage condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904888">
        <property type="term" value="P:cranial skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042416">
        <property type="term" value="P:dopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048566">
        <property type="term" value="P:embryonic digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14 16" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10 14" id="KW-0497">Mitogen</keyword>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
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    </evidence>
    <sequence length="413" mass="47911" checksum="448E193E8D66349F" modified="2020-06-17" version="1">MHCYLWSVFLTLDLATVAFALSTCSTLDMDQFMRKRIEAIRGQILSKLKLNSPPEEYPEPEEVPPEVISIYNSTRDLLQEKANHRAATCEKERSDEEYYAKEVYKVDMQPTFQSANLISTNHPIPYFRRVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVSEQRIELYQVLKTKDLTSPMQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDDYYTYPSGEKSLKPSRKKNSGKTPHLLLMLLPSYRVESQQSSRRRKRALDAAYCFRNVQDNCCLRPFYIDFKRDLGWKWIHEPKGYHANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I215</accession>
    <name>A0A670I215_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <text evidence="3">Belongs to the Abd-B homeobox family.</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <sequence length="350" mass="40082" checksum="34CA73A46F68B459" modified="2020-06-17" version="1">MKDNRISLPPVFLSLVELAPYCFHFNHNSKKFLGHYPYCNWTHEYINGSSCFLNVTTMSGRPKVLINNVTTYMTYEQQAACRDFYVWFDWMRKSSRTTCLLQSDLWLFCGTRAYKEIPSAFSGTCTLGIVVPLVYKIDKLPAVRLRNRREVLSPISQYTGTAISRSLLPSLGAAMNYRDLHKLANWTENLFNSTILALKMINKEISEIRNVVLQHHYALDVILASKGGICALIHSHCCMYITDQSTNISATIDHMEQMIAHNPLNPPEGFDPWEWLSSWLPNGLWLRNLLLIVIACIVGFIMVCCCIQCIPSLISQCTAWWYRPRPTTGVTRGIYVAKCRRLGNEVYDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5F5</accession>
    <name>A0A670I5F5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NSFL1 cofactor p47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">p97 cofactor p47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NSFL1C</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I5F5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007439.1">
        <property type="protein sequence ID" value="ENSPMRP00000006953.1"/>
        <property type="gene ID" value="ENSPMRG00000004741.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000055567"/>
    <dbReference type="OMA" id="NKDHTDK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990730">
        <property type="term" value="C:VCP-NSFL1C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904780">
        <property type="term" value="P:negative regulation of protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046604">
        <property type="term" value="P:positive regulation of mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17162">
        <property type="entry name" value="UBX_UBXN2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000020">
        <property type="entry name" value="NSFL1 (p97) cofactor (p47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000093">
        <property type="entry name" value="NSFL1 (P97) cofactor (P47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000001">
        <property type="entry name" value="NSFL1 (P97) cofactor (P47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF24">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="13">
        <location>
            <begin position="207"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="12">
        <location>
            <begin position="319"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="398" mass="43550" checksum="BEB5BBD53D1C6AE5" modified="2020-06-17" version="1">MADREEALREFVAVTGAEEERARFFLESAGGDLQIALASFYEDGGDEDIITLPQPAPSSVTRGTAPRVPPASMKLPVVSCYLEPPSWSHPLECHASDHRVTSFRDLVHAQEEEEEEEEGQRFYAGGSERSGQQIVGPPRKKSPNELVEDLFRGAKEHGAVAVDRAAKSPGEGSRPKPFAGGGYRLGAAPEEESAYVAPEMRQNAAQDVHVVLKLWKSGFSLDSGELRSYQDPSNSQFLESIRRGEVPGELRRLARGGQVNLDLEDHRDEDFTKPRGAFRAFTGEGQKLGSTAPQVMGAGSPSQQAENEAKASSSITIDESEPTTSIQIRLADGGRLVQKFNHSHRIRDVRLFIADARPAMAATSFVLMTTFPNKELTDEDQTLKEANLLNAVIVQRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6E3</accession>
    <name>A0A670I6E3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Methionine synthase</fullName>
            <ecNumber evidence="5 19">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">MTR</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17 19">Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:11173"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19 20">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Monomer. Dimer. Forms a multiprotein complex with MMACHC, MMADHC and MTRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="19">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for normal heme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I6K2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007849.1">
        <property type="protein sequence ID" value="ENSPMRP00000007333.1"/>
        <property type="gene ID" value="ENSPMRG00000004969.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154772"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070453">
        <property type="term" value="P:regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1740:FF:000002">
        <property type="entry name" value="Transmembrane protein 14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="13379" checksum="2D74E1C0404EDD2C" modified="2020-06-17" version="1">MSTDWLGYGYAALVASGGVIGYAKAGSVPSLAAGLLFGGLAGVGAYQQSQDPKNVWLSLIASGTLTGVMGMRFYNSRKFMPAGLIAGASPVHLKIVNGEKVAVITTAAAVLSIKNISLTCIIFHFSVLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I7F0</accession>
    <name>A0A670I7F0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hermansky-Pudlak syndrome 5 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HPS5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the HPS5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028588717.1">
        <property type="nucleotide sequence ID" value="XM_028732884.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028588725.1">
        <property type="nucleotide sequence ID" value="XM_028732892.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028588735.1">
        <property type="nucleotide sequence ID" value="XM_028732902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I7F0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008263.1">
        <property type="protein sequence ID" value="ENSPMRP00000007720.1"/>
        <property type="gene ID" value="ENSPMRG00000005216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598790"/>
    <dbReference type="KEGG" id="pmua:114598790"/>
    <dbReference type="CTD" id="11234"/>
    <dbReference type="GeneTree" id="ENSGT00940000155818"/>
    <dbReference type="OMA" id="EPQCMRR"/>
    <dbReference type="OrthoDB" id="19493at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031084">
        <property type="term" value="C:BLOC-2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000358">
        <property type="entry name" value="Hermansky-Pudlak syndrome 5 protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056499">
        <property type="entry name" value="Beta-prop_HPS5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035431">
        <property type="entry name" value="HPS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056445">
        <property type="entry name" value="TPR_HPS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287:SF18">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287">
        <property type="entry name" value="RUBY-EYE2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23756">
        <property type="entry name" value="Beta-prop_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23758">
        <property type="entry name" value="TPR_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037475">
        <property type="entry name" value="BLOC-2_complex_Hps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPS5-like beta-propeller" evidence="8">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="HPS5 TPR" evidence="9">
        <location>
            <begin position="738"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1147" mass="130668" checksum="044B4172C4AD6362" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I854</accession>
    <name>A0A670I854_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TATA-box binding protein associated factor 5 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TAF5L</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028579848.1">
        <property type="nucleotide sequence ID" value="XM_028724015.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028579849.1">
        <property type="nucleotide sequence ID" value="XM_028724016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I854"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008540.1">
        <property type="protein sequence ID" value="ENSPMRP00000007985.1"/>
        <property type="gene ID" value="ENSPMRG00000005402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594380"/>
    <dbReference type="KEGG" id="pmua:114594380"/>
    <dbReference type="CTD" id="27097"/>
    <dbReference type="GeneTree" id="ENSGT00940000153342"/>
    <dbReference type="OMA" id="HLDMVHC"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033276">
        <property type="term" value="C:transcription factor TFTC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904672">
        <property type="term" value="P:regulation of somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000202">
        <property type="entry name" value="TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000325">
        <property type="entry name" value="TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF6">
        <property type="entry name" value="TAF5-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 5L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="9">
        <location>
            <begin position="66"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="423"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="590" mass="66173" checksum="2D32BA9948625026" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I982</accession>
    <name>A0A670I982_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CHST9</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A670I982"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008781.1">
        <property type="protein sequence ID" value="ENSPMRP00000008214.1"/>
        <property type="gene ID" value="ENSPMRG00000005534.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160563"/>
    <dbReference type="OMA" id="HWNTSAN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001537">
        <property type="term" value="F:dermatan 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF6">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="411" mass="47926" checksum="3A0D12E164FCB702" modified="2020-06-17" version="1">DEAMNLKLVYVSVLMFGIMGLFLFMYLQDWIEEQHTGKITNKLAKSISAVQWKNKQWHGLVILSEEKIQQHAINQKTKNWVTGEKLDKPRKALIEIGHSQGDADPILGMAGSLTTGLSEESQKIKSLLKQFRQVNLPPVLRPLNKTLIKSNHWKTTDEMQEKRRSFLYDFCKRYTGKSRPRTHLTRMVSRIYVEDKHKVLYCEVPKAGCSNWKRVLMVLSGVADSAANITHDAAHYGKHLRKLDSYNLKGIHKRLKTYTKVIFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRLNADRVALATGSGVKFKEFIQYFQLCYPCAINYDYIGKFETLGDDANYFLRLIGAPEGLTFPNFKDRHSSEKRTNLEVVRQYLAEISNTERQQIYNFYYLDYLMFNYSVPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9B8</accession>
    <name>A0A670I9B8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein THEM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">THEM6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THEM6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591885.1">
        <property type="nucleotide sequence ID" value="XM_028736052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I9B8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009013.1">
        <property type="protein sequence ID" value="ENSPMRP00000008430.1"/>
        <property type="gene ID" value="ENSPMRG00000005690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600206"/>
    <dbReference type="KEGG" id="pmua:114600206"/>
    <dbReference type="CTD" id="51337"/>
    <dbReference type="GeneTree" id="ENSGT00390000004859"/>
    <dbReference type="OMA" id="RDIDMCH"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="207" mass="23676" checksum="200E8F2B3D3A0746" modified="2020-06-17" version="1">MAELAWALGALAALFALLDGWYLLRVPVTLLYARWALPTVWDLLEEQSFASRVLPSDLDCLVHMNNARYPREADLARLAHLTRCGLLRAVRGLGAHTVLAASTCRYRRSLHLLERFDVRTRLLGWDARAFVLEQRFVRARDGFVCAVLHVRLHVVGASPAQAVEILCRRKVESPELPEEILHWLKYNEVNSQKLRAESDLQENNKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICH9</accession>
    <name>A0A670ICH9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Influenza virus NS1A binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">IVNS1ABP</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670ICH9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009937.1">
        <property type="protein sequence ID" value="ENSPMRP00000009312.1"/>
        <property type="gene ID" value="ENSPMRG00000006266.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155635"/>
    <dbReference type="OMA" id="MKFDNFA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000039">
        <property type="entry name" value="influenza virus NS1A-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF13">
        <property type="entry name" value="KELCH-LIKE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="411" mass="45221" checksum="4CA83DC632D0FD03" modified="2020-06-17" version="1">MKEVQTLYYSADHKLLDGNLLEGQAEGYGSDDDHIQFVQKKTPRENDLKQISSSSSGSLSPNAAVQSPKHEWKIVASEKISNNTYLCLAVLDGVFCVIFLHGRNSPQNSPTSTPRLMKSLSFEIQPGDLIEKPMSPMQYARSGLGTAELGNKLIAAGGYNREECLRTVECYDPRKDCWTFVAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDPEIDDWTPVPELRTNRCNAGVCALNGKLYIVGGSDPYAKSWTSCASLNIRRHQSAVCELGGHLYIIGGAESWNCLNSVERYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGGFDGSRAVSCVEMYDPAKNEWKMMGSMTIPRSNAGFATVANTIYAVGGFDGNEFLNTVEVYNPESNEWSPYTKIYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDS5</accession>
    <name>A0A670IDS5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Telomeric repeat-binding factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">TERF1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028592530.1">
        <property type="nucleotide sequence ID" value="XM_028736697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IDS5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010484.1">
        <property type="protein sequence ID" value="ENSPMRP00000009838.1"/>
        <property type="gene ID" value="ENSPMRG00000006581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600511"/>
    <dbReference type="KEGG" id="pmua:114600511"/>
    <dbReference type="CTD" id="7013"/>
    <dbReference type="GeneTree" id="ENSGT00940000155268"/>
    <dbReference type="OMA" id="HMENRYF"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071532">
        <property type="term" value="F:ankyrin repeat binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045141">
        <property type="term" value="P:meiotic telomere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008156">
        <property type="term" value="P:negative regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904850">
        <property type="term" value="P:negative regulation of establishment of protein localization to telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904911">
        <property type="term" value="P:negative regulation of establishment of RNA localization to telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905839">
        <property type="term" value="P:negative regulation of telomeric D-loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904792">
        <property type="term" value="P:positive regulation of shelterin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061820">
        <property type="term" value="P:telomeric D-loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.210:FF:000001">
        <property type="entry name" value="Telomeric repeat-binding factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000129">
        <property type="entry name" value="Telomeric repeat-binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.210">
        <property type="entry name" value="Telomere repeat-binding factor, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036507">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017357">
        <property type="entry name" value="TERF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038016">
        <property type="entry name" value="Telomere_bd-1_Pin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63600">
        <property type="entry name" value="Telomeric repeat binding factor (TRF) dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="16 18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="21">
        <location>
            <begin position="318"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="20">
        <location>
            <begin position="318"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="376" mass="43283" checksum="0B77FB54D4FDB622" modified="2020-06-17" version="1">MDVEASLTVSAPVRPPRPSPAAAGPAGRDEAQVPFSQVEAVAAGWMLDFACRCQCRHFCQGNRREFENSRDQALTIIKGLNQIETHQMKTVCLCQLLAYIAEGKSLGFHLGDDEDSSPLEKALLIWTSFLKTQSKQDKLHEDIKRLIQIQAVAVYMEKGYFTESAEVLERIFPESLSNEPLRMKLAAIVKHKDPYHPFLRNFSFSLLIQNIKSYINIFLSEKTDFLTKEAMKEVEARSSGKIMLELQCNSVTESKKENCLETKQSSNRQTCSLASQVPWDSWQLQTPQRKIRRKGSALQNKRELHDPENGQEDTLSLSTSFKRQRWSWEEDEKLKKGVQEFGVGKWTKILLHYDFNHRTNVMLKDRWRTLVRLNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEJ9</accession>
    <name>A0A670IEJ9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="9">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NDUFAF7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028580026.1">
        <property type="nucleotide sequence ID" value="XM_028724193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IEJ9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011023.1">
        <property type="protein sequence ID" value="ENSPMRP00000010350.1"/>
        <property type="gene ID" value="ENSPMRG00000006882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594472"/>
    <dbReference type="KEGG" id="pmua:114594472"/>
    <dbReference type="CTD" id="55471"/>
    <dbReference type="GeneTree" id="ENSGT00390000001588"/>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000001">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="450" mass="50546" checksum="6E984CA7F90C6047" modified="2020-06-17" version="1">MALVQPGRALLRGMRLVARSDRFLRLHGRSTTLKCQCFSSESKAEENSPVTPMLKHLMMKIKSTGPITVAEYMREVLTNPVKGYYMHRDMLGEKGDFVTSPEISQIFGELIGVWFVSEWMAAGKPKKIQLVELGPGRGSLTNDILRVFNQLSSVLSKCDISVHLVEISPKLSEIQASVLTEGKTELTESPTTYMQGITKTRLPIFWYQDLNDVPEGFSFYLAHEFFDALPIHKFQKTEKGWCELLVDIDPDTPDKLRFVLAPSATPAAKAFIHDKESRDHVEVCPDAGIIIQKLAHNIEKNGGNALIVDYGHNGTKTDTFRGFRGHELHNVLISPGTADLTADVDFSYLRKIAQERVTTLGPIKQHDFLKNMGIDIRLQVLLKSVNDAAIQTQLLRSYEMLMDLDKMGGRFHFFAMLPHSRFTASDQQKKSKDSTSHSAFVAGFGELSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFC7</accession>
    <name>A0A670IFC7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphofurin acidic cluster sorting protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PACS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IFC7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010798.1">
        <property type="protein sequence ID" value="ENSPMRP00000010137.1"/>
        <property type="gene ID" value="ENSPMRG00000006091.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183209"/>
    <dbReference type="OMA" id="FANWETD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057541">
        <property type="entry name" value="PACS1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF15">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25332">
        <property type="entry name" value="C2_PACS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2" evidence="5">
        <location>
            <begin position="67"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="4">
        <location>
            <begin position="495"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="711"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25332"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="909" mass="101975" checksum="7A06C819B614BC45" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFL9</accession>
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            <fullName evidence="9">Protein kinase C-binding protein NELL2</fullName>
        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May regulate neuronal differentiation, polarization and axon guidance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IFL9"/>
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        <property type="protein sequence ID" value="ENSPMRP00000010523.1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nuclear envelope"/>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="term" value="P:negative regulation of osteoblast proliferation"/>
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        <property type="entry name" value="Fibrillin 2"/>
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        <property type="entry name" value="Neural EGFL like 2"/>
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        <property type="entry name" value="Complement Module, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="Laminin_G"/>
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        <property type="entry name" value="NOTCH1_EGF-like"/>
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        <property type="entry name" value="PKC-binding_NELL"/>
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    </dbReference>
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        <property type="entry name" value="NEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042:SF2">
        <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FnI-like domain"/>
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    </dbReference>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025390034" description="Protein kinase C-binding protein NELL2" evidence="13">
        <location>
            <begin position="20"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="16">
        <location>
            <begin position="269"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="432"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="552"/>
            <end position="587"/>
        </location>
    </feature>
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        <location>
            <begin position="588"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="16">
        <location>
            <begin position="648"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042609"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50184"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010523.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="803" mass="89518" checksum="A3654EADCBF8B953" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFT6</accession>
    <name>A0A670IFT6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mas-related G-protein coupled receptor member H-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114601263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family. Mas subfamily.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGA6</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FRRS1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <cofactor evidence="1">
            <name>heme b</name>
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        <subcellularLocation>
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            <topology evidence="2">Multi-pass membrane protein</topology>
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    </comment>
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        <text evidence="3">Belongs to the FRRS1 family.</text>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
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    </dbReference>
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        <property type="entry name" value="FERRIC-CHELATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
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    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025435055" evidence="12">
        <location>
            <begin position="23"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="15">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="13">
        <location>
            <begin position="203"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="14">
        <location>
            <begin position="321"/>
            <end position="520"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="577" mass="64262" checksum="173727D0DEB8C4CD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IH73</accession>
    <name>A0A670IH73_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger SWIM-type containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ZSWIM1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028591528.1">
        <property type="nucleotide sequence ID" value="XM_028735695.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591529.1">
        <property type="nucleotide sequence ID" value="XM_028735696.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591530.1">
        <property type="nucleotide sequence ID" value="XM_028735697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IH73"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011995.1">
        <property type="protein sequence ID" value="ENSPMRP00000011228.1"/>
        <property type="gene ID" value="ENSPMRG00000007509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599888"/>
    <dbReference type="KEGG" id="pmua:114599888"/>
    <dbReference type="CTD" id="90204"/>
    <dbReference type="GeneTree" id="ENSGT00390000017273"/>
    <dbReference type="OMA" id="CHFSQTF"/>
    <dbReference type="OrthoDB" id="124789at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048326">
        <property type="entry name" value="ZSWIM1-3_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045563">
        <property type="entry name" value="ZSWIM1/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF0">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19286">
        <property type="entry name" value="ZSWIM1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZSWIM1-3_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="378"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="509" mass="57317" checksum="D3A2104027A9016E" modified="2020-06-17" version="1">MALETVKELLSFDCGLLVAYQVYKSSQLESISFQTSQMRDVFLQHPEVVLIHRTHNPWGKALYTFMVDQPFMQLEGEVTKVIHFAVPTRESAEGLAQMYRTFKAFNPEWKRIKTFLVDPRFRWLPALSEAFPSVDVQLSVFHICKHLQHKIQQVSLEAHTERLVLSALRNGMCAPSESNLRKLYTVLCGFVKPNRLPQLHKEWLLNEKIWAFHRWRTWGQCSQYFKDLEMLTHSLSQIFCIGPSLETCITKIAKTYQKVVQKSSAESAPGPGPLLGENGSSIQNLLVLRSSAANSQRFLLPRDSAPTAAPTPLKPAAGVAAEESAREEEAEVTSREAEERIKQSLSDICTEPAARLCLNEFAVVQSSAQLMGNNGEVASVQILEDAQAVRHKGLSSCTCHFSQTFQLPCRHVLAVLNSEGKAFEPGRIPARWRKGNSTSQEGQSSSDGLLEVLSCSWDKLLDKYLAVSFLTAEISRLLSQCSHEEFDRRYSTLRELADSWIGPYVQVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHL9</accession>
    <name>A0A670IHL9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thymosin beta-4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IHL9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011859.1">
        <property type="protein sequence ID" value="ENSPMRP00000011101.1"/>
        <property type="gene ID" value="ENSPMRG00000007409.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154433"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22059">
        <property type="entry name" value="WH2_BetaT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.520:FF:000001">
        <property type="entry name" value="Thymosin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12021">
        <property type="entry name" value="THYMOSIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12021:SF20">
        <property type="entry name" value="THYMOSIN BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00500">
        <property type="entry name" value="THYMOSIN_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="131" mass="14925" checksum="FC63EA304489D3CF" modified="2020-06-17" version="1">MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAVFSLGTGQPDQVEMQLVLFSELITSSVSKMRPFRPSVLPALFLASLHIDHYHCIHTSVYGRRNRAISFSVNGGNQMTGNLYLFSQEFPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHP6</accession>
    <name>A0A670IHP6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">B-cell receptor CD22 first Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IHP6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012428.1">
        <property type="protein sequence ID" value="ENSPMRP00000011635.1"/>
        <property type="gene ID" value="ENSPMRG00000007795.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000185089"/>
    <dbReference type="OMA" id="RRWILIK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042609">
        <property type="term" value="F:CD4 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042113">
        <property type="term" value="P:B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050859">
        <property type="term" value="P:negative regulation of B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030888">
        <property type="term" value="P:regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056386">
        <property type="entry name" value="Ig_CD22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46958">
        <property type="entry name" value="B-CELL RECEPTOR CD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46958:SF1">
        <property type="entry name" value="B-CELL RECEPTOR CD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24518">
        <property type="entry name" value="Ig_CD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="B-cell receptor CD22 first Ig-like" evidence="8">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="191" mass="21701" checksum="FBC91EF2845D4C89" modified="2020-06-17" version="1">MLFSDLGILGYENMLTIAPNNLAAWEGSCILIPCKIDQTYKNVRVDNFFLIWYFDAKYEDNLKDYTGIMLYNGSSTPKKYLTPTSPHFLDRVRFVGNLASRNCSLKISHLQKNDSGTYGARLYGFVGMKRILDKWFAAAAVNVNGKKLSEIICSPLLRKWSSSLEAKGTSRLSLFCGRDSSAYHQCRFMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670II23</accession>
    <name>A0A670II23_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Acylphosphatase</fullName>
            <ecNumber evidence="4 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ACYP1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4 5">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="4 5"/>
    <dbReference type="RefSeq" id="XP_028575342.1">
        <property type="nucleotide sequence ID" value="XM_028719509.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575353.1">
        <property type="nucleotide sequence ID" value="XM_028719520.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575364.1">
        <property type="nucleotide sequence ID" value="XM_028719531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670II23"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012023.1">
        <property type="protein sequence ID" value="ENSPMRP00000011254.1"/>
        <property type="gene ID" value="ENSPMRG00000007523.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591870"/>
    <dbReference type="CTD" id="97"/>
    <dbReference type="GeneTree" id="ENSGT00390000011103"/>
    <dbReference type="OMA" id="WVRNTSH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000011">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF21">
        <property type="entry name" value="ACYLPHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="99" mass="11230" checksum="4E430BC3D3B1C351" modified="2020-06-17" version="1">MAEGDGLISVDYEVFGKVQGVFFRKNTQTEGKKLGVVGWVQNTDYGTVQGQIQGPTVKVRQLQEWLQKTGSPKSRIDRAEFRNEKKIARLEHSDFCIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIE9</accession>
    <name>A0A670IIE9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Toll like receptor 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TLR7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endomembrane system</location>
            <topology evidence="15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IIE9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011882.1">
        <property type="protein sequence ID" value="ENSPMRP00000011122.1"/>
        <property type="gene ID" value="ENSPMRG00000007429.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159771"/>
    <dbReference type="OMA" id="CNSKYLR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032009">
        <property type="term" value="C:early phagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038187">
        <property type="term" value="F:pattern recognition receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032722">
        <property type="term" value="P:positive regulation of chemokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032727">
        <property type="term" value="P:positive regulation of interferon-alpha production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
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    <sequence length="1035" mass="118312" checksum="616F7C571876B35A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIK4</accession>
    <name>A0A670IIK4_PODMU</name>
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        <submittedName>
            <fullName evidence="5">Myosin light chain 2</fullName>
        </submittedName>
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        <name evidence="5" type="primary">MYL2</name>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="term" value="F:structural constituent of muscle"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:post-embryonic development"/>
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    </dbReference>
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        <property type="term" value="P:ventricular cardiac muscle tissue morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Myosin regulatory light chain 2, atrial isoform"/>
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    </dbReference>
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        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="165" mass="18722" checksum="2E385A584766E2E7" modified="2020-06-17" version="1">MSPKKAKKRSEGANSNVFSMFEQAQIQEFKEAFTIMDQNRDGFIDKADLRDTFAALGRLNVKNEELDDMVKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGLKANYIKEMLMTQGERFSKEEIDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJ24</accession>
    <name>A0A670IJ24_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ETS variant transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ETV2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598424.1">
        <property type="nucleotide sequence ID" value="XM_028742591.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028598425.1">
        <property type="nucleotide sequence ID" value="XM_028742592.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028598427.1">
        <property type="nucleotide sequence ID" value="XM_028742594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IJ24"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012876.1">
        <property type="protein sequence ID" value="ENSPMRP00000012060.1"/>
        <property type="gene ID" value="ENSPMRG00000008048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603527"/>
    <dbReference type="KEGG" id="pmua:114603527"/>
    <dbReference type="CTD" id="2116"/>
    <dbReference type="GeneTree" id="ENSGT00940000166428"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell differentiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
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        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF209">
        <property type="entry name" value="ETS TRANSLOCATION VARIANT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="238"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="334" mass="38542" checksum="70255FD4276418A1" modified="2020-06-17" version="1">MDPWRQCWMEPPLQMVPTGAEVEQLDFMEDYKKVFQEEDFRAVDSWFLPENEVNQPPPSWTGGSYLAELEGFEKEMAFHHTPGLKGFPEYTNTVMELTQVSSTCLDYSALYERDSRLAYQDSSSTSLQVSPYVSAAPQALSSPLCRCSPEEQRPSSQPLLGGQLEQQEPEQDLLGVVTSRDWRKTSGPAVFSQPIPLESDSCRCGPPVRTQMKKESRDWAEANVTHLSHRERTGSGPIQLWRFLLELLQDGSCQAFIRWTGNDWEFKLCDPHEVARRWGKRKNKPRMTYEKLSRGLRYYYHKNIIHKTSGQRYVYRFVCDIQGPMGELAEKLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJ71</accession>
    <name>A0A670IJ71_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IJ71"/>
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        <property type="protein sequence ID" value="ENSPMRP00000012110.1"/>
        <property type="gene ID" value="ENSPMRG00000008091.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="89" mass="10174" checksum="7D814ABD55DA824F" modified="2020-06-17" version="1">MLFFVPSPYTETQEICPTNNHSWLALLYDSDALLCSGMLITPDWVLTAAHCYIWLQTICSPSLVAGSKKWENKKFLPKVIYSIFTERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKA2</accession>
    <name>A0A670IKA2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kelch like family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KLHL1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028584226.1">
        <property type="nucleotide sequence ID" value="XM_028728393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IKA2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013284.1">
        <property type="protein sequence ID" value="ENSPMRP00000012440.1"/>
        <property type="gene ID" value="ENSPMRG00000008315.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596614"/>
    <dbReference type="CTD" id="57626"/>
    <dbReference type="GeneTree" id="ENSGT00940000160425"/>
    <dbReference type="OMA" id="GFEHWGP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021680">
        <property type="term" value="P:cerebellar Purkinje cell layer development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18509">
        <property type="entry name" value="BACK_KLHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18335">
        <property type="entry name" value="BTB_POZ_KLHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000063">
        <property type="entry name" value="Kelch-like protein 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000086">
        <property type="entry name" value="Kelch-like protein 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000027">
        <property type="entry name" value="Kelch-like protein 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF74">
        <property type="entry name" value="KELCH-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
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    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <end position="348"/>
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            <begin position="138"/>
            <end position="153"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="818" mass="90514" checksum="AF0C58EA69D651C3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKG5</accession>
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        <recommendedName>
            <fullName evidence="13">Striatin</fullName>
        </recommendedName>
    </protein>
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        <name evidence="18" type="primary">STRN</name>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26. Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat striatin family.</text>
    </comment>
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    <dbReference type="Ensembl" id="ENSPMRT00000013361.1">
        <property type="protein sequence ID" value="ENSPMRP00000012510.1"/>
        <property type="gene ID" value="ENSPMRG00000007383.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183095"/>
    <dbReference type="OMA" id="KTDLMRR"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070016">
        <property type="term" value="F:armadillo repeat domain binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein phosphatase 2A binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000442">
        <property type="entry name" value="striatin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF2">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="17">
        <location>
            <begin position="50"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="489"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="732"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="778"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="61"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="810" mass="89706" checksum="6FF3F38DFB75227E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INT6</accession>
    <name>A0A670INT6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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                <person name="Rubin C.J."/>
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                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <sequence length="417" mass="45831" checksum="F8B96633E48D8F91" modified="2020-06-17" version="1">IFSCACLFKEKHSTLYYMPSCERQPIVPAHPMAPPSPIITSSNSNNSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKATGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSNGTSRGVGFARMESTEKCEAVIAHFNGKFIKTPPGVSAPAEPLLCKFADGGQKKRQNQNKYIQNGRAWHREGEAGMTLTYDPTTAALQNGFYHSPYSIATNRMITQTSITPYIASPVSAYQVCISRWKDKLLKYLVGICALSWMQPQPYIMQHPGTVLTPSMDHTMSLQPASMISPLTQQMSHLSLGSTGTYMPATTAMQGAYIPQYTHVQTAAVPVEEASGQQQVTVETSSDHSPYTYQQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISD2</accession>
    <name>A0A670ISD2_PODMU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="10 11">
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Afonso S."/>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the CCDC90 family.</text>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="47"/>
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    </feature>
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        <location>
            <begin position="10"/>
            <end position="41"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="293" mass="32936" checksum="F559A55971F6CF47" modified="2020-06-17" version="1">RAFWLRKGRAASSSRRTGSAPAPSRRDSGGAAAARAPSREAGAGRGFASSAWARGAGAQPLGREVRAVERPARNVNIHASYPQLENKSSFPPSGNRKLYFDTHAFVCLLEENGFTTQQSEIIVSALINIINNNMNVIYKDMVTKVQQEIALQQIMSHIGGVKKDMIILEKSEFSALRAENEKIKLQLYQLRKQVMDEVSKVRTDSKLDFNLEKSRTKELYSLNERKQLKMRTEVVELHAQQDRALTQTYRKIDTEVAGLKTMLESHKLDTIKYLAGSVFTCLTVALGFYRLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IT40</accession>
    <name>A0A670IT40_PODMU</name>
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        <submittedName>
            <fullName evidence="6">HECT domain E3 ubiquitin protein ligase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HECTD3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028589475.1">
        <property type="nucleotide sequence ID" value="XM_028733642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IT40"/>
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        <property type="protein sequence ID" value="ENSPMRP00000014629.1"/>
        <property type="gene ID" value="ENSPMRG00000009767.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599082"/>
    <dbReference type="KEGG" id="pmua:114599082"/>
    <dbReference type="CTD" id="79654"/>
    <dbReference type="GeneTree" id="ENSGT00940000159923"/>
    <dbReference type="OMA" id="LMCKHAD"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08666">
        <property type="entry name" value="APC10-HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000025">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042469">
        <property type="entry name" value="HECTD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="215"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="508"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="857" mass="97368" checksum="80461CDA92029114" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IT68</accession>
    <name>A0A670IT68_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IT68"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016006.1">
        <property type="protein sequence ID" value="ENSPMRP00000014986.1"/>
        <property type="gene ID" value="ENSPMRG00000009997.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158490"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed DNA/RNA polymerase mu"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001726">
        <property type="entry name" value="TdT/Mu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF24">
        <property type="entry name" value="DNA-DIRECTED DNA_RNA POLYMERASE MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00871">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="169" mass="18766" checksum="6B78731926781F2C" modified="2020-06-17" version="1">MSQFPVKKKKKKQRLRLPGSPAPLAHPVRFPKVVLCLVEKRMGATRKAFLTTLARQRGFCVEDANSDRVTHVVSEGNSGDEVVEWLLKNGSRGIDVLGGCPALLNTSWFTESMSAGRPAEIEPRHRLQVRKEPSYLAGCGGGVRSIEEYKWYLGKSQLGEQPPPHQTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUI4</accession>
    <name>A0A670IUI4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 53</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP53 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IUI4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016214.1">
        <property type="protein sequence ID" value="ENSPMRP00000015174.1"/>
        <property type="gene ID" value="ENSPMRG00000010121.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235140"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="8">
        <location>
            <begin position="42"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="116"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="369" mass="44393" checksum="30E9F617DAAB3D82" modified="2020-06-17" version="1">MIWRRTRGVSGYRKVSEGVLLVRYKCQETCFRSSFSLVLRVTCEDARTLWSKKHLMEICEDRLAQLALKEELKKQRAREEAAFAALWEEDRLAKEKRAAEDERKRTRWTDGQKNLLEAQQTVADAQRQEARRLKEEEAKLMEEERQLMKLENERAEIERQRKLRECRDMLLDSMEEKRRRLHEEQQEELALDMKILDHIMKESQEDTEKLLKEQQMFKAYLAQQREDEQRQEKELDKLRAEETARMWAKRAAKERAMKEARGRLLTEVMDTRRLQLEEKRKGMLGTRYLELLNAAILEFNPKAYQEELNAQMDYNKQARDLEKEEERRQYALSLEAEKLYQQKIADIISRPYMKLSDLHPLRRYLASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUM8</accession>
    <name>A0A670IUM8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b-245 light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome b(558) alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome b558 subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Neutrophil cytochrome b 22 kDa polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Superoxide-generating NADPH oxidase light chain subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">p22 phagocyte B-cytochrome</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p22-phox</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CYBA</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Component of the phagocyte NADPH oxidase core complex/cytochrome b558 complex, composed of CYBB (heavy chain (beta)) and CYBA (light chain (alpha)). Component of the phagocyte NADPH oxidase complex composed of an obligatory core heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic regulatory subunits NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A. Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX4; this interaction mediates superoxide generation. Interacts with calprotectin (S100A8/9). Interacts with GBP7. Interacts with NOXO1. Forms a heterodimer with NOX3 and is essential for activity and cell membrane localization of NOX3. Interacts with NOX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the p22phox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IUM8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015900.1">
        <property type="protein sequence ID" value="ENSPMRP00000014887.1"/>
        <property type="gene ID" value="ENSPMRG00000009927.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002290"/>
    <dbReference type="OMA" id="WINIFIG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070254">
        <property type="term" value="P:mucus secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900426">
        <property type="term" value="P:positive regulation of defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070257">
        <property type="term" value="P:positive regulation of mucus secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050766">
        <property type="term" value="P:positive regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903428">
        <property type="term" value="P:positive regulation of reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034137">
        <property type="term" value="P:positive regulation of toll-like receptor 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051279">
        <property type="term" value="P:regulation of release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045730">
        <property type="term" value="P:respiratory burst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007732">
        <property type="entry name" value="Cyt_b558_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15168">
        <property type="entry name" value="CYTOCHROME B-245 LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15168:SF0">
        <property type="entry name" value="CYTOCHROME B-245 LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05038">
        <property type="entry name" value="Cytochrom_B558a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="14078" checksum="E66B6EF6F55BC230" modified="2020-06-17" version="1">MGGIEWAMWANEQALASGLILVTGGIVAVAGQFKNWQFAAYSIAAGVFICLLEYPRGKRKKGSTMERCGQKCFTTVVKAFGPLTRNYYVRAFLHICLAVPAAFLLATILGTVCLAIASGIYLLVSRVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUX4</accession>
    <name>A0A670IUX4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dual-specificity kinase</fullName>
            <ecNumber evidence="4">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TESK1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670IUX4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016609.1">
        <property type="protein sequence ID" value="ENSPMRP00000015551.1"/>
        <property type="gene ID" value="ENSPMRG00000010362.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157807"/>
    <dbReference type="OMA" id="SPPTWGD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051650">
        <property type="term" value="P:establishment of vesicle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090521">
        <property type="term" value="P:podocyte cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14155">
        <property type="entry name" value="PKc_TESK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000202">
        <property type="entry name" value="Dual specificity testis-specific protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000134">
        <property type="entry name" value="Dual specificity testis-specific protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF3">
        <property type="entry name" value="DUAL SPECIFICITY TESTIS-SPECIFIC PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="42"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="301"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="430"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="627" mass="67270" checksum="B598862B692EB9AE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVI9</accession>
    <name>A0A670IVI9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IVI9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016570.1">
        <property type="protein sequence ID" value="ENSPMRP00000015514.1"/>
        <property type="gene ID" value="ENSPMRG00000010342.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282552"/>
    <dbReference type="OMA" id="DTHVTHT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15230">
        <property type="entry name" value="7tmA_OR5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="37"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="308" mass="34516" checksum="B9852258E20350DE" modified="2020-06-17" version="1">MLYTVTEFILVGFMDHPDLQVPLFILFLVIYVATIIGNLGIIIVTSVDARLHTPMYFFLRNLSIIDIGYSTAIAPKLLTTFVAEKTTISFKGCTVQFFFLAVFITTEVCLLAVMAYDRFTAICNPLLYFAIMSRKHCTILVVVAYACGLTSSILQTSFIFTLSFCSSNIINHFFCDVPPILKLSCSDTHVTHTVHFVLSTIIALTTFLIVLVSYIAILFAILRISSGRRKAFSTCASHLTAVTVFYGTAIFMYLRPSSKYSVEEDKIISVFYTLAIPMLNPLIYSLRNKEVKEAFKRLVGGKVVSQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXI7</accession>
    <name>A0A670IXI7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription factor IIH subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IXI7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017803.1">
        <property type="protein sequence ID" value="ENSPMRP00000016700.1"/>
        <property type="gene ID" value="ENSPMRG00000011084.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00490000043395"/>
    <dbReference type="OMA" id="INWVEVP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000282">
        <property type="entry name" value="General transcription factor IIH subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="383" mass="42855" checksum="BDBE55C61C5DAEFF" modified="2020-06-17" version="1">MDDEPERTKRWEGGYERTWEVLKEDESGSLKASIEDILFKAKRKRIFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPTRLTCTLKTSFWQVGIIVTKGKRAEKLTELSGNPRKHTAALKKAVDMSCLGEPSLYNALNLAAQTLKHMPGHTSREVLVIFSSLTTCDPSNIYDLIKSLKAVKIRVSIIGLSAEVRVCTVLARETGGTYHVILDESHYRELLMHHVSPPPASSSSESSLIRMGFPQHTIASLTDQDAKPSFSMAQLENSNDPGLTLGGYFCPQCRAKYCELPVECKVCGLTLVSAPHLARSYHHLFPLDAFQEVPLEQYVGERYCQGCHGEITDQHVYICKVCQSAFCVECDLFAHDTLHCCPGCIHKHPAPPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IYR3</accession>
    <name>A0A670IYR3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Small ribosomal subunit protein mS27</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">28S ribosomal protein S27, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial ribosomal protein S27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MRPS27</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the mitochondrion-specific ribosomal protein mS27 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IYR3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017456.1">
        <property type="protein sequence ID" value="ENSPMRP00000016357.1"/>
        <property type="gene ID" value="ENSPMRG00000010916.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007246"/>
    <dbReference type="OMA" id="SILETWH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000232">
        <property type="entry name" value="28S ribosomal protein S27, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034913">
        <property type="entry name" value="mS27/PTCD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019266">
        <property type="entry name" value="Ribosomal_mS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10037">
        <property type="entry name" value="MRP-S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="363"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061536"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="405" mass="46602" checksum="E10104BA65320AA8" modified="2020-06-17" version="1">MAAPVLRRGLQAALRSWAAAGRRCILSAAYVDSSTWEQREKDQQSLVDLATLMDRTYERKLPVSSLTVSRFIDNITSREQVDQAEYYLYKFRHSPNCFYLRDWIIHSWIRQCLKFGAQDKALYTLQNKVQYGIIPDYFTFNILLDSFIKDENYEDAMAVVTEIMIQESFDEVSTQLLSLYVMYKYLTTKSELMWEEERNLGASLFLAGLKETNTVGFSSQLYGLALLGKVELHKGLRAVYHKMPLMWTPGYLNRALQVMEKVTLLPDDTKLCKEAIDVLAATLQPIPVTEVSPEDTKDSEETPKEAKSEEAEMSRLPEYLNRFGVCSLNSKLQSLGKVESASLLTLTTQLVEEKQPAFEVEDIAKHKEKLKEWEQERTLLTERERELREKARQELEAQNAAKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZ52</accession>
    <name>A0A670IZ52_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CCNI2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IZ52"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018583.1">
        <property type="protein sequence ID" value="ENSPMRP00000017453.1"/>
        <property type="gene ID" value="ENSPMRG00000011536.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162679"/>
    <dbReference type="OMA" id="PQRDEIC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20526">
        <property type="entry name" value="CYCLIN_CCNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000006">
        <property type="entry name" value="Cyclin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000052">
        <property type="entry name" value="cyclin-I isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="52"/>
            <end position="138"/>
        </location>
    </feature>
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        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00073755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="367" mass="41575" checksum="59A4519BE85D6552" modified="2020-06-17" version="1">MKCTGPPESQKLALAMEHALARETETWKVPVFHGFTLKGTDISPFYYEKAVLWIRESNSLFQFCSETFALAVSFFNRLLASVKAQLKYLQCIATACLVLAAKINEEDEIIPSVKKLAVQSGCKCSPAEIVRMERIILNKLHWDLYTATSIDFLNIFHAMVMSKWPHLLNGLPQRNPSRHAAFLTKQLQHCMACHQVLQFKGSTLALVIITLELERLTPDWFPVITDLLKKAQIDSTQFIHCKELVDQHLLGFQPSNTVYIFNPANQNIQTHLDKRLPCCYSTVKQTTQINSGARGSWPNSSAFILLRAKTHEDDMQPDEFYDGFKYLYSEDEIPEAGQTSSMGGSDDQRQEESNSTCPPLQPVPQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J241</accession>
    <name>A0A670J241_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transmembrane protein 230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TMEM230</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in trafficking and recycling of synaptic vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028597047.1">
        <property type="nucleotide sequence ID" value="XM_028741214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J241"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019728.1">
        <property type="protein sequence ID" value="ENSPMRP00000018563.1"/>
        <property type="gene ID" value="ENSPMRG00000012185.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602695"/>
    <dbReference type="KEGG" id="pmua:114602695"/>
    <dbReference type="CTD" id="29058"/>
    <dbReference type="GeneTree" id="ENSGT00390000008694"/>
    <dbReference type="OMA" id="AYYAYYK"/>
    <dbReference type="OrthoDB" id="5597044at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098930">
        <property type="term" value="P:axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044234">
        <property type="entry name" value="TMEM230"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664">
        <property type="entry name" value="C20ORF30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="119" mass="13019" checksum="21CDA55C3196A592" modified="2020-06-17" version="1">MPSRTNLAASIPSSKVKYSKLASTDEGYIDLQFKRSPPKIPYKAIALATVLFLIGTLLIIIGGLLLAGYISKGGTDRAIPVLIIGILVFLPGFYHLRIAYFASKGYRGYSYDDIPDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3A6</accession>
    <name>A0A670J3A6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core shell protein Gag P30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J3A6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018971.1">
        <property type="protein sequence ID" value="ENSPMRP00000017822.1"/>
        <property type="gene ID" value="ENSPMRG00000011764.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000031893.1">
        <property type="protein sequence ID" value="ENSPMRP00000030077.1"/>
        <property type="gene ID" value="ENSPMRG00000019450.1"/>
    </dbReference>
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    <dbReference type="OMA" id="HADIRCK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.180">
        <property type="entry name" value="Gamma-retroviral matrix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036946">
        <property type="entry name" value="G_retro_matrix_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050462">
        <property type="entry name" value="Retroviral_Gag-Pol_poly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010999">
        <property type="entry name" value="Retrovr_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33166">
        <property type="entry name" value="GAG_P30 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retroviral matrix proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core shell protein Gag P30" evidence="2">
        <location>
            <begin position="222"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="430" mass="47604" checksum="A247B97CFF663241" modified="2020-06-17" version="1">PPLSLTKGLSKSKLRDLCNIAWVAFTHHLDPAQRWPPHGSFNVTRMQALKAYLADEKPPRQMAVLKPTRPPPYDEIRAQEEQLDRTLVPFYYPEPRAPPSPGPGAGAGRGGAGLREDPANVTPAPSSSASNTSPIVTQPAKPLPSTPNLTEDQTNLDVEPLLNGQLLNGEREGPVASRTRNKDNLPNGEVEGAFPLRALPIPPERAGGPPRMVFTHQPFLTSDLMNWSDKMPSLRDDPDKCHRQVATIFSTHNPTWADVHMLLGALFNEAEKREILAKAGEALTREGYQPNRPASMAPLTTQSILNDPDWDYNTTDGLWGLKIFKKAILDGIKAAGQRTVNWTKVQAVLQGPEEHPSDYYSRLVSAIKTWGGIDPESPQHEVIVKGFFKDQATADIRKEFTYICQTTPYSTSKESYKKLTTNPLIFLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J624</accession>
    <name>A0A670J624_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease A-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pancreatic ribonuclease family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J624"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020211.1">
        <property type="protein sequence ID" value="ENSPMRP00000019034.1"/>
        <property type="gene ID" value="ENSPMRG00000012434.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166697"/>
    <dbReference type="OMA" id="NCHEGEV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RNase_A_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease A-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001427">
        <property type="entry name" value="RNaseA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036816">
        <property type="entry name" value="RNaseA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023411">
        <property type="entry name" value="RNaseA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023412">
        <property type="entry name" value="RNaseA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437:SF65">
        <property type="entry name" value="ANGIOGENIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00074">
        <property type="entry name" value="RnaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00794">
        <property type="entry name" value="RIBONUCLEASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00092">
        <property type="entry name" value="RNAse_Pc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54076">
        <property type="entry name" value="RNase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00127">
        <property type="entry name" value="RNASE_PANCREATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease A-domain" evidence="7">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="162" mass="18520" checksum="28D45831A2724D2E" modified="2020-06-17" version="1">MFSPFLPLLFPPRKFLDATMLISSCLLVRLAILLSVVLVQSCEGQSWKAFQNKHIDYPQTRASNPSAYCNLMMVKRNLNPSRCKPRNTFINHDKESVLQVCGNGGKQWQGKFYDSNENFPMIDCSFTDGKPPKDCKYKGTETSKRVRVTCENKKPVHLEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J6L5</accession>
    <name>A0A670J6L5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial ribosomal protein S24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MRPS24</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
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    <dbReference type="RefSeq" id="XP_028597086.1">
        <property type="nucleotide sequence ID" value="XM_028741253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J6L5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020093.1">
        <property type="protein sequence ID" value="ENSPMRP00000018917.1"/>
        <property type="gene ID" value="ENSPMRG00000012371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602716"/>
    <dbReference type="KEGG" id="pmua:114602716"/>
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    <dbReference type="GeneTree" id="ENSGT00390000011179"/>
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    <dbReference type="OrthoDB" id="5950413at2759"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
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        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="175" mass="19791" checksum="F5A2CCDE303DBEAC" modified="2020-06-17" version="1">MAAPWWRAAAAARRGLEAFVGSPGNTSWHLSARRDFRTSVACCKNRAARVRVGKGDKPVTYEEAHPPHFIAHRKGWLSQHTSNLSGEGGAAERSVEDVFIRKLIYGTFHGCLASDIVLKRRANTLVICAIFLQKLRPSKFYFLIGYTETLLSFLYKCPVKMEVQTVREKVVYKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J777</accession>
    <name>A0A670J777_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ADAM metallopeptidase domain 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ADAM22</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J777"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020680.1">
        <property type="protein sequence ID" value="ENSPMRP00000019479.1"/>
        <property type="gene ID" value="ENSPMRG00000011571.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156889"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022011">
        <property type="term" value="P:myelination in peripheral nervous system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099645">
        <property type="term" value="P:neurotransmitter receptor localization to postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000014">
        <property type="entry name" value="disintegrin and metalloproteinase domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF14">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025694880" evidence="14">
        <location>
            <begin position="28"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="16">
        <location>
            <begin position="231"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="15">
        <location>
            <begin position="431"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="776"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="876"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="931" mass="103122" checksum="46792351A1DBF007" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8F7</accession>
    <name>A0A670J8F7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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</entry>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1080:FF:000007">
        <property type="entry name" value="Nuclear Pore complex Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1080">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058779">
        <property type="entry name" value="Ig_NUP210_13th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057586">
        <property type="entry name" value="Ig_NUP210_16th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056897">
        <property type="entry name" value="Ig_NUP210_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056898">
        <property type="entry name" value="Ig_NUP210_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055099">
        <property type="entry name" value="Ig_NUP210_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056899">
        <property type="entry name" value="Ig_NUP210_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055094">
        <property type="entry name" value="NUP210_Ig15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055095">
        <property type="entry name" value="NUP210_Ig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF2">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26181">
        <property type="entry name" value="Ig_NUP210_13th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26183">
        <property type="entry name" value="Ig_NUP210_14th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22959">
        <property type="entry name" value="Ig_NUP210_15th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25354">
        <property type="entry name" value="Ig_NUP210_16th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24991">
        <property type="entry name" value="Ig_NUP210_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26182">
        <property type="entry name" value="Ig_NUP210_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24935">
        <property type="entry name" value="Ig_NUP210_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22962">
        <property type="entry name" value="Ig_NUP210_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26184">
        <property type="entry name" value="Ig_NUP210_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24902">
        <property type="entry name" value="Ig_NUP210_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22957">
        <property type="entry name" value="NUP210_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025524089" evidence="10">
        <location>
            <begin position="27"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1801"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="11">
        <location>
            <begin position="448"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1896" mass="207862" checksum="0BD958C5E5C06D4E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAG2</accession>
    <name>A0A670JAG2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JAG2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022804.1">
        <property type="protein sequence ID" value="ENSPMRP00000021488.1"/>
        <property type="gene ID" value="ENSPMRG00000013942.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003000">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002196">
        <property type="entry name" value="zinc finger protein 850-like isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="358" mass="40801" checksum="CCE80373E0C5D273" modified="2020-06-17" version="1">MKETDPAKLARMEGGRWTVDLVRLSPASLPTTSERSLSGTSKRSGDLHGWSWRDGDELEGKNKGDQNRIHIAEKSYKYSECGENIHQSSQSTSHQRKSFVRSDSFTSHERTKSREKLYQCRECGKSFSQSSNLTSHHRIHTGEKPYQCFECGKSFKEGTTLSSHQRIHTGEKPYNCMECGKSFSCSHHLTSHQRIHTGEKPYHCLQCGKSFRRKHHLTPHQRIHTGEKPYQCLECGKSFSQGSHLTSHQKIHTGEKLYQCFECGKSFSQSASLTSHHRIHTGEKPYQCFECGKSFSRSASLTSHQRIHTGEKPYQCFECGKSFSQGISLTSHQRIHTEGQPKRKKGKIIKQPLQNTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAR2</accession>
    <name>A0A670JAR2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JAR2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022587.1">
        <property type="protein sequence ID" value="ENSPMRP00000021280.1"/>
        <property type="gene ID" value="ENSPMRG00000013822.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="MLTSHQM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001808">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF226">
        <property type="entry name" value="ZINC FINGER PROTEIN 60-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="500" mass="58195" checksum="11B3B17416C823AC" modified="2020-06-17" version="1">MEENHRIMDSLGAEELQMNEEDLDKIHTQEKPLKYSGPGKRFSQSSHSTSNLTNLLGKKLYQCLECGKNFCRKSRLTYHQVTHSGEKPYQCLQCGKRFSWKRSFASHQKIHTGEKPYQCLECGKSFKRKDALTFHQRIHTGEKPYQCMECGKSFSRKHSLTFHQRSHTGEKPYTCLECGKSFSQRASLTVHQRIHTGEKPYRCLECGKGFYGKNMLTSHQKVHTGEKPYQCLECGKSFRHKGELTVHQRIHTGEKPYQCMECEKSFTQKSSLTSHQRFHTGEKPYECLECGKRFSWKTMLTSHQMIHTGENPYTCLECGKSFNRKDSLTLHQRTHTGEKPYQCLECGKSFTQRAGLMYHKRIHTGEKPYQCVECGKSFTHRAGLVSHERFHTGEKPYECLECGKRFSWKTMLTSHQMIHTGENPYPCLECGKSFNRKDSLTSHQRIHTGEKPYQCLECGKSFTQRAGLMYHRRIHMRRNHISAWNVESVAFKEPVSLLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAX6</accession>
    <name>A0A670JAX6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JAX6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022728.1">
        <property type="protein sequence ID" value="ENSPMRP00000021414.1"/>
        <property type="gene ID" value="ENSPMRG00000013907.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000022735.1">
        <property type="protein sequence ID" value="ENSPMRP00000021421.1"/>
        <property type="gene ID" value="ENSPMRG00000013907.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001244"/>
    <dbReference type="OMA" id="GHREGHP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
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            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="460" mass="52340" checksum="BF3B59121A00F77F" modified="2020-06-17" version="1">MEYCNPLLLTNWYFYHFSASYMTTTFVMEAMAAANAQLRWKRMEKHKDDDEDSSSGVSDSDVLLPEGYERSETRPILSLQRRGAPNVFEITERVEMGQMASMFFNKVGVNLFYFCIIIYLYGDLAIYAAAVPVSLMQVTCSVTGNHSCSVEDGTKYNDTDKCWGPIRRIDAYRIYLAAFTILLGPFTFFNVQKTKYLQILTSLMRWIAFVIMIIIALLRISKGKGEGHPPLAQLSGIRNLFGVCVYSFMCQHSLPSLITPISKKKHVNKLVLLDYTLILGFYSLLSFTAIYCFKNGTLMDMYTLNFTSCDIVNIAVIRYFLGLFPVFTISTNFPIIAVTLRNNWKTLFHREGGTYPWVVDRIFFPVITLIPPIIVAFCTHDLESLVGITGAYAGNGIQYIIPAFLAYCSRKDTQLIFGNGTLNKHLSPFRHTFWIGFVLLWGLFCFLFVTANIILSETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBU4</accession>
    <name>A0A670JBU4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier family 35 member B4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC35B4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028601360.1">
        <property type="nucleotide sequence ID" value="XM_028745527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JBU4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023275.1">
        <property type="protein sequence ID" value="ENSPMRP00000021918.1"/>
        <property type="gene ID" value="ENSPMRG00000014249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604928"/>
    <dbReference type="KEGG" id="pmua:114604928"/>
    <dbReference type="CTD" id="84912"/>
    <dbReference type="GeneTree" id="ENSGT00390000002915"/>
    <dbReference type="OMA" id="NPFTGWH"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006111">
        <property type="term" value="P:regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="334" mass="38088" checksum="397F8BEA037D18E4" modified="2020-06-17" version="1">MHPGLAVGLVFGGCCSNVVFLELLIREFPGCGNLITFAQFFFIAIEGFIFEANFGRKRPTIPIRYYLIMVAMFFTVSVVNNYALNLNIAMPLHMIFRSGSLIANMALGIIILKKRYTISKYTSIALVSLGIFTCTFMSAKQVSSMSSPSEDEENVSAFIWWLLGILALTFALLMSARMGIFQETLYKRFGKHSKEALFYNHALPIPGFLLLAPDIYRHALLFSQSEPFQVPVIGVTLPIMWFYLIMNIITQYVCIRGVFILTTECTSLTVTLVLTLRKFISLIFSILYFRNPFTAWHWIGTLFVFVGTLMYTEVWNNLGPLLDRKQKKQEEKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JCE0</accession>
    <name>A0A670JCE0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JCE0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023380.1">
        <property type="protein sequence ID" value="ENSPMRP00000022011.1"/>
        <property type="gene ID" value="ENSPMRG00000014310.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154844"/>
    <dbReference type="OMA" id="CESEACV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF73">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="32"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="233" mass="25958" checksum="9FE3AC33056FAFDF" modified="2020-06-17" version="1">LCRLQGEETGAGEPAAARYGKAVRIPQEDKEESEPCIVLLGKAGVGKSATGNTLLGREKFHSAFSAKPTTQNVEKASGEFKGQKFSVIDTPAVSSSESLKQHKREIKKLRKSSPYVLVLVTTVGRFTPEDKKTAKKVKKVFRKKFGKRMLVLFTHKEDLKGESLKDYVEKSENKVKKLVEKCGNCCFALNNKAAGEEKEEASKLLMEKLWEILHRDGSRPCTEKGKEEERGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JCG2</accession>
    <name>A0A670JCG2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein Mdm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MDM4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MDM2/MDM4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028590090.1">
        <property type="nucleotide sequence ID" value="XM_028734257.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028590092.1">
        <property type="nucleotide sequence ID" value="XM_028734259.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028590093.1">
        <property type="nucleotide sequence ID" value="XM_028734260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JCG2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023559.1">
        <property type="protein sequence ID" value="ENSPMRP00000022178.1"/>
        <property type="gene ID" value="ENSPMRG00000014437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599291"/>
    <dbReference type="KEGG" id="pmua:114599291"/>
    <dbReference type="CTD" id="4194"/>
    <dbReference type="GeneTree" id="ENSGT00530000063539"/>
    <dbReference type="OMA" id="IPDCRRT"/>
    <dbReference type="OrthoDB" id="24526at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd17673">
        <property type="entry name" value="MDM4"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd16784">
        <property type="entry name" value="mRING-HC-C2H2C4_MDM4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MDM4"/>
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        <property type="entry name" value="p53_neg-reg_MDM_2/4"/>
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    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
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        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858">
        <property type="entry name" value="OS05G0521000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858:SF12">
        <property type="entry name" value="PROTEIN MDM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500699">
        <property type="entry name" value="MDM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006748">
        <property type="entry name" value="p53_MDM_2/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DM2" evidence="11">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="469" mass="52670" checksum="1C3B5838A0B9928C" modified="2020-06-17" version="1">MSSSTSTQYLSPESACRTSPQQVKQLRPKPPLLKILRAAGAQGETFTLKELVHYLGEYISKKQLYDKKQQHMVYCGGDQLGDLLGCESFSVNDPRPVYEMLKRNVTSVTVTVTDAAQRLALAKDQSMNNPSQEQLKQSSTDRNCTYGRKENEVDTPALSVSNTFKEDEDNLSKEQPTLDLVLEEWDVAGLPWWFLGNLRNNYKSRSNGSTDIHTNQDVDTTIVSDTTDDLWFLNEAASDQFGVTIPAKTIDCDHASEEGKDGSKTVSEAESSDDFEDSQSLNDDTDIDPPSKDYWQCTKCKKFNSPIKRYCFRCWALRKDWFSDCPMLAHSLSSSNIATMQSKEDTEGIDVPDCRRTVSAPLMQSKDPCRSEIKPNLRPGSSVDSLDLAGKEPLLQFGKHKEKWSLESSKELLKPCIMCQKRPRNGNIVHGRTAHLVACFTCAKMLKKGQSPCPVCKRQIQMVIRTFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JDA4</accession>
    <name>A0A670JDA4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PAK4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670JDA4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023545.1">
        <property type="protein sequence ID" value="ENSPMRP00000022165.1"/>
        <property type="gene ID" value="ENSPMRG00000014429.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159792"/>
    <dbReference type="OMA" id="QRDQPGD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060996">
        <property type="term" value="P:dendritic spine development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000352">
        <property type="term" value="P:negative regulation of endothelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120183">
        <property type="term" value="P:positive regulation of focal adhesion disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06657">
        <property type="entry name" value="STKc_PAK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000073">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF9">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="547"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="249"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="817" mass="91436" checksum="89A8A85AE210B0DC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEV3</accession>
    <name>A0A670JEV3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PCCB</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670JEV3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022997.1">
        <property type="protein sequence ID" value="ENSPMRP00000021667.1"/>
        <property type="gene ID" value="ENSPMRG00000013315.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157741"/>
    <dbReference type="OMA" id="ENTSYMF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="286"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="540" mass="58717" checksum="75DA7497DDF41E10" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JH61</accession>
    <name>A0A670JH61_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670JH61"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025467.1">
        <property type="protein sequence ID" value="ENSPMRP00000024003.1"/>
        <property type="gene ID" value="ENSPMRG00000015488.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157351"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000027">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000042">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF93">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="356"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="534" mass="58666" checksum="2D550000805B1F2D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JIH5</accession>
    <name>A0A670JIH5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the chemokine-like receptor (CMKLR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JIH5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025724.1">
        <property type="protein sequence ID" value="ENSPMRP00000024256.1"/>
        <property type="gene ID" value="ENSPMRG00000015675.1"/>
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    <dbReference type="GeneTree" id="ENSGT01020000230438"/>
    <dbReference type="OMA" id="QEDEYFT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:complement receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="C3a anaphylatoxin chemotactic receptor"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000826">
        <property type="entry name" value="Formyl_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225">
        <property type="entry name" value="CHEMOTACTIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225:SF70">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00526">
        <property type="entry name" value="FMETLEUPHER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="56"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="213" mass="24565" checksum="FD8D654C6FCD12DB" modified="2020-06-17" version="1">MIFIRFQEDEYFTGNGEQLFENTTSSHTDRYLGLQKRMHLLSIVIYSVSCLLGVTGNGLVIWIAGFKMKKTVKVVWFLNLAIADFVFTFFLPFSIAYTSLGFHWPFGKLLCKLNSTIAFLNMFASVFLLMIISMDRCALVVYPVWSRNYRTTKLAYGIALVTWVTAFIISSPYLIFRDTATNSRNVTSCFNNFALMNAHYYLIFYFVLIKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJD9</accession>
    <name>A0A670JJD9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SPC25</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JJD9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026049.1">
        <property type="protein sequence ID" value="ENSPMRP00000024551.1"/>
        <property type="gene ID" value="ENSPMRG00000015863.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002220"/>
    <dbReference type="OMA" id="KNINEFW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="13">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="218" mass="25384" checksum="105A99B211F971A1" modified="2020-06-17" version="1">MAQEKGDDELAKLAEHMKELWTKFKTTCSNEKIDQTLRLSDLCMESLCKLSDKWSNRLIDGDKMITKFHEYTDEACQKNKSIEEKQEKLSEVLADLKDGRKEEADLMATIQELREELIIKSKIKSKPPEEIMERLHKSEKLFKERLGLEIRKTGASHLQFIFRCVDHKDLEKPYILTLTINEEGAYEVVSCFPPLDCIEELQQKGKLFASGQKKYHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJW1</accession>
    <name>A0A670JJW1_PODMU</name>
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            <fullName evidence="3">Beta-2-microglobulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">B2M</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-2-microglobulin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028706284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JJW1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024713.1">
        <property type="protein sequence ID" value="ENSPMRP00000023272.1"/>
        <property type="gene ID" value="ENSPMRG00000015115.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584425"/>
    <dbReference type="KEGG" id="pmua:114584425"/>
    <dbReference type="CTD" id="567"/>
    <dbReference type="GeneTree" id="ENSGT00940000165013"/>
    <dbReference type="OMA" id="WCVVLVW"/>
    <dbReference type="OrthoDB" id="9949628at2759"/>
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        <property type="component" value="Chromosome 14"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Beta-2-microglobulin"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLH1</accession>
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        <recommendedName>
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            <taxon>Bifurcata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Wallerman O."/>
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                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
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                <person name="Feiner N."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <location>
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            <end position="491"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="597" mass="66505" checksum="2441835198219217" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JN70</accession>
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        <submittedName>
            <fullName evidence="5">Myosin light chain 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MYL10</name>
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    <organism evidence="5 6">
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Chromosome 15"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Myosin regulatory light chain 2, atrial isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_dom"/>
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    <dbReference type="InterPro" id="IPR050403">
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        </recommendedName>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Chromosome 5"/>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>A0A670JRJ0</accession>
    <name>A0A670JRJ0_PODMU</name>
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        <submittedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <location>
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            <end position="588"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Episquamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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            <end position="475"/>
        </location>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="954" mass="112164" checksum="1A9BD53F0ECB66A9" modified="2020-06-17" version="1"> </sequence>
</entry>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Episquamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the HMGA family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
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        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN HMGI-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23341">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEINS HMG-A AND C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATHOOK"/>
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        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
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            <end position="84"/>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="187" mass="20345" checksum="287C2F2A071F9631" modified="2020-06-17" version="1">MSARAEGAGQPSTSGSAAAAAAASQEQPATSEPPKRGRGRPRKQPQEPMGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWYSRTLAPKCLGSETFQLPDSRKPEVSVPVFECSFGSQTSYGASAASDWLQELPAANRKPHFGSRTFRKSNRLPERILFNFGGTTVLFLVVNHFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JU77</accession>
    <name>A0A670JU77_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claw keratin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114587046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avian keratin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JU77"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029721.1">
        <property type="protein sequence ID" value="ENSPMRP00000028021.1"/>
        <property type="gene ID" value="ENSPMRG00000018087.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000186896"/>
    <dbReference type="OMA" id="GSKGLGX"/>
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        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003461">
        <property type="entry name" value="Keratin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203:SF1">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02422">
        <property type="entry name" value="Keratin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0416">Keratin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="166" mass="15648" checksum="0B4CD2199F34A237" modified="2020-06-17" version="1">MADCGPSCAVPSCASTPTVGFGSAGGLGYGYGGLGNGYGGLGYGYGGLGYGYGGAERASNLGVLAGVAPSCVNQIPPAEVVVQPPPIVLTIPGPILSASCEPVSVGGNTPCAAGGYGSGFGGGFGGGFGRGLYGGAGLLGSSSGGLGGRGRYGYVGRRGSICYTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUF4</accession>
    <name>A0A670JUF4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JUF4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029170.1">
        <property type="protein sequence ID" value="ENSPMRP00000027505.1"/>
        <property type="gene ID" value="ENSPMRG00000017741.1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="566"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1210" mass="142282" checksum="1DC92B397A29521B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVC3</accession>
    <name>A0A670JVC3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crystallin zeta like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CRYZL1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028582928.1">
        <property type="nucleotide sequence ID" value="XM_028727095.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028727096.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028582931.1">
        <property type="nucleotide sequence ID" value="XM_028727098.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028582932.1">
        <property type="nucleotide sequence ID" value="XM_028727099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JVC3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030962.1">
        <property type="protein sequence ID" value="ENSPMRP00000029193.1"/>
        <property type="gene ID" value="ENSPMRG00000018867.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596061"/>
    <dbReference type="CTD" id="9946"/>
    <dbReference type="GeneTree" id="ENSGT00390000013113"/>
    <dbReference type="OMA" id="AHHWGAK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042633">
        <property type="entry name" value="CRYZL1"/>
    </dbReference>
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        <property type="entry name" value="ER"/>
    </dbReference>
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44461">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44461:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="355" mass="39686" checksum="D24C638C80603196" modified="2020-06-17" version="1">MKGLYWQQNSSGEETTFVFLEKDNLPVTRDNYVKVQVKACALSWINDKLLSEIKIKKEFLPVGREIAGVVLETGNKVTFFQPNDEVVGILPLDSEESGLCEVVLVHEHYLAHKPEKVSWLEAAGTIRDGLRAYTALHYLSYATPGKTVLVMDGASPFGTIAIQLAQHRGAKVISTIYSLEDKQYLERLTPSVGVKQPLVARIIDETNGTCDLTESCLEETGGLGVDIILDAGVRLYSKENEVTSQQLLPHKHDIISLLSVGGHWVTMEENLQLDPPDSRCLFLKGATVSFLNDEVWNLSNMQQGKYLCILEDVMEKLSSGVFRPHLDDPIPLYEAKVSMEMVQKNEARKRQVIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWQ9</accession>
    <name>A0A670JWQ9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ArfGAP with FG repeats 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AGFG2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JWQ9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030078.1">
        <property type="protein sequence ID" value="ENSPMRP00000028355.1"/>
        <property type="gene ID" value="ENSPMRG00000018291.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161071"/>
    <dbReference type="OMA" id="SKFHIAR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001675">
        <property type="term" value="P:acrosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007289">
        <property type="term" value="P:spermatid nucleus differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000005">
        <property type="entry name" value="Arf-GAP domain and FG repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052248">
        <property type="entry name" value="Arf-GAP_FG-repeat_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134:SF4">
        <property type="entry name" value="ARF-GAP DOMAIN AND FG REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134">
        <property type="entry name" value="DRONGO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="559" mass="58898" checksum="60819CB09800483C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWZ0</accession>
    <name>A0A670JWZ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JWZ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031614.1">
        <property type="protein sequence ID" value="ENSPMRP00000029808.1"/>
        <property type="gene ID" value="ENSPMRG00000019274.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159706"/>
    <dbReference type="OMA" id="VELMICK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF30">
        <property type="entry name" value="CALPAIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="14"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="390" mass="44189" checksum="6DE86DAD5F0E54A6" modified="2020-06-17" version="1">KEVRLASTRARGDLYKDLAFPANDDSLFFNYSTPLAHFRGEICWLRPQEICSTPRLFSDNQYEWQVKQGMLGDCWFLCACAALQKSKYLLAKVIPPGQPSWRDEKYRGCFTCRVWQFGHWVEVTIDDRLPCLGGKLCFSQCQTEDVFWLPLLEKAYAKYGAWIYEQLWAGQVADALVDLTGGLAERWSLKDPGRSTERERAGKVLEKAVFRRLMNLKEKCVMSCSVFSSRQGKHARTGEFHAFIVVDMQDLSKVSRKEIILLRIRNPWGRRCWKGPWREGGQSPFLHLKDLWTRRTFRWHTLSSIHLLKPQELSFSISPRSPTCQPSWHSASSGRCLGTSGLAGANTLLALALSLVGCLGGAILISLPQCPGCSIGPGALWEIKNGSFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXJ9</accession>
    <name>A0A670JXJ9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Mitotic spindle assembly checkpoint protein MAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Mitotic arrest deficient 1-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MAD1L1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MAD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JXJ9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031835.1">
        <property type="protein sequence ID" value="ENSPMRP00000030023.1"/>
        <property type="gene ID" value="ENSPMRG00000019410.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001316"/>
    <dbReference type="OMA" id="YKLDFMP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990706">
        <property type="term" value="C:MAD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990728">
        <property type="term" value="C:mitotic spindle assembly checkpoint MAD1-MAD2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
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        <location>
            <begin position="103"/>
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        <location>
            <begin position="352"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00075803"/>
        </source>
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        <source>
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    <sequence length="639" mass="74713" checksum="16C74056FDAEFFCF" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <scope>IDENTIFICATION</scope>
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            <begin position="23"/>
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    </feature>
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        <source>
            <dbReference type="Pfam" id="PF17919"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028790.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    <sequence length="120" mass="13121" checksum="1E9F169D77EC094D" modified="2020-06-17" version="1">VDPVFTRPLTAMTHDSAPDQLQWTAEALEAFECIKRELRSSPALGLPDYRLPFSLFVHENKGVASGVLTQPFQGRNRPVAYYSLQLDTTVLGNVGCLRAVAAAALLLEKAQETVLGHELT</sequence>
</entry>
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    <accession>A0A670K0W3</accession>
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        <name type="scientific">Podarcis muralis</name>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    <sequence length="82" mass="9555" checksum="1934A7C4F56F3271" modified="2020-06-17" version="1">PLGSFNSFNDIRSKLEMVLPRAATRFHQKINCVTFPHPDAMPEQQLLKPSEWSYCDYFWVSEQPPICSLLQQPGFIQYVAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6U9</accession>
    <name>A0A670K6U9_PODMU</name>
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            <fullName evidence="10">WD40 repeat-containing protein SMU1</fullName>
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        <alternativeName>
            <fullName evidence="11">Smu-1 suppressor of mec-8 and unc-52 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SMU1</name>
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    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the spliceosome B complex. Interacts with IK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028568171.1">
        <property type="nucleotide sequence ID" value="XM_028712338.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000033283.1"/>
        <property type="gene ID" value="ENSPMRG00000021580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587703"/>
    <dbReference type="KEGG" id="pmua:114587703"/>
    <dbReference type="CTD" id="55234"/>
    <dbReference type="GeneTree" id="ENSGT00940000155007"/>
    <dbReference type="OMA" id="MMKQQEP"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMU1, DNA replication regulator and spliceosomal factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000754">
        <property type="entry name" value="SMU1, DNA replication regulator and spliceosomal factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000082">
        <property type="entry name" value="WD40 repeat-containing protein SMU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="14">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="513" mass="57532" checksum="E62E268B24A69019" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9F5</accession>
    <name>A0A670K9F5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane 6 superfamily member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TM6SF2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TM6SF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K9F5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034989.1">
        <property type="protein sequence ID" value="ENSPMRP00000032980.1"/>
        <property type="gene ID" value="ENSPMRG00000021377.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012913"/>
    <dbReference type="OMA" id="VQMLMYM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21106">
        <property type="entry name" value="TM6SF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047195">
        <property type="entry name" value="TM6SF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059044">
        <property type="entry name" value="TM_Tm6sf1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568:SF9">
        <property type="entry name" value="TRANSMEMBRANE 6 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568">
        <property type="entry name" value="TRANSMEMBRANE SUPERFAMILY 6 MEMBER 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26083">
        <property type="entry name" value="TM_Tm6sf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="217"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="374" mass="42031" checksum="A2C0AEB64D51A7C3" modified="2020-06-17" version="1">MVKPRKTKQVASFSLFLTLDPSLFSPPFHLLLACSPSAIAVTAFGILLFLFALVYSASDSEDALFYVFVVLSFVSGISAVIVLEEDGYISNFLEGYMRQGEPYLSTAHGMMNCYWAATTHFALQLAMIAAITQRKSFRNLGLYWVGSLTMNFSVYLLGNVVGKYGSEIRPDFFLNIPLLLALIWAASRIFAQPKTLSLETADKVSEEQRKSLLQRPLDLVLVGFLLFNVSFTLFRGLVVLDCKADVCFDYINQQEPYLRDPVAYPKIQMLVFLFYGLPYFCLCLYGLLTPGSSWMPDWALISAGAIAQAQFSHIGSSLHQHTPFPYRTPESAWWLVTLFNLAYAVGPHLLVYRCLRNPAFFSPVVSQDDIKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAK9</accession>
    <name>A0A670KAK9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036649.1">
        <property type="protein sequence ID" value="ENSPMRP00000034548.1"/>
        <property type="gene ID" value="ENSPMRG00000022416.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166555"/>
    <dbReference type="OMA" id="ICSANNE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="474"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1251"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1282"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1297"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1365" mass="150748" checksum="08432236C226ADB0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAL5</accession>
    <name>A0A670KAL5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lebercilin-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Leber congenital amaurosis 5-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LCA5L</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCA5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KAL5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034622.1">
        <property type="protein sequence ID" value="ENSPMRP00000032649.1"/>
        <property type="gene ID" value="ENSPMRG00000021152.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00560000077266"/>
    <dbReference type="OMA" id="MKHQETQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026188">
        <property type="entry name" value="Lebercilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028933">
        <property type="entry name" value="Lebercilin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16650">
        <property type="entry name" value="C21ORF13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16650:SF9">
        <property type="entry name" value="LEBERCILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15619">
        <property type="entry name" value="Lebercilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lebercilin" evidence="6">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="278"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="512" mass="58847" checksum="115DAEC748690A36" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAN6</accession>
    <name>A0A670KAN6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maternal embryonic leucine zipper kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MELK</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670KAN6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034647.1">
        <property type="protein sequence ID" value="ENSPMRP00000032674.1"/>
        <property type="gene ID" value="ENSPMRG00000021155.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154889"/>
    <dbReference type="OMA" id="NVCTPKS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008631">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061351">
        <property type="term" value="P:neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12198">
        <property type="entry name" value="MELK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14078">
        <property type="entry name" value="STKc_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14341">
        <property type="entry name" value="UBA_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000901">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000004">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="MELK"/>
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    <dbReference type="InterPro" id="IPR048637">
        <property type="entry name" value="MELK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21594">
        <property type="entry name" value="UBA_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="84"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="21">
        <location>
            <begin position="672"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017168"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="721" mass="81569" checksum="459FF612FD673F71" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KD95</accession>
    <name>A0A670KD95_PODMU</name>
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        <submittedName>
            <fullName evidence="2">Family with sequence similarity 222 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM222B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KD95"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035630.1">
        <property type="protein sequence ID" value="ENSPMRP00000033584.1"/>
        <property type="gene ID" value="ENSPMRG00000021770.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063811"/>
    <dbReference type="OMA" id="THTQMNT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029340">
        <property type="entry name" value="FAM222"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN FAM222A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16070:SF1">
        <property type="entry name" value="PROTEIN FAM222B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAM222A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="100"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="509"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="509" mass="53422" checksum="A60EFDC4203FDF99" modified="2020-06-17" version="1">MRAAQQHPTPAELDAYAKKVASHPLTIKIFPNSVKVPQRKHIRRTVNGLDTSGQRYSPYPPSQASVKTGLLAIVRSPPAKGIVKDFDGTRTRLLPEAMMNPPSAPYAAPSTLSHPQALARQQALQHAQGLAQQHPQGIPTALQQPQHPQSMAHPALQPPPHHANHLLQQQQQQPPAAGLHGGRKMADADAPPNVTVSTSTIPLSMAATLQQNQPPDLSSIVHQINQFCQARAGISATSVCEGQIANPSPISRNLLISASTRVSAHNVPTPLPSCVVDPGVPPSGPGAMGVPPLGGVVGRGPPAYQSEMKQVAAWNQHQLAHLQQMCGEAVGPSGLMGKPPGRELPGQGFAGKAPGYALDLCMGQPFNVKPPLEKPTPSPPVNSLPGPAPYTNGHYFQPLWNNILPTPNSDSSGSQDLAMPFHGGGGGQPLGAGLECTGGPHYRAGAGGPPAQGGLMQTMEYLSGDFQHSCLREQQGGGGVLSKAPRPAMNRAHDPADSRSLHIQHPGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDI3</accession>
    <name>A0A670KDI3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-directed RNA polymerase III subunit L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114582287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028559035.1">
        <property type="nucleotide sequence ID" value="XM_028703202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KDI3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036532.1">
        <property type="protein sequence ID" value="ENSPMRP00000034435.1"/>
        <property type="gene ID" value="ENSPMRG00000022359.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582287"/>
    <dbReference type="KEGG" id="pmua:114582287"/>
    <dbReference type="GeneTree" id="ENSGT00390000007087"/>
    <dbReference type="OMA" id="MCHVDLI"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="67" mass="7647" checksum="D0948DF667FE69CE" modified="2020-06-17" version="1">MIIPVRCFTCGKVVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLSHVDLIEKLLNYAPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFX4</accession>
    <name>A0A670KFX4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription termination factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114588941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KFX4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037976.1">
        <property type="protein sequence ID" value="ENSPMRP00000035831.1"/>
        <property type="gene ID" value="ENSPMRG00000023146.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159729"/>
    <dbReference type="OMA" id="MSFRSDT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:termination of RNA polymerase I transcription"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053078">
        <property type="entry name" value="TTF1-like"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="784"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1006" mass="114562" checksum="D65C050C12681A30" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KHQ0</accession>
    <name>A0A670KHQ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">C-terminal PDZ ligand of neuronal nitric oxide synthase protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Nitric oxide synthase 1 adaptor protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KHQ0"/>
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        <property type="protein sequence ID" value="ENSPMRP00000035830.1"/>
        <property type="gene ID" value="ENSPMRG00000023149.1"/>
    </dbReference>
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    <dbReference type="OMA" id="TRFQCDF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050998">
        <property type="term" value="F:nitric-oxide synthase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01270">
        <property type="entry name" value="PTB_CAPON-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000124">
        <property type="entry name" value="carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF80">
        <property type="entry name" value="CARBOXYL-TERMINAL PDZ LIGAND OF NEURONAL NITRIC OXIDE SYNTHASE PROTEIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00067706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="352" mass="38996" checksum="5005C71D9BC9C3F0" modified="2020-06-17" version="1">MPVKLKNRYNLVDDAGDSRVPLHNEEAFQHGIHFQAKYIGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVNIIISVDGVKVILRKKQKRKEWAWDEGKMEVMHDPVYRIFYVSHDSQDLKIFSYIARDGANNSFRCNVFKSKKKTQAMRVVRTVGQAFEVCHKLSLQHALQNADGQADGASNNSADDPQVEGFQLAGAAMADEENGPEGAFAPDFGSCELRLAAPNLGVPQSGMILKDRSSQENETGSLRPSTAQPLGSPASPSSSASVTPLASQHCLQLLQHQLLQQQQQTQVAAAQVTMPLPVWQPPDCTFFDAVFSRSPPTSFPNPLLHYCGVCVCERGRATNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIV9</accession>
    <name>A0A670KIV9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Centromere protein V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CENPV</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028563833.1">
        <property type="nucleotide sequence ID" value="XM_028708000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KIV9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039180.1">
        <property type="protein sequence ID" value="ENSPMRP00000036996.1"/>
        <property type="gene ID" value="ENSPMRG00000023824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585393"/>
    <dbReference type="KEGG" id="pmua:114585393"/>
    <dbReference type="CTD" id="201161"/>
    <dbReference type="GeneTree" id="ENSGT00390000003183"/>
    <dbReference type="OMA" id="FNGNEWE"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="104"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="231" mass="24868" checksum="887C45B0F42ACE63" modified="2020-06-17" version="1">MGKAKRTPAAAAATRKGPQSGGRKAPAPPPPAPIPSSPRDRASSKGKAAPPGKATPAAPEELCALALGAQKERWLQFQKRQRVSCEEAARLLLDTFEYQGLVKHTGGCHCGAVRFEVWASADLHVFDCNCSICVKKQNKHFIVPASHFKLLKGADSLATYTFNTHCAQHTFCKTCGVQSFYTPRSNPDGYGIAPHCLDEGTVSSVTIEAINGKEWEKAVKGHPTIRSMSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KNN0</accession>
    <name>A0A670KNN0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rho GTPase-activating protein 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Rho-type GTPase-activating protein 17</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with NHERF1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KNN0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038791.1">
        <property type="protein sequence ID" value="ENSPMRP00000036622.1"/>
        <property type="gene ID" value="ENSPMRG00000023560.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156201"/>
    <dbReference type="OMA" id="MSLANTH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04386">
        <property type="entry name" value="RhoGAP_nadrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000001">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000019">
        <property type="entry name" value="rho GTPase-activating protein 17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="BAR" evidence="17">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="16">
        <location>
            <begin position="243"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="499"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="652" mass="72301" checksum="61549021DDF1978D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KPS5</accession>
    <name>A0A670KPS5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multidrug and toxin extrusion protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
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    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    </feature>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
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                <person name="Bunikis I."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <dbReference type="ChEBI" id="CHEBI:456216"/>
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    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
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        <cofactor evidence="1">
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    <dbReference type="FunFam" id="3.30.200.20:FF:000494">
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
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        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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    <feature type="compositionally biased region" description="Basic residues" evidence="13">
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
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            <end position="1722"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="2079" mass="226685" checksum="B8A48EAFB1C9BEA1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HM00</accession>
    <name>A0A670HM00_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA acetyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ACAT2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028579652.1">
        <property type="nucleotide sequence ID" value="XM_028723819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HM00"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000938.1">
        <property type="protein sequence ID" value="ENSPMRP00000000884.1"/>
        <property type="gene ID" value="ENSPMRG00000000659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594303"/>
    <dbReference type="KEGG" id="pmua:114594303"/>
    <dbReference type="CTD" id="39"/>
    <dbReference type="GeneTree" id="ENSGT01030000234626"/>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="275"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="5">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="396" mass="41183" checksum="CE89175C3DEC7898" modified="2020-06-17" version="1">MDAGGEGVVLVAAVRTPVGSFNGALSTLHAHELASVAIKETLKRAKIGPKEVSEVIFGQVLAAGAGQNPARQASVAAGIPYEIPAWSCQMICGSGLKAVCLGAQSIMIGDSSIVVAGGMESMSKAPHVIHMRNGLKMGEASLQDTLILDGLTDAFYHYHMGITAENVAKQWQVSREEQDQLAVQSQNKAENAQKAGYFDKEIVPVPVPSRKGPVEVKADEHPRPGTKLETMAKLKPFFITDGTGTVTAANASGLNDGAAAVILMKKAEALKRGLAPLARIVSWAQAGVDPSVMGIAPVSAIKKALEKAGWTVDQVDLYEINEAFAALGCAVTKELKLNPEKVNIEGGAVALGHPLGASGCRILVTLVHALERTGGKRGVAALCIGGGMGIAMCVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMG6</accession>
    <name>A0A670HMG6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PCNX2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000001126.1">
        <property type="protein sequence ID" value="ENSPMRP00000001064.1"/>
        <property type="gene ID" value="ENSPMRG00000000649.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157374"/>
    <dbReference type="OMA" id="NHKIPSN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039797">
        <property type="entry name" value="Pecanex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007735">
        <property type="entry name" value="Pecanex_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372:SF5">
        <property type="entry name" value="PECANEX-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05041">
        <property type="entry name" value="Pecanex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="887"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="974"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="Pecanex C-terminal" evidence="8">
        <location>
            <begin position="1553"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1805"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2000"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2044"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1820"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1839"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1866"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2053"/>
            <end position="2063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="2063" mass="231096" checksum="180FC19060EB2C5B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMU6</accession>
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        <submittedName>
            <fullName evidence="3">Protein phosphatase 6 regulatory subunit 3</fullName>
        </submittedName>
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        <name evidence="3" type="primary">PPP6R3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591659.1">
        <property type="nucleotide sequence ID" value="XM_028735826.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000000826.1"/>
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    <dbReference type="GeneTree" id="ENSGT00390000009899"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein phosphatase regulator activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="SAPS"/>
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    <dbReference type="PANTHER" id="PTHR12634:SF12">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY SUBUNIT 3"/>
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    </dbReference>
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        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="878" mass="98813" checksum="2AE19C9EC87C554D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNC8</accession>
    <name>A0A670HNC8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114594915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028581024.1">
        <property type="nucleotide sequence ID" value="XM_028725191.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028581025.1">
        <property type="nucleotide sequence ID" value="XM_028725192.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028581026.1">
        <property type="nucleotide sequence ID" value="XM_028725193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HNC8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001230.1">
        <property type="protein sequence ID" value="ENSPMRP00000001163.1"/>
        <property type="gene ID" value="ENSPMRG00000000858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594915"/>
    <dbReference type="KEGG" id="pmua:114594915"/>
    <dbReference type="GeneTree" id="ENSGT00390000014037"/>
    <dbReference type="OMA" id="HWHASPR"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05272">
        <property type="entry name" value="TDH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="58"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="376" mass="42036" checksum="E16DE2FA107E578D" modified="2020-06-17" version="1">MPAMRSLSRAVKQVLQKPGCGCQVAVVPVRCLGFSPRQVASDASFHSVSFSESDHPRVLITGGLGQLGVGLAKLLRKRFGKNNVILSDIRKPPDNVFHSGPFIYSDILDYKNLREIVVNNRITWLFHYSALLSAVGEANVPLARSVNITGLHNILDIAAEHSLRLFVPSTIGAFGPTSPRNPTPDLCIQRPRTIYGVSKVHAELMGEYYHYRYGLDFRCLRYPGIISADSQPGGGTTDYAVQIFHDAMKTGKFQCNLKPDTRLPMMYIDDCLRATLEIMEAPAEGLSMRTYNISALSFTPEELVQEVQKHIPELEVSYKVDAVRQAIADSWPMIFDDSNARQDWGWKHDYDLPDLVNTMFTFLDSTRSISRVAQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP13</accession>
    <name>A0A670HP13_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PPARG related coactivator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PPRC1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="gene ID" value="ENSPMRG00000001390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592164"/>
    <dbReference type="KEGG" id="pmua:114592164"/>
    <dbReference type="GeneTree" id="ENSGT00940000154488"/>
    <dbReference type="OMA" id="PINSEGA"/>
    <dbReference type="OrthoDB" id="9005460at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001872">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000551">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
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    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="14">
        <location>
            <begin position="156"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="749"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="774" mass="87107" checksum="00543FF407B50F01" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQL2</accession>
    <name>A0A670HQL2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycerophosphodiester phosphodiesterase domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GDPD4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
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        <property type="gene ID" value="ENSPMRG00000001524.1"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23344:SF13">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23344">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="9">
        <location>
            <begin position="110"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="520" mass="59642" checksum="D7D9BDC01CDC16DC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HR58</accession>
    <name>A0A670HR58_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speedy/RINGO cell cycle regulator family member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SPDYA</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            <authorList>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the Speedy/Ringo family.</text>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <source>
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    <sequence length="213" mass="25800" checksum="689BC8A371106AC4" modified="2020-06-17" version="1">MYFHLITNCVCFPSCMIRNEDALLKKPFQKEKQSKVAHRQVATDEWDREEARNQRFHFLALDAYARHKKMVNDYILYYGGKKEDFKRSGENDKTDLDIIRENHRFLWREEDEADMNWEKRLSKKYYDKLFKEYCIADLTKYKENKFGFRWRHEKEVVSGKGQFSCGSKHCDEKEGLKSWEVNFGYVEHGEKKNALVKLRLCPECSYKLNFHHR</sequence>
</entry>
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    </protein>
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        <lineage>
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            <taxon>Episquamata</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPCR_3_CS"/>
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        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCRMGR"/>
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    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="78"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="342" mass="37721" checksum="88FE3E6DD2F522F0" modified="2020-06-17" version="1">FFAVNNSSWVLLPTCQSPNAIVLSANLRCVTDVRIPKCVFLYADANECTRCPEDQHPNEDRDQCVPKIFTFLSYEEYLGSLLASLALSLSLTTGFVLGIFIKYKETPIVKANNRDLSYILLISLLLSFLSSFLFIGRPRKVTCLLRQTAFSLIFSAAVSSVLAKTITVVLAFLATKPGNKVRRWLGKSLAHSIVISCSSVQVLICTIWLGISPPFPDFDLSSQLGEIIVQCNEGSVAMFYSSLGYMGFLAAICFTVAFLARNLPGAFNEAKLITFSMLIFCSVWVSFVPTYLSTKGKFMVAVQIFSILASSAGLLGCIFIPKCYIIILRPDLNTKEHLTTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTP6</accession>
    <name>A0A670HTP6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HTP6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003128.1">
        <property type="protein sequence ID" value="ENSPMRP00000002921.1"/>
        <property type="gene ID" value="ENSPMRG00000002103.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154136"/>
    <dbReference type="OMA" id="FISHRIV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="403" mass="46277" checksum="06BA1B0B7D889567" modified="2020-06-17" version="1">MWPAGLSRFWRTRAAHGNAVYLPARAVPLTFFDRITSLVDEGNAVDVAYLDFSKAFNKVPHYILVEKLVKCGLDYATTQWICNWLTDRTQRVLINGSSSSWRRVTSGVPQGSVLGPVLFNIFINDLDDGLKGILIKFADDTKLGGVANTPEDRITLQNDLGRLENWAKTNKMNFNREKCKVLHLGKKNERHKYKMGDTWLESSTCEKDLGVLVDHKLDMSQQCDAAAKKANAILGCINRSIASRSREVIVPLYSALVRPHLEYCVQFWAPQFKKDTDKLERVQRRATKMVKGLETMPYEERLRELGMFSLEKRRLRGDMIAMFKYIKGCHIEEGERLFSAAPEKRTRSNGSKLQERRFHLNIRKNFLTVRAVRQWNLLPRSVVESPSLEVFKQRLDNHMSGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HV77</accession>
    <name>A0A670HV77_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E2F transcription factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">E2F6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028578391.1">
        <property type="nucleotide sequence ID" value="XM_028722558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HV77"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003867.1">
        <property type="protein sequence ID" value="ENSPMRP00000003608.1"/>
        <property type="gene ID" value="ENSPMRG00000002524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593806"/>
    <dbReference type="KEGG" id="pmua:114593806"/>
    <dbReference type="CTD" id="1876"/>
    <dbReference type="GeneTree" id="ENSGT00940000155734"/>
    <dbReference type="OMA" id="XPSKIRI"/>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="6">
        <location>
            <begin position="62"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="276" mass="31634" checksum="AB52F2736CF952CD" modified="2020-06-17" version="1">MAAPAVGHSPEQPSVLLPQLSMDLLQAHIKVENEDDVHFVSFNRKETPFVKVKKSINSRKPRYDGSLVHLTRRFMDLVKVSPEGVLDLNEVSRTLGVRKRRVYDITNVLDGIHLIQKRSKNLIQWVGSDIKHITIRTPEHQKLRDELYDLTEMEEALDELIKDSAHQLYDLTDDKEKARLAYVTYQDIRSIQTFQEQIVIAIKAPEETKMEVPAPKQDCIEVRIKSTKGPIDVYLCEVPLDDPNADVLKNMDNISCESRQAVDDYGVCNIRDTKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWW0</accession>
    <name>A0A670HWW0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HWW0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003871.1">
        <property type="protein sequence ID" value="ENSPMRP00000003612.1"/>
        <property type="gene ID" value="ENSPMRG00000002526.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00980000198589"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33426:SF30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33426">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="585" mass="64195" checksum="EC8FE3E6EE5118EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HX61</accession>
    <name>A0A670HX61_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nuclear valosin-containing protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NVL</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="13">Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with NCL/nucleolin. Isoform 1 and isoform 2 interact with TERT and isoform 1 exhibits a higher binding affinity for TERT compared to isoform 2. Isoform 1 interacts with MTREX in an ATP-dependent manner; the interaction is required to associate NVL with nuclear RNA exosome. Isoform 1 interacts with RPL5 in an ATP-dependent manner. Interacts with WDR74 (through WDR repeats); the interaction is independent of RNA or pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028580374.1">
        <property type="nucleotide sequence ID" value="XM_028724541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HX61"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004627.1">
        <property type="protein sequence ID" value="ENSPMRP00000004334.1"/>
        <property type="gene ID" value="ENSPMRG00000002952.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594624"/>
    <dbReference type="KEGG" id="pmua:114594624"/>
    <dbReference type="CTD" id="4931"/>
    <dbReference type="GeneTree" id="ENSGT00570000079239"/>
    <dbReference type="OMA" id="GLWSTHR"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032206">
        <property type="term" value="P:positive regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904749">
        <property type="term" value="P:regulation of protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905323">
        <property type="term" value="P:telomerase holoenzyme complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2010:FF:000001">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000063">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000172">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000600">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038100">
        <property type="entry name" value="NLV2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031996">
        <property type="entry name" value="NVL2_nucleolin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16725">
        <property type="entry name" value="Nucleolin_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="286"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="610"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="88"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="852" mass="94504" checksum="3B301772872739DE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXL0</accession>
    <name>A0A670HXL0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="6">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ACVRL1</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18673"/>
            <dbReference type="Rhea" id="RHEA-COMP:11022"/>
            <dbReference type="Rhea" id="RHEA-COMP:11023"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028566352.1">
        <property type="nucleotide sequence ID" value="XM_028710519.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028566362.1">
        <property type="nucleotide sequence ID" value="XM_028710529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HXL0"/>
    <dbReference type="SMR" id="A0A670HXL0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004741.1">
        <property type="protein sequence ID" value="ENSPMRP00000004444.1"/>
        <property type="gene ID" value="ENSPMRG00000003041.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586744"/>
    <dbReference type="KEGG" id="pmua:114586744"/>
    <dbReference type="CTD" id="94"/>
    <dbReference type="GeneTree" id="ENSGT00940000164733"/>
    <dbReference type="OMA" id="TIHAENQ"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070724">
        <property type="term" value="C:BMP receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14142">
        <property type="entry name" value="STKc_ACVR1_ALK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23534">
        <property type="entry name" value="TFP_LU_ECD_ALK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000064">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF66">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RECEPTOR R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0464">Manganese</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12 27" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025468820" description="receptor protein serine/threonine kinase" evidence="27">
        <location>
            <begin position="23"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="29">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="28">
        <location>
            <begin position="201"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="502" mass="56683" checksum="4920AA105574C09C" modified="2020-06-17" version="1">MRQRAIAGLFVAIMSLPRNIEAAGGKDLVNCVCEHPNCLNSTCTGKLCFVSKHLTEGVMIHKKGCLQSMSEFCRGSHTTNTAIICCSTDMCNLNRTIQLPGEENQPEEESPSLKNLLLMTLVPLFAFLVLAALVGLSVWKVFQSRQRRIRLRSDDLEDMDFILKASTLGDSTLKNLLNDDCTTGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRATWHGENVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDYLQHTALDVESCLLFANSIICGLLHLHVEIFGTQGKPAIAHRDLKSRNILVKNNKQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEQIQMDRFESFKRTDIWAYGLVLWEIARRTVVNGIVEDYKPPFFDMVPIDPSFDDMKKVVCIDQQTPTIPNRLYSDVTLSALAKIMKECWFQSPPARLTALRIKKTLKKLSDSFDKPKQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HYU9</accession>
    <name>A0A670HYU9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/potassium-transporting ATPase subunit beta-1-interacting protein</fullName>
            <shortName evidence="7">Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein</shortName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NKAIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HYU9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004675.1">
        <property type="protein sequence ID" value="ENSPMRP00000004380.1"/>
        <property type="gene ID" value="ENSPMRG00000002993.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157989"/>
    <dbReference type="OMA" id="SHQYIIN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008516">
        <property type="entry name" value="Na/K-Atpase_Interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084:SF3">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084">
        <property type="entry name" value="T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05640">
        <property type="entry name" value="NKAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="103" mass="12040" checksum="2C6711AE3036EC12" modified="2020-06-17" version="1">VCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVICFYLEAGDLSKIDIGHLVILKMEKKKIALHWSRCRIAVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0G0</accession>
    <name>A0A670I0G0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">General transcription factor IIF subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Transcription initiation factor IIF subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GTF2F2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028584650.1">
        <property type="nucleotide sequence ID" value="XM_028728817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I0G0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005687.1">
        <property type="protein sequence ID" value="ENSPMRP00000005336.1"/>
        <property type="gene ID" value="ENSPMRG00000003658.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000005695.1">
        <property type="protein sequence ID" value="ENSPMRP00000005344.1"/>
        <property type="gene ID" value="ENSPMRG00000003658.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000005701.1">
        <property type="protein sequence ID" value="ENSPMRP00000005350.1"/>
        <property type="gene ID" value="ENSPMRG00000003658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596936"/>
    <dbReference type="KEGG" id="pmua:114596936"/>
    <dbReference type="CTD" id="2963"/>
    <dbReference type="GeneTree" id="ENSGT00390000016051"/>
    <dbReference type="OMA" id="PIADNCY"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015849">
        <property type="entry name" value="TFIIF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="10">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="262" mass="29958" checksum="4E8D7C32D0BEE148" modified="2020-06-17" version="1">MSDKGELDLAGAKQNTGMWLVKVPKYLSQQWNKASGRGEVGKLRIAKNQGRTEVSFTLNEDLANIDDIGGKPTSISAPREHPFLLQSVGGQMLTVFTESSLESQTDEKPEISNSEKLSLEGIVVQRAECRPAANENYMKLKRLQIEESSKPVSWTMQLDKAVTTNYKPVANHQYNIDYEKKKKEDGKRARAEKQQVLDMLFSAFEKHQYYNIKDLVDITKQPVSYLKEILREIGIYNVKGTHKNTWELKPEYRHYQGEDKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I2F8</accession>
    <name>A0A670I2F8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED23</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000006425.1">
        <property type="protein sequence ID" value="ENSPMRP00000006041.1"/>
        <property type="gene ID" value="ENSPMRG00000003806.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010380"/>
    <dbReference type="OMA" id="QKHQKQR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000409">
        <property type="term" value="P:positive regulation of T cell extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1362" mass="155986" checksum="B43689A9C1D92BFE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I372</accession>
    <name>A0A670I372_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine zipper putative tumor suppressor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein LAPSER1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">LZTS2</name>
        <name evidence="9" type="synonym">LAPSER1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cytoskeleton</location>
            <location evidence="9">Microtubule organizing center</location>
            <location evidence="9">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the LZTS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028586287.1">
        <property type="nucleotide sequence ID" value="XM_028730454.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586288.1">
        <property type="nucleotide sequence ID" value="XM_028730455.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586289.1">
        <property type="nucleotide sequence ID" value="XM_028730456.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586291.1">
        <property type="nucleotide sequence ID" value="XM_028730458.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586292.1">
        <property type="nucleotide sequence ID" value="XM_028730459.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586293.1">
        <property type="nucleotide sequence ID" value="XM_028730460.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586294.1">
        <property type="nucleotide sequence ID" value="XM_028730461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I372"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006754.1">
        <property type="protein sequence ID" value="ENSPMRP00000006336.1"/>
        <property type="gene ID" value="ENSPMRG00000004294.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597545"/>
    <dbReference type="KEGG" id="pmua:114597545"/>
    <dbReference type="CTD" id="84445"/>
    <dbReference type="GeneTree" id="ENSGT00940000154078"/>
    <dbReference type="OMA" id="AHCMSHS"/>
    <dbReference type="OrthoDB" id="10030037at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048147">
        <property type="term" value="P:negative regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051168">
        <property type="term" value="P:nuclear export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060682">
        <property type="term" value="P:primary ureteric bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051255">
        <property type="term" value="P:spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072197">
        <property type="term" value="P:ureter morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03026">
        <property type="entry name" value="LZTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028597">
        <property type="entry name" value="LZTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354:SF4">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06818">
        <property type="entry name" value="Fez1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="294"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="443"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="636" mass="70135" checksum="9708AE1155BA3F24" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3X7</accession>
    <name>A0A670I3X7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Regulator of telomere elongation helicase 1</fullName>
            <ecNumber evidence="16">5.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">RTEL1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_028591335.1">
        <property type="nucleotide sequence ID" value="XM_028735502.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000007007.1">
        <property type="protein sequence ID" value="ENSPMRP00000006575.1"/>
        <property type="gene ID" value="ENSPMRG00000004441.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000007021.1">
        <property type="protein sequence ID" value="ENSPMRP00000006589.1"/>
        <property type="gene ID" value="ENSPMRG00000004441.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000007051.1">
        <property type="protein sequence ID" value="ENSPMRP00000006618.1"/>
        <property type="gene ID" value="ENSPMRG00000004441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599787"/>
    <dbReference type="KEGG" id="pmua:114599787"/>
    <dbReference type="CTD" id="51750"/>
    <dbReference type="GeneTree" id="ENSGT00950000182970"/>
    <dbReference type="OMA" id="EDPNTHS"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000732">
        <property type="term" value="P:DNA strand displacement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902990">
        <property type="term" value="P:mitotic telomere maintenance via semi-conservative replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904506">
        <property type="term" value="P:negative regulation of telomere maintenance in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904355">
        <property type="term" value="P:positive regulation of telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904358">
        <property type="term" value="P:positive regulation of telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904535">
        <property type="term" value="P:positive regulation of telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043247">
        <property type="term" value="P:telomere maintenance in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17970">
        <property type="entry name" value="DEAHc_FancJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13932">
        <property type="entry name" value="HN_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.20:FF:000006">
        <property type="entry name" value="Regulator of telomere elongation helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000431">
        <property type="entry name" value="Regulator of telomere elongation helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000691">
        <property type="entry name" value="Regulator of telomere elongation helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03065">
        <property type="entry name" value="RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
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    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
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    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030845">
        <property type="entry name" value="RTEL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049909">
        <property type="entry name" value="Rtel1_HHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23116">
        <property type="entry name" value="HHD_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 16" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0408">Iron</keyword>
    <keyword evidence="10 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="7"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1174"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1205"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1013"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1205"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1298" mass="145384" checksum="1BAE350D86DACB05" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I438</accession>
    <name>A0A670I438_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Vacuolar proton pump subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ATP6V1H</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Clathrin-coated vesicle membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I438"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007113.1">
        <property type="protein sequence ID" value="ENSPMRP00000006678.1"/>
        <property type="gene ID" value="ENSPMRG00000004521.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003289"/>
    <dbReference type="OMA" id="HSGHLRW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00256">
        <property type="entry name" value="VATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000067">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="10">
        <location>
            <begin position="342"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="534" mass="61787" checksum="4FF06A03C145CC8F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4B6</accession>
    <name>A0A670I4B6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I4B6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007183.1">
        <property type="protein sequence ID" value="ENSPMRP00000006746.1"/>
        <property type="gene ID" value="ENSPMRG00000004576.1"/>
    </dbReference>
    <dbReference type="OMA" id="NQHGQIR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39313">
        <property type="entry name" value="IM:7138239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39313:SF1">
        <property type="entry name" value="IM:7138239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="186" mass="20650" checksum="331A15A10A3B352F" modified="2020-06-17" version="1">LPLLSSSCSSFQLQERFPSSLAGSEPSTRLEHSCPANYRCEPSSVRVQELLLLEGVRQVEVIEGCQCNASPSECLRLPSLKTFFPDSPLEQTLDVGRCSNPEHPGEGLFCLPMDFDSILIKTPNGHRSVQIVGSCRLREPCYRVSHMEYYYEVVLNSAGEKLELIKEIDVGRCLGQCDPGSPCLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5N5</accession>
    <name>A0A670I5N5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP-type and C3HC4-type zinc finger-containing protein 1</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase HOIL-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme 7-interacting protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">RBCK1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028591394.1">
        <property type="nucleotide sequence ID" value="XM_028735561.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591395.1">
        <property type="nucleotide sequence ID" value="XM_028735562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I5N5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007476.1">
        <property type="protein sequence ID" value="ENSPMRP00000006989.1"/>
        <property type="gene ID" value="ENSPMRG00000004760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599814"/>
    <dbReference type="CTD" id="10616"/>
    <dbReference type="GeneTree" id="ENSGT00940000161130"/>
    <dbReference type="OMA" id="CRCRMNG"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060546">
        <property type="term" value="P:negative regulation of necroptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20345">
        <property type="entry name" value="BRcat_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16633">
        <property type="entry name" value="mRING-HC-C3HC3D_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20358">
        <property type="entry name" value="Rcat_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01799">
        <property type="entry name" value="Ubl_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000007">
        <property type="entry name" value="RanBP-type and C3HC4-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000140">
        <property type="entry name" value="RanBP-type and C3HC4-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000137">
        <property type="entry name" value="RanBP-type and C3HC4-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000012">
        <property type="entry name" value="ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047558">
        <property type="entry name" value="BRcat_RBR_HOIL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057468">
        <property type="entry name" value="HOIL-1/Sharpin_LTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047559">
        <property type="entry name" value="HOIL1_RBR_mRING-HC-C3HC3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047557">
        <property type="entry name" value="Rcat_RBR_HOIL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF35">
        <property type="entry name" value="RANBP-TYPE AND C3HC4-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25393">
        <property type="entry name" value="LTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="21">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="285"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="289"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="517" mass="58032" checksum="793DAE42D046665D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I796</accession>
    <name>A0A670I796_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SUMO specific peptidase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SENP5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587514.1">
        <property type="nucleotide sequence ID" value="XM_028731681.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028587515.1">
        <property type="nucleotide sequence ID" value="XM_028731682.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028587516.1">
        <property type="nucleotide sequence ID" value="XM_028731683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I796"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008103.1">
        <property type="protein sequence ID" value="ENSPMRP00000007567.1"/>
        <property type="gene ID" value="ENSPMRG00000005104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598046"/>
    <dbReference type="KEGG" id="pmua:114598046"/>
    <dbReference type="CTD" id="205564"/>
    <dbReference type="GeneTree" id="ENSGT00940000159865"/>
    <dbReference type="OMA" id="IFISVME"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Putative sentrin-specific protease 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045577">
        <property type="entry name" value="SENP3_5_cons_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF10">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19722">
        <property type="entry name" value="SENP3_5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="9">
        <location>
            <begin position="565"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="753" mass="86116" checksum="8E7C27DBE903418E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I7B1</accession>
    <name>A0A670I7B1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114598048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028587521.1">
        <property type="nucleotide sequence ID" value="XM_028731688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I7B1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008147.1">
        <property type="protein sequence ID" value="ENSPMRP00000007606.1"/>
        <property type="gene ID" value="ENSPMRG00000005136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598048"/>
    <dbReference type="KEGG" id="pmua:114598048"/>
    <dbReference type="GeneTree" id="ENSGT00940000165367"/>
    <dbReference type="OMA" id="FVGYSKW"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF16">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="10"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="489" mass="53535" checksum="ABC74BB212FA2854" modified="2020-06-17" version="1">MDVQRKKKWTNLTIGLLFLSGGIEYAVILPTLWAYLQTLNAEPYFLGLGISAFSFAGLITGPLFGYWSDRTHKTKAIILFANLFQIAGNFMYFVGGSKWMLLSGRLVAGVGTGAGASIFGYLSRTTTSQERATVFAAVMACRQAGLLIGPACNLFLRLCNFQVGPFVVDKFTSPGIFMCMVWLLLQIIVATLYYDLPPPPLGHSSKAPAAAVRDAVEEEEEKPLVQHEEAAESSSYGSTSTEHREAVSGDEVRYVPNGHLADEEASLEKTPAYNFSSMTEYLREEVVVLLTAQFITLFNQTALETMVTPITQKFLNFGELENSIMYFLCGVEVIAGFFLVRCLSTRLSDRILLVLGLVICNIACAWCLFFLVRPRGTFTILLTELVVGVFLQVLGLPFVAVSQVSLFSKVTAERTQGFSQGLRRSVGGVATILGPLWAGGLTNNLDIMLGVMMGLLSLLTIMVGLSYAYLVEPPRRYVSSQTSEDECSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I7Y5</accession>
    <name>A0A670I7Y5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
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        <name type="common">Wall lizard</name>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <end position="543"/>
        </location>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="756" mass="84350" checksum="37A709C03A6D7827" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IAB1</accession>
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        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
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    </protein>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
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            <location evidence="2">Chromosome</location>
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        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
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        <property type="gene ID" value="ENSPMRG00000005807.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="103" mass="11160" checksum="CE1CEEFDC7A549BF" modified="2020-06-17" version="1">MAPKPAKPATKEQKNKSARAGLQFPVGRIGRLLRRGRYAERVGVGASVYMAAVLEYLTLAIRSDDELNKLFAHVTIAEGGVLPHINALLLPKKTAPSTVPQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IB80</accession>
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        <submittedName>
            <fullName evidence="22">Disintegrin and metalloproteinase domain-containing protein 9-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="22" type="primary">LOC114597413</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
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                <person name="Brejcha J."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028730031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IB80"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009768.1">
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        <property type="gene ID" value="ENSPMRG00000006144.1"/>
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    <dbReference type="GeneID" id="114597413"/>
    <dbReference type="KEGG" id="pmua:114597413"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
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        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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    <keyword evidence="15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
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    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
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        <location>
            <begin position="215"/>
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        <location>
            <begin position="415"/>
            <end position="501"/>
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        <location>
            <begin position="637"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="727"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="784"/>
            <end position="797"/>
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    <feature type="active site" evidence="16">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009150.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="803" mass="88495" checksum="8A1F3EE0FE9CC6C3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBI9</accession>
    <name>A0A670IBI9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Galactokinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GALK1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
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        <property type="gene ID" value="ENSPMRG00000006054.1"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:galactokinase activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005534">
        <property type="term" value="F:galactose binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019402">
        <property type="term" value="P:galactitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061623">
        <property type="term" value="P:glycolytic process from galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Galactokinase_CS"/>
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        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GalKase_gal_bdg"/>
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        <property type="entry name" value="GHMP_kinases_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
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    </dbReference>
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        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
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        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="9">
        <location>
            <begin position="109"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="10">
        <location>
            <begin position="294"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="389" mass="41830" checksum="534F7233326E8627" modified="2020-06-17" version="1">MESPSGPEQGSLLAAARGAYRTFFGGLDPQIAVSAPGRVNLIGEHTDYNQGFVLPMALQMGTMVVGSPREDGIISIVTTAQGADEPKKVTFPGPMEGATLEPGEPRWANYVKGVIQHYQAGPLPGFNAVIASNVPLGGGLSSSASLEVATYTFLQQLCPDNGDPVTKALVCQKAEHTFAMMPCGIMDQFISVMGKEGHALLIDCRSLETFLVPLDDPDVVVLITNSNVRHTLTGSEYPTRRRQCEEAAKVLGKESLREATMADLEASKALLSELVYRRARHVIGEIERTSRASEALQSKDYKRFGQLMVESHNSLRDDYDVSCPELDELVSFALEIPGVYGSRMTGGGFGGCTVTLLESGVAEKVQKHIKVCDIDTEQCLSQWGGQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBL2</accession>
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            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="346"/>
            <end position="620"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1107" mass="132338" checksum="50D70DFF4100427A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBY6</accession>
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        <recommendedName>
            <fullName evidence="8">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IBY6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009821.1">
        <property type="protein sequence ID" value="ENSPMRP00000009198.1"/>
        <property type="gene ID" value="ENSPMRG00000006176.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183145"/>
    <dbReference type="OMA" id="YCESHAG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Deleted in malignant brain tumors 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF15">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
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        </location>
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        <location>
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            <end position="113"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="103"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="133" mass="14556" checksum="3057EE6C5AEE2D49" modified="2020-06-17" version="1">MWQNLYRANHCKQSFSFVFLEGAVKLVNGRHACEGRVEIFHNGRWGTVCDDLWGMTHAQVVCRKLGCGDAVSALGKAPFGEGTGPILMDDVRCTGNEDSLSQCSHRGWGIHNCVHREDAAVMCSGKLGFLDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IE89</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IE89"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010660.1">
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        <property type="gene ID" value="ENSPMRG00000006696.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000245279"/>
    <dbReference type="OMA" id="NWPISEA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="102" mass="11042" checksum="C1AAEB8B2176C29D" modified="2020-06-17" version="1">MRSAVEMHSKARLWQARTVSGASPTPALAVPLAAAMRMPPRERRSQSQANSSPSWKARKRSRAKAANSGYEKLRPFPSAPLSGTGGTRRRVQEAICAATLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IF04</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PEX10</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase. When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028596772.1">
        <property type="nucleotide sequence ID" value="XM_028740939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IF04"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011244.1">
        <property type="protein sequence ID" value="ENSPMRP00000010540.1"/>
        <property type="gene ID" value="ENSPMRG00000007006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602560"/>
    <dbReference type="KEGG" id="pmua:114602560"/>
    <dbReference type="CTD" id="5192"/>
    <dbReference type="GeneTree" id="ENSGT00510000048446"/>
    <dbReference type="OMA" id="YCDVVQL"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044721">
        <property type="term" value="P:protein import into peroxisome matrix, substrate release"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000332">
        <property type="entry name" value="Peroxisome biogenesis factor 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="353" mass="40616" checksum="80902601E19DAF07" modified="2020-06-17" version="1">MRAPREASVCGSSSGRAGTLLASAAMSPAAVEAGPARLVRSAQKDELYRGALRSGAGAALGGLAGARIWLEWQKEIELFADIAYFTLTTLSGYQTLGEEYVSIIQVDPSRKRVPSVFRRAVLISLHTVFPYLLDKGLVHLEHELQTEPDEMRTLQSRHLRGLWGRTFLWRWLQKWLGGLTEQQRKMLCQVVHFLRQGIPLLRRLHLAIFYMNGIFYHLSKRMAGITYLRYAGLDVDNQHVRSSYRLLGILSVLHLALTVGVHAYSFQQRQRARQEWKVHRNLSYPRTQPEEKFLGRSSRCILCLEERRHATATPCGHLFCWECITEWCNTKAECPLCREKFHPQKLIYLQHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFW8</accession>
    <name>A0A670IFW8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sorting nexin-16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SNX16</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homooligomer. Interacts with EGFR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028592434.1">
        <property type="nucleotide sequence ID" value="XM_028736601.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592435.1">
        <property type="nucleotide sequence ID" value="XM_028736602.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592437.1">
        <property type="nucleotide sequence ID" value="XM_028736604.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592438.1">
        <property type="nucleotide sequence ID" value="XM_028736605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IFW8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011346.1">
        <property type="protein sequence ID" value="ENSPMRP00000010636.1"/>
        <property type="gene ID" value="ENSPMRG00000007074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600465"/>
    <dbReference type="KEGG" id="pmua:114600465"/>
    <dbReference type="CTD" id="64089"/>
    <dbReference type="GeneTree" id="ENSGT00390000005651"/>
    <dbReference type="OMA" id="NWEDRPA"/>
    <dbReference type="OrthoDB" id="76516at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07276">
        <property type="entry name" value="PX_SNX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000011">
        <property type="entry name" value="Putative sorting nexin-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037911">
        <property type="entry name" value="SNX16_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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            <end position="217"/>
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            <begin position="229"/>
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            <begin position="1"/>
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        <location>
            <begin position="13"/>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50195"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010636.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="355" mass="39896" checksum="7FF9CDFF6D60EBC0" modified="2020-06-17" version="1">MATPYVPVPIPIGSSTSFTTNRNQRRSSLGSISTCSDSSKAQLEESSISSFKKRSVPDAIGASSSPCNSPLVRTKFIGTNTSMEYCIQPSEDSEQNINSGSWEDRPATPTILGYEVMEERAKFTVYKILVKKNPEENWVVFRRYTDFSRLNDKLKDMFPGFRLALPPKRWFKDNYNPDFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPGPFDSLEESRAFCETLEETNYRLQKELAEKQKEVEALKKMLNEKEVYIDAIEKQLGDLNLGKVKSRKLSGQESECSGEVESSAIEADQGALEEDNSSEKENRATSWSGSLAENHVPEIEVAEGVRTKISAGLYKTIWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGR1</accession>
    <name>A0A670IGR1_PODMU</name>
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        <submittedName>
            <fullName evidence="8">Catenin beta like 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">CTNNBL1</name>
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    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
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    </dbReference>
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            <end position="277"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="161"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="678" mass="76616" checksum="FB627EF2B70B2C08" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGW7</accession>
    <name>A0A670IGW7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 30">Flavin-containing monooxygenase 5</fullName>
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            <ecNumber evidence="30">1.6.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">FMO5</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="30">Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 30 31">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="30">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 30 31">Belongs to the FMO family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family. FIG1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.8" evidence="30"/>
    <dbReference type="EC" id="1.6.3.1" evidence="30"/>
    <dbReference type="AlphaFoldDB" id="A0A670IGW7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011638.1">
        <property type="protein sequence ID" value="ENSPMRP00000010901.1"/>
        <property type="gene ID" value="ENSPMRG00000007256.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160493"/>
    <dbReference type="OMA" id="CCTGYDI"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090181">
        <property type="term" value="P:regulation of cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000042">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000073">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000409">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="30" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 30 31" id="KW-0274">FAD</keyword>
    <keyword evidence="8 30 31" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 30 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 30 31" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 30" id="KW-0521">NADP</keyword>
    <keyword evidence="14 30 31" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 32" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="533" mass="59976" checksum="7EB03D8E914D3495" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIB1</accession>
    <name>A0A670IIB1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lin-28 homolog B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LIN28B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028578887.1">
        <property type="nucleotide sequence ID" value="XM_028723054.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578888.1">
        <property type="nucleotide sequence ID" value="XM_028723055.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578889.1">
        <property type="nucleotide sequence ID" value="XM_028723056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IIB1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012488.1">
        <property type="protein sequence ID" value="ENSPMRP00000011688.1"/>
        <property type="gene ID" value="ENSPMRG00000007830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593994"/>
    <dbReference type="CTD" id="389421"/>
    <dbReference type="GeneTree" id="ENSGT00940000153295"/>
    <dbReference type="OMA" id="EESRMIP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010587">
        <property type="term" value="P:miRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000632">
        <property type="term" value="P:negative regulation of pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000635">
        <property type="term" value="P:negative regulation of primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000627">
        <property type="term" value="P:positive regulation of miRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050779">
        <property type="term" value="P:RNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000007">
        <property type="entry name" value="Protein lin-28 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000087">
        <property type="entry name" value="Protein lin-28 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CSD"/>
    </dbReference>
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        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="Lin-28_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054081">
        <property type="entry name" value="Lin-28A-like_Znf-CCHC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109">
        <property type="entry name" value="PROTEIN LIN-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109:SF3">
        <property type="entry name" value="PROTEIN LIN-28 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21890">
        <property type="entry name" value="Lin-28A-like_zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CSD" evidence="13">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="256" mass="28436" checksum="264F9F5D0CC7A90C" modified="2020-06-17" version="1">MKSFWEASSSPAGARKGGDEPGKLPEQEEEEEEEEEEESQVLHGTGHCKWFNVRMGFGFISMLNREGSPLETPVDVFVHQSKLYMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGIPCLGSERRPKGKTVQKRKPKGDRCYNCGGLDHHAKECTLPPQPKKCHYCQSIMHMVANCPHKTVLQQPTSYQGRYEADPQPSGAYGYTSPSYSQEGRADVLERSGRSPQEAGASTKLSPSPEEQSRKGPSVQKRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIZ8</accession>
    <name>A0A670IIZ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IIZ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012845.1">
        <property type="protein sequence ID" value="ENSPMRP00000012030.1"/>
        <property type="gene ID" value="ENSPMRG00000008035.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="IHGYTEA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="117"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="572" mass="66159" checksum="D5DEA267C4C264DA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILF3</accession>
    <name>A0A670ILF3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013252.1">
        <property type="protein sequence ID" value="ENSPMRP00000012414.1"/>
        <property type="gene ID" value="ENSPMRG00000008294.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166838"/>
    <dbReference type="OMA" id="ECYLIAS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="471"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1285"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1319"/>
            <end position="1334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1358" mass="151373" checksum="A69F6B151886C098" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IMQ7</accession>
    <name>A0A670IMQ7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HMG box transcription factor BBX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Bobby sox homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">HMG box-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BBX</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that is necessary for cell cycle progression from G1 to S phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IMQ7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013886.1">
        <property type="protein sequence ID" value="ENSPMRP00000013006.1"/>
        <property type="gene ID" value="ENSPMRG00000008691.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158592"/>
    <dbReference type="OMA" id="LAEAKMC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21989">
        <property type="entry name" value="HMG-box_HBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000014">
        <property type="entry name" value="HMG box transcription factor BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049523">
        <property type="entry name" value="BBX_HMG-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019102">
        <property type="entry name" value="TF_HMG_box_BBX_DUF2028"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF10">
        <property type="entry name" value="HMG BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09667">
        <property type="entry name" value="DUF2028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="13">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="474"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="535"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="602"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="663"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="733"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="896" mass="99491" checksum="F810A6A8FB8BB26C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INA2</accession>
    <name>A0A670INA2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin carboxyl-terminal hydrolase 46</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Deubiquitinating enzyme 46</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin thioesterase 46</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-specific-processing protease 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">USP46</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. USP12/USP46 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028599058.1">
        <property type="nucleotide sequence ID" value="XM_028743225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670INA2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014560.1">
        <property type="protein sequence ID" value="ENSPMRP00000013628.1"/>
        <property type="gene ID" value="ENSPMRG00000009137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603850"/>
    <dbReference type="KEGG" id="pmua:114603850"/>
    <dbReference type="CTD" id="64854"/>
    <dbReference type="GeneTree" id="ENSGT00940000153284"/>
    <dbReference type="OMA" id="ANFGNTC"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008343">
        <property type="term" value="P:adult feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001662">
        <property type="term" value="P:behavioral fear response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060013">
        <property type="term" value="P:righting reflex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000003">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF714">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0085">Behavior</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="35"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="366" mass="42491" checksum="F59A195BB6C78480" modified="2020-06-17" version="1">MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLSYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTVADILQEEKKQEKQNGKLKNGNMNEAEENNKQELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSGDAINLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INI7</accession>
    <name>A0A670INI7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phagophore assembly factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PHAF1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670INI7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014092.1">
        <property type="protein sequence ID" value="ENSPMRP00000013201.1"/>
        <property type="gene ID" value="ENSPMRG00000008834.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153528"/>
    <dbReference type="OMA" id="YRKNDQK"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="447" mass="50320" checksum="1926769DC0CFF6D9" modified="2020-06-17" version="1">MEGSNCSNVVTLLCDYWAVPLPGPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLLFDAFNQRLKVIEVYDLTKVKLKYCGVHFNSQAIAPTIEQIDQSFGATHPGVYNSAEQLFHLNFRGLSFSFQLDSWTETPKYEPNFAHGLASLQIPHGATVKRMYIYSGNSLQDTKAPMMPLSCFLGNVYAENVDVLRDGAGPSGLRLRLLTAGCGPGVLADAKMRVFERCVYFGDSCQDVLSTLGSPHKVFYKSEDKMKIHSPSPHKQVPSKCNDYFFNYFTLGVDILFDANTHKVKKFVLHTNYPGHYNFNIYHRCEFKIPLAIKRDSTDSQTETCTTYSKWDNIQDLLGHPVEKPVVLHRSSSPNNTNPFGSTFCFGLQRMIFEVMQNNHIASVTLYGPARPSSQLKMSDLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQ28</accession>
    <name>A0A670IQ28_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Matrix metallopeptidase 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">MMP20</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IQ28"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015220.1">
        <property type="protein sequence ID" value="ENSPMRP00000014248.1"/>
        <property type="gene ID" value="ENSPMRG00000009495.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161277"/>
    <dbReference type="OMA" id="YKNPYGF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097186">
        <property type="term" value="P:amelogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000007">
        <property type="entry name" value="Collagenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000002">
        <property type="entry name" value="Matrix metallopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF125">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
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        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
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    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="14 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025588895" evidence="21">
        <location>
            <begin position="23"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="22">
        <location>
            <begin position="112"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="295"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="346"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="393"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="442"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="19">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="17">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="175"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="177"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
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            <label>3</label>
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            <label>3</label>
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        <location>
            <position position="190"/>
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            <name>Zn(2+)</name>
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            <label>1</label>
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        <location>
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            <name>Ca(2+)</name>
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            <label>2</label>
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        <location>
            <position position="203"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
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            <name>Zn(2+)</name>
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            <name>Zn(2+)</name>
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            <name>Ca(2+)</name>
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            <label>4</label>
        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>5</label>
        </ligand>
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        <location>
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            <name>Ca(2+)</name>
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            <name>Ca(2+)</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="298"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023049"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023145"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-3"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00235"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="485" mass="54308" checksum="FB928D596CCB52C1" modified="2020-06-17" version="1">MELCWMLCPLWFLVLSLTYSAAAPALFALPRTAGWKDFYLAQEYLDKYYTPKGEHHVGEMTSGSNSMTRKVQQMQAFFGLRVTGKLDYSTMGVMKRPRCGVPDVANYRLFPGEPKWKRSTLTYRVTKYTSSLSHADVDKAVEMGLKAWSAAAPLNFVKATSGEADIMISFQSGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGMNGFNLFTVAAHEFGHALGLAHSADPSALMYPTYRYQHPYGFHLPKDDVKGIQALYGSRLSGSKVPQVPHPPLPKPPTPADPDHCDATFSFDAVTMLGKELLFFKDRLFWRRQAQLKSSVQPLSITSSFPQLMSNVDAAYEVADRGVAYFFKGPHYWTTRGFQMQGSPRAIADFGFPRNVLQIDAAVYLRDEKKTLFFVGDDYYSYDEAKRKMEKDFPKSIEDEFSGISGRIDAAVEVNGHIYFFSGPKAYKYDKEKEDVVNIVKSSSWVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQ46</accession>
    <name>A0A670IQ46_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 300</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CFAP300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFAP300 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028581974.1">
        <property type="nucleotide sequence ID" value="XM_028726141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IQ46"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015081.1">
        <property type="protein sequence ID" value="ENSPMRP00000014115.1"/>
        <property type="gene ID" value="ENSPMRG00000009428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595656"/>
    <dbReference type="KEGG" id="pmua:114595656"/>
    <dbReference type="CTD" id="85016"/>
    <dbReference type="GeneTree" id="ENSGT00510000047559"/>
    <dbReference type="OMA" id="FYHCYGV"/>
    <dbReference type="OrthoDB" id="10259249at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029416">
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00009205"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="268" mass="31139" checksum="6710CC7BE98C1F6E" modified="2020-06-17" version="1">MAAYGEEGGEPRYAFHHLPQKSFPVLESRDTRDRLLKWSMDGRIAAQAFSFDQNFKGYQRDDFIMAFFNHPDVNSNLKLISPSGQWTTLDTSVRKIDVKNILCKQVSMSFFDRLYCKGVVRESGSIVKCFDEYHDDILIADELRKVLLLEDSDHYDLFSHLDREEFLFCLFKHLCLGGALCQYEDELGPYLETTKALYKELVSVQKDPETKEIKIISTIFKVCAYDAHGLCYPSSNIHEQNFAYLIVNPLKRHIYVLYHSFGEACFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IR79</accession>
    <name>A0A670IR79_PODMU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IR79"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015501.1">
        <property type="protein sequence ID" value="ENSPMRP00000014510.1"/>
        <property type="gene ID" value="ENSPMRG00000009674.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="67" mass="7474" checksum="16874B32C4E51B8C" modified="2020-06-17" version="1">ILSTTRMHLKHMMTLVVQQPVGMSDICCPYLLSNCALYSAEGGSTPLKECKKRIRKFSGSFFACKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISS8</accession>
    <name>A0A670ISS8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Growth hormone-releasing hormone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Growth hormone-releasing factor receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114607890</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028607395.1">
        <property type="nucleotide sequence ID" value="XM_028751562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ISS8"/>
    <dbReference type="SMR" id="A0A670ISS8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016243.1">
        <property type="protein sequence ID" value="ENSPMRP00000015203.1"/>
        <property type="gene ID" value="ENSPMRG00000010142.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607890"/>
    <dbReference type="KEGG" id="pmua:114607890"/>
    <dbReference type="GeneTree" id="ENSGT00940000166678"/>
    <dbReference type="OMA" id="LSCWPRA"/>
    <dbReference type="OrthoDB" id="5967113at2759"/>
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        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016520">
        <property type="term" value="F:growth hormone-releasing hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004999">
        <property type="term" value="F:vasoactive intestinal polypeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Growth hormone-releasing hormone receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vasoactive intestinal polypeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001771">
        <property type="entry name" value="GPCR_2_VIP_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF6">
        <property type="entry name" value="GROWTH HORMONE-RELEASING HORMONE-LIKE PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01154">
        <property type="entry name" value="VIP1RECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025614677" description="Growth hormone-releasing hormone receptor" evidence="17">
        <location>
            <begin position="16"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="18">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="125"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="439" mass="50326" checksum="DBDA708A1B35750A" modified="2020-06-17" version="1">MLLTFCSLFFPLVASIHPECRIFQQLMKDESRCLVENETLLSDFKGCSGVWDGLSCWPKATFGETVTLACPGFFEEITSIHGFLHRNCTPGLYWSEPFPPYPVACGFEESFTKGPEDQKSYYSTFWHIYTAGYATSLASLITALLIFTFFRKFHCTRNYIHMHLFVSFVLRAAAVFTKDTILFSDDSMDHCLMSTVACKSAVAFFQFSILANFFWLLVEGMYLQTLLMLTFVSDKQYAWSFILIGWGAPVIITLIWILNRIYRQNTGCWDDDEEIFAVLWIIKGPILLTVIMNFAIFLNVIRILVQKLKSSKTGGRQTRHFVRLAKSTLLLIPLFGAHYIIFAFFPESIGMVARLYIELGLGSFQGFVVALLYCFLNGEVQAEFKKCLRKWHYRHYLSFARVHRSLSRDNSPVNYVTQLSMLDRISPKRGACQNGLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITF1</accession>
    <name>A0A670ITF1_PODMU</name>
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        <submittedName>
            <fullName evidence="4">NXPE family member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114600880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the NXPE family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028737650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ITF1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000015036.1"/>
        <property type="gene ID" value="ENSPMRG00000010034.1"/>
    </dbReference>
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    <dbReference type="OMA" id="MWHSLSC"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NEUREXOPHILIN AND PC-ESTERASE DOMAIN FAMILY, MEMBER 5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="3">
        <location>
            <begin position="315"/>
            <end position="534"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="537" mass="59227" checksum="73E3D4DDE08B215E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUX5</accession>
    <name>A0A670IUX5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Syntaxin 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">STX10</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IUX5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017093.1">
        <property type="protein sequence ID" value="ENSPMRP00000016013.1"/>
        <property type="gene ID" value="ENSPMRG00000010697.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000002">
        <property type="entry name" value="syntaxin-6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="215"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="307" mass="35285" checksum="42D88F4262454EB7" modified="2020-06-17" version="1">MDPIDDIWGPTGGLANLLRLSPACSCRNRAAAMQGRVDVVFSLVVSRLWQEKQYPVPARPPHPCHSLVFVFCREVQKAVNAARGLYQRWCQLLQETQVVSKEEFDWTTNELRNSLRSIDWDLEDLEETICIVESNPRKFKIEPSEVATRRTFVTEMRESVREMRDHISSPAAQAFAERKNREMLVGSREHYGMLDAEDLSTANSHTLEEQQLHQKLIIEEQDEQLELVSGSIRVLKHMSSRVGEELDEQTVMLEDFAHEMDSTHSRMDGVLKKMARVSHMASERRQWCIIGLLLVVMVVVLVLLFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IW64</accession>
    <name>A0A670IW64_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IW64"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017517.1">
        <property type="protein sequence ID" value="ENSPMRP00000016418.1"/>
        <property type="gene ID" value="ENSPMRG00000010953.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166555"/>
    <dbReference type="OMA" id="RIMNFRE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="435"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="664"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="710"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="778" mass="85824" checksum="804B1991C6D871C6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IX58</accession>
    <name>A0A670IX58_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
            <ecNumber evidence="13">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="13">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EC" id="3.1.3.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A670IX58"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016830.1">
        <property type="protein sequence ID" value="ENSPMRP00000015762.1"/>
        <property type="gene ID" value="ENSPMRG00000010528.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064023"/>
    <dbReference type="OMA" id="SHFWTGP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051998">
        <property type="term" value="F:protein carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000002">
        <property type="entry name" value="Acidic residue methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="14">
        <location>
            <begin position="12"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="316" mass="36447" checksum="12BD36AAF767F036" modified="2020-06-17" version="1">MFLSLLFSPPISDYDVFKKEKDHGFFESQEAIIVLSTYLQELLKNIKGLDEKSLKEEFLKLLQVSLWGNKCDLSMSAGADNSQKSDPLLSVEELKPFILVDHMEKLWSLLINKKNMNKQTTRLDIVLDNAGFELTADLILADFLLSSKLATEIHFHGKSIPWYVSDTTRRDLNWTIKQMQAANHKGMSRCGVCWEGYLKNGLWIYHDHLFWTSPHEYCRMAQVAPDLYSELQKSNLIIFKGDLNYRKLIADRKWEFTVPFHQALNNFHPAPLCSLRTLKCDIQVGLKPGQGEQLTKTEHEWMIIGKYGIIQFDAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J227</accession>
    <name>A0A670J227_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cilia and flagella associated protein 144</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFAP144 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J227"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018725.1">
        <property type="protein sequence ID" value="ENSPMRP00000017589.1"/>
        <property type="gene ID" value="ENSPMRG00000011614.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029214">
        <property type="entry name" value="CFAP144"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN FAM183B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33865:SF3">
        <property type="entry name" value="PROTEIN FAM183B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAM183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="112" mass="13204" checksum="E28F783BE8D3E2A8" modified="2020-06-17" version="1">YCLLPIQGTHCFLKLHSHDVIYTITRKPTSWHDNLEEPADAKFLKLIHHAALEPNKKYTEPQTESQEIGWFSSPLISVNRNDNRLYFPSRSTEITRYMAAMWRLKGMTKDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2C8</accession>
    <name>A0A670J2C8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heat shock 70 kDa protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HSPA14</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J2C8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018649.1">
        <property type="protein sequence ID" value="ENSPMRP00000017517.1"/>
        <property type="gene ID" value="ENSPMRG00000011576.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156380"/>
    <dbReference type="OMA" id="GSTCACA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10238">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000013">
        <property type="entry name" value="Heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000008">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000433">
        <property type="entry name" value="Heat shock protein family A (Hsp70) member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042049">
        <property type="entry name" value="HSPA14_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="543" mass="58376" checksum="1BE5E5902B76FB37" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4S4</accession>
    <name>A0A670J4S4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J4S4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019439.1">
        <property type="protein sequence ID" value="ENSPMRP00000018277.1"/>
        <property type="gene ID" value="ENSPMRG00000012031.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286962"/>
    <dbReference type="OMA" id="HAFIFSQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="445" mass="49529" checksum="1B03598A78DE0C0D" modified="2020-06-17" version="1">MANYRPVSNLPFLGKVIERAVAEQLQARLEEADHLDPFQSGFRPHHGTETALVALVDDLRRARDKGESCFLVLLDLSAAFDTIDHNILLDRLQGLGAGGTVIQWFRSFLLGRVQKVVVGDECSDPWALTCGVPQGSILSPMLFNIYMKPLGEIIRGFGLGVHQYADDTQLYLSFKSEPVKAVKVLCECLEAVGGWMAANRLRLNPDKTEVLFLGDRTRAGVEDSLVLNGVTVPLKDQVRSLGVILDSQLSMEAQVKSVSRAAVYQLHLVCRLRPYLPADCLTRVVHALVISRLDYCNALYVGLPLKVTRKLQLIQNAAARLVTGGGRRDHITPVFKDLHWLPVRFRAQFKVLVLTFKALNGLGPVYLKERLHPHHSARTLRSSAEGLLAVPSLREAKLQGTRQRAFSVVAPALWNALPADVKVINNYLTFRRHLKAALFREVFNV</sequence>
</entry>
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J6T9</accession>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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</entry>
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            <taxon>Bifurcata</taxon>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="165" mass="17913" checksum="3D2D69444655C217" modified="2020-06-17" version="1">MAYDRYLAISHPLLYTLLMGRWRQVQLASASWAGGIILACADIHSTEMIVFGTSAVVILTSLAVILASYGLIFFSVLKMHSTTGLRKALSTCVSHLAVVTLFYSTIIAAYVKPPSVTDPDSDKKLAVFYIVVTPLLNPIIYTLRNKDIHAAAVKSPAQKGLGIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J7U4</accession>
    <name>A0A670J7U4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZDHHC2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A670J7U4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020530.1">
        <property type="protein sequence ID" value="ENSPMRP00000019337.1"/>
        <property type="gene ID" value="ENSPMRG00000012621.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153716"/>
    <dbReference type="OMA" id="XAFRSPV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098837">
        <property type="term" value="C:postsynaptic recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019705">
        <property type="term" value="F:protein-cysteine S-myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140439">
        <property type="term" value="F:protein-cysteine S-stearoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099630">
        <property type="term" value="P:postsynaptic neurotransmitter receptor cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903044">
        <property type="term" value="P:protein localization to membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022407">
        <property type="term" value="P:regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="117"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="358" mass="41055" checksum="CC04DD4DA1CC9849" modified="2020-06-17" version="1">GSPDGPPSSVRRSCQWLIYWVPVLFIGSIVAWSYYAYVGQLCLMVCLLAYHLFFAMFVWSYWKTIFTSPMNPSKEYHLTYADKELLDRETRSEILQEVLRRAAKDLPVYTRTMSGAIRYCDRCQLVKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIVATDLQYFIKFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVTKNKSTLEAFRAPVFRHGTDKNGFSLGFDKNLRQVFGDEKKYWLLPVFSSLGDGCSFPTCLVNQDPEQASTPSGHSSSNKNENSHHFPAKPLRDSQSHLLTDSQSWTETSASIENNKSGMTNPALTVENET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J965</accession>
    <name>A0A670J965_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Recombination signal binding protein for immunoglobulin kappa J region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RBPJ</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598955.1">
        <property type="nucleotide sequence ID" value="XM_028743122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J965"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022091.1">
        <property type="protein sequence ID" value="ENSPMRP00000020806.1"/>
        <property type="gene ID" value="ENSPMRG00000013511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603829"/>
    <dbReference type="KEGG" id="pmua:114603829"/>
    <dbReference type="CTD" id="3516"/>
    <dbReference type="GeneTree" id="ENSGT00390000005197"/>
    <dbReference type="OMA" id="QRQDMPH"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002193">
        <property type="term" value="C:MAML1-RBP-Jkappa- ICN1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003176">
        <property type="term" value="P:aortic valve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060844">
        <property type="term" value="P:arterial endothelial cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036302">
        <property type="term" value="P:atrioventricular canal development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009912">
        <property type="term" value="P:auditory receptor cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097101">
        <property type="term" value="P:blood vessel endothelial cell fate specification"/>
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        <property type="term" value="P:blood vessel lumenization"/>
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    </dbReference>
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        <property type="term" value="P:cardiac muscle cell fate commitment"/>
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        <property type="term" value="P:cardiac muscle cell myoblast differentiation"/>
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        <property type="term" value="P:club cell differentiation"/>
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        <property type="term" value="P:defense response to bacterium"/>
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        <property type="term" value="P:epithelial to mesenchymal transition involved in endocardial cushion formation"/>
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    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="12">
        <location>
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    <sequence length="487" mass="54411" checksum="4E8DE73C001041EF" modified="2020-06-17" version="1">MAPVVTGKFGERPQPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVHAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCAESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSLLASNETSTNSEGSYTNISTNPTNVTSSTATVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAJ0</accession>
    <name>A0A670JAJ0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JAJ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022577.1">
        <property type="protein sequence ID" value="ENSPMRP00000021271.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="entry name" value="TEX29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37339">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37339:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15839">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="76" mass="8842" checksum="2312BADADCB89CC6" modified="2020-06-17" version="1">QFLTCSGRTGKDPCLRPQRAATTHYGCNSFWAFLFSEVCEFPFYEICRENVSRIECSELGCCYHKETCYKKAVPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEM9</accession>
    <name>A0A670JEM9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JEM9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023424.1">
        <property type="protein sequence ID" value="ENSPMRP00000022054.1"/>
        <property type="gene ID" value="ENSPMRG00000014341.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162942"/>
    <dbReference type="OMA" id="RIERGXE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="219" mass="24402" checksum="8A942D6447DB8091" modified="2020-06-17" version="1">EAESRGASVWTLVAAVQAMESKVDALTSRLLSLEGRAGTAEKKIFECEKTELEIGNQLEGKWTVLGTLIQEYGLLQRRLENLENLLKNRNFWILRLPPGVNGEAPKEREKMEDWQKELYKKVLKGNCEYLISLDYAISKPDILSRIERGEDLGPGEQQDADSRENLGDASVAENPLQKQRNHQRSAAPSFVPGDCSKCLGPGVGIFGSLSPLRFCDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEQ8</accession>
    <name>A0A670JEQ8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NHL repeat containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NHLRC4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028561355.1">
        <property type="nucleotide sequence ID" value="XM_028705522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JEQ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024304.1">
        <property type="protein sequence ID" value="ENSPMRP00000022876.1"/>
        <property type="gene ID" value="ENSPMRG00000014848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584060"/>
    <dbReference type="KEGG" id="pmua:114584060"/>
    <dbReference type="CTD" id="283948"/>
    <dbReference type="GeneTree" id="ENSGT00530000063870"/>
    <dbReference type="OMA" id="AESAPWV"/>
    <dbReference type="OrthoDB" id="10020332at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF21">
        <property type="entry name" value="TRIPARTITE MOTIF-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="366" mass="40445" checksum="38F8A5553E743D50" modified="2020-06-17" version="1">MDYTLEDTQRKEKLLRTVYALQVKSDATFQKASPLLNSHPGTGMVTEHQVHQLAEKAKVICHDLDNIKNSLYYRQDELVQQIPNPNGNHYGGVCGIHCSLDGLIYMTSENAPRVHFLNRSGQTFQSIPCVEWKKNETFLPEDVTVTRAGMVAITDLVNGTVRIFNNHSKFSKGEWLRIGKFCSPRGIGVDASGKILVADYTEGKVHSFALDRAFKVQSTHSVSNLRGPRYVCLAPEGGFVVSEECGDVKLFSSNHKLVSSITSKYGHCFGNPSGVCADREGNIIVADEQHQKVHLFPRSGSPICLVSKGLQRPMGIACSTQGLLLVADSGDNYVKVFKYRVRPHYSSDNLCISSDSPNLTPRGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFC1</accession>
    <name>A0A670JFC1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Forkhead box protein J1.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114584237</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FOXJ1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028561732.1">
        <property type="nucleotide sequence ID" value="XM_028705899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JFC1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024557.1">
        <property type="protein sequence ID" value="ENSPMRP00000023121.1"/>
        <property type="gene ID" value="ENSPMRG00000015017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584237"/>
    <dbReference type="KEGG" id="pmua:114584237"/>
    <dbReference type="GeneTree" id="ENSGT00940000164514"/>
    <dbReference type="OMA" id="IYAWITE"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20023">
        <property type="entry name" value="FH_FOXJ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047512">
        <property type="entry name" value="FH_FOXJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047513">
        <property type="entry name" value="FOXJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46805">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46805:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="11">
        <location>
            <begin position="118"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="9">
        <location>
            <begin position="118"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="408" mass="43562" checksum="B476FAD375330914" modified="2020-06-17" version="1">MSLVRPKTGRQQQQQLGAEPWGASCGAGAVDDSLTNLQWLQGFSFLPASPEKPSSARLLGPPRLLQQGSYAPASPPAGDTAAMGAPTGMGKPASSSSSLQPLAPDPEAVDYRTNGQVKPPYSYATLISMAMRASPEAKLTLSAIYAWITENFCYYRHAEPSWQNSIRHNLSLNKCFQKVARQKDEPGKGGFWRINPQHADRFVDGIFRRRRVPTFPCISATQATPPLPASGAELGCFRGRGRGPLKEDQTPRLPGGQRHPGKCKQQPGQGTSKAVWTGARSPLASVGREGVALPGDLSWASVLEDTFVGSGSSIEDLELTAALGSLAAEEVVLASSDQPVSPLSQEGPPHPVPALVEDLTLYAEPLGQPWGEEEAATEPPLGPPWAFEEEGGTCFVEGFLAEMQPWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JG45</accession>
    <name>A0A670JG45_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bardet-Biedl syndrome 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BBS1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JG45"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024867.1">
        <property type="protein sequence ID" value="ENSPMRP00000023426.1"/>
        <property type="gene ID" value="ENSPMRG00000015200.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005232"/>
    <dbReference type="OMA" id="HADRRHY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
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        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cerebral cortex development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:neuron migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:retina development in camera-type eye"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:sensory perception of smell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:striatum development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021591">
        <property type="term" value="P:ventricular system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="BBS1"/>
    </dbReference>
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        <property type="entry name" value="BBS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056419">
        <property type="entry name" value="GAE_BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23304">
        <property type="entry name" value="GAE_BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bardet-Biedl syndrome 1 N-terminal" evidence="1">
        <location>
            <begin position="50"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Bardet-Biedl syndrome 1 protein GAE" evidence="2">
        <location>
            <begin position="500"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="607" mass="67603" checksum="14F0893FEB8ADE85" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHF1</accession>
    <name>A0A670JHF1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OSBP2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JHF1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025321.1">
        <property type="protein sequence ID" value="ENSPMRP00000023861.1"/>
        <property type="gene ID" value="ENSPMRG00000015377.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157987"/>
    <dbReference type="OMA" id="LPEMKGW"/>
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        <property type="component" value="Chromosome 16"/>
    </dbReference>
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        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097440">
        <property type="term" value="C:apical dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13284">
        <property type="entry name" value="PH_OSBP_ORP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000074">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF194">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="83"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="788" mass="88790" checksum="ECB1607215874F53" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHT3</accession>
    <name>A0A670JHT3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">CD248 molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CD248</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566091.1">
        <property type="nucleotide sequence ID" value="XM_028710258.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="pmua:114586610"/>
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    <dbReference type="GeneTree" id="ENSGT00940000162405"/>
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    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990430">
        <property type="term" value="F:extracellular matrix protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03600">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000406">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
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    </dbReference>
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        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789">
        <property type="entry name" value="CHONDROLECTIN VARIANT CHODLFDELTAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789:SF4">
        <property type="entry name" value="ENDOSIALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025676429" evidence="19">
        <location>
            <begin position="33"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="21">
        <location>
            <begin position="44"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="521"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="723" mass="76686" checksum="D863B27FF80F9E62" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLL7</accession>
    <name>A0A670JLL7_PODMU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JLL7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026856.1">
        <property type="protein sequence ID" value="ENSPMRP00000025301.1"/>
        <property type="gene ID" value="ENSPMRG00000016378.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="111" mass="12573" checksum="EE2E644005C51AA5" modified="2020-06-17" version="1">MSQDVMRTLGWEELSWVGPLLEETGRGKEEGGARNTQHYSVEIWEGSTLQILYLAQQSKMWQGREDTEFTLALQGSPTVELNVHLKPTVSLVVVASTPPPPRQIWVFSIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNU6</accession>
    <name>A0A670JNU6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JNU6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026174.1">
        <property type="protein sequence ID" value="ENSPMRP00000024667.1"/>
        <property type="gene ID" value="ENSPMRG00000015937.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="88" mass="10331" checksum="998BEDADBEE7A676" modified="2020-06-17" version="1">MSRADKMSILSVRSFGAEDKDKQYICARENSFVHDPNVTNKTDVRAQIRLHFRDVNGELVQRSMACTQRERKWNLKLFLPRHETQALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNY3</accession>
    <name>A0A670JNY3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JNY3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026727.1">
        <property type="protein sequence ID" value="ENSPMRP00000025184.1"/>
        <property type="gene ID" value="ENSPMRG00000016293.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000212837"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10515" checksum="438BC24353A77803" modified="2020-06-17" version="1">GGTVSAFARVKPTGDFPQDMIKFGEDNKTMEIYIERDRTKGVVNNKQTDWSFKLDGVLHDAPQDAVYDAVARDLVSQESFSFTVNLLTLHFDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JP56</accession>
    <name>A0A670JP56_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="45">5'-AMP-activated protein kinase catalytic subunit alpha-1</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
            <ecNumber evidence="6">2.7.11.26</ecNumber>
            <ecNumber evidence="5">2.7.11.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="37">Acetyl-CoA carboxylase kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="38">Hydroxymethylglutaryl-CoA reductase kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="46">Tau-protein kinase PRKAA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="50" type="primary">PRKAA1</name>
    </gene>
    <organism evidence="50 51">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="50 51" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="50" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="50" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] + ATP = O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23172"/>
            <dbReference type="Rhea" id="RHEA-COMP:13692"/>
            <dbReference type="Rhea" id="RHEA-COMP:13693"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20333"/>
            <dbReference type="Rhea" id="RHEA-COMP:13722"/>
            <dbReference type="Rhea" id="RHEA-COMP:13723"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12801"/>
            <dbReference type="Rhea" id="RHEA-COMP:13701"/>
            <dbReference type="Rhea" id="RHEA-COMP:13702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53904"/>
            <dbReference type="Rhea" id="RHEA-COMP:13703"/>
            <dbReference type="Rhea" id="RHEA-COMP:13704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="36">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
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    <dbReference type="EC" id="2.7.11.26" evidence="6"/>
    <dbReference type="EC" id="2.7.11.31" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028603984.1">
        <property type="nucleotide sequence ID" value="XM_028748151.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A670JP56"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027249.1">
        <property type="protein sequence ID" value="ENSPMRP00000025670.1"/>
        <property type="gene ID" value="ENSPMRG00000016630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606204"/>
    <dbReference type="KEGG" id="pmua:114606204"/>
    <dbReference type="CTD" id="5562"/>
    <dbReference type="GeneTree" id="ENSGT00940000158865"/>
    <dbReference type="OMA" id="GSWLKMA"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047322">
        <property type="term" value="F:[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140823">
        <property type="term" value="F:histone H2BS36 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061762">
        <property type="term" value="P:CAMKK-AMPK signaling cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071380">
        <property type="term" value="P:cellular response to prostaglandin E stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019395">
        <property type="term" value="P:fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905691">
        <property type="term" value="P:lipid droplet disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0061744">
        <property type="term" value="P:motor behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903944">
        <property type="term" value="P:negative regulation of hepatocyte apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050995">
        <property type="term" value="P:negative regulation of lipid catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050868">
        <property type="term" value="P:negative regulation of T cell activation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002841">
        <property type="term" value="P:negative regulation of T cell mediated immune response to tumor cell"/>
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    </dbReference>
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        <property type="term" value="P:negative regulation of TORC1 signaling"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of tubulin deacetylation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070050">
        <property type="term" value="P:neuron cellular homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904179">
        <property type="term" value="P:positive regulation of adipose tissue development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="term" value="P:positive regulation of mitochondrial transcription"/>
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        <property type="term" value="P:positive regulation of protein targeting to mitochondrion"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048643">
        <property type="term" value="P:positive regulation of skeletal muscle tissue development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050870">
        <property type="term" value="P:positive regulation of T cell activation"/>
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    <dbReference type="GO" id="GO:0002842">
        <property type="term" value="P:positive regulation of T cell mediated immune response to tumor cell"/>
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    </dbReference>
    <dbReference type="GO" id="GO:1904263">
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    <dbReference type="GO" id="GO:0045948">
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        <property type="term" value="P:regulation of vascular permeability"/>
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        <property type="term" value="P:response to hydrogen peroxide"/>
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        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="term" value="P:Wnt signaling pathway"/>
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    </dbReference>
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        <property type="entry name" value="AMPKA1_C"/>
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    </dbReference>
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        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UBA_AID_AAPK1"/>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000014">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.200.20:FF:000136">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMPK_C"/>
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        <property type="entry name" value="AMPKA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="PRKAA1/2_AID"/>
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        <property type="entry name" value="PRKAA1_UBA"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF87">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21147">
        <property type="entry name" value="AMPK_alpha_AID"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20 47" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="25" id="KW-0072">Autophagy</keyword>
    <keyword evidence="29" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="18" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="23" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="30" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="33" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="28" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 47" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="35" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="51" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="24" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="34" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="26" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="32" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="31" id="KW-0804">Transcription</keyword>
    <keyword evidence="27" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="22" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="14" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="49">
        <location>
            <begin position="103"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="48">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="48">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="48">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="48">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="47">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
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    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
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    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
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    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00032270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00032865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00047775"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00048291"/>
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    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00048417"/>
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    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048878"/>
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    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00049758"/>
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    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00049783"/>
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    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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        <source>
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    <sequence length="634" mass="71988" checksum="96F11FBE855BF789" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPP7</accession>
    <name>A0A670JPP7_PODMU</name>
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        <submittedName>
            <fullName evidence="10">Regulator of G protein signaling 12</fullName>
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        <name evidence="10" type="primary">RGS12</name>
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    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Cytoplasm</location>
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    <dbReference type="PROSITE" id="PS50898">
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        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
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        <location>
            <begin position="224"/>
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        <location>
            <begin position="703"/>
            <end position="820"/>
        </location>
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        <location>
            <begin position="944"/>
            <end position="1014"/>
        </location>
    </feature>
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        <location>
            <begin position="1016"/>
            <end position="1086"/>
        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
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    <sequence length="1404" mass="154131" checksum="49DF5280508998D2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <sequence length="365" mass="39179" checksum="21FAD421BFA77A9F" modified="2020-06-17" version="1">MAAEPGRAEAEALGEAEAEAEEEASSAAAAASPTRRLAPPPPASWLSPEVGLAAGLGRRFPAGLEVLDVSGTGLAALGAELLELPRLHTLLAKNNRLGAEGSLPKGLAGAPLARSLRVLNLSGNRFTRVPGALLGLRRLRSLSLGSNRLQGIPPAIQQLSSLEFLYLGGNFITSIPPELANLPLLNYLVLCDNKIQSIPPQLAQLHSLRSLSLHNNLLTYLPREILNLVHLEELSLRGNPLVVRFVRDLTYNPPSLQELAGRTIKTRNVPYVPSDLPGNLLRYLSLASNCPNPKCGGVYFDSCVRQIKFVDFCGKYRLPLMHYLCSPECSSPCSSASQSSTSQSESDSEDEAIVAARRMQKVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JT92</accession>
    <name>A0A670JT92_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NUP107</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
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                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="function">
        <text evidence="16">Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Part of the nuclear pore complex (NPC). Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96; this complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus. Does not interact with TPR. Interacts with ZNF106.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="18">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028602097.1">
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    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000027661.1"/>
        <property type="gene ID" value="ENSPMRG00000017844.1"/>
    </dbReference>
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    <dbReference type="OMA" id="MAHIVLF"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0008585">
        <property type="term" value="P:female gonad development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072006">
        <property type="term" value="P:nephron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.50:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12 18" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="14 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="923" mass="106378" checksum="AD4252C32FF66DEF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTL6</accession>
    <name>A0A670JTL6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oxaloacetate tautomerase FAHD1, mitochondrial</fullName>
            <ecNumber evidence="5">3.7.1.5</ecNumber>
            <ecNumber evidence="2">4.1.1.112</ecNumber>
            <ecNumber evidence="9">5.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Acylpyruvase FAHD1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Fumarylacetoacetate hydrolase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FAHD1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26168"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16854"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19009"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57278"/>
            <dbReference type="EC" id="3.7.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>acetylpyruvate + H2O = acetate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16097"/>
            <dbReference type="ChEBI" id="CHEBI:15360"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate = enol-oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:16021"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17479"/>
            <dbReference type="EC" id="5.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:16023"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.5" evidence="5"/>
    <dbReference type="EC" id="4.1.1.112" evidence="2"/>
    <dbReference type="EC" id="5.3.2.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A670JTL6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029484.1">
        <property type="protein sequence ID" value="ENSPMRP00000027796.1"/>
        <property type="gene ID" value="ENSPMRG00000017946.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160452"/>
    <dbReference type="OMA" id="NCRKVIC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047621">
        <property type="term" value="F:acylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034545">
        <property type="term" value="F:fumarylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="15">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="220" mass="24633" checksum="54CC068886AD626D" modified="2020-06-17" version="1">MTSSKPLARFWEWGKNIICVGRNYAEHAKELKNTLPTEPLFFLKPSSAYVREGSPIIQPYYCNKLHHEVELGVVIGKRAQAVPQKTAMDHVAGYALCLDMTARDTQEECKKKGLPWTMAKGFNTSCPVSDFVPKEKVPDPHQLKIWLKVNGEMRQEGDTSDMIFSIPYIISYISGIVTLEEGDVILTGTPKGVSALQENDEIEAGIQGVLSMRFQVLPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JU32</accession>
    <name>A0A670JU32_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Aminopeptidase NAALADL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">N-acetylated-alpha-linked acidic dipeptidase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">NAALADL1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JU32"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030414.1">
        <property type="protein sequence ID" value="ENSPMRP00000028673.1"/>
        <property type="gene ID" value="ENSPMRG00000018264.1"/>
    </dbReference>
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</entry>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="SPECKLE TARGETED PIP5K1A-REGULATED POLY(A) POLYMERASE"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXL4</accession>
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        </submittedName>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </evidence>
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        <source>
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    <sequence length="420" mass="47253" checksum="887DFC3FBE3228FD" modified="2020-06-17" version="1">MSFYSRPRSGSLSAASGRFYPASSAGSVRGSSSGSDSWFSLSRLHAALPAARASADVAPAWLGPGRQQEALQGLNERLAGYLQRVRGLEVANRALEEEIAAIRARKAGAIGQKDWEACERPLAELRKQVEDLNLDNVKLLLQIDNARLAADDFKHKLDAEQAMCDSVQKDTHGLRKMIDDTNYSRLKLEGELESLREELAHLRKSHHEEVEALNALIAKSDITVQVDNPQKHDLSETIAEIRNQYEKMAEQSRSEAEDLYKTKFDSMSQEADVHAQALEEAKSELTELRRQLQGIEIERQTLQKTIDTLENTLKNTGEHYQNEMTNLNHIIAKLQDELAACRADLERQARDYEALLDLKTKLENEIEHYRSLIEGATDRGELQNSGKADTRRQTIKKVVVTTQEIVDGRVVTQRSEEVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYN9</accession>
    <name>A0A670JYN9_PODMU</name>
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            <fullName evidence="7">Small ribosomal subunit protein uS11m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S11, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPS11</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JYN9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032226.1">
        <property type="protein sequence ID" value="ENSPMRP00000030393.1"/>
        <property type="gene ID" value="ENSPMRG00000019651.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 14"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003698">
        <property type="entry name" value="PRK05309.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="186" mass="19742" checksum="99E2DA13521B0BFE" modified="2020-06-17" version="1">RSGFISPLSHDAQRVTWSQSQPLSLAHRVIAGINCGGVLHQNFTFSLPISLFSFYPPAPGKGSTLRWDGKKFEEIPIAHIKATYNNTHILITSHENVALTLSTCGSEGFKSARKATAIAAQTTGIAVAAKASAKGVSHVRVVVKGLGPGRLAAIKGLTMGGLEVISITDDTPIPHNGCRPRKARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0Y0</accession>
    <name>A0A670K0Y0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K0Y0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033061.1">
        <property type="protein sequence ID" value="ENSPMRP00000031168.1"/>
        <property type="gene ID" value="ENSPMRG00000020194.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282779"/>
    <dbReference type="OMA" id="QGETCEW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053311">
        <property type="entry name" value="Mucosal_Integrity_Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37999">
        <property type="entry name" value="MUCIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37999:SF2">
        <property type="entry name" value="MUCIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31882" checksum="81546B4B9455F11B" modified="2020-06-17" version="1">MGQLYKNVDGYRDVVILSVNNGSIDVNFTIIMEINMPNNVSAIDREIVNRTQELVKQLEHANARNCSQQDKDYCFTVLESPALVRNFSAEDYCKNIVKPQYAAYYYANMSTGTLRCITNCTKGTKTSWNCHYGECRIRETGPECLCSDMDKFWYTGDFCETRFQKSEVGLGIGLAILFVTSAVLAFFLFRAMRKKSKESFLDGEELWYVEDEEEEWKPSSGLSIVNKAACEGGLEGRKQVFRPTLDAVDTEMQVCTAIVSSWADFFRLSSPEINRQMMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0Y4</accession>
    <name>A0A670K0Y4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K0Y4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031638.1">
        <property type="protein sequence ID" value="ENSPMRP00000029830.1"/>
        <property type="gene ID" value="ENSPMRG00000019088.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164305"/>
    <dbReference type="OMA" id="PYVINHD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000072">
        <property type="entry name" value="lysosomal alpha-glucosidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF104">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="12">
        <location>
            <begin position="68"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="917" mass="102169" checksum="4571C96AD5BC13A9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K387</accession>
    <name>A0A670K387_PODMU</name>
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            <fullName evidence="2">E3 ubiquitin-protein ligase RNF182</fullName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase RNF182</fullName>
        </alternativeName>
    </protein>
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        <name evidence="11" type="primary">LOC114602303</name>
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    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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            <taxon>Lacertidae</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Interacts with ATP6V0C.</text>
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        <property type="nucleotide sequence ID" value="XM_028740355.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00730000111020"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46675">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF182"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF182"/>
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    </dbReference>
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    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00011482"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031241.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="241" mass="26905" checksum="F27DCE547D3BBD83" modified="2020-06-17" version="1">MNHSQTEGEEKVPNDELECKICYQKFTVQSRKPKILDCLHRVCAKCLTKILHVGDGSHCICCPFCRHKTELQEEEVEGLPDDANIMSKLMTKDKTSWSSDCKEVVLTPKNLASSSPSHGSSNCLVITIMEVQRDSTRTPSQNTLSDYYTDHSLDSASVNSHSHLDQDLFSKLCNHVPRILVWLLGFFYFGSLPLGIYLLVIQKVTLGIVCVSLVPSSLTVCLVYGFCQCLCQGMCDCSSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K403</accession>
    <name>A0A670K403_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L46, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DET1</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K403"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032201.1">
        <property type="protein sequence ID" value="ENSPMRP00000030369.1"/>
        <property type="gene ID" value="ENSPMRG00000019637.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09737">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="561" mass="65571" checksum="3C87F34AA552FB5C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4K0</accession>
    <name>A0A670K4K0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K4K0"/>
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        <property type="protein sequence ID" value="ENSPMRP00000031100.1"/>
        <property type="gene ID" value="ENSPMRG00000020164.1"/>
    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="RT_dom"/>
    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_POL"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="445" mass="49517" checksum="CD469FC34D5AFD42" modified="2020-06-17" version="1">MANYRPVSNLPFLGKVIECVVAEQLQVRLEDVDHLDPFQSGFRPHHGTETALVALVDDLRQARDKGESCFLVLLDLSPAFDTIDHNILLDRLEGLGAGGTVIQWFRSFLLGRVQKVVVGDECSDPWALTCGVPQGSVLSPMLFNIYMKPLGEIIRGFGLGVHQYEDDTQLYLSFKSEPVKAVKVLCECLEAVGGWMAANGLKLNPDKTEVLFLGDRGRAGVEDSLVLNRVTVPLKDQVRSLGVILDSQLSMEAQVNSVSRAAIYQLHLVRRLRPYLPADCLTRVVHALVISRLDYCNALYVGLPLKVTRKLQLFQNAAARLVTGGGRRDHITPVLKDLHWLPVRFRAQFKVLVLTFKALNGLGPVYLKERLHPHHSARTLRSSAEGLLAVPSLREAKLQGTIQKAFSVVGPALWNTLPSDVKAINNYLTFRRHLKAALFREVFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7J8</accession>
    <name>A0A670K7J8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7J8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034222.1">
        <property type="protein sequence ID" value="ENSPMRP00000032270.1"/>
        <property type="gene ID" value="ENSPMRG00000020918.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244869"/>
    <dbReference type="OMA" id="DNITCIT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="111" mass="12672" checksum="EE2FDBE03DABA394" modified="2020-06-17" version="1">MIRNMRNQTEVTEFILLGLSSSPKMRIVLFGIFSVVYSITLAGNGIFLMLIWLDSQLHTPMYFFLSHLSFVDIWYTTSTVPQMLSNLWSPKKTISFAGCGVQTLSRSMTCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7P4</accession>
    <name>A0A670K7P4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cold inducible RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CIRBP</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7P4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032662.1">
        <property type="protein sequence ID" value="ENSPMRP00000030797.1"/>
        <property type="gene ID" value="ENSPMRG00000019955.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153524"/>
    <dbReference type="OMA" id="GWEDRSY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12449">
        <property type="entry name" value="RRM_CIRBP_RBM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000174">
        <property type="entry name" value="cold-inducible RNA-binding protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034278">
        <property type="entry name" value="RBM3/CIRBP_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="246" mass="26281" checksum="B73072C39F77525C" modified="2020-06-17" version="1">MGAADDLIPSRPSRAGAGAILDRAGLICIFMRRAGAQGRYISGGAAEPLRSSRWDFEARNSLAQLGSDFGEKMASDEGKLFVGGLSFDTNEQSLEQVFSKYGQITDVVVVKDRETQRSRGFGFVTFESVDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGAGGDRGYGGSRFESRSGGYGGSRDYYGGSSRSQGSYGDRPSGGSYRDSYDSYATHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K877</accession>
    <name>A0A670K877_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endogenous retrovirus group 3 member 1 Env polyprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC114589763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028572020.1">
        <property type="nucleotide sequence ID" value="XM_028716187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K877"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035834.1">
        <property type="protein sequence ID" value="ENSPMRP00000033783.1"/>
        <property type="gene ID" value="ENSPMRG00000021901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589763"/>
    <dbReference type="KEGG" id="pmua:114589763"/>
    <dbReference type="GeneTree" id="ENSGT00990000212189"/>
    <dbReference type="OrthoDB" id="9909653at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025598247" evidence="1">
        <location>
            <begin position="21"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="337" mass="37150" checksum="2EABC58526612FF8" modified="2020-06-17" version="1">MAQIQLWVPMLVFLLPLTFEIPIPLTVTRQLLQSWGAHHTYNKWIQVAEMVAFSANRTNCAVCTLAPVDALGGMPLLPVPWNESLVTTPLVAFQPLGNHSSLWNHSVPFQVHRITGYLCVNKSNDASDSQTYVGTSHCDRTFPAPTNMFESETGTFSGSNLTTCLARLLRGTISAHGQDVYWVCGRKAYHALPRGWYGVCFPAYLIPPMWIPDQIASAPRRRRRSADLATLAGGSSQNWGKNQWPPERILAHYAPASWNRGEKISGARGPIYNLNRVIRLQAVVEIVANTTATALRLIATQLDGTSVSLSPISVGLSPGATWRLLCSVKSHRWGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KA34</accession>
    <name>A0A670KA34_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL15</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028607046.1">
        <property type="nucleotide sequence ID" value="XM_028751213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KA34"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034413.1">
        <property type="protein sequence ID" value="ENSPMRP00000032454.1"/>
        <property type="gene ID" value="ENSPMRG00000021033.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607775"/>
    <dbReference type="KEGG" id="pmua:114607775"/>
    <dbReference type="CTD" id="6138"/>
    <dbReference type="GeneTree" id="ENSGT00910000144184"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="204" mass="24106" checksum="A6F132211B623F70" modified="2020-06-17" version="1">MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAVRRNPDTQWITKAVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAD0</accession>
    <name>A0A670KAD0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyridine nucleotide-disulphide oxidoreductase dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavin monoamine oxidase family. FIG1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KAD0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035325.1">
        <property type="protein sequence ID" value="ENSPMRP00000033300.1"/>
        <property type="gene ID" value="ENSPMRG00000021588.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156986"/>
    <dbReference type="OMA" id="DYRINFE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF5">
        <property type="entry name" value="GLUTATHIONE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="10">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="174" mass="18644" checksum="9E42725283872C0F" modified="2020-06-17" version="1">GKTPRIYAVGDVCGKAFLTPVAIAAGRKLAHTIFDRKEDSQLDYTNIHIVVFSHPPTGTVGLTEAEARTTYGSESVKTYTTSFIPMYHAVTKKKTKCVMKLVCATKQEKVVGLHMQGLGCDEMLQGFAVAVKMGGTKADFDQTVAIHPTSSEELITLLGIYAKCLSVPNATGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAL2</accession>
    <name>A0A670KAL2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 20" type="primary">LONP1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 15 16">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A670KAL2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035884.1">
        <property type="protein sequence ID" value="ENSPMRP00000033831.1"/>
        <property type="gene ID" value="ENSPMRG00000021946.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063553"/>
    <dbReference type="OMA" id="WLTNIPW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000043">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000002">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000004">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="19">
        <location>
            <begin position="120"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="18">
        <location>
            <begin position="753"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 13 15">
        <location>
            <position position="846"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 13 15">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="517"/>
            <end position="524"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="948" mass="104739" checksum="37A9D04D4C13F00A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAN1</accession>
    <name>A0A670KAN1_PODMU</name>
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        <recommendedName>
            <fullName evidence="6">Beta-glucuronidase</fullName>
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    </protein>
    <gene>
        <name evidence="15" type="primary">GUSB</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the degradation of dermatan and keratan sulfates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
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        <property type="term" value="C:lysosomal lumen"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:signaling receptor binding"/>
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        <property type="term" value="P:articular cartilage development"/>
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        <property type="term" value="P:autophagy"/>
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        <property type="term" value="P:cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:phosphatidylinositol-3-phosphate biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein localization to nucleus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:response to peptide hormone"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
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    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="Glyco_hydro_2"/>
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        <property type="entry name" value="Glyco_hydro_2_AS"/>
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    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="PRK10150.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025509970" description="Beta-glucuronidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="664"/>
        </location>
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        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="13">
        <location>
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        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031842.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="664" mass="75619" checksum="C17B63E2B9561C1C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBN8</accession>
    <name>A0A670KBN8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DCTN6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028568595.1">
        <property type="nucleotide sequence ID" value="XM_028712762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KBN8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035821.1">
        <property type="protein sequence ID" value="ENSPMRP00000033770.1"/>
        <property type="gene ID" value="ENSPMRG00000021890.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587901"/>
    <dbReference type="KEGG" id="pmua:114587901"/>
    <dbReference type="CTD" id="10671"/>
    <dbReference type="GeneTree" id="ENSGT00390000017890"/>
    <dbReference type="OMA" id="ITMQAET"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="197" mass="21418" checksum="604AEBD704AA8DB1" modified="2020-06-17" version="1">MDERADKMAEKAQKSVKIAPGAVVCVESEIKGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQAIIINGYPENITPDTEEVGAKPMIIGTNNVFEVGCYSQAMKIGDNNVIESKAFVGRNVILTSGCIIGACCNVNTYEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKAMKPTSTPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDA5</accession>
    <name>A0A670KDA5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">WD repeat-containing protein 76</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">WDR76</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CUL4A and/or CUL4B.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KDA5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034776.1">
        <property type="protein sequence ID" value="ENSPMRP00000032797.1"/>
        <property type="gene ID" value="ENSPMRG00000021251.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048144"/>
    <dbReference type="OMA" id="DPNTLYW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000180">
        <property type="entry name" value="WD repeat-containing protein 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="514" mass="57242" checksum="C4384BCA775A552E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDU2</accession>
    <name>A0A670KDU2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KDU2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037688.1">
        <property type="protein sequence ID" value="ENSPMRP00000035553.1"/>
        <property type="gene ID" value="ENSPMRG00000022984.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000209942"/>
    <dbReference type="OMA" id="QQMRTHT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="1">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="108" mass="11732" checksum="A3CED7BB420F133D" modified="2020-06-17" version="1">LQGRLNWGKRLDALPAPGADALASGKYPVALPEKFDGAPASFPMFLAQAKLYIQGRARNFPDDCTKVHFLISLLKDQAAKWALPLLRQDSPLLADYGGFCNLLEAAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KH78</accession>
    <name>A0A670KH78_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MAPK10</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="12"/>
    <dbReference type="RefSeq" id="XP_028599472.1">
        <property type="nucleotide sequence ID" value="XM_028743639.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028599473.1">
        <property type="nucleotide sequence ID" value="XM_028743640.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028599474.1">
        <property type="nucleotide sequence ID" value="XM_028743641.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028599475.1">
        <property type="nucleotide sequence ID" value="XM_028743642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KH78"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036158.1">
        <property type="protein sequence ID" value="ENSPMRP00000034092.1"/>
        <property type="gene ID" value="ENSPMRG00000022109.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603995"/>
    <dbReference type="KEGG" id="pmua:114603995"/>
    <dbReference type="CTD" id="5602"/>
    <dbReference type="GeneTree" id="ENSGT00940000153692"/>
    <dbReference type="OMA" id="QGHAFES"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07850">
        <property type="entry name" value="STKc_JNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000009">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="64"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="405"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="464" mass="52596" checksum="2CAF1163A4C8AB41" modified="2020-06-17" version="1">MSRHFLYYCSEPTLDVKIAFCQGFGKQVDVSYIAKYYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDEALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIL2</accession>
    <name>A0A670KIL2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KIL2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037606.1">
        <property type="protein sequence ID" value="ENSPMRP00000035474.1"/>
        <property type="gene ID" value="ENSPMRG00000022948.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271821"/>
    <dbReference type="OMA" id="AHERVIM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025391463" description="Reverse transcriptase zinc-binding domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="38551" checksum="811EB5EF3187AE95" modified="2020-06-17" version="1">MNILPKLLFLFQMIPIIGKDDCFKKWKTDLTKFIWQGKKPRIKHKLLTGIKERGGFGLPDLRLYYDVACFTWIKDWIKLDNSDILDLEEWNNRYGCIITKLKKNISKMYNLLLEWELKDEKVKEVMIKWACDIGYVIRLEQWEKLWKDIKFTACYTIRENFMKMVYQWYLTPVKFAKIYKLKSNTCWRCKKEIGTMFHMWWECRPIKQFWNEIYEELKKMFKISFSKKPEAFLLGLITNDIPENQRKVFHYAITAARMLIAKNWKGRKIPSVKDWQIKFCEYINLARLTAYIREQSDQKLLKEWGCAKEYMKNIVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIM9</accession>
    <name>A0A670KIM9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRK SH3-binding GNRP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RAPGEF1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KIM9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037621.1">
        <property type="protein sequence ID" value="ENSPMRP00000035489.1"/>
        <property type="gene ID" value="ENSPMRG00000022822.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156235"/>
    <dbReference type="OMA" id="INRQEDF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001568">
        <property type="term" value="P:blood vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:platelet-derived growth factor receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="rap guanine nucleotide exchange factor 1"/>
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        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
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        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
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        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
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    </dbReference>
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        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00617">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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    <feature type="chain" id="PRO_5025437933" description="CRK SH3-binding GNRP" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1049"/>
        </location>
    </feature>
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        <location>
            <begin position="663"/>
            <end position="789"/>
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            <begin position="813"/>
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        <location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00083313"/>
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    <sequence length="1049" mass="116483" checksum="E08DA55F9F0A2B7B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJ84</accession>
    <name>A0A670KJ84_PODMU</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="6" type="primary">LOC114605228</name>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2 4">Belongs to the perilipin family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of triglyceride storage"/>
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        <property type="entry name" value="Flagellar protein FliS"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="428" mass="46717" checksum="E97D2DF9F48BFC07" modified="2020-06-17" version="1">MSSNSQGNMSSRDKVQEASAQEENVLRRVVSMPLVSSACDMAANAYNSTKGSHPYVKSVCDAAEKGMKTLKEVAVSTAQPILTKLEPQIAAANEYASRGLDALEEKLPILQMSADKVASDTKEMVSSKVASAKDAIAGKLSGVVGMTKEAVQDGVEATKSAIGQSLTTVMESRMGQIAVSGAEAMLGRSEDLIDEYLPITDEELAEITAAAKDGNVVPVQQCEQQEYLVRLGSLSSRLRQRAYLHAVAKIRRARQRIHESLSQLQQIIHMIEYMKQGVGQTFHEGEKKLSQMLIEWNKANPEAKDNKDMAQLEVESQTLTMFQYLIHRLQTVSQTLVSSIQGFPSSLEDKVQKVGQSTGELHAAASTVRSFQDLPSTLLAQSRQTVQKAQEYMDELLEYVTHNTPLSWLVGPFVLSGKLPAEVSEPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KK95</accession>
    <name>A0A670KK95_PODMU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KK95"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038935.1">
        <property type="protein sequence ID" value="ENSPMRP00000036765.1"/>
        <property type="gene ID" value="ENSPMRG00000023679.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="122" mass="13946" checksum="39F34051B5DB57F1" modified="2020-06-17" version="1">MKTAVTGPKELLSMRGWNRKADLCHRCSSYVLQRVQKLQWVQNAAVRLLTGSSLWDHIHSVLYQLHWLPVEYRIRFKVLVLTFKALCSLGPSFLRDRLSAGDRLVGCPQPTSRYGKTSLPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HLB9</accession>
    <name>A0A670HLB9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD and ring finger domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PHRF1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
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</entry>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="ENSPMRP00000002162.1"/>
        <property type="gene ID" value="ENSPMRG00000001584.1"/>
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        <property type="entry name" value="Uncharacterized protein"/>
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    </dbReference>
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        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
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        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
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        <property type="entry name" value="Znf_BED"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
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        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="12">
        <location>
            <begin position="131"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="451"/>
            <end position="529"/>
        </location>
    </feature>
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        <location>
            <begin position="649"/>
            <end position="721"/>
        </location>
    </feature>
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        <location>
            <begin position="104"/>
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        </location>
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        <location>
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        </location>
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        <location>
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        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50804"/>
        </source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002162.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="79966" checksum="66D53F90F3AFC4E2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HSY9</accession>
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        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:immune system process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_sub"/>
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    </dbReference>
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        <location>
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        </location>
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        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="128" mass="14499" checksum="3545B800FEEE0FA3" modified="2020-06-17" version="1">IKRKDIISLLLGLVTSTSGVEVTQHPTLANKRQGETLELSCDVHQKTYHYYWYRQLPGEINLEHLGTIPKNDLNSRLSGKRVGTKVYLYLESLQLTDSGQYLCTFLVVEALSCLISGRCHFCCLFGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HT14</accession>
    <name>A0A670HT14_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HT14"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002380.1">
        <property type="protein sequence ID" value="ENSPMRP00000002237.1"/>
        <property type="gene ID" value="ENSPMRG00000001626.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="OMA" id="HIVEKHY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <source>
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        <source>
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        <source>
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        <source>
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    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes. Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes glycerol monoesters of long-chain fatty acids.</text>
            <dbReference type="EC" id="3.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. ABHD16 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.23" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028575649.1">
        <property type="nucleotide sequence ID" value="XM_028719816.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000003303.1"/>
        <property type="gene ID" value="ENSPMRG00000002333.1"/>
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    <dbReference type="KEGG" id="pmua:114592012"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905344">
        <property type="term" value="P:prostaglandin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000074">
        <property type="entry name" value="Abhydrolase domain containing 16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054518">
        <property type="entry name" value="ABHD16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF54">
        <property type="entry name" value="PHOSPHATIDYLSERINE LIPASE ABHD16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22990">
        <property type="entry name" value="ABHD16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylserine Lipase ABHD16 N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="15">
        <location>
            <begin position="275"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="552" mass="62829" checksum="330BC8AFF8591A8F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUV0</accession>
    <name>A0A670HUV0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dynein axonemal heavy chain 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Axonemal beta dynein heavy chain 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ciliary dynein heavy chain 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DNAH7</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="16">The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000003067.1">
        <property type="protein sequence ID" value="ENSPMRP00000002862.1"/>
        <property type="gene ID" value="ENSPMRG00000000850.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155282"/>
    <dbReference type="OMA" id="FHDSPYA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="AT13908p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000037">
        <property type="entry name" value="Dynein, axonemal, heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
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    <dbReference type="Gene3D" id="1.10.8.720">
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062885"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071816"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002862.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="3882" mass="445307" checksum="1736CD03E8BDB7C0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWD6</accession>
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        <submittedName>
            <fullName evidence="10">Kinectin 1</fullName>
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        <name evidence="10" type="primary">KTN1</name>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Squamata</taxon>
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            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Bellati A."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
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                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome receptor lysine/proline rich" evidence="9">
        <location>
            <begin position="29"/>
            <end position="147"/>
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    </feature>
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        <location>
            <begin position="40"/>
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05104"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1212" mass="137113" checksum="3E312EBE850FBE21" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWL1</accession>
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        <submittedName>
            <fullName evidence="9">Nebulin related anchoring protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">NRAP</name>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028586062.1">
        <property type="nucleotide sequence ID" value="XM_028730229.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000003482.1"/>
        <property type="gene ID" value="ENSPMRG00000002386.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000158418"/>
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    <dbReference type="OrthoDB" id="9295290at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:fascia adherens"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:muscle tendon junction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:muscle alpha-actinin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:vinculin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cardiac muscle thin filament assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="LIM_N_RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nebulin related anchoring protein"/>
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    </dbReference>
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        <property type="entry name" value="NEBU/NEBL"/>
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        <property type="entry name" value="Nebulin-like"/>
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        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
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        <property type="entry name" value="Znf_LIM"/>
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        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11039:SF39">
        <property type="entry name" value="NEBULIN-RELATED-ANCHORING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00510">
        <property type="entry name" value="NEBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="4"/>
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        <location>
            <begin position="1683"/>
            <end position="1696"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1736" mass="200064" checksum="C54333E82B67FB46" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWT6</accession>
    <name>A0A670HWT6_PODMU</name>
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            <fullName evidence="3">Melanin-concentrating hormone receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">G-protein coupled receptor 24</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">MCH-1R</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114590612</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with NCDN.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000004291.1">
        <property type="protein sequence ID" value="ENSPMRP00000004021.1"/>
        <property type="gene ID" value="ENSPMRG00000002756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114590612"/>
    <dbReference type="KEGG" id="pmua:114590612"/>
    <dbReference type="GeneTree" id="ENSGT00940000154272"/>
    <dbReference type="OMA" id="FTIIPVW"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:melanin-concentrating hormone receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:neuropeptide signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008361">
        <property type="entry name" value="MCH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004047">
        <property type="entry name" value="MCHR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF90">
        <property type="entry name" value="MELANIN-CONCENTRATING HORMONE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01507">
        <property type="entry name" value="MCH1RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01783">
        <property type="entry name" value="MCHRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="51"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032830"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="371" mass="41687" checksum="ADC8831B4ED299B9" modified="2020-06-17" version="1">MAVENCSGASFPMNSSDFPARNRSMVERPTPYTNVIMPSLFGIICFLGIVGNLIVIYTIIKKKKLRCKQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGAWYFGAPLCTIITALDTNSQITSTNILTVMTLDRYLATVYPLKSTYVRTPCVAALVIGLVWLLSLLTIIPVWMYAGLMPLEDGSARCALLLPNPETDIYWFTIYQFMLAFAIPLFIICVVYFKILQHMATTVVPLPQRSLRVRTKKVTRMAVAICSAFFICWAPFYILQLVHLGIDTPSVAFFYAYNFAISLGYANSCLNPFLYIALSETFKRQFMVAIRPAKEQFRVNNNNNSTTEASVCLKLAPESTQQTQFLEDFSPHSLPVTVAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HY27</accession>
    <name>A0A670HY27_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Secreted</location>
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        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
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            <authorList>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
    <dbReference type="InterPro" id="IPR053819">
        <property type="entry name" value="TEADIR3_omega_loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33766:SF1">
        <property type="entry name" value="PROTEIN FAM181A"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="89"/>
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            <end position="106"/>
        </location>
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        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="263" mass="28204" checksum="26EE876B550BC970" modified="2020-06-17" version="1">MASADSEVKTLLNFVNLASSDIKAALDKSAPCRRSVDHRKYLQKQLKRFSQKYSRLPRCHHHHHHLQQQQQQQPQPARERKAPEERARGGLEAPVGRGDRDSKACKAAEPGEQQQGVSEATARPDQVPMRKRQLPASFWEEPRPAPGPLGGNGVAFPAGAASNSSSPSSSSSSSKDLPVLEAKKSKKSPDGGTVSAAESPPGSRPDAEAAQVLSAWSCCPFQYHGPQASPGGAGPKVHRPVVWKPIPTKPAAPPPIFGVFGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ00</accession>
    <name>A0A670HZ00_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BBSome interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HZ00"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004730.1">
        <property type="protein sequence ID" value="ENSPMRP00000004435.1"/>
        <property type="gene ID" value="ENSPMRG00000003031.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235307"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097500">
        <property type="term" value="P:receptor localization to non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028233">
        <property type="entry name" value="BBIP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28596">
        <property type="entry name" value="BBSOME-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28596:SF1">
        <property type="entry name" value="BBSOME-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14777">
        <property type="entry name" value="BBIP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10416" checksum="53E0DF9228BCE554" modified="2020-06-17" version="1">IQLYSNSIRTRAGKGTVWRDGVFVIIFGFSIFLVLGMLAVEDVTTMVLCKPKLLPLKSVTLEKLEKMQREAQETIRQQELLAQQCSNSESIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ01</accession>
    <name>A0A670HZ01_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Receptor-type tyrosine-protein phosphatase kappa</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">PTPRK</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005195.1">
        <property type="protein sequence ID" value="ENSPMRP00000004873.1"/>
        <property type="gene ID" value="ENSPMRG00000003347.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156249"/>
    <dbReference type="OMA" id="RIATKXK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031256">
        <property type="term" value="C:leading edge membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045295">
        <property type="term" value="F:gamma-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048041">
        <property type="term" value="P:focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010839">
        <property type="term" value="P:negative regulation of keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14636">
        <property type="entry name" value="R-PTPc-K-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000003">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase kappa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000005">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase kappa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000019">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase kappa isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000006">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase T isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000009">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000048">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000025">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF209">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025586618" description="Receptor-type tyrosine-protein phosphatase kappa" evidence="20">
        <location>
            <begin position="24"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="23">
        <location>
            <begin position="35"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="197"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="295"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="490"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="21">
        <location>
            <begin position="927"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="22">
        <location>
            <begin position="1107"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="21">
        <location>
            <begin position="1219"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="22">
        <location>
            <begin position="1395"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1485" mass="167296" checksum="64C23DE12599C0C5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZC5</accession>
    <name>A0A670HZC5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ohanin/vespryn family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HZC5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004789.1">
        <property type="protein sequence ID" value="ENSPMRP00000004492.1"/>
        <property type="gene ID" value="ENSPMRG00000003070.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234669"/>
    <dbReference type="OMA" id="RTFHRAR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19762">
        <property type="entry name" value="Bbox2_TRIM7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12888">
        <property type="entry name" value="SPRY_PRY_TRIM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="3"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="385" mass="43301" checksum="4B764D202C7B6493" modified="2025-10-08" version="2">MTPAPLVCEKHQEPLKLFCKEDESPICVVCDRSKEHKSHEVVPLEEASQEYKVGKGSGSFLGVEELLTRGVCDDDDDVMYSLYLLQDLLVSTIREKMVAEFRRLHQFLEEQEKRILAQMAEVEKEIAAKREEHLARLSRELSSLDSLIREMEEKLQEPESELLQVRPGLDARGWSVLLQTTGRSITYLSPHPTPRKEAAVKKHNWYMKGEKPGVTKGVVTLDPDTAHPLLTLSEDRKSVREGGVRQDLPDNPKRFDTCCCVLGGEGFTSGRHFWEVIVGREEGWGVGVARKSVKRKGVLYFNTTEGIWGLGKSDGELKFCSPRKAPVPCEEPERIRVTLNCEGGRVSFYDANTAALLHADTAAPFSGETLQPYFFVSKKGNLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZE0</accession>
    <name>A0A670HZE0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Torsin 1A interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TOR1AIP2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TOR1AIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HZE0"/>
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    <sequence length="393" mass="43883" checksum="E615543D6076AD11" modified="2020-06-17" version="1">MHPRVTRAGRLWPDPAPRYPYRYNNNNNNNNNNNNSLPYTLPNASTQVAAVMAWWVCHVHLTFGQLRCYLPGGRERRMEVRLAKCKLGRRNPGWAWLFRLQHSHLTNTSPLSFPLPPGKQQQHQRQTKARGPDPAQSPSKSSLWMVRFASHGLVLGAVVAFAAVCIGVSGYLTSHPLNVPKNPVVEVFLSRFDPLKDSFPGQRPYLWVRVRKVLQKHLNASRHTEPAILLLASAQEGKATLKCLSSQIADAYSSSLGGSTVQVDGASKSTLSSDRAKAAVVHQFESLPAASTLIFYKYCDHESAAFRDVALILTVLLEDENLEPNVGLQTVEENVRDFLWAKFTDSDMPTSYNHMDTDKLSGLWSRISHLVLPVYPVQAIDDAGNLFSPYMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZI0</accession>
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        <recommendedName>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029343">
        <property type="entry name" value="CCDC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22367">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22367:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15254">
        <property type="entry name" value="CCDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="466"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="944" mass="103534" checksum="610FC17A2344E18B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0C3</accession>
    <name>A0A670I0C3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I0C3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005247.1">
        <property type="protein sequence ID" value="ENSPMRP00000004920.1"/>
        <property type="gene ID" value="ENSPMRG00000003387.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286918"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002281">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002315">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000514">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001297">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000250">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001119">
        <property type="entry name" value="zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000466">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="668" mass="76111" checksum="630C04755731CAF4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0Z9</accession>
    <name>A0A670I0Z9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Docking protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DOK5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOK family. Type B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591073.1">
        <property type="nucleotide sequence ID" value="XM_028735240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I0Z9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005490.1">
        <property type="protein sequence ID" value="ENSPMRP00000005150.1"/>
        <property type="gene ID" value="ENSPMRG00000003538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599656"/>
    <dbReference type="KEGG" id="pmua:114599656"/>
    <dbReference type="CTD" id="55816"/>
    <dbReference type="GeneTree" id="ENSGT00940000160725"/>
    <dbReference type="OMA" id="VKLMVQE"/>
    <dbReference type="OrthoDB" id="6279276at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051386">
        <property type="term" value="P:regulation of neurotrophin TRK receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51064"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    <sequence length="304" mass="35129" checksum="CE5A87C5165292E0" modified="2020-06-17" version="1">MASNFNDIVKQGYVKIRSRRLGIYQKCWLVFKKASSKGPKRIEKFSDERAAYFRCYHKVTELNHVKNILRLPKGTRKHAVGIYFNDDTSRTFACESELEADEWCKVLQVECLGTQINDISLGEPDLLASGVEREQSERFNVYLMPSPNLDVHGECTLQITFENICLWDIQNPRVKLVSWPLSALRRYGRDSTWFTFEAGRMCDTGEGLFIFQTRDGEAIYQKVHSAALTIAEQHDHLLQSVKNSMLQMKMSDRAVSLSTMVPLPRSAYWQHITRQHSTGQLFGLQDSPLKIHRTETFPTYRSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3S4</accession>
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        <name evidence="4" type="primary">LOC114596189</name>
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    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028727431.1"/>
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    </dbReference>
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    </dbReference>
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        <location>
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    </feature>
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            <begin position="39"/>
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    </feature>
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        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="668" mass="74776" checksum="56440488B8CAEBC3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4L5</accession>
    <name>A0A670I4L5_PODMU</name>
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        <recommendedName>
            <fullName evidence="3">uridine/cytidine kinase</fullName>
            <ecNumber evidence="3">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UCKL1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670I4L5"/>
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        <property type="reaction ID" value="UER00637"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001802">
        <property type="entry name" value="Uridine-cytidine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="11">
        <location>
            <begin position="139"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="331"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="549" mass="61275" checksum="C45CE3874F80FFF2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5H4</accession>
    <name>A0A670I5H4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670I5H4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007465.1">
        <property type="protein sequence ID" value="ENSPMRP00000006978.1"/>
        <property type="gene ID" value="ENSPMRG00000004755.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="NTHIYMA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="412" mass="47925" checksum="128429E417B55381" modified="2020-06-17" version="1">MLKILQGRLKQYVDRELPEVQAGFRRGRGTRDQIANMRWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTTDWFKIGKGVRQGCILSPCLFNLYAEFIMRKAGLDESQAGIKIAGRNINNLRYADDTTLMAESEEELKNLLMRVKEESAKYGLKLNIKKTKIMATGPITSWQIEGEEMEAVRDFIFLGSMITADGDSSHEIKRRLLLGRKAMANLDNILKSRDITLPTKVRIVKAMVFPVVMYGSESWTIKKADRRRIDAFELWCWRRLLRVPWTARRSNASILKEIRPECSLEGQIVKLRLQYFGHLMRREDSLEKTLMLGKMEGTRRRGRQRMRWLDSVLEATNMSLTKLREAVEDRSAWRALVHGVTKSRTRLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I7I8</accession>
    <name>A0A670I7I8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LIMS2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I7I8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008304.1">
        <property type="protein sequence ID" value="ENSPMRP00000007760.1"/>
        <property type="gene ID" value="ENSPMRG00000005221.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153518"/>
    <dbReference type="OMA" id="FHEHCFV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990705">
        <property type="term" value="P:cholangiocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904055">
        <property type="term" value="P:negative regulation of cholangiocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000346">
        <property type="term" value="P:negative regulation of hepatocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000178">
        <property type="term" value="P:negative regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061351">
        <property type="term" value="P:neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09331">
        <property type="entry name" value="LIM1_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09332">
        <property type="entry name" value="LIM2_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09333">
        <property type="entry name" value="LIM3_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09334">
        <property type="entry name" value="LIM4_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09335">
        <property type="entry name" value="LIM5_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000011">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000017">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000019">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000021">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000029">
        <property type="entry name" value="LIM and senescent cell antigen-like-containing domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047944">
        <property type="entry name" value="LIMS1/2-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047946">
        <property type="entry name" value="PINCH-1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF10">
        <property type="entry name" value="LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038003">
        <property type="entry name" value="PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="89"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="269"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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    <sequence length="354" mass="40511" checksum="1B5508B882DE555B" modified="2020-06-17" version="1">MASICNCDISFSVLFPSNMSDALANAVCERCRARFDPTERIVNSNGELYHENCFVCAQCFRQFPDGLFYDFEGRKYCEHDFQMLFAPCCGECGEFIIGRVIKAMNNNWHPECFRCELCDVVLADLGFVKNAGRHLCRPCHNREKAKGLGKYICQKCHLIIDEQPLMFRNDSYHPDHFSCTHCGKELTADARELKGELYCLPCHDKMGIPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVNCFACSTCNIKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLSELASKKTHPKALDLNSA</sequence>
</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="While G.M."/>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <sequence length="100" mass="10923" checksum="A4E7572AEFF5606C" modified="2020-06-17" version="1">MIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKVPKSEDIDEEDDDVPDLVENFDEASKNEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9B3</accession>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Chromosome 5"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="LRFN"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR45842:SF25">
        <property type="entry name" value="CARBOXYPEPTIDASE N SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
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        <location>
            <begin position="26"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
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            <end position="458"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
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        </location>
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        </location>
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    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="878" mass="93894" checksum="E38845FF02158FB1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <alternativeName>
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        </alternativeName>
    </protein>
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    </gene>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.5" evidence="3"/>
    <dbReference type="EC" id="3.5.1.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028578590.1">
        <property type="nucleotide sequence ID" value="XM_028722757.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578591.1">
        <property type="nucleotide sequence ID" value="XM_028722758.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578592.1">
        <property type="nucleotide sequence ID" value="XM_028722759.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578593.1">
        <property type="nucleotide sequence ID" value="XM_028722760.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578594.1">
        <property type="nucleotide sequence ID" value="XM_028722761.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578595.1">
        <property type="nucleotide sequence ID" value="XM_028722762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IBW2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009824.1">
        <property type="protein sequence ID" value="ENSPMRP00000009201.1"/>
        <property type="gene ID" value="ENSPMRG00000006179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593869"/>
    <dbReference type="CTD" id="80150"/>
    <dbReference type="GeneTree" id="ENSGT00950000183045"/>
    <dbReference type="OMA" id="MGIIMVD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033345">
        <property type="term" value="P:L-asparagine catabolic process via L-aspartate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04702">
        <property type="entry name" value="ASRGL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000001">
        <property type="entry name" value="Isoaspartyl peptidase/L-asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033844">
        <property type="entry name" value="ASRGL1_meta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF41">
        <property type="entry name" value="ISOASPARTYL PEPTIDASE_L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="16">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="314" mass="32735" checksum="D98A397CFA19770E" modified="2020-06-17" version="1">MKPVIVVHGGAGRIFKDREDGCRSGVTRAALKGYGILKHGGSALDAVEEAVVVMEEDPHFNAGCGSVLNEKGEVEMDAIIMDGKNLASGAVSAVKCIANPIKLARLVMEKTDHMLLTDQGASAFARGMGVPEVPGEKLITGRSLERWKKNLEADSNPQQFQKDLGTVGAVAIDSAGNVACATSTGGLTNKRVGRVGDTACIGSGGYADNNVGATSTTGHGESIMKVVLARLILYHMEQGKSPGDAADSALDCMKTRVGGLGGVIVISNSGDWAARCSTQEMSWATVKDDQLHYGIHAGEWHTQPAEEAISSLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IC70</accession>
    <name>A0A670IC70_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IC70"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009932.1">
        <property type="protein sequence ID" value="ENSPMRP00000009306.1"/>
        <property type="gene ID" value="ENSPMRG00000006263.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="STHICIH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004135">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001661">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000027">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002134">
        <property type="entry name" value="Zinc finger protein 616"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
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        <source>
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    </evidence>
    <sequence length="2963" mass="330368" checksum="87BDF8B5DDE6FFCD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGI5</accession>
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        <recommendedName>
            <fullName evidence="12">Transcription factor HES-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Hairy and enhancer of split 5</fullName>
        </alternativeName>
    </protein>
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        <name evidence="17" type="primary">HES5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="11">Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator.</text>
    </comment>
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        <text evidence="10">Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:glial cell fate commitment"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:S-shaped body morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:specification of loop of Henle identity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:telencephalon development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor HES-5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Orange domain-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="15">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="16">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023791"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00060201"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081413"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="158" mass="17791" checksum="60DE5DA5D08B07B3" modified="2020-06-17" version="1">MATAGASLEIQPSKAKIRLQKPLVEKLRRDRINGSIEQLKLLLEKEFQRHQPSSKLEKADVLEMTVSYLRYSQTLATSSGSRTQDYSKGYSSCLKETLQFLAIHSTNSETQSKLLSHFQKPWEVASKDTSPLSTPALLQKGSPQGAVSKPAYKLWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670II99</accession>
    <name>A0A670II99_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM domain only 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LMO4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670II99"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012470.1">
        <property type="protein sequence ID" value="ENSPMRP00000011673.1"/>
        <property type="gene ID" value="ENSPMRG00000007814.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157730"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09386">
        <property type="entry name" value="LIM1_LMO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09387">
        <property type="entry name" value="LIM2_LMO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF5">
        <property type="entry name" value="LIM DOMAIN TRANSCRIPTION FACTOR LMO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="262"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="326"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="406" mass="43364" checksum="12C17B6CB4853689" modified="2025-10-08" version="2">MGFCSVSNTWARAAERGSEEGASGETEASFARVRRRGSAARGAAEGRERRKEEEAEEAAASSVVAVVSTATAARSGSFAAPLSGLSPCAGRWRREALEAARAPRQGGGGGKGVGGKREPARKCGHICQNLTQLLQQRRQQQPARKEGKEGWSKRFPDISNTTTSSSLPARGCLQFPDPDGGLLLRVARRARWFALRIGPPSIGIEPGQPTSTNPPVSPCESSPEATATLSTASCTIEGKQTMVNPGSSSQPPPVTSGSLSWKRCAGCGGKIADRFLLYAMDSYWHSRCLKCSCCQAQLGEIGTSCYTKSGMILCRNDYIRLFGNSGACSACGQSIPASELVMRAQGNVYHLKCFTCSTCRNRLVPGDRFHYINGSLFCEHDRPTALINGHLNSLQSNPLLPDQKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJT8</accession>
    <name>A0A670IJT8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="9">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EIF5A2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587398.1">
        <property type="nucleotide sequence ID" value="XM_028731565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IJT8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012343.1">
        <property type="protein sequence ID" value="ENSPMRP00000011557.1"/>
        <property type="gene ID" value="ENSPMRG00000007740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597977"/>
    <dbReference type="CTD" id="56648"/>
    <dbReference type="GeneTree" id="ENSGT00390000003738"/>
    <dbReference type="OMA" id="QIMDMET"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0385">Hypusine</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="10">
        <location>
            <begin position="83"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="153" mass="16709" checksum="0302F792036BB5CD" modified="2020-06-17" version="1">MADEVDFTTGDAGASATYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDVFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTESGEVREDLKVPEGELGKEIEGKYNAGEDFQVSVMCAMSEECAVAIKPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IK79</accession>
    <name>A0A670IK79_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IK79"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012875.1">
        <property type="protein sequence ID" value="ENSPMRP00000012061.1"/>
        <property type="gene ID" value="ENSPMRG00000008054.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="RIYREIM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="895" mass="105443" checksum="71C068F23D2A7FBE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKH1</accession>
    <name>A0A670IKH1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HIG1 hypoxia inducible domain family member 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HIGD2A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028574252.1">
        <property type="nucleotide sequence ID" value="XM_028718419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IKH1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012581.1">
        <property type="protein sequence ID" value="ENSPMRP00000011777.1"/>
        <property type="gene ID" value="ENSPMRG00000007881.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591423"/>
    <dbReference type="KEGG" id="pmua:114591423"/>
    <dbReference type="CTD" id="192286"/>
    <dbReference type="GeneTree" id="ENSGT00910000144291"/>
    <dbReference type="OMA" id="FHRGHSQ"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905235">
        <property type="term" value="P:response to quercetin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF18">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="102" mass="11014" checksum="AA67FBF3870D5801" modified="2020-06-17" version="1">MAQSAPPPFDPNNPPLIEGFTPTAYHPEEGFGDKFRRKTRENPLVPIGCLGTAGVLAYGLICFKKGNTLQSQRMMRARVLAQGFTVAAILVGVVVASMKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQE0</accession>
    <name>A0A670IQE0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Sulfatase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SULF2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IQE0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014329.1">
        <property type="protein sequence ID" value="ENSPMRP00000013420.1"/>
        <property type="gene ID" value="ENSPMRG00000008981.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000014341.1">
        <property type="protein sequence ID" value="ENSPMRP00000013432.1"/>
        <property type="gene ID" value="ENSPMRG00000008981.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:Golgi stack"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002063">
        <property type="term" value="P:chondrocyte development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014846">
        <property type="term" value="P:esophagus smooth muscle contraction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035860">
        <property type="term" value="P:glial cell-derived neurotrophic factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032836">
        <property type="term" value="P:glomerular basement membrane development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003094">
        <property type="term" value="P:glomerular filtration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030201">
        <property type="term" value="P:heparan sulfate proteoglycan metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060384">
        <property type="term" value="P:innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097421">
        <property type="term" value="P:liver regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010575">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000345">
        <property type="term" value="P:regulation of hepatocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000003">
        <property type="entry name" value="Extracellular sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014615">
        <property type="entry name" value="Extracellular_sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024609">
        <property type="entry name" value="Extracellular_sulfatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF4">
        <property type="entry name" value="EXTRACELLULAR SULFATASE SULF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12548">
        <property type="entry name" value="DUF3740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036665">
        <property type="entry name" value="Sulf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044625061" evidence="16">
        <location>
            <begin position="25"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="17">
        <location>
            <begin position="44"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Extracellular sulfatase C-terminal" evidence="18">
        <location>
            <begin position="532"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via 3-oxoalanine" evidence="14">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="12">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="828" mass="95657" checksum="AD1A648750D3BC69" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IS24</accession>
    <name>A0A670IS24_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein light chain Tctex-type 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DYNLT4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IS24"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015539.1">
        <property type="protein sequence ID" value="ENSPMRP00000014546.1"/>
        <property type="gene ID" value="ENSPMRG00000009700.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162474"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF55">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="225" mass="24869" checksum="D50E97AFD28E52CB" modified="2020-06-17" version="1">MAERPQVLSQETLNQMMSSEGTDTGHPKAGPLSLPLHSQSTDMAPKPLLRLQSIEEGKAPFPPSRRSSIMSILNAPFPSRRNSLAAGGRRLSIGPWMHCGRVSFSGLPLFEPMREAQYENSYKTKPDEGCKFNASQVQQVLESVLATYLGDAKYNPANGGQVAKNLSDLIRNRIKELIPPRYKLLPHFCRHRICFSKPLMATAPREGMSGHQTKQVALSNAHCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUF4</accession>
    <name>A0A670IUF4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">heme oxygenase (biliverdin-producing)</fullName>
            <ecNumber evidence="3">1.14.14.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HMOX1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heme oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.18" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670IUF4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016181.1">
        <property type="protein sequence ID" value="ENSPMRP00000015144.1"/>
        <property type="gene ID" value="ENSPMRG00000010104.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017673"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071243">
        <property type="term" value="P:cellular response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071276">
        <property type="term" value="P:cellular response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072719">
        <property type="term" value="P:cellular response to cisplatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904019">
        <property type="term" value="P:epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042167">
        <property type="term" value="P:heme catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900016">
        <property type="term" value="P:negative regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110076">
        <property type="term" value="P:negative regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048662">
        <property type="term" value="P:negative regulation of smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903589">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904037">
        <property type="term" value="P:positive regulation of epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048661">
        <property type="term" value="P:positive regulation of smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035094">
        <property type="term" value="P:response to nicotine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002246">
        <property type="term" value="P:wound healing involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000001">
        <property type="entry name" value="Heme oxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018207">
        <property type="entry name" value="Haem_oxygenase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF1">
        <property type="entry name" value="HEME OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00593">
        <property type="entry name" value="HEME_OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="305" mass="35090" checksum="BC404118C3AC7728" modified="2020-06-17" version="1">RAVKICVLGFLDSSTHVLSETKGAHWLPDAKYIGIIFSSPTPLYGQRKTLQLSFSPPFHPLFQLYLASLYYVYVALEKESERNKDNPVYAPVYFPNELNRRAALEEDLEYFYGPTWRKEIQCHEATQKYVDRLHHVGQYEPELLVAHAYTRYLGDLSGGQILKKIAQKMFHLPSTGEGLSFFNFPGVTNISKFKQLYRARMNSLPMDSATEERILEEAKRSFLLNIEVFKELQRLTSQGQTTENLRLEEPKLDLHSRGINRTHSPKESDRVQMGHQQMLPSTPLLRWALAIFFLATTVGVGLYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUP2</accession>
    <name>A0A670IUP2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OTU deubiquitinase with linear linkage specificity like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">OTULINL</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C65 family. Otulin subfamily.</text>
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        <property type="entry name" value="INACTIVE UBIQUITIN THIOESTERASE OTULINL"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00010267"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="320" mass="37898" checksum="B40E27BFA1CFB794" modified="2020-06-17" version="1">MLQPVKGQSALTMTLLATALWCCRQLYTYIAHLLKWWSRYLQRKFTNNQGVSAEADLLGYCAKEWKEETERAKHMRKAYEELFWRHHVKYVRQVRGDNYCVLRAVLFQIFSQGIPLPSWTKATDVLKLPEKLLYSQGCNWIQQYSFGSEQYTGSNTLGKLRRCIEMLRSQWMEVSSIKDPYERGNLCNALFADKSLEHKLYEAIKFIMLYQVIEAYECLNNKQECLPSFFNQLFVRDTSLDPLSYMMNHLNAIGERRGLDQVELFLLGYSLEVKITVYRLCKFNSAVSQESYTDVYQRDWPEVFLLTEDDRHYHIPIIRM</sequence>
</entry>
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        <submittedName>
            <fullName evidence="5">TATA-box binding protein associated factor, RNA polymerase I subunit C</fullName>
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        <name evidence="5" type="primary">TAF1C</name>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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            <taxon>Lacertidae</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSPMRG00000010324.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 11"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TAF1C_HB"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="378"/>
            <end position="515"/>
        </location>
    </feature>
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        <location>
            <begin position="622"/>
            <end position="867"/>
        </location>
    </feature>
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            <begin position="945"/>
            <end position="1014"/>
        </location>
    </feature>
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            <end position="74"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="1014"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20641"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20642"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1014" mass="110545" checksum="6C0F5F319E7F6BCA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVH7</accession>
    <name>A0A670IVH7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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            <taxon>Laterata</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IVH7"/>
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        <property type="protein sequence ID" value="ENSPMRP00000016213.1"/>
        <property type="gene ID" value="ENSPMRG00000010836.1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1121" mass="132643" checksum="860E675BB6A659AF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IY77</accession>
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        <recommendedName>
            <fullName evidence="4">Meckelin-like</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IY77"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017864.1">
        <property type="protein sequence ID" value="ENSPMRP00000016761.1"/>
        <property type="gene ID" value="ENSPMRG00000011151.1"/>
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    <dbReference type="OMA" id="FDLESWM"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019170">
        <property type="entry name" value="Meckelin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21274">
        <property type="entry name" value="MECKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21274:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09773">
        <property type="entry name" value="Meckelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="79157" checksum="AEFAD4766062920D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IYN5</accession>
    <name>A0A670IYN5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cardiotrophin-like cytokine factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">B-cell-stimulating factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Novel neurotrophin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CLCF1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development. Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heteromeric complex with cardiotrophin-like cytokine CRLF1/CLF-1; the CRLF1-CLCF1 complex is a ligand for the ciliary neurotrophic factor receptor/CNTFR. The CRLF1-CLCF1 heterodimer binds SORL1 (via N-terminal ectodomain); within this complex, the interaction is mediated predominantly by the CRLF1 moiety. The tripartite signaling complex formed by CRLF1, CLCF1 and CNTFR also binds SORL1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-6 superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IYN5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018009.1">
        <property type="protein sequence ID" value="ENSPMRP00000016901.1"/>
        <property type="gene ID" value="ENSPMRG00000011218.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ciliary neurotrophic factor receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048711">
        <property type="term" value="P:positive regulation of astrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of isotype switching to IgE isotypes"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="cardiotrophin-like cytokine factor 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010681">
        <property type="entry name" value="PRF/CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21353">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21353:SF7">
        <property type="entry name" value="CARDIOTROPHIN-LIKE CYTOKINE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06875">
        <property type="entry name" value="PRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079727"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="323" mass="36304" checksum="5CD3FFA53EA04DAD" modified="2020-06-17" version="1">MFGNQSATSDWLQEAPAANRKQQKPRQTFGFQKQFANRNSHFQVCSVREPKHLRTKLLMTLAALSTLSLCLLPGNGGVRWEWAMQALLPLSQCSLRPQLLTSVLPAGDSWGILAFLCATLWNLPVVPALNSTDQVTTTRQSIQQTYDLTRYLEHQLHSLAATYLSYLGPPFNEPDFDPPRLIGAEAVPSATVDFQEWHSLNDNARLAANYQAYSHLLCYLSTMDGKSPVAMPTLRHSLAHFRASLQGLLGSIAGIMASLGYQLPPTPTDGTPPLRSQFLRKMDDFWLLKELQTWLWRSAKDFNRLRKRVPPSAVMLHLESRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J078</accession>
    <name>A0A670J078_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Solute carrier family 16 member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SLC16A11</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J078"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019062.1">
        <property type="protein sequence ID" value="ENSPMRP00000017913.1"/>
        <property type="gene ID" value="ENSPMRG00000011818.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162017"/>
    <dbReference type="OMA" id="VEFAIMS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF80">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="359" mass="37473" checksum="869E7C42BAD0FC15" modified="2020-06-17" version="1">MRFGARPVVMLGGLLSSLGVFWASFSTSLLQLYLTLGFLTGFGWALAFAPVMGTLSRYFSSRRSLAMGLALMGNGLSSFAFSPLLRLLADSLAWRGALLATSALGLHLLVCGALLRPLSLRGDLSHSGPGFDLGLFAERGFAAFSLGAALLAAGYFTPYVHLEPYGRAMGLGPYEAAAVVSAASLSDALARLLAGGLADRRLLSPARLLVLCSALTACSLLLFPLASSFADALGLALLYGTSAGSFATVAFGVLPEIVGVSRVVNATGLCLMAMSVGGLLGPPLSGKGHFAYYYYYCLPQFGQTQAGTFENTVPPSCPLPSPSPCALHLSQHQGLFQGVFSSHEVAKVLEPQLQDLSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J092</accession>
    <name>A0A670J092_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ARL1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex. Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The GTP-bound form interacts with GOLGA1. The GTP-bound form interacts with GOLGA4 and RGPD8. The GTP-bound form directly interacts with ARFIP2. Binds to SCOC, preferentially in its GTP-bound form. May interact with UNC119. Interacts with ARFIP1; this interaction directs ARFIP1 to the trans-Golgi membranes. Interacts with ARFGEF1 (via N-terminus).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028601744.1">
        <property type="nucleotide sequence ID" value="XM_028745911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J092"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018686.1">
        <property type="protein sequence ID" value="ENSPMRP00000017551.1"/>
        <property type="gene ID" value="ENSPMRG00000011603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605094"/>
    <dbReference type="KEGG" id="pmua:114605094"/>
    <dbReference type="CTD" id="400"/>
    <dbReference type="GeneTree" id="ENSGT00940000155118"/>
    <dbReference type="OMA" id="MGAGMSW"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990583">
        <property type="term" value="F:phospholipase D activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009404">
        <property type="term" value="P:toxin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="181" mass="20412" checksum="F8892BDA99B5F763" modified="2020-06-17" version="1">MGGFFSTIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELKKAILVVFANKQDMEQAMTPTEMANALGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1N0</accession>
    <name>A0A670J1N0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2 open reading frame 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C2orf42</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J1N0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019567.1">
        <property type="protein sequence ID" value="ENSPMRP00000018403.1"/>
        <property type="gene ID" value="ENSPMRG00000012098.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011031"/>
    <dbReference type="OMA" id="FWMPSQL"/>
    <dbReference type="OrthoDB" id="6506929at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026049">
        <property type="entry name" value="C2orf42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029269">
        <property type="entry name" value="Zf-tcix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13518:SF1">
        <property type="entry name" value="C2ORF42 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13518">
        <property type="entry name" value="PUTATIVE TREBLE-CLEF ZINC-FINGER C2ORF42 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14952">
        <property type="entry name" value="zf-tcix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative treble-clef zinc-finger" evidence="2">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="573" mass="63646" checksum="316D07CCA47BE20C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2E9</accession>
    <name>A0A670J2E9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSPMRP00000017709.1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17375" checksum="54D7617F63690F47" modified="2020-06-17" version="1">MEAVAQYDFQPRNWDELRFRRGDVLKVLERDSEPRWANAERDGREGLIPENRIAFKPHPWFWGKLPRDIADEALARQSFDGAFMIRESESAPGGFSALGTRPTCGRSLTSGLKWRASWASDVEMSFGSWTIRTPTGGKEPAKGGGACCPTTSWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3P9</accession>
    <name>A0A670J3P9_PODMU</name>
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        <recommendedName>
            <fullName evidence="7">Carbonic anhydrase-related protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CA-RP XI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CA11</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Does not have a catalytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J3P9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019323.1">
        <property type="protein sequence ID" value="ENSPMRP00000018164.1"/>
        <property type="gene ID" value="ENSPMRG00000011959.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162098"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03121">
        <property type="entry name" value="alpha_CARP_X_XI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000002">
        <property type="entry name" value="Carbonic anhydrase-related protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041878">
        <property type="entry name" value="Alpha_CARP_X/XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF93">
        <property type="entry name" value="CARBONIC ANHYDRASE-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="328" mass="36815" checksum="8AFD1FF65F0D84BD" modified="2020-06-17" version="1">MVSLKHSPGTISFHLPSAPHGQADESESFPRLLRKDSTGLLVFPLAGPPFWGLVNSAWSLCAIGKRQSPVDVNTSQMVFDPFLPPLRLSTGGKKISGTMYNTGRHVSFRPDPLQLVNVSGGPLLYSHRLQELRLHFGSEDGFGSEHRIDGESFSAEVQLIHYNQELYPNISEASRNPNGLAVISIFIGPSPNPFLTRLLNRETITRISYKNDAYLLHDLSLEDLYPETFGFITYQGSMSTPPCYETATWILIDRPINMTSVQIHSLRLLSQNLPSQIFRSMSDNSRPLQPLLHRSLRGNRDPRRPTRRCKGGNYRLHVDGTRPPKTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5Y3</accession>
    <name>A0A670J5Y3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J5Y3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020165.1">
        <property type="protein sequence ID" value="ENSPMRP00000018989.1"/>
        <property type="gene ID" value="ENSPMRG00000012407.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000174909"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052313">
        <property type="entry name" value="GPIb-IX-V_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22650">
        <property type="entry name" value="GLYCOPROTEIN IB BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22650:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025458278" description="LRRNT domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="11">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="247" mass="26197" checksum="535E0A34C3444318" modified="2020-06-17" version="1">MSPFSVAILLSCALVAQASQACPHPCTCYESSSFVDCHSRHLAQVPPGVPHDTWMLDLRHNNLSGLEGGGFDALMRLALCGITAPWHSLLLTEKVTIGNAYLRWTFSSGLSLELRANISVACFPIESRAVLSMCGARVQISAQRPPLLPSPRRAGGQSRPLASASRWLGCPRTCGVEPPAAEEPATALRPMGRLFPGLNSQAPASRPGAPESPAPGCPAPLAPMGKTALIESKAKQINPFQTFKNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J715</accession>
    <name>A0A670J715_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Midkine</fullName>
            <shortName evidence="10">MK</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MDK</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the pleiotrophin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J715"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020262.1">
        <property type="protein sequence ID" value="ENSPMRP00000019082.1"/>
        <property type="gene ID" value="ENSPMRG00000012465.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007640"/>
    <dbReference type="OMA" id="AECQTTV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035374">
        <property type="term" value="F:chondroitin sulfate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904399">
        <property type="term" value="F:heparan sulfate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001662">
        <property type="term" value="P:behavioral fear response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021681">
        <property type="term" value="P:cerebellar granular layer development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030421">
        <property type="term" value="P:defecation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106091">
        <property type="term" value="P:glial cell projection elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002232">
        <property type="term" value="P:leukocyte chemotaxis involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010667">
        <property type="term" value="P:negative regulation of cardiac muscle cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904036">
        <property type="term" value="P:negative regulation of epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106015">
        <property type="term" value="P:negative regulation of inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030279">
        <property type="term" value="P:negative regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045590">
        <property type="term" value="P:negative regulation of regulatory T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905653">
        <property type="term" value="P:positive regulation of artery morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905555">
        <property type="term" value="P:positive regulation of blood vessel branching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061036">
        <property type="term" value="P:positive regulation of cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010718">
        <property type="term" value="P:positive regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000347">
        <property type="term" value="P:positive regulation of hepatocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106016">
        <property type="term" value="P:positive regulation of inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032735">
        <property type="term" value="P:positive regulation of interleukin-12 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010838">
        <property type="term" value="P:positive regulation of keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904996">
        <property type="term" value="P:positive regulation of leukocyte adhesion to vascular endothelial cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010759">
        <property type="term" value="P:positive regulation of macrophage chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000179">
        <property type="term" value="P:positive regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001224">
        <property type="term" value="P:positive regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090023">
        <property type="term" value="P:positive regulation of neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000391">
        <property type="term" value="P:positive regulation of neutrophil extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048714">
        <property type="term" value="P:positive regulation of oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071673">
        <property type="term" value="P:positive regulation of smooth muscle cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045582">
        <property type="term" value="P:positive regulation of T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905564">
        <property type="term" value="P:positive regulation of vascular endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050795">
        <property type="term" value="P:regulation of behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046850">
        <property type="term" value="P:regulation of bone remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032330">
        <property type="term" value="P:regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010996">
        <property type="term" value="P:response to auditory stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007614">
        <property type="term" value="P:short-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002286">
        <property type="term" value="P:T cell activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.60.10:FF:000002">
        <property type="entry name" value="Midkine a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.90.10:FF:000001">
        <property type="entry name" value="Pleiotrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.90.10">
        <property type="entry name" value="Heparin-binding Growth Factor, Midkine, Chain A- C-terminal Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.60.10">
        <property type="entry name" value="Pleiotrophin/Midkine, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000762">
        <property type="entry name" value="Midkine_heparin-bd_GF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020090">
        <property type="entry name" value="PTN/MK_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038130">
        <property type="entry name" value="PTN/MK_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020091">
        <property type="entry name" value="PTN/MK_diS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020089">
        <property type="entry name" value="PTN/MK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037122">
        <property type="entry name" value="PTN/MK_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020092">
        <property type="entry name" value="PTN_MK_heparin-bd_GF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13850:SF2">
        <property type="entry name" value="MIDKINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13850">
        <property type="entry name" value="PLEIOTROPHIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01091">
        <property type="entry name" value="PTN_MK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05196">
        <property type="entry name" value="PTN_MK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00269">
        <property type="entry name" value="PTNMIDKINE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00193">
        <property type="entry name" value="PTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57288">
        <property type="entry name" value="Midkine"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00619">
        <property type="entry name" value="PTN_MK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00620">
        <property type="entry name" value="PTN_MK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="5 10" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="9 10" id="KW-0497">Mitogen</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025394714" description="Midkine" evidence="10">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Pleiotrophin/Midkine N-terminal" evidence="13">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Pleiotrophin/Midkine C-terminal" evidence="12">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="146" mass="16104" checksum="AB939FFAE03B6334" modified="2020-06-17" version="1">MQVRGLYLLLVLILLAASSEAGKNKKEKVKKNGSDCEEWRWGPCVPNSKDCGVGFREGTCNEETKKLKCKIPCNWKKEFGADCKYKFESWGGCDSATGLKSRSGTLKKALYNAECQETIQVTKPCSPKAKSKSKGESQLLGSLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J9P2</accession>
    <name>A0A670J9P2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acylglycerol lipase</fullName>
            <ecNumber evidence="3">3.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:75539"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes glycerol monoesters of long-chain fatty acids.</text>
            <dbReference type="EC" id="3.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Late endosome membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Lysosome membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.23" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670J9P2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022314.1">
        <property type="protein sequence ID" value="ENSPMRP00000021016.1"/>
        <property type="gene ID" value="ENSPMRG00000013662.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047225"/>
    <dbReference type="OMA" id="QIHTLTM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="281" mass="31817" checksum="88D724D31E65F970" modified="2020-06-17" version="1">MKVKFVEHEGYRFCYFCRGKPGSQPSVLMLHGFSFNKDMWLDTIKLFPKDLHVVCLDMPGHGETIRLLAESYTAVNQAKMIHQFVECIGLNQKPFHLVGMSMGGTIAGIYAAQYPSDVSRLSLLCPPGLRNAADNEFIKRLKELRKSTNSHSNPLVPLTVKQGERQQAWKCSRVKRPQKQASLCFFLGKGFLDMSSKESRYHLHDSMSKIRAPAQIIWGREDKVMDPSGAEMLAKAIPSSQVHMLEKCGHFITLDRPRKLSKLLLEFHYSVCGTAENKKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JA02</accession>
    <name>A0A670JA02_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JA02"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022625.1">
        <property type="protein sequence ID" value="ENSPMRP00000021313.1"/>
        <property type="gene ID" value="ENSPMRG00000013845.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00970000198043"/>
    <dbReference type="OMA" id="FFAMLEM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052873">
        <property type="entry name" value="HEATR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38323">
        <property type="entry name" value="PROTEIN HEATR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38323:SF1">
        <property type="entry name" value="PROTEIN HEATR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22558" checksum="4D9E70414906CECA" modified="2020-06-17" version="1">MLVKQMAIVDPVVIKTVIDQLQRSPLYKHRVDAARLLATIGLEIIQEEGLEEEVFNVLLEKLSEEPFLVVRQAVASTVEELNIKKRVWDIVEKQLRDDKDEIRKKAVIALGVLGIRNKSLFFAMLEMLELDTCEDVRIQVVRAFSTLGMDNMHVRKSLVKKAQTQGILARECSKALESLDKVSDAQKEYMLQSFKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBW4</accession>
    <name>A0A670JBW4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone H3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JBW4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021970.1">
        <property type="protein sequence ID" value="ENSPMRP00000020687.1"/>
        <property type="gene ID" value="ENSPMRG00000013441.1"/>
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    <dbReference type="GeneTree" id="ENSGT01150000286903"/>
    <dbReference type="OMA" id="GERNCPV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000047">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
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    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="4">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="129" mass="14685" checksum="0FCFD71E4670D77B" modified="2020-06-17" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIVCGGGNGHCWLGAWRIGFSRVWQRRPRYPIIVSLYGVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEH0</accession>
    <name>A0A670JEH0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Chromodomain helicase DNA binding protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CHD9</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000023368.1">
        <property type="protein sequence ID" value="ENSPMRP00000021999.1"/>
        <property type="gene ID" value="ENSPMRG00000011919.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155706"/>
    <dbReference type="OMA" id="HIIRGAY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18668">
        <property type="entry name" value="CD1_tandem_CHD5-9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18663">
        <property type="entry name" value="CD2_tandem_CHD5-9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18061">
        <property type="entry name" value="DEXHc_CHD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000001">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 8 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000003">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 8 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.120:FF:000002">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.120:FF:000003">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000015">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006576">
        <property type="entry name" value="BRK_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037259">
        <property type="entry name" value="BRK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051493">
        <property type="entry name" value="CHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056342">
        <property type="entry name" value="HTH_CHD6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07533">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23078">
        <property type="entry name" value="HTH_CHD6-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00592">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160481">
        <property type="entry name" value="BRK domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="15">
        <location>
            <begin position="769"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="868"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1182"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="421"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="530"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1451"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2037"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2300"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2727"/>
            <end position="2770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2816"/>
            <end position="2887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1461"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1471"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2037"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2070"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2081"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2132"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2732"/>
            <end position="2751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2761"/>
            <end position="2770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2816"/>
            <end position="2828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2829"/>
            <end position="2848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2867"/>
            <end position="2878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="2887" mass="324470" checksum="B087B0EE81844B47" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JES5</accession>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSPMRG00000014045.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
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    </dbReference>
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        <property type="entry name" value="RT_POL"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="492"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1060" mass="124464" checksum="11F563D43E0D75B6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JET9</accession>
    <name>A0A670JET9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RAB40C</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028561448.1">
        <property type="nucleotide sequence ID" value="XM_028705615.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000022911.1"/>
        <property type="gene ID" value="ENSPMRG00000014870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584102"/>
    <dbReference type="KEGG" id="pmua:114584102"/>
    <dbReference type="CTD" id="57799"/>
    <dbReference type="GeneTree" id="ENSGT00940000158979"/>
    <dbReference type="OMA" id="HINIGQC"/>
    <dbReference type="OrthoDB" id="6339763at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031466">
        <property type="term" value="C:Cul5-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051895">
        <property type="term" value="P:negative regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051894">
        <property type="term" value="P:positive regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04121">
        <property type="entry name" value="Rab40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03742">
        <property type="entry name" value="SOCS_Rab40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000371">
        <property type="entry name" value="RAB40C, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RAB"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SOCS box" evidence="18">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022911.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="285" mass="31954" checksum="983102F77E17F5C7" modified="2020-06-17" version="1">MRGRMGTQGSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGASESPYAYSNGIDYKTTTILLDGRRVKLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSFDGIDRWIKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARSYAEKNCMTFFEVSPLCNFNVIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTIKSHLKSFSMANGMNAVMMHGRSYSLASSGGGSSSKGNSLKRSKSIRPPQSPPQNCSRNNCKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JF33</accession>
    <name>A0A670JF33_PODMU</name>
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        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JF33"/>
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        <property type="gene ID" value="ENSPMRG00000014750.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000190705"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="152" mass="17546" checksum="B00DFD4EAA9B6A04" modified="2020-06-17" version="1">MLPMSGNPSSHAILNMIFLFLGRSKPIKCSHGWAAYEGHCYRLYRHLKTWPQALSSCRKEGGDLISIHNIEEHSFIISQLGYRKYIQKIWHRLLQPSSAWFHPDVLNYKPYTFQHNQWAGMIGVLFQNIGGYQVSEDANASVILHYVTDTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHN0</accession>
    <name>A0A670JHN0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRAS1 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000025659.1">
        <property type="protein sequence ID" value="ENSPMRP00000024193.1"/>
        <property type="gene ID" value="ENSPMRG00000015533.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165098"/>
    <dbReference type="OMA" id="MPVNDNK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045658">
        <property type="entry name" value="FRAS1-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF3">
        <property type="entry name" value="FRAS-RELATED EXTRACELLULAR MATRIX PROTEIN 1B PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19309">
        <property type="entry name" value="Frem_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025344923" description="C-type lectin domain-containing protein" evidence="11">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
    </reference>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        </subcellularLocation>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    </organism>
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bosakova Z."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RT_POL"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026478.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="562" mass="64302" checksum="2A3BCDEB8D7889D6" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQT9</accession>
    <name>A0A670JQT9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Malectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MLEC</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028564845.1">
        <property type="nucleotide sequence ID" value="XM_028709012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JQT9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027869.1">
        <property type="protein sequence ID" value="ENSPMRP00000026265.1"/>
        <property type="gene ID" value="ENSPMRG00000016994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586082"/>
    <dbReference type="KEGG" id="pmua:114586082"/>
    <dbReference type="CTD" id="9761"/>
    <dbReference type="GeneTree" id="ENSGT00390000016504"/>
    <dbReference type="OMA" id="PNPYSMD"/>
    <dbReference type="OrthoDB" id="10013439at2759"/>
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        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000006">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039155">
        <property type="entry name" value="MLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025595684" evidence="12">
        <location>
            <begin position="42"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="13">
        <location>
            <begin position="51"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="295" mass="32455" checksum="1B40B3268B0600AE" modified="2020-06-17" version="1">MAVVAAVPVAAAGSSGPPLLAASVLLPALMLLLLPPQPPHAVEGAGLTENVIWAVNAGGEAHVDVHGIHFRKDPLEGRVGRASDYGMKLPILRSNPEDQILYQTERYNEETFGYEVPIKEEGDYVLVLKFAEVYFAQSQQKVFDVRLNGHVVVKDLDIFDRVGHSTAHDEIIPIGIKKGKLSVQGEVSTFTGKLNIEFVKGYYDNPKVCALYVLRGTVDDVPKLQPHPGLEKKEEEEDEEEYEEGSSTKKQTNKNRVQSGPRTPNPYASDNSSLMFPILVAFGVFIPTLFCLCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQZ2</accession>
    <name>A0A670JQZ2_PODMU</name>
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        <recommendedName>
            <fullName evidence="22">Acyltransferase</fullName>
            <ecNumber evidence="22">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MOGAT1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 1-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:77559"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:77560"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:39943"/>
            <dbReference type="ChEBI" id="CHEBI:35759"/>
            <dbReference type="ChEBI" id="CHEBI:49172"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:39944"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:77571"/>
            <dbReference type="ChEBI" id="CHEBI:35759"/>
            <dbReference type="ChEBI" id="CHEBI:47777"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:77572"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:32947"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:32948"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:16741"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:49172"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="2.3.1.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:16742"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38467"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:75524"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:38468"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:77555"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64760"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:77556"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Endoplasmic reticulum membrane</location>
            <topology evidence="1 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="22"/>
    <dbReference type="RefSeq" id="XP_028586894.1">
        <property type="nucleotide sequence ID" value="XM_028731061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JQZ2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026954.1">
        <property type="protein sequence ID" value="ENSPMRP00000025392.1"/>
        <property type="gene ID" value="ENSPMRG00000016432.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597794"/>
    <dbReference type="KEGG" id="pmua:114597794"/>
    <dbReference type="CTD" id="116255"/>
    <dbReference type="GeneTree" id="ENSGT01030000234582"/>
    <dbReference type="OMA" id="DTNFRVP"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003846">
        <property type="term" value="F:2-acylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:diacylglycerol biosynthetic process"/>
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        <property type="entry name" value="2-ACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="9 22" id="KW-0256">Endoplasmic reticulum</keyword>
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        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
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            <begin position="105"/>
            <end position="114"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="471" mass="52650" checksum="8853D5D3E6758B13" modified="2020-06-17" version="1">MPSPLPRPQAPPPHEQHRLRGALLGPPPRSATGPRKQRSPCSRPAARADPCSLGAGEGADRGAKLSSRSPTPLAPGIVPAAGPRLGISKLGRGDGLSPLARRRPAREEDPPRGRREAALTVALWAPSGVKPLRRRAMKVEFAPLNIPLARRLQTAAVFQWVFSFLLLAQCCCGIFMIFVFGDYWFISAIYVLWLYLDWETPQTGGRRSKWVRNWTVWRYFKEYFPIQLIKTSDLDPSQNYLFGFHPHGVLVAGAFGNFCTEYTGFKRLFPGLTPYLHILPFWFRCPFFRDYIMCAGLVSASKKSVSHVLSHEGGGNVAVIVIGGAEESLDARPGSLTLSILKRKGFIKVALKHGAQLVPVFSFGENELFKQVANPKGSRLRRLQEKLQKIMGFALPLFHGRGIFQYSFGVMPYRKPVHTIVGNPIAVKQNLNPTVEEINQLHEKYLQELQELFDKNKEKYGISEHASLTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRX2</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Bosakova Z."/>
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                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="122" mass="13785" checksum="2BDC2F30DB23A092" modified="2020-06-17" version="1">VRNPQTGALPIHVLHAYAPTHTCMCCVLTTTTFPVLQRSIGRRLYDEDDDLSDVEEIVSIRGFNLEEKLRSKMYRGDFVRPMEGKGNPGRLSKAWARACKFLFNSEVLCMHPELGLEDASTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A670JUY3_PODMU</name>
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        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Bifurcata</taxon>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A670JVL6_PODMU</name>
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        <recommendedName>
            <fullName evidence="3">Coiled-coil domain containing 87</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JVL6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029651.1">
        <property type="protein sequence ID" value="ENSPMRP00000027955.1"/>
        <property type="gene ID" value="ENSPMRG00000018042.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018647"/>
    <dbReference type="OMA" id="GEWDWNT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037383">
        <property type="entry name" value="CCDC87"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16078">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16078:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="83353" checksum="47CB189D7F339EF1" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWU8</accession>
    <name>A0A670JWU8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SDHAF3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JWU8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029575.1">
        <property type="protein sequence ID" value="ENSPMRP00000027884.1"/>
        <property type="gene ID" value="ENSPMRG00000018004.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010029"/>
    <dbReference type="OMA" id="WQQTNEN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="15185" checksum="EBDDFD571E610752" modified="2020-06-17" version="1">MPGSLNHHVSRVRTLYKKILQLHRALPLELKTLGDQYVKDEFRRHRSVGPEEAQCFLREWENYAATLLQQTNPKAQNSTSHPRFGSHLPEEKLHALRDEQVGQLQELMQEATKPKRHSYIIESMTAQFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JX18</accession>
    <name>A0A670JX18_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Outer mitochondrial transmembrane helix translocase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ATAD1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Postsynaptic cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. MSP1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028564525.1">
        <property type="nucleotide sequence ID" value="XM_028708692.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028564526.1">
        <property type="nucleotide sequence ID" value="XM_028708693.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028564527.1">
        <property type="nucleotide sequence ID" value="XM_028708694.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028564528.1">
        <property type="nucleotide sequence ID" value="XM_028708695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JX18"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028972.1">
        <property type="protein sequence ID" value="ENSPMRP00000027312.1"/>
        <property type="gene ID" value="ENSPMRG00000017622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585808"/>
    <dbReference type="KEGG" id="pmua:114585808"/>
    <dbReference type="CTD" id="84896"/>
    <dbReference type="GeneTree" id="ENSGT00550000074823"/>
    <dbReference type="OMA" id="WSGHADS"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19520">
        <property type="entry name" value="RecA-like_ATAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF8">
        <property type="entry name" value="OUTER MITOCHONDRIAL TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="129"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="381" mass="42878" checksum="136EA1901AC5C139" modified="2020-06-17" version="1">MLLGEVSKDLLTRPLTRNEVFAVLLRLTVFGAATYFSIKWVSDALDPTRKQRIQLKKKAEHLMKQIGVEGVKLAEHEMIIAAHLVVPKDIKVTWKDIAGLDEMVSELQDTVILPFQRRHLLQHSRLCQPPRGVLLYGPPGCGKTLLAKATAQASGCRFINLQASTLTDKWYGESQKLTAAVFSLATKLQPCIIFIDEIDAFLRNRSEADHEATAMMKAEFMSLWDGLETGTNCQVMVLGATNRPQDVDPAILRRMPTTFQIGLPTQRQRQDILKLILAGENMSNAVNLKELAEKTKGYSGSDLRELCRDAAMYRVRDYVRKQQMKQIAWMLHDTDSGEESDLEEERLRPLTQLDLLFALEKMEESKGASTAVPTLEEPALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JY58</accession>
    <name>A0A670JY58_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="10">CPR</shortName>
            <shortName evidence="10">P450R</shortName>
            <ecNumber evidence="10 11">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">POR</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="10">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="10 11"/>
    <dbReference type="AlphaFoldDB" id="A0A670JY58"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030051.1">
        <property type="protein sequence ID" value="ENSPMRP00000028329.1"/>
        <property type="gene ID" value="ENSPMRG00000017929.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156847"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090346">
        <property type="term" value="P:organofluorine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="1 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="84"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="283"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="458"/>
            <end position="461"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="476"/>
            <end position="478"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="492"/>
            <end position="495"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="599"/>
            <end position="600"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="605"/>
            <end position="609"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="681" mass="77642" checksum="BE024FCC97DD3D53" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZW0</accession>
    <name>A0A670JZW0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JZW0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030608.1">
        <property type="protein sequence ID" value="ENSPMRP00000028854.1"/>
        <property type="gene ID" value="ENSPMRG00000018656.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166119"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="3">
        <location>
            <begin position="50"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="135" mass="15233" checksum="D69824561006A51B" modified="2020-06-17" version="1">FPKPLSRLSADPLNCLTADHSWNGFFSSCEAPLYLSSRSLFHLLLYFRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGEKLWEVQCESSTFTVAWHPKRPLLAFACDDKDGKYDSSREAGTVKLFGLPNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0V1</accession>
    <name>A0A670K0V1_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">UTP23 sensor motif region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K0V1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000029800.1"/>
        <property type="gene ID" value="ENSPMRG00000019280.1"/>
    </dbReference>
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    <dbReference type="OMA" id="PDHYILA"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="141" mass="15827" checksum="1CBD8C62852EB23F" modified="2020-06-17" version="1">NEENRDLHRYYDQDLATKVKKKAGVPLLFIIQNTMVLDKPSMKSLASAQAAQTNRLIPEHQKLRIELLKEEQGLAKTSEPRKRKRKRASGPNPLSCLKKKKKGQETLQPSAAKKKGNRKCKKRKLEAGGETVPSGSQNVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K1Y6</accession>
    <name>A0A670K1Y6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Synaptotagmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SYT1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="13">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Chromaffin granule membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">Secretory vesicle</location>
            <location evidence="1 13">Synaptic vesicle membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028601597.1">
        <property type="nucleotide sequence ID" value="XM_028745764.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028601598.1">
        <property type="nucleotide sequence ID" value="XM_028745765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K1Y6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030722.1">
        <property type="protein sequence ID" value="ENSPMRP00000028957.1"/>
        <property type="gene ID" value="ENSPMRG00000018726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605027"/>
    <dbReference type="KEGG" id="pmua:114605027"/>
    <dbReference type="CTD" id="6857"/>
    <dbReference type="GeneTree" id="ENSGT00940000155394"/>
    <dbReference type="OMA" id="AXKEEEL"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042584">
        <property type="term" value="C:chromaffin granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061891">
        <property type="term" value="F:calcium ion sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050750">
        <property type="term" value="F:low-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099502">
        <property type="term" value="P:calcium-dependent activation of synaptic vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098746">
        <property type="term" value="P:fast, calcium ion-dependent exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903235">
        <property type="term" value="P:positive regulation of calcium ion-dependent exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903861">
        <property type="term" value="P:positive regulation of dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014059">
        <property type="term" value="P:regulation of dopamine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051966">
        <property type="term" value="P:regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061669">
        <property type="term" value="P:spontaneous neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071911">
        <property type="term" value="P:synchronous neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08385">
        <property type="entry name" value="C2A_Synaptotagmin-1-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000007">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000016">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF239">
        <property type="entry name" value="SYNAPTOTAGMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="145"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="276"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004349"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="425" mass="47652" checksum="6C1FE9EB40190F46" modified="2020-06-17" version="1">MAKESQHQALAALPGTTVAAALASNVTEPAAPGGKGGPKEDAFSKLKEKFMNELNKIPLPPWALIAIAIVAILLVLTCCFCLCKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKNLKDQALKDDDAETGLTDGEEKEEAKEEEKLGKIQYSLDYNFQDNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEYKVAMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQPEEEVDAMLAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2Y7</accession>
    <name>A0A670K2Y7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K2Y7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032358.1">
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        <property type="gene ID" value="ENSPMRG00000019749.1"/>
    </dbReference>
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    <dbReference type="OMA" id="ARLWCDA"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="248" mass="27315" checksum="BEC1AAE3FB334950" modified="2020-06-17" version="1">MLAVGRETLLPPQVSGGGRQRSRPPARLRCDAPKPRGGRRSSRPPARLRSDAPKPRGGRQRSGPPARLRCDAPKPRGGRRSSRPPARLWCDAPKPRGGRQRSRPPARLRCNAPKPRGGRRSSRSPARLWCDAPKPRGGRQRSRPPARLRCDAPKPRGGRRSSRPPARLRSIVPKPGGGRRSEDSGEVALPRCPGDFPMGCRLAKQAHREIRFAKRLQNGKPFRLAGFPSCEAFVLRGTTVPRIVICMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K306</accession>
    <name>A0A670K306_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ACTL9</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K306"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033835.1">
        <property type="protein sequence ID" value="ENSPMRP00000031903.1"/>
        <property type="gene ID" value="ENSPMRG00000020665.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163012"/>
    <dbReference type="OMA" id="HATERMD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033011">
        <property type="term" value="C:perinuclear theca"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061827">
        <property type="term" value="C:sperm head"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001675">
        <property type="term" value="P:acrosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="395" mass="44813" checksum="60CB842FF3424EE0" modified="2020-06-17" version="1">TFWTRSRASSKEAPRSKTPERGRSVVKTGAVIIDTGTGTCKAGFAGQQTPQAVIGTLVGHPTEKSMRTRRDRPDTFVGERARLEPDVDIILPVRHGIIIDWDAAEVLWRHLFYHDLKVAPEDHALLMSDPPLCPTTNREKLVEVVFESLNSPGMYVAYQSVLSVYAHGKISGLVVDTGHATSHTVPVHQGYNLPHATERMDIAGANMTSFLMDLLRSMGHYFDERMLDVIDDMKQKCCYVAFDFETEWNRPKREYMADYQLPDGQIISLGKERFQCPEMLFNPPQMPGLNLLGLHGMALRSVRKVPEESRKEMYENIMLCGGSSLFEGFEKRFLHDLMVAVPTNTKVKVTAIPLRKYSVWTGGSILASLKNFQPCWIRKEQYHEHGPYIVHRKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3U3</accession>
    <name>A0A670K3U3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pleckstrin homology-like domain family B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein LL5-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PHLDB1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSPMRT00000034149.1">
        <property type="protein sequence ID" value="ENSPMRP00000032208.1"/>
        <property type="gene ID" value="ENSPMRG00000020420.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155231"/>
    <dbReference type="OMA" id="DKKSPFQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045180">
        <property type="term" value="C:basal cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071711">
        <property type="term" value="P:basement membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FHA_PHLB1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_PHLDB1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin homology like domain family B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000004">
        <property type="entry name" value="pleckstrin homology-like domain family B member 1 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052212">
        <property type="entry name" value="PH-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037810">
        <property type="entry name" value="PHLDB1/2/3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156:SF23">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="526"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="606"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="971"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1110"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="796"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1030"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="971"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1367" mass="150594" checksum="9B66B1F8D369387F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4R6</accession>
    <name>A0A670K4R6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable D-lactate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LDHD</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in D-lactate, but not L-lactate catabolic process.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028595154.1">
        <property type="nucleotide sequence ID" value="XM_028739321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K4R6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032495.1">
        <property type="protein sequence ID" value="ENSPMRP00000030639.1"/>
        <property type="gene ID" value="ENSPMRG00000019838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601801"/>
    <dbReference type="KEGG" id="pmua:114601801"/>
    <dbReference type="CTD" id="197257"/>
    <dbReference type="GeneTree" id="ENSGT00940000158705"/>
    <dbReference type="OMA" id="GQGFEWA"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140174">
        <property type="term" value="F:(2R)-2-hydroxycarboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140170">
        <property type="term" value="F:D-lactate dehydrogenase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="probable D-lactate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="58"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="480" mass="51542" checksum="9E5FC9B4D2B9429C" modified="2020-06-17" version="1">MAARRTLGFAVRNYSQAAAKGWLTEDFLDSLRAVVGSTNVSTATPVCEQHGHDESMHRCCPPDAVVWPQNVEQVSLLAKACYSRGAPIIPFGTGTGLEGGVSAVQGGVCFNLTQMDQISELNAEDFTVAVEPGVTRKALNSYLRGSGLWFPVDPGADASLCGMAATSASGTNAVRYGTMRQNVLNLQVVLPDGRVLHTAGQSRRPRKSAAGYHLTGLFVGSEGTLGLITQATLRLHGTPEATVAAICAFPSVQAAVDSTVQVLQTGIPIARIEFLDDVMMAACNRHSGLSYAELPTLFLEFHGTENGVEEQVQATGEIVQSNGGSDFVWAREQEARSQLWAARHNAWYAALALRPGRKGYSTDVCVPISRLPAILLETKKDLLESKLTGPIVGHVGDGNFHCLLIFDPEDAEESRRVAEFSKRLVRRALAMDGTCTGEHGIGLGKRQFLREEVDEVALSTMQQIKAVLDPKNLMNPGKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6V4</accession>
    <name>A0A670K6V4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSPMRP00000032020.1"/>
        <property type="gene ID" value="ENSPMRG00000020728.1"/>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
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    <sequence length="752" mass="88899" checksum="C03AAAC9886A87A9" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013905"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="207" mass="23385" checksum="61CFB76621C7BB09" modified="2020-06-17" version="1">MVKSSLQRILNSHCFAREKEGNKKTHVPADMPALPASAALRSSRVSFSCCSNLGPGPRWCGRGNCQRDHNLSANLFYSDNRLNVTEEITSNNRTRILNVQSRLTDAKHISWKAVLNNNNLYIEIPNGALPEGSKDSFAVLLEFAEEQLQVDHVFICFHKNRDDRASLLRTFSFLGFEIVRPGHALVPKRPDACFMAYTFERDSSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8Y3</accession>
    <name>A0A670K8Y3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K8Y3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033987.1">
        <property type="protein sequence ID" value="ENSPMRP00000032049.1"/>
        <property type="gene ID" value="ENSPMRG00000020770.1"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vomeronasal 2, receptor 73"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
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        <property type="entry name" value="GPCR_3"/>
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    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="652"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="546"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="811" mass="91188" checksum="C2B71805D901B5A6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCM5</accession>
    <name>A0A670KCM5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar protein sorting 13 homolog C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">VPS13C</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000036674.1">
        <property type="protein sequence ID" value="ENSPMRP00000034571.1"/>
        <property type="gene ID" value="ENSPMRG00000021841.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183083"/>
    <dbReference type="OMA" id="SGWRPIR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032127">
        <property type="term" value="C:dense core granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905090">
        <property type="term" value="P:negative regulation of type 2 mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF125">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="5">
        <location>
            <begin position="791"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="5">
        <location>
            <begin position="1232"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="5">
        <location>
            <begin position="1514"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="6">
        <location>
            <begin position="2070"/>
            <end position="2480"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="7">
        <location>
            <begin position="3135"/>
            <end position="3255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="3289" mass="369946" checksum="A0B76E60C4CFF4EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDT7</accession>
    <name>A0A670KDT7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="15">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PPIP5K1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
            <location evidence="2 15">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="15"/>
    <dbReference type="RefSeq" id="XP_028561497.1">
        <property type="nucleotide sequence ID" value="XM_028705664.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028561498.1">
        <property type="nucleotide sequence ID" value="XM_028705665.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028561499.1">
        <property type="nucleotide sequence ID" value="XM_028705666.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028561500.1">
        <property type="nucleotide sequence ID" value="XM_028705667.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028561501.1">
        <property type="nucleotide sequence ID" value="XM_028705668.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000037681.1">
        <property type="protein sequence ID" value="ENSPMRP00000035548.1"/>
        <property type="gene ID" value="ENSPMRG00000022980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584122"/>
    <dbReference type="KEGG" id="pmua:114584122"/>
    <dbReference type="CTD" id="9677"/>
    <dbReference type="GeneTree" id="ENSGT00390000009048"/>
    <dbReference type="OMA" id="AWPRCDA"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HP_HAP_like"/>
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        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
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    </dbReference>
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        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
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        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
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        <property type="entry name" value="His_Pase_clade-2"/>
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        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VIP1_N"/>
    </dbReference>
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        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF11">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="His_Phos_2"/>
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    </dbReference>
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        <property type="entry name" value="PPIP5K2_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
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            <begin position="56"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="911"/>
            <end position="942"/>
        </location>
    </feature>
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        <location>
            <begin position="1150"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1288"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1164"/>
            <end position="1185"/>
        </location>
    </feature>
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        <location>
            <begin position="1215"/>
            <end position="1232"/>
        </location>
    </feature>
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        <location>
            <begin position="1308"/>
            <end position="1318"/>
        </location>
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        <location>
            <begin position="1319"/>
            <end position="1332"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF18086"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1344" mass="149532" checksum="CEE925BF80CEF2B2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KE73</accession>
    <name>A0A670KE73_PODMU</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FGF12</name>
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    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the heparin-binding growth factors family.</text>
    </comment>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="388" mass="42277" checksum="E0F473B432F8241C" modified="2020-06-17" version="1">QQQEEKEGVVISNRSTPPPPPLSPNRNSSRGAENSGHSPSRWIPLLSSPRFLPDRGLPGTKAPRQALLAAPGASARSERRGGEGRRRGGGAHAPCRLPGACAVRTTEAAEWAEPAVVPAAPAPADSSSALRPPPPPPPASGCRESLRRGGARGGAGAEQEEAERKPRRAAGDPGWRSCGSRRRRRRTSTRAHQPSPKFPATSWRPDSSAMEEPQLKGIVTRLFSQQEFFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKAGLYVAMNAEGYLYSSDIFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGRSRKSSGTPTMNGGKVVNQDST</sequence>
</entry>
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        </submittedName>
    </protein>
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        <name evidence="5" type="primary">TTLL11</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Squamata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSPMRG00000023154.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF154">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="673" mass="75653" checksum="D26D038C8B46593E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEL8</accession>
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        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:CatSper complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:flagellated sperm motility"/>
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    </dbReference>
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        <property type="term" value="P:sperm capacitation"/>
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    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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            <begin position="121"/>
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            <begin position="160"/>
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            <begin position="120"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="223" mass="26633" checksum="92F71DA8EFD12888" modified="2020-06-17" version="1">MYIVRFIVEQLCRRHLKEVPFELHPRADAIRSKLIYTFYLIDYLRGLGSAIPRHNIRDFLDHRKLKKLMLTDHHQLVRFNVVPKRNVMITRETRCRNRIRVRCSRWPPVAIWAYSVLNSQIFKVFMIFLICLNMVVLMILVEIRDKLEDHFVKMKIAMEVIIWVIVLIFLVEIGLNWAVSFQDYFKNSWNVFDCTVTIISFIPELELQGKITKPPGLQVLDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KF72</accession>
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        <recommendedName>
            <fullName evidence="1">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Bifurcata</taxon>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="84"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="84" mass="9521" checksum="9C31822A68727E04" modified="2020-06-17" version="1">HAPPPLVPNPQSAIPAGTKWYSLVDLCSAKEEWALLDPDQRALHKEVMEENRGIMASLGKAPSWMIISALKFQREREREREIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGY0</accession>
    <name>A0A670KGY0_PODMU</name>
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            <fullName evidence="8">Phospholipid phosphatase-related protein type 3</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipid phosphate phosphatase-related protein type 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Plasticity-related gene 2 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PLPPR3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KGY0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038415.1">
        <property type="protein sequence ID" value="ENSPMRP00000036251.1"/>
        <property type="gene ID" value="ENSPMRG00000023417.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160280"/>
    <dbReference type="OMA" id="HHPVVQA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidate phosphatase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000014">
        <property type="entry name" value="Phospholipid phosphatase-related protein type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF14">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="14">
        <location>
            <begin position="125"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="643"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="698" mass="75455" checksum="FF4A5044DB6EC9D1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KHC6</accession>
    <name>A0A670KHC6_PODMU</name>
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        <recommendedName>
            <fullName evidence="9">BAR/IMD domain-containing adapter protein 2-like 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BAIAP2L1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028705557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KHC6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037158.1">
        <property type="protein sequence ID" value="ENSPMRP00000035044.1"/>
        <property type="gene ID" value="ENSPMRG00000022679.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114584075"/>
    <dbReference type="CTD" id="55971"/>
    <dbReference type="GeneTree" id="ENSGT00940000153560"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0070064">
        <property type="term" value="F:proline-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SH3_BAIAP2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Brain-specific angiogenesis inhibitor 1-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000043">
        <property type="entry name" value="Brain-specific angiogenesis inhibitor 1-associated protein 2-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030060">
        <property type="entry name" value="Baiap2l1_I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
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        <property type="entry name" value="IRSp53/IRTKS/Pinkbar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035592">
        <property type="entry name" value="IRTKS_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206:SF4">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="IMD" evidence="14">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="340"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="446"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="512" mass="57215" checksum="483EF7404853ADD5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KHG0</accession>
    <name>A0A670KHG0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neurofilament heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NEFH</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566537.1">
        <property type="nucleotide sequence ID" value="XM_028710704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KHG0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038953.1">
        <property type="protein sequence ID" value="ENSPMRP00000036783.1"/>
        <property type="gene ID" value="ENSPMRG00000023689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586861"/>
    <dbReference type="KEGG" id="pmua:114586861"/>
    <dbReference type="CTD" id="4744"/>
    <dbReference type="GeneTree" id="ENSGT00940000154418"/>
    <dbReference type="OMA" id="FHSWTRT"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005883">
        <property type="term" value="C:neurofilament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099184">
        <property type="term" value="F:structural constituent of postsynaptic intermediate filament cytoskeleton"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045110">
        <property type="term" value="P:intermediate filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23214:SF1">
        <property type="entry name" value="NEUROFILAMENT HEAVY POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23214">
        <property type="entry name" value="NEUROFILAMENT TRIPLET H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="12">
        <location>
            <begin position="99"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="458"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="103"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="298"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="460"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="667"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="696"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="951" mass="103973" checksum="2C31875393C6AB97" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KI69</accession>
    <name>A0A670KI69_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Prostaglandin E synthase 3</fullName>
            <ecNumber evidence="4">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cytosolic prostaglandin E2 synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PTGES3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670KI69"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036529.1">
        <property type="protein sequence ID" value="ENSPMRP00000034432.1"/>
        <property type="gene ID" value="ENSPMRG00000022334.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154256"/>
    <dbReference type="OMA" id="IEHKVTD"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019371">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042921">
        <property type="term" value="P:nuclear receptor-mediated glucocorticoid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032212">
        <property type="term" value="P:positive regulation of telomere maintenance via telomerase"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043588">
        <property type="term" value="P:skin development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905323">
        <property type="term" value="P:telomerase holoenzyme complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00237">
        <property type="entry name" value="p23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000003">
        <property type="entry name" value="prostaglandin E synthase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF3">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="17">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="159" mass="18507" checksum="5A41211E45D0E228" modified="2020-06-17" version="1">QPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLSFSCLGGNDNFKHLNEIDLYNSIDPNESKHKRTDRSVLCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDLSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSPDSDDEKMPDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIC5</accession>
    <name>A0A670KIC5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RAD23A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KIC5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038961.1">
        <property type="protein sequence ID" value="ENSPMRP00000036791.1"/>
        <property type="gene ID" value="ENSPMRG00000023693.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012078"/>
    <dbReference type="OMA" id="VACCVRI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990381">
        <property type="term" value="F:ubiquitin-specific protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045787">
        <property type="term" value="P:positive regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045070">
        <property type="term" value="P:positive regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14377">
        <property type="entry name" value="UBA1_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14427">
        <property type="entry name" value="UBA2_HR23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.540:FF:000001">
        <property type="entry name" value="UV excision repair protein RAD23 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041811">
        <property type="entry name" value="RAD23A/B_UBA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF29">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="379" mass="41971" checksum="94B3FC65F4DEC6B3" modified="2020-06-17" version="1">MWLMDQFKYLYSHAYWGGKSLTLRHSVQDRWWNQFGLDPQVRVLKEKIEAEKGKEAFPVSGQKLIYAGKILSDDVPIKEYKIDEKNFVVVMVTKNKTGSGAPVPSPSEAAPPSEPTPSSGQMLLPGAATVSPPLGTPTSEEKPPEESVTVSPQESVGSVPSSGSMGREDDAASTLVTGSEYETMLNEIMSMGYERERVVAALRASYNNPHRAVEYLLTGIPGSPEPERASIQESQPQEQSAPEGENPLEFLRDQPQFQNMRQVIQQNPALLPALLQQLGQENPQLLQQISQHQEQFIQMLNEPLGEVPDIADIEGEMGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQNFDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIW7</accession>
    <name>A0A670KIW7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KIW7"/>
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        <property type="protein sequence ID" value="ENSPMRP00000035584.1"/>
        <property type="gene ID" value="ENSPMRG00000023011.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234712"/>
    <dbReference type="OMA" id="EKERIQX"/>
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        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="544" mass="62323" checksum="05590992EDF2159A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJ81</accession>
    <name>A0A670KJ81_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear factor interleukin-3-regulated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114587861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028568526.1">
        <property type="nucleotide sequence ID" value="XM_028712693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KJ81"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039326.1">
        <property type="protein sequence ID" value="ENSPMRP00000037141.1"/>
        <property type="gene ID" value="ENSPMRG00000023902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587861"/>
    <dbReference type="KEGG" id="pmua:114587861"/>
    <dbReference type="GeneTree" id="ENSGT00940000164623"/>
    <dbReference type="OMA" id="ANAMAHF"/>
    <dbReference type="OrthoDB" id="6151507at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14694">
        <property type="entry name" value="bZIP_NFIL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047229">
        <property type="entry name" value="NFIL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047106">
        <property type="entry name" value="NFIL3-like_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284:SF4">
        <property type="entry name" value="E4 BINDING PROTEIN 4-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284">
        <property type="entry name" value="NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="452" mass="49139" checksum="1FBDC118809A4013" modified="2020-06-17" version="1">MESLNSPTLCSPGSFPGFHQDGMMQRARALKGKPSANCRRKREFISDEKKDASYWEKRRKNNEAAKRSREKRRFNDLVLENRVMALNEENVRLKTELLQLKLRFGLISTAAFMEKSQQLSAASANAMAHFYESSDGSMYSGSSLSRAHHSEDSSETEQSSRDSGSVSAAKYSSRGSLSDMSDGSSRDSPMPQTLGEAQAVSRAYGEAPSQHHPEPKTPVARGVILFSANGFTAVAAPQPLLPEREERAGGRGAGEAPKSPCMEQEGHSQREELPPHPGYCTKPPSYSTPSGYLEGDLPQVEHMRKAQAPQSPFEGYSSEESGEERSWGGSPVPYPGPLDAHPDVRTAALPHKLRLKCRAHSSGVQELFPGPSTVPAGCCQEAPVAPDWAGDRPEEMSALVRQALLLNEQPATGGALERLLCRGSGVHSDNSVPKDLVSRWEEGCHDDGPRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKF3</accession>
    <name>A0A670KKF3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin family domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UBFD1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028561403.1">
        <property type="nucleotide sequence ID" value="XM_028705570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KKF3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038386.1">
        <property type="protein sequence ID" value="ENSPMRP00000036224.1"/>
        <property type="gene ID" value="ENSPMRG00000023402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584081"/>
    <dbReference type="KEGG" id="pmua:114584081"/>
    <dbReference type="CTD" id="56061"/>
    <dbReference type="GeneTree" id="ENSGT00390000012857"/>
    <dbReference type="OMA" id="SEPIKEH"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17047">
        <property type="entry name" value="Ubl_UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039120">
        <property type="entry name" value="UBFD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057455">
        <property type="entry name" value="UBFD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470:SF0">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25343">
        <property type="entry name" value="PH_UBFD1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="291" mass="32372" checksum="F885041B3779F8D1" modified="2020-06-17" version="1">MAAASATPDSDDTSMDAEAENPPLDCRDGSDPLSAEKPLETDDPQSDPPDPQASVSNGGDSEIGKELVELKIIWNKNKYDLKFPLDNTGADLKQKIHSLTGLPPAMQKVMFKGLLPEDKTLREIKVINGAKIMVVGSTINDVLAVNTPKDAAQQEVKSEETKKEPLCRQKQHRKVLDKGKPEDVMPSVKGAQERLPTVPLSGMYNKSGGKVRLTFKLEQDQLWIGTKERTEKLPMGSIKNVVSEPIEGHEDYHMMAFQLGPTEASYYWVYWVPTQYVDAIKDTVLGKWQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLD5</accession>
    <name>A0A670KLD5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Heparanase</fullName>
            <ecNumber evidence="10">3.2.1.166</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HPSE</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>endohydrolysis of (1-&gt;4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan.</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 79 family.</text>
    </comment>
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    <dbReference type="Ensembl" id="ENSPMRT00000037654.1">
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    <dbReference type="KEGG" id="pmua:114604526"/>
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    <dbReference type="GeneTree" id="ENSGT00390000004874"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005764">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:heparanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045545">
        <property type="term" value="F:syndecan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cell-matrix adhesion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:establishment of endothelial barrier"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:heparin proteoglycan metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of blood coagulation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of osteoblast proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of vascular endothelial growth factor production"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein transmembrane transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:vascular wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005199">
        <property type="entry name" value="Glyco_hydro_79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46145">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEPARANASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03662">
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    </dbReference>
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        <location>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00036917"/>
        </source>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039100"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040414"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035522.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="539" mass="60701" checksum="B04E2BDB92CF571F" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A670KNA3</accession>
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        <recommendedName>
            <fullName evidence="5">L1 transposable element RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="242"/>
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        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="29870" checksum="BDA1607D9F4AFDCB" modified="2020-06-17" version="1">MRLLTKLRTQAVEEGLKKTRLEMKDVRREEDRIKADILDLNKNQEEMKDLIAMNELRQKEVNLRLRAVPETQGENIKVKLTTELATWLEIPIEEMANAIQSAFRLKTKSAKNKRFVGDCLVVFKEREMRNMILQKNKEKRLNIGGNYIIIFKDIPVRLLKRRDSYKELVQALKRFNIEFKWEFPEGISFIYKSKRQKLTSPEETSKFLRKYKELRVDKEEDKSEEIERKADSEEETERSGGEEEEEGGEGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HKD5</accession>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="544" mass="62148" checksum="9449022B1DB3E49C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HLN9</accession>
    <name>A0A670HLN9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lamin tail domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LMNTD2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028593862.1">
        <property type="nucleotide sequence ID" value="XM_028738029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HNA6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001435.1">
        <property type="protein sequence ID" value="ENSPMRP00000001349.1"/>
        <property type="gene ID" value="ENSPMRG00000001015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601043"/>
    <dbReference type="KEGG" id="pmua:114601043"/>
    <dbReference type="CTD" id="5007"/>
    <dbReference type="GeneTree" id="ENSGT00940000156164"/>
    <dbReference type="OMA" id="WDEKMDY"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035627">
        <property type="term" value="P:ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006686">
        <property type="term" value="P:sphingomyelin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13284">
        <property type="entry name" value="PH_OSBP_ORP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000074">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="80"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="799" mass="89280" checksum="94B0056FD72B7C04" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPA3</accession>
    <name>A0A670HPA3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of rudimentary homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May have a role in the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the E(R) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HPA3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EHR_sf"/>
    </dbReference>
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        <property type="entry name" value="ERH"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="107" mass="12662" checksum="6F8C86CEF55E3F70" modified="2020-06-17" version="1">AGTERRELTPPRGFEPSNAHTILLVQPTKQPEGRTYRLKRMNLKYTWSRDPSTTYDISQLFDFIDNLADLSSLVYRADTQTYQPYNKDWIKEKTYVFLRRQAQQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPC2</accession>
    <name>A0A670HPC2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease P protein subunit p30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNase P subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RPP30</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HPC2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001617.1">
        <property type="protein sequence ID" value="ENSPMRP00000001518.1"/>
        <property type="gene ID" value="ENSPMRG00000001121.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000883"/>
    <dbReference type="OMA" id="NIYFEIC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000031">
        <property type="entry name" value="ribonuclease P protein subunit p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="270" mass="30535" checksum="5B9B4CE5D3DCE5A6" modified="2020-06-17" version="1">MLEGMDPFQLCYDFKLGPSHIPARCETGAEEKERGRKDYNSQHAAGRQGIRSCASPPRGFNMAEFVDLNIPHLAEKASLQKLVEAAAHLGYSTVAINYVVDYDEKKKEIVKPLSPKELFTVLPLVQGKSKPIKILSRLTLVVSDPSHCNILRSTSTNIKFYDIFAVFPKSGKLFHVACTTLDVDIVCINVTEKLPFYIKRPSVNVAIDRGIYFELIYVPAIKDSTMRRYTVSNALSLMQICRGKVRLKMSRFAPLLFRQNFPPPFQLMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPV9</accession>
    <name>A0A670HPV9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Oocyte zinc finger protein XlCOF6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114592570</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028576649.1">
        <property type="nucleotide sequence ID" value="XM_028720816.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028576650.1">
        <property type="nucleotide sequence ID" value="XM_028720817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HPV9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001334.1">
        <property type="protein sequence ID" value="ENSPMRP00000001260.1"/>
        <property type="gene ID" value="ENSPMRG00000000941.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592570"/>
    <dbReference type="KEGG" id="pmua:114592570"/>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="YECMESL"/>
    <dbReference type="OrthoDB" id="9033588at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002565">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001621">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000263">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000353">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000023">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000466">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF129">
        <property type="entry name" value="RIKEN CDNA 9130023H24 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="579" mass="66410" checksum="5E7DBDB38D441E44" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQN4</accession>
    <name>A0A670HQN4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQN4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001974.1">
        <property type="protein sequence ID" value="ENSPMRP00000001856.1"/>
        <property type="gene ID" value="ENSPMRG00000001374.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="HWRCLEM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003095">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000514">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000551">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002196">
        <property type="entry name" value="zinc finger protein 850-like isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="112"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="673" mass="76278" checksum="8B2223F5A6F3B623" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HS25</accession>
    <name>A0A670HS25_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 397-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114592195</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028576005.1">
        <property type="nucleotide sequence ID" value="XM_028720172.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028576006.1">
        <property type="nucleotide sequence ID" value="XM_028720173.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028576007.1">
        <property type="nucleotide sequence ID" value="XM_028720174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HS25"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002152.1">
        <property type="protein sequence ID" value="ENSPMRP00000002025.1"/>
        <property type="gene ID" value="ENSPMRG00000001489.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592195"/>
    <dbReference type="KEGG" id="pmua:114592195"/>
    <dbReference type="GeneTree" id="ENSGT00940000153165"/>
    <dbReference type="OMA" id="KHESIHA"/>
    <dbReference type="OrthoDB" id="9028788at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000029">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000895">
        <property type="entry name" value="Zinc finger protein 597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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</entry>
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                <person name="Wallerman O."/>
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                <person name="Bellati A."/>
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                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <text>3-demethylubiquinone-10 + NADH + 2 H(+) = 3-demethylubiquinol-10 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:83243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64182"/>
            <dbReference type="ChEBI" id="CHEBI:231824"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-demethylubiquinone-10 + NADPH + 2 H(+) = 3-demethylubiquinol-10 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:83247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:64182"/>
            <dbReference type="ChEBI" id="CHEBI:231824"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-demethylubiquinone + NADH + 2 H(+) = a 3-demethylubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:83235"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 3-demethylubiquinone + NADPH + 2 H(+) = a 3-demethylubiquinol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:83239"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028578909.1">
        <property type="nucleotide sequence ID" value="XM_028723076.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578911.1">
        <property type="nucleotide sequence ID" value="XM_028723078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HVY3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004157.1">
        <property type="protein sequence ID" value="ENSPMRP00000003889.1"/>
        <property type="gene ID" value="ENSPMRG00000002681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594005"/>
    <dbReference type="KEGG" id="pmua:114594005"/>
    <dbReference type="CTD" id="84816"/>
    <dbReference type="GeneTree" id="ENSGT00880000138028"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008753">
        <property type="term" value="F:NADPH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08248">
        <property type="entry name" value="RTN4I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000147">
        <property type="entry name" value="Reticulon-4-interacting protein 1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000009">
        <property type="entry name" value="Reticulon-4-interacting protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037397">
        <property type="entry name" value="RTN4IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="20">
        <location>
            <begin position="61"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="471" mass="51689" checksum="E4BF87F512378910" modified="2020-06-17" version="1">MLLKVHTFSRKVFSSLLHCPGLGVTCLGMGKSLIQQLPCRNFHVSCQRCTMMPSWVIDRYGKNDVLRFTNNMMFPLINFPNEVIIKVHAASLNPIDVNMRSGYGAAAIRMKRDPLHITSTGSEFPLTLGRDVSGVVMECGLDVKYFRPGDEVWAAVPPWKQGTLSEFVLASGNEISKKPRCLSHTQAASLPYAGLTAWSAIRHAGGLNQDNCSNKRVLIFGAAGGVGTFAIQLMKAWGAHVTAVCSQDASELVKRLGADDVIDYKSGSVEEQLKTLPLFDFILDNVGGSTEKWAPDFLKKWSGATYVSLITPFLVNMDRLGVADGMLRTGMTFGSKTFKHLCKGVHYRWAFFAPSGPYLDEIADLVDAGKIHPVIDQVFSFSDVPKAFQKMEEGHARGKTLQTEGILTVILEGFSTNTYAGSAQLTAEQSVDVKTDGVSSRIQTTDILQYDCIFFLLLFPAFMLNWAISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWC6</accession>
    <name>A0A670HWC6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">POFUT2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670HWC6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003635.1">
        <property type="protein sequence ID" value="ENSPMRP00000003392.1"/>
        <property type="gene ID" value="ENSPMRG00000002339.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007989"/>
    <dbReference type="OMA" id="RNAVWPI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903334">
        <property type="term" value="P:positive regulation of protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010717">
        <property type="term" value="P:regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11298">
        <property type="entry name" value="O-FucT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11340:FF:000002">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000002">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="434" mass="50910" checksum="FD63F088990F5C0F" modified="2020-06-17" version="1">MESSPLEWLSSFCSKIPFPDGEQSNPNSWMRQVPCSTRLSEETLPPWRSLYLLYDVNPPEGFNLRRDVYIRVASLIKTLLKHEAWVLVLPPWGRLYHWQSPDIHQIRIPWFEFFDVPSLSKNIPVIEYEEFLAESGGPFIDQVYVLQSYAEGWKDGTWEEKIDERPCIDQLMYSTDKHKYYRGWFWGYEETRGMNVACLSVQGSASVIAPLLLNISARSVMLDRAENLLHDHYGGKDYWNTRRSMVFAKHLRVVGDMFRTKFLNSTDEKDRTQYSEDWTKMKVKLGTAIGGPYLGAHLRRKDFIWGHRNDVPSIQGAVETIRRLLKLHKLQRVFIATDAIAKETEELKRLLPEMVRFEPNWEELELYKDGGIAIIDQWICAHARYFIGTSVSTFSFRIHEEREILGFDPKTTYNRFCGDEESTCEQPTHWKIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ15</accession>
    <name>A0A670HZ15_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ceramide kinase like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CERKL</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028604028.1">
        <property type="nucleotide sequence ID" value="XM_028748195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HZ15"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004747.1">
        <property type="protein sequence ID" value="ENSPMRP00000004450.1"/>
        <property type="gene ID" value="ENSPMRG00000003043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606226"/>
    <dbReference type="KEGG" id="pmua:114606226"/>
    <dbReference type="CTD" id="375298"/>
    <dbReference type="GeneTree" id="ENSGT00940000157578"/>
    <dbReference type="OMA" id="CYLWYRS"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046625">
        <property type="term" value="F:sphingolipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045363">
        <property type="entry name" value="CERK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057465">
        <property type="entry name" value="CERK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF26">
        <property type="entry name" value="CERAMIDE KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19280">
        <property type="entry name" value="CERK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25382">
        <property type="entry name" value="PH_CERK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="188"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="563" mass="62292" checksum="A15BC73F1277085D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZW3</accession>
    <name>A0A670HZW3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fructose-2,6-bisphosphatase TIGAR</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">TP53-induced glycolysis and apoptosis regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TIGAR</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <dbReference type="EC" id="3.1.3.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028584629.1">
        <property type="nucleotide sequence ID" value="XM_028728796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HZW3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005577.1">
        <property type="protein sequence ID" value="ENSPMRP00000005234.1"/>
        <property type="gene ID" value="ENSPMRG00000003595.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596927"/>
    <dbReference type="KEGG" id="pmua:114596927"/>
    <dbReference type="CTD" id="57103"/>
    <dbReference type="GeneTree" id="ENSGT00940000163946"/>
    <dbReference type="OMA" id="PTIQCVC"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
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            <begin position="164"/>
            <end position="180"/>
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        <location>
            <position position="16"/>
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            <position position="94"/>
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        <ligand>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
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    <sequence length="281" mass="31003" checksum="AA62CC3D153ED9DF" modified="2020-06-17" version="1">MGRMRPAAFGLTVVRHGETRYNKEKILQGQGIDEPLSETGFRQANAAGLYLSNIKFTHVFTSDLLRAKQTTDAILKKSKFCKDVAVKYDARLRERKYGAAEGRPLSDLRTMAKAAGEQCPSFTPPGGETLEEVKARGKDFFEHLCCLVAQEACPENKAEEETEGSSTEMAGGSSTSSLTNHHSRLEFNSDRGAEILDANILVVSHGAFMRSWVGYFISDLACTLPSALSKTELSSVSPNTGISRFNIKLEMREDSKPKIHCVFLNRDDHLGEKMMAGNMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I2E5</accession>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <location>
            <begin position="260"/>
            <end position="534"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1013" mass="120021" checksum="43B5A3D19B0F9441" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I2H9</accession>
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        <recommendedName>
            <fullName evidence="11">Syntaxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">STX7</name>
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    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Early endosome membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028579275.1">
        <property type="nucleotide sequence ID" value="XM_028723442.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028579277.1">
        <property type="nucleotide sequence ID" value="XM_028723444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I2H9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006558.1">
        <property type="protein sequence ID" value="ENSPMRP00000006168.1"/>
        <property type="gene ID" value="ENSPMRG00000004166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594151"/>
    <dbReference type="KEGG" id="pmua:114594151"/>
    <dbReference type="CTD" id="8417"/>
    <dbReference type="GeneTree" id="ENSGT01000000214440"/>
    <dbReference type="OMA" id="LMTYTKQ"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042582">
        <property type="term" value="C:azurophil granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:synaptic vesicle"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:tertiary granule"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:chloride channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:SNAP receptor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of receptor localization to synapse"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd15875">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
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        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF90">
        <property type="entry name" value="SYNTAXIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="162"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="165"/>
            <end position="220"/>
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</entry>
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    </dbReference>
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        </source>
    </evidence>
    <sequence length="270" mass="28959" checksum="B23478C49D7E1714" modified="2020-06-17" version="1">TMNSDSSSLSSRASSPDMEEMYLRDHHHHHHHHHHSVSSTQSEVGQRGPGEGLSRAGSKGSSSESSKYKIKKQLSEQDLQQLRLKINGRERKRMHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGEIYGGHHSAFHCGTVAHSAGHPAHPPGAVHPVHPILGGALSSGGNPPPLSASLPAIGAIRPPHSLLKTPPAPPALQLGGGFQHWAGLPCPCSICQMPPPPHLSALTTTASLARISTEAKDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5D2</accession>
    <name>A0A670I5D2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein SOUL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HEBP2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Monomer. Interacts with LRPPRC. May interact with BCL2L1; an interaction with BCL2L1 was observed using a peptide, but not with the full-length protein. The full-length protein would have to undergo a major conformation change for the interaction to occur. Interacts with PDCD6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028579387.1">
        <property type="nucleotide sequence ID" value="XM_028723554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I5D2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007409.1">
        <property type="protein sequence ID" value="ENSPMRP00000006926.1"/>
        <property type="gene ID" value="ENSPMRG00000004720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594189"/>
    <dbReference type="KEGG" id="pmua:114594189"/>
    <dbReference type="CTD" id="23593"/>
    <dbReference type="GeneTree" id="ENSGT00940000160412"/>
    <dbReference type="OMA" id="YEIRTYH"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000006">
        <property type="entry name" value="heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF70">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="206" mass="23349" checksum="05F2849AC4946E96" modified="2020-06-17" version="1">MQGERGRDGRCCRQTERMLKTIKQALFSTGLEMPKWTALPNQASDYEIRQYEPAKWVCTSVKTVDWDSAINTGFTKLFNYIKGKNEKGVKIDMTAPVTCYVQPGAGPFCESTTTVSFYVPPQHQANPPKPSEADVFIETRPAITVFVRSFGGFANAKKNQDEILALAESLKRDGKTFQEKVYYTAGYDSPFKLLNRHNEVWLIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6N1</accession>
    <name>A0A670I6N1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Cholesterol transporter ABCA5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">ATP-binding cassette sub-family A member 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>cholesterol(in) + ATP + H2O = cholesterol(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:39052"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000007840.1">
        <property type="protein sequence ID" value="ENSPMRP00000007324.1"/>
        <property type="gene ID" value="ENSPMRG00000004575.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158172"/>
    <dbReference type="OMA" id="MNPLWPD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010874">
        <property type="term" value="P:regulation of cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043691">
        <property type="term" value="P:reverse cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000729">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF100">
        <property type="entry name" value="CHOLESTEROL TRANSPORTER ABCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="18" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1019"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
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        <location>
            <begin position="1205"/>
            <end position="1226"/>
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        <location>
            <begin position="477"/>
            <end position="712"/>
        </location>
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        <location>
            <begin position="1287"/>
            <end position="1527"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="1635" mass="185957" checksum="841D9B9653D4C9E3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8B8</accession>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>IDENTIFICATION</scope>
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</entry>
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    <accession>A0A670IAC8</accession>
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        <recommendedName>
            <fullName evidence="7">Myeloid-associated differentiation marker-like protein 2</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MAL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IAC8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009427.1">
        <property type="protein sequence ID" value="ENSPMRP00000008825.1"/>
        <property type="gene ID" value="ENSPMRG00000005941.1"/>
    </dbReference>
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    <dbReference type="OMA" id="TGGPYLN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047123">
        <property type="entry name" value="MYADM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068:SF5">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="10">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="10">
        <location>
            <begin position="143"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034721"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040733"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="291" mass="31894" checksum="B57E7501C2E7AEB5" modified="2025-10-08" version="2">MGETDHSRGTHLNMAAVASRVGAARLLQAAFGCTTFSLVAHRGGFSAAYGTFCMSVWCFCFAVTVFIVTCEFTRLHSCLSISWGNFTAAFAMLATLMSITAAVIYPLYVEFGCHSNGCEARDFRISASVFAGLLAKPGQVTSYMATVSGLLKIVQAFVACIIFGALVNGSQYDRYVATQWCVAVYSFCFVVTVVVVALSVTGKTAMLKCPFERFVVVYTFVAVLMYLSAAVIWPVFCFDRKYGSPHRPYQCSRGKCPWDSQVVIAVFTCVNLVLYIVDLAYSQRIRFVSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICS2</accession>
    <name>A0A670ICS2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PARP</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ARTD/PARP family.</text>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF70">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP9"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="259"/>
        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49488" checksum="65CC594F8AFDFC04" modified="2020-06-17" version="1">CFRCAAIPLAVLASGIQNIFFLMPIDEEMLSIPISNNVYAILKRRENYLCSLLEKKFGCITVLKSIRNPTEVYRKSLKEGIEVSVWVDDLTRHEADALVNAANEYLHHFGGLAFALLKAGGPEIEEHCKHFIEKNGPLSAGQIAVTSGGRLHCKQVIHAVGPRWSEEQREECCLKLEAAIINILKYVNAPENNIKSVAIPALSSGIFNFPQDLCAQVIVRTIKNFIQLAPLFGYLQEIHLVNIDETTAEAMKRACEELLAGHNLLSFSFQIEKICNPLLESTFQRIKIKIEGKNAGMPVCHRLYHRVPAQYCSLVCKTGFQKTYPSSLQGKKYGAGIYFNKNPRNLVTDTREKCEMDHLICVFEAEVVTGSYTRGNRSYVAPPLISASSMKLYDSVVDDIHNPEIFVIFNREQALPLYLLTCSLLWNPVQKTQLEPSAQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICW6</accession>
    <name>A0A670ICW6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquilin 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ICW6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010077.1">
        <property type="protein sequence ID" value="ENSPMRP00000009447.1"/>
        <property type="gene ID" value="ENSPMRG00000006338.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156437"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="UBA"/>
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        <property type="entry name" value="Ubiquilin"/>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF16">
        <property type="entry name" value="UBIQUILIN-1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="4">
        <location>
            <begin position="532"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="64218" checksum="5D44D0CBECA30260" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDS2</accession>
    <name>A0A670IDS2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IDS2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010727.1">
        <property type="protein sequence ID" value="ENSPMRP00000010070.1"/>
        <property type="gene ID" value="ENSPMRG00000006728.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286903"/>
    <dbReference type="OMA" id="GEICHYQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="75" mass="8225" checksum="49B07C9E725C6CA7" modified="2020-06-17" version="1">VARTKQIACESTGGKAPHKQLAAKAARKSTPSTSGVKVPNRYRPGTVALGEICHYQKSTELLIHKLPFQRLVRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDX1</accession>
    <name>A0A670IDX1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IDX1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010546.1">
        <property type="protein sequence ID" value="ENSPMRP00000009899.1"/>
        <property type="gene ID" value="ENSPMRG00000006622.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234712"/>
    <dbReference type="OMA" id="CGLAYAT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="482" mass="55168" checksum="4D69A27B60CE46ED" modified="2020-06-17" version="1">LAVLPVQRSEGAGLLLRQVISCGRSLSELAGQQLKEENSWRTGEVPADWRRANVVPIFKKGKREDPNNYRPVSLTSIPGKILEQIIKQTVCEHLERNAVITNSQHGFLKNKSCQTNLVSFFDRITSLVDEGNAVDVVYLDFSKAFDKVPHDILVKKLVKCGLAYATTQWICNWLTDRTQRVLINGSSSSWRRVTSGVPQGSVLGPVLFNIFINDLDDGLKGILIKFADDTKLGGVANTPEDRITLQNDLDRLENWAKTNKMNFNREKCKVLHLGKKNERHKYKMGDTWLESSTCEKDLGVLVDHKLDMSQQCDAAAKKANAILGLINRSIASRSREVIVPLYSALVRPHLEYCVQFWAPQFKKDTDKLERVQRRATKMVKGLERMPYEERLRELGMFSLEKRRLRGDMISMFKYIKGCHIEEGERLFSAAPEKRTRSNRSKLQERRFHLNIRKNFLTVRAVQQWNLLPRSVVESPSLEVFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IF54</accession>
    <name>A0A670IF54_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCAAT/enhancer-binding protein zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCAAT-box-binding transcription factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CEBPZ</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Stimulates transcription from the HSP70 promoter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028580021.1">
        <property type="nucleotide sequence ID" value="XM_028724188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IF54"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011045.1">
        <property type="protein sequence ID" value="ENSPMRP00000010371.1"/>
        <property type="gene ID" value="ENSPMRG00000006892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594470"/>
    <dbReference type="KEGG" id="pmua:114594470"/>
    <dbReference type="CTD" id="10153"/>
    <dbReference type="GeneTree" id="ENSGT00390000006395"/>
    <dbReference type="OMA" id="EIWCNDE"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000805">
        <property type="entry name" value="Similar to transcription factor CBF/MAK21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="12">
        <location>
            <begin position="523"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="868"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="879"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="923"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1049" mass="119818" checksum="6D9B91489467A756" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFE3</accession>
    <name>A0A670IFE3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Synapse-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">BSD domain-containing signal transducer and Akt interactor protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SYAP1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts (via phosphorylated form and BSD domain) with AKT1; this interaction is enhanced in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation and activates AKT1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583444.1">
        <property type="nucleotide sequence ID" value="XM_028727611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IFE3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011131.1">
        <property type="protein sequence ID" value="ENSPMRP00000010443.1"/>
        <property type="gene ID" value="ENSPMRG00000006946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596256"/>
    <dbReference type="KEGG" id="pmua:114596256"/>
    <dbReference type="CTD" id="94056"/>
    <dbReference type="GeneTree" id="ENSGT00390000007662"/>
    <dbReference type="OMA" id="DTCNLNQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990314">
        <property type="term" value="P:cellular response to insulin-like growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036120">
        <property type="term" value="P:cellular response to platelet-derived growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3970.10:FF:000001">
        <property type="entry name" value="synapse-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF6">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="7">
        <location>
            <begin position="179"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00058614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00065448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="370" mass="41976" checksum="6144C6DC14A4EC27" modified="2020-06-17" version="1">MLRGLSGWFGMSREGEEEKPPLLEGEAGAAAAAEEGEEGTGGDAAVRSPEQVELQRDSDPLLNQAKGLGKQLQMQHLGKGYLFSFATTATKKISESVAETAQTIKKSVEEGKIENIIDKTIIGDFQKEQKKFVQQQQTKKSEAAVPPWVDSNEEETIQQQILALSADRRNFLRDPPAGVQFNFDFDQMYPVALVMLQEDELLNRMRFDLVPKHVKEDVFWRNYFYRVSLIKQSAQLTALAAQQQAVRKEQNGSQEDRQLAETVRPKTPPVAIKSQLKPQEEEEEISTSPGVSEFVSDAFDSCSLNREDLRKEIEQLVLDKSKETTTVEEETADWEKELQQELQEYEVVAESEKRDDNWDKEIEEMLQGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFK4</accession>
    <name>A0A670IFK4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IFK4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011165.1">
        <property type="protein sequence ID" value="ENSPMRP00000010469.1"/>
        <property type="gene ID" value="ENSPMRG00000006970.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234712"/>
    <dbReference type="OMA" id="ENSWRIG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="509" mass="58449" checksum="0E519E250F5D6FEF" modified="2020-06-17" version="1">MPNYTFTCSITKEIVQEYLASLDVFKSPGPDELHPRVLKELADVISEPLAVIFENSWRIGEVPADWRRANVVPIFKKGKREDPNNYRPVSLTSIPGKILEQIIKQTVCEHLERNAVITNSQHGFLKNKSCQTNLFSFFDRITTLVDEGNAVDVAYLDFSKAFDKVPHDILVKKLVKCGLDYATTQWICNWLTDRTQRVLINGSSSSWRRVTSGVPQGSVLGPVLFNIFINDLDDGLKGILIKFADDTKLGGVANTPEDRITLQNDLDRLENWAKTNKMNFNREKCKVLHLGKKNERHKYKMGDTWLESSTCEKDLGVLVDHKLDMSQQCDAAAKKANAILGCINRSIASRSREVIVPLYSALVRPHLEYCVEFWAPQFKKDSDKLERVQRRATKMVKGLETMPYEERLRELGMFSLEKRRLRGDMIAMFKYIKGCHIEEGERLFSAAPEKRTRSNGSKLQERRFHLNIRKNFLTVRAVRQWNLLPRSVVESPSLEVFKQRLDNHMSGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGM2</accession>
    <name>A0A670IGM2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoprotein M6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GPM6B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the myelin proteolipid protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IGM2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011725.1">
        <property type="protein sequence ID" value="ENSPMRP00000010978.1"/>
        <property type="gene ID" value="ENSPMRG00000007297.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006915"/>
    <dbReference type="OMA" id="XIQLMQY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019911">
        <property type="term" value="F:structural constituent of myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022010">
        <property type="term" value="P:central nervous system myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051612">
        <property type="term" value="P:negative regulation of serotonin uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030501">
        <property type="term" value="P:positive regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018237">
        <property type="entry name" value="Myelin_PLP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF10">
        <property type="entry name" value="NEURONAL MEMBRANE GLYCOPROTEIN M6-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00214">
        <property type="entry name" value="MYELINPLP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00002">
        <property type="entry name" value="PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00575">
        <property type="entry name" value="MYELIN_PLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01004">
        <property type="entry name" value="MYELIN_PLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="301" mass="33263" checksum="27418B95356352DE" modified="2020-06-17" version="1">METAAEENTEQSQEKKVITRPEMEIGRYQWMYRNSRLHQYHHVPALRGNVSPLGIQGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVSILEQRFSTNVTDHALLSEVIKLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTICGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIRSLPANMTASADQICVDIRQYGIIPWNAVPGKACGSALADMCSTPEFYLSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIA7</accession>
    <name>A0A670IIA7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bromodomain testis-specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BRDT</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the BET family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IIA7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012073.1">
        <property type="protein sequence ID" value="ENSPMRP00000011301.1"/>
        <property type="gene ID" value="ENSPMRG00000007548.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154549"/>
    <dbReference type="OMA" id="QPKTEIA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140008">
        <property type="term" value="F:histone H4 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007141">
        <property type="term" value="P:male meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035092">
        <property type="term" value="P:sperm DNA condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000002">
        <property type="entry name" value="Bromodomain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF175">
        <property type="entry name" value="BROMODOMAIN TESTIS-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="276"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="17">
        <location>
            <begin position="457"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="210"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="614" mass="69793" checksum="AC975B2607EC488C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIB4</accession>
    <name>A0A670IIB4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EGF like domain multiple 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EGFL6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nephronectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583523.1">
        <property type="nucleotide sequence ID" value="XM_028727690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IIB4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011838.1">
        <property type="protein sequence ID" value="ENSPMRP00000011082.1"/>
        <property type="gene ID" value="ENSPMRG00000007395.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596286"/>
    <dbReference type="CTD" id="25975"/>
    <dbReference type="GeneTree" id="ENSGT00930000150973"/>
    <dbReference type="OMA" id="NGRACID"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000187">
        <property type="entry name" value="nephronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000653">
        <property type="entry name" value="Putative Fibrillin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF24">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025690028" evidence="9">
        <location>
            <begin position="21"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="11">
        <location>
            <begin position="401"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="556" mass="61689" checksum="D431E3A56057720E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJI2</accession>
    <name>A0A670IJI2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Anosmin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ANOS1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the venom waprin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IJI2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012250.1">
        <property type="protein sequence ID" value="ENSPMRP00000011467.1"/>
        <property type="gene ID" value="ENSPMRG00000007671.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000033720"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anosmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001783">
        <property type="entry name" value="Anosmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.75.10:FF:000001">
        <property type="entry name" value="Anosmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042447">
        <property type="entry name" value="Anosmin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040957">
        <property type="entry name" value="Anosmin-1_Cys_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131">
        <property type="entry name" value="ANOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131:SF5">
        <property type="entry name" value="ANOSMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17869">
        <property type="entry name" value="Cys_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="WAP" evidence="15">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="224"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="330"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="588"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="717" mass="81620" checksum="9B8FB1B94BE601BA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IPP0</accession>
    <name>A0A670IPP0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane p24 trafficking protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TMED6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IPP0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014088.1">
        <property type="protein sequence ID" value="ENSPMRP00000013197.1"/>
        <property type="gene ID" value="ENSPMRG00000008835.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010961"/>
    <dbReference type="OMA" id="HNRFSTM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="43"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="231" mass="26597" checksum="6F38EBC3114A57F6" modified="2020-06-17" version="1">MSGYEELVPARFKSEPLSGSSDQPLFRGADQYNFGIVIPAGSIECFWQFAHQSGFFYFSYQVQWSSGLGHDQHILATANDPNGLHLGTSQDTRGQINFQTKETGFYQLCLSNRYNHFGSVQVYLNFGVFYEGFDLQTPQEAERKRLNDTLDAIEESTKKLLNGIFQMWRYYTFSRMKSTSDYFLLESNYNYVNWWSAAQSLAIVLSGVLQLYFLKRLFTTQPTTATNKPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQN4</accession>
    <name>A0A670IQN4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GPN2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IQN4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014974.1">
        <property type="protein sequence ID" value="ENSPMRP00000014011.1"/>
        <property type="gene ID" value="ENSPMRG00000009374.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183172"/>
    <dbReference type="OMA" id="ATHNYFL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="334" mass="37621" checksum="FF206652C34D8591" modified="2020-06-17" version="1">MSYSQKQSAVAFGQAVIGPPGSGKTTYCLGMQEFLSAIGRKVAVVNLDPANEGIPYQCAVDISELITLADVMENLKLGPNGGLIYCMEYLEANLDWLQEKLAQFKGHYFLFDCPGQVELCTHHSSLRNIFAQLAKWNFRLAAVHLVDSHYCTDPGKFISILCTSLSTMLHVELPHINVLSKMDLIEQYGKLAFNLDYYTEVLDLSYLVDHLATDPFFKNYQHLNKKLVEVIEDYSLVSFVPLNVQDKESMQRVMQAVDKANGYCFGDAEHRSLQALMSAAVGADFHFTSYPFFIVFPFPAARLSLIYASQEIIIWGNLHAHNYIAVLRVSLHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRW5</accession>
    <name>A0A670IRW5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Claspin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CLSPN</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="Ensembl" id="ENSPMRT00000015860.1">
        <property type="protein sequence ID" value="ENSPMRP00000014848.1"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:anaphase-promoting complex binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Claspin"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="863"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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                <person name="Carneiro M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        </cofactor>
        <cofactor evidence="1">
            <name>Cu cation</name>
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        </cofactor>
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    <comment type="PTM">
        <text evidence="1">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
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        <text evidence="1">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="222" mass="25546" checksum="29205C9360D092DA" modified="2020-06-17" version="1">MAFETVKAPWSPENKIHRMKIVRKVLDTENKAAFRLHDNMPRHIYFAANSTNKWGHKQGYRIQMVSFSGDHLRNRSMERAISWGRYKLAVTKRKEKEPFSTSIYNQMDPWTPSVAFADFLNNESIINEDLVAWITAGFLHIPHAEDIPNTPTLGNVIGFFLRPYNYFDDDPSMDSPDSVFFSSQQDPTSCDVNYLACMPKTAACLPSFPPFTYEGFQNMTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IT41</accession>
    <name>A0A670IT41_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IT41"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016188.1">
        <property type="protein sequence ID" value="ENSPMRP00000015150.1"/>
        <property type="gene ID" value="ENSPMRG00000010111.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031367">
        <property type="entry name" value="CCDC24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28601">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28601:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15669">
        <property type="entry name" value="CCDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="140" mass="15827" checksum="B5C6178D05B40275" modified="2020-06-17" version="1">MWQCTVPNAVQPLPYLQVRTLLELHQELQSGHLGVEQSPLQADDSWALLAAPPNLKELVREEIRLLLIGLQQKASQEGRYWRLEEKGLERIKAKITCAKHMFAPHTSICNVRSPFKSVELIPALHSHSLGLNHIAFVIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUE5</accession>
    <name>A0A670IUE5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Myosin VB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MYO5B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000015817.1">
        <property type="protein sequence ID" value="ENSPMRP00000014807.1"/>
        <property type="gene ID" value="ENSPMRG00000009756.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155402"/>
    <dbReference type="OMA" id="KVQDLEX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd15477">
        <property type="entry name" value="Myo5b_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000002">
        <property type="entry name" value="Class V myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000001">
        <property type="entry name" value="unconventional myosin-Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058662">
        <property type="entry name" value="Myo5a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037990">
        <property type="entry name" value="Myo5b_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF356">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25966">
        <property type="entry name" value="Myo5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="15">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="84"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="13">
        <location>
            <begin position="1339"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="10">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="907"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1088"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="714"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1146"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="917"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="979"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1094"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1661" mass="193343" checksum="E3BB279FC63242C9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IV79</accession>
    <name>A0A670IV79_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DCN1-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Defective in cullin neddylation protein 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DCUN1D5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of a complex that contains DCUN1D5, CUL1 and RBX1; this interaction is bridged by CUL1. Interacts (via the DCUN1 domain) with the unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5; these interactions promote the cullin neddylation and the identity of the cullin dictates the affinity of the interaction. Interacts (via DCUN1 domain) with UBE2M (N-terminally acetylated form) and probably with UBE2F (N-terminally acetylated form). May also interact with regulators or subunits of cullin-RING ligases such as RBX1, RNF7, ELOB and DDB1; these interactions are bridged by cullins. Interacts with CAND1; this interaction is bridged by cullins and strongly inhibits the neddylation of cullins. These CAND-cullin-DCNL complexes can only be neddylated in the presence of a substrate adapter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028582000.1">
        <property type="nucleotide sequence ID" value="XM_028726167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IV79"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016113.1">
        <property type="protein sequence ID" value="ENSPMRP00000015082.1"/>
        <property type="gene ID" value="ENSPMRG00000010069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595666"/>
    <dbReference type="KEGG" id="pmua:114595666"/>
    <dbReference type="CTD" id="84259"/>
    <dbReference type="GeneTree" id="ENSGT00940000156155"/>
    <dbReference type="OMA" id="HERKCKI"/>
    <dbReference type="OrthoDB" id="8989874at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000041">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000002">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF6">
        <property type="entry name" value="DCN1-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="10">
        <location>
            <begin position="44"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="234" mass="27211" checksum="D50059439213DA9C" modified="2020-06-17" version="1">MPVKKKRKSSGQAGDETGLKKCKISSYCRSQASSKVISGEEHFSSKKCLAWFYEYAGDDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEKLQSKFDFLRSQLNDISTFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVFYQYLEQSKYRVINKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWB1</accession>
    <name>A0A670IWB1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF217</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591062.1">
        <property type="nucleotide sequence ID" value="XM_028735229.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591063.1">
        <property type="nucleotide sequence ID" value="XM_028735230.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591064.1">
        <property type="nucleotide sequence ID" value="XM_028735231.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591065.1">
        <property type="nucleotide sequence ID" value="XM_028735232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IWB1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017165.1">
        <property type="protein sequence ID" value="ENSPMRP00000016081.1"/>
        <property type="gene ID" value="ENSPMRG00000010743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599652"/>
    <dbReference type="KEGG" id="pmua:114599652"/>
    <dbReference type="CTD" id="7764"/>
    <dbReference type="GeneTree" id="ENSGT00940000159884"/>
    <dbReference type="OMA" id="MEMDSKS"/>
    <dbReference type="OrthoDB" id="8953863at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001038">
        <property type="entry name" value="Zinc finger protein 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001201">
        <property type="entry name" value="Zinc finger protein 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001687">
        <property type="entry name" value="Zinc finger protein 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051967">
        <property type="entry name" value="Krueppel_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45925">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45925:SF4">
        <property type="entry name" value="ZINC FINGER PROTEIN 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="843"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116983" checksum="31C15FD4ACDC2A30" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWR6</accession>
    <name>A0A670IWR6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OR4A15</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IWR6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016667.1">
        <property type="protein sequence ID" value="ENSPMRP00000015607.1"/>
        <property type="gene ID" value="ENSPMRG00000010411.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163528"/>
    <dbReference type="OMA" id="TIMDWKV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15939">
        <property type="entry name" value="7tmA_OR4A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="304" mass="34146" checksum="09774E50D10DBBF0" modified="2020-06-17" version="1">MENRNNVSEFILLGLTPDPNIQKACFGLFLVFYTAIVLGNLLIIVTIKSSSRLNSPMYFFLSYLSFVDISYSSVTAPKMIADFLVEKKTISFVGCIIQLFFIHFFGGTEIFLLTSMAYDRYIAICKPLHYTTIMSKNVCGLMVAGSFLGGFLHSIVQTLLTIQLPFCGPNEIDHYFCDVHPLLKLACTNTYIVGLMVIANSGMISLTSFLVLAVSYISILVMLRTHSFEGRLKALSTCASHIAVVILYFGPCIFIYLRPPTTFSQDKSVALFYTIITPMLNPLIYTLRNEEVKNAMRKLWSKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXS8</accession>
    <name>A0A670IXS8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-acetyltaurine hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phosphotriesterase-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PTER</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-acetyl-L-isoleucine + H2O = L-isoleucine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:133735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:81120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-leucine + H2O = L-leucine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:58270"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:81116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-acetyl-L-methionine + H2O = L-methionine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:71670"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67441"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-L-valine + H2O = L-valine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81123"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:133716"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:81124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyltaurine + H2O = taurine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:133737"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:81108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-propanoyltaurine + H2O = propanoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:81111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:231795"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:81112"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605749.1">
        <property type="nucleotide sequence ID" value="XM_028749916.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028605750.1">
        <property type="nucleotide sequence ID" value="XM_028749917.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028605751.1">
        <property type="nucleotide sequence ID" value="XM_028749918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IXS8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017711.1">
        <property type="protein sequence ID" value="ENSPMRP00000016611.1"/>
        <property type="gene ID" value="ENSPMRG00000011053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607099"/>
    <dbReference type="KEGG" id="pmua:114607099"/>
    <dbReference type="CTD" id="9317"/>
    <dbReference type="GeneTree" id="ENSGT00390000006960"/>
    <dbReference type="OMA" id="MVKCGFI"/>
    <dbReference type="OrthoDB" id="9998343at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141215">
        <property type="term" value="F:N-acetyltaurine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032098">
        <property type="term" value="P:regulation of appetite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019530">
        <property type="term" value="P:taurine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00530">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819:SF3">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="349" mass="39211" checksum="36242B52799B1C04" modified="2020-06-17" version="1">MPSLKGKVQTVLGLVEPSQLGYTMTHEHLTMDYTCCYYPPPSGQEALSETSIEMKNLFWLKQNPYSHKENLLLHQETSAVKEELLQFKAAGGGTIVENTTTGIRRDMKTLKQLAEETGVHIIAGAGFYVGATHSPETRAMSVEQLTEVIVNEILNGADGTDIKCGVIGEVGCSWPLTESENKVLQATAHAQSQLGCPVIIHPGRNSDSPFQIIRILQEAGADTSKTVMSHMDRTIFDEKKLLEFAELGCYLEYDLFGTEFILYQMNPDIDMPSDNERILRVRMLIEEGYEDRVLLAHDMHTKNRLKKYGGHGYSHILENIVPKMLIRGISQEKIDKLLVGNPRRWLTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J0B7</accession>
    <name>A0A670J0B7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="12">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DUS4L</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,6-dihydrouridine(20a) in tRNA + NAD(+) = uridine(20a) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53348"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:53350"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(20a) in tRNA + NADP(+) = uridine(20a) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53344"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5,6-dihydrouridine(20b) in tRNA + NAD(+) = uridine(20b) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53352"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:53354"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5,6-dihydrouridine(20b) in tRNA + NADP(+) = uridine(20b) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53356"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:53358"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Dus family. Dus4 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A670J0B7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018786.1">
        <property type="protein sequence ID" value="ENSPMRP00000017645.1"/>
        <property type="gene ID" value="ENSPMRG00000011655.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074907"/>
    <dbReference type="OMA" id="QRPHHDI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102266">
        <property type="term" value="F:tRNA-dihydrouridine20a synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000100">
        <property type="entry name" value="tRNA-dihydrouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 12 14" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="15">
        <location>
            <begin position="42"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="329" mass="37285" checksum="888878EF637197C3" modified="2020-06-17" version="1">MFFVLQMWPDNFYVSSQSREILQCPLRNPVDLFHSETIVKICAPMVRYSKLPFRTLVRKYNCDLCYTPMIVAADFVRSVKARHSEFTTNQGDRPLIVQFAAKDAQVLADAACIISPFANGVDVNCGCPQRWAMAEGFGACLINKPELVQEMVRLVRNQVENPMFSVSIKIRIHDDLKRTVDLCQKAEAAGVSWITVHGRNVEERHQPVHYDAIKIIKQSMSIPVIANGDIKSLKDVKDVHQKTGTDGIMVARGLLANPAMFAGYEETPLRCLQDWVDIALEHGTPFACFHHHLMYMLERITSKQEKKVFNVLSSTSAVLDYLRNNYGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J213</accession>
    <name>A0A670J213_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 24 25">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="14 24 25">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">CDS2</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77126"/>
            <dbReference type="ChEBI" id="CHEBI:85351"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:45657"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45672"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77128"/>
            <dbReference type="ChEBI" id="CHEBI:85355"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:45673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:45677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:72864"/>
            <dbReference type="ChEBI" id="CHEBI:85350"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:45653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45668"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77130"/>
            <dbReference type="ChEBI" id="CHEBI:85354"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:45669"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:85349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:45649"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45660"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77098"/>
            <dbReference type="ChEBI" id="CHEBI:85352"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:45661"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45664"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74560"/>
            <dbReference type="ChEBI" id="CHEBI:85353"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:45665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16230"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 24 25">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 24 25">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="14 24 25"/>
    <dbReference type="RefSeq" id="XP_028597045.1">
        <property type="nucleotide sequence ID" value="XM_028741212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J213"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019703.1">
        <property type="protein sequence ID" value="ENSPMRP00000018538.1"/>
        <property type="gene ID" value="ENSPMRG00000012169.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000019707.1">
        <property type="protein sequence ID" value="ENSPMRP00000018542.1"/>
        <property type="gene ID" value="ENSPMRG00000012169.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602692"/>
    <dbReference type="KEGG" id="pmua:114602692"/>
    <dbReference type="CTD" id="8760"/>
    <dbReference type="GeneTree" id="ENSGT00940000158877"/>
    <dbReference type="OMA" id="IATHRYT"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF4">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 24" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="20 24" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="18 24 25" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22 24" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="23 24" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 24 25" id="KW-0808">Transferase</keyword>
    <keyword evidence="17 24 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000060"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00000281"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00000515"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00000859"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00001021"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00001056"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00001617"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00001729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00001902"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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        </source>
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        <source>
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        </source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="446" mass="51422" checksum="FD8720E4F3A6DFB1" modified="2020-06-17" version="1">MSELRQRLGRDADGQQQDSEGKESEFESKLDGETASDSESKSEIAQAAPVDDTPEVLNRALSNLSSRWKNWWVRGILTLAMIVFFFIIIYLGPMVLMMIVMCVQIKCFQEIITIGYNVYHSYELPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFALYLTGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLIIHNLFEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEFNNDTNSFTVDCEPPELFQLQEYNIPLVLQSVVGWKTVRMYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQLLTLRPDQQLNIFNTLKAHLVDKGMLAGSEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2Y6</accession>
    <name>A0A670J2Y6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Follistatin like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FSTL4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028573857.1">
        <property type="nucleotide sequence ID" value="XM_028718024.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000019012.1">
        <property type="protein sequence ID" value="ENSPMRP00000017864.1"/>
        <property type="gene ID" value="ENSPMRG00000011789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591264"/>
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    <dbReference type="CTD" id="23105"/>
    <dbReference type="GeneTree" id="ENSGT00940000158076"/>
    <dbReference type="OMA" id="RYLPVCG"/>
    <dbReference type="OrthoDB" id="6085115at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:secretory granule"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:brain-derived neurotrophic factor binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031549">
        <property type="term" value="P:negative regulation of brain-derived neurotrophic factor receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of collateral sprouting"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig"/>
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        <property type="entry name" value="IgI_2_Follistatin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Follistatin like 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000007">
        <property type="entry name" value="follistatin-related protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KAZAL_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        </location>
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            <begin position="81"/>
            <end position="135"/>
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            <begin position="172"/>
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            <begin position="250"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    <sequence length="839" mass="95446" checksum="35E02DA8AF4D7E5F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J310</accession>
    <name>A0A670J310_PODMU</name>
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        <recommendedName>
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        </recommendedName>
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        <name evidence="10" type="primary">LOC114603146</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
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        </subcellularLocation>
        <subcellularLocation>
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    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
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        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="213" mass="23187" checksum="AF9AE7C40618B69B" modified="2020-06-17" version="1">MGLTTSLLSIFLGAFSFVCTVGAICTDCWQVNSKGSVVLSMRCRGLWGECVWDKFVKIWTCDVFSSYLNPHPGAIIIARASLITSAIAGAAAFICLLSGCPYFRCFQEATAKWRCLCLSTGCYLFAGFLSCIGVIRYCLYVFFQHQYEVSLSIPGFPSFEYGYSLWMAVAGGLAAIAAAVMSYYEGVLLKTFSMSPAKEMPAGDATGTTWTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3D8</accession>
    <name>A0A670J3D8_PODMU</name>
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        <recommendedName>
            <fullName evidence="3">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:ruffle membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
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        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF338">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025347719" description="SEC7 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="49"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="320" mass="35133" checksum="D4F519BF916DC4CC" modified="2020-06-17" version="1">MCDLNILLLPSCCVVIIAFLSCSRPEEPPSGKGTDSGGETPPAKEEQAEPNGILHANGSAPPADQAAAARLAARLYHLDGFKRSQVASFLRKNNDFSRLVREAYLSFFQFSGQTLDQALRSFLKAFVLTGETQERERILRHFSERYHSCNPEVCFSPDAVHTLTCAIMLLNTDLHGQNIGRSMTCQAFLTNLDGLNDGKNFPKEQLKVQRRGSPFPLSWGGGETGGLAWLGSVRELPSAQRREMEGQLCYREPPKILRSSSSSGEEESPTSSGEEVQGPGNARESLNTEPEQTREVGSTPLPAPILRSSLWRREGQKGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J411</accession>
    <name>A0A670J411_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G protein-activated inward rectifier potassium channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inward rectifier K(+) channel Kir3.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium channel, inwardly rectifying subfamily J member 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J411"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020172.1">
        <property type="protein sequence ID" value="ENSPMRP00000018996.1"/>
        <property type="gene ID" value="ENSPMRG00000012411.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01080000257365"/>
    <dbReference type="OMA" id="PRWEECK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015467">
        <property type="term" value="F:G-protein activated inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000019">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000006">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003274">
        <property type="entry name" value="K_chnl_inward-rec_Kir3.1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF99">
        <property type="entry name" value="G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01327">
        <property type="entry name" value="KIR31CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 17" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 17" id="KW-0813">Transport</keyword>
    <keyword evidence="7 17" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="19">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="20">
        <location>
            <begin position="177"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="16">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="323" mass="36610" checksum="36B4C2A241A19639" modified="2020-06-17" version="1">MSVVRRKFGDEYQAVVGTSARRKRQRFVDKNGRCNVQHGNLGSENSRYLTDLFTTLVDLKWRWNLLIFLLTYTVAWLVMASMWWGIAYLRGDLDMHHGHSPGHNPCVANVYNFPSAFLFFIETEATIGYGHRYITERCPEGIVLFLFQSLLGSVVDAFLIGCMFIKMSQPKKRAETLMFSRAAVISKRDGKLCLMFRVGNLRNSHMVSAQIRCKLIKSRQTPEGEFLPLDQCELDVGFGTGADQLFLVSPLTICHEINEKSPFFALSQRSLRSEQFEIVVILEGIVETTGTVLTNNNNNNNLHSAKMGAPVGFQVLPEYISHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J508</accession>
    <name>A0A670J508_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COMM domain containing 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">COMMD8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028599929.1">
        <property type="nucleotide sequence ID" value="XM_028744096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J508"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019515.1">
        <property type="protein sequence ID" value="ENSPMRP00000018352.1"/>
        <property type="gene ID" value="ENSPMRG00000012073.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604197"/>
    <dbReference type="KEGG" id="pmua:114604197"/>
    <dbReference type="CTD" id="54951"/>
    <dbReference type="GeneTree" id="ENSGT00390000018121"/>
    <dbReference type="OMA" id="KLCHRVV"/>
    <dbReference type="OrthoDB" id="17646at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04756">
        <property type="entry name" value="Commd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047235">
        <property type="entry name" value="COMMD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055184">
        <property type="entry name" value="COMMD8_HN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22838">
        <property type="entry name" value="COMMD8_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="108"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="175" mass="20145" checksum="1D233292AE24B9FF" modified="2020-06-17" version="1">MKLTEKLPAEERLKFFHKVIDGICGRAYPRYQDYNTIWNLTEWMEVLEQTSAYFKSTVAKDRSDEEALQPLDELSSDTQKAVVTCLKGRKHDIRHALIERTNGICSARLLDFDWQLKLALSSDKLSMLQMPLLNLDLDLAENGNLKPYSIEMNKEELQNLISSLEAANKVVLQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5S1</accession>
    <name>A0A670J5S1_PODMU</name>
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        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Chromosome 13"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="506"/>
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    </feature>
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        <location>
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            <end position="545"/>
        </location>
    </feature>
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        <location>
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            <end position="594"/>
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    </feature>
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        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
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        <location>
            <begin position="638"/>
            <end position="661"/>
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        <location>
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            <end position="676"/>
        </location>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019858.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="677" mass="76293" checksum="73DACA4377018FCE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J6I0</accession>
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        <submittedName>
            <fullName evidence="7">SET binding factor 1</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="entry name" value="dDENN_dom"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="6">
        <location>
            <begin position="1132"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1833"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1793"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1288"/>
        </location>
    </feature>
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        <location>
            <begin position="1793"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1816"/>
            <end position="1828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1940" mass="217341" checksum="6AF3F85AB548A075" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JA10</accession>
    <name>A0A670JA10_PODMU</name>
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        <recommendedName>
            <fullName evidence="1">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="101" mass="11034" checksum="116C20FFB6E0B399" modified="2020-06-17" version="1">LNPFCESGPGFFEDVAVCFIDEEGVLLDPDQTALRKEVMEENCGRMDSLGKAPCSSMISVLKCNIPTKASVILTLPQLTLNDLCAHILPPAVPFKTRNRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBL9</accession>
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        <recommendedName>
            <fullName evidence="5 11">UDP-glucose 6-dehydrogenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">UGDH</name>
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    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 11"/>
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        <property type="nucleotide sequence ID" value="XM_028745251.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028745252.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000022957.1">
        <property type="protein sequence ID" value="ENSPMRP00000021635.1"/>
        <property type="gene ID" value="ENSPMRG00000014040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604768"/>
    <dbReference type="KEGG" id="pmua:114604768"/>
    <dbReference type="CTD" id="7358"/>
    <dbReference type="GeneTree" id="ENSGT00390000015355"/>
    <dbReference type="OMA" id="CFIAVGT"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001702">
        <property type="term" value="P:gastrulation with mouth forming second"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:neuron development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF59">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="332"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="161"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="220"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="267"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="494" mass="55018" checksum="52BD9856C1134006" modified="2020-06-17" version="1">MFEIKKICCIGAGYVGGPTCSVIAHMCPKIKVTVVDVNEARINAWNSDTLPIYEPGLKEVVESCRGKNLFFSTSIDDAIRDADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPDLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQKAVRALCAVYEQWVPKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVARAIGMDQRIGSKFLKASVGFGGSCFQKDVLNLVYLCEALNLSEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVLKEQIILDLSHPGVSEDDQVSRLVTISKDPYEACDGAHALVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDDLHNELQGIGFQIETIGKKVSAKRIPFASSCDIPKFSLQDPPLKKPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFS3</accession>
    <name>A0A670JFS3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Integrin subunit alpha 2b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ITGA2B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JFS3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024343.1">
        <property type="protein sequence ID" value="ENSPMRP00000022915.1"/>
        <property type="gene ID" value="ENSPMRG00000014873.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160724"/>
    <dbReference type="OMA" id="CFNIDIC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070442">
        <property type="term" value="C:integrin alphaIIb-beta3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF73">
        <property type="entry name" value="INTEGRIN ALPHA-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025705735" evidence="13">
        <location>
            <begin position="34"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="244"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="14">
        <location>
            <begin position="460"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="560"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="667" mass="72958" checksum="AA858CC0CD80ED61" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JGZ3</accession>
    <name>A0A670JGZ3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TAFA chemokine like family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TAFA2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAFA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JGZ3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025168.1">
        <property type="protein sequence ID" value="ENSPMRP00000023716.1"/>
        <property type="gene ID" value="ENSPMRG00000015353.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161214"/>
    <dbReference type="OMA" id="VEMEIHR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="131" mass="14564" checksum="DA941DCEE24EECBC" modified="2020-06-17" version="1">MNKRYLQKATKGKLLIIIFVVTLWGRIASGANHHKAHHVKTGTCEVVALHRCCNKNKIEERSQTVKCSCFPGQVAGTTRAAPSCVDASIVEQKWWCHMQPCLEGEECKVLPDRKGWSCSSGNKVKTTRANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JI53</accession>
    <name>A0A670JI53_PODMU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="15" type="primary">LRIG3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028601906.1">
        <property type="nucleotide sequence ID" value="XM_028746073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JI53"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025109.1">
        <property type="protein sequence ID" value="ENSPMRP00000023660.1"/>
        <property type="gene ID" value="ENSPMRG00000015318.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605161"/>
    <dbReference type="KEGG" id="pmua:114605161"/>
    <dbReference type="CTD" id="121227"/>
    <dbReference type="GeneTree" id="ENSGT00940000157098"/>
    <dbReference type="OMA" id="WIIEDQS"/>
    <dbReference type="OrthoDB" id="5917255at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032474">
        <property type="term" value="P:otolith morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="IgI_LRIG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF16">
        <property type="entry name" value="LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="829"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="523"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="627"/>
            <end position="716"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="721"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="1088"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1110"/>
            <end position="1121"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127067" checksum="3800FC502081F41E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JIS0</accession>
    <name>A0A670JIS0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JIS0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026214.1">
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        <property type="gene ID" value="ENSPMRG00000015966.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="369" mass="41352" checksum="183536096DC3E7C0" modified="2020-06-17" version="1">MEGSYKPTTTLLLLLLFSRVRLFVTPWTRARQALLSSTASRSLVKLMLVASRTLSNYLFLCHPLLLVPSIFPNIRVFSRESSLLMRWPKSWSLSFRICPSSEHSGLISLRMERFDLLAIHGTLKSLLQHHNSKASILWQSAFFMVQLSLPYITTGKTMALTIQTFVGKVMPLLFKMLSRFVTAFLPRSRRLLISWLLSPSAVIMEPKKVKSLTASISSPSICQEVMGPLQHREGQIMSRRTHKHSVVVGLTGTFLPSFHPPVHKFGFRCSSKCCCSGFQQLHFKVPYNSQSAFHSHGACSVGCGGGSLLRISPLILFVFFLYFFKPWESSMPATALKALTSEIENIIYLLVAADGGGSRSLNRKLSVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JIW9</accession>
    <name>A0A670JIW9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GJC1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the connexin family. Gamma-type subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028558829.1">
        <property type="nucleotide sequence ID" value="XM_028702996.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028558830.1">
        <property type="nucleotide sequence ID" value="XM_028702997.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028558831.1">
        <property type="nucleotide sequence ID" value="XM_028702998.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028558832.1">
        <property type="nucleotide sequence ID" value="XM_028702999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JIW9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024380.1">
        <property type="protein sequence ID" value="ENSPMRP00000022952.1"/>
        <property type="gene ID" value="ENSPMRG00000014902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582189"/>
    <dbReference type="KEGG" id="pmua:114582189"/>
    <dbReference type="CTD" id="10052"/>
    <dbReference type="GeneTree" id="ENSGT01150000286949"/>
    <dbReference type="OMA" id="VRWKQHR"/>
    <dbReference type="OrthoDB" id="8875898at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086077">
        <property type="term" value="F:gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048738">
        <property type="term" value="P:cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016264">
        <property type="term" value="P:gap junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.80:FF:000003">
        <property type="entry name" value="Gap junction protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002265">
        <property type="entry name" value="Connexin45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF6">
        <property type="entry name" value="GAP JUNCTION GAMMA-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01136">
        <property type="entry name" value="CONNEXINA6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0303">Gap junction</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="14">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="15">
        <location>
            <begin position="186"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="391" mass="45139" checksum="CDDC8F0EC24BDFC3" modified="2020-06-17" version="1">MSWSFLTRLLEEIHNHSTFVGKIWLTLLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVSTPSVMYLAYAIHKIARMVEHGETERKFRSKPFPMRWKQHRGLEEAEDDHEEDPMMYPEIELESENKENPPPTKVKHDGRRRIREDGLMKIYILQLLSRTVFEIGFLVGQYFLYGFEVSPRFLCSRKPCPHTIDCFISRPTEKTIFLLIMYGVSCLCLLLNVWEMLHLGFGTIRDTLNNKQKELEDSGTYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKMAYKQNKANIAQEQQYGSNEENIPTELETLQQEIKVAQERLDLAIQAYNNQNNPTCSKEKKPKASSNKSSGSSKSGDGKTSVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JK45</accession>
    <name>A0A670JK45_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein Rlf-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114603587</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598549.1">
        <property type="nucleotide sequence ID" value="XM_028742716.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000024788.1">
        <property type="protein sequence ID" value="ENSPMRP00000023347.1"/>
        <property type="gene ID" value="ENSPMRG00000015156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603587"/>
    <dbReference type="KEGG" id="pmua:114603587"/>
    <dbReference type="GeneTree" id="ENSGT00950000183034"/>
    <dbReference type="OMA" id="SMFQHRY"/>
    <dbReference type="OrthoDB" id="8691423at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052251">
        <property type="entry name" value="GH-ZnFinger_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057986">
        <property type="entry name" value="TPR_Rlf/292/654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058902">
        <property type="entry name" value="zf_C2H2_ZNF292/Rlf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15507">
        <property type="entry name" value="ZINC FINGER PROTEIN RLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15507:SF18">
        <property type="entry name" value="ZINC FINGER PROTEIN RLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25580">
        <property type="entry name" value="TPR_Rlf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25420">
        <property type="entry name" value="zf-C2H2_ZN292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26218">
        <property type="entry name" value="zf_C2H2_ZNF292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
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</entry>
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        <scope>IDENTIFICATION</scope>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of MAPK cascade"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042053">
        <property type="term" value="P:regulation of dopamine metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046883">
        <property type="term" value="P:regulation of hormone secretion"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014062">
        <property type="term" value="P:regulation of serotonin secretion"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0019229">
        <property type="term" value="P:regulation of vasoconstriction"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:serotonin metabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:serotonin receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000610">
        <property type="entry name" value="5HT1A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF191">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00512">
        <property type="entry name" value="5HT1ARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0085">Behavior</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022610"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="443" mass="48469" checksum="77F52CD6756A76F3" modified="2020-06-17" version="1">MEMPNSTTAANGSQPTSPAPAATLGYQLGTSVVLGALILFAVVGNACVIAAIALERTLQTVANYLIGSLAVTDLMVSVLVLPMAALYQVLGKWTLGQVTCDIFNSLDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFLISIPPMLGWRTPEDRADPNACTISKDPGYTIYSTFGAFYIPLLLMLVLYGRIFKAARFRIRKTVKKADKKQQQQHEDSEKVADTCLSASPSSGEPKRSNGGPQQQPKSWKSAVEPKGPEGPCVNGALRLGEDGPVAALEILEVNPSNSTKSHLPLPNHHHHHHHHHHHHHPPPQGSSGAATPSTERKNEPKNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPLCGSGCYMPDWLGAVINWLGYSNSLLNPVIYAYFNKDFQSAFKKIIKCKFCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNZ4</accession>
    <name>A0A670JNZ4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycogen synthase kinase-3 beta</fullName>
            <ecNumber evidence="5">2.7.11.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">GSK3B</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12801"/>
            <dbReference type="Rhea" id="RHEA-COMP:13701"/>
            <dbReference type="Rhea" id="RHEA-COMP:13702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53904"/>
            <dbReference type="Rhea" id="RHEA-COMP:13703"/>
            <dbReference type="Rhea" id="RHEA-COMP:13704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.26" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028567886.1">
        <property type="nucleotide sequence ID" value="XM_028712053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JNZ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027736.1">
        <property type="protein sequence ID" value="ENSPMRP00000026136.1"/>
        <property type="gene ID" value="ENSPMRG00000016914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587589"/>
    <dbReference type="KEGG" id="pmua:114587589"/>
    <dbReference type="CTD" id="2932"/>
    <dbReference type="GeneTree" id="ENSGT00520000055635"/>
    <dbReference type="OMA" id="MKTTMPM"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001837">
        <property type="term" value="P:epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006983">
        <property type="term" value="P:ER overload response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070885">
        <property type="term" value="P:negative regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
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        <property type="term" value="P:negative regulation of mesenchymal stem cell differentiation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </evidence>
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    </evidence>
    <sequence length="433" mass="48054" checksum="FED8637488D7CF83" modified="2020-06-17" version="1">MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMIFVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNIKLPSGREKPALFNFTTQELSSNPSLASTLIPAHARSQAAASTPTNVPAASDANAGDRVQTNNVASASASNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JP21</accession>
    <name>A0A670JP21_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DAB adaptor protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DAB2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JP21"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027213.1">
        <property type="protein sequence ID" value="ENSPMRP00000025635.1"/>
        <property type="gene ID" value="ENSPMRG00000016609.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155567"/>
    <dbReference type="OMA" id="FMSHEPI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:clathrin-coated vesicle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038024">
        <property type="term" value="F:cargo receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035026">
        <property type="term" value="P:leading edge cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060766">
        <property type="term" value="P:negative regulation of androgen receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="251" mass="25831" checksum="BA9AF6BD3E1EEB32" modified="2020-06-17" version="1">MAAGDGAGAAAAAAASPSSRRRCPSHCISALIQLNHTRRGPALEDCDCDQDENCRATKRAIEPCLPRTSGGGGGGGGAGGGVGAGGVIGCTEARRRCDWDSRCSAALGRYMTYCGKVFNGVRCTEDCRAVIEDMLAVPKALLLNDCVCDGLERPICESVKENMARLCFGADAVGPGSSGASDGAMDDYWEEEYDEELAPRGRDDLDDVAAVAGAGSEAASPRKPKDGCPARSAPWTLGATASILLLLLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSE5</accession>
    <name>A0A670JSE5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Toll-like receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114586776</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566410.1">
        <property type="nucleotide sequence ID" value="XM_028710577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JSE5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028045.1">
        <property type="protein sequence ID" value="ENSPMRP00000026434.1"/>
        <property type="gene ID" value="ENSPMRG00000017097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586776"/>
    <dbReference type="KEGG" id="pmua:114586776"/>
    <dbReference type="GeneTree" id="ENSGT00940000164422"/>
    <dbReference type="OMA" id="CSDAEWV"/>
    <dbReference type="OrthoDB" id="1081807at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000046">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017241">
        <property type="entry name" value="Toll-like_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF26">
        <property type="entry name" value="TOLL-LIKE RECEPTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037595">
        <property type="entry name" value="Toll-like_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0391">Immunity</keyword>
    <keyword evidence="14 15" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3 15" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025644196" evidence="19">
        <location>
            <begin position="20"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="20">
        <location>
            <begin position="648"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="795"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037595-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="830" mass="94233" checksum="B87E2A2C9C27A477" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTZ4</accession>
    <name>A0A670JTZ4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPX8</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028604893.1">
        <property type="nucleotide sequence ID" value="XM_028749060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JTZ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027936.1">
        <property type="protein sequence ID" value="ENSPMRP00000026332.1"/>
        <property type="gene ID" value="ENSPMRG00000017037.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000027939.1">
        <property type="protein sequence ID" value="ENSPMRP00000026335.1"/>
        <property type="gene ID" value="ENSPMRG00000017037.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000027944.1">
        <property type="protein sequence ID" value="ENSPMRP00000026339.1"/>
        <property type="gene ID" value="ENSPMRG00000017037.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000027946.1">
        <property type="protein sequence ID" value="ENSPMRP00000026342.1"/>
        <property type="gene ID" value="ENSPMRG00000017037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606622"/>
    <dbReference type="KEGG" id="pmua:114606622"/>
    <dbReference type="CTD" id="493869"/>
    <dbReference type="GeneTree" id="ENSGT00940000159371"/>
    <dbReference type="OMA" id="PTWNFCK"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000049">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013376">
        <property type="entry name" value="Glut_perox_Gpx7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02540">
        <property type="entry name" value="gpx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF7">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="44"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="212" mass="24663" checksum="70E6F7D0158B4670" modified="2020-06-17" version="1">MEPPLPLPLTACSLKSSRLKTRVLIIFFSMVLFTAILGLLQLKYLKPKDFYSFEVMDPKGRTVSLEKYRGKASLVVNVASYCQHTEKNYIMLQELHREFGPYHFTVLAFPCNQYGEMEPDTSRRIEYLAKSNYRVTFPIFKKIKILGSEASPAFQFLIDSSKAMPRWNFWKYLINPDGKVVKFWGPEEPIESIKPDIAALVRQIILKRREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUY5</accession>
    <name>A0A670JUY5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lens fiber membrane intrinsic protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114587136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PMP-22/EMP/MP20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566927.1">
        <property type="nucleotide sequence ID" value="XM_028711094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JUY5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028255.1">
        <property type="protein sequence ID" value="ENSPMRP00000026637.1"/>
        <property type="gene ID" value="ENSPMRG00000017215.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587136"/>
    <dbReference type="KEGG" id="pmua:114587136"/>
    <dbReference type="GeneTree" id="ENSGT01050000244814"/>
    <dbReference type="OMA" id="QLCAYRQ"/>
    <dbReference type="OrthoDB" id="6137544at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000011">
        <property type="entry name" value="lens fiber membrane intrinsic protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003935">
        <property type="entry name" value="LMIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004032">
        <property type="entry name" value="PMP22_EMP_MP20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF106">
        <property type="entry name" value="LENS INTRINSIC MEMBRANE PROTEIN 2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01457">
        <property type="entry name" value="LENSMEMPROT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01221">
        <property type="entry name" value="PMP22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="172" mass="18600" checksum="30D0E798E021D201" modified="2020-06-17" version="1">MFNLMGGGLLCAASGLVLLIVATATDFWMQYRYSGNLSNQGLWRFCVGNKCHPHTITLAFWDATRAFMLLSILSSFAGIILGLTIYSSSARSTRTRSAGITLLIAGLFALLGISVYTGVTVSFYGKRYAEWRFSWSYILGWIAVILTISAGVFHICAVPRNSSSDGSDVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUZ4</accession>
    <name>A0A670JUZ4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JUZ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029405.1">
        <property type="protein sequence ID" value="ENSPMRP00000027720.1"/>
        <property type="gene ID" value="ENSPMRG00000017887.1"/>
    </dbReference>
    <dbReference type="OMA" id="QVSPACE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="59" mass="6147" checksum="F4BCE21BFF3C904B" modified="2020-06-17" version="1">SPIFGPLSLSGGSIIMAAVMSLGKIAENGTAPSQNAKSPPKPLAPNWTGRRNQEKKDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVQ5</accession>
    <name>A0A670JVQ5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-enolase</fullName>
            <ecNumber evidence="5">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Beta-enolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Phosphopyruvate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ENO3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:10165"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="5"/>
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    <dbReference type="Ensembl" id="ENSPMRT00000030275.1">
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</entry>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYD7</accession>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Salvi D."/>
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                <person name="While G.M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the eIF4E-binding protein family.</text>
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        <property type="protein sequence ID" value="ENSPMRP00000028850.1"/>
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
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        <property type="term" value="F:translation repressor activity"/>
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        <property type="term" value="P:cellular response to dexamethasone stimulus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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        <property type="term" value="P:insulin receptor signaling pathway"/>
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        <property type="term" value="P:IRES-dependent translational initiation of linear mRNA"/>
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        <property type="term" value="P:negative regulation of translational initiation"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1"/>
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        <property type="entry name" value="eIF_4EBP"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0652">Protein synthesis inhibitor</keyword>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="123" mass="12899" checksum="C11BDA7F252755B3" modified="2020-06-17" version="1">MSAASCCRPHPPQGPTLGRDIPGPAKRLILPDGAALPPGDYSTTPGGTLFGTTPGGTRIIYDRKFLMECRNSPVAKTPPCDLPDIPGVTSPAVEILGTETNLSHAEEEKQPGSGEEAQFDMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K085</accession>
    <name>A0A670K085_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain containing 122</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K085"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032832.1">
        <property type="protein sequence ID" value="ENSPMRP00000030953.1"/>
        <property type="gene ID" value="ENSPMRG00000020054.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005130"/>
    <dbReference type="OMA" id="FMTELYE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="240" mass="28150" checksum="5A8C6BE6753371CA" modified="2020-06-17" version="1">MKGQQQKNKIILFNLINWKLQDLEAQMKLVVADRKATERQMFHQDEAIISTKDHCENLEVQITALYAENLKLAFDTETLQEEYKLMLQRNSAYYAKMAAHRDHFVEAENKLPLMTELTKKRAAVKEMITNKEELMSVLQNPEVPVNTTNQSQDEIVYLEAEINALKEAISGKENALREERNAHARLRKEIQVQNKRYEAILKRLHCQVNKFQSSKRQRHCNLQQMEEKVAELRNLLEATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K089</accession>
    <name>A0A670K089_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-X-C chemokine receptor type 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">High affinity interleukin-8 receptor B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with IL8. Interacts with GNAI2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K089"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030757.1">
        <property type="protein sequence ID" value="ENSPMRP00000028989.1"/>
        <property type="gene ID" value="ENSPMRG00000018745.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244848"/>
    <dbReference type="OMA" id="SPVCYEV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016494">
        <property type="term" value="F:C-X-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15178">
        <property type="entry name" value="7tmA_CXCR1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000174">
        <property type="entry name" value="Chemokine_CXCR_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF689">
        <property type="entry name" value="C-X-C CHEMOKINE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00427">
        <property type="entry name" value="INTRLEUKIN8R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="60"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="351" mass="39429" checksum="88245E5394B92527" modified="2020-06-17" version="1">IAQYNMDSKDANYSDYDYYGTFNPNSVAAKAPCGIDVMPPVFKYLVAFIYGLTCLLSLVGNSLVVLVIAYSKGNRSVTDVYLLNLAIADLLFALTLPFWAVDRAHEWIFGTPMCKILSLLKEVNFYSGILLLAGISMDRYLAIVHAIRAVTQKRSWVRFVCVGIWLLSFLLSLPVIIFHEAFLPTEEMKWVCHEYIGWNQISGIRAKLRILPQTFGFILPLIIMLFCYGVTVHRLYQTKNSPKKKAMKVILAVVLVFLVCWLPYNISLLLDTLMRSGAIGETCDLRNSIDTALSGTEILGFAHSCVNPIIYASIGQKFRNNFLKILVTRGIISKEALTRFRKGSSFSSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0N5</accession>
    <name>A0A670K0N5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670K1T8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033413.1">
        <property type="protein sequence ID" value="ENSPMRP00000031498.1"/>
        <property type="gene ID" value="ENSPMRG00000020408.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189322"/>
    <dbReference type="OMA" id="NICDQDR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF27">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="206" mass="24016" checksum="3DF9426CE9D0345C" modified="2020-06-17" version="1">TNRQTGPMSLTLLTWNVNGLNEKSKRNKIEKVLRNKKCDVICCQETHVAKKHKHILVNKKLGVEFINSEVNKKRGLVIYVKEKLEPKLIYKDEEGRILGVQITHQGERINVVSIYAPNTNQIEFYRKLEQVLLELENHNLIVLGDMNGVPEPEIDRSEKKRKRNQGKLPKTFDDLQENLDLIDIWRFKNPTEKQFTHFSGQYLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K352</accession>
    <name>A0A670K352_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UBE2D2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670K352"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031895.1">
        <property type="protein sequence ID" value="ENSPMRP00000030079.1"/>
        <property type="gene ID" value="ENSPMRG00000019454.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153169"/>
    <dbReference type="OMA" id="PNIASMY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="126" mass="14592" checksum="C34652C78C0A771A" modified="2020-06-17" version="1">MIWHVILQHSVQQGLLEMINDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5G9</accession>
    <name>A0A670K5G9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Apoptosis-inducing factor 1, mitochondrial</fullName>
            <ecNumber evidence="8">1.4.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Programmed cell death protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">AIFM1</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="27">Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>A + NADH + H(+) = AH2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11356"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="28">Monomer (oxidized form). Homodimer (reduced form). Upon reduction with NADH, undergoes dimerization and forms tight, long-lived FADH2-NAD charge transfer complexes (CTC) resistant to oxidation. Also dimerizes with isoform 3 preventing its release from mitochondria. Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus). Interacts with PRELID1. Interacts with CHCHD4; the interaction increases in presence of NADH. Interacts with processed form of PARP1 (Poly [ADP-ribose] polymerase 1, processed C-terminus); interaction is mediated with poly-ADP-ribose chains attached to PARP1, promoting translocation into the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the flavin monoamine oxidase family. FIG1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028570579.1">
        <property type="nucleotide sequence ID" value="XM_028714746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K5G9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034021.1">
        <property type="protein sequence ID" value="ENSPMRP00000032081.1"/>
        <property type="gene ID" value="ENSPMRG00000020802.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588939"/>
    <dbReference type="KEGG" id="pmua:114588939"/>
    <dbReference type="CTD" id="9131"/>
    <dbReference type="GeneTree" id="ENSGT00940000156455"/>
    <dbReference type="OMA" id="RSIFFEH"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000007">
        <property type="entry name" value="Putative apoptosis-inducing factor 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029324">
        <property type="entry name" value="AIF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14721">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01353">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0274">FAD</keyword>
    <keyword evidence="12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="24" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="23" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-0520">NAD</keyword>
    <keyword evidence="25" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="32">
        <location>
            <begin position="133"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial apoptosis-inducing factor C-terminal" evidence="33">
        <location>
            <begin position="462"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="509"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00055744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00062987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00067295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00078456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF14721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="610" mass="66927" checksum="88392FC6DB38DC3A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K658</accession>
    <name>A0A670K658_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450 2D6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114605492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028602669.1">
        <property type="nucleotide sequence ID" value="XM_028746836.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000033004.1">
        <property type="protein sequence ID" value="ENSPMRP00000031114.1"/>
        <property type="gene ID" value="ENSPMRG00000020163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605492"/>
    <dbReference type="KEGG" id="pmua:114605492"/>
    <dbReference type="GeneTree" id="ENSGT00940000153331"/>
    <dbReference type="OMA" id="RAWERPT"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K684</accession>
    <name>A0A670K684_PODMU</name>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <location>
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            <end position="16"/>
        </location>
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            <begin position="17"/>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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            <dbReference type="PROSITE" id="PS51041"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031134.1"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="94586" checksum="F3FC8BF820FFEE3A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6Q0</accession>
    <name>A0A670K6Q0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Sterol regulatory element-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Sterol regulatory element-binding transcription factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">SREBF2</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Laterata</taxon>
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        </lineage>
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    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">COPII-coated vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the SREBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028601261.1">
        <property type="nucleotide sequence ID" value="XM_028745428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K6Q0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033203.1">
        <property type="protein sequence ID" value="ENSPMRP00000031304.1"/>
        <property type="gene ID" value="ENSPMRG00000020292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604891"/>
    <dbReference type="KEGG" id="pmua:114604891"/>
    <dbReference type="CTD" id="6721"/>
    <dbReference type="GeneTree" id="ENSGT00940000157339"/>
    <dbReference type="OMA" id="QQAVMIT"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032937">
        <property type="term" value="C:SREBP-SCAP-Insig complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071404">
        <property type="term" value="P:cellular response to low-density lipoprotein particle stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900222">
        <property type="term" value="P:negative regulation of amyloid-beta clearance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090370">
        <property type="term" value="P:negative regulation of cholesterol efflux"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045542">
        <property type="term" value="P:positive regulation of cholesterol biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010886">
        <property type="term" value="P:positive regulation of cholesterol storage"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902895">
        <property type="term" value="P:positive regulation of miRNA transcription"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18922">
        <property type="entry name" value="bHLHzip_SREBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000016">
        <property type="entry name" value="Sterol regulatory element-binding transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062:SF3">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BHLH" evidence="25">
        <location>
            <begin position="308"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00039750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1119" mass="121949" checksum="867CC284B50BE6EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7Z7</accession>
    <name>A0A670K7Z7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K7Z7"/>
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        <property type="protein sequence ID" value="ENSPMRP00000032440.1"/>
        <property type="gene ID" value="ENSPMRG00000021017.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161439"/>
    <dbReference type="OMA" id="CGRIAML"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000264">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="260" mass="28672" checksum="35B112C5DF6FC3ED" modified="2020-06-17" version="1">SWLPLLGPWVSIRNLVKIYSSGGKIAVNGLSLDFYEGQITSFLGHNGAGKTTTMSILTGLLDICSDMDIIRRTMGVCPQHNVLFDILTVEEHIWFYGRLKGLSGVQVREEMEQIIQDVGLPHKRRDQTKNLSGGMQRKLSVAIAFVGGSKVVILDEPTAGVDPYSRRGIWDLLLKYRTGRTVILSTHYMDEADLLGDRVAIISQGRLCCCGSSLFLKTKLGTGYYLTLVKREAGRGLGKEPCLRLNPAQGKDPVKVTVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K810</accession>
    <name>A0A670K810_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MINDY1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MINDY deubiquitinase family. FAM63 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A670K810"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034414.1">
        <property type="protein sequence ID" value="ENSPMRP00000032455.1"/>
        <property type="gene ID" value="ENSPMRG00000021029.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016607"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140934">
        <property type="term" value="F:histone deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF7">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="9">
        <location>
            <begin position="141"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="567" mass="61616" checksum="74A42A379AE29D76" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8J1</accession>
    <name>A0A670K8J1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K8J1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034628.1">
        <property type="protein sequence ID" value="ENSPMRP00000032655.1"/>
        <property type="gene ID" value="ENSPMRG00000021159.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="112" mass="12354" checksum="A4001DB01EB0CE12" modified="2025-10-08" version="2">MWFLKTLDLTLIRLGAVTRTTNGSSGLQPWLVGLAAVLGFLGVIFVVSLSQLEWDPKKPSSPTPSAPLSPLTTLFSLQGWRREVDEHRPSVNIVAFVMVCVCVCLCVYFVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K933</accession>
    <name>A0A670K933_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Programmed cell death 1 ligand 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PDCD1LG2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K933"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034060.1">
        <property type="protein sequence ID" value="ENSPMRP00000032119.1"/>
        <property type="gene ID" value="ENSPMRG00000020831.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161373"/>
    <dbReference type="OMA" id="ELYIVEH"/>
    <dbReference type="OrthoDB" id="8680608at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046007">
        <property type="term" value="P:negative regulation of activated T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032693">
        <property type="term" value="P:negative regulation of interleukin-10 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032689">
        <property type="term" value="P:negative regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001912">
        <property type="entry name" value="CD274 molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH 1 LIGAND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025487655" evidence="12">
        <location>
            <begin position="24"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="143"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="312" mass="35345" checksum="BD619979D5D4E2D7" modified="2020-06-17" version="1">MSRQMSKLLPIVLLEIQLHMIAALFTVKVLQPRYTAEYGSDVIMGCHFPVHSPLNLMGLSVSWQRKLSLGDKEVYKLNNGQEDLTHQDSDYHGRASLSHEELDKGLSLLSITNIKLTDAGDYICVVKYEGADYKYITLSVEAPYKRINLQERREEEDLILACHSEGYPLAEVSWHYESNLNASIHANTTYEMTRDGLFNITSILRVRPSAPGNYSCAFWNQELNQETSAHKSVVLQDKTSPAHNGGKSPISFILPICLLALFLLIAIAIKVQRSKSSTKLSTRKGKRRKFRQFLKRDLDLQTKDLTEVTVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9H0</accession>
    <name>A0A670K9H0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114583503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K9H0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033362.1">
        <property type="protein sequence ID" value="ENSPMRP00000031447.1"/>
        <property type="gene ID" value="ENSPMRG00000020385.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282532"/>
    <dbReference type="OMA" id="RTISYGX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15912">
        <property type="entry name" value="7tmA_OR6C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000013">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047132">
        <property type="entry name" value="Olfact_rcpt_6C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454:SF18">
        <property type="entry name" value="OLFACTORY RECEPTOR 6C76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="308" mass="34780" checksum="03231E580CEE998D" modified="2020-06-17" version="1">MENQTKINEFLLLGFTENGKLEIFFFVLFLIMYLMAVMGNMMIITITLMDFRLRTPMYFFLRNYAVLEIGYTTAAIPKALFNLASGRKTISYAGCISQLFFYFFLGTTDFFLLTVMSFDRYVAICNPLRYTTIMNEKFCTLLVLFSWIGSLAVILAQTLLYVQFPVCGSNIIDHFFCDSKALLHLLCGDTHFLELSSFILSVFTLLGTLAITVVSYVNIISTVLHIPSAAGRQKAFSTCASHITIVTVTYGSCISMYVIPERDGGQNFNKVVAILNNVVCPLMTPFVYSLRNRQVQDALKNAFGYKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAW3</accession>
    <name>A0A670KAW3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-tubulin N-acetyltransferase 1</fullName>
            <shortName evidence="6">Alpha-TAT</shortName>
            <shortName evidence="6">Alpha-TAT1</shortName>
            <shortName evidence="6">TAT</shortName>
            <ecNumber evidence="6">2.3.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetyltransferase mec-17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ATAT1</name>
        <name evidence="6" type="synonym">MEC17</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>L-lysyl-[alpha-tubulin] + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha-tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15277"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell junction</location>
            <location evidence="6">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetyltransferase ATAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.108" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028569181.1">
        <property type="nucleotide sequence ID" value="XM_028713348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KAW3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035546.1">
        <property type="protein sequence ID" value="ENSPMRP00000033505.1"/>
        <property type="gene ID" value="ENSPMRG00000021725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588270"/>
    <dbReference type="KEGG" id="pmua:114588270"/>
    <dbReference type="CTD" id="79969"/>
    <dbReference type="GeneTree" id="ENSGT00390000008276"/>
    <dbReference type="OMA" id="PPWPFNL"/>
    <dbReference type="OrthoDB" id="447510at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="C:microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004468">
        <property type="term" value="F:L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044546">
        <property type="term" value="P:NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900227">
        <property type="term" value="P:positive regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045598">
        <property type="term" value="P:regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009612">
        <property type="term" value="P:response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048265">
        <property type="term" value="P:response to pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000060">
        <property type="entry name" value="Alpha-tubulin N-acetyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial for catalytic activity" evidence="6">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="459" mass="52590" checksum="6D4505EB4298110D" modified="2020-06-17" version="1">MEFPFDVDALFAERITTVDQHLRPSGRRGAGFATTHRVDHQQQLMRIIDEMGRASAKAQNLPTPITSASRMQTNRHVLYILKDSEAKTAGKGVIIGFLKVGYKKLFVLDRHGAHNEVEPLCVLDFYIHESLQRHGYGKELFHYMLQQERVEPHKLAVDRPSEKLLCFLRKHYNLCDTIPQVNNFVIFQGFFSHHHAPVRKLPQKRHEGEIKPYSSSDREFLKEEVEPPWPFNQSRSLTRSSSLGNSPVRGCLKPFLNEQELLKNLRLCPPHSTAHLLMNGEPGDPASQRRRTRTGTLKDSLMAQKSSYSRFKNSAPAMERSDKRANDLEDNLSSPRKLQESERLDSTIISPPEPANVGQMGETAHPSAEATHQRMDSRTLMTLAPPERIKDHYALAVTNSQPSCENGHHVARLSPQQNRGWHNLPRSPWQMKPLWTVAGSPYEAKWIQHKYLYCNTRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBM7</accession>
    <name>A0A670KBM7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Taste receptor type 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor T2R family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KBM7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034153.1">
        <property type="protein sequence ID" value="ENSPMRP00000032212.1"/>
        <property type="gene ID" value="ENSPMRG00000020877.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286961"/>
    <dbReference type="OMA" id="IFICIAQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033038">
        <property type="term" value="F:bitter taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000055">
        <property type="entry name" value="Taste receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007960">
        <property type="entry name" value="TAS2R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394:SF149">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05296">
        <property type="entry name" value="TAS2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="3 13" id="KW-0919">Taste</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="281" mass="31871" checksum="3E515ADE661C7681" modified="2020-06-17" version="1">GVFFLPPPFSNFILLVIETLIGMVGNGFIAIVNFIDWHRSRKLSPADMILSCLGLFRVLFHEVVIQSAIFNLFFKDAVRPTDVRMASYSSWTFVTTTDLWFATWLSVLYCVKIANFSHPLFLQMKRRFPGLVPWLLLGTVGFSAITTTVAVIGSSKMTKCNLFESFPSNNSDSRIKMSNDCWYVALLYTAPNFLPFMIFLSSSILLLSSLWRHKKLLQSSTRDASTEVHLNAIKALASFFILYISSFLMEILGITWHLKLDIDVLRKAVNGLILYESDGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCD3</accession>
    <name>A0A670KCD3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 121</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KCD3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036082.1">
        <property type="protein sequence ID" value="ENSPMRP00000034020.1"/>
        <property type="gene ID" value="ENSPMRG00000022068.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003866"/>
    <dbReference type="OMA" id="RGGNMIL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042314">
        <property type="entry name" value="TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31046">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31046:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35366" checksum="26F3D348D91D927D" modified="2020-06-17" version="1">LPHVCLSTTLIMSSMVLMDAYLVEQNQGSRKLGICIMVSVGDICFLVVLRYVAVWVGAEVRTAKRGYAMILWFLYVFVLEIKVYFIYQNYKADRKSLDLMARKALTLLLSICIPALYVLLVATEHMEYVRTFKKKEDLRNRLFWVIVDMLDVLDIQANLWEPQKKGLPIWAEGLMFFYCYILLLVLPCVSLCEISMQGISIVPHRMMLYPMLSMLTINIATIFIRGSNMVFFRDIRVSGIFMGKNVLAIALKVCMFAQYRKHLRHAPAGSGGFHRQLSSSSGNMLDHGHLFSFFPQMKTFSIKQKAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEH0</accession>
    <name>A0A670KEH0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KEH0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037393.1">
        <property type="protein sequence ID" value="ENSPMRP00000035266.1"/>
        <property type="gene ID" value="ENSPMRG00000022827.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182928"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="101" mass="11333" checksum="C88E1EF8F944520A" modified="2020-06-17" version="1">MGLSRVSSSTRIQKHPFFAKGPLCPKDANLILPFSQQVDIEQLDPRGRTPLHLATTLGHLECARVLLRHGADVGKENRSGWTVQDWRYVLKPSCFHEQSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEK9</accession>
    <name>A0A670KEK9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MRPS5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028580780.1">
        <property type="nucleotide sequence ID" value="XM_028724947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KEK9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037433.1">
        <property type="protein sequence ID" value="ENSPMRP00000035306.1"/>
        <property type="gene ID" value="ENSPMRG00000022847.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000037438.1">
        <property type="protein sequence ID" value="ENSPMRP00000035311.1"/>
        <property type="gene ID" value="ENSPMRG00000022847.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000037444.1">
        <property type="protein sequence ID" value="ENSPMRP00000035317.1"/>
        <property type="gene ID" value="ENSPMRG00000022847.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000037450.1">
        <property type="protein sequence ID" value="ENSPMRP00000035323.1"/>
        <property type="gene ID" value="ENSPMRG00000022847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594809"/>
    <dbReference type="KEGG" id="pmua:114594809"/>
    <dbReference type="CTD" id="64969"/>
    <dbReference type="GeneTree" id="ENSGT00390000001878"/>
    <dbReference type="OMA" id="LICHRAI"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048584">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21251">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="407" mass="45365" checksum="8C04AEF41289177B" modified="2020-06-17" version="1">MAAAIAVVAQKACSAGALRAAWRGCTLIPGSGVNCHYATLACAFQTHCYISGPRDMTVQPCRRSSFFNKLTADQLWKGVLAESGASGRKGRGKRTKKKLKKDLNRGQIIGEGRSGFLWPGLNAPVLKQGAVQTIDQRDKEEQEKVQAEKLRLREEFDRKRKIKVKRERGWTGRSWGGISLGPPDPSPTGETYEDFDSRVIELKNVFNMTAKEGRRKSVSALVVVGNGNGIAGFALGKATDRMIALRKAKNRAIHYLHYIERYEDHTIYHDIASTVKKTTIRMKKQNKGYGLHCHRAIITMCKLIGVQDMYAKLYGSRNLLNVTRALFRGLAKQETHQNLANKKGLYVVEFCEERGPLPVVVAKPQGAIREDPEPEDEALNVKLEFSEVKAAQGMKKNVWANVRRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KF27</accession>
    <name>A0A670KF27_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neural-cadherin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114600413</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000035423.1">
        <property type="protein sequence ID" value="ENSPMRP00000033392.1"/>
        <property type="gene ID" value="ENSPMRG00000021636.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164400"/>
    <dbReference type="OMA" id="PYHTSQK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000562">
        <property type="entry name" value="Neural-cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000125">
        <property type="entry name" value="Neural-cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000136">
        <property type="entry name" value="Neural-cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000157">
        <property type="entry name" value="Neural-cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000204">
        <property type="entry name" value="Neural-cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000232">
        <property type="entry name" value="Neural-cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000040">
        <property type="entry name" value="neural-cadherin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000119">
        <property type="entry name" value="neural-cadherin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000299">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000035">
        <property type="entry name" value="Protocadherin Fat 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000215">
        <property type="entry name" value="Si:dkey-22o22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000196">
        <property type="entry name" value="Si:dkey-22o22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000224">
        <property type="entry name" value="Si:dkey-22o22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000230">
        <property type="entry name" value="Si:dkey-22o22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000234">
        <property type="entry name" value="Si:dkey-22o22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056370">
        <property type="entry name" value="Shg-like_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF432">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24811">
        <property type="entry name" value="Ig_Shg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025665377" evidence="17">
        <location>
            <begin position="24"/>
            <end position="2847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2664"/>
            <end position="2684"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="356"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="456"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="565"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="659"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="777"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="875"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="975"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1087"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1202"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1304"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1421"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1525"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1642"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1738"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="2102"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="2142"/>
            <end position="2350"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="2388"/>
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        </location>
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            <end position="2646"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033392.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="2847" mass="313211" checksum="C9510127D41D9812" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KF79</accession>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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    </evidence>
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            <dbReference type="Proteomes" id="UP000472272"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <location>
            <begin position="1"/>
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            <dbReference type="PROSITE" id="PS50878"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="990" mass="109075" checksum="F24D5DFB0907C53D" modified="2020-06-17" version="1"> </sequence>
</entry>
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    <accession>A0A670KIK9</accession>
    <name>A0A670KIK9_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CDK16</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
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        <property type="nucleotide sequence ID" value="XM_028712870.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028568704.1">
        <property type="nucleotide sequence ID" value="XM_028712871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KIK9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039067.1">
        <property type="protein sequence ID" value="ENSPMRP00000036891.1"/>
        <property type="gene ID" value="ENSPMRG00000023766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587970"/>
    <dbReference type="CTD" id="5127"/>
    <dbReference type="GeneTree" id="ENSGT00940000156963"/>
    <dbReference type="OMA" id="LIFHMLG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061178">
        <property type="term" value="P:regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07873">
        <property type="entry name" value="STKc_PCTAIRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000061">
        <property type="entry name" value="Putative cyclin-dependent kinase 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF174">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="184"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="515" mass="58499" checksum="B86866518E3CF1E5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLK6</accession>
    <name>A0A670KLK6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neuroligin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NLGN3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KLK6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037734.1">
        <property type="protein sequence ID" value="ENSPMRP00000035597.1"/>
        <property type="gene ID" value="ENSPMRG00000022999.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159580"/>
    <dbReference type="OMA" id="MNCTIPE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030534">
        <property type="term" value="P:adult behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007612">
        <property type="term" value="P:learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071625">
        <property type="term" value="P:vocalization behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000001">
        <property type="entry name" value="Neuroligin 3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000460">
        <property type="entry name" value="Nlgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01090">
        <property type="entry name" value="NEUROLIGIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="15">
        <location>
            <begin position="49"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="856" mass="95349" checksum="D254C0691465DADD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KM97</accession>
    <name>A0A670KM97_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="16">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ACHE</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A670KM97"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038057.1">
        <property type="protein sequence ID" value="ENSPMRP00000035912.1"/>
        <property type="gene ID" value="ENSPMRG00000023193.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157637"/>
    <dbReference type="OMA" id="CDHLVAP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042166">
        <property type="term" value="F:acetylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:laminin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002076">
        <property type="term" value="P:osteoblast development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014788">
        <property type="entry name" value="AChE_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF11">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08674">
        <property type="entry name" value="AChE_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025716728" description="Carboxylic ester hydrolase" evidence="16">
        <location>
            <begin position="28"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="17">
        <location>
            <begin position="30"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Acetylcholinesterase tetramerisation" evidence="18">
        <location>
            <begin position="563"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="15">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="599" mass="68024" checksum="3634138F439E0FB8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KNQ8</accession>
    <name>A0A670KNQ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TIMM22</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KNQ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038822.1">
        <property type="protein sequence ID" value="ENSPMRP00000036652.1"/>
        <property type="gene ID" value="ENSPMRG00000023618.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016067"/>
    <dbReference type="OMA" id="VNPNMAD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="194" mass="20063" checksum="9A517A38FFC261E3" modified="2020-06-17" version="1">MAAASSSTGGPEAAVPPGALQYSLLLEHLVGEKRGPRQARALDPAALGGFPAPAKSPEQKMVERAMESCGFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKTDWKNSVMSGCITGGAIGFRAGLKAGVLGCGGFAAFSAVIDYYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HKP7</accession>
    <name>A0A670HKP7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HKP7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000407.1">
        <property type="protein sequence ID" value="ENSPMRP00000000384.1"/>
        <property type="gene ID" value="ENSPMRG00000000293.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042988">
        <property type="entry name" value="NOBOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47060">
        <property type="entry name" value="HOMEOBOX PROTEIN NOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47060:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN NOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="227"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="269" mass="29275" checksum="CE29C82B6F83DC00" modified="2020-06-17" version="1">MEEFAGQEGKGLREPLLCTDENGNLESEVGARSSVVSVLHTVIMEEKMGQILAKERENDVAKQEQPGDCYIGQGAGSPAPQSSALDSHQLNFVTIYRHLPNYASNINPDPPIPEAELNQEFINQPKPQIPAEVSCLKVSEKGNVKRRSDAVFTAGSLKASSAALEQQSQGMSQNLSHAMRRSARCAAASCVGQQSSKASSFQTAKGKQEGANEKKEPPKAPVEPAPPAQKKTRTFYSAEQLEELERTFHEDHYPDSEKRREIAAAISVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HKW0</accession>
    <name>A0A670HKW0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HKW0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000479.1">
        <property type="protein sequence ID" value="ENSPMRP00000000454.1"/>
        <property type="gene ID" value="ENSPMRG00000000311.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001857">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003288">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001297">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000122">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000466">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000038">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF73">
        <property type="entry name" value="ZINC FINGER PROTEIN 572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="800" mass="89949" checksum="3F274CCC491BFB49" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP37</accession>
    <name>A0A670HP37_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ANKRD1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HP37"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001711.1">
        <property type="protein sequence ID" value="ENSPMRP00000001609.1"/>
        <property type="gene ID" value="ENSPMRG00000001192.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153956"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="PANTHER" id="PTHR24126:SF7">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
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        <property type="entry name" value="Ank"/>
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        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
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    </evidence>
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    </evidence>
    <sequence length="421" mass="48270" checksum="F8A06A281291BF0A" modified="2020-06-17" version="1">MMMLRVEELVTGKKADGRETGDFLPEDFKNGEYEAAVRLEKQEDLKTLTDHSVARHNLTYKEEKALEAEIKKKKLEARPKLESLEDLEKIIQLKKRKKFKKVKVPVVKEPEQEVITEPVDVPTFLKAALENKMPIIEKYLADKGDPNVCDEYKRTALHRACSEGHLAVVEKLVEAGAHLEFQDMLESTAIHWTCRGGNVEILKYLLNKGINRNARDKLLSSPLHVAVRTGQYECGEHLIACEADLNAKDREGDSPMHDAVRLNRYKMIRLLIMYGANLNMKNARTKLLTDKKKKRSLDLISRLSLTFRSLKAANILLSLPPPQQTLCEVSGAERLQRSVTGPRSPRSCMWRSGDANPVPRIMRLPLLTTTPHWLKQKNIRRKKRNVRTAHDIGRPPYHIHRGSLNVERQLFCYVDAHNIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPD0</accession>
    <name>A0A670HPD0_PODMU</name>
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        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HPD0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000950.1">
        <property type="protein sequence ID" value="ENSPMRP00000000897.1"/>
        <property type="gene ID" value="ENSPMRG00000000636.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286918"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000224">
        <property type="entry name" value="Zinc finger protein 329"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 572"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000466">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000785">
        <property type="entry name" value="zinc finger protein 648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002159">
        <property type="entry name" value="Zinc finger protein 841"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF65">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1004" mass="115920" checksum="092E16E3B6F86629" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPT2</accession>
    <name>A0A670HPT2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Veficolin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114600388</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Initiates complement activation and/or interferes in platelet aggregation and/or blood coagulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ficolin lectin family. Veficolin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028592263.1">
        <property type="nucleotide sequence ID" value="XM_028736430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HPT2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001803.1">
        <property type="protein sequence ID" value="ENSPMRP00000001698.1"/>
        <property type="gene ID" value="ENSPMRG00000001247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600388"/>
    <dbReference type="KEGG" id="pmua:114600388"/>
    <dbReference type="GeneTree" id="ENSGT00940000163282"/>
    <dbReference type="OMA" id="SHASEFW"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:antigen binding"/>
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    </dbReference>
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        <property type="term" value="F:carbohydrate derivative binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001867">
        <property type="term" value="P:complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF415">
        <property type="entry name" value="FICOLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1216">Complement system impairing toxin</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="10" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025683454" evidence="12">
        <location>
            <begin position="27"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="13">
        <location>
            <begin position="115"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023220"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="333" mass="35956" checksum="5A643F742C97B2D9" modified="2020-06-17" version="1">MTALTGFRLALTLLVVVSVEERGSFGQEAETSCCEQLKGLSHCGPGGIFFQGQPGIPGLPGVPGTSGSLGPKGDPGPQGPPGEKGVAGMPGKAGPKGDKGDKGEDCSLDTPAGCKPQEAGAKDCKELLERGETLSGWYTIYPATGKAMVVFCDMETDGGGWLVFQRRQDGSEDFYRNWESYKKGFGSHASEFWLGNDKIHLLTSSGLQQLRIDVKDFNDTRTYATYTSFKVLSERDNYTLEVGSYLDGNMGDSFSGHGGMAFSTRDKDNDTNEKGSCAVAYKGGWWYSVCHSSNLNGLYLKGEHSSYANGINWSAGRGHHYSYKYADMKFRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HS04</accession>
    <name>A0A670HS04_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Homeobox C5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HOXC5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028577437.1">
        <property type="nucleotide sequence ID" value="XM_028721604.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028577438.1">
        <property type="nucleotide sequence ID" value="XM_028721605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HS04"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002129.1">
        <property type="protein sequence ID" value="ENSPMRP00000002005.1"/>
        <property type="gene ID" value="ENSPMRG00000001470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593073"/>
    <dbReference type="KEGG" id="pmua:114593073"/>
    <dbReference type="CTD" id="3222"/>
    <dbReference type="GeneTree" id="ENSGT00940000161023"/>
    <dbReference type="OMA" id="AYTMQSY"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000055">
        <property type="entry name" value="Homeobox protein Hox-A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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    <sequence length="247" mass="28165" checksum="1D250AD92A715230" modified="2020-06-17" version="1">MSSYVANSFYKQNQNVPAYSMQSYGNYGSVSEVQPSRYCYSGLDLSITFPSSGASNSLNGVDMSSSPRPNPDRPSCTVMGSAGHTLGRDDQTSLNPGIYSQKACGTTTATTSSSNNSTPLEDRSKSSGEIKSEPVQTAQQSGQSMHQQQQHHQQQQQQQQQPPQIYPWMTKLHMSHEADGKRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKLKSKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HT06</accession>
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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    <name>A0A670HU15_PODMU</name>
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        <submittedName>
            <fullName evidence="15">G protein-coupled receptor 65</fullName>
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                <person name="Marsik P."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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    </dbReference>
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        <property type="entry name" value="Psych_rcpt"/>
    </dbReference>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24234">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID RECEPTOR 5/SPHINGOSYLPHOSPHORYLCHOLINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01649">
        <property type="entry name" value="PSYCHOSINER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="41"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="351" mass="40520" checksum="7B6344F7A8FB606F" modified="2020-06-17" version="1">MERMACNKSLCNETTCLVTYELDQHLFPVLYSILIIISIPANSASLYISYSQIKQKNELGIYLLSLALADLLYTLTLPLWIYYAQNGDNWDLSQQLCTFSVFLKYLNYYTSSAFLTCISIDRYLAVVYPLRFHYLRTRRFALLASIFVWAFEIMSNYQVLKNEDIFNETFLSTNHTFCYDTYPLVNWQAQLNFYRVVVGYAIPLAIMVFCYQKIYGAVKNNQATRNRDKRKINHLLLSIVVTFFLCFTPYHVVLFIRSIVEPCECDCGCGCDAAQRMFIPYRITTALTSLNCIADPILYCFVSETGRMDIWNMLKCGSSESRRDAQLSQKVAISSSSQDKAMMVLKSETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HW59</accession>
    <name>A0A670HW59_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GMPPB</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028574424.1">
        <property type="nucleotide sequence ID" value="XM_028718591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HW59"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003569.1">
        <property type="protein sequence ID" value="ENSPMRP00000003327.1"/>
        <property type="gene ID" value="ENSPMRG00000002355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591493"/>
    <dbReference type="KEGG" id="pmua:114591493"/>
    <dbReference type="CTD" id="29925"/>
    <dbReference type="GeneTree" id="ENSGT00940000158909"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120508">
        <property type="term" value="C:GDP-mannose pyrophosphorylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061728">
        <property type="term" value="P:GDP-mannose biosynthetic process from mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000018">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="9">
        <location>
            <begin position="251"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="360" mass="40146" checksum="93C7E034584D0FBC" modified="2020-06-17" version="1">MKALILVGGYGTRLRPLTLSIPKPLVEFCNKPILLHQVEALVKAGVNHVILAVSYMSELLEKEMKEQEQRLGIHISLSHEKEPLGTAGPLALARELLTENAEPFFVLNSDVICDFPFKDMVQFHRHHGKEGTIVVTKVEEPSKYGVVVCESDTGRIHRFVEKPQVFVSNKINAGMYILNPSVLQRIELRPTSIEKEIFPVMAEQGQLYAMELQGFWMDIGQPKDFLTGMCMYLQYLRLKHPERLHSGPGFMGNVLVDPTAKIGSNCSIGPNVTIGAGVVIEDGVRIKRCTVLKGSRIRSHSWLESCIVGWSSSVGQWVRMENVSVLGEDVIVNDELYLNGANVLPHKSIAESVPEPRIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HX03</accession>
    <name>A0A670HX03_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apolipoprotein F-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC114586548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028565993.1">
        <property type="nucleotide sequence ID" value="XM_028710160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HX03"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004370.1">
        <property type="protein sequence ID" value="ENSPMRP00000004096.1"/>
        <property type="gene ID" value="ENSPMRG00000002798.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586548"/>
    <dbReference type="KEGG" id="pmua:114586548"/>
    <dbReference type="GeneTree" id="ENSGT00500000045104"/>
    <dbReference type="OMA" id="FTHMAPL"/>
    <dbReference type="OrthoDB" id="9895613at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026114">
        <property type="entry name" value="APOF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15011">
        <property type="entry name" value="APOLIPOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15011:SF3">
        <property type="entry name" value="APOLIPOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15148">
        <property type="entry name" value="Apolipo_F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="368" mass="40261" checksum="F34D9C05721093CB" modified="2020-06-17" version="1">MNLSNMYLPSLPPKAFLTFVGFLLLCHESEVHLLSMANPREKASEDHSLTSDSTSVPLRIFLSSISPQSPQLPQKGVSCEDLMPEALDGFADVPELSQTLIRAALVLALQRAGCSQHAETLVLHLYEVLGQVDSDDLLFAMAGTLNTTHSPGPRKSSVALQFNLDQLAQTPVHHCRGLLPVNGSLLYGKAHKVYRGFPAASKACHRLGDSCAGVASSDSSSFYVVERKGSYFLPRHGATSWLHQCRRLGRGRRSTTEYCDNETEEKIYLILDWIPWVGALYSLATSVYFAKLNCMELAHQRAMSCAIDIGHDFLLFATGGASGVLGMGIYAGLKPGLKTAVRAMLRYLREEMHPFPVPSNYSGPVTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXG5</accession>
    <name>A0A670HXG5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ATG101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566242.1">
        <property type="nucleotide sequence ID" value="XM_028710409.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028566252.1">
        <property type="nucleotide sequence ID" value="XM_028710419.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028566261.1">
        <property type="nucleotide sequence ID" value="XM_028710428.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028566269.1">
        <property type="nucleotide sequence ID" value="XM_028710436.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028566277.1">
        <property type="nucleotide sequence ID" value="XM_028710444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HXG5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004678.1">
        <property type="protein sequence ID" value="ENSPMRP00000004383.1"/>
        <property type="gene ID" value="ENSPMRG00000002996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586694"/>
    <dbReference type="KEGG" id="pmua:114586694"/>
    <dbReference type="CTD" id="60673"/>
    <dbReference type="GeneTree" id="ENSGT00390000016511"/>
    <dbReference type="OMA" id="TMNCRSE"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="218" mass="25096" checksum="1F99671EB549B824" modified="2020-06-17" version="1">MNCRSEVLEISVEGRQIEEAMLAVLHTILLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFTYVRVTSDELDRALRKAVGEFKDALRNSGNDGMGQISLEFYQKKKSRWPFSDECIPWEVWTVKVNVVSLANEQERQICREKVGEKLCEKIINIVEVMNRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKIAYQITDSLGTSVTTTMRRLIKDTLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXT9</accession>
    <name>A0A670HXT9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Retinol binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RBP4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HXT9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004280.1">
        <property type="protein sequence ID" value="ENSPMRP00000004010.1"/>
        <property type="gene ID" value="ENSPMRG00000002748.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047107"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140104">
        <property type="term" value="F:molecular carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019841">
        <property type="term" value="F:retinol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034632">
        <property type="term" value="F:retinol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048738">
        <property type="term" value="P:cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048562">
        <property type="term" value="P:embryonic organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060059">
        <property type="term" value="P:embryonic retina morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048807">
        <property type="term" value="P:female genitalia morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060347">
        <property type="term" value="P:heart trabecula formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030277">
        <property type="term" value="P:maintenance of gastrointestinal epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060044">
        <property type="term" value="P:negative regulation of cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007603">
        <property type="term" value="P:phototransduction, visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002639">
        <property type="term" value="P:positive regulation of immunoglobulin production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042572">
        <property type="term" value="P:retinol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060157">
        <property type="term" value="P:urinary bladder development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060068">
        <property type="term" value="P:vagina development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071939">
        <property type="term" value="P:vitamin A import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000004">
        <property type="entry name" value="Retinol-binding protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002449">
        <property type="entry name" value="Retinol-bd/Purpurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11873">
        <property type="entry name" value="RETINOL-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11873:SF2">
        <property type="entry name" value="RETINOL-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500204">
        <property type="entry name" value="RBP_purpurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01174">
        <property type="entry name" value="RETINOLBNDNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0683">Retinol-binding</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="11">
        <location>
            <begin position="82"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="65"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="131"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036893-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036893-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="241" mass="27591" checksum="1DC3E5E097E6DC78" modified="2020-06-17" version="1">MGIESNFSSISRSSLPPNHKSINRKVTGSSPSYRSKMVHLRGVLAWLVLVALALLDTRCQAQRDCRVSSFKVQENFDKYRYAGFWYAVAKKDPEGLFLQDNIVAQFFVDEAGHMTAKAQGRVVLFNQLEICPVMTGIFTETEDPAKFRMKYFGMASYLQKGNDDHWVVATDYDTYALHYSCRQLNEDGTCADSYSFVFSRDANGLRPEAQRIVRQKQTELCLDRQYRVIVHNGYCSEENTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HYI0</accession>
    <name>A0A670HYI0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="27">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">ABL2</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22 27">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts with PSMA7. Interacts with CTTN. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="27"/>
    <dbReference type="AlphaFoldDB" id="A0A670HYI0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004986.1">
        <property type="protein sequence ID" value="ENSPMRP00000004676.1"/>
        <property type="gene ID" value="ENSPMRG00000002982.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153838"/>
    <dbReference type="OMA" id="NIFTQHX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000145">
        <property type="term" value="P:regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05052">
        <property type="entry name" value="PTKc_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09935">
        <property type="entry name" value="SH2_ABL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11850">
        <property type="entry name" value="SH3_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000070">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.330:FF:000003">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000010">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000037">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000004">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035837">
        <property type="entry name" value="ABL_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015015">
        <property type="entry name" value="F-actin-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08919">
        <property type="entry name" value="F_actin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00808">
        <property type="entry name" value="FABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 26 27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="10 26 27" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17 24" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4 25" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7 27" id="KW-0808">Transferase</keyword>
    <keyword evidence="18 27" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SH3" evidence="30">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="29">
        <location>
            <begin position="175"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="31">
        <location>
            <begin position="290"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="600"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="770"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="965"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
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        </location>
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        </source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    <sequence length="1183" mass="128805" checksum="E71EA6E539B2A81E" modified="2020-06-17" version="1"> </sequence>
</entry>
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            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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            <taxon>Bifurcata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2 12">Belongs to the nuclear hormone receptor family. NR3 subfamily.</text>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="131"/>
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    <sequence length="464" mass="51836" checksum="A7A9B35925F597CD" modified="2020-06-17" version="1">MSDEKGIMAEIYTRGIHFGKPGPCRLLCRMSSKDRHIDSSCSSYIKTEPSSPASLTDSINHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPGLGGNGPVRKRYDDCSSTIAEDSQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYAEDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I436</accession>
    <name>A0A670I436_PODMU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
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            <taxon>Lepidosauria</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="477" mass="53309" checksum="AC881B2922ABCCD4" modified="2020-06-17" version="1">MHPSYLNQVLLASDLNHDLNQIHPVSKLPGFYYDPERNRYFRLLPGHNNSNPLTNESIQHRRMESQRLKLLEEEEKCMKKASRSGLNSSIVLRKRQLGLPSSINYRRSIHELKVNCMQRRKLEIETPDSSICGSNNFKLIMADSASERIFTVNDVEHGGCKCGIVNLSGLGKNTLTVEMYDNLYFTNRKVLAVCIVSLISLTTSIKLCLMGIAETLGCASLLPASLFNNSNAGDQPGMLCSFKISTAWSCAWCLNPQANNYFSTGLSQQVHVTNAVTGHRQIFSISSDALAQQFATQAPVLYNGCRSGEIFSIDIRRPMNTGQGLKSLRLFHDSAVTSVNLLKDEQYLLAADMAGRIKLWDLRKLKCVKEYHGHHNEHSILPLHVNEEEGLLTAVGQDCYTRIWSLQDAHLLRTIPSPHPFSTDSIPSVEFSSHLGGSRGVPGLLMAVKQDLHYFSYKTDDPYCLPAKEADNSTPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4J1</accession>
    <name>A0A670I4J1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rho GTPase activating protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSPMRP00000006382.1"/>
        <property type="gene ID" value="ENSPMRG00000004327.1"/>
    </dbReference>
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    <dbReference type="OMA" id="XHNINLV"/>
    <dbReference type="Proteomes" id="UP000472272">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <topology evidence="1">Single-pass membrane protein</topology>
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    <sequence length="495" mass="54368" checksum="6AC03B679F4BAC43" modified="2020-06-17" version="1">RKHSLPGFWRSASETREFYGRSGFASFFKSATAPATPTEKQPLLPASRRPSPPVSMRDTYGTSSLSSSSNSGSCKGSDSSPTPRRPVKYLLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLRARLKDTHERLQDRDAEIDDLKTQLSRMQEEWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLMEKDKGLQKYFVDINIQNKKLETLLHCMEVAQDGTVKEEGAAESAGGSPARSLTRSSTYTKLSDQGAADRNLGGSQISVEEAADSGFVAADDSLSRTDLLDQSSLLSSGVECGTDDTSLQTNFTLGSRVPTSSTYEKLMGSQHSVEAAVQASCMQEQAIQTDFVQYQPDLDTILEKVMKSQACSLASPTSVWNTTEQAASPSPVANSPTVCQPSSASQSVSVMCAPEEEEEEEEPQTYWSRHFIVDLLAVVVPAVPTVAWLCRSQRRQGQPIYNISSLLRGCCTVALHSIRKISCRSVTNTSSSCSQP</sequence>
</entry>
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    <accession>A0A670I6F7</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I6F7"/>
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        <property type="protein sequence ID" value="ENSPMRP00000007325.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="105" mass="12411" checksum="198F62B0147060C8" modified="2020-06-17" version="1">MCKAIFYHSNRWLNPLFVTGHKRKLEEDDMFQVLTEDSSKVLGEGLQWYWDREVQKAKKEARMPHLTKAIILCYWKSYLLLGFFTLIEVILLAFSLGSATFTQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6H1</accession>
    <name>A0A670I6H1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Achaete-scute family bHLH transcription factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ASCL3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I6H1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007775.1">
        <property type="protein sequence ID" value="ENSPMRP00000007264.1"/>
        <property type="gene ID" value="ENSPMRG00000004917.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162850"/>
    <dbReference type="OMA" id="MMDNRSY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007431">
        <property type="term" value="P:salivary gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070654">
        <property type="term" value="P:sensory epithelium regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001894">
        <property type="term" value="P:tissue homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19745">
        <property type="entry name" value="bHLH_TS_ASCL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000038">
        <property type="entry name" value="achaete-scute homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="84"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="168" mass="19276" checksum="389D82B837F9384E" modified="2020-06-17" version="1">MDRLPVLSDSHAGQMSRLGCRDLYAALHFYPEIPNQFAGPEDLPLLPFTPEQLTAENFYSDPCAFPFQGPCGNFGRCEYSCGPAFIRKRNERERQRVKCVNEGYAKLRHHLPAEYLEKRLSKVETLRAAIKYIRYLQSVLYNDSEENSREAHHAPKDSSQSDHAPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I7W0</accession>
    <name>A0A670I7W0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease P/MRP subunit p40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPP40</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028593652.1">
        <property type="nucleotide sequence ID" value="XM_028737819.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593653.1">
        <property type="nucleotide sequence ID" value="XM_028737820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I7W0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008364.1">
        <property type="protein sequence ID" value="ENSPMRP00000007816.1"/>
        <property type="gene ID" value="ENSPMRG00000005289.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600937"/>
    <dbReference type="KEGG" id="pmua:114600937"/>
    <dbReference type="CTD" id="10799"/>
    <dbReference type="GeneTree" id="ENSGT00390000014167"/>
    <dbReference type="OMA" id="HAYNCRV"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="363" mass="41452" checksum="925073FA54FB6797" modified="2020-06-17" version="1">MFAPLRWLREGPRHVLVCEGSHVRHERSRHATRVRDHAFNCQVSFFIPDCGVVPEALKNTVADIGQYYLVKNLSLYELVTQEFINTFVKKGSCYALTYKTRIDQDNTAALLPTGKLIISVDKDTYEELGLQGRPSLYSGKKPMRYIITVDLTDSTFSPDSKKYNRVIWALKEKMPLEFDFLMAWHQTGSEESSLMSYFSKNQIQALQPKITFSTLRNVQCPVLESNKLEGEPETACSAQELFEWLGAIFTHTDLENTSSSFLSTYSCPQPSTTVEQALLCTITGFILPEKIIHLFEQICSYFEEPKLAHWISLIVHGFADSPVSWKESEHGFLKGGENLYNFVIFRSLDYWLQMAVGAYDDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IA47</accession>
    <name>A0A670IA47_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Dimethylaniline monooxygenase [N-oxide-forming]</fullName>
            <ecNumber evidence="20">1.14.13.148</ecNumber>
            <ecNumber evidence="20">1.14.13.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">FMO1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15 20">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20 21">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20 21">Belongs to the FMO family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family. FIG1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.148" evidence="20"/>
    <dbReference type="EC" id="1.14.13.8" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A670IA47"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009162.1">
        <property type="protein sequence ID" value="ENSPMRP00000008571.1"/>
        <property type="gene ID" value="ENSPMRG00000005791.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160945"/>
    <dbReference type="OMA" id="VMIKEVN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047822">
        <property type="term" value="F:hypotaurine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046322">
        <property type="term" value="P:negative regulation of fatty acid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042412">
        <property type="term" value="P:taurine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009404">
        <property type="term" value="P:toxin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002253">
        <property type="entry name" value="Flavin_mOase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01121">
        <property type="entry name" value="FMOXYGENASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20 21" id="KW-0274">FAD</keyword>
    <keyword evidence="5 20 21" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 20 21" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 20" id="KW-0521">NADP</keyword>
    <keyword evidence="11 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="540" mass="60997" checksum="7A730D3B59C2A154" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IB01</accession>
    <name>A0A670IB01_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IB01"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009472.1">
        <property type="protein sequence ID" value="ENSPMRP00000008866.1"/>
        <property type="gene ID" value="ENSPMRG00000005957.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160240"/>
    <dbReference type="OMA" id="QMIERAT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF28">
        <property type="entry name" value="TOM1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="1">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="14800" checksum="9A072055DA3AE61F" modified="2020-06-17" version="1">GGHQVGEDCSSPKSLFATFGALQTEEWGQFMHICDIINTTEEGPKNAIRALRKKLSKNCNHVEIRLTLSLLDMCMQNCGPSFQALVVRRDFCKDRLVKLLNPRFNLPVDMQEKILTFIMVTRVCLHHQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IB55</accession>
    <name>A0A670IB55_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Glutathione S-transferase 3, mitochondrial</fullName>
            <ecNumber evidence="16">4.4.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Glutathione peroxidase MGST3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">LTC4 synthase MGST3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MGST3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:48620"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57450"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:90632"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:48621"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:75963"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:85236"/>
            <dbReference type="ChEBI" id="CHEBI:194498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>leukotriene C4 = leukotriene A4 + glutathione</text>
            <dbReference type="Rhea" id="RHEA:17617"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="EC" id="4.4.1.20"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:17619"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Lipid metabolism; arachidonate metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Lipid metabolism; leukotriene C4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPEG family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.20" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A670IB55"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009743.1">
        <property type="protein sequence ID" value="ENSPMRP00000009125.1"/>
        <property type="gene ID" value="ENSPMRG00000006133.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000009128.1"/>
        <property type="gene ID" value="ENSPMRG00000006133.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000009133.1"/>
        <property type="gene ID" value="ENSPMRG00000006133.1"/>
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        <property type="gene ID" value="ENSPMRG00000006133.1"/>
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    <dbReference type="OrthoDB" id="410651at2759"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:mitochondrial outer membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nuclear envelope"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:glutathione peroxidase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:glutathione transferase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004464">
        <property type="term" value="F:leukotriene-C4 synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0019370">
        <property type="term" value="P:leukotriene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:prostanoid metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Microsomal glutathione S-transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037916"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00039056"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00043664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="143" mass="15764" checksum="313D657FA7F13E72" modified="2020-06-17" version="1">MVVLSKEYGYVILTGAASFILVTHLAINVGKARKKYNVQYPNMYSTDPENGHLFNCIQRAHQNTLEVYSSFLFFLGVSGVYFPRVATGLGASWIIGRLLYAYGYYTGDPKKRNRGVLGSLALLGLAGTTVYSALVHLGWVCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICM2</accession>
    <name>A0A670ICM2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670ICM2"/>
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        <property type="gene ID" value="ENSPMRG00000006482.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="492"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1253" mass="149969" checksum="97FCCD50A4C614A7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDK0</accession>
    <name>A0A670IDK0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore complex protein Nup98-Nup96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">NUP98</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028581274.1">
        <property type="nucleotide sequence ID" value="XM_028725441.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000010651.1">
        <property type="protein sequence ID" value="ENSPMRP00000009995.1"/>
        <property type="gene ID" value="ENSPMRG00000006688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595139"/>
    <dbReference type="KEGG" id="pmua:114595139"/>
    <dbReference type="CTD" id="4928"/>
    <dbReference type="GeneTree" id="ENSGT00550000074799"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042405">
        <property type="term" value="C:nuclear inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.690:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21240">
        <property type="entry name" value="Nup98_GLEBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="19" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="18" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Peptidase S59" evidence="24">
        <location>
            <begin position="726"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="874"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00059309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1721" mass="186460" checksum="F034E953F0AE4712" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFL2</accession>
    <name>A0A670IFL2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IFL2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010885.1">
        <property type="protein sequence ID" value="ENSPMRP00000010217.1"/>
        <property type="gene ID" value="ENSPMRG00000006813.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286962"/>
    <dbReference type="OMA" id="NAYTHEN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="462" mass="51510" checksum="AE45A94AF290BC25" modified="2020-06-17" version="1">MQSSSQVICITMPILGQIVHKNAYTHENNICSGSIPVWLPRWSWTETALVALTDDLRRQLDRGGSGLLILLDLSAAFDMVDHELLDHRLADVGIQGTVLQWLRSFLSGRGQRVALGGELSSRHSLVCGVPQGAILSPMLFNIFMRPLAQLVRSFGLGCHQYADDTQLYLLMDGHPDSAPDTLTRCLEAVAGWLRGSRLKLNPAKTEVLWLGRDDMGSRGQLPSLAGVQLVPAPSVKSLGVIFDTSLSMEAQITAITKAAFFHLRQAKQLAPYLSRPDLATVIHATVTSRLDYCNSLYVGLPLRLTQKLQRVQNAAARLLTGSSLRDHIHPVLYHLHWLPVEYRIRFKVLVLTFKALYGLGPSYLRDRLSWYAPQRNLRSVNKNILKVPGLREVRLASTRARAFSAAAPIWWNALSQETRALRDLTSFRRACKTELFHQAFWSGRSLTPSSGNLHSILVAINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFP3</accession>
    <name>A0A670IFP3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Potassium channel subfamily K member 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IFP3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011250.1">
        <property type="protein sequence ID" value="ENSPMRP00000010546.1"/>
        <property type="gene ID" value="ENSPMRG00000007010.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159791"/>
    <dbReference type="OMA" id="LQSDCSC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005407">
        <property type="entry name" value="KCNK9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF75">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01585">
        <property type="entry name" value="TASK3CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="16">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="16">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="278" mass="31550" checksum="693B3E3133F0A930" modified="2020-06-17" version="1">YGHAAPGTNAGKAFCMCYAALGIPLTLVMFQSLGERMNTFVKYLLQRMKRCCRMRSTDVSMENMVAVGFFSCIGTLCIGAAAFSHCEEWSFFQAFYYCFITLTTIGFGDYVALQTKGALQRKPLYVAFSFMYILVGLTVIGAFLNLVVLRLFMNIEEERREAEERASQAGNRNSMIIHIQEDSQHGRPRYKAEVTDLQSDCSCMCYRSHEYTSRVVSHQNSFSSKLNLQYFHSISYKIEEISPSTLKNSLFPSPVSSISPGLNSFTDSHRLMRRRKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFR9</accession>
    <name>A0A670IFR9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Arachidonate--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.15</ecNumber>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SLC27A1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)</text>
            <dbReference type="Rhea" id="RHEA:33655"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)</text>
            <dbReference type="Rhea" id="RHEA:45264"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a fatty acid(in) = a fatty acid(out)</text>
            <dbReference type="Rhea" id="RHEA:38879"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hexadecanoate(out) = hexadecanoate(in)</text>
            <dbReference type="Rhea" id="RHEA:45256"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.15" evidence="13"/>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A670IFR9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011297.1">
        <property type="protein sequence ID" value="ENSPMRP00000010588.1"/>
        <property type="gene ID" value="ENSPMRG00000007041.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159323"/>
    <dbReference type="OMA" id="IYRDVFK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090434">
        <property type="term" value="F:oleoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044381">
        <property type="term" value="P:glucose import in response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990379">
        <property type="term" value="P:lipid transport across blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015911">
        <property type="term" value="P:long-chain fatty acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001579">
        <property type="term" value="P:medium-chain fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031652">
        <property type="term" value="P:positive regulation of heat generation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010867">
        <property type="term" value="P:positive regulation of triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05939">
        <property type="entry name" value="hsFATP4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000008">
        <property type="entry name" value="Long-chain fatty acid transport protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006134">
        <property type="entry name" value="PRK08279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF7">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="23">
        <location>
            <begin position="82"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="646" mass="72706" checksum="5DB2D7A16BB6F3EC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGH7</accession>
    <name>A0A670IGH7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KIF18A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028585355.1">
        <property type="nucleotide sequence ID" value="XM_028729522.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028585360.1">
        <property type="nucleotide sequence ID" value="XM_028729527.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028585367.1">
        <property type="nucleotide sequence ID" value="XM_028729534.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028585376.1">
        <property type="nucleotide sequence ID" value="XM_028729543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IGH7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011923.1">
        <property type="protein sequence ID" value="ENSPMRP00000011160.1"/>
        <property type="gene ID" value="ENSPMRG00000007454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597212"/>
    <dbReference type="KEGG" id="pmua:114597212"/>
    <dbReference type="CTD" id="81930"/>
    <dbReference type="GeneTree" id="ENSGT00940000159058"/>
    <dbReference type="OMA" id="QPMMSAV"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070463">
        <property type="term" value="F:tubulin-dependent ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072520">
        <property type="term" value="P:seminiferous tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000027">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF73">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="12"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="114"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="915" mass="104855" checksum="56C25D7E255EA925" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHI7</accession>
    <name>A0A670IHI7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Erythroferrone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ERFE</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adipolin/erythroferrone family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IHI7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012357.1">
        <property type="protein sequence ID" value="ENSPMRP00000011570.1"/>
        <property type="gene ID" value="ENSPMRG00000007749.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162100"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140313">
        <property type="term" value="F:molecular sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015908">
        <property type="term" value="P:fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045671">
        <property type="term" value="P:negative regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046326">
        <property type="term" value="P:positive regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000193">
        <property type="term" value="P:positive regulation of fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046628">
        <property type="term" value="P:positive regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019217">
        <property type="term" value="P:regulation of fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052136">
        <property type="entry name" value="Adipolin/Erythroferrone-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019">
        <property type="entry name" value="ADIPOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019:SF11">
        <property type="entry name" value="ERYTHROFERRONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="8">
        <location>
            <begin position="108"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="249" mass="28228" checksum="BAD5955016BCDB17" modified="2020-06-17" version="1">MLPQLFQGSLGAVPWPTGHAACKLQSNIKIAPSPPGFSTLAIQIGFSHNIIMLRLTTKQKSMQGSVIRERERISQKACDNCQEDDDDRSREDNFLAQISGPLLESREHGRVQAAFHCRTRRNISIERRSLQELQFYYIPKKEEMFHRGLGLNLNNGQYIAPFSGYYIFTATLHIEVQLKKNQPRTRERLRLLICGRHQFWHRNLSCFAYPPLSSLFQAGQYASVFVDNATGSTLTVRSGSDFGAVLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670II00</accession>
    <name>A0A670II00_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bcl-2 homologous antagonist/killer</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Apoptosis regulator BAK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BAK1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028589866.1">
        <property type="nucleotide sequence ID" value="XM_028734033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670II00"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011708.1">
        <property type="protein sequence ID" value="ENSPMRP00000010962.1"/>
        <property type="gene ID" value="ENSPMRG00000007303.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599223"/>
    <dbReference type="KEGG" id="pmua:114599223"/>
    <dbReference type="CTD" id="578"/>
    <dbReference type="GeneTree" id="ENSGT01130000278292"/>
    <dbReference type="OMA" id="HYIARWI"/>
    <dbReference type="OrthoDB" id="6020735at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097145">
        <property type="term" value="C:BAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902262">
        <property type="term" value="P:apoptotic process involved in blood vessel morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001783">
        <property type="term" value="P:B cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001782">
        <property type="term" value="P:B cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002352">
        <property type="term" value="P:B cell negative selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001974">
        <property type="term" value="P:blood vessel remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060402">
        <property type="term" value="P:calcium ion transport into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010248">
        <property type="term" value="P:establishment or maintenance of transmembrane electrochemical gradient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044346">
        <property type="term" value="P:fibroblast apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035108">
        <property type="term" value="P:limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002262">
        <property type="term" value="P:myeloid cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032471">
        <property type="term" value="P:negative regulation of endoplasmic reticulum calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090201">
        <property type="term" value="P:negative regulation of release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of calcium ion transport into cytosol"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of protein-containing complex assembly"/>
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        <property type="term" value="P:positive regulation of proteolysis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:post-embryonic camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:release of cytochrome c from mitochondria"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to fungus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:response to gamma radiation"/>
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        <property type="term" value="P:response to mycotoxin"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:thymocyte apoptotic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:vagina development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="bcl-2 homologous antagonist/killer"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Blc2-like"/>
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        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020717">
        <property type="entry name" value="Bcl2_BH1_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020726">
        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF41">
        <property type="entry name" value="BCL-2 HOMOLOGOUS ANTAGONIST_KILLER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01258">
        <property type="entry name" value="BH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="16">
        <location>
            <begin position="82"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="216" mass="25038" checksum="063D5CCEA03593A3" modified="2020-06-17" version="1">MASRRNSSDPANRRRTERRRSSLEVASEDQVAQQTEEVFQSYVFYRYQQEQEQTGQEMPIDPEIAVMQPEHDNINNQVGRRLATIGDDINARYDSEFSEMLKSLKPSRDNAYEYFVKIASSLFESGINWGRVIALLGFGYRMAIHVYQQGLTGFLSRIARYMADFVLRNRIAQWIAQQGGWAAALDLSNVYWKYVVTVAAVILLGHFVMRRFFNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJJ0</accession>
    <name>A0A670IJJ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Max dimerization protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Max-associated protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MXD3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IJJ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013040.1">
        <property type="protein sequence ID" value="ENSPMRP00000012213.1"/>
        <property type="gene ID" value="ENSPMRG00000008170.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161050"/>
    <dbReference type="OMA" id="HTDADHC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF6">
        <property type="entry name" value="MAX DIMERIZATION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="196" mass="22541" checksum="23D6F2D50F02FE8F" modified="2020-06-17" version="1">MELMASNIQVLLQAAEYLERREREAEHGYASLSPYSGKDSLQHELPCHLNASNPHCDLLFSGRRAQLRHCLDQLKQQVPMNTECSRYTTLSLLHRARLHIKKLEEQEQRAQQVKERLRCEQQNLHQRLEELLAHSSVERLRTDSLDSSRFSSERSDSEDAEVDVEGLAFSSVEEDVVAAFSTGQEHSYSSASNFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKG2</accession>
    <name>A0A670IKG2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein Jade-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Jade family PHD finger protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">PHD finger protein 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">JADE1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the JADE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IKG2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012961.1">
        <property type="protein sequence ID" value="ENSPMRP00000012141.1"/>
        <property type="gene ID" value="ENSPMRG00000008116.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158247"/>
    <dbReference type="OMA" id="SSTCWSQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043997">
        <property type="term" value="F:histone H4K12 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043995">
        <property type="term" value="F:histone H4K5 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043996">
        <property type="term" value="F:histone H4K8 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000278">
        <property type="term" value="P:regulation of DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15671">
        <property type="entry name" value="ePHD_JADE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15679">
        <property type="entry name" value="PHD_JADE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000004">
        <property type="entry name" value="Jade family PHD finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000030">
        <property type="entry name" value="Protein Jade-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039546">
        <property type="entry name" value="Jade-1_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF79">
        <property type="entry name" value="PROTEIN JADE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="23">
        <location>
            <begin position="279"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="24">
        <location>
            <begin position="331"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="730"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="809"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="858"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="919" mass="104521" checksum="4BFBB7892CFC25C7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IP96</accession>
    <name>A0A670IP96_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IP96"/>
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        <property type="protein sequence ID" value="ENSPMRP00000013820.1"/>
        <property type="gene ID" value="ENSPMRG00000009265.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162064"/>
    <dbReference type="OMA" id="HINHAFV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008392">
        <property type="term" value="F:arachidonate epoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019373">
        <property type="term" value="P:epoxygenase P450 pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF424">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025691484" evidence="13">
        <location>
            <begin position="25"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="394" mass="45379" checksum="EBEF545ADB75A49B" modified="2020-06-17" version="1">MLELAESLLALLVVCLSALVLLSAWSQMAQRRQLPPGPTPLPILGNLLDLKTHDMLTSFKKVNQYGPVFTVHLGPRRVVVLYGYKAIKEALVTMPKSSVVEGIAFANGERWKQLRRFTLSTLRNFGMGKRSIEERIQEESQFLLEEFRKTDGSPFDPTFFLSRSVSNVICSIVFGRRFDYEDKDFLSLLAKINENFVLMSNTWGQLYEMFPWIMRFLPGPHKKMFRNLDDIYDFVAERVKVNEASLDPDNPRDFIDCFLIQMKKESKNPLSEFHLKTMIMTVLNLFVAGTETVSSTLRFGFLILMKYPEVQEKVIREIDNVIGRDRVPAVEKRAQMPYTDAVIHEIQRFSDVIPTNLPHALTRTVQLRGYTLPKVSHVGLFDYVLFDITSHRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IU32</accession>
    <name>A0A670IU32_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Testis expressed 33</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IU32"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015684.1">
        <property type="protein sequence ID" value="ENSPMRP00000014682.1"/>
        <property type="gene ID" value="ENSPMRG00000009806.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013198"/>
    <dbReference type="OMA" id="MWQACGA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029234">
        <property type="entry name" value="CIMIP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31702">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31702:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15400">
        <property type="entry name" value="TEX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50351" checksum="CDCB37B66B1BA820" modified="2020-06-17" version="1">MASPLLHYIHEPEEVSPVLRYLQHPEEFAALHHQLPQLEEKVDPSVHQSKEVSPVLQYLQQLEEIGTNLLQRDSSLMSSCPRNASKMEDVTQVPMDTTAFPIPAAAYHETRMAGGPTEVPGYGNKEQATYNLTGEQSNNKRPPSRCSSRTSSMNSKNPENRTAMGEPPVLPEASPSTQHIQTRNHNKQTLRSKTPSALCIHTAAGRKDSLEGTTSKGIGNHHHPKGKPGGSRLSAKSSQEEMEDGHGNSDELTGRQYRPIVTRLHASPRKNIKGSCEDMKEAQDVMCAKESLASSGQDVKAEGKALQEKKNSLIIPPNIKAKFGTSMVEKLVSEEQARRALCEAGLIQGQKRLSDWPYKTLENPMASSPYADYYELGYNLRSNIFQGGPLESRSLMKDSYTPDVIKRAVRDPKHWHGRKTDDLGRWFQKNALNLNLQKALEQKYGDKNKGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUD5</accession>
    <name>A0A670IUD5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IUD5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016156.1">
        <property type="protein sequence ID" value="ENSPMRP00000015124.1"/>
        <property type="gene ID" value="ENSPMRG00000010090.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="DKDAWHA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="376" mass="43761" checksum="20539332B08706BB" modified="2020-06-17" version="1">MRWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTTDWFKIGKGVRQGCILSPCLFNLYAEFIMRKAGLDESQAGIKIAGRNINNLRYADDTTLMAESEEELKNLLMRVKEESAKYGLKLNIKKTKIMATGPITSWQIEGEEMEAVRDFIFLGSMITADGDSSHEIKRRLLLGRKAMANLDNILKSRDITLPTKVRIVKAMVFPVVMYGSESWTIKKADRRRIDAFELWCWRRLLRVPWTARRSNASILKEIRPECSLEGQIMKLRLQYFGHLMRREDSLEKTLMLGKMEGTRRRGRQRMRWLDSVLEATNMSLTKLREAVEDRSAWRALVHGVTKSRTRLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWW1</accession>
    <name>A0A670IWW1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Low-density lipoprotein receptor-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LRP11</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDLR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the venom Kunitz-type family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IWW1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016721.1">
        <property type="protein sequence ID" value="ENSPMRP00000015657.1"/>
        <property type="gene ID" value="ENSPMRG00000010457.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161275"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033555">
        <property type="term" value="P:multicellular organismal response to stress"/>
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        <property type="term" value="P:response to cold"/>
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        <property type="term" value="P:response to heat"/>
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        <property type="term" value="P:response to immobilization stress"/>
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        <property type="term" value="P:response to mechanical stimulus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:response to starvation"/>
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        <property type="term" value="P:response to water deprivation"/>
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        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Collagen, type VI, alpha 3"/>
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        <property type="entry name" value="Dyslexia-associated protein KIAA0319 homolog"/>
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        <property type="entry name" value="Serine peptidase inhibitor, Kunitz type 1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="LDL_receptor-like_sf"/>
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        <property type="entry name" value="LDLR_class-A_CS"/>
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        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
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        <property type="entry name" value="MANSC_dom"/>
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        <property type="entry name" value="MANSC_N"/>
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        <property type="entry name" value="PKD_dom_sf"/>
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        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
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        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
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        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
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        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPTI-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="16">
        <location>
            <begin position="504"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="174"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008415"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="609" mass="65494" checksum="D45FDC532CEAC48A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IY16</accession>
    <name>A0A670IY16_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">STAM binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STAMBP</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IY16"/>
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        <property type="protein sequence ID" value="ENSPMRP00000016701.1"/>
        <property type="gene ID" value="ENSPMRG00000011096.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153710"/>
    <dbReference type="OMA" id="MKFMTLF"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110088">
        <property type="term" value="P:hippocampal neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110091">
        <property type="term" value="P:negative regulation of hippocampal neuron apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000010">
        <property type="entry name" value="AMSH-like protease isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000013">
        <property type="entry name" value="STAM-binding protein-like A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF8">
        <property type="entry name" value="STAM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="243"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50249"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="412" mass="47048" checksum="56133381DB786885" modified="2020-06-17" version="1">MPDHADVSLPPEDRVRGLIQMGSSVEVNEDVPPRRYYRSGVEIIRMATIYSEEGNIERAFILYNKYITLFIEKLPKHRDYKTAIIPEKRDTVKKLKEVAFPRAEELKKELLERYNKEYAEYNVQKKKQEEEFARSLALQQQLEEERQRVARMKQQQAEQEQFNAFEEMIRRQELEKERLKIVQQFGKPTPNTSDGPLVPGALKPLSPSGGGVLPKPPTVDRSLKPGALGTPENNTTMEGLRHVTVPRELCHKFLQLADANTARGVETCGILCGKLMKNEFTVTHVIIPKQHGGPDYCNTENEEELFLIQDQYSLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKYQETGFFKLTDHGMEEISSCRQKGFHPHSKDPPLFTLCHAGHVTRKCLRTALAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZT3</accession>
    <name>A0A670IZT3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
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        <property type="gene ID" value="ENSPMRG00000011409.1"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
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    </dbReference>
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    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 9" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
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        <location>
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        <location>
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        <location>
            <begin position="457"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
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        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
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        <ligand>
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        </ligand>
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        <location>
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        <source>
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    </evidence>
    <sequence length="608" mass="68655" checksum="51162DE060960C53" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1D4</accession>
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            <fullName evidence="2">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
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    </gene>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
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            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
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                <person name="Uller T."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
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        </reaction>
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    </dbReference>
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        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
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        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
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        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
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        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF12">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="359"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="498"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="680" mass="76897" checksum="78183C944A9A8029" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2P7</accession>
    <name>A0A670J2P7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hippocalcin-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HPCAL1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028578359.1">
        <property type="nucleotide sequence ID" value="XM_028722526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J2P7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018958.1">
        <property type="protein sequence ID" value="ENSPMRP00000017809.1"/>
        <property type="gene ID" value="ENSPMRG00000011758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593790"/>
    <dbReference type="KEGG" id="pmua:114593790"/>
    <dbReference type="CTD" id="3241"/>
    <dbReference type="GeneTree" id="ENSGT00940000154645"/>
    <dbReference type="OMA" id="RQHTEFN"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000078">
        <property type="entry name" value="Hippocalcin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000072">
        <property type="entry name" value="Hippocalcin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF79">
        <property type="entry name" value="HIPPOCALCIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="193" mass="22283" checksum="1EDDEFE5CDDB5B02" modified="2020-06-17" version="1">MGKQNSKLRPEVLQDLRENTEFTDHELQEWYKGFLKDCPTGHLTVEEFKKIYANFFPYGDASKFAEHVFRTFDTNGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIKGAKSDPSIVRLLQCDPSSASQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3D4</accession>
    <name>A0A670J3D4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114602778</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028597228.1">
        <property type="nucleotide sequence ID" value="XM_028741395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J3D4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019185.1">
        <property type="protein sequence ID" value="ENSPMRP00000018034.1"/>
        <property type="gene ID" value="ENSPMRG00000011879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602778"/>
    <dbReference type="GeneTree" id="ENSGT00940000164106"/>
    <dbReference type="OMA" id="EVCCIHP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000012">
        <property type="entry name" value="Chloride channel K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000028">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002250">
        <property type="entry name" value="Cl_channel-K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF3">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-KB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01119">
        <property type="entry name" value="CLCHANNELKDY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 16" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="While G.M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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            <location evidence="1">Secreted</location>
        </subcellularLocation>
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</entry>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5H0</accession>
    <name>A0A670J5H0_PODMU</name>
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        <submittedName>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Marsik P."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="683" mass="73754" checksum="C7384598512F4A25" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J7T3</accession>
    <name>A0A670J7T3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family with sequence similarity 178 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM178B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM178 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J7T3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020944.1">
        <property type="protein sequence ID" value="ENSPMRP00000019714.1"/>
        <property type="gene ID" value="ENSPMRG00000012871.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064017"/>
    <dbReference type="OMA" id="WEISTHQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044276">
        <property type="entry name" value="CANIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026161">
        <property type="entry name" value="FAM178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16046:SF11">
        <property type="entry name" value="PROTEIN FAM178B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16046">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14816">
        <property type="entry name" value="CANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil SMC6 And NSE5 INteracting (CANIN)" evidence="3">
        <location>
            <begin position="498"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="957" mass="106096" checksum="5C9BD1839F682B89" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBH1</accession>
    <name>A0A670JBH1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pro-neuregulin-4, membrane-bound isoform</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NRG4</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with ERBB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the neuregulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598894.1">
        <property type="nucleotide sequence ID" value="XM_028743061.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028743062.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028743064.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028743065.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028743066.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028743067.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028743068.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028598902.1">
        <property type="nucleotide sequence ID" value="XM_028743069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JBH1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022949.1">
        <property type="protein sequence ID" value="ENSPMRP00000021626.1"/>
        <property type="gene ID" value="ENSPMRG00000014034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603812"/>
    <dbReference type="KEGG" id="pmua:114603812"/>
    <dbReference type="CTD" id="145957"/>
    <dbReference type="GeneTree" id="ENSGT00390000014815"/>
    <dbReference type="OMA" id="AHHNHGE"/>
    <dbReference type="OrthoDB" id="6162427at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038138">
        <property type="term" value="P:ERBB4-ERBB4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045840">
        <property type="term" value="P:positive regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000356">
        <property type="entry name" value="pro-neuregulin-4, membrane-bound isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740:SF14">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="113" mass="12246" checksum="66BCC6B28D738F1E" modified="2020-06-17" version="1">MRTDHEELCGSSYGSFCLNGGICYTIPAISSPFCRCVENYTGNRCEEILLPSIKSHPRGELFAAVLASVVVLSVLVAGAFFFLCRKGQIPRSSSIEHGNNLIEGNSRDACNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JD22</accession>
    <name>A0A670JD22_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC1 domain family member 10B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TBC1D10B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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                <person name="Wallerman O."/>
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                <person name="Bunikis I."/>
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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                <person name="Soler L."/>
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</entry>
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                <person name="Bellati A."/>
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        <scope>IDENTIFICATION</scope>
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</entry>
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        <scope>IDENTIFICATION</scope>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042508">
        <property type="entry name" value="FBXW5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20995">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20995:SF17">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="625" mass="70329" checksum="CB44AB3A0CF88BE8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEX8</accession>
    <name>A0A670JEX8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JEX8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023529.1">
        <property type="protein sequence ID" value="ENSPMRP00000022149.1"/>
        <property type="gene ID" value="ENSPMRG00000014416.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159054"/>
    <dbReference type="OMA" id="ATIYICV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000064">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF15">
        <property type="entry name" value="AQUAPORIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31183" checksum="21DE4C1580177896" modified="2020-06-17" version="1">MTGRIRNLRDQRFTEDWKKYMNYLKSNCNQQITLVIGQGSVAQVVIGKNSFGDFLSINLGFGFGVMLGIHVAGGISGAHMNAAITFANCVVGNLPWYKLPVYVIGQFVGSFLASATTFSLYYEALMDYTGGTLSVGGPTGTANIFATYPSPYMSTLGGFINEFITTAVLLIGILAINDLKNAGALPGTHALSVGLLVAVIGMSLGMNTGYAINPSRDLPPRIFTAVAGWGLEVFNASNNWWWVPVVAPMLGSLLGIFIYNIFIDFHNRPRLDGSRKPDCEGDESGEQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFT3</accession>
    <name>A0A670JFT3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JFT3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024353.1">
        <property type="protein sequence ID" value="ENSPMRP00000022925.1"/>
        <property type="gene ID" value="ENSPMRG00000014882.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156765"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005522">
        <property type="term" value="F:profilin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF12">
        <property type="entry name" value="VASODILATOR-STIMULATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="171" mass="18641" checksum="32691639B2D9D2FC" modified="2020-06-17" version="1">MFLACTEKGAVKSPACCQQAGSSNSATLKYRLPTPCKEEREGKDLGGSWLGHFIVRIPFCTFWQNPSWLSFFFIPPPLPKVVINSPIVKGLKYNQATPNFHQWRDARQVWGLNFGTKEDASQFAGGMMAALEALDSGEGEMEEAGHLAGGPGKVFHLAGDCCFNGTLKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFZ5</accession>
    <name>A0A670JFZ5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JFZ5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024999.1">
        <property type="protein sequence ID" value="ENSPMRP00000023553.1"/>
        <property type="gene ID" value="ENSPMRG00000015268.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161954"/>
    <dbReference type="OMA" id="CHPPATV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002259">
        <property type="entry name" value="zinc finger protein 271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="299" mass="33415" checksum="C2C6A07927E607B3" modified="2020-06-17" version="1">MNPNPQPGGAEAAPTQKQVPGRPEGSLYPGQNQAGQQSEDPGKGWAKPPLPPPLPKGNPSLPPRVYMGPGPSLCVQCGESLAQTRHSVTQPQRAPHPADKFYPCSDCGKSFGVSSHLTIHRRIHTGEKPYECNECGKRFSQSSTLVLHRRIHTGEKPYKCVDCGKCFSVSSHLTKHQRVHTGEKPYECQACGKRFSQSSTLILHQRIHTGERPYKCDECGKTFSVSSHLTIHQRIHTGEKPYHFGWHPAFYELRWRLVGGWGALLMRKVLQGCHPPATVELGPFMRSQHVPSKKHFRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHH9</accession>
    <name>A0A670JHH9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Neurogenic differentiation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NEUROD2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028559422.1">
        <property type="nucleotide sequence ID" value="XM_028703589.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559423.1">
        <property type="nucleotide sequence ID" value="XM_028703590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JHH9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024510.1">
        <property type="protein sequence ID" value="ENSPMRP00000023074.1"/>
        <property type="gene ID" value="ENSPMRG00000014986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582509"/>
    <dbReference type="KEGG" id="pmua:114582509"/>
    <dbReference type="CTD" id="4761"/>
    <dbReference type="GeneTree" id="ENSGT00940000160871"/>
    <dbReference type="OMA" id="LPYDMHL"/>
    <dbReference type="OrthoDB" id="10039134at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008306">
        <property type="term" value="P:associative learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001662">
        <property type="term" value="P:behavioral fear response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071257">
        <property type="term" value="P:cellular response to electrical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021695">
        <property type="term" value="P:cerebellar cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000297">
        <property type="term" value="P:negative regulation of synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090129">
        <property type="term" value="P:positive regulation of synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031915">
        <property type="term" value="P:positive regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19720">
        <property type="entry name" value="bHLH_TS_NeuroD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022575">
        <property type="entry name" value="NeuroD_DUF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016637">
        <property type="entry name" value="TF_bHLH_NeuroD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF83">
        <property type="entry name" value="NEUROGENIC DIFFERENTIATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12533">
        <property type="entry name" value="Neuro_bHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015618">
        <property type="entry name" value="bHLH_NeuroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="1 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="357" mass="40351" checksum="8DC5CAC0E3CAB293" modified="2020-06-17" version="1">MLTRLFSEPSLIPEVQKFSSWADDCDDDDDEDDEASDKDERKGKSCPLQDEQTDGEAKDDHDLGGEEEEEEEEEEGVEEAEGDRPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGQEAGRYHGPNSTFAMHPYTYQCSRLSGAQCASSTMASSHALRTHAYCATYESLYGNASPDYNSSEYDGPLSPPLCVNGNFSLKQDSSPDHEKNYHYSMHYSALPSSRPSGHNLVFGSSGMRSGVHSENVLPYEMHLHHDRGPMYEELNAFFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLL3</accession>
    <name>A0A670JLL3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L28, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRPL28</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028561116.1">
        <property type="nucleotide sequence ID" value="XM_028705283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JLL3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025332.1">
        <property type="protein sequence ID" value="ENSPMRP00000023872.1"/>
        <property type="gene ID" value="ENSPMRG00000015452.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114583934"/>
    <dbReference type="KEGG" id="pmua:114583934"/>
    <dbReference type="CTD" id="10573"/>
    <dbReference type="GeneTree" id="ENSGT00390000017359"/>
    <dbReference type="OMA" id="KMSNRLK"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="254" mass="29612" checksum="2FA0E31A508A36BC" modified="2020-06-17" version="1">MPLHKIPPRLWDALKLQQGIYARLPAHYLRALQEEAAAPPLAVHWRPRGAQHVRNRRTGERERVQDVPVPVYFPPESQQGLWGGEGLVRGWRYARGDKLAARVKKIWKPQLFYRDLYSEILDKKLTITVTMRTMDQIDAVYGFDYYILKTPKAELCSKLGMDLKRTMLLRLARRDPSLHPDDPAKREAIYDKYKEFVIPEEEAEWVGLSLEEAVEKQRLLEKKDPVPLFKVYAEELVQQLEAQKLSESAEVQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JMM5</accession>
    <name>A0A670JMM5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nephrocystin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NPHP3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000027255.1">
        <property type="protein sequence ID" value="ENSPMRP00000025676.1"/>
        <property type="gene ID" value="ENSPMRG00000016570.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156398"/>
    <dbReference type="OMA" id="FKIHQKA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097543">
        <property type="term" value="C:ciliary inversin compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003283">
        <property type="term" value="P:atrial septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060027">
        <property type="term" value="P:convergent extension involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071908">
        <property type="term" value="P:determination of intestine left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071910">
        <property type="term" value="P:determination of liver left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035469">
        <property type="term" value="P:determination of pancreatic left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071909">
        <property type="term" value="P:determination of stomach left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060993">
        <property type="term" value="P:kidney morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048496">
        <property type="term" value="P:maintenance of animal organ identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000095">
        <property type="term" value="P:regulation of Wnt signaling pathway, planar cell polarity pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072189">
        <property type="term" value="P:ureter development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000150">
        <property type="entry name" value="Nephrocystin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000362">
        <property type="entry name" value="Nephrocystin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000693">
        <property type="entry name" value="Nephrocystin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000301">
        <property type="entry name" value="Nephronophthisis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056886">
        <property type="entry name" value="NPHP3_ab_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056883">
        <property type="entry name" value="NPHP3_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056885">
        <property type="entry name" value="TPR_NPHP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25022">
        <property type="entry name" value="NPHP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24884">
        <property type="entry name" value="NPHP3_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24885">
        <property type="entry name" value="TPR_NPHP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Nephrocystin-3 alpha-beta" evidence="14">
        <location>
            <begin position="282"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="11">
        <location>
            <begin position="515"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3 helical" evidence="12">
        <location>
            <begin position="664"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin-3 TPR-repeats region" evidence="13">
        <location>
            <begin position="835"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="975"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1125"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1167"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1209"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1251"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="96"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1320" mass="149992" checksum="09897DB8A0DDE679" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSF0</accession>
    <name>A0A670JSF0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114586863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028566538.1">
        <property type="nucleotide sequence ID" value="XM_028710705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JSF0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028049.1">
        <property type="protein sequence ID" value="ENSPMRP00000026439.1"/>
        <property type="gene ID" value="ENSPMRG00000017101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586863"/>
    <dbReference type="KEGG" id="pmua:114586863"/>
    <dbReference type="GeneTree" id="ENSGT00940000164158"/>
    <dbReference type="OMA" id="ACFSIWD"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04146">
        <property type="entry name" value="RERG_RasL11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="221" mass="24626" checksum="CFF45E13F64DA5D5" modified="2020-06-17" version="1">MLVKLRMAFQQAGKISEGSLPKLEANILVIGAGKVGKSALTVRFLTRRFIGEYGDIESIYTHKVMMAGQEACFSIWDSVCPQMAKLQGCLNEKQLRWADGFVIVYSISDRTSFHFARQQLQRIKQLKKRGGAEKVPVILVGNKRDLQHLRTVSSEEGRLLALSTDAGFFEISAAETYHGALVVFHELLDLVRDSRSATKKAVGIRGLVRSMSAVLGRRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTZ2</accession>
    <name>A0A670JTZ2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Insulin-like growth factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">IGFBP1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds equally well IGF1 and IGF2. Interacts with integrin ITGA5:ITGB1. Interacts with VHL; this interaction inhibits HIF1A degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028606426.1">
        <property type="nucleotide sequence ID" value="XM_028750593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JTZ2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028996.1">
        <property type="protein sequence ID" value="ENSPMRP00000027335.1"/>
        <property type="gene ID" value="ENSPMRG00000017638.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607428"/>
    <dbReference type="KEGG" id="pmua:114607428"/>
    <dbReference type="CTD" id="3484"/>
    <dbReference type="GeneTree" id="ENSGT00940000157394"/>
    <dbReference type="OMA" id="TRGDPNC"/>
    <dbReference type="OrthoDB" id="9926277at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031994">
        <property type="term" value="F:insulin-like growth factor I binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031995">
        <property type="term" value="F:insulin-like growth factor II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043567">
        <property type="term" value="P:regulation of insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.40.20:FF:000001">
        <property type="entry name" value="Insulin-like growth factor binding protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000002">
        <property type="entry name" value="Insulin-like growth factor-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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        <property type="entry name" value="IGFBP1"/>
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        <property type="entry name" value="IGFBP_1-6_chordata"/>
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        <property type="entry name" value="Insulin_GF-bd_Cys-rich_CS"/>
    </dbReference>
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        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11551">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11551:SF6">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01976">
        <property type="entry name" value="IGFBPFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01977">
        <property type="entry name" value="IGFBPFAMILY1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IGFBP_N_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0340">Growth factor binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="12">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="11">
        <location>
            <begin position="174"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023183"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="260" mass="28500" checksum="615538FFE1AC450C" modified="2020-06-17" version="1">MCSTGLRGELLLLLLCPGLILGAALQPMHCAPCTEEELVLCPPVPASCPETAHPPGCGCCHTCALQLGEPCGVYTARCGRGLRCSVPPEEPRPLHALLHGQGTCLPASDTAEAAESLEAEDMPHEDRDMTADQQDNTQLTFAAGQDKPVPWNSAAAHESMKARRLNELKKLKKQAPCKKELYKALEKLTKDQQRIGGEIYRFYLPNCNRNGFYHSKQCETSLDRSPAKCWCVYPKDGSRIPGSIEVTGNPECEQYFDSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JU11</accession>
    <name>A0A670JU11_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoprotein nmb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GPNMB</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMEL/NMB family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028750983.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000026934.1"/>
        <property type="gene ID" value="ENSPMRG00000017398.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114607619"/>
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    <dbReference type="GeneTree" id="ENSGT00950000183188"/>
    <dbReference type="OMA" id="HGWRKWN"/>
    <dbReference type="OrthoDB" id="9940970at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:heparin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045545">
        <property type="term" value="F:syndecan binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034103">
        <property type="term" value="P:regulation of tissue remodeling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045219">
        <property type="entry name" value="PKAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046846">
        <property type="entry name" value="PKAT_KLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059017">
        <property type="entry name" value="PMEL_NMB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11861">
        <property type="entry name" value="MELANOCYTE PROTEIN PMEL 17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11861:SF11">
        <property type="entry name" value="TRANSMEMBRANE GLYCOPROTEIN NMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20433">
        <property type="entry name" value="PKAT_KLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26141">
        <property type="entry name" value="PMEL_NMB_N"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025542460" evidence="5">
        <location>
            <begin position="25"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="6">
        <location>
            <begin position="283"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="570" mass="63214" checksum="5F67169D40046A28" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUE5</accession>
    <name>A0A670JUE5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pseudouridylate synthase RPUSD4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA pseudouridylate synthase domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RPUSD4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028563240.1">
        <property type="nucleotide sequence ID" value="XM_028707407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JUE5"/>
    <dbReference type="SMR" id="A0A670JUE5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028092.1">
        <property type="protein sequence ID" value="ENSPMRP00000026482.1"/>
        <property type="gene ID" value="ENSPMRG00000017119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585112"/>
    <dbReference type="KEGG" id="pmua:114585112"/>
    <dbReference type="CTD" id="84881"/>
    <dbReference type="GeneTree" id="ENSGT00940000158436"/>
    <dbReference type="OMA" id="AKKYWAI"/>
    <dbReference type="OrthoDB" id="428658at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990400">
        <property type="term" value="F:mitochondrial ribosomal large subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070902">
        <property type="term" value="P:mitochondrial tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000015">
        <property type="entry name" value="Mitochondrial RNA pseudouridine synthase RPUSD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF83">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="11">
        <location>
            <begin position="98"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="365" mass="41138" checksum="AA11E34654E40955" modified="2020-06-17" version="1">MAAQSGAPHRALRLVLKAGRRAFSHSQGAAAPLSAQQLAEKIRAEKQEQKKKQAEVPKDRVSRRVQELAQLTKQLQRVHPNVLAKALKNGILYQNKEIVVINKPYGLPVHGGPKVKMCITDVLPVLAKMLDGMKAEPLHLCHRLDKETTGVMVLARDEDTTHQIQQLFKTRQVEKKYWAICIGEPKPAEGVVDIPIMEKEAEGNQLHYKMTLAPNYRMSSEDGNMFKVRKHRDASMAVTQYRVLSSSSSCSLLELHPVTGVKHQIRVHLAYGLGCPILGDHKYSHWNKLAPQKLPKAALKRLGLEQVKARHLPLHLHACQLTLPAKNGSEEDKIHLVCKPPLFFIRSLQRLKLEFPEIRNSEPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUN2</accession>
    <name>A0A670JUN2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JUN2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028804.1">
        <property type="protein sequence ID" value="ENSPMRP00000027154.1"/>
        <property type="gene ID" value="ENSPMRG00000017519.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000204784"/>
    <dbReference type="OMA" id="HWLRTVE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="356" mass="40164" checksum="48C1162E7D7562C3" modified="2020-06-17" version="1">MEDHCSHPQRHVLKMEGEGTAAVASGSCAMFAILPKVAGSFTCSNCMLIALLEDKVQQLEERVATLQRLRELELFLEATEHTVSTKEETGDTPEKEASSPTQVPDIWRNVTQRSRRPRVRSDCLEIHNRFEVLSPSMEDEEQTPFEDLSLITVHQVYKDEQQSQSSRNVQATLERTAHGRTPTKPKRRRVVVIGDSLLRGTEAVICGPDKMSREVCCLPGAKIQDVTERLQGIIKPTEKYPFLLVHVGTNDTASNSPQKIKRDYEALGRKLKQLNAQIVISSVLPVERCGPGREGKIVEVNSWLRKWCKQEWFGFFDHGLQFLEDGLLASDGLHLTTVGRNVFAKNLRNLIRRALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVZ8</accession>
    <name>A0A670JVZ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine rich repeat containing 75B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JVZ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028594.1">
        <property type="protein sequence ID" value="ENSPMRP00000026952.1"/>
        <property type="gene ID" value="ENSPMRG00000017404.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164235"/>
    <dbReference type="OMA" id="HSKWHRQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39654">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 75A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39654:SF5">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 75B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33629" checksum="88B290B62280C589" modified="2020-06-17" version="1">SGTDFARKPFLEKGAEYLAQEAVIPLPYRSPPLLQHLTPLHNLDLGLEGTFLSEVLYKNAAFLNLVDPISHDLLMSLARDLQCPKKEYDPWKSSDRICRQLIYHLTPHSKWHRQGLPRRRSQASLKNSLQKKLSPGTMDLSGIPLSMRDIHRLAYYLQNKGEDLSTVDLSFTDLTDEMMHLLLPFLWPLPNLTHLSLNGNRLTRATVKDLTDAMKEASKFPSLAWIDLGNNVDISSMPQPLLVGLRKRLGQHTTLPTIYEVLDCEAEHSSGAEASQTEEEEGAAAGSKSHDFPPQSCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXG8</accession>
    <name>A0A670JXG8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JXG8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029122.1">
        <property type="protein sequence ID" value="ENSPMRP00000027457.1"/>
        <property type="gene ID" value="ENSPMRG00000017700.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000192439"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF55">
        <property type="entry name" value="LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Immunoglobulin V-set" evidence="6">
        <location>
            <begin position="49"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="196" mass="22384" checksum="723E48987E6075BB" modified="2020-06-17" version="1">MEQGGGTILLFSSEPSPGKLELQIPTFLDRFFLHFLDYTGSSGEKNTEKMKGIVGQSATFLLNTSEQFKKISWLRTKEKQAIQIFVVAFPQKDPEERCELIDQIRAYRGRLDVSEDCKMLQINNLSQEDSGTYKAQIWIADDKETIREIFSLRVYSKMPHSGPHTHTHTHTHTHTHTMFEGNGSTYRVSTDLQGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYA7</accession>
    <name>A0A670JYA7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan 5-hydroxylase 2</fullName>
            <ecNumber evidence="4">1.14.16.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tryptophan 5-monooxygenase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TPH2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin</text>
            <dbReference type="Rhea" id="RHEA:16709"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58266"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="EC" id="1.14.16.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with DNAJC12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.4" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670JYA7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030105.1">
        <property type="protein sequence ID" value="ENSPMRP00000028379.1"/>
        <property type="gene ID" value="ENSPMRG00000018308.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182885"/>
    <dbReference type="OMA" id="VHFNPYT"/>
    <dbReference type="UniPathway" id="UPA00846">
        <property type="reaction ID" value="UER00799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004510">
        <property type="term" value="F:tryptophan 5-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042427">
        <property type="term" value="P:serotonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04929">
        <property type="entry name" value="ACT_TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03346">
        <property type="entry name" value="eu_TrpOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000001">
        <property type="entry name" value="tryptophan 5-hydroxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005963">
        <property type="entry name" value="Trp_5_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041904">
        <property type="entry name" value="TrpOH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01270">
        <property type="entry name" value="Trp_5_monoox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF16">
        <property type="entry name" value="TRYPTOPHAN 5-HYDROXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0408">Iron</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0724">Serotonin biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="20">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="19">
        <location>
            <begin position="146"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="497" mass="56726" checksum="3BC2CD0947913E49" modified="2020-06-17" version="1">MQPAMMMFSSKYWARRGLSLDSAVPLEHPLHGNVTVSIMGCLNRTSSGKNDDKKDNKGASKNESTSEGGKTAVVFSLKNEVGGLVKALRLFQEKHVSMVHIESRKSKRRSSEVEIFVDCDCSKKEFNELIQLLKYETNIVTLNPPENIWTDEEELDCVPWFPRKIAELDKCSQRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMNYKYGQPIPRVDYTPEEIKTWGVVFRELTKLYPTHACREYLKNFPLLTKHCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGSSDEDVQKLATCYFFTIEFGLCKQDGQLRAYGAGLLSSIGELKHALSDKASVKTFDPKTTCLQECLITTFQEAYFVSESFEEAKDKMRDFAKSINRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALSKMNRYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYK0</accession>
    <name>A0A670JYK0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Signal peptide peptidase like 2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JYK0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029515.1">
        <property type="protein sequence ID" value="ENSPMRP00000027827.1"/>
        <property type="gene ID" value="ENSPMRG00000017962.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158753"/>
    <dbReference type="OMA" id="GHCEEIT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF39">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="57216" checksum="253751313F2657CE" modified="2020-06-17" version="1">MLVNQWMKSHQEGNKNRWLHPALGTQNISYSSMCCPPSFFGEEDNDGGGFSTRIASVREGNCNLFESARLRQINQTQGLLTLGGDAPYLVKNRRSRYSWGHCEEVTISGILLQDVDILYLLFKNLIRDLLRKTGVIYLMSMFIVTIGSYWAGRTERRKQQFIESRFKTEDDDFGEITIDTNAYFICTCTVMATFMLLALYYFYDYLVHAMIGIFCLYASFSLHGCLAPFVSKLPFGKRVIHLPFFHKGLEIRTLLLTVLCIAISALWVIFRNENEWGWVLQDVLGISIGIYILRTVHMPTLKNCSLFLFAHLFYDVLCLFVTPFLTKAGKSITDVTAYGTPDSEEIPFLLKVPILPSTSIFDDSSFTAIGLGDIILPGFLVAYCHRFDAQVNSSGVYFLASTLAYSYGLMVTFVVATFLQTSQSTLRIPGALYTHYYYGCCCFSQRVHPFLDRCCLCRRPVSTFFTKRHQAPRYITTFRGKTLSTRRKTNLQHHIPQGRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZC7</accession>
    <name>A0A670JZC7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JZC7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031003.1">
        <property type="protein sequence ID" value="ENSPMRP00000029230.1"/>
        <property type="gene ID" value="ENSPMRG00000018890.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144338"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028747">
        <property type="entry name" value="CatSper2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46923">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46923:SF1">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="122"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="220" mass="26145" checksum="78C2108DB57F7929" modified="2020-06-17" version="1">MYVYIVRFIVEQLCRRHLKEVPFELHPRADAIRSKLIYTFYLIDYLRGLGSAIPRHNIRDFLDHRKLKKLMLTDHHQLVRFNVVPKRNVMITRETRCRNRIRVRCSRWPPVAIWAYSVLNSQIFKVFMIFLICLNMVVLMILVEIRITMEVIIWVIVLIFLVEIGLNWAVSFQDYFKNSWNVFDCTVTIISFIPELILLVEKKHSKAVNTSSRFAVCCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0A0</accession>
    <name>A0A670K0A0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">INTS10</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the Integrator complex, composed of core subunits INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L, INTS12, INTS13, INTS14 and INTS15. The core complex associates with protein phosphatase 2A subunits PPP2CA and PPP2R1A, to form the Integrator-PP2A (INTAC) complex. INTS10 is part of the tail subcomplex, composed of INTS10, INTS13, INTS14 and INTS15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 10 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028701721.1"/>
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        <property type="term" value="P:snRNA processing"/>
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        <property type="entry name" value="Int_cplx_su10"/>
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        <property type="entry name" value="INTSUBUNIT10"/>
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        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="736" mass="84689" checksum="5891DC74291C6DDE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K1W5</accession>
    <name>A0A670K1W5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K1W5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032611.1">
        <property type="protein sequence ID" value="ENSPMRP00000030751.1"/>
        <property type="gene ID" value="ENSPMRG00000019920.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RT_dom"/>
    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="421" mass="48097" checksum="14115BD107DBC741" modified="2020-06-17" version="1">MLKILQGRLKQYVDRELPEVQAGFRRGRGTRDQIANMRWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTIWIWKGVRQGCILSPCLFNLYAEFIMRKAGLDESLARIKIAGRNINNLRYADDTTLMAESEEELKNLLMRVKEESAKICFEAQHQKNEDHGHWSHHLLANRRGRNGGSERFYFLGLHFFISRGVDLACVMETWVREGATVTLREMAPSGFSVLHQSRTVGRGGGVALLIREDCPFRALPSPSIPGIECVGLVWGSEESLAVWLVYRPPSAPAATLSGLLEAVAGWALEFPNPVFPKLFWATAHLFTEKKSHGTPPLKPRPVTSARSVTPGGTHESESFFPPPCRGTSKLWGWEEAAERGTEGRRQLRRRRLLWWWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K341</accession>
    <name>A0A670K341_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K341"/>
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        <property type="protein sequence ID" value="ENSPMRP00000030069.1"/>
        <property type="gene ID" value="ENSPMRG00000019446.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="492"/>
            <end position="766"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1174" mass="140978" checksum="3B032740243AFE9B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K377</accession>
    <name>A0A670K377_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K377"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033913.1">
        <property type="protein sequence ID" value="ENSPMRP00000031978.1"/>
        <property type="gene ID" value="ENSPMRG00000020720.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="GFTGKAH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000703">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001808">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000990">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001730">
        <property type="entry name" value="zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF241">
        <property type="entry name" value="ZINC FINGER PROTEIN 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="427" mass="49147" checksum="81F71CAAAF90BAED" modified="2020-06-17" version="1">MEENRGILDSLVSGGDELEMKNKGDHNEIHTVEEPYQDSDCGESFSQSSHATSHQRNPLEKKHYQCLECGKSFTRSANLTVHQRIHTGEKPYQCVECGKSFNQRAKLISHQRIHTGEKPYHCLECGKSFTDSSSRTSHQRIHTGEKPYQCVECGKSFTRSANLTCHERIHTGEKPYQCVECGKSFRTSFELTLHQRIHTGEKPFQCVECGKSFIRKHSFTSHQRIHTGEKPYQCMECGKSFNRSAHLTSHQRIHTGEKPFQCLECGKSFNERSKLTSHQRIHTGEKPYHCLECGKSFSHRYNLTSHRRIHTGEKPYHCLDCGKSFRTTSELTSHQRIHTGEKPCQCLECGKSFNQRAHLTSHQRIHTGEKPFQCVECGKSFTWKISFTSHQRIHTGENPYQCLECGKSFTRKENLTSHHKIHTGDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K435</accession>
    <name>A0A670K435_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Terminal nucleotidyltransferase 4B</fullName>
            <ecNumber evidence="6">2.7.7.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Non-canonical poly(A) RNA polymerase PAPD5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">PAP-associated domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Terminal guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Terminal uridylyltransferase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Topoisomerase-related function protein 4-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">TENT4B</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24 36">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028596034.1">
        <property type="nucleotide sequence ID" value="XM_028740201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K435"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031501.1">
        <property type="protein sequence ID" value="ENSPMRP00000029702.1"/>
        <property type="gene ID" value="ENSPMRG00000019207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602231"/>
    <dbReference type="KEGG" id="pmua:114602231"/>
    <dbReference type="CTD" id="64282"/>
    <dbReference type="GeneTree" id="ENSGT00940000158301"/>
    <dbReference type="OMA" id="MYRAPRA"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070568">
        <property type="term" value="F:guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060212">
        <property type="term" value="P:negative regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905870">
        <property type="term" value="P:positive regulation of 3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000015">
        <property type="entry name" value="Terminal nucleotidyltransferase 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF51">
        <property type="entry name" value="TERMINAL NUCLEOTIDYLTRANSFERASE 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="23" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="21" id="KW-0464">Manganese</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="33">
        <location>
            <begin position="260"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="32">
        <location>
            <begin position="448"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="37"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="598"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="676"/>
            <end position="758"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="121"/>
            <end position="195"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
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        <location>
            <begin position="651"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="676"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="31">
        <location>
            <begin position="732"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00076530"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
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        <source>
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    <evidence type="ECO:0000259" key="32">
        <source>
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        <source>
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    <evidence type="ECO:0000313" key="35">
        <source>
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        </source>
    </evidence>
    <sequence length="758" mass="82050" checksum="DB897C25A45BBC54" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4H9</accession>
    <name>A0A670K4H9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="26">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">NTRK3</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="26">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Cys-rich_flank_reg_C"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="Tyr_kinase_AS"/>
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        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
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        <property type="entry name" value="NT-3 GROWTH FACTOR RECEPTOR"/>
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        <property type="entry name" value="ig"/>
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        <property type="entry name" value="LRRCT_2"/>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
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    <dbReference type="PRINTS" id="PR01939">
        <property type="entry name" value="NTKRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01942">
        <property type="entry name" value="NTKRECEPTOR3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 23 25" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9 23 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 26" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 26 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="29">
        <location>
            <begin position="210"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="28">
        <location>
            <begin position="539"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="22">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="545"/>
            <end position="553"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23 25">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with SHC1" evidence="24">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with PLCG1" evidence="24">
        <location>
            <position position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="851" mass="96289" checksum="8054621AA49DDD41" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K532</accession>
    <name>A0A670K532_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114592852</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K532"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034616.1">
        <property type="protein sequence ID" value="ENSPMRP00000032643.1"/>
        <property type="gene ID" value="ENSPMRG00000021156.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161831"/>
    <dbReference type="OMA" id="TNMVCGK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050939">
        <property type="entry name" value="Olfactory_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242:SF264">
        <property type="entry name" value="OLFACTORY RECEPTOR 10X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="314" mass="35232" checksum="F7B3767E9BA3E408" modified="2025-10-08" version="2">MQKENHTQVTEFILLGFSVPPELQIAFFILLLLMYILTLIGNLLIMSVVYSDRSLHVPMYIFLFALSCSETCYSLVIVPKMLVDLLAKVRTISFAGCAAQMFLFLGLGATNCLFLTFMGYDRYLAICHPLRYPLLMNTRVIVWLIAISWIAGFLISLSEAAQILRLPFCGPNAIRHFFCHMRAVVRLACTADNTTEVAISTITMLGLAGSLLFIMLTYILILSTILRIPSTEGRQKAFSTCAAHLIVVSVHYTFASIIYFKSSTADTLEDDTLMSIPYTIITPFLSPIIFTLRNKEIKVAVRKVITKKVLSQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K554</accession>
    <name>A0A670K554_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">60S ribosome subunit biogenesis protein NIP7 pre-PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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</entry>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
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    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        </subcellularLocation>
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        </subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="term" value="P:synaptic vesicle endocytosis"/>
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        <property type="entry name" value="Alpha-synuclein"/>
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        <property type="entry name" value="Helix hairpin bin"/>
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        <property type="entry name" value="Synuclein"/>
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        <property type="entry name" value="Synuclein_alpha"/>
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        <property type="entry name" value="ALPHA-SYNUCLEIN"/>
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    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6G5</accession>
    <name>A0A670K6G5_PODMU</name>
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        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AP1G2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
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            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028702300.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028702301.1"/>
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    <dbReference type="RefSeq" id="XP_028558135.1">
        <property type="nucleotide sequence ID" value="XM_028702302.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000033792.1">
        <property type="protein sequence ID" value="ENSPMRP00000031860.1"/>
        <property type="gene ID" value="ENSPMRG00000020636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581759"/>
    <dbReference type="KEGG" id="pmua:114581759"/>
    <dbReference type="CTD" id="8906"/>
    <dbReference type="GeneTree" id="ENSGT00950000182838"/>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="791" mass="86960" checksum="435AC2F3B192777F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K702</accession>
    <name>A0A670K702_PODMU</name>
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        <recommendedName>
            <fullName evidence="13">Pleckstrin homology domain-containing family H member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PLEKHH2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="11">In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Self-associates. Interacts with TGFB1I1.</text>
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    <comment type="subcellular location">
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            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
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        <subcellularLocation>
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            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLEKHH PROTEIN"/>
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    </dbReference>
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    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="703"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="811"/>
            <end position="919"/>
        </location>
    </feature>
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        <location>
            <begin position="955"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="17">
        <location>
            <begin position="1121"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="612"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054898"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064367"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067093"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1493" mass="168534" checksum="FA1ADD1A07E2F180" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K937</accession>
    <name>A0A670K937_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114588405</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K937"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035321.1">
        <property type="protein sequence ID" value="ENSPMRP00000033296.1"/>
        <property type="gene ID" value="ENSPMRG00000021586.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286913"/>
    <dbReference type="OMA" id="SIHETEM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="7tmA_OR2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
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        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="314" mass="35337" checksum="C37DB3E693CD1100" modified="2020-06-17" version="1">MYREASQEEGNQTYEGEFILLGVADRPRLEMLLFAIILICYVMTLLGNTTIIVVSRLDPHLHTPMYFFLCNLSILDLCYTTSLGPRMLVSFWRKNKSISYGGCVAELYISLALGSTECVLLAFMAYDRYAAVCHPLRYTTIMNHSACFTMAAISWVSGFSNSLVQTVLTFRIPRCGENRIDHFFCEVPAFIKLACGDTSLNEAVLFFASVAILLLPVGLITVSYAYIVAAVLRIRSAEGRQKAFNTCASHFIVVSLFYGSAIFSYLQPRSGHSRDQEKMVSLFYTFVTTMLNPLIYTLRNKEVHKALGRAGWRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAM6</accession>
    <name>A0A670KAM6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WW domain-binding protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KAM6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033769.1">
        <property type="protein sequence ID" value="ENSPMRP00000031837.1"/>
        <property type="gene ID" value="ENSPMRG00000020623.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013956"/>
    <dbReference type="OMA" id="YHYYYNA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000767">
        <property type="entry name" value="WW domain-binding protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="14">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="146"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="305" mass="35772" checksum="9AC284AB0B2E81A0" modified="2020-06-17" version="1">MADYWKSQPKKFCDYCKCWIADNKPSIDFHERGKNHKENVAKKISEIKKKSLEKAKEEEKMSKEFAAMEEAAMKAYQEDLKRIGATTESLGQSSAPKKHEEKKEKRKRERETTETSSDETKEWVRGFSPEGYMYYYNTISGESQWEKPEEFQDNLQELQKTAQWMEGTSEDGRTYYYNTETGVSTWEKPDNFVSPSKESQKENHPEDSREMESKKAKSDAGKAGRKSELQKPKRNLRRKTESDDEVEEKPHRRKKISPYGEWQEVKQESSDIEDVPAVRQETSQAASQRVKPYGEWEEITEDKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAZ7</accession>
    <name>A0A670KAZ7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RABGGTA</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="AlphaFoldDB" id="A0A670KAZ7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034763.1">
        <property type="protein sequence ID" value="ENSPMRP00000032784.1"/>
        <property type="gene ID" value="ENSPMRG00000021217.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075121"/>
    <dbReference type="OMA" id="CAWHHRC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000001">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000138">
        <property type="entry name" value="geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1130">
        <property type="entry name" value="Rab geranylgeranyltransferase alpha-subunit, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036254">
        <property type="entry name" value="RabGGT_asu_insert-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009087">
        <property type="entry name" value="RabGGT_asu_insert-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07711">
        <property type="entry name" value="RabGGT_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49594">
        <property type="entry name" value="Rab geranylgeranyltransferase alpha-subunit, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rab geranylgeranyltransferase alpha subunit insert-domain" evidence="12">
        <location>
            <begin position="241"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="560" mass="64820" checksum="C40912A9C4ECF3EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KB57</accession>
    <name>A0A670KB57_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="16">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">POLR1B</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="16"/>
    <dbReference type="RefSeq" id="XP_028580745.1">
        <property type="nucleotide sequence ID" value="XM_028724912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KB57"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036840.1">
        <property type="protein sequence ID" value="ENSPMRP00000034733.1"/>
        <property type="gene ID" value="ENSPMRG00000022501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594787"/>
    <dbReference type="KEGG" id="pmua:114594787"/>
    <dbReference type="CTD" id="84172"/>
    <dbReference type="GeneTree" id="ENSGT00950000183132"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071667">
        <property type="term" value="F:DNA/RNA hybrid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017126">
        <property type="term" value="P:nucleologenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
        <property type="term" value="P:rRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
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        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
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    <keyword evidence="5 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="40"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="187"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="456"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="22">
        <location>
            <begin position="564"/>
            <end position="622"/>
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    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="671"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1034"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1135" mass="127388" checksum="116E5A4835B537DB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCQ0</accession>
    <name>A0A670KCQ0_PODMU</name>
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        <recommendedName>
            <fullName evidence="10">Pumilio homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PUM3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028712286.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000033359.1"/>
        <property type="gene ID" value="ENSPMRG00000021630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587677"/>
    <dbReference type="KEGG" id="pmua:114587677"/>
    <dbReference type="CTD" id="9933"/>
    <dbReference type="GeneTree" id="ENSGT00390000015757"/>
    <dbReference type="OMA" id="YGPEFSI"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Pumilio RNA-binding family member 3"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
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    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
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    </dbReference>
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        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="13">
        <location>
            <begin position="126"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="11">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="638" mass="72080" checksum="F6FC2FC475BDC743" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEG1</accession>
    <name>A0A670KEG1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Keratin, type II cytoskeletal cochleal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114593010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028577305.1">
        <property type="nucleotide sequence ID" value="XM_028721472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KEG1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037384.1">
        <property type="protein sequence ID" value="ENSPMRP00000035256.1"/>
        <property type="gene ID" value="ENSPMRG00000022819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593010"/>
    <dbReference type="KEGG" id="pmua:114593010"/>
    <dbReference type="GeneTree" id="ENSGT00940000162738"/>
    <dbReference type="OMA" id="VESMYQV"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF21">
        <property type="entry name" value="KERATIN, TYPE II CYTOSKELETAL 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="119"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="116"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="328"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="503" mass="54883" checksum="7C2B93FFC11C4857" modified="2020-06-17" version="1">MSKFGYSSRSAAGSGGFTQVRVSSVSSSRGIGGGGSFSKPGGFGSSSLYNLGSGVRRIAPASSYSVQSSYGALGSSRHGGMYGGGFSPAGIQEVTINQNLLSPLNLEIDPTIQKVRKEEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWNLLQEQKTTRSNIPAFFEAYISNLRRQLDALVNDKGRLEGELKNMQDLVEDFKNKYEDEINKRTTAENDFVVLKKDVDASYMNKVELEARVDGMTDEINFLRALYENELRELQNQISDTSVVLQMDNNRNLDLDSIIAEVKAQYEEIANKSRIEAESWYQSKYEALQASAGKHGDDLRNTKNEIAEINRTILRMQAEIENVKNQRAKLDAAIAEAEERGEMAIKDAKGKLAELEAALNKAKQEMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLAGDGVGSMSMTVLNSSSGGSYGSGGGYGFGGGIGLGSGMGSGGGLSFSSGGGSGALKSSYSVTTSTSRRSVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEG3</accession>
    <name>A0A670KEG3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">P-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KEG3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036060.1">
        <property type="protein sequence ID" value="ENSPMRP00000033999.1"/>
        <property type="gene ID" value="ENSPMRG00000022054.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01070000254068"/>
    <dbReference type="OMA" id="CQCKIAP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.110.10:FF:000006">
        <property type="entry name" value="Trefoil factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017994">
        <property type="entry name" value="P_trefoil_chordata"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017957">
        <property type="entry name" value="P_trefoil_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13826">
        <property type="entry name" value="INTESTINAL TREFOIL FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13826:SF14">
        <property type="entry name" value="TREFOIL FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00680">
        <property type="entry name" value="PTREFOIL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00025">
        <property type="entry name" value="P_TREFOIL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="P-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="14724" checksum="9208A3BF542DBD81" modified="2020-06-17" version="1">HPWEYLPYGSWATNRLKLMAELRFLSVCNCNVPPNRRRECGYSGIPRFTCLRRGCCFNNSIRNTICQVPSCFVNIPSTQQCAVQPKARVNCGYPYISAQTCHSRGCCFDSSIPGVIWCFFPGSDSACRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEU1</accession>
    <name>A0A670KEU1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-crystallin A4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Beta-A4 crystallin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CRYBA4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
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    <comment type="subunit">
        <text evidence="6">Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.</text>
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        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
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        <property type="entry name" value="G_crystallin-like"/>
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        <property type="entry name" value="BETA-CRYSTALLIN A4"/>
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        <property type="match status" value="2"/>
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    <keyword evidence="4" id="KW-0273">Eye lens protein</keyword>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KF73</accession>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="Ensembl"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
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        <location>
            <position position="35"/>
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    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="108"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="233" mass="26477" checksum="20302F1E109E3C8A" modified="2020-06-17" version="1">MVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQSKEALQDVEDENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFC0</accession>
    <name>A0A670KFC0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arrestin beta 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ARRB2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028559800.1">
        <property type="nucleotide sequence ID" value="XM_028703967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KFC0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038273.1">
        <property type="protein sequence ID" value="ENSPMRP00000036118.1"/>
        <property type="gene ID" value="ENSPMRG00000023334.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582724"/>
    <dbReference type="KEGG" id="pmua:114582724"/>
    <dbReference type="CTD" id="409"/>
    <dbReference type="GeneTree" id="ENSGT00950000182887"/>
    <dbReference type="OMA" id="AFCAKIQ"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031701">
        <property type="term" value="F:angiotensin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031748">
        <property type="term" value="F:D1 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043422">
        <property type="term" value="F:protein kinase B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032695">
        <property type="term" value="P:negative regulation of interleukin-12 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032715">
        <property type="term" value="P:negative regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045953">
        <property type="term" value="P:negative regulation of natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034122">
        <property type="term" value="P:negative regulation of toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000727">
        <property type="term" value="P:positive regulation of cardiac muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032226">
        <property type="term" value="P:positive regulation of synaptic transmission, dopaminergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098926">
        <property type="term" value="P:postsynaptic signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000003">
        <property type="entry name" value="beta-arrestin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.840:FF:000001">
        <property type="entry name" value="beta-arrestin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF20">
        <property type="entry name" value="BETA-ARRESTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="194"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="411" mass="46172" checksum="4CBE3CBE6EC206C3" modified="2020-06-17" version="1">MGEKAGTRVFKKSSPNCKLTVYLGKRDFVDHLDRVDPVDGVVLVDPEYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFLASWQAFPPPEETAEPLTRLQERLLRKLGANAHPFSFIIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKIQDEKIHKRNSVRLVIRKVQYAPEKPGPQPMAETTRHFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSSKSVKKVKVSVRQYADICLFSTAQYKCPVAQIEQDDQVAPSSTFCKVYTLTPLLSNNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPPDQASPTLQPQLAAPETDAPVDTNLIEFETNYGQDDDIVFEDFARLRLKGLKDDKEDDDHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFF9</accession>
    <name>A0A670KFF9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KFF9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036454.1">
        <property type="protein sequence ID" value="ENSPMRP00000034359.1"/>
        <property type="gene ID" value="ENSPMRG00000022304.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234669"/>
    <dbReference type="OMA" id="EHESSIC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="152" mass="17423" checksum="4162DC223B76045C" modified="2020-06-17" version="1">MAAAGGHIQRLRDEATCPICRDYFKDPVTIPECGHNFCRSCLAQCWGEAEASCPQCRKRIQRRSLVCNWQLANMVEIAKNLGFQEGKEEGGKGRICEKHQEPLKLFCKVHEAPICLVCDRSKEHENHKVIPLEEASEEYKVGDPWIWRGRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KG99</accession>
    <name>A0A670KG99_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KG99"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038621.1">
        <property type="protein sequence ID" value="ENSPMRP00000036453.1"/>
        <property type="gene ID" value="ENSPMRG00000023520.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00970000193985"/>
    <dbReference type="OMA" id="QFLPCNY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026507">
        <property type="entry name" value="PIRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899">
        <property type="entry name" value="PIERCE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899:SF4">
        <property type="entry name" value="PIERCER OF MICROTUBULE WALL 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14892">
        <property type="entry name" value="PIRC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="115" mass="12480" checksum="EC07CCEBF821FB15" modified="2020-06-17" version="1">SAGGDPDAESTKGNTSSVQWRPCANPGNPVFSCMLEAKTLTSSNFLTKPQLLLYKTSGEYGAIPPTTQMVPCKFCPKDNTFTNHLFTCGMTRFNGINTGTDKNKVCDHSDLMHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGH4</accession>
    <name>A0A670KGH4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase cAMP-dependent type I regulatory subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PRKAR1B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KGH4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036836.1">
        <property type="protein sequence ID" value="ENSPMRP00000034729.1"/>
        <property type="gene ID" value="ENSPMRG00000022498.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157513"/>
    <dbReference type="OMA" id="PHPTIHE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007611">
        <property type="term" value="P:learning or memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141162">
        <property type="term" value="P:negative regulation of cAMP/PKA signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098693">
        <property type="term" value="P:regulation of synaptic vesicle cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12102">
        <property type="entry name" value="DD_RIbeta_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000013">
        <property type="entry name" value="cAMP-dependent protein kinase type I regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000001">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042818">
        <property type="entry name" value="RIbeta_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF126">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0114">cAMP</keyword>
    <keyword evidence="5" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="231"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="349"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="475" mass="53922" checksum="CE43382F760C04B2" modified="2020-06-17" version="1">AKHIQILDLRLPKEREMQSVINTAQSALLFAHPDQSQLQFEHVTEILKVTFCPVFENLISVPFCTPEDFGEWLMLLETPCRFLTQVCCLFTVTKMAASSSCNVEDDESLKGCERYVQKHNIQQILKECIVNLCIAKPDRPMKFLREHFEKLEKEECKQILAWQKSNSQSDSHDDEISPPPPNPVVKARHRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGDEGDNFYVIDQGEVDVYVNGEWVTSIGEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFFIITEGTASVLQRRSDNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGP3</accession>
    <name>A0A670KGP3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KGP3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038323.1">
        <property type="protein sequence ID" value="ENSPMRP00000036161.1"/>
        <property type="gene ID" value="ENSPMRG00000023371.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF240">
        <property type="entry name" value="ZINC FINGER PROTEIN 772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="424" mass="48492" checksum="674DDBA0418081CD" modified="2025-10-08" version="2">MDTELTCTSMDSCESRMIPRPHTWSFRGTVTPFRTRESSIPTRPLSSKNSTVVPRKTKLIRSASSFFLRVFRLAKSEDSGEDALRFPAVPEISLWAVVLRSKPIGKFRVFRLARRSSCGVPLYFCLVRIQPQSVNHHPSSNHVQNPYLFVAGGDELQIKNQQMHDKIHTVENPYQYVECGESSHSLSHPRIPTGKKKHQCLECGKSFRQRAHLTAHQMSHKGEKPYQCLECGKSFSKKAYVTSHQRIHTREKPYQCLHCGKSFNQRSHLTIHERIHTREKPYQCLECGKCFSQRSHLTTHQIIHTGEKPYQCLECGKGFSSKAYVTSHQKIHTREKPYQCLHCGKIHSERKSHFPSKNSYLGESPHKCLECGESFSQESLLTSHQRTHSGENQNPLESLDCCIGLDGESHLLQAPAMDIQQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KH03</accession>
    <name>A0A670KH03_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidoglycan recognition protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PGLYRP2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KH03"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037017.1">
        <property type="protein sequence ID" value="ENSPMRP00000034909.1"/>
        <property type="gene ID" value="ENSPMRG00000022596.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158718"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016019">
        <property type="term" value="F:peptidoglycan immune receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016045">
        <property type="term" value="P:detection of bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF66">
        <property type="entry name" value="N-ACETYLMURAMOYL-L-ALANINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025343617" evidence="3">
        <location>
            <begin position="18"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="5">
        <location>
            <begin position="322"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="4">
        <location>
            <begin position="335"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="501" mass="55285" checksum="2A0A559C8DB2E2E2" modified="2020-06-17" version="1">MLLPWLSLIPVLFCVSADSTDYSTLHMDSVTGVLEDFESQLRGTPDQTVTELFRELECCKGELCQLLLGPVTSAPSDVSYLSEQQSIFLKNLVNHEVDASLVEHGVVLTPDGTTVSLSPLLAGIAVGLQRSHKETLHATPLIANSTNSSVVELPLTLEPLFATTIAMDLGKAFLLFHTNRSQVALGPDGCWDSISAPQKFTLMGAPSTLPDAFINGAMDGLILGTYLAEKADPPSNLSVLLKDYYGGEGLGGESAMQSNFRRKNFAALVSEEKLRMQVEDSLLLLRRLNESNPLFDGLTNEELRSVANQAVEEFTALYVECPAIIPRCMWGARPYRGTPAQLQLPLGFVYIHHTSTPAKPCRSFPSCAADMRSMQRFHQDFRGWDDIGYSYVAGGDGYIYQGRGWHWVGAHTRSYNTKGYGISFIGDYMEALPDAQSMELVKNNFIKCAVRGSKLQANYTIHGHRQMGNTLCPGDRLFKEIQTWKGFAERCFTDKGVRRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KH63</accession>
    <name>A0A670KH63_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde dehydrogenase 1 family member A2</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <end position="191"/>
        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="196" mass="21723" checksum="5D5E360FCE4625B7" modified="2020-06-17" version="1">MTSSKIEMPGGLKADPAALMASLHLLPSPTLNLEIKYTKIFINNEWQNSESGKVFPVSNPATGEQICEVQEAEKPDTDKAVRAARLAFSLGSVWRRLDASERGRLLDKLADLVERDRALLATMESLNSGKPFLQAFYVDLQGVIKTLRYYAGWADKIHGATIPVDGDYFTFTRHEPIGVCGQIIPNWSLPLGKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJI4</accession>
    <name>A0A670KJI4_PODMU</name>
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        <submittedName>
            <fullName evidence="14">ATP binding cassette subfamily G member 4</fullName>
        </submittedName>
    </protein>
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        <name evidence="14" type="primary">ABCG4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028707848.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000037949.1">
        <property type="protein sequence ID" value="ENSPMRP00000035804.1"/>
        <property type="gene ID" value="ENSPMRG00000023134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585319"/>
    <dbReference type="KEGG" id="pmua:114585319"/>
    <dbReference type="CTD" id="64137"/>
    <dbReference type="GeneTree" id="ENSGT00940000157853"/>
    <dbReference type="OMA" id="WIDVCIM"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
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        <property type="component" value="Chromosome 15"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cholesterol efflux"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000267">
        <property type="entry name" value="ATP-binding cassette, sub-family G (WHITE), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF75">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="298"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="642" mass="72038" checksum="A889927A95467112" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KL08</accession>
    <name>A0A670KL08_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SLC4A8</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028577310.1">
        <property type="nucleotide sequence ID" value="XM_028721477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KL08"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037510.1">
        <property type="protein sequence ID" value="ENSPMRP00000035382.1"/>
        <property type="gene ID" value="ENSPMRG00000022888.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593014"/>
    <dbReference type="KEGG" id="pmua:114593014"/>
    <dbReference type="CTD" id="9498"/>
    <dbReference type="GeneTree" id="ENSGT00940000157422"/>
    <dbReference type="OMA" id="SIEEISX"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140892">
        <property type="term" value="F:sodium,bicarbonate:chloride antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000302">
        <property type="term" value="P:positive regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003024">
        <property type="entry name" value="Na/HCO3_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF37">
        <property type="entry name" value="ELECTRONEUTRAL SODIUM BICARBONATE EXCHANGER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01232">
        <property type="entry name" value="NAHCO3TRSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="727"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="815"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="970"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="17">
        <location>
            <begin position="110"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="16">
        <location>
            <begin position="445"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="394"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1088" mass="122199" checksum="061F7D14E54D927E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HKW2</accession>
    <name>A0A670HKW2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Serine/threonine-protein kinase MRCK beta</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">CDC42-binding protein kinase beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">DMPK-like beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Myotonic dystrophy kinase-related CDC42-binding kinase beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="41" type="primary">CDC42BPB</name>
    </gene>
    <organism evidence="41 42">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="41 42" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="41" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="41" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="27">Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26 43">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25 43">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028560260.1">
        <property type="nucleotide sequence ID" value="XM_028704427.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000000116.1">
        <property type="protein sequence ID" value="ENSPMRP00000000110.1"/>
        <property type="gene ID" value="ENSPMRG00000000071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114583046"/>
    <dbReference type="KEGG" id="pmua:114583046"/>
    <dbReference type="CTD" id="9578"/>
    <dbReference type="GeneTree" id="ENSGT01030000234517"/>
    <dbReference type="OMA" id="ELEALKX"/>
    <dbReference type="OrthoDB" id="10047816at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042641">
        <property type="term" value="C:actomyosin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HLQ6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000444.1">
        <property type="protein sequence ID" value="ENSPMRP00000000421.1"/>
        <property type="gene ID" value="ENSPMRG00000000310.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012493"/>
    <dbReference type="OMA" id="ISGCYAR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001711">
        <property type="term" value="P:endodermal cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019827">
        <property type="term" value="P:stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000001">
        <property type="entry name" value="RNA polymerase-associated protein RTF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="11">
        <location>
            <begin position="312"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="669" mass="76375" checksum="CE726EBE10A56965" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HN79</accession>
    <name>A0A670HN79_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">POU1F1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HN79"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001031.1">
        <property type="protein sequence ID" value="ENSPMRP00000000971.1"/>
        <property type="gene ID" value="ENSPMRG00000000674.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158913"/>
    <dbReference type="OMA" id="TSHAHGM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000150">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000007">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF84">
        <property type="entry name" value="NETRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="13">
        <location>
            <begin position="198"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="288"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="366" mass="40928" checksum="3C2BC48529C8EF24" modified="2020-06-17" version="1">MSCQAFPSADTFIPLNSDSSPSLPLIMHHSAAECLPVSNHATNVVSTGTFFILSVLLFSMCRALASFICYASLHYSIPSCHYGNQQAAYGVMAGIKPAGPDMLAASLSQSRILQTCSMPHPNIVNGVGTLQGKSVLFHFVFLTPCLYKFPDHALSASSCALGHSFPSMHPSILGDDSVTDFKQEFRKKNKSIEEPIDMDSPEIRELEKFANEFKLRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKSILTKWLEEAEQVGALYNEKVGVNERKRKRRTTISIAAKEALESHFAEQSKPSSQEIMRMAEGLNLEKEVVRVWFCNRRQREKRVKTSLHQNTFNSMIKDHQECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP23</accession>
    <name>A0A670HP23_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CTDSP2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028577332.1">
        <property type="nucleotide sequence ID" value="XM_028721499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HP23"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000829.1">
        <property type="protein sequence ID" value="ENSPMRP00000000782.1"/>
        <property type="gene ID" value="ENSPMRG00000000573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593025"/>
    <dbReference type="KEGG" id="pmua:114593025"/>
    <dbReference type="CTD" id="10106"/>
    <dbReference type="GeneTree" id="ENSGT01040000240451"/>
    <dbReference type="OMA" id="ESCIFHQ"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000013">
        <property type="entry name" value="Carboxy-terminal domain RNA polymerase II polypeptide A small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040078">
        <property type="entry name" value="RNA_Pol_CTD_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01124">
        <property type="entry name" value="C0.1:_RNA_Pol_CTD_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="8">
        <location>
            <begin position="97"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="271" mass="30670" checksum="3EB5A47ABB93C5DB" modified="2020-06-17" version="1">MESRSIITQVQRDEALVLSKQVLVSKSSPKKPRGRNIFKAFFCCLRAQNVGQSGFGGDHGPHKEETSTIAKSDLLQCLQYQFYQIPGTCLLPEVTLQDQGRICVVIDLDETLVHSSFKPINNADFIVPVEIEGTTHQVYVLKRPFVDEFLRRMGELFECVLFTASLAKYADPVTDLLDKCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSEAEDVYTSLGQLRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPW5</accession>
    <name>A0A670HPW5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MRPL21</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HPW5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001154.1">
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        <property type="gene ID" value="ENSPMRG00000000786.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005535"/>
    <dbReference type="Proteomes" id="UP000472272">
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    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="210" mass="23951" checksum="D9C120E9C872B434" modified="2020-06-17" version="1">MAGPHWGWTQRPTVGGARVNDRQSQLILVLSPSSSLLSFSRAQLRLRRRKLTGSGGGWLLLPKTSLTSPPYPEIKLPDPLEEAEHHREIVQKVNELIAMGQYGRLFAVVHFASRQWKVTSEDLILLNNDIPAECGDRIRMEKVNDFTLLESHCWGKDLVRVEATVIEKTESWPKIRMIIRRKSNYKKKTILIQPQTVLRINSIEIAPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQH3</accession>
    <name>A0A670HQH3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCAN box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HQH3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002072.1">
        <property type="protein sequence ID" value="ENSPMRP00000001948.1"/>
        <property type="gene ID" value="ENSPMRG00000001434.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000005">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="3">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="175" mass="19590" checksum="03941A81C62C9A70" modified="2020-06-17" version="1">VLAKLIQACLENISPFLTRQQFRHFCYHEAKGPREVCNQLHHLCRQWLKPEQHTKTQILDQVILEQFLAVLPLEMQSWVRECGAETSSQAVALAEGFLLSQAEDRKQEQQQVRMFHHDGSQGIQNVREGPPQPSPLQSGREAASVALDKVGVAGQWGKEAGGIQHISVPSSPPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HR33</accession>
    <name>A0A670HR33_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PPP3CB</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A670HR33"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002377.1">
        <property type="protein sequence ID" value="ENSPMRP00000002234.1"/>
        <property type="gene ID" value="ENSPMRG00000001624.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154115"/>
    <dbReference type="OMA" id="PSHGLMC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005955">
        <property type="term" value="C:calcineurin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030346">
        <property type="term" value="F:protein phosphatase 2B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140367">
        <property type="term" value="P:antibacterial innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031987">
        <property type="term" value="P:locomotion involved in locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001946">
        <property type="term" value="P:lymphangiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023057">
        <property type="term" value="P:negative regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001915">
        <property type="term" value="P:negative regulation of T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905673">
        <property type="term" value="P:positive regulation of lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900242">
        <property type="term" value="P:regulation of synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030217">
        <property type="term" value="P:T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043029">
        <property type="term" value="P:T cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001913">
        <property type="term" value="P:T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="13">
        <location>
            <begin position="151"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="518" mass="58339" checksum="0D141ECB78E34F36" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRD1</accession>
    <name>A0A670HRD1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HRD1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001881.1">
        <property type="protein sequence ID" value="ENSPMRP00000001770.1"/>
        <property type="gene ID" value="ENSPMRG00000001304.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234669"/>
    <dbReference type="OMA" id="YPESISC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16594">
        <property type="entry name" value="RING-HC_TRIM7-like_C-IV"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="152"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="360" mass="42090" checksum="1CA81C1C7856D0B3" modified="2020-06-17" version="1">MAAAGGHIQRLRDEATCSICLEYFKDPVTIPECGHNFCRSCLILFWGESEAEASCPQCRERVQRRSLISNWQLANMVEIAQNLSLQEGKEEGGKGGVCEDHQEPLKLFCKVHEAPICLVCDRSKEHENHKVIPLKEAFEEYKGEICRRLKILRKEREEILAYQAALDKESKDLLKLTETERLKAVEKFRELRQFLEEQEKRLLTHVEEVEKEIAGRRDEQLAKFSRKLSSLERIIQEMEEKSQQPASELLQDVRRTLQRYEERESPEKPLAFPPELRNRILESCDLNHLVEDRMNLWEDAVLFRKQLQKDVQSFRHLQRANVTLDLDTAHPELILSEDRKSLKRRNTKDDCPASPKHLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HS78</accession>
    <name>A0A670HS78_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114601585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HS78"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002792.1">
        <property type="protein sequence ID" value="ENSPMRP00000002624.1"/>
        <property type="gene ID" value="ENSPMRG00000001883.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282552"/>
    <dbReference type="OMA" id="XTEFILL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15230">
        <property type="entry name" value="7tmA_OR5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="319" mass="35733" checksum="63A3CDCDBF452704" modified="2020-06-17" version="1">MVNENSTTITEFILQGISNDPGMKILLFVVFLFIYLVNVVGNLGMIILITLDSHLHNPMYFFLWHLSFCDICYSSAIAPRMLSDLLSESRTISFLECTAQFYFTAAFGDAECYILAVMAYDRYVAICNPLLYSTAMSKSLCIWLLLGSYIAGTTSAIIHTTATFSLQFCSSNLINHFFCDVPPLLAITCSDTHINEILLFAFAGFVAMSSLSIILLSYIFILAAVLRMPSGSLKAFSTCGSHFTGVALFYGTVIFMYLRPTSVYALDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFRKLINKKLNSHCIQIHHLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HSY6</accession>
    <name>A0A670HSY6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysocardiolipin acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LCLAT1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HSY6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003027.1">
        <property type="protein sequence ID" value="ENSPMRP00000002823.1"/>
        <property type="gene ID" value="ENSPMRG00000002038.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182836"/>
    <dbReference type="OMA" id="VANHVAW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="8">
        <location>
            <begin position="143"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="438" mass="51607" checksum="47842842EF123A6C" modified="2020-06-17" version="1">MLTCRHSGGRWQGKSNSTPWPAMTSWGSLAAIVFLQPSLFLSVVVKRKRQLEIFEGRAGDEYRAMVSWKGIYFVLTLFLGSFFGSIFMLGPLLPLMFFSPSWYRWITDRVVATWLTLPVALLEIVFGAKVVITGDGFIPGERSVIIMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKGIPGFGWAMQVAAFIFIHRRWEEDKNHFENMLDYFCDINEPLQLLIFPEGTDLTDNTKARSNEFAEKNGLQKYEYVLHPRTTGFTFIVERLRDGNNLDAIHDITVAYPQNIPQTEKHLLYGNFPKEIHFHVQRYPVQSLPTSREELQLWCQKRWEEKEERLRLFYEGKKYFDATGRSKIPPCKSEFRVMVVKCISLFYWTSFTLAMFVLLYLYSFVRWYFVILVVIFVMQQKAFGGLELLELACHRFFSKKLRNSERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HVH8</accession>
    <name>A0A670HVH8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Diacylglycerol kinase</fullName>
            <shortName evidence="31">DAG kinase</shortName>
            <ecNumber evidence="31">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="primary">DGKA</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="29">Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43428"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18155"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:78227"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:43429"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63324"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:72859"/>
            <dbReference type="ChEBI" id="CHEBI:82929"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:63325"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52595"/>
            <dbReference type="ChEBI" id="CHEBI:73332"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:44073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40403"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:77184"/>
            <dbReference type="ChEBI" id="CHEBI:77186"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:40404"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40407"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:77185"/>
            <dbReference type="ChEBI" id="CHEBI:77187"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40408"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75936"/>
            <dbReference type="ChEBI" id="CHEBI:78385"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41672"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:34115"/>
            <dbReference type="ChEBI" id="CHEBI:77580"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:64839"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:43417"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40323"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:40324"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2-(9Z-octadecenoyl)-glycerol + ATP = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:77593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:63329"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>a 1-O-alkyl-sn-glycerol + ATP = a 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15850"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58014"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.93"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:16938"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 31">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="31"/>
    <dbReference type="AlphaFoldDB" id="A0A670HVH8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003317.1">
        <property type="protein sequence ID" value="ENSPMRP00000003092.1"/>
        <property type="gene ID" value="ENSPMRG00000002074.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157144"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047649">
        <property type="term" value="F:alkylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046339">
        <property type="term" value="P:diacylglycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046834">
        <property type="term" value="P:lipid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00045593"/>
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        <source>
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        <source>
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    </evidence>
    <sequence length="713" mass="79126" checksum="9EBCEFCE15445552" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HX89</accession>
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        <name evidence="11" type="primary">OTX2</name>
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        <name type="scientific">Podarcis muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1 7 8">Nucleus</location>
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        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
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    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="289" mass="31592" checksum="EEF7235B004AAF85" modified="2020-06-17" version="1">MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKSSPAREVSSESGTSGQFTPPTSTSVPTISSSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGAALSPMGTNAVASHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXX4</accession>
    <name>A0A670HXX4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex of 4 set of homotrimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SFTPD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HXX4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004738.1">
        <property type="protein sequence ID" value="ENSPMRP00000004441.1"/>
        <property type="gene ID" value="ENSPMRG00000003039.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155748"/>
    <dbReference type="OMA" id="YQKVATF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.360:FF:000001">
        <property type="entry name" value="Pulmonary surfactant-associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000045">
        <property type="entry name" value="Pulmonary surfactant-associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.360">
        <property type="entry name" value="SFTPD helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015097">
        <property type="entry name" value="Surfac_D-trimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF15">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09006">
        <property type="entry name" value="Surfac_D-trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57944">
        <property type="entry name" value="Triple coiled coil domain of C-type lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0176">Collagen</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025686138" description="C-type lectin domain-containing protein" evidence="13">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="14">
        <location>
            <begin position="142"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="257" mass="27188" checksum="E6D38C1581C8204D" modified="2020-06-17" version="1">MLVLLTLSVLVSQFSPASFQGSPQVIQNLDRNACSLVVCGPAEKGLPGINGRDGVQGPKGDKGEQGLQGATGPQGPVGKPGSPGSKGDKGSVGDKGTKGDSGLSEVNLMKKQVSDLEGQLRALQASFSKYQKVAAFPGGRIVGNKVFVTSGYEGTFDDLKQKCLQAGGQLAAPKNAAENTAVQQIVVQHNKSVFLGVTDIQTEGKFRYLNGDAIVYSNWLQGEPNNEKGRENCVEVYVNGKWNDRACGEKRLILCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HYG9</accession>
    <name>A0A670HYG9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty acid binding protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FABP7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HYG9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004464.1">
        <property type="protein sequence ID" value="ENSPMRP00000004182.1"/>
        <property type="gene ID" value="ENSPMRG00000002861.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156713"/>
    <dbReference type="OMA" id="VAIRHYE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="162" mass="18518" checksum="B27C52CEB590191E" modified="2020-06-17" version="1">MVEAFCATWKLIDSQNFDEYMKALGVGFATRQVGNVTKPTVIICQEGGKVVIKTQSTFKNTEISFNLGEEFDETTADDRNCKSVVTMDGDKLVHVQKWDGKETNFVREIKDGKMVMKIHYFLLQTSNENSQHIIERPSPLVILLLFVSMKKHRNVNLLLEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ22</accession>
    <name>A0A670HZ22_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NRAS</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028590410.1">
        <property type="nucleotide sequence ID" value="XM_028734577.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028590411.1">
        <property type="nucleotide sequence ID" value="XM_028734578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HZ22"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005182.1">
        <property type="protein sequence ID" value="ENSPMRP00000004861.1"/>
        <property type="gene ID" value="ENSPMRG00000003341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599398"/>
    <dbReference type="KEGG" id="pmua:114599398"/>
    <dbReference type="CTD" id="4893"/>
    <dbReference type="GeneTree" id="ENSGT00940000158947"/>
    <dbReference type="OMA" id="RAVDIWG"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001938">
        <property type="term" value="P:positive regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="189" mass="21288" checksum="3382C7D8770AC529" modified="2020-06-17" version="1">MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSEDVPMVLVGNKCDLPTRTVDTKQAHEVAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKRLNSSEDGNQGCMGLSCLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ24</accession>
    <name>A0A670HZ24_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HZ24"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005281.1">
        <property type="protein sequence ID" value="ENSPMRP00000004954.1"/>
        <property type="gene ID" value="ENSPMRG00000003406.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158213"/>
    <dbReference type="OMA" id="LAHRHWS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000707">
        <property type="entry name" value="Cyclin dependent kinase 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8489" checksum="EE21501B0F681F6C" modified="2020-06-17" version="1">MDYEFKSKLAAERERVEDLFEYEGCKVGRGTYGHVFKARRKDGKDEKEYALKQIEGTGISMSACREIAVSEYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ63</accession>
    <name>A0A670HZ63_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Titin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HZ63"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005225.1">
        <property type="protein sequence ID" value="ENSPMRP00000004901.1"/>
        <property type="gene ID" value="ENSPMRG00000003366.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286978"/>
    <dbReference type="OMA" id="EYCATEY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
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        <property type="entry name" value="IGc2"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1"/>
            <end position="77"/>
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            <begin position="353"/>
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        <location>
            <begin position="448"/>
            <end position="558"/>
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    </feature>
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        <location>
            <begin position="516"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004901.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="69808" checksum="35DDD8ABBBF323A2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1A5</accession>
    <name>A0A670I1A5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="22">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">ATP8A2</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 22">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Membrane</location>
            <topology evidence="2 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 22">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="22"/>
    <dbReference type="RefSeq" id="XP_028582197.1">
        <property type="nucleotide sequence ID" value="XM_028726364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I1A5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005996.1">
        <property type="protein sequence ID" value="ENSPMRP00000005636.1"/>
        <property type="gene ID" value="ENSPMRG00000003832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595743"/>
    <dbReference type="CTD" id="51761"/>
    <dbReference type="GeneTree" id="ENSGT00940000157332"/>
    <dbReference type="OMA" id="KHTYKKT"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF98">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 21 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 22" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="913"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="960"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="998"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">Wiskott-Aldrich syndrome protein family member</fullName>
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        <name evidence="10" type="primary">WASF3</name>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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            <taxon>Podarcis</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="7">Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.</text>
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        <text evidence="7">Binds actin and the Arp2/3 complex.</text>
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            <begin position="182"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="502" mass="55481" checksum="8B5A4557ADF9A48A" modified="2020-06-17" version="1">MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNPVADIYNRSDKPPPLNILTSYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSIYHGASSEGSLSPDTRSHASDVTSYSYPATPNHSLHQQPMMPSYGAGDGAQYMLANQGLEHEFRPPSTTVRHATLNRPQQPPPPPPQAVDGSLGTVSLVPADYGMLAAQMVDYYNPSGPPPPPPPPMIPSAQTAFVSPLQIPVLPSHPGLVTGSIYSAALHPPSTGLVVTAPPPPGPPPPPPGPPAAGSSLSSSPMHAPALAEAKRHEPTQSPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSRRIAVEYSDSEDDSECDENDWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4M8</accession>
    <name>A0A670I4M8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I4M8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006796.1">
        <property type="protein sequence ID" value="ENSPMRP00000006375.1"/>
        <property type="gene ID" value="ENSPMRG00000004319.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154553"/>
    <dbReference type="OMA" id="KLYMITH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04373">
        <property type="entry name" value="RhoGAP_p190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000021">
        <property type="entry name" value="rho GTPase-activating protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051978">
        <property type="entry name" value="Rho-GAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="242" mass="27615" checksum="12D8F8DF68AC9388" modified="2020-06-17" version="1">MPLQDLVTSEKPIPLFVEKCVDFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNISLESMDVTVNAVAGALKAFFADLPDPLIPYSLHPELVEASKILDKTERLYELKEIVKKFHPVNYDVFRYVITHLNRVSQQSRTNLMTADNLSICFWPTLMRPDFENREFLSTTKILQSVIETFIQQCQFFFYNGEILETSDSVAHQPPPSNPVQMVDPIIPLQLPPPLQPQLIQPQLQADPLGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6S6</accession>
    <name>A0A670I6S6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor AP-2-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">AP-2 transcription factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Activating enhancer-binding protein 2-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Activator protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TFAP2A</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I6S6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007881.1">
        <property type="protein sequence ID" value="ENSPMRP00000007364.1"/>
        <property type="gene ID" value="ENSPMRG00000004984.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182848"/>
    <dbReference type="OMA" id="RSDCPQM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008121">
        <property type="entry name" value="TF_AP2_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01749">
        <property type="entry name" value="AP2ATNSCPFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="16">
        <location>
            <begin position="271"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="75"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="497" mass="53469" checksum="2BF31510B5744724" modified="2020-06-17" version="1">MDVTQQDAAGAEPPGPGEPGQLKGGGGAEAGSSESGSSRSKRAAGDAQLLALPFDGAAFAQPPPPEMLVHSFSAMDRHDGTSNGTGRLPQLGSVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQNQETGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHGLSSGLGDIPIHSIPHSLEDVPHVEDPGINIPDQTVIKKGPVSLSKSNANAVSSIPINKDTLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPTPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSTKSGDKEEKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8F7</accession>
    <name>A0A670I8F7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Establishment of sister chromatid cohesion N-acetyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ESCO1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
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            <dbReference type="ChEBI" id="CHEBI:57288"/>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
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        <property type="nucleotide sequence ID" value="XM_028737220.1"/>
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        <property type="nucleotide sequence ID" value="XM_028737221.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:mitotic sister chromatid cohesion"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-C2H2_3"/>
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    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
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    <feature type="region of interest" description="Disordered" evidence="11">
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    <feature type="region of interest" description="Disordered" evidence="11">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="31"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="55"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="410"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047902"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112795" checksum="3451BD9D5FC70DCB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8G1</accession>
    <name>A0A670I8G1_PODMU</name>
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        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RB associated KRAB zinc finger"/>
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        <property type="entry name" value="Uncharacterized protein"/>
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        <property type="entry name" value="Uncharacterized protein"/>
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        <property type="entry name" value="Zinc finger protein 33A"/>
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        <property type="entry name" value="Zinc finger protein 540"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 616"/>
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    </dbReference>
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        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
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        <property type="entry name" value="KRAB"/>
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        <property type="entry name" value="KRAB_dom_sf"/>
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        <property type="entry name" value="SCAN_dom"/>
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        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="KEGG" id="pmua:114597295"/>
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    <dbReference type="OrthoDB" id="8990338at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030485">
        <property type="term" value="C:smooth muscle contractile fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072144">
        <property type="term" value="P:glomerular mesangial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014829">
        <property type="term" value="P:vascular associated smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0558">Oxidation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="377" mass="42009" checksum="2D0543262DB35CA5" modified="2020-06-17" version="1">MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IC42</accession>
    <name>A0A670IC42_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">ITGB5</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Heterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10. Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus). ITGAV:ITGB5 interacts with CCN3. Interacts with tensin TNS3; TNS3 also interacts with PEAK1, thus acting as an adapter molecule to bridge the association of PEAK1 with ITGB5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Cell membrane</location>
            <topology evidence="1 22">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028599518.1">
        <property type="nucleotide sequence ID" value="XM_028743685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IC42"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009822.1">
        <property type="protein sequence ID" value="ENSPMRP00000009199.1"/>
        <property type="gene ID" value="ENSPMRG00000006175.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604009"/>
    <dbReference type="KEGG" id="pmua:114604009"/>
    <dbReference type="CTD" id="3693"/>
    <dbReference type="GeneTree" id="ENSGT01150000286919"/>
    <dbReference type="OMA" id="CVMLFTY"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034684">
        <property type="term" value="C:integrin alphav-beta5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035987">
        <property type="term" value="P:endodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090136">
        <property type="term" value="P:epithelial cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043149">
        <property type="term" value="P:stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000006">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000043">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000075">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000258">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.30:FF:000001">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF26">
        <property type="entry name" value="INTEGRIN BETA-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07965">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
        <property type="entry name" value="Integrin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69687">
        <property type="entry name" value="Integrin beta tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR619502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR619502-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="893" mass="100044" checksum="4D6D642B0023CEBC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDP4</accession>
    <name>A0A670IDP4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A670IDP4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010477.1">
        <property type="protein sequence ID" value="ENSPMRP00000009831.1"/>
        <property type="gene ID" value="ENSPMRG00000006577.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012914"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="97" mass="10786" checksum="DB23AA9EFF852142" modified="2020-06-17" version="1">MAAVLAEGSAGGAESEAAAVPPMAGLEMVQQGAEARVYRGLFLGWPTVAKHRFPKRYRHPLLEERLSRRRTAQEARSLLRCRRAGKEAEDWLWKAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEB5</accession>
    <name>A0A670IEB5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPI fold containing family B member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BPIFB2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IEB5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010754.1">
        <property type="protein sequence ID" value="ENSPMRP00000010091.1"/>
        <property type="gene ID" value="ENSPMRG00000006743.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263546"/>
    <dbReference type="OMA" id="RYSMINA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051660">
        <property type="entry name" value="BPI_fold-BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46019:SF1">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46019">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025439997" evidence="1">
        <location>
            <begin position="20"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="3">
        <location>
            <begin position="254"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="461" mass="49542" checksum="AB32C98A4C0B9AD5" modified="2020-06-17" version="1">MLKLCVLSVLLCLLVPSQGSTPGTVVRVNQEALEYVCQQGKPSLLRGLMVIQIPNFMSPRTIIGSLLKVVGIRVLNAQLPHLSVKLIPRTGVQLSLSAQLHIRGSVLIAPVELRVGSSILLDVRVMRSPHGFPILSVTACKSLLGDVDILLGGSNLLGFLKPLQNHIRAVLVDKMCLSLSSVVLGLNARLGTLVGLNSINPMSSLQYAMMEDPEITEDYIDLDLNAVIALMGKPVDFEPAGPLPPFSLPPPETVSDDSMVNMGLSEHLFASLFASLEQSGALNLQIGGQSSHLTTSMLEQAIPSISKRYPQAVALMLNVVVSKLPIISFHEGAAILRLSPAIQVGVAESGSFQQSQALFTLGVDLTLAVKLDVTITSLHLTVAIHGDVGLEVESSSVEITEISYLRRVVLSEFQDAFLAHVNAALRVGISLPKLNNVQYIEPEIEIHEGYAQVNCDLDYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEC8</accession>
    <name>A0A670IEC8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alsin Rho guanine nucleotide exchange factor ALS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ALS2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028557359.1">
        <property type="nucleotide sequence ID" value="XM_028701526.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000010769.1">
        <property type="protein sequence ID" value="ENSPMRP00000010106.1"/>
        <property type="gene ID" value="ENSPMRG00000006747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581415"/>
    <dbReference type="KEGG" id="pmua:114581415"/>
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        <location>
            <begin position="437"/>
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        <location>
            <begin position="448"/>
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    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1649" mass="182507" checksum="A0697EB66C624AED" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEK6</accession>
    <name>A0A670IEK6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nanos C2HC-type zinc finger 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NANOS1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the nanos family.</text>
    </comment>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:epithelial cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12887">
        <property type="entry name" value="NANOS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="269"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="279" mass="30215" checksum="0D746B6D17A4F68F" modified="2020-06-17" version="1">YLLRIKSLRKPRRRLRPAFLPGGARYGAKSHGAYGNAFNSWNDYLGLATLVTKAVSQQEKGFRGGASSVVVAATVQQVEEDDEEDDDEEEGGGGRRRGGSALDLRDFDLCSHHHHHHHHLSPGESLLEERFADFSPFSGRASPASSVVFSCSSDPLEKERSAAHAWPGGGGGRLVVDGRLHPAAAPKTGSRLLKPELQVCVFCRNNKEAVALYTTHILKGPDGRVLCPVLRRYTCPLCGASGDNAHTIKYCPLSKMHGGGSAPKQPLKSARHILGKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFN6</accession>
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        <submittedName>
            <fullName evidence="5">Vitrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">VIT</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IFN6"/>
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        <property type="protein sequence ID" value="ENSPMRP00000010543.1"/>
        <property type="gene ID" value="ENSPMRG00000007003.1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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        <property type="entry name" value="ECM_Assembly_Org"/>
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        <property type="entry name" value="LCCL"/>
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        <property type="entry name" value="LCCL_sf"/>
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        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF23">
        <property type="entry name" value="VITRIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="vWA-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="4">
        <location>
            <begin position="42"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="179"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="381"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="564" mass="62675" checksum="1EC5E0C0B8A2A772" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IMI7</accession>
    <name>A0A670IMI7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hyaluronan synthase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HAS3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028595727.1">
        <property type="nucleotide sequence ID" value="XM_028739894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IMI7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014223.1">
        <property type="protein sequence ID" value="ENSPMRP00000013323.1"/>
        <property type="gene ID" value="ENSPMRG00000008912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602088"/>
    <dbReference type="CTD" id="3038"/>
    <dbReference type="GeneTree" id="ENSGT00390000010337"/>
    <dbReference type="OMA" id="HTEQHYL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036117">
        <property type="term" value="C:hyaluranon cable"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900106">
        <property type="term" value="P:positive regulation of hyaluranon cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF6">
        <property type="entry name" value="HYALURONAN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="548" mass="62794" checksum="CF975EE301EA3548" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IMY0</accession>
    <name>A0A670IMY0_PODMU</name>
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        <submittedName>
            <fullName evidence="5">INO80 complex subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">INO80D</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028702133.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028702141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IMY0"/>
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        <property type="protein sequence ID" value="ENSPMRP00000013488.1"/>
        <property type="gene ID" value="ENSPMRG00000009029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581691"/>
    <dbReference type="KEGG" id="pmua:114581691"/>
    <dbReference type="CTD" id="54891"/>
    <dbReference type="GeneTree" id="ENSGT00940000157974"/>
    <dbReference type="OMA" id="SWRPQNG"/>
    <dbReference type="OrthoDB" id="10038011at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of telomere maintenance in response to DNA damage"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of DNA replication"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060382">
        <property type="term" value="P:regulation of DNA strand elongation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of embryonic development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16198:SF2">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT D"/>
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    </dbReference>
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        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
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    </dbReference>
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            <end position="78"/>
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            <end position="516"/>
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            <end position="228"/>
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            <end position="581"/>
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    </feature>
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            <end position="852"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="530"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="920"/>
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        </location>
    </feature>
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        <location>
            <begin position="934"/>
            <end position="948"/>
        </location>
    </feature>
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        <location>
            <begin position="1008"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13891"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013488.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1034" mass="113989" checksum="3108E759D7BC5B82" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IN58</accession>
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        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
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        <property type="protein sequence ID" value="ENSPMRP00000013583.1"/>
        <property type="gene ID" value="ENSPMRG00000009105.1"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000030">
        <property type="entry name" value="Zinc finger protein 628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002075">
        <property type="entry name" value="zinc finger protein 646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000180">
        <property type="entry name" value="Zinc finger protein 689"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="266" mass="30183" checksum="26C4EF1AEFC3A16C" modified="2020-06-17" version="1">MFGFRKNVCKPEHLLLGLRRSGAKTCEYQGVRELRLTGPEREHQVAFARGSVFTARHGVTQACPAPPPPPPAVLPSERPYQCKDCGKRFVYRSKLATHQWTHCAERPYKCPDCPKSFSYPSKLAAHRRTHTGERPYPCTLCPKRFGHRSKLAAHQWIHTPERPYKCADCPKSFCYPSKLAAHRRTHTGQRPYPCNRCGKSFCYPSKLAAHQQIHAAAAAGRPYPCMRCSKSFRQLRNLTLHQRVHEDGEVGDDLSQSKGHSNGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INK2</accession>
    <name>A0A670INK2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide deformylase</fullName>
            <ecNumber evidence="7">3.5.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PDF</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 7">Removes the formyl group from the N-terminal Met of newly synthesized proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N-terminal N-formyl-L-methionyl-[peptide] + H2O = N-terminal L-methionyl-[peptide] + formate</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028595712.1">
        <property type="nucleotide sequence ID" value="XM_028739879.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028595713.1">
        <property type="nucleotide sequence ID" value="XM_028739880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670INK2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014119.1">
        <property type="protein sequence ID" value="ENSPMRP00000013226.1"/>
        <property type="gene ID" value="ENSPMRG00000008856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602083"/>
    <dbReference type="KEGG" id="pmua:114602083"/>
    <dbReference type="CTD" id="64146"/>
    <dbReference type="GeneTree" id="ENSGT00390000018698"/>
    <dbReference type="OMA" id="ILYPMRI"/>
    <dbReference type="OrthoDB" id="276063at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.45.10:FF:000003">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001159">
        <property type="entry name" value="PRK00150.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PEPTIDE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458:SF2">
        <property type="entry name" value="PEPTIDE DEFORMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="241" mass="27183" checksum="AC9D9CFC492E528C" modified="2020-06-17" version="1">MAVCRLRPGLAWMLDSLRWNRAFLAPLPCRSCSHTCSSPAEKQRTYWQYLRRKVLKPPTPPYSHVCQVGDPILRSLAAPVEPSQIASGEVQTLIRTLVRVMRKEQCVGLSAPQVGVPLQIFVAEFPERLFYEHTPSMRQACQMAPFPLHVVVNPSMRVLDSQLVSFPEGCKSISGFSACVARYQAVAVSGLNEVGEQFSWPASGWAARIIQHEMDHLQGVLYIDKMDSRTFVNLQWEQLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INL2</accession>
    <name>A0A670INL2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Nuclear factor of activated T-cells 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">T-cell transcription factor NFAT5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">NFAT5</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer when bound to DNA, completely encircles its DNA target. Interacts with CIDEC; this interaction is direct and retains NFAT5 in the cytoplasm. Does not bind with Fos and Jun transcription factors. Interacts with DDX5 and DDX17; this interaction leads to DDX5/DDX17 recruitment to LNC2 and S100A4 promoters and NFAT5-mediated DDX5/DDX17-enhanced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028595654.1">
        <property type="nucleotide sequence ID" value="XM_028739821.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000013708.1">
        <property type="protein sequence ID" value="ENSPMRP00000012837.1"/>
        <property type="gene ID" value="ENSPMRG00000008583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602057"/>
    <dbReference type="KEGG" id="pmua:114602057"/>
    <dbReference type="CTD" id="10725"/>
    <dbReference type="GeneTree" id="ENSGT00940000155213"/>
    <dbReference type="OMA" id="PYQNQVI"/>
    <dbReference type="OrthoDB" id="5346094at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071345">
        <property type="term" value="P:cellular response to cytokine stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904996">
        <property type="term" value="P:positive regulation of leukocyte adhesion to vascular endothelial cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070884">
        <property type="term" value="P:regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01178">
        <property type="entry name" value="IPT_NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07882">
        <property type="entry name" value="RHD-n_TonEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000174">
        <property type="entry name" value="Nuclear factor of activated T-cells 5, tonicity-responsive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000002">
        <property type="entry name" value="Nuclear factor of activated T-cells 5, tonicity-responsive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008366">
        <property type="entry name" value="NFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015646">
        <property type="entry name" value="NFAT5_RHD_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533">
        <property type="entry name" value="NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533:SF10">
        <property type="entry name" value="NUCLEAR FACTOR OF ACTIVATED T-CELLS 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Podarcis muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with PIP5K1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Lipid-anchor</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="19"/>
    <dbReference type="RefSeq" id="XP_028587409.1">
        <property type="nucleotide sequence ID" value="XM_028731576.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028587410.1">
        <property type="nucleotide sequence ID" value="XM_028731577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IR94"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014987.1">
        <property type="protein sequence ID" value="ENSPMRP00000014024.1"/>
        <property type="gene ID" value="ENSPMRG00000009383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597981"/>
    <dbReference type="KEGG" id="pmua:114597981"/>
    <dbReference type="CTD" id="5337"/>
    <dbReference type="GeneTree" id="ENSGT00940000155015"/>
    <dbReference type="OMA" id="EWRLDQI"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098981">
        <property type="term" value="C:cholinergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031670">
        <property type="term" value="P:cellular response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032534">
        <property type="term" value="P:regulation of microvillus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098693">
        <property type="term" value="P:regulation of synaptic vesicle cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09844">
        <property type="entry name" value="PLDc_vPLD1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07296">
        <property type="entry name" value="PX_PLD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000114">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000021">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000005">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000009">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000018">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF57">
        <property type="entry name" value="PHOSPHOLIPASE D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 19" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="22">
        <location>
            <begin position="79"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="21">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="21">
        <location>
            <begin position="856"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="497"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1038" mass="119173" checksum="312D1DC385345B98" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRE3</accession>
    <name>A0A670IRE3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IRE3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014705.1">
        <property type="protein sequence ID" value="ENSPMRP00000013762.1"/>
        <property type="gene ID" value="ENSPMRG00000009230.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000273794"/>
    <dbReference type="OMA" id="ASIWRNM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="116" mass="12585" checksum="21158C9392D5F04C" modified="2020-06-17" version="1">MEQEASASGPQQPACKEEAPSAEPGALDCVICFTPYDRLFRLPKELSCGHIFCLECLARINVSSEDVNALTCPICRAPTAFPSRKGLPGLPTRCDLLEILTAAIRGHVASIWRNMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRP3</accession>
    <name>A0A670IRP3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor AP-2 epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TFAP2E</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IRP3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015780.1">
        <property type="protein sequence ID" value="ENSPMRP00000014773.1"/>
        <property type="gene ID" value="ENSPMRG00000009858.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182848"/>
    <dbReference type="OMA" id="QEAGYPH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF13">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2-EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="198"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="424" mass="45934" checksum="2CE9F32787D0502E" modified="2020-06-17" version="1">IGFHYFSPCRLSQLSSLNQAAAYSSAPPLCHTPASDFQPPYFPPPYPQPPLPYSQSQETGYPHLGDPYTAINPIHQHQQSSWHSQRARQEEAAAGLLSQTHRALGLDPRRDYPGVPRLLHGLADGAHALSDGPLGLHALGHHSIEDIQAVDETGMNLLDQSVIKKVPIPSKANGTSISALSMNKDTLIGGVTNPNEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLCRQHSDPGELHARKNMLLATKQICKEFADLMAQDRSPLGNSRPSLILEPGVQSCLTHFSLITHGFGGPAICAALTAFQNYLVESLKGLDKMFMNSTGNGHPVGDSKTSEKEVKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITW3</accession>
    <name>A0A670ITW3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ITW3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016429.1">
        <property type="protein sequence ID" value="ENSPMRP00000015380.1"/>
        <property type="gene ID" value="ENSPMRG00000010254.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000245180"/>
    <dbReference type="OMA" id="HYCETRR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="54" mass="6560" checksum="9037539A7E41472D" modified="2020-06-17" version="1">MTNSKGKRKGTRYMFSRQFRKHGHAPQMLLWQDWKDIQHYPACCGHYCETRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUH2</accession>
    <name>A0A670IUH2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">StAR related lipid transfer domain containing 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">STARD6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028604602.1">
        <property type="nucleotide sequence ID" value="XM_028748769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IUH2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016928.1">
        <property type="protein sequence ID" value="ENSPMRP00000015853.1"/>
        <property type="gene ID" value="ENSPMRG00000010581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606464"/>
    <dbReference type="KEGG" id="pmua:114606464"/>
    <dbReference type="CTD" id="147323"/>
    <dbReference type="GeneTree" id="ENSGT00940000161788"/>
    <dbReference type="OMA" id="YEGNMDI"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043556">
        <property type="entry name" value="StARD5/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46374">
        <property type="entry name" value="PROTEIN CBG07384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46374:SF2">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="211" mass="23592" checksum="060B15C68259EA5C" modified="2020-06-17" version="1">MDYKKLSEGLSIKIFSYLHDPVGWKVVKSAKQISVSSRPSTDFPGTLYRAEALVEVPAPKLFPFIFRAEYRNKWDRAVQSYKLVDTIDQDTFVYQSITHSYGLGLVTPRDFVYLLHVKTYDGDLLTTNSVSVDHPAFPPTPKYVRGTNYPSGYACCPIPGNPEHSKFVAIVQVDLGGKLMPSVIDSVMPMSIMNMIMDFKAGIKSLKGNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWG4</accession>
    <name>A0A670IWG4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PTPN1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670IWG4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016876.1">
        <property type="protein sequence ID" value="ENSPMRP00000015804.1"/>
        <property type="gene ID" value="ENSPMRG00000010556.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158041"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903898">
        <property type="term" value="P:negative regulation of PERK-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14608">
        <property type="entry name" value="PTPc-N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000025">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051985">
        <property type="entry name" value="NR_tyrosine_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047:SF2">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="206"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="392"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="494"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="556"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="652" mass="73675" checksum="2F980F979ADDBB61" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWT3</accession>
    <name>A0A670IWT3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114584416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IWT3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016687.1">
        <property type="protein sequence ID" value="ENSPMRP00000015627.1"/>
        <property type="gene ID" value="ENSPMRG00000010426.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163951"/>
    <dbReference type="OMA" id="FVFHFFG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15939">
        <property type="entry name" value="7tmA_OR4A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="310" mass="35017" checksum="CEB1E10CB6F39B0D" modified="2020-06-17" version="1">MANRNNVSEFIFLGLTTDQDLQKACFAIFLVLYVAILTGNVLIIATVKSSSRLNSPMYFLLSYLSFVDIGYSSATAPKLIADFLVEKKIISFAGCMTQLFVFHFFGVTEIFLLTVMAYDRYIAICKPLHYTTIMSKSVCKWTMRALWLGAFAHSMVQTLLTLHLPFCGPNEIDHYFCDVHPLLKLACTDTYIVAYVVIVNSGMVSLVSFVLLTISYIIILVTLRSRSSEGRLKALSTCGSHITVVILFFVPCIFIYLRPSTTFSEDKGVAVFYTIITPMLNPLIYTLRNEEVKNAMRKLWRHCNKGTVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWV2</accession>
    <name>A0A670IWV2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114593322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GST superfamily. Alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028577524.1">
        <property type="nucleotide sequence ID" value="XM_028721691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IWV2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016711.1">
        <property type="protein sequence ID" value="ENSPMRP00000015647.1"/>
        <property type="gene ID" value="ENSPMRG00000010450.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593322"/>
    <dbReference type="KEGG" id="pmua:114593322"/>
    <dbReference type="GeneTree" id="ENSGT00940000161750"/>
    <dbReference type="OMA" id="HYLPIFE"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03208">
        <property type="entry name" value="GST_C_Alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000005">
        <property type="entry name" value="Glutathione S-transferase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003080">
        <property type="entry name" value="GST_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF230">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01266">
        <property type="entry name" value="GSTRNSFRASEA"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="223" mass="25341" checksum="7EC49BFA5577048A" modified="2020-06-17" version="1">MSGKPKLTYFEGRGRMESIRWLLAAAGVEFEETFLKTREQYLKLIKDGYLLFDQVPLVEMDGLKLVQTKAILNYIAGKYNLHGKNLKERAHIDMYVEGTMDLMGMILVYSFSPPEQKEKQLASVLEKATTRYFPVYEKALKQPGQEFLVGNRLSFADVQLLEAILMVEELKADVLAPFPQLQAFKARASNLPAIKKFLQPGSQRKPPPDDAYVATVREVFASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IY10</accession>
    <name>A0A670IY10_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HEXIM P-TEFb complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HEXIM1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028559101.1">
        <property type="nucleotide sequence ID" value="XM_028703268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IY10"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017417.1">
        <property type="protein sequence ID" value="ENSPMRP00000016319.1"/>
        <property type="gene ID" value="ENSPMRG00000010892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582327"/>
    <dbReference type="KEGG" id="pmua:114582327"/>
    <dbReference type="CTD" id="10614"/>
    <dbReference type="GeneTree" id="ENSGT00390000002808"/>
    <dbReference type="OMA" id="LQEQGYC"/>
    <dbReference type="OrthoDB" id="10058500at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120259">
        <property type="term" value="C:7SK snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097322">
        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106140">
        <property type="term" value="F:P-TEFb complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032897">
        <property type="term" value="P:negative regulation of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901798">
        <property type="term" value="P:positive regulation of signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02094">
        <property type="entry name" value="HEXIMFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
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        <location>
            <begin position="49"/>
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        <location>
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        <location>
            <begin position="233"/>
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        <location>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="356" mass="40146" checksum="2939C67F302BA526" modified="2020-06-17" version="1">MADAALSASQQQPNGKTSSFSPCKDASSGEGPFLVSPPASREVLQGEAMDGRWQPRETKQQDGSPMSRDEEACRDAEHAVPPVGRSLGAPEGAVGGEVEDQNCGAPADVQKPCDGEQLGLQCQAYSGPVGQRFRPQAEGDEEEKLVKKKHRRRPSKKKRHWKPYYKLSWEEKKKFDEKQSQRASRLRAEMFAKGQPVAPYNTTQFLMEDHDQEEPDLKTGLFPKKTAAKSDDTSEEDFFVEEEGGGSDGMGGDGSEFLQKDFSETYEKYHVESLQNMSKQELITEYLELEKCLSRMEEENNRLRMENKKFLGDSTEDPRVSQLEEELGRLRAENQKLLKENELSRQQEKAFPKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IYV3</accession>
    <name>A0A670IYV3_PODMU</name>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IYV3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RT_POL"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="421"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="875" mass="100107" checksum="7A6838EF7A5DD9AE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J015</accession>
    <name>A0A670J015_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">P4HA2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028573828.1">
        <property type="nucleotide sequence ID" value="XM_028717995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J015"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018690.1">
        <property type="protein sequence ID" value="ENSPMRP00000017555.1"/>
        <property type="gene ID" value="ENSPMRG00000011605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591257"/>
    <dbReference type="CTD" id="8974"/>
    <dbReference type="GeneTree" id="ENSGT00940000157695"/>
    <dbReference type="OMA" id="VIWMEEA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025574104" description="procollagen-proline 4-dioxygenase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="16">
        <location>
            <begin position="414"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="535" mass="61301" checksum="FECD3C749015FF02" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1R6</accession>
    <name>A0A670J1R6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">E3 ubiquitin-protein ligase RNF14</fullName>
            <ecNumber evidence="5">2.3.2.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">RING finger protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">RNF14</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with GCN1; interaction takes place in response to ribosome collisions and is required for ubiquitination of EEF1A1/eEF1A. Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2. Interacts with AR/androgen receptor. Interacts with TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4; promoting Wnt signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670J1R6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018426.1">
        <property type="protein sequence ID" value="ENSPMRP00000017307.1"/>
        <property type="gene ID" value="ENSPMRG00000011457.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154507"/>
    <dbReference type="OMA" id="PRSWCQG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160127">
        <property type="term" value="P:protein-RNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060765">
        <property type="term" value="P:regulation of androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20341">
        <property type="entry name" value="BRcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16628">
        <property type="entry name" value="RING-HC_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000011">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000049">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000186">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031128">
        <property type="entry name" value="RNF14_RING-HC_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="24">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="25">
        <location>
            <begin position="209"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="213"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="477" mass="54109" checksum="A86EEADDFF5979B7" modified="2020-06-17" version="1">MSSEDKEAQEDELLALASIYDEDEFKRAQSVQGGETRISVELPPGFTICMSGNLTENLQNSKFECRVCFLPPIVLHFEFPPDYPSTSPPVFTLSSKWLSQAQLSALCKHLDNLWEENRGCVILFAWMQFLKEETLTYLNISSPYEPEICDQGQEQSRKGKEDGAGAAAAAAHEEALDARAVQDVESLSSLIREILDFDQAQRQKCFNSKMYTCNVCFSEKLGSECMYFMECRHVYCRACLKDYFEIKIKDGEVHYLNCPEPKCPSVATPGQVKELVEEELFARYDRLLLQSSLDMMADVVYCPRPCCQTPVMQEPSGTMGICSRCNYAFCTLCKMTYHGVSRCKVTAGKPGAFSDTLDPEKLADLRKEYLEADEATQKFLEQRYGKRVIQKTLEEMDSKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTACTQYFCWLCMGSLPRGNPYMHFNDPASPCFNRLFRGGEDDGNFWEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1V4</accession>
    <name>A0A670J1V4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAX dimerization protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MXD1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028597032.1">
        <property type="nucleotide sequence ID" value="XM_028741199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J1V4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019643.1">
        <property type="protein sequence ID" value="ENSPMRP00000018478.1"/>
        <property type="gene ID" value="ENSPMRG00000012129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602683"/>
    <dbReference type="CTD" id="4084"/>
    <dbReference type="GeneTree" id="ENSGT00940000159446"/>
    <dbReference type="OMA" id="SSTHNEM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070443">
        <property type="term" value="C:Mad-Max complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18931">
        <property type="entry name" value="bHLHzip_Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000014">
        <property type="entry name" value="Max dimerization protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040157">
        <property type="entry name" value="MXD1_bHLHzip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF18">
        <property type="entry name" value="MAX DIMERIZATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="224" mass="25459" checksum="9A5799EC2DBD6D13" modified="2020-06-17" version="1">MAAAAQVCENIQMLLEAAEFLERREREAEHGYASMLPYSSKDRDALKRRNKSKKNSSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDYDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSDRSDSDREEIDVDVESTDYLTGDLDWSSSSSPSDLDERGSLQSVCSDEGYSSAGIKRIKLQNNLKACLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2F4</accession>
    <name>A0A670J2F4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Platelet-derived growth factor C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PDGFC</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PDGF/VEGF growth factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J2F4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019849.1">
        <property type="protein sequence ID" value="ENSPMRP00000018683.1"/>
        <property type="gene ID" value="ENSPMRG00000012257.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158645"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005161">
        <property type="term" value="F:platelet-derived growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048008">
        <property type="term" value="P:platelet-derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048146">
        <property type="term" value="P:positive regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00135">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000010">
        <property type="entry name" value="Platelet derived growth factor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11633">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11633:SF5">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-0497">Mitogen</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="14">
        <location>
            <begin position="232"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="346" mass="37956" checksum="1F28A23E630F19B1" modified="2020-06-17" version="1">MGLCGNYPALLGCSSRLSAAAAAAAAAPFSPALQASRAGGGGEKDLISRQVPGLRCVPAKSFNPPSLPNAPLRVLLADICPGQPKTGSPRRVEPQQQVPVLQRQGAKRYDFVEVEEPSDGTILGRWCGSTTVPGKQISKGNQIRIRFVSDEYFPSEPGFCIHYTLLVPTESASPTILPPSALPLELLNNAVAGFSTVEELIKYLEPDRWQLDLEDLYRPTWQLLGKAYIHGRKSRVVDLNLLKEEVRMYSCTPRNYSVSLREELKRTDTIFWPLCLLVKRCGGNCGCCQHACSECQCVPTKVTKKYHEVLQLKPRSGVKGLHKSLTDVPLDHHEECDCVCKGNTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J450</accession>
    <name>A0A670J450_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">TIR domain-containing adapter molecule 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">TRIF-related adapter molecule</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs in late endosomes and disrupts the interaction between isoform 1 and TICAM1. Interacts with MYD88; the interaction decreases after IL-18 stimulation in a time-dependent manner. Interacts with IL18R1 and IL18RAP. Interacts with TLR2. Interacts with RAB11FIP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Phagocytic cup</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J450"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019477.1">
        <property type="protein sequence ID" value="ENSPMRP00000018314.1"/>
        <property type="gene ID" value="ENSPMRG00000012053.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165590"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001891">
        <property type="term" value="C:phagocytic cup"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071651">
        <property type="term" value="P:positive regulation of chemokine (C-C motif) ligand 5 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000494">
        <property type="term" value="P:positive regulation of interleukin-18-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035666">
        <property type="term" value="P:TRIF-dependent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000014">
        <property type="entry name" value="TIR domain-containing adapter molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046946">
        <property type="entry name" value="TCAM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47230">
        <property type="entry name" value="TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47230:SF2">
        <property type="entry name" value="TIR DOMAIN-CONTAINING ADAPTER MOLECULE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0391">Immunity</keyword>
    <keyword evidence="18" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="11" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="26">
        <location>
            <begin position="132"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00056963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00063028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00072691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00080195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="295" mass="33751" checksum="B7F7E0822D9D924A" modified="2020-06-17" version="1">MSCFPFSQQRPDVKGAETQRLPATTSSGGEKLDVPGRLRRGEKDQAHLLDRLEKLGYLIVFRSGCFAAMGNGNSKRTFPFSPRNSVKDNRASPGQEGFKQKPKTFELSLGEETSGNTNTEEIHSSDEDAGDVFYRFVVLHAEEDVEEAARVQDLLQNEFCIKPGIIFAEMPGGRHLFENLNDAMNGSAWIIILLTENFLSELWCEFQFCTCLFSALTIPHKGYTVIPMRPRNNPLPRERTPFILQTINTLQEDSPGFAQQVKNIFQDSRYRQQQAIWQYEKKKEEVQKLLEWQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5Q7</accession>
    <name>A0A670J5Q7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J5Q7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020821.1">
        <property type="protein sequence ID" value="ENSPMRP00000019601.1"/>
        <property type="gene ID" value="ENSPMRG00000012799.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163565"/>
    <dbReference type="OMA" id="IHFLKHA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF32">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="46"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="338" mass="38363" checksum="8613747A1E848388" modified="2020-06-17" version="1">MIWRILDVWISPKHYQGLIIKDLVFDGVPVRVHWPQTSPAENRRGVMYFHGGIALFGTMRAFERTCCYIAHQSESVVVNVNFRLAPEHLYPTPALDCRTAAIHFLKHAKEYGVDPNRIAIGGDSGGGTIAAAVCQQLVARKDLPRVRAQFLVYPFLQAVDFNLPSYQQNRSIPLLFRKRAVKHGFKYLTGKMINVDGIIKGAHVSADIWLKHRKWISADNIPEEFKGRGYVPAVPPPFSEKLHELCKRGFETMFSPLLAEDNIICQLPETFILTFEYDLIRDDGLLYKKRLEDNGVPVTWHHLQDGFHGITVSFGLGPFEFPAARKCLQHVADFLKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5S0</accession>
    <name>A0A670J5S0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein subunit beta 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GNB2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028558502.1">
        <property type="nucleotide sequence ID" value="XM_028702669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J5S0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019788.1">
        <property type="protein sequence ID" value="ENSPMRP00000018622.1"/>
        <property type="gene ID" value="ENSPMRG00000012223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581940"/>
    <dbReference type="KEGG" id="pmua:114581940"/>
    <dbReference type="CTD" id="2783"/>
    <dbReference type="GeneTree" id="ENSGT01000000214413"/>
    <dbReference type="OMA" id="SCCRFLT"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="340" mass="37485" checksum="CBC492D2EAA3F3F0" modified="2020-06-17" version="1">MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLNDNQIITSSGDTTCALWDIETGQQTTAFTGHSGDVMSLSLAPDMRTFVSGACDASIKLWDIRDSMCRQTFTGHESDINAVCFFPNGNAFTTGSDDATCRLFDLRADQELMMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDSMKGDRAGVLAGHDNRVSCLGVTDDGMAIATGSWDSFLKVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J7N2</accession>
    <name>A0A670J7N2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">ADAM metallopeptidase with thrombospondin type 1 motif 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ADAMTS17</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028561173.1">
        <property type="nucleotide sequence ID" value="XM_028705340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J7N2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021454.1">
        <property type="protein sequence ID" value="ENSPMRP00000020205.1"/>
        <property type="gene ID" value="ENSPMRG00000013159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114583953"/>
    <dbReference type="KEGG" id="pmua:114583953"/>
    <dbReference type="CTD" id="170691"/>
    <dbReference type="GeneTree" id="ENSGT00940000158773"/>
    <dbReference type="OMA" id="GCYEWRT"/>
    <dbReference type="OrthoDB" id="10035764at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
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        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
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        <property type="entry name" value="ADAM_Cys-rich"/>
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        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
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        <property type="entry name" value="Peptidase_M12B"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 17"/>
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        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="TSP_1"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
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        <property type="entry name" value="ACR"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TSP-1 type 1 repeat"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13 17 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
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        </location>
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        <location>
            <position position="202"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="390"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    </feature>
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        <location>
            <position position="394"/>
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        <ligand>
            <name>Zn(2+)</name>
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        <location>
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        <ligand>
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        </ligand>
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        <ligand>
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    <sequence length="1145" mass="127717" checksum="D15BE74841A9F046" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8Z6</accession>
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        <submittedName>
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        <name evidence="2" type="primary">LOC114605316</name>
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        <lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <sequence length="304" mass="33108" checksum="13853C791956F457" modified="2020-06-17" version="1">MPPMETEAPPCIRPEGALAEDRSEGSPEASHASQPPGTAVTPISRTVCLYRPVGTFADSQPLVLLLPWFGARPGALAKYLSLYLGRGWAVLVAESSLGHFLWPRWGLAYADQLLGLLGEGKALGTQPLLIHAFSIGGYTFAQMMVHLARHPERHAGIGERICGCVYDSLVAGSLENMAQGVARMTSSSAAVRPLLRGGALLYFRLFRLCTVAHYEAALGAFHHPPLRCPVLVFFCHNDPLSDARTMQQLLGAWRALGLRVQVQEWAVSRHAQHLRLYPQEYSRALGAFLQQLGLLPTSGLQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1 14">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the histone H4 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone, subunit A"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
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        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
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        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0164">Citrullination</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 14" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="16">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="109" mass="12127" checksum="53291C713C60BA08" modified="2020-06-17" version="1">ISGRGIYQQKSKSGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAA6</accession>
    <name>A0A670JAA6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JAA6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021376.1">
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        <property type="gene ID" value="ENSPMRG00000013120.1"/>
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    <dbReference type="GeneTree" id="ENSGT01030000234535"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:oligosaccharide metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF29">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE 8F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="65"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30871" checksum="CA4DE66EFED20E6C" modified="2020-06-17" version="1">MAQYRAELGQCCNASFSIVLTKENTPLGSSITFDGMKGKAFPASAKLVDLLPERSPFPDSQYRHCAVVGNGGILRNSSCGQEIDRADLVIRFNLPPMNFSEDVGTKSDLVTLNPSILNENFQRLSDRRKPFADSLRLYGGAFFLIPAFSFVGHTDVSYRALYTMEDFGLAQRALFLNPHYLAPLGSYWKSRGLGPKRLSSGFMFTSMALELCERITLYGFWPFQHDLENQPILHHYYDNRLPKQGVHEMPSEFSRYLDMYAQGLLRLRLGKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAJ3</accession>
    <name>A0A670JAJ3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA polymerase II subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">POLR2I</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JAJ3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021972.1">
        <property type="protein sequence ID" value="ENSPMRP00000020689.1"/>
        <property type="gene ID" value="ENSPMRG00000013442.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075063"/>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000047">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="144" mass="16642" checksum="3447AC32BA7D467D" modified="2020-06-17" version="1">MEGREEEFGFDIRLYPYPKESQSGSQSPFPSSPTTNTLSNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAK7</accession>
    <name>A0A670JAK7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Doublecortin like kinase 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JAK7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021487.1">
        <property type="protein sequence ID" value="ENSPMRP00000020237.1"/>
        <property type="gene ID" value="ENSPMRG00000013167.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154895"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042461">
        <property type="term" value="P:photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17069">
        <property type="entry name" value="DCX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000001">
        <property type="entry name" value="serine/threonine-protein kinase DCLK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000002">
        <property type="entry name" value="serine/threonine-protein kinase DCLK2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23005:SF4">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23005">
        <property type="entry name" value="RETINITIS PIGMENTOSA 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Doublecortin" evidence="8">
        <location>
            <begin position="55"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="8">
        <location>
            <begin position="178"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="309" mass="34900" checksum="1BF8A09E30D3ECD6" modified="2020-06-17" version="1">MASPRRNLELEHFEERDKRHPRSRNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDKYFKGLVYPISSDRFRSFDALLAELTRSLSDNVNLPQGVRTIYTIDGSRETLQPRRAGESYVCASNEPFRKVDYTKNVNPNWSVNIKSVSSRSLTSLTSARSELKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFDQVLTDITEAIKLDSGVVKRICTLDGKQVTCLQDFFGDDDVFIACGPEKYRYAQDDFVLDHSASSAYESTEVKKVVSADDVEGSERKMRLVNLGKVANLGEGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC73</accession>
    <name>A0A670JC73_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">E3 ubiquitin/ISG15 ligase TRIM25-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114590592</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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        <property type="protein sequence ID" value="ENSPMRP00000021757.1"/>
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        <location>
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    <sequence length="1143" mass="133967" checksum="F911B3DF7591DA1A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFA1</accession>
    <name>A0A670JFA1_PODMU</name>
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        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MED1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028702147.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000023096.1"/>
        <property type="gene ID" value="ENSPMRG00000015000.1"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031100">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0033148">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060335">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0003406">
        <property type="term" value="P:retinal pigment epithelium development"/>
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        <property type="term" value="P:ventricular trabecula myocardium morphogenesis"/>
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    <feature type="domain" description="Mediator complex subunit Med1" evidence="11">
        <location>
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        <location>
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        <location>
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        <location>
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    <sequence length="1592" mass="169248" checksum="6F2005D09CED90BD" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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</entry>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <reaction evidence="1">
            <text>Hydrolysis of alpha-(2-&gt;3)-, alpha-(2-&gt;6)-, alpha-(2-&gt;8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:exo-alpha-sialidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Neuraminidase 4"/>
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    </dbReference>
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        <property type="entry name" value="Sialidases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="498"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="509" mass="56432" checksum="5B6C82A2162EEE72" modified="2020-06-17" version="1">HVKSHNAMGSRHFPARTVLFERETSGVTYRVPALLHIPCVAKLLAFAEERLSVDDAHANLLVLRRGTFYKNFVDWEDMRALETATLAHHRSMNPCPIYDELTGMVFLFFIAVLGRTPEAFQIITGQNAARLCYVTSSDQGISWSHVTDLTQQVIGVSIEDWATFALGPGHGIQLKSGRLLLPAYAYHIDCKECFGKLCKTTPHAFTFYSDDHGQSWQFGEFIPNLQTVECQMVSVDEEDGSNVLYCNARSPLGFRVQALSTDDGAVFHSGQLVQRLVETPHGCHGSIIGFQAPLYYLQHNTCVFQRDTCSDKDVGFLPQGWSDTKHPPSLASLTPFFCSQPLSHRQPQETRTSGVCSGPISSGKGHADLEHAEAGSISQSGFSFQMPTWVLYCHPTSSRSRVNLGIYLSTFPRDADSWTEPWVIYEGPSAYSDLAYIELPYPDLSITGIPAIAFACLYENGVRSPYEQISFSMFTLHEVLQNIPLTTSAPSLKQPSGGRKRKGKSCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JIC7</accession>
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        <recommendedName>
            <fullName evidence="4">S-phase kinase-associated protein 1</fullName>
        </recommendedName>
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    <gene>
        <name evidence="8" type="primary">LOC114604549</name>
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    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028600586.1">
        <property type="nucleotide sequence ID" value="XM_028744753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JIC7"/>
    <dbReference type="SMR" id="A0A670JIC7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019070.1">
        <property type="protein sequence ID" value="ENSPMRP00000017920.1"/>
        <property type="gene ID" value="ENSPMRG00000011819.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000026003.1">
        <property type="protein sequence ID" value="ENSPMRP00000024508.1"/>
        <property type="gene ID" value="ENSPMRG00000015828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604549"/>
    <dbReference type="KEGG" id="pmua:114604549"/>
    <dbReference type="GeneTree" id="ENSGT00390000012652"/>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000270">
        <property type="entry name" value="S-phase kinase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="7">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="6">
        <location>
            <begin position="113"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="163" mass="18658" checksum="C794D62AFB75528A" modified="2020-06-17" version="1">MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKS2</accession>
    <name>A0A670JKS2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JKS2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026059.1">
        <property type="protein sequence ID" value="ENSPMRP00000024560.1"/>
        <property type="gene ID" value="ENSPMRG00000015870.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000185058"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052685">
        <property type="entry name" value="Apoptosis_Repressor_CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22797">
        <property type="entry name" value="CARD6/NUCLEOLAR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22797:SF36">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="181" mass="20537" checksum="8F0C41621ECA6C69" modified="2020-06-17" version="1">SIPASEAPIYEIIRKGRKQLIDILQKDIDCVLDDLRSEIVITKEEYEGLEKIKDSKKKSRELLILIQEKGEAACSQFLECLEVACPASKHALQVQKHGESHYSSQILKTFRYIFLLPCYHNIHMSFSSPDLACCITANVQNVYPILLETSLFLGCSVGDEESKIQKHPEEEKIDLEISNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JN32</accession>
    <name>A0A670JN32_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YAE1 maturation factor of ABCE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YAE1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028605451.1">
        <property type="nucleotide sequence ID" value="XM_028749618.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028605452.1">
        <property type="nucleotide sequence ID" value="XM_028749619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JN32"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025862.1">
        <property type="protein sequence ID" value="ENSPMRP00000024377.1"/>
        <property type="gene ID" value="ENSPMRG00000015754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606972"/>
    <dbReference type="KEGG" id="pmua:114606972"/>
    <dbReference type="CTD" id="57002"/>
    <dbReference type="GeneTree" id="ENSGT00390000011176"/>
    <dbReference type="OMA" id="VKKQTVW"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="5">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="196" mass="21815" checksum="43BFA6910BA5F84C" modified="2020-06-17" version="1">MSWVQAAVSQHSEDVFDEDANEMDIAQKEWKSTMEKRVKEGYREGAEAGRLLTVQEGFNQGYKEAARKMISCGQLKGTISALSFWCQHNGCSSGVQSEVTDLLNELGKYEESVFRSLNSTHLQPHVEDLLDTIEDMDLGHALLPEKQHDGTTGGRISENGIEFSGQCCRNDSRTGSFQEECCRRRKGGTDSQKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQ06</accession>
    <name>A0A670JQ06_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">UFM1-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UBA5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605991.1">
        <property type="nucleotide sequence ID" value="XM_028750158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JQ06"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027109.1">
        <property type="protein sequence ID" value="ENSPMRP00000025539.1"/>
        <property type="gene ID" value="ENSPMRG00000016542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607199"/>
    <dbReference type="KEGG" id="pmua:114607199"/>
    <dbReference type="CTD" id="79876"/>
    <dbReference type="GeneTree" id="ENSGT00940000156177"/>
    <dbReference type="OMA" id="ACCKADQ"/>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030219">
        <property type="term" value="P:megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050905">
        <property type="term" value="P:neuromuscular process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033146">
        <property type="term" value="P:regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032649">
        <property type="term" value="P:regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000066">
        <property type="entry name" value="Putative ubiquitin-like modifier-activating enzyme 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="46"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="398" mass="44193" checksum="2624947029630B15" modified="2020-06-17" version="1">MAASEQLVEQLRRRVRELEEELGRGEGGRRARIEQMSPEVTDSNPYSRLMALKRMGIVKDYEKIRSFAVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVQAAEHTLRNINPDVQFEVHNYNITTVDNFQHFMDRISNGGLEEGKPIDLVLSCVDNFEARMAINTACNELGQIWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGLLVQNVLKYLLNFGTVSFYLGYNAMQDFFPSMTMKPNPQCDDRNCRHQQEEYKKKAAENPKVEVIEQEEEIVHEENDWGIELVSEVSEEELKAASGPVLDLPEGITMAYTIPNKVEENAVTGETVPESEESLEELMAKMKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQ69</accession>
    <name>A0A670JQ69_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Junctional adhesion molecule A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Junctional adhesion molecule 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">F11R</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="18">Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with ITGAL (via I-domain). Interacts with CD151.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the immunoglobulin superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028565641.1">
        <property type="nucleotide sequence ID" value="XM_028709808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JQ69"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028161.1">
        <property type="protein sequence ID" value="ENSPMRP00000026546.1"/>
        <property type="gene ID" value="ENSPMRG00000017163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586403"/>
    <dbReference type="CTD" id="50848"/>
    <dbReference type="GeneTree" id="ENSGT00940000159186"/>
    <dbReference type="OMA" id="VEWKFVH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090557">
        <property type="term" value="P:establishment of endothelial intestinal barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050892">
        <property type="term" value="P:intestinal absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007159">
        <property type="term" value="P:leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035683">
        <property type="term" value="P:memory T cell extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903142">
        <property type="term" value="P:positive regulation of establishment of endothelial barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901731">
        <property type="term" value="P:positive regulation of platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902396">
        <property type="term" value="P:protein localization to bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000810">
        <property type="term" value="P:regulation of bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090559">
        <property type="term" value="P:regulation of membrane permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000342">
        <property type="entry name" value="Junctional adhesion molecule A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042456">
        <property type="entry name" value="F11R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45113">
        <property type="entry name" value="JUNCTIONAL ADHESION MOLECULE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45113:SF1">
        <property type="entry name" value="JUNCTIONAL ADHESION MOLECULE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025466007" description="Junctional adhesion molecule A" evidence="20">
        <location>
            <begin position="25"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="128"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="312" mass="34897" checksum="7246C721EEE4E5A0" modified="2020-06-17" version="1">MAVAAMGWLWWGCFCAGLWSLISGQSSQETLVQVPENSEARLPCKAYQGSPRRVEWKFQGDGSTTLFYFDGHFTDPYKDRVQFYPNELFFKSVTRKDTGLYICEVLVPPEDFRHSSVRLIVQVPPSKPKAQVPSVVTIGTKAVLTCVETDGSPPPTFTWFKDNIPMPQDPKTNSLFRNSSYTMDPKTGLLSFEPAMAYDAGDYYCQADNKVGAPQKSDTVRMETSEVNVGGIVAGVVVLLIVLGLVIFGVWFAYTRGFFSTPPAIRRSFTANLLPEVMVNLNRRLPSWSDLHSHVAFHHVLKSNLSLLLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQQ2</accession>
    <name>A0A670JQQ2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3',5'-cyclic-AMP phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.53</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25278"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.53" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670JQQ2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028367.1">
        <property type="protein sequence ID" value="ENSPMRP00000026736.1"/>
        <property type="gene ID" value="ENSPMRG00000017284.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000178250"/>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040844">
        <property type="entry name" value="PDE4_UCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18100">
        <property type="entry name" value="PDE4_UCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0114">cAMP</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphodiesterase 4 upstream conserved regions (UCR)" evidence="7">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="139" mass="15691" checksum="D5584E0749FEB02A" modified="2020-06-17" version="1">MKEQHSCVGTGHPPMAGYGRMAPLELAGSPVKRLRTEYSFPYLFAEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKVGQKPPPRSHLLPQLVRKRAMIFLEEWCNINAMANLISLLTADLIYTGRGKREGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRG8</accession>
    <name>A0A670JRG8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase, Mg2+/Mn2+ dependent 1H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPM1H</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028603639.1">
        <property type="nucleotide sequence ID" value="XM_028747806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JRG8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027155.1">
        <property type="protein sequence ID" value="ENSPMRP00000025582.1"/>
        <property type="gene ID" value="ENSPMRG00000016572.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606039"/>
    <dbReference type="KEGG" id="pmua:114606039"/>
    <dbReference type="CTD" id="57460"/>
    <dbReference type="GeneTree" id="ENSGT00940000160095"/>
    <dbReference type="OMA" id="VMAGGSN"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF287">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="89"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="527" mass="57378" checksum="20D3A01A198C80C6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRQ9</accession>
    <name>A0A670JRQ9_PODMU</name>
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        <submittedName>
            <fullName evidence="5">CHD1 helical C-terminal domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CHCT1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JRQ9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027246.1">
        <property type="protein sequence ID" value="ENSPMRP00000025667.1"/>
        <property type="gene ID" value="ENSPMRG00000016628.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003769"/>
    <dbReference type="OMA" id="KAYCRLE"/>
    <dbReference type="OrthoDB" id="9388842at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039880">
        <property type="entry name" value="CHCT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21765:SF1">
        <property type="entry name" value="CHD1 HELICAL C-TERMINAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21765">
        <property type="entry name" value="SIMILAR TO CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1 (CHD-1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromodomain-helicase-DNA-binding protein 1-like C-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="264" mass="30291" checksum="99BD1811219D8656" modified="2020-06-17" version="1">MGEATAGRMAGLEEWRNKATELQLPTCRDHETSHRETLTRVAPSGDALVHYADGLTQDTFKICKEFLRPFKKCLRKLNLPKDFPKEKRLSCTRKNLTILGDHINMFLQHYCKTWELKHWKKMLWRFVSLFSALDEKQLCRLYRYSKTDQMAKFLKAYCRLESPDMVVLPDCGKLMKLRDTWGLQGGAKMQGKLKQVCSLSQDSDLPPGSTSKKRLHKRPSKARRKEGVDISHPTYMATISPTSTSNEAAKLSPAAEETPLKTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRR9</accession>
    <name>A0A670JRR9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Surfeit locus protein 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JRR9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029403.1">
        <property type="protein sequence ID" value="ENSPMRP00000027718.1"/>
        <property type="gene ID" value="ENSPMRG00000017884.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004339"/>
    <dbReference type="OMA" id="LLCEAYW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="183" mass="20951" checksum="680D1F9B4B793BC6" modified="2020-06-17" version="1">MSQQRVLPQSKETFLQSYNKRLKDDIKSVMDNFREIIKTAKIEEETQVSRATQGEQDNCEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSINEAINQQNQQLRSLQEECDKKLIALRDQISIDLYVLEEEYYSSSYSLCDTNKLLLCEAYWRQEPTTSSPEGLAMPLVAAMYGAGLTEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRX4</accession>
    <name>A0A670JRX4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Meiosis-specific with OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MEIOB</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of a multiprotein complex with RPA2 and SPATA22. Interacts with SPATA22. Interacts with the complex BRME1:HSF2BP:BRCA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the MEIOB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JRX4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029465.1">
        <property type="protein sequence ID" value="ENSPMRP00000027778.1"/>
        <property type="gene ID" value="ENSPMRG00000017924.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001723"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000239">
        <property type="entry name" value="Meiosis specific with OB domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000248">
        <property type="entry name" value="Meiosis specific with OB domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000171">
        <property type="entry name" value="meiosis-specific with OB domain-containing protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056880">
        <property type="entry name" value="OB_MEIOB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24903">
        <property type="entry name" value="OB_MEIOB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEIOB-like N-terminal" evidence="16">
        <location>
            <begin position="149"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="589" mass="66594" checksum="3F46061B23CD0296" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JV17</accession>
    <name>A0A670JV17_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="17">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PLCB3</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58433"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:43485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="19">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="17"/>
    <dbReference type="RefSeq" id="XP_028565032.1">
        <property type="nucleotide sequence ID" value="XM_028709199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JV17"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029431.1">
        <property type="protein sequence ID" value="ENSPMRP00000027745.1"/>
        <property type="gene ID" value="ENSPMRG00000017903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586167"/>
    <dbReference type="KEGG" id="pmua:114586167"/>
    <dbReference type="CTD" id="5331"/>
    <dbReference type="GeneTree" id="ENSGT00940000160539"/>
    <dbReference type="OMA" id="IWSEELF"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099524">
        <property type="term" value="C:postsynaptic cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007208">
        <property type="term" value="P:phospholipase C-activating serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003073">
        <property type="term" value="P:regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16210">
        <property type="entry name" value="EFh_PI-PLCbeta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000048">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1230.10:FF:000003">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.240:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF11">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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    </organism>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1103"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1135"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1418" mass="153420" checksum="4710DFD5BFAFA58D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVW6</accession>
    <name>A0A670JVW6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029216.1">
        <property type="protein sequence ID" value="ENSPMRP00000027549.1"/>
        <property type="gene ID" value="ENSPMRG00000017779.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166555"/>
    <dbReference type="OMA" id="LWGRHID"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="479"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="1027"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1256"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1287"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1347"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1370" mass="151150" checksum="C9BD97D435582A9B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0L3</accession>
    <name>A0A670K0L3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K0L3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030904.1">
        <property type="protein sequence ID" value="ENSPMRP00000029134.1"/>
        <property type="gene ID" value="ENSPMRG00000018832.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286944"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="99" mass="11592" checksum="14EA60E88325D7EA" modified="2020-06-17" version="1">MRPLTEALSTFHIQCLECGKSFIWKDNLTSHQRIHKSVTSHQRIHTGEKPYQCLECEKSFNQNTHLISHQRIHTGRETHIRSLTSHERIHTGVKPLKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0P0</accession>
    <name>A0A670K0P0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA replication fork stabilization factor DONSON</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DONSON</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DONSON family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K0P0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030943.1">
        <property type="protein sequence ID" value="ENSPMRP00000029174.1"/>
        <property type="gene ID" value="ENSPMRG00000018852.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000447"/>
    <dbReference type="OMA" id="WCLKTRV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030894">
        <property type="term" value="C:replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024861">
        <property type="entry name" value="Donson"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972">
        <property type="entry name" value="DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972:SF0">
        <property type="entry name" value="PROTEIN DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02064">
        <property type="entry name" value="DONSON"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="439" mass="49511" checksum="43BA320468F7144D" modified="2020-06-17" version="1">IWKEEFSEAVSDPYLAISNTDVSSSPSYEFPADWSIKTRLLFTSSQSFAWADHLKAQEESLGYVQHCRGALINLPQSIQEPKLSTELRCAFQQSLVYWLHPFLPWLKLFPRIGADRKMTGKNNPWSYDEGLQQVLMSEWCLSFTSLYNLLRAKLCPYFYVCTYQFTVLFRAAGLAGSDVITALISPTTRGLREAMRNEGIEFLLPFQEVRKRKSNVGVSLLRGRGMSDVDDDEGFSWLEEMGLQDKIKKPDTISIKLCKERNEVQMDHKPESVVLVKGTNTFTLLNFLINCKSLVAAAGPQAGIPPTLLSPVAFRGATMQTLKARSINVRTQVQSHYKDLFSLEIVGPVMPHSMHSLSMLLRSAQNGSYSAVCYTHDPTAVFNTSISNEQSIKEDPYSKDLKKCGLHPNTLEQLTLCPTLGKSSIRLLEMNNYAYTWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K551</accession>
    <name>A0A670K551_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inactive rhomboid protein</fullName>
            <shortName evidence="2">iRhom</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Rhomboid family member</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Rhomboid veinlet-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K551"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033873.1">
        <property type="protein sequence ID" value="ENSPMRP00000031941.1"/>
        <property type="gene ID" value="ENSPMRG00000020690.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156278"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022241">
        <property type="entry name" value="iRhom1_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF4">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12595">
        <property type="entry name" value="iRhom1-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inactive rhomboid protein 1/2 N-terminal" evidence="3">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="168" mass="18834" checksum="2B0B0A60B617A7AC" modified="2020-06-17" version="1">MPETSGSQQSCSQCLAPPPHRAFLRSVSMPTEHTRFPSPFGDLRRPVLQRHTSITQTIRRGTADWFGVSKESDATQKWQRKSLRHCSLRYGKLKPQVIREMDLPSQDNISLASAETPPPLYVPPCQLGMKSCLPWLVGGLAERPGGHQAPGRGREEEGHLEYCEQSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5P8</accession>
    <name>A0A670K5P8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C-type natriuretic peptide</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the natriuretic peptide family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K5P8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033465.1">
        <property type="protein sequence ID" value="ENSPMRP00000031550.1"/>
        <property type="gene ID" value="ENSPMRG00000020438.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006182">
        <property type="term" value="P:cGMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042311">
        <property type="term" value="P:vasodilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002406">
        <property type="entry name" value="C_natriurtcpep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000663">
        <property type="entry name" value="Natr_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030480">
        <property type="entry name" value="Natr_peptide_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12167">
        <property type="entry name" value="C-TYPE NATRIURETIC PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12167:SF2">
        <property type="entry name" value="C-TYPE NATRIURETIC PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00212">
        <property type="entry name" value="ANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00713">
        <property type="entry name" value="CNATPEPTIDE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00710">
        <property type="entry name" value="NATPEPTIDES"/>
    </dbReference>
    <dbReference type="SMART" id="SM00183">
        <property type="entry name" value="NAT_PEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00263">
        <property type="entry name" value="NATRIURETIC_PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0382">Hypotensive agent</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <keyword evidence="6 8" id="KW-0838">Vasoactive</keyword>
    <keyword evidence="2" id="KW-0840">Vasodilator</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="12750" checksum="94B6B7D661DD660C" modified="2020-06-17" version="1">MPPAQFAAPPVLPVPRTGDIPRGDSLGWQESPPVGVRKCVLMGAPFSPAPTQPPPPAIALPAALGNPRFLEGAQKGKGSSSSSRLMRDLRTDTKQSRHHKGSSKSCFGLKLDRIGTISGLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5S1</accession>
    <name>A0A670K5S1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIERCE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K5S1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032868.1">
        <property type="protein sequence ID" value="ENSPMRP00000030984.1"/>
        <property type="gene ID" value="ENSPMRG00000020078.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154745"/>
    <dbReference type="OMA" id="HQCRASS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026507">
        <property type="entry name" value="PIRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899">
        <property type="entry name" value="PIERCE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899:SF1">
        <property type="entry name" value="PIERCER OF MICROTUBULE WALL 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14892">
        <property type="entry name" value="PIRC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="133" mass="15265" checksum="14BA00C2AF61A4D0" modified="2025-10-08" version="2">MANQCPSISLEKKDGEVGQRTSDYYRVEPTLPRRFNNPGWFWGYRFKEPNPLFRTTNMDYGGKPPTVHEMPTSFHVSPHAFSNHLVKFGPYRNTGINTNTEKSYVTGAENFITCFDTLNFHPSYRTGGPSFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7E0</accession>
    <name>A0A670K7E0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K7E0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034659.1">
        <property type="protein sequence ID" value="ENSPMRP00000032686.1"/>
        <property type="gene ID" value="ENSPMRG00000021178.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000285052"/>
    <dbReference type="OMA" id="PSHWSSE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="533" mass="59829" checksum="AFB658B77FD74D19" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7T9</accession>
    <name>A0A670K7T9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7T9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034326.1">
        <property type="protein sequence ID" value="ENSPMRP00000032370.1"/>
        <property type="gene ID" value="ENSPMRG00000020963.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155138"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035821">
        <property type="term" value="P:modulation of process of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000039">
        <property type="entry name" value="Brain-specific serine protease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF144">
        <property type="entry name" value="CHYMOTRYPSIN-LIKE PROTEASE CTRL-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="87"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        <source>
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        <source>
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        <source>
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    <sequence length="353" mass="37268" checksum="6AF1F9EC55DBED61" modified="2020-06-17" version="1">MSAWRGGRSALGRPARRAAGCYPQRGKPCWDLRQGSPRCGCLPGEGGALLYGAPPAGRQAAIRSVGSLAGTSGKAPHAADSVISPRIVGGNPAPEGAWPWQVSFMENNKPICGGSLINEKWVVSAAHCFTKQLNLPTTQYDVLLGAYQLSIPPSSLVVTTVQQVISHPNYNNIDGSPGDIALVELKAPLDLNDYILPVCLPDSSAQFSMDTSCWVTGWGQVKDGEALPPPQTLQELEVPLIDQDTCNSLFNSAPAPDLPQNPVLDDMICAGYPEGGKDACHGDSGGPLVCRCDAGWTLAGVVSWGEGCAEPKHPGVYTLVPYYANWISDNVPNISFVACNHAGWHSSKGIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8Y8</accession>
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    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23450"/>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="2093" mass="225553" checksum="375FDD74EA159719" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        </subcellularLocation>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="463" mass="50828" checksum="CD1A16704CF74154" modified="2020-06-17" version="1">MMATQTLSIDNYQDGQQQMQVVTELKTEQDPNCLEADAGGLSPSPVESQTPMDADKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGESGSPYSPVQPQSSNFKHDRDSLDLLEQLSSWKESPENPIQSAITGTLSPQGIMVPASALQQGNVTMATVAGGTVYQPVTVVTPQGQVVTQALSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQHQSNELTMSDGAVVTITAPVNMNVDSLQSLSSDGTTLAVQQVMMAGQSEDESVDSTEDDGADLSTTNISGLVLDNSDSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9W4</accession>
    <name>A0A670K9W4_PODMU</name>
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        <submittedName>
            <fullName evidence="8">Erythrocyte membrane protein band 4.1 like 1</fullName>
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        <name evidence="8" type="primary">EPB41L1</name>
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    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        </subcellularLocation>
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        <property type="protein sequence ID" value="ENSPMRP00000032379.1"/>
        <property type="gene ID" value="ENSPMRG00000020983.1"/>
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    <dbReference type="OMA" id="EPPHDKG"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:structural molecule activity"/>
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        <property type="project" value="InterPro"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598959.1">
        <property type="nucleotide sequence ID" value="XM_028743126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KAR3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035491.1">
        <property type="protein sequence ID" value="ENSPMRP00000033455.1"/>
        <property type="gene ID" value="ENSPMRG00000021686.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603828"/>
    <dbReference type="KEGG" id="pmua:114603828"/>
    <dbReference type="CTD" id="7247"/>
    <dbReference type="GeneTree" id="ENSGT00940000153568"/>
    <dbReference type="OMA" id="DAFHFTI"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902555">
        <property type="term" value="C:endoribonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.190:FF:000001">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="229" mass="26032" checksum="978F2E8FDFD65176" modified="2020-06-17" version="1">MSVSEMFIALQGVLTADQDIREEIRKVVQTLEQTAREILTVLQGVHQGSGFQDIPKKCQKAREHFGTVRTQLASLKNKFPADQYYRFNEHWRFVLQRLVFLAAFVVYLETETLVTREAATEILGIESEREKGFHLDIEDYLSGVLTLASELARLAVNSVTAGDYARPLRISAFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKIEEVVYDLSIRGLNKDSIANAGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCJ4</accession>
    <name>A0A670KCJ4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basonuclin zinc finger protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNC2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KCJ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036156.1">
        <property type="protein sequence ID" value="ENSPMRP00000034090.1"/>
        <property type="gene ID" value="ENSPMRG00000022111.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005844"/>
    <dbReference type="OMA" id="HQEITMD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003416">
        <property type="term" value="P:endochondral bone growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060485">
        <property type="term" value="P:mesenchyme development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043586">
        <property type="term" value="P:tongue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040436">
        <property type="entry name" value="Disconnected-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021">
        <property type="entry name" value="DISCONNECTED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN BASONUCLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="755"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="957"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="890"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113759" checksum="18EE5E2220D5963F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCT3</accession>
    <name>A0A670KCT3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GRB2 related adaptor protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GRAP2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KCT3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035430.1">
        <property type="protein sequence ID" value="ENSPMRP00000033399.1"/>
        <property type="gene ID" value="ENSPMRG00000021650.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157307"/>
    <dbReference type="OMA" id="DEHDWEL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09941">
        <property type="entry name" value="SH2_Grb2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
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    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="55"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="209" mass="24670" checksum="B02F67B18C59ED61" modified="2020-06-17" version="1">MEATAKFDFNATGEDELSFRAGDVLKVSEEWYKAELNGYEGYVPKNFIDFHSPSWFHEDVSRHKAENMLRGNKVGSFIVRGTQNRPGDFSISVRYLCFVNVQHFKVMRDPKGNYFLWSEKFLSLNKLVEFYKTSSISRHAQIFLRDETQKEQPSNVVKFMKFDDEHDWELPLWDGLPKNKGLQWNRRWGLWWNYGKSIHAGSLKGYTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KD84</accession>
    <name>A0A670KD84_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GRHPR</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028567340.1">
        <property type="nucleotide sequence ID" value="XM_028711507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KD84"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034756.1">
        <property type="protein sequence ID" value="ENSPMRP00000032777.1"/>
        <property type="gene ID" value="ENSPMRG00000021241.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587374"/>
    <dbReference type="CTD" id="9380"/>
    <dbReference type="GeneTree" id="ENSGT00940000158578"/>
    <dbReference type="OMA" id="PHIAWAY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF137">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="74"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="179"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="391" mass="41872" checksum="35263C9379795E9F" modified="2020-06-17" version="1">MSNWNTRQHLGEASRPRALDVAADGHQGALPNKPLSAGRRPGQGLRGGEGAASPGVAFATRRMRAAAVQRLMKVFVTRRIPPEGLAALSRAGDVQQWDSDEPIPQSELLAGVAGKDGLLCLLSDRIDKEVLDAAGPSLKVISTLSVGYDHLAIEEIKKRGIRVGYTPDILTDATAELTVALLLATSRRLPESVEEVKNGGWTTWKPLWMCGYGLSNSTVGIIGLGRIGQAVAHRLKPFGVKKFLYAGRHPKPEAAVELKAEFVPLAKLAEESDFVIVTCSLTPDTQGMCNRDFFCKMKKTSVFINTSRGTVVNQKDLYEALVNGHIAAAGLDVTTPEPLPTDNPLLSLKNCVILPHIGSATYATRNAMSVLAANNLLAGLKGESMPSELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEF0</accession>
    <name>A0A670KEF0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tetratricopeptide repeat protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TTC28</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KIA0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036564.1">
        <property type="protein sequence ID" value="ENSPMRP00000034467.1"/>
        <property type="gene ID" value="ENSPMRG00000022370.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004581"/>
    <dbReference type="OMA" id="NMGPSTH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF67">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025592644" description="CUB domain-containing protein" evidence="5">
        <location>
            <begin position="39"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="48"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="326" mass="35342" checksum="7EE4CC0410924F82" modified="2020-06-17" version="1">MQGLPKETKMSKPAHRGGLQAWGKWLLLLNAAVPAVSPMQTVSVVDFCGQTLHGDGMVLTSHRDSRRYYFVVASTDCQLTMQAATPKDKVQFQFRFFLVYSMVRSPSSTLASNDHPTLALPKSRSERETPDPCTAGSYVQFYDGQNHTAKPLGMPLCGKNIPRPVTSTGNFLTLRLVTRGQQPRVDFVGDFTSVRTGLNASACSMESYFPCHNGKCIPPSLVCDGSSVDNCGDGTDQAAQSPAWCKGSPTLLPPLNNAEASSAVNALPSQVTCAGPQESQLLPPGTATWDKTDKRKPLFASLAAILGAAFVFWCCWNPGWFIWRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KID1</accession>
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        <submittedName>
            <fullName evidence="4">Huntingtin interacting protein K</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">HYPK</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028562003.1">
        <property type="nucleotide sequence ID" value="XM_028706170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KID1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037539.1">
        <property type="protein sequence ID" value="ENSPMRP00000035409.1"/>
        <property type="gene ID" value="ENSPMRG00000022911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584365"/>
    <dbReference type="KEGG" id="pmua:114584365"/>
    <dbReference type="CTD" id="25764"/>
    <dbReference type="GeneTree" id="ENSGT00390000008502"/>
    <dbReference type="OMA" id="IIGDRRN"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="108"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="125" mass="13893" checksum="8FAC61DB33F72852" modified="2020-06-17" version="1">MAAEGDVELELEAEPNGSAGSGERPAEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMNEMEISRAAAERSLREHMGNVVEALITLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKN4</accession>
    <name>A0A670KKN4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RNA binding motif protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RBM10</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028567794.1">
        <property type="nucleotide sequence ID" value="XM_028711961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KKN4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039081.1">
        <property type="protein sequence ID" value="ENSPMRP00000036905.1"/>
        <property type="gene ID" value="ENSPMRG00000023777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587563"/>
    <dbReference type="CTD" id="8241"/>
    <dbReference type="GeneTree" id="ENSGT00940000160369"/>
    <dbReference type="OMA" id="CESEHER"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16167">
        <property type="entry name" value="OCRE_RBM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12753">
        <property type="entry name" value="RRM1_RBM10"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd12754">
        <property type="entry name" value="RRM2_RBM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000110">
        <property type="entry name" value="RNA-binding protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000114">
        <property type="entry name" value="RNA-binding protein 10 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="4.10.1060.10:FF:000005">
        <property type="entry name" value="RNA-binding protein 10 isoform X2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035618">
        <property type="entry name" value="RBM10_OCRE"/>
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    <dbReference type="InterPro" id="IPR034992">
        <property type="entry name" value="RBM10_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="287"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="777"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="13">
        <location>
            <begin position="875"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="632"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="733"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="947" mass="104828" checksum="036CE6E2693B1B34" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMI8</accession>
    <name>A0A670HMI8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HMI8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001151.1">
        <property type="protein sequence ID" value="ENSPMRP00000001089.1"/>
        <property type="gene ID" value="ENSPMRG00000000797.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="AFACENC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000540">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000466">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002291">
        <property type="entry name" value="Zinc finger protein 648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="397" mass="44672" checksum="F5DEE8CA354CB584" modified="2020-06-17" version="1">SETTINPESSSSTGDWEQLPGAYNTGLKGSTLAQSMFPSTIQSVAGDDQDNNGSRGSSERNKHEVKRTNDSPSCGKTFKGQESYQFHSREKPHRCSECGKSFSCRRNLTEHQKLHTGEKPYTCLDCGKTFRHSSSLASHQKTHTGEKAYKCLECEMSFTHSSSLISHQRIHTGEKSYKCSECGRSFAHSASLTSHKRTHTGDKPYKCLECGKNFSQSSHLSSHKRTHTGEKPYKCFECGKSFSQSSHLTVHERIHTGEKPYKCVTCGKSFSTCTYLVCHRRIHTGEKPYKCFECGKSFSQVTSLHIHQKIHRGEKPYACFECGKSFTQSSSLKYHQRIHTGEKPYSCFECGKNFSHSTSLTSHQRTHTGEKPYKCLECGKRFAHGSTLTSHKRTHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMT4</accession>
    <name>A0A670HMT4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HMT4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000308.1">
        <property type="protein sequence ID" value="ENSPMRP00000000292.1"/>
        <property type="gene ID" value="ENSPMRG00000000202.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048988"/>
    <dbReference type="OMA" id="EANHTYT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31450">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 19 LRRC19 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31450:SF3">
        <property type="entry name" value="TYPE III ENDOSOME MEMBRANE PROTEIN TEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="118" mass="13120" checksum="43FC0101035ED5E9" modified="2020-06-17" version="1">KPQINPTLKEPNLYESFLSFAASTTTLPPGKVAHSWPYFAAFVLSAIAISIVIALVAKCKLLQRNRASYNHQRLPDSRSIGTGCPAEDDDGFIEDNYIEPNQGFTNFSYSPIPYHPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HN33</accession>
    <name>A0A670HN33_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HN33"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000410.1">
        <property type="protein sequence ID" value="ENSPMRP00000000387.1"/>
        <property type="gene ID" value="ENSPMRG00000000296.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="367" mass="40308" checksum="57E310292833F587" modified="2020-06-17" version="1">MLVASRTLSHHLVLCRPLLLVPSIFPNIRVFSRESSLLMRWPKYWSPSFRICPSSEHSGRISFRMDQFDLLAVHGTLKSLLQHHNSKASILRRSAFFMVHLSLPYITVALTIRTFVGKVVSLLFKILSRFVIVFLPRSNTYMCVCVCVCVCVYACAYVCMCINMCACIYIFVCVHVHLDVCSYMCLCIQYIYVRSRISASRPRPHHVVRFLPPGPSSPRPPLAFRCCVAGARAGRGGGGVCHVGAWRAAGGWLARAQGRLRRRSLLLLRRGDRWESGFFPGLPAAAAEGAAAGAAWWRARRQRRRRRRDNEATLLLLASPRPSIAGLGPSPGGGGGGCSPARPWGTPSPAASLPAPAPSSAGSAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNE3</accession>
    <name>A0A670HNE3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ArfGAP with GTPase domain, ankyrin repeat and PH domain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AGAP2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HNE3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001098.1">
        <property type="protein sequence ID" value="ENSPMRP00000001036.1"/>
        <property type="gene ID" value="ENSPMRG00000000765.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158956"/>
    <dbReference type="OMA" id="CPNEPTP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904019">
        <property type="term" value="P:epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904036">
        <property type="term" value="P:negative regulation of epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08836">
        <property type="entry name" value="ArfGap_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04103">
        <property type="entry name" value="Centaurin_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01250">
        <property type="entry name" value="PH_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000001">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000211">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000459">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000545">
        <property type="entry name" value="arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF3">
        <property type="entry name" value="ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="332"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="11">
        <location>
            <begin position="568"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="448"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="808" mass="88579" checksum="6685397CF2E7CF19" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQL7</accession>
    <name>A0A670HQL7_PODMU</name>
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        <recommendedName>
            <fullName evidence="8">Maestro heat like repeat family member 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HQL7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002219.1">
        <property type="protein sequence ID" value="ENSPMRP00000002084.1"/>
        <property type="gene ID" value="ENSPMRG00000001531.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162865"/>
    <dbReference type="OMA" id="ENTEICY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF22">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
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    </dbReference>
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        <property type="entry name" value="HEAT_Maestro_2"/>
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    </dbReference>
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        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025652838" description="Maestro heat like repeat family member 1" evidence="2">
        <location>
            <begin position="18"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="4">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="3">
        <location>
            <begin position="173"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="5">
        <location>
            <begin position="594"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="93182" checksum="46AA9DE050A647FD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRZ7</accession>
    <name>A0A670HRZ7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HRZ7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002631.1">
        <property type="protein sequence ID" value="ENSPMRP00000002473.1"/>
        <property type="gene ID" value="ENSPMRG00000001786.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="HERTHDP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000706">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000953">
        <property type="entry name" value="Zinc finger protein 691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002431">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF331">
        <property type="entry name" value="ZINC FINGER PROTEIN 322A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002473.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="400" mass="45507" checksum="7F70A83B1BD7B9E8" modified="2020-06-17" version="1">MYYQKPKGSIGCQGFSRSSDPVRHQITHTGEKPYTCAVCGKGFSQNSNLLTHQRIHTGEKPYQCRDCSKRFSESSALIQHQRTHTGEKPYTCVECGKRFSVSSNLIRHRRTHTDERPYICEECREGFQHKSQLRRHQKLHVTIQSSIQHGQSNWKANSQQEGPAVDRQGSPLAPDSYGEGEGAVAAAVVSRSTKQRPFICNECGKSFSHWSKLLRHQRTHTGERPSTCTDCGKSFSQNSHLVQHRRTHTGEKPYVCRDCGKSFSWSSNLIQHQRIHTGERPYTCGDCGRSFTQSKNLAKHRRTHTGARPFRCPECGRGFAHTAGLVKHQRLRHDTDSPIGHPCPECGQRFRAPSEVERHRVAHHGVAPSEPFICVECGECFTKRTTLIRHKRVHKPIFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HS72</accession>
    <name>A0A670HS72_PODMU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002070.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="71" mass="8008" checksum="EA2DB794753A8D12" modified="2020-06-17" version="1">MLSLWVNQAFGTTVRCVCGRKYKTRAACVCWEARRQEESSPVCFCSSSRHHICGIVVWGMPISAVLQKCQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="4">Protein LBH</fullName>
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    <gene>
        <name evidence="10" type="primary">LBH</name>
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    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </comment>
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        <text evidence="3">Belongs to the LBH family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPMRP00000002801.1"/>
        <property type="gene ID" value="ENSPMRG00000002024.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN LBH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="178"/>
        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="180" mass="19863" checksum="331679ABBF3C2639" modified="2020-06-17" version="1">MILLTSSERVGGPCGPRHASLVYKRSCPLSLRESVLQRKSSVVSSCARGLPALLSCSYPLPCPSGRFPLGANRLVWPLFLSEASPFLLSGSAPLCSDTKDVGSASLLRLHVCIFPHSLIFPDPSDYDRYCKLKDRLPSIVVEPTEGDVESGELRWPPEEFLVQEQEEENCDEAKKESKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTM5</accession>
    <name>A0A670HTM5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin filament-associated protein 1-like 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AFAP1L2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HTM5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003314.1">
        <property type="protein sequence ID" value="ENSPMRP00000003089.1"/>
        <property type="gene ID" value="ENSPMRG00000002192.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183067"/>
    <dbReference type="OMA" id="FPPNCPD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030296">
        <property type="term" value="F:protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
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            <end position="297"/>
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    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="379"/>
            <end position="473"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="190"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="845" mass="95121" checksum="CB3DC81271ECA8E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HU67</accession>
    <name>A0A670HU67_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delayed-rectifier potassium channel regulatory subunit KCNS3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Delayed-rectifier potassium channel subunit Kv9.3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Potassium voltage-gated channel subfamily S member 3</fullName>
        </alternativeName>
    </protein>
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        <name evidence="21" type="primary">KCNS3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Potassium channel regulatory subunit that modulates the delayed rectifier potassium channel activity of KCNB1 by namely slowing down the deactivation and inactivation time constants. While it does not form functional channel on its own, it can form functional heterotetrameric channels with KCNB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterotetramer with KCNB1. Does not form homomultimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028722294.1"/>
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        <property type="nucleotide sequence ID" value="XM_028722295.1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:voltage-gated potassium channel complex"/>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY S MEMBER 3"/>
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    </dbReference>
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        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
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        <property type="entry name" value="KV9CHANNEL"/>
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        <property type="entry name" value="KVCHANNEL"/>
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    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="20">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082875"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="502" mass="57491" checksum="107BD63FE3339264" modified="2020-06-17" version="1">MVYGEFFHRPGQDEELVNLNVGGFKQSIGQSTLLRFPHTRLGKLLKCHSEEAILELCDDYSVAEKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFLDSCCSNRYQERKEEGLDKEWDQKSNAGSLDSSDDESSIFEKELEKFDKQWLGELRKNIWVRMENPASCLSAKLIAVSSLSVVLASIVTMCIHSMPEFQKLDANEREIEDPILEIVEIICIIWFTSELMIRLAAAPSQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLAVGISIFSVLVYSVEKDDDTSELQSIPICWWWATISMTTVGYGDTYPVTLGGKIIGTTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCNNDPKEKTNELPYFNIRDIYAKRMHSFISSLSSVGFVANDQDSTDASSIQDLDDVYNTTSLQNERASLVSSKTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUJ8</accession>
    <name>A0A670HUJ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670HUJ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003647.1">
        <property type="protein sequence ID" value="ENSPMRP00000003404.1"/>
        <property type="gene ID" value="ENSPMRG00000002398.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="GACHILF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="401"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="856" mass="99215" checksum="C9FE9EF83CF895AD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUN2</accession>
    <name>A0A670HUN2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ras-related protein Rab-17</fullName>
            <ecNumber evidence="6">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RAB17</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Recycling endosome membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028559275.1">
        <property type="nucleotide sequence ID" value="XM_028703442.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559283.1">
        <property type="nucleotide sequence ID" value="XM_028703450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HUN2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002994.1">
        <property type="protein sequence ID" value="ENSPMRP00000002792.1"/>
        <property type="gene ID" value="ENSPMRG00000002014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582421"/>
    <dbReference type="KEGG" id="pmua:114582421"/>
    <dbReference type="CTD" id="64284"/>
    <dbReference type="GeneTree" id="ENSGT00940000161839"/>
    <dbReference type="OMA" id="SCCKVGP"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098937">
        <property type="term" value="P:anterograde dendritic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002415">
        <property type="term" value="P:immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032402">
        <property type="term" value="P:melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050773">
        <property type="term" value="P:regulation of dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051963">
        <property type="term" value="P:regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001282">
        <property type="entry name" value="RAB17, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="223" mass="25729" checksum="F1C38CBB20DF1913" modified="2020-06-17" version="1">MAQRRVQNKEATPYLYVPCLKDSYIFKVVLLGSTAVGKSSLAYRYVKKDFRDSLPTVGCSFFTQVLSLDNTTIKLEIWDTAGQEKYHSVCHLYYRAANAAVLVYDITRKESLEKAKVWLAELEKEFLPDEIIIALVGNKLDLSAEREVTLQEAKDFAQTKNLQYMETSAKSNYQVTELFVSLAHELLKQEQQREKTFQSTQWKRSRVDLRETSFPQTKCCQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXE1</accession>
    <name>A0A670HXE1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HXE1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004689.1">
        <property type="protein sequence ID" value="ENSPMRP00000004394.1"/>
        <property type="gene ID" value="ENSPMRG00000003002.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="300" mass="34829" checksum="2B7FFBC933DEC595" modified="2020-06-17" version="1">MGVGQSFENGIGAIYSKQKAKLIVNNVVTEEIPIEKGTRQGCPLSPLLFITVLEVLLNMIRGDQLIKGVQHGAKDYKLRAFADDLVLTLQEPETSTKRVLELIEKFGQVAGFKLNMQKTKVLEKNLTMAEKEKFQSETGLTITKKVKYLGVNLTSRNVNLFKDNYEKCWTEVKKDLEIWSRLRLSLLGRIAVIKMNVLPRMLFLFQTLQILDKMDCFKRWQKDISKFVWQGKKPRIKFKILTDAKDRGGFALPDLRLYYESAAFCWLKQWLLLENTDILDLEVHVITRRRVFFVVVVFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXS4</accession>
    <name>A0A670HXS4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family with sequence similarity 124 member A</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM124 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HXS4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004681.1">
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    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00590000083134"/>
    <dbReference type="OMA" id="DARDITH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029380">
        <property type="entry name" value="FAM124"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046365">
        <property type="entry name" value="FAM124_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14715">
        <property type="entry name" value="FAM124 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14715:SF4">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15067">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM124" evidence="3">
        <location>
            <begin position="156"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="649" mass="71435" checksum="399F9D76FD72BA0F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZI2</accession>
    <name>A0A670HZI2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC22 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nucampholin homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CWC22</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028604103.1">
        <property type="nucleotide sequence ID" value="XM_028748270.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028604113.1">
        <property type="nucleotide sequence ID" value="XM_028748280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HZI2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004866.1">
        <property type="protein sequence ID" value="ENSPMRP00000004562.1"/>
        <property type="gene ID" value="ENSPMRG00000003124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606257"/>
    <dbReference type="KEGG" id="pmua:114606257"/>
    <dbReference type="CTD" id="57703"/>
    <dbReference type="GeneTree" id="ENSGT00940000153458"/>
    <dbReference type="OMA" id="ILTEDMR"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="886" mass="102670" checksum="B386F984FC4ACBE2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0C2</accession>
    <name>A0A670I0C2_PODMU</name>
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        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Episquamata</taxon>
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    </organism>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the splicing factor SR family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF63">
        <property type="entry name" value="SERINE AND ARGININE-RICH-SPLICING FACTOR 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 15" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="174"/>
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        </location>
    </feature>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="265" mass="30332" checksum="8B6849DF57DE3C5E" modified="2020-06-17" version="1">MSGCRVFVGRLSPHARERDVEKFFKGYGRIREINLKNGFGFVEFEDHRDADDAVYELNGKELCNERVTIEHARARRGGRGRYPQRFNYYQSYGGGSSQYGPPLRTEHRLIVENLSSRVSWQDLKDFMRKAGEVTFVDAHRNNPNEGVVEFASSSDMKSALDKLDGSELNGRRIKLIEDRKRRRSRSRSRSYSRSRSKSRSARSSKSTSKSRSRSRTPEKRGSRSRTPERKGSEKNHHSGPQNSSPSPPPAKKRSRSRSSSAESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1L7</accession>
    <name>A0A670I1L7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sushi repeat containing protein X-linked</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SRPX</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583237.1">
        <property type="nucleotide sequence ID" value="XM_028727404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I1L7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006111.1">
        <property type="protein sequence ID" value="ENSPMRP00000005746.1"/>
        <property type="gene ID" value="ENSPMRG00000003903.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000006120.1">
        <property type="protein sequence ID" value="ENSPMRP00000005755.1"/>
        <property type="gene ID" value="ENSPMRG00000003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596172"/>
    <dbReference type="CTD" id="8406"/>
    <dbReference type="GeneTree" id="ENSGT00940000160302"/>
    <dbReference type="OMA" id="RIQYTVY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060244">
        <property type="term" value="P:negative regulation of cell proliferation involved in contact inhibition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001845">
        <property type="term" value="P:phagolysosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001241">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000024">
        <property type="entry name" value="Sushi repeat-containing protein SRPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025232">
        <property type="entry name" value="DUF4174"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043555">
        <property type="entry name" value="SRPX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343">
        <property type="entry name" value="HYR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343:SF1">
        <property type="entry name" value="SUSHI REPEAT-CONTAINING PROTEIN SRPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13778">
        <property type="entry name" value="DUF4174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044625038" evidence="6">
        <location>
            <begin position="23"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="167"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="455" mass="50765" checksum="F275278EFEFB22F6" modified="2020-06-17" version="1">MRSPSVCLAALLLAVGARFSLAYQGSGYSPLEDDEDVYAHNRYKDTPWCSPIKVKYGYASCRSPRGGYYKNVLGTKCDIRCQKGYELHGPQELMCQSNKRWSGKVLCKQKRCPTLSMPGNGGFKCLDGAYYNSRCEYYCSPGYQLKGDRIVQCMDNKLWSGRPASCVDMEPPRIQCPSVKEKTAEPNKLTARVFWETPEGRDTADGILTDVILKGLPPGSHFSEGDHKIHYTVFDRAGNKGTCRFYVKVKVRRCGKLNAPENGYIKCSGDGDNYGATCEFSCIGGYELQGSPARVCQYNLGWSGTEPTCTPMNINVGVRTAAALLDQFYEKRRLLIISTPTAANYFYRLQLGMLQPALCGLDLRHVTVIELVGVYPAQLGRIGLRLMPPALALQLRLLLRIPHYNFNMVVVDKHGVDKERYPFPATPAELFALIDTFPLRKEEMKLQAEAGQSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1M7</accession>
    <name>A0A670I1M7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CDH4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I1M7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006124.1">
        <property type="protein sequence ID" value="ENSPMRP00000005759.1"/>
        <property type="gene ID" value="ENSPMRG00000003908.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158073"/>
    <dbReference type="OMA" id="QICERPG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045773">
        <property type="term" value="P:positive regulation of axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000019">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000022">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000027">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000045">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000001">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014868">
        <property type="entry name" value="Cadherin_pro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF81">
        <property type="entry name" value="CADHERIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08758">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01820">
        <property type="entry name" value="DESMOCOLLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01055">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="151"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="259"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="374"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="488"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="594"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="110"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I379</accession>
    <name>A0A670I379_PODMU</name>
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                <person name="Sabatino S.J."/>
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                <person name="Bosakova Z."/>
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                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="2">Belongs to the Caudal homeobox family.</text>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3G3</accession>
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        </submittedName>
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    </gene>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="component" value="Chromosome 7"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:acyltransferase activity"/>
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        <property type="project" value="InterPro"/>
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    <sequence length="318" mass="36641" checksum="DE09039F43E7CE23" modified="2020-06-17" version="1">MPMSYLTCLLYILEGWTGVEHLDEYLSYLVYLTWLFAPLLVAFLLPALILILVYVSIFILHIYKLRTHLKEVYSNDFWDGARLAVLTLWYVHGRIWNGYEVHGLEKIPDGPALFIFYHGATPIDFFYFVSVLLTKKKKFIHVVADHFVFSLPGFKIVVDVFRTLPGSQEECIKALKSGRSLAISPGGVREALFANEYYPILWGNRKGFAQVAIDAKVPIIPLFTQNVRESVRTFGGIKFLRWVYEKTRWPLVPLYGNFPVKLRTYIGDPIPYDPNVTAAELAEKAKNAIQCLIDKHQKIPGNVFRALMERFETQKKED</sequence>
</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <source>
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    </evidence>
    <sequence length="123" mass="14115" checksum="9FABFD3105486E68" modified="2020-06-17" version="1">MDPERLVQCPYDKNHQIRACRLPYHLVKCRKNNQKIARELATCPYNARHRVPKQELKLHIATCENKVSPEVLEVTSSRGDPKNRIKEVTAWQCPPPEEDWEADAAECPAPPFVFGTSYSGERS</sequence>
</entry>
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    <accession>A0A670I792</accession>
    <name>A0A670I792_PODMU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            </authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="2">Belongs to the polycystin family.</text>
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        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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    </dbReference>
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        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
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        <property type="entry name" value="PKD_2"/>
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        <property type="entry name" value="Polycystin"/>
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    </dbReference>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF47">
        <property type="entry name" value="POLYCYSTIN-2-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
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            <end position="250"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="16">
        <location>
            <begin position="225"/>
            <end position="449"/>
        </location>
    </feature>
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        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="541" mass="63325" checksum="30BCF2DFFC35A217" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8E9</accession>
    <name>A0A670I8E9_PODMU</name>
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        <submittedName>
            <fullName evidence="14">Krueppel-like factor 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114599313</name>
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    <organism evidence="14 15">
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        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="gene ID" value="ENSPMRG00000005363.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000156977"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 15"/>
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    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="333"/>
            <end position="360"/>
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        <location>
            <begin position="127"/>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    <sequence length="372" mass="40056" checksum="A8933A64A68DB0DB" modified="2020-06-17" version="1">MVSVNHSKLVSASSQLTASAPIQLANASVALKHEMPPLNLLQDCSGEQASNPSATSNLICTSETGVSQSKVKKDGEKPQTTIYEAYLRLPDFCPELSRDFSPTLEEIEEFLNEKMAILKDELNDQQQAGGQLKRKSEISLGSPGEQSVPVAVPDEGLSSSAQSGVVVSGGTGIPGTVGAVPVVLQIQPNQASEGNSPTQSPVGGIRVAQLVIKMQGQSLTVLPQVIQSPSTGTEQKYVRIAPLPVTLRPGVLGSVKNVEARAPKASPPVIRVHKCTHPGCTKMYTKSSHLKAHFRRHTGEKPYTCTWPNCGWRFSRSDELSRHKRSHSGLKPYQCQVCEKKFARSDHLSKHMKIHKGSFSLGIRTAQGCGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9J5</accession>
    <name>A0A670I9J5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate synthase</fullName>
            <ecNumber evidence="3">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TYMS</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12105"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028593070.1">
        <property type="nucleotide sequence ID" value="XM_028737237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I9J5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009115.1">
        <property type="protein sequence ID" value="ENSPMRP00000008525.1"/>
        <property type="gene ID" value="ENSPMRG00000005762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600705"/>
    <dbReference type="KEGG" id="pmua:114600705"/>
    <dbReference type="CTD" id="7298"/>
    <dbReference type="GeneTree" id="ENSGT00390000014786"/>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="thymidylate synthase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="12">
        <location>
            <begin position="28"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="309" mass="35087" checksum="B65274B0E91EB4CE" modified="2020-06-17" version="1">MPAVVTETEGPREESSGAAAPPPHGELQYLRQVEQILRFGHRKEDRTGTGTFSVFGLQARYSLRDNFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSAKGVKIWDANGSREFLDKQGFFSREEGDLGPVYGFQWRHFGAEYKDMHTDYTGQGVDQLQQVIDTIRNNPDNRRIIMCAWNPKDISSMALPPCHALCQFYVLNGELSCQLYQRSGDMGLGVPFNIASYSLLTSMVAHVTGLKPGEFIHTLGDAHIYLNHIEPLKIQLQRQPRPFPKLKILRNVENINDFNADDFELEGYDPHPAIKMEMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IAQ6</accession>
    <name>A0A670IAQ6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">XRCC3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028606577.1">
        <property type="nucleotide sequence ID" value="XM_028750744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IAQ6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009579.1">
        <property type="protein sequence ID" value="ENSPMRP00000008965.1"/>
        <property type="gene ID" value="ENSPMRG00000006030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607474"/>
    <dbReference type="KEGG" id="pmua:114607474"/>
    <dbReference type="CTD" id="7517"/>
    <dbReference type="GeneTree" id="ENSGT00930000151053"/>
    <dbReference type="OMA" id="WANQVTV"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090267">
        <property type="term" value="P:positive regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058766">
        <property type="entry name" value="HHH_XRCC3_RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26169">
        <property type="entry name" value="HHH_XRCC3_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="83"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="360" mass="39827" checksum="F0F42B6BB6C1BA87" modified="2020-06-17" version="1">MERKYSKFLFRSKAEEFNKFLLPAKIKSIQEIMNLSGADLQRLTNLSRTDVQYLLRAISGALRKNSVLTALQLFQDRNHNTSQHQKLSLGCPILDSLLQGGIPLAGITEIAGESSAGKTQIGLQLSLSVQYPYKYGGLESGAVYICTEDVFPNKRLQQLIEQQPKARANISPDVVQKIKFGSGIFVEHAADLETFHECITKRINLLVSRGMVRLVVIDSIAALFRCEFAAKDSILKAKYLQIFGAKLHKLSSKFRVPVVCINQVTDTMDEKGGAAQSSPGCATKRVVPALGITWSNQLLMRLMASRRTDQPLAANDTPHQGRSALRTLRVVFAPHLPPSFCYYAVNLEGVKGIKETPPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICP0</accession>
    <name>A0A670ICP0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670ICP0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010042.1">
        <property type="protein sequence ID" value="ENSPMRP00000009414.1"/>
        <property type="gene ID" value="ENSPMRG00000006317.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000213429"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000859">
        <property type="entry name" value="myc-associated zinc finger protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="63" mass="6732" checksum="888DA2185286DBE0" modified="2020-06-17" version="1">AAPHSLPPPFPIPPLADKGPYICSLCAKEFKNGYNLRRHEAIHTGAKASRLVPSTIPLCPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICP4</accession>
    <name>A0A670ICP4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="15">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CDKAL1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 15">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum membrane</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="15"/>
    <dbReference type="RefSeq" id="XP_028593423.1">
        <property type="nucleotide sequence ID" value="XM_028737590.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593424.1">
        <property type="nucleotide sequence ID" value="XM_028737591.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593425.1">
        <property type="nucleotide sequence ID" value="XM_028737592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ICP4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010117.1">
        <property type="protein sequence ID" value="ENSPMRP00000009486.1"/>
        <property type="gene ID" value="ENSPMRG00000006355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600850"/>
    <dbReference type="KEGG" id="pmua:114600850"/>
    <dbReference type="CTD" id="54901"/>
    <dbReference type="GeneTree" id="ENSGT00940000155952"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="1730074at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000005">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="17">
        <location>
            <begin position="63"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="199"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="16">
        <location>
            <begin position="430"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="578" mass="65114" checksum="4362F7BAE2A5618A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICY2</accession>
    <name>A0A670ICY2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family with sequence similarity 184 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FAM184A</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028579112.1">
        <property type="nucleotide sequence ID" value="XM_028723279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ICY2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010098.1">
        <property type="protein sequence ID" value="ENSPMRP00000009467.1"/>
        <property type="gene ID" value="ENSPMRG00000006351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594093"/>
    <dbReference type="KEGG" id="pmua:114594093"/>
    <dbReference type="CTD" id="79632"/>
    <dbReference type="GeneTree" id="ENSGT00530000063669"/>
    <dbReference type="OMA" id="MCKKVAQ"/>
    <dbReference type="OrthoDB" id="75801at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039478">
        <property type="entry name" value="FAM184A/B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF7">
        <property type="entry name" value="PROTEIN FAM184A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15665">
        <property type="entry name" value="FAM184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein FAM184A/B N-terminal" evidence="4">
        <location>
            <begin position="58"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="209"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="306"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="646"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="719"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="977"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1157" mass="135536" checksum="835F7B246E504232" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEF4</accession>
    <name>A0A670IEF4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calbindin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CALB1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the calbindin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IEF4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010800.1">
        <property type="protein sequence ID" value="ENSPMRP00000010136.1"/>
        <property type="gene ID" value="ENSPMRG00000006764.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183108"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099567">
        <property type="term" value="F:calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099534">
        <property type="term" value="F:calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005499">
        <property type="term" value="F:vitamin D binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007616">
        <property type="term" value="P:long-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072205">
        <property type="term" value="P:metanephric collecting duct development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072286">
        <property type="term" value="P:metanephric connecting tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072221">
        <property type="term" value="P:metanephric distal convoluted tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035502">
        <property type="term" value="P:metanephric part of ureteric bud development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900271">
        <property type="term" value="P:regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007614">
        <property type="term" value="P:short-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000054">
        <property type="entry name" value="Calbindin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF14">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0848">Vitamin D</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="263" mass="30342" checksum="73239F2B41BE6099" modified="2020-06-17" version="1">MAAETYLQGVEISASQFFEIWRHYDADGNGYMDGKELQCFIQELQQARKKAGLDLTPEMKKFVDQFSSSDGKIGIVELAQILPTEENFLLFFRCQQLKSSEDFMQTWRKYDSDHSGYIDAEELKSFLKDLLQKANKQIEDTKLSEYTDIMLKMFDENNDGKLELTEMARLLPVQENFLLKFQGVKMCGKEFNKAFDTFDSDGNGYIDEQELDALLKDLCEKNKTVILILFPLKVHLNSALPHLVSYGSCSEFNIFQFLDTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IFB2</accession>
    <name>A0A670IFB2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitogen-activated protein kinase kinase kinase 19</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SPS1/STE20-related protein kinase YSK4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MAP3K19</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028600500.1">
        <property type="nucleotide sequence ID" value="XM_028744667.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028600509.1">
        <property type="nucleotide sequence ID" value="XM_028744676.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028600518.1">
        <property type="nucleotide sequence ID" value="XM_028744685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IFB2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010785.1">
        <property type="protein sequence ID" value="ENSPMRP00000010122.1"/>
        <property type="gene ID" value="ENSPMRG00000006759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604509"/>
    <dbReference type="CTD" id="80122"/>
    <dbReference type="GeneTree" id="ENSGT00940000160383"/>
    <dbReference type="OMA" id="RNMCSFQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000331">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="821"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120171" checksum="28612057FEA7B8E4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670III1</accession>
    <name>A0A670III1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670III1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011914.1">
        <property type="protein sequence ID" value="ENSPMRP00000011152.1"/>
        <property type="gene ID" value="ENSPMRG00000007445.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159931"/>
    <dbReference type="OMA" id="WERGREC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF24">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="212" mass="24556" checksum="9EF8ADC3D0C09631" modified="2020-06-17" version="1">MRTGAPLQFWVTTELCLCPDVIKRAQLLRKFIKLAAHLKDQKNLNSFFAVMFGLSHSTISRLSRTWEKLPHKTRKLFGTMERMLDPSWNHRVYRLAMAKLTPPLIPFMPLLLKDLTFIHEGNCTLVENLVNFEKLVNFFLTLLLFFPTPVPLSPLRSRPQHLLEEARALRASTCSEQSLSTRSPAATWAYTQHLRVIDSQKELLRLSRDLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKN7</accession>
    <name>A0A670IKN7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit 6B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">26S proteasome AAA-ATPase subunit RPT3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Proteasome 26S subunit ATPase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PSMC4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC4 and few additional components. Interacts with NR1I3. Interacts with PAAF1. Interacts with TRIM5. Interacts with ZFAND1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598444.1">
        <property type="nucleotide sequence ID" value="XM_028742611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IKN7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012969.1">
        <property type="protein sequence ID" value="ENSPMRP00000012149.1"/>
        <property type="gene ID" value="ENSPMRG00000008125.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603538"/>
    <dbReference type="KEGG" id="pmua:114603538"/>
    <dbReference type="CTD" id="5704"/>
    <dbReference type="GeneTree" id="ENSGT01020000230346"/>
    <dbReference type="OMA" id="QDIGGMD"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="198"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="418" mass="47410" checksum="C44A445F5012A256" modified="2020-06-17" version="1">MEEIGILVEKTQDELPALSISRPQTGLSFLVPEAEDVEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFTTITSKMNLSEEVDLEDYVARPDKISGADINSICQEAGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKW5</accession>
    <name>A0A670IKW5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MGAT5B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670IKW5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013044.1">
        <property type="protein sequence ID" value="ENSPMRP00000012217.1"/>
        <property type="gene ID" value="ENSPMRG00000008173.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000013056.1">
        <property type="protein sequence ID" value="ENSPMRP00000012229.1"/>
        <property type="gene ID" value="ENSPMRG00000008173.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153470"/>
    <dbReference type="OMA" id="SRFPECP"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF6">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="15">
        <location>
            <begin position="182"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="794" mass="90672" checksum="F8167F48CB7C8ECF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILB3</accession>
    <name>A0A670ILB3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein inturned</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Inturned planar cell polarity effector homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">INTU</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inturned family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ILB3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013650.1">
        <property type="protein sequence ID" value="ENSPMRP00000012780.1"/>
        <property type="gene ID" value="ENSPMRG00000008498.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001301"/>
    <dbReference type="OMA" id="CAGKSIS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="entry name" value="INTU"/>
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        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
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        <property type="entry name" value="PROTEIN INTURNED"/>
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        <property type="entry name" value="PROTEIN INTURNED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Intu_longin_1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILY6</accession>
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        <recommendedName>
            <fullName evidence="4">Serine/arginine repetitive matrix protein 1</fullName>
        </recommendedName>
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        <name evidence="7" type="primary">SRRM1</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the splicing factor SR family.</text>
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        <location>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00067280"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51025"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
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    <sequence length="904" mass="103361" checksum="8BA4C5E1EE05FEA9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IN74</accession>
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        <submittedName>
            <fullName evidence="13">Zic family member 1</fullName>
        </submittedName>
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        <name evidence="13" type="primary">ZIC1</name>
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    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IN74"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013971.1">
        <property type="protein sequence ID" value="ENSPMRP00000013091.1"/>
        <property type="gene ID" value="ENSPMRG00000008754.1"/>
    </dbReference>
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    <dbReference type="OMA" id="HICVWEE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:maintenance of cell number"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:olfactory bulb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008589">
        <property type="term" value="P:regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021510">
        <property type="term" value="P:spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000035">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000039">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000041">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001330">
        <property type="entry name" value="Zinc finger protein ZIC 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041643">
        <property type="entry name" value="Znf_ZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18366">
        <property type="entry name" value="zf_ZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="487"/>
            <end position="535"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="563" mass="62076" checksum="15D6024322A1FD94" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQI2</accession>
    <name>A0A670IQI2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IQI2"/>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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            <end position="428"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="428" mass="48875" checksum="FF152834880C0018" modified="2020-06-17" version="1">MRRKRGRCLKKPGWLSKELLTELRLKKDVYKKWKRGETTKEEFKQIASTCRHKVRKAKAQNELRLAREVKSNKKGFYGYVRSKRKNKETVGSLRGEDGEMQTGDTERAELLNAFFASVFSDKENNARPEEFGANDSAEETQPRITKEIVQEYLASLDVFKSPGPDELHPRVLKELADVISEPLAVIFENSWRTGEIPADWRRANVVPIFKKGKREDPNNYRPVSLTSIPGKILEQIIKQTVCEHLERNAVITNSQHGFLKNKSCQTNLISFFDRITSLGDEGNAVDVAYLDFSKAFDKVPHDVLVKKLVKCGLDYATTQWICNWLTDRTQRVLINGSSSSWRRVTSGVPQGSVFGPVLFIIFINDLDDGLKGILIKFADDTKLGGVANTPEDRITLQNDLDRLENWAKTNKMNFNREKCKVLHLGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRQ4</accession>
    <name>A0A670IRQ4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vomeronasal type-1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114604561</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028600609.1">
        <property type="nucleotide sequence ID" value="XM_028744776.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="Vmron_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394:SF137">
        <property type="entry name" value="C-X-C CHEMOKINE RECEPTOR TYPE 3 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TASTE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03402">
        <property type="entry name" value="V1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="148"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="208"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="262"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="23"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014783.1"/>
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    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="320" mass="36498" checksum="43FD928C812129B4" modified="2020-06-17" version="1">MVHDLMFMTSILMYLSSFVGMVGNLIVLFAFISNAIRHKSLQPLDRIIVNMSLVNFLLCCYKAIPGLLIFSSTKVFGELGCRILLYTYHTLRLISIWSVENLSFLHLIKIRRPSYRWSKFIYRHQGKYVNSTLAGCWIVSIFLQIPYLQYEKTVSRRNKTIAYLATSTCLRSTGSFAMKFTTYASVSLDLVFVMLVIVLNVFIIDLLCKHSRKVKAASSVTSGSWNKHTAQATKVLLSLLSIYVVCWISNDMVWIAIASGYIKSSFENSVLSALYGILSSVYYSASSYVVVFGYRKVREYLVEACWCLRCTRQTMVENLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRV9</accession>
    <name>A0A670IRV9_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">Neurochondrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCDN</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the neurochondrin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028738909.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028738910.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594744.1">
        <property type="nucleotide sequence ID" value="XM_028738911.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594746.1">
        <property type="nucleotide sequence ID" value="XM_028738913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IRV9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015760.1">
        <property type="protein sequence ID" value="ENSPMRP00000014755.1"/>
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    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00390000013601"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:neuron projection development"/>
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        <property type="term" value="P:regulation of postsynaptic neurotransmitter receptor internalization"/>
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        <property type="entry name" value="Neurochondrin"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="716" mass="78976" checksum="C915FF7FC5CA8670" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IS22</accession>
    <name>A0A670IS22_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NUDC</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028594561.1">
        <property type="nucleotide sequence ID" value="XM_028738728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IS22"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014949.1">
        <property type="protein sequence ID" value="ENSPMRP00000013987.1"/>
        <property type="gene ID" value="ENSPMRG00000009361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601516"/>
    <dbReference type="KEGG" id="pmua:114601516"/>
    <dbReference type="CTD" id="10726"/>
    <dbReference type="GeneTree" id="ENSGT00940000155361"/>
    <dbReference type="OMA" id="NQMEWWS"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051656">
        <property type="term" value="P:establishment of organelle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd06492">
        <property type="entry name" value="p23_mNUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032572">
        <property type="entry name" value="NuDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16273">
        <property type="entry name" value="NuDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="16">
        <location>
            <begin position="178"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="73"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="342" mass="39451" checksum="5FD4F54A8A94A4A1" modified="2020-06-17" version="1">MGASGEDGTDSEERFDGMLLAMAQQHQGGVRELVNTFFSFLRRKTDFFVGGEEGAAEKLITETFSRHNKLALKAQKEKKARQEAEKREKAERAAKLAKEEKQEESEPRIKELTEEEAERLQLEIDQKKEKKENEAQGIPSKPAENPVESPESSKQDTDEEEEDEKDKGKLKPNSGNGADLPNYRWTQTLSELDLAVPFKVNFRLKGKDMLVDIQRRHLKVGLKGHPPVIDEDLYNEVKVEESSWLIEDGKIVTVHLEKINKMEWWNKLVQTDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQDILKKFMEQHPEMDFSKAKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITS1</accession>
    <name>A0A670ITS1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Leucine rich repeat transmembrane neuronal 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LRRTM3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Postsynaptic cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the LRRTM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028585219.1">
        <property type="nucleotide sequence ID" value="XM_028729386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ITS1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016206.1">
        <property type="protein sequence ID" value="ENSPMRP00000015166.1"/>
        <property type="gene ID" value="ENSPMRG00000010122.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597178"/>
    <dbReference type="KEGG" id="pmua:114597178"/>
    <dbReference type="CTD" id="347731"/>
    <dbReference type="GeneTree" id="ENSGT00940000160543"/>
    <dbReference type="OMA" id="MIYCESQ"/>
    <dbReference type="OrthoDB" id="8731593at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000005">
        <property type="entry name" value="leucine-rich repeat transmembrane neuronal protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF218">
        <property type="entry name" value="LEUCINE RICH REPEAT TRANSMEMBRANE NEURONAL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025327552" evidence="14">
        <location>
            <begin position="31"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="15">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="574" mass="65269" checksum="8ED2B73BD95DDD3A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITZ5</accession>
    <name>A0A670ITZ5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Early growth response 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EGR4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGR C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ITZ5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016738.1">
        <property type="protein sequence ID" value="ENSPMRP00000015673.1"/>
        <property type="gene ID" value="ENSPMRG00000010467.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162199"/>
    <dbReference type="OMA" id="VENCIRC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000324">
        <property type="entry name" value="Early growth response protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000419">
        <property type="entry name" value="Early growth response protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF58">
        <property type="entry name" value="EARLY GROWTH RESPONSE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="424" mass="47349" checksum="B608424E5A7BD8A2" modified="2020-06-17" version="1">LLHLGHETGPWGATFYQLRLLVHLGQVWVLDLMPDLQCHREGPSPPVSYTGSFFIKTEQCQDQESLFNLMSGILDAAYSQSYSTFSSPDTVQQAQPSSDVGASSQCLFSEKLLDSKQDIKLSTISPSLEKFKSPCSHWDPLSQSQNYLPAEYTPPETFRPTEASQAMFPQLASKTENALSVSCQSELNGLPEQSGSFGHNLDFTCLPERFSTLTQIPSDFVEAKIPNLPPQLIQDFESSLPQAEVMPNLASTNDQRLHTSHTPPSTPMTDFLAHSSGSLVNPLAPSRTPVAVPEPKKKPRRGKCSSKCFCPKPHEKAFACPVENCIRCFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHIRTHTGEKPFSCDDCGRRFARSDEKKRHSKVHLKQKARAEEKLKGLGFYSVGLSFGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVT8</accession>
    <name>A0A670IVT8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">F-box/LRR-repeat protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">F-box and leucine-rich repeat protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FBXL7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest. It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase. Interacts with BIRC5; this interaction allows BIRC5 to be polyubiquitinated by the SCF(FBXL7) E3 ubiquitin-protein ligase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FBXL7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028593794.1">
        <property type="nucleotide sequence ID" value="XM_028737961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IVT8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016327.1">
        <property type="protein sequence ID" value="ENSPMRP00000015282.1"/>
        <property type="gene ID" value="ENSPMRG00000010193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601018"/>
    <dbReference type="KEGG" id="pmua:114601018"/>
    <dbReference type="CTD" id="23194"/>
    <dbReference type="GeneTree" id="ENSGT00940000158009"/>
    <dbReference type="OMA" id="ETVHVDR"/>
    <dbReference type="OrthoDB" id="423607at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22120">
        <property type="entry name" value="F-box_FBXL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000122">
        <property type="entry name" value="F-box/LRR-repeat protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000126">
        <property type="entry name" value="F-box/LRR-repeat protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000018">
        <property type="entry name" value="F-box/LRR-repeat protein 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF50">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="17">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="491" mass="54913" checksum="7531FE75B7858052" modified="2020-06-17" version="1">MGANNGKQYGSDGKGSSSLSSDVSSSTDHTPTKTQRNAATSEDSDLSMRTLSTPSPALICPPNSHILQNGRGSSTSSSSITGETIAMVHSPPPTRLTHPLIRSASRLQKERANIDRLPDHSVIQIFSFLPTNQLCRCARVCRRWYNLAWDPHLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVIVSGCRRLTDRGLYTIAQCCPELRQLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCIRITDEGLRYLMIYCTSIRELSVSDCRFVSDFGMREIAKLELRLRYLSIAHCARITDVGIRYIAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDAGLEFLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMMNVQDCEISVEALRFVKRHCKRCIIEHTNPAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IW42</accession>
    <name>A0A670IW42_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinase</fullName>
            <ecNumber evidence="6">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">IP6K2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="6"/>
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        <property type="nucleotide sequence ID" value="XM_028719152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IW42"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016426.1">
        <property type="protein sequence ID" value="ENSPMRP00000015377.1"/>
        <property type="gene ID" value="ENSPMRG00000010252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591712"/>
    <dbReference type="KEGG" id="pmua:114591712"/>
    <dbReference type="CTD" id="51447"/>
    <dbReference type="GeneTree" id="ENSGT00940000156310"/>
    <dbReference type="OMA" id="WANKKTH"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097243">
        <property type="term" value="F:flavonoid binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:inositol hexakisphosphate 5-kinase activity"/>
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    </dbReference>
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        <property type="term" value="P:cellular response to flavonoid"/>
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    </dbReference>
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        <property type="term" value="P:inositol phosphate biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of cell growth"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IPK_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="424" mass="49160" checksum="34995CB0E17A036D" modified="2020-06-17" version="1">MSPAFGAMEVEHYSKGVLLEPFVHQVGGHSCVLRFNDKTICKPLIQREHLFYETLPTEMRKFTPQYEGVVSVSFEEDEDGNLCLIAYPLNGDHDNLESLDNSECEPKNKLLRWTNKKTVLLENEKLTKEWVRQHRKEEKMKSHKLEEEFELLKKSEVLYYSVEKKGNVSSQFKHHNPWSMKCHQQQLKRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKKANQIRKCQQSTSAVIGVRVCGMQVYQPGSGQLMFMNKYHGRKLSVQGFKEALYQFFHNGKYLRRELFEPVLKKLTELKSVLEKQESYRFYSSSLLIIYDGKELQEVAVDSDPEDLEGLSEESSDESAGAYAYKPAASSVDVRMIDFAHTTCRYYGEDSVVHEGQDTGYVFGLQNLIVIIKEIRDESSE</sequence>
</entry>
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    <accession>A0A670IXG8</accession>
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        </submittedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IXG8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016953.1">
        <property type="protein sequence ID" value="ENSPMRP00000015877.1"/>
        <property type="gene ID" value="ENSPMRG00000010604.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="69" mass="7680" checksum="C9E9A5A0B98FDB7C" modified="2020-06-17" version="1">MKPCSLSFLEFTATLERSKVIEKNLKEDDISVAKDVKLHLLGTGESGKKHSCEAEETNQSFLTVRAVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXP1</accession>
    <name>A0A670IXP1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neurogenin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NEUROG3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IXP1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017853.1">
        <property type="protein sequence ID" value="ENSPMRP00000016750.1"/>
        <property type="gene ID" value="ENSPMRG00000011140.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163077"/>
    <dbReference type="OMA" id="AAWPACC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035883">
        <property type="term" value="P:enteroendocrine cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="bHLH_TS_NGN3_ATOH5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032656">
        <property type="entry name" value="Ngn3_bHLH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF171">
        <property type="entry name" value="NEUROGENIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="201" mass="21174" checksum="8A01F190B8807A39" modified="2020-06-17" version="1">PLAGAPRPRVSIAGELLLLRRRQGHPPPSSFLPSSPSPCLLLVEVGARAARGAPTKGRRGRGPGKGEGLGPSKAKRSRRMKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTETLRLADQNLAGAGPGPEVGAAFQQLGAGCDSLAAWPACCQWDAASLDSPGSQEGSLTLNWGGGNAPPQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXS7</accession>
    <name>A0A670IXS7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC1 domain family member 10C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TBC1D10C</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IXS7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018061.1">
        <property type="protein sequence ID" value="ENSPMRP00000016953.1"/>
        <property type="gene ID" value="ENSPMRG00000011247.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161287"/>
    <dbReference type="OMA" id="RPHRSSF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031527">
        <property type="term" value="C:filopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042113">
        <property type="term" value="P:B cell activation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050869">
        <property type="term" value="P:negative regulation of B cell activation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070885">
        <property type="term" value="P:negative regulation of calcineurin-NFAT signaling cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
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    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF17">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="105"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="394"/>
            <end position="438"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="450" mass="51513" checksum="3B52ED61E11FB9CD" modified="2020-06-17" version="1">MSDLTLSKELPDVSQAAADLPDAFDLSLNDDASSLGSDSELNGMPPYRQADRYGFIGGSSLQNGLGQPTVELIRHRETKWLEMTSHWEKTMARRYRKVKLLCRKGIPSSLRVRCWPLLCGGQAKMMRNPGKYQELQEIPGDPQWVETIRKDIHRQFPFHEMFLSPEGPGQQGLLQLLKAYTVYRPQEGYCQAQGPLGALLLMHMPAEQAFWCLVQICDCYLPGYYSPKMEALLLDSEVFVALLRRVCPKALKHLQKHGVGPLLYMPEWFLCLFTRSLPFPTVLRVWDAFLSEGIKVLFRVGMLLIRLALGSSEKLRDCAGVVETLEKLRSIPAHLLQEDTFMAEVHDVPISDRDLERECRAQLKKLRASRPDFQYSPELRLSGSKAIFDAQQLEYTRNDEEDPGSQKKMKTRKKPDTRGKTFHFMPRPTSRTEGRLEPDVVGRKSSFYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J077</accession>
    <name>A0A670J077_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670J077"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019057.1">
        <property type="protein sequence ID" value="ENSPMRP00000017908.1"/>
        <property type="gene ID" value="ENSPMRG00000011797.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154585"/>
    <dbReference type="OMA" id="NHSEGEC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16465">
        <property type="entry name" value="RING-H2_PJA1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000152">
        <property type="entry name" value="E3 ubiquitin-protein ligase Praja-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="620"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="681" mass="76535" checksum="49B361EB53823A23" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1G0</accession>
    <name>A0A670J1G0_PODMU</name>
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        <recommendedName>
            <fullName evidence="11">Trafficking protein particle complex subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tetratricopeptide repeat protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TRAPPC12</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="9">Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with CENPE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028722447.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578282.1">
        <property type="nucleotide sequence ID" value="XM_028722449.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578283.1">
        <property type="nucleotide sequence ID" value="XM_028722450.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578284.1">
        <property type="nucleotide sequence ID" value="XM_028722451.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028722452.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000017384.1"/>
        <property type="gene ID" value="ENSPMRG00000011497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593757"/>
    <dbReference type="KEGG" id="pmua:114593757"/>
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    <dbReference type="GeneTree" id="ENSGT00390000002448"/>
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    <dbReference type="OrthoDB" id="428342at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of protein localization to kinetochore"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090234">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Trafficking protein particle complex subunit 12"/>
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    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074587"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081147"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="788" mass="87518" checksum="E8CEB2E1BD1461FA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1L1</accession>
    <name>A0A670J1L1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G protein subunit alpha transducin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GNAT3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sensory perception of bitter taste"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050916">
        <property type="term" value="P:sensory perception of sweet taste"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050917">
        <property type="term" value="P:sensory perception of umami taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
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        <property type="entry name" value="Guanine nucleotide-binding protein G(t) subunit alpha"/>
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        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF66">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="163"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="257"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="342" mass="38975" checksum="E17FBD688F738F10" modified="2020-06-17" version="1">MGSGVSSESKESAKRSRELEKRLQEDAVRDARTVKLLLLGAGESGKSTIVKQMKIIHKDGYTDQECREYRSVVYSNMLQSILAIVKAMSTLGIEYGNSESKEDERQLLAIADSMEDGTMSSELAGIIKRLASEYQLNDSAAYYLNDLERITAPGYVPNEQDVLRSRVKTTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLLEDEEVNRMHESLHLFNSICNHKYFATTSIVLFLNKKDLFQEKILKVHLSVCFPEYDGSNTFEDAGNYIKNQFLDLNLRKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1T1</accession>
    <name>A0A670J1T1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Partitioning defective 3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Atypical PKC isotype-specific-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">PARD3</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="21">Interacts with PRKCZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PAR3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605820.1">
        <property type="nucleotide sequence ID" value="XM_028749987.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000019350.1">
        <property type="protein sequence ID" value="ENSPMRP00000018191.1"/>
        <property type="gene ID" value="ENSPMRG00000011980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607126"/>
    <dbReference type="KEGG" id="pmua:114607126"/>
    <dbReference type="CTD" id="56288"/>
    <dbReference type="GeneTree" id="ENSGT00950000183214"/>
    <dbReference type="OMA" id="WPNSKPY"/>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120157">
        <property type="term" value="C:PAR polarity complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051660">
        <property type="term" value="P:establishment of centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06691">
        <property type="entry name" value="PDZ1_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23058">
        <property type="entry name" value="PDZ2_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23059">
        <property type="entry name" value="PDZ3_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000078">
        <property type="entry name" value="Partitioning defective 3 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000011">
        <property type="entry name" value="partitioning defective 3 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000040">
        <property type="entry name" value="partitioning defective 3 homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000017">
        <property type="entry name" value="partitioning defective 3 homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF10">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="20" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="14" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="PDZ" evidence="26">
        <location>
            <begin position="271"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="26">
        <location>
            <begin position="461"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="26">
        <location>
            <begin position="590"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="159"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="856"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="928"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1093"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="1037"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="935"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="969"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1093"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1127"/>
            <end position="1140"/>
        </location>
    </feature>
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        <location>
            <begin position="1141"/>
            <end position="1168"/>
        </location>
    </feature>
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        <location>
            <begin position="1174"/>
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            <begin position="1205"/>
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        <location>
            <begin position="1276"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1338"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00065272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00070151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1347" mass="150421" checksum="38B10951F0CD24F4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3W6</accession>
    <name>A0A670J3W6_PODMU</name>
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        <recommendedName>
            <fullName evidence="10">ATP synthase subunit b</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J3W6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020127.1">
        <property type="protein sequence ID" value="ENSPMRP00000018951.1"/>
        <property type="gene ID" value="ENSPMRG00000012386.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001958"/>
    <dbReference type="OMA" id="NHETIVG"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="159" mass="18248" checksum="7F24848ABE91E71F" modified="2020-06-17" version="1">KASRMALSILAAYIYGTGLLLYMVSKELYIVNHETIVGGVMAGILIYIIKKYSADVAAFADKLNEDTIAQATSGENVMIADHTTAIEEKKEQGPLYLYLYYLFAIMLEANYRVRLFTVYTEVKKRLDYHVAIQHLRWNMEQNHMIIWVEQNIKPCDGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J460</accession>
    <name>A0A670J460_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Transmembrane emp24 domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">p24 family protein gamma-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">p27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">TMED7</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasmic vesicle</location>
            <location evidence="16">COPI-coated vesicle membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cytoplasmic vesicle</location>
            <location evidence="17">COPII-coated vesicle membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">cis-Golgi network membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Membrane</location>
            <topology evidence="21">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J460"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019487.1">
        <property type="protein sequence ID" value="ENSPMRP00000018324.1"/>
        <property type="gene ID" value="ENSPMRG00000012055.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158463"/>
    <dbReference type="OMA" id="VGEYTFC"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.680:FF:000013">
        <property type="entry name" value="Transmembrane emp24 domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="1"/>
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            <begin position="35"/>
            <end position="224"/>
        </location>
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        <location>
            <begin position="46"/>
            <end position="128"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004619"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080822"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="224" mass="25323" checksum="E2BD9124CABE6374" modified="2020-06-17" version="1">MLLRSWQGPGASLRLPAAALLLLLLLNLGWSVRASEITFELPDNAKQCFYEEIVQGTKCTLEFQVITGGHYDVDCRLEDPDGVVLYKEMKKQYDSFTFTASRNGTYKFCFSNEFSTFTHKTVYFDFQIGDDPPLFPSENRVTALTQMESACVSIHEALKSVIDSQTHFRLREAQGRSRAEDLNTRVAYWSVGEAIILLVVSIGQVFLLKSFFSDKRTTTTRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J6G3</accession>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
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                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
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    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSPMRG00000012541.1"/>
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            <begin position="6"/>
            <end position="25"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="100" mass="10683" checksum="3E98DCB3A3E82BCD" modified="2020-06-17" version="1">MGPTAAAVLFRLSFFTFACCLAVFLSHIGDTARIAPEFPGEDAPLDQLVQYYNDPPRCSNRRAGSSLDSNSWALDSWPGAPESLVPGCPAPLVPMVKTAL</sequence>
</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Wallerman O."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="293" mass="33534" checksum="C975DEFBB4539E0B" modified="2020-06-17" version="1">MPASQGFSCLNWCYSNAQWNLNWCELAVFYLFNTSEVLYHSLSERDLQIAHWKQETEALKKSYSLTTGLVTSLQKDITSKDHNIQQLKTEVEKFRRESREKDNQLAQVSDLCLCFLHTKKNPWDKGWCDFLQLILPTSLWCLQQISELELQVKRYKEDINKFRTEHGMLTNKLAEKTKLLQKQPRILCGEMSLHCCFKIRMTHTHVCVGLLLLSLFSCQDFLGTSYCSSSLRKEICNLQNLCLTPPALGVQTSTAGVLCSLLGWVDAVECLLRDVGLDVSGSEKGSLFQPCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8X8</accession>
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        </submittedName>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J8X8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021947.1">
        <property type="protein sequence ID" value="ENSPMRP00000020665.1"/>
        <property type="gene ID" value="ENSPMRG00000013428.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="217" mass="23146" checksum="443C227D0BCCAEF4" modified="2020-06-17" version="1">LASISPNVHGKPRSNQQVCRRLHMRRSRQSPPAPAHNGASPSDSFQPPDGPPEQIMVAGRGSTVAPICLVWAPLSCSSCLCPRRTRYSIIMTSVRGIWAFFLNSAPMGRADIPSGQPRSRAGAGEPKGAVSEQKLVGKFMGGAQARLEEGPGRSGSLSERKSALGLGSKTCIRGAKLNKIWGVPKIASAQTPEMCRHNPAHRAISVGVNWPRRGKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J963</accession>
    <name>A0A670J963_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GS homeobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GSX2</name>
    </gene>
    <organism evidence="13 14">
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        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028600229.1">
        <property type="nucleotide sequence ID" value="XM_028744396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J963"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022034.1">
        <property type="protein sequence ID" value="ENSPMRP00000020750.1"/>
        <property type="gene ID" value="ENSPMRG00000013473.1"/>
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    <dbReference type="GeneID" id="114604341"/>
    <dbReference type="KEGG" id="pmua:114604341"/>
    <dbReference type="CTD" id="170825"/>
    <dbReference type="GeneTree" id="ENSGT00940000156043"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:subpallium neuron fate commitment"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:telencephalon regionalization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="HD"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
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    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="186"/>
            <end position="246"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
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        <location>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JA64</accession>
    <name>A0A670JA64_PODMU</name>
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        <submittedName>
            <fullName evidence="7">Gastricsin-like</fullName>
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        <name evidence="7" type="primary">LOC114598356</name>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_028732032.1"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Acid Proteases"/>
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        <property type="entry name" value="Aspartic_peptidase_A1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF70">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
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    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025445255" evidence="5">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="385"/>
        </location>
    </feature>
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        <location>
            <position position="91"/>
        </location>
    </feature>
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        <location>
            <position position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="104"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021171.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="388" mass="43143" checksum="CAAF614EDA2E551A" modified="2020-06-17" version="1">MKWLILVLVCLHLSEGVERVILKKGKSIRENMKEKGVLEEFLKKNYVDPAAKYHLNEYNIAYEPITNYLNSFYFGQISIGTPPQDFLVVMDTGSSNLWVPSVYCSTAACENHNRFNPSASSTYYNNGQTYTLYYGSGDLTVMLGYDTVQVQNIVIQNQEFGLSENEPATPFYYANFDGILGMAYPALAVGGSYTAMQSMMRQGQLSEPIFSFYFSRQPTVQYGGELILGGVDTQLYSGEIAWAPVTRELYWQIGIEEFAIGDEATGWCSEGCQGIVDTGTCQLTIPQQYIGTFLQAIGAEQYNGEYVVNCNNVQNMPTITFVINGVQFPLPPSAYISESNGYCIAGIETTYLASSNGQPLWILGDVFLKEYYSVFDMANNRVGFAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JDW8</accession>
    <name>A0A670JDW8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AH receptor-interacting protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aryl-hydrocarbon receptor-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AIP</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JDW8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023119.1">
        <property type="protein sequence ID" value="ENSPMRP00000021784.1"/>
        <property type="gene ID" value="ENSPMRG00000014146.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001289"/>
    <dbReference type="OMA" id="SHCCGMM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036004">
        <property type="term" value="F:GAF domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000052">
        <property type="entry name" value="Aryl-hydrocarbon-interacting protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF3">
        <property type="entry name" value="AH RECEPTOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="330" mass="37984" checksum="4D18B1D167763CB2" modified="2020-06-17" version="1">MADQVEQLRADGIQKRLVQEGRGPQPDYQDGTKVTFHYRTLLCSPDQRVLDDSRTREKPMELIIGKKFKLPVWETILHTMREGEMAEFLCDTKHVVLYPMVSKSLRNIAAGKDPLEGQRHCCGIAQMHEHHSLGYPDLDELQQNPQPLIFAIEMLKVEVPGTYRQDPWAMSDDEKVKAVPLIHQEGNELYKEGKVQEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDQQITPLLLNYCQCKLLNEEYYEVLDHCSSILNKYEDNVKAYFKRAKAHAAVWNATEAQADFAKVLQLDPSLGPVVARELRSLETRLRQKEDEDKIRFKGIFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEG0</accession>
    <name>A0A670JEG0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-threonine protein phosphatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JEG0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024371.1">
        <property type="protein sequence ID" value="ENSPMRP00000022943.1"/>
        <property type="gene ID" value="ENSPMRG00000014895.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000185205"/>
    <dbReference type="OMA" id="RTLLCEC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine protein phosphatase N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="74" mass="8004" checksum="517B6E4587467D43" modified="2020-06-17" version="1">LQENEIRGLCLKSGEIFLGPPILLELEAPLKICGGIHAQSSQGLLRLLPRRTLLCECLRALLLPATHHLARGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJ36</accession>
    <name>A0A670JJ36_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kelch repeat and BTB domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">KBTBD8</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KBTBD8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028575283.1">
        <property type="nucleotide sequence ID" value="XM_028719450.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575285.1">
        <property type="nucleotide sequence ID" value="XM_028719452.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575286.1">
        <property type="nucleotide sequence ID" value="XM_028719453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JJ36"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025444.1">
        <property type="protein sequence ID" value="ENSPMRP00000023980.1"/>
        <property type="gene ID" value="ENSPMRG00000015522.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591859"/>
    <dbReference type="CTD" id="84541"/>
    <dbReference type="GeneTree" id="ENSGT00940000158653"/>
    <dbReference type="OMA" id="FWMYDHA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014032">
        <property type="term" value="P:neural crest cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014029">
        <property type="term" value="P:neural crest formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18274">
        <property type="entry name" value="BTB_POZ_KBTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000006">
        <property type="entry name" value="Kelch repeat and BTB domain-containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000014">
        <property type="entry name" value="kelch repeat and BTB domain-containing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000020">
        <property type="entry name" value="Kelch repeat and BTB domain-containing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028764">
        <property type="entry name" value="BTB/POZ_KBTBD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF433">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="575" mass="66072" checksum="01F7CBD1FAC44314" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJJ4</accession>
    <name>A0A670JJJ4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MAST4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026563.1">
        <property type="protein sequence ID" value="ENSPMRP00000025033.1"/>
        <property type="gene ID" value="ENSPMRG00000016149.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156399"/>
    <dbReference type="OMA" id="LERLGTX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23076">
        <property type="entry name" value="PDZ_MAST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF224">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="375"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="671"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="488"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="576"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="637"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="765"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="819"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1409"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1464"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1599"/>
            <end position="1654"/>
        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="366" mass="41025" checksum="CDC6D3CEAACF6ADA" modified="2020-06-17" version="1">MSYMHALPTESITQGQYCIKALLLLEGSIPLPRVLPWFLAILYHLVKLLDCRHSIFLDSYYFLLLCRCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTVNGASVNRVTRVSPGPLHCLKMILQKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEMLNNIFEPESTKVHMTSAGVAGFTAITATNPIWLIKTRLQLDARNRGEKRMSAFECVRRVYQTDGIKGFYRGMSASYAGISETVIHFVIYESIKRRLLEYKSASAMDEEDETVKEASDFVGMMMAAATSKTCATSIAYPHEVVRTRLREEGTKYRSFFQTLSLLVREEGYNALYRGLTTHLIRQIPNTAIMMSTYEVVVYLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQU8</accession>
    <name>A0A670JQU8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine palmitoyltransferase 1</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Long chain base biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Serine-palmitoyl-CoA transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SPTLC1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Required for adipocyte cell viability and metabolic homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:14762"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:35679"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:71008"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:35680"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:33683"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:65073"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:33684"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:35675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:71007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:35676"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028604303.1">
        <property type="nucleotide sequence ID" value="XM_028748470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JQU8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026907.1">
        <property type="protein sequence ID" value="ENSPMRP00000025347.1"/>
        <property type="gene ID" value="ENSPMRG00000016404.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606338"/>
    <dbReference type="KEGG" id="pmua:114606338"/>
    <dbReference type="CTD" id="10558"/>
    <dbReference type="GeneTree" id="ENSGT00550000074872"/>
    <dbReference type="OMA" id="LTKYGCG"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904504">
        <property type="term" value="P:positive regulation of lipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904649">
        <property type="term" value="P:regulation of fat cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046511">
        <property type="term" value="P:sphinganine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006686">
        <property type="term" value="P:sphingomyelin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000049">
        <property type="entry name" value="serine palmitoyltransferase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="20">
        <location>
            <begin position="101"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="475" mass="53214" checksum="9942062E3390F74C" modified="2020-06-17" version="1">MAAEGAGQQWVLVEMVQAFYEAPTYHLILEGILILWIIRLLFSKTYKLQERSDLTPKEKEELIEEWQPEPLVPPVSKDHPALNYNVVSGPPIHNIVVNGKECINFASFNFLGLLDNERVKNAAQNSLTKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFATIASAIPAYSKRGDIVFVDEAACFAIQKGLQASRSNIKFFKHNDMADLEHLLKEQEIEDQKNPRKARVTRRFIVVEGLYVNAGDICPLPELVKLKYKYKVRLFLEESLSFGVLGEHGRGVTEHFGINMDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEGLNIMEENPGIFQILRQKCKRIHQALQGIPGLRVVGQSISPALHLRLEESTGSRESDARLLKEIVDYCMNRGIALTQARYLEKEEKFLPPPSIRVVVTVEQTEPELDKAASLIREAAESVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRK0</accession>
    <name>A0A670JRK0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GNG10</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028567708.1">
        <property type="nucleotide sequence ID" value="XM_028711875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JRK0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027750.1">
        <property type="protein sequence ID" value="ENSPMRP00000026149.1"/>
        <property type="gene ID" value="ENSPMRG00000016923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587510"/>
    <dbReference type="KEGG" id="pmua:114587510"/>
    <dbReference type="CTD" id="2790"/>
    <dbReference type="GeneTree" id="ENSGT01100000263525"/>
    <dbReference type="OMA" id="YREPRSC"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="13">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="68" mass="7397" checksum="FD542AB6AA8CA45D" modified="2020-06-17" version="1">MSSNSSLSTMQRLVEQLKLEAGVERIRVSQAAAELQQYCMQNACKDALLVGVPAGSNPFREPRSCALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JS09</accession>
    <name>A0A670JS09_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dickkopf like acrosomal protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DKKL1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dickkopf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028559926.1">
        <property type="nucleotide sequence ID" value="XM_028704093.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559927.1">
        <property type="nucleotide sequence ID" value="XM_028704094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559928.1">
        <property type="nucleotide sequence ID" value="XM_028704095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JS09"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029501.1">
        <property type="protein sequence ID" value="ENSPMRP00000027813.1"/>
        <property type="gene ID" value="ENSPMRG00000017955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582806"/>
    <dbReference type="CTD" id="27120"/>
    <dbReference type="GeneTree" id="ENSGT00390000000221"/>
    <dbReference type="OMA" id="CCANHIS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039706">
        <property type="term" value="F:co-receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006796">
        <property type="entry name" value="Dickkopf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039863">
        <property type="entry name" value="DKK1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113:SF8">
        <property type="entry name" value="DICKKOPF-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113">
        <property type="entry name" value="DICKKOPF3-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04706">
        <property type="entry name" value="Dickkopf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025374487" evidence="8">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Dickkopf N-terminal cysteine-rich" evidence="9">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="373" mass="42489" checksum="0184EC66181DF0DB" modified="2020-06-17" version="1">MLLPLVWGFWCLTALMQGRTTASAAFLPPSVERLFKEFRNIFEQSREDVLGKDQLEPSVDISKLPSNYHNEEKHQRKVGNATVYSHREISKMTDNRTGEMVFSEKTVTSIEQADARPEEEEEDEQECVSDSDCQKDQFCFKSFLASRCRQCKVKNTICRKDRECCLGYLCVWGRCAKGVSRGQSGTRCDPRRDKCAQGLCCTASNSLSFPVCTPYPKEGEVCQIPTSSLFGLMGWGSLTAFPRPSQYCPCAQGLKCRAKRYTTVSTCENPENSVDISRPDQQLSFYQPILMRRYKEDAYYDDSVQDGQLALVNLPRSPYSMEDIGQPKGLSEDYDEKRQLPWEEDMADPKQADFQELKQLANEMGQYIGPGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSR9</accession>
    <name>A0A670JSR9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JSR9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029828.1">
        <property type="protein sequence ID" value="ENSPMRP00000028113.1"/>
        <property type="gene ID" value="ENSPMRG00000018145.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154901"/>
    <dbReference type="OMA" id="WLSYCST"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000023">
        <property type="entry name" value="Solute carrier family 22 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="101"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028113.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="539" mass="59070" checksum="BC34DD91F0692D55" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSW9</accession>
    <name>A0A670JSW9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Beta-hexosaminidase</fullName>
            <ecNumber evidence="20">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">HEXB</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-acetyl-beta-D-6-sulfogalactosaminyl-(1-&gt;4)-alpha-L-iduronyl-(1-&gt;3)-N-acetyl-D-6-sulfogalactosamine + H2O = alpha-L-iduronyl-(1-&gt;3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine</text>
            <dbReference type="Rhea" id="RHEA:64384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:152567"/>
            <dbReference type="ChEBI" id="CHEBI:152568"/>
            <dbReference type="ChEBI" id="CHEBI:153064"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:64385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide + H2O = a beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide + N-acetyl-beta-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:48276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28497"/>
            <dbReference type="ChEBI" id="CHEBI:90163"/>
            <dbReference type="ChEBI" id="CHEBI:90164"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:48277"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:47940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28497"/>
            <dbReference type="ChEBI" id="CHEBI:60065"/>
            <dbReference type="ChEBI" id="CHEBI:71502"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:47968"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28497"/>
            <dbReference type="ChEBI" id="CHEBI:79210"/>
            <dbReference type="ChEBI" id="CHEBI:79218"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:47969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-D-GalNAc-(1-&gt;4)-alpha-L-IdoA-(1-&gt;3)-beta-D-GalNAc-4-sulfate-(1-&gt;4)-alpha-L-IdoA-(1-&gt;3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1-&gt;3)-beta-D-GalNAc-4-sulfate-(1-&gt;4)-alpha-L-IdoA-(1-&gt;3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:64372"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28037"/>
            <dbReference type="ChEBI" id="CHEBI:152565"/>
            <dbReference type="ChEBI" id="CHEBI:152566"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:64373"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">There are 3 forms of beta-hexosaminidase: hexosaminidase A is a heterodimer composed of one subunit alpha and one subunit beta (chain A and B); hexosaminidase B is a homodimer of two beta subunits (two chains A and B); hexosaminidase S is a homodimer of two alpha subunits. The composition of the dimer (isozyme A versus isozyme S) has a significant effect on the substrate specificity of the alpha subunit active site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">Secretory vesicle</location>
            <location evidence="13">Cortical granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="20"/>
    <dbReference type="RefSeq" id="XP_028605157.1">
        <property type="nucleotide sequence ID" value="XM_028749324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JSW9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028204.1">
        <property type="protein sequence ID" value="ENSPMRP00000026589.1"/>
        <property type="gene ID" value="ENSPMRG00000017184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606774"/>
    <dbReference type="KEGG" id="pmua:114606774"/>
    <dbReference type="CTD" id="3074"/>
    <dbReference type="GeneTree" id="ENSGT00390000008107"/>
    <dbReference type="OMA" id="FTQNIFC"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042582">
        <property type="term" value="C:azurophil granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905379">
        <property type="term" value="C:beta-N-acetylhexosaminidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060473">
        <property type="term" value="C:cortical granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043615">
        <property type="term" value="P:astrocyte cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030207">
        <property type="term" value="P:chondroitin sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030209">
        <property type="term" value="P:dermatan sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070050">
        <property type="term" value="P:neuron cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007341">
        <property type="term" value="P:penetration of zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF38">
        <property type="entry name" value="BETA-HEXOSAMINIDASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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        <location>
            <begin position="21"/>
            <end position="555"/>
        </location>
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            <begin position="51"/>
            <end position="175"/>
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            <begin position="197"/>
            <end position="513"/>
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        <location>
            <position position="352"/>
        </location>
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        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
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        <location>
            <begin position="306"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043767"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026589.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="555" mass="62607" checksum="624D3B4376A180F2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JU84</accession>
    <name>A0A670JU84_PODMU</name>
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        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="12" type="primary">TRIM45</name>
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    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRIM/RBCC family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A670JU84"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Immunoglobulins"/>
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    </dbReference>
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        <property type="entry name" value="Znf-RING_euk"/>
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        <property type="entry name" value="Znf_B-box"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="581" mass="63796" checksum="1768C2A15C57BD1D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXG0</accession>
    <name>A0A670JXG0_PODMU</name>
    <protein>
        <recommendedName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="23">RING finger protein 167</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">RNF167</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 31">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the Godzilla family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028559294.1">
        <property type="nucleotide sequence ID" value="XM_028703461.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559295.1">
        <property type="nucleotide sequence ID" value="XM_028703462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JXG0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030308.1">
        <property type="protein sequence ID" value="ENSPMRP00000028570.1"/>
        <property type="gene ID" value="ENSPMRG00000018464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582434"/>
    <dbReference type="KEGG" id="pmua:114582434"/>
    <dbReference type="CTD" id="26001"/>
    <dbReference type="GeneTree" id="ENSGT00940000159547"/>
    <dbReference type="OMA" id="SHAYHAK"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036020">
        <property type="term" value="C:endolysosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035519">
        <property type="term" value="P:protein K29-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051966">
        <property type="term" value="P:regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02123">
        <property type="entry name" value="PA_C_RZF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16796">
        <property type="entry name" value="RING-H2_RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000099">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044744">
        <property type="entry name" value="ZNRF4/RNF13/RNF167_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0458">Lysosome</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 27" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025343616" description="E3 ubiquitin-protein ligase RNF167" evidence="27">
        <location>
            <begin position="29"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="28">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="279"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00067426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00080393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="383" mass="42270" checksum="1FB9E4D11842D7C6" modified="2020-06-17" version="1">MIRTQNPLPAAFLVLPVFLLLELPAAQGYIHAMSDHNSSMEFNDLPALFGEPLPHEGLVGFLVEAKPANACQAIEDAPVLSNGTVFIALIRRNDCSFDLKVFHAQKAGFRAAIVHNVGSDKLLNMVWDSEELRKLVTIPSVFIGEMAARLLRDSFTYEKGGQVILIPEYIFPLGYYLIPFTGVVGIVMAVMCTILIVRCIQHRKRMRRNRLSKEQLKKVPVHKYKKGDEYDVCAICLEEYEDGERLRILPCSHAYHCKCVDPWLTQTKKTCPVCKQRVLRSPDDSDSEGEEGLRAPQDEEEAGGQGGHGEEEEEEEGEEGGDSERTPLLRPSPSAALGGPSFGSIGQSPPSAAPQDHTQELGGEGDQDWDQTKGLLPRGPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXW3</accession>
    <name>A0A670JXW3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JXW3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031083.1">
        <property type="protein sequence ID" value="ENSPMRP00000029306.1"/>
        <property type="gene ID" value="ENSPMRG00000018942.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286953"/>
    <dbReference type="OMA" id="RTHMGEI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004135">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF377">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="215" mass="24510" checksum="D637573904B4CF54" modified="2020-06-17" version="1">SAKAVDQLYTPQHYQLSLTNQPNQPQINISHSIYTTRCRPCINLYFKKIIPSGDVWGVLDEEEPSDVWPERAEEQEKERKLGVQDGANKQEGERNSEAKGTVSQEDENQINRVEKKHECTVCGKRVCSCASLARHQSVHSGEKPHKCMECGKRFRNSGQLNVHQITHTGEKPYECMECGKSFRSSGHLTLHQRTHTGEKPYKCWECGKSFFDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYC7</accession>
    <name>A0A670JYC7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Novel acetylcholine receptor chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TMEM35A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DoxX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028571447.1">
        <property type="nucleotide sequence ID" value="XM_028715614.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028571448.1">
        <property type="nucleotide sequence ID" value="XM_028715615.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028571449.1">
        <property type="nucleotide sequence ID" value="XM_028715616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JYC7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031341.1">
        <property type="protein sequence ID" value="ENSPMRP00000029551.1"/>
        <property type="gene ID" value="ENSPMRG00000019109.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589317"/>
    <dbReference type="KEGG" id="pmua:114589317"/>
    <dbReference type="CTD" id="59353"/>
    <dbReference type="GeneTree" id="ENSGT00940000154325"/>
    <dbReference type="OMA" id="YQTSRRE"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030548">
        <property type="term" value="F:acetylcholine receptor regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000010">
        <property type="term" value="P:positive regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040399">
        <property type="entry name" value="TMEM35A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13163:SF0">
        <property type="entry name" value="NOVEL ACETYLCHOLINE RECEPTOR CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13163">
        <property type="entry name" value="SPINAL CORD EXPRESSION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="168" mass="18514" checksum="E3B2B01F1D31D31D" modified="2020-06-17" version="1">MASPRTITIVALSVALGLFFVFMGTIKLTPRLSRDAYNEMKRAYKSYIRALPMLKKMGVSSIILRKSIGALEVACGIVMTLVPGRPKDVANFLLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARQPEEQLPEKKTLSVNGEEQPPLAEAAPEKGKIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYP3</accession>
    <name>A0A670JYP3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="11">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UQCRFS1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="11">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A670JYP3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032231.1">
        <property type="protein sequence ID" value="ENSPMRP00000030398.1"/>
        <property type="gene ID" value="ENSPMRG00000019661.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001014"/>
    <dbReference type="OMA" id="PPYDFND"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.210.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.210.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011070">
        <property type="entry name" value="Globular_prot_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015248">
        <property type="entry name" value="UQCRFS1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09165">
        <property type="entry name" value="Ubiq-Cytc-red_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56568">
        <property type="entry name" value="Non-globular alpha+beta subunits of globular proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="176"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="273" mass="29391" checksum="46743BFEBDA2E651" modified="2020-06-17" version="1">MLSVAARSGPLAPYLSAAAHAVPGPLKPLAAGLAPAASKLPLDPKRPLLCRESLQGQAARGGLVATASLNAPASIRYVHNDVAVPDFSDYRRHDVTDAAKSSQESSESRKVFSYFMTATTCVATAYAAKNVVTQFVSSMSASADVLALSKIEIKLSDIPEGKNMTFKWRGKPLFVRHRTAKEIEQEAAVSLTDLRDPQHDLDRVKKPEWIILIGVCTHLGCVPISNAGEFGGYYCPCHGSHYDASGRIRKGPAPLNLEVPYYEFPSEDLVIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0L6</accession>
    <name>A0A670K0L6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prostate androgen-regulated mucin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PARM1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028557575.1">
        <property type="nucleotide sequence ID" value="XM_028701742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K0L6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030270.1">
        <property type="protein sequence ID" value="ENSPMRP00000028537.1"/>
        <property type="gene ID" value="ENSPMRG00000018436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581528"/>
    <dbReference type="KEGG" id="pmua:114581528"/>
    <dbReference type="CTD" id="25849"/>
    <dbReference type="GeneTree" id="ENSGT00390000014545"/>
    <dbReference type="OMA" id="LQSTEHM"/>
    <dbReference type="OrthoDB" id="8963138at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031431">
        <property type="entry name" value="PARM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35453">
        <property type="entry name" value="PROSTATE ANDROGEN-REGULATED MUCIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35453:SF1">
        <property type="entry name" value="PROSTATE ANDROGEN-REGULATED MUCIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17061">
        <property type="entry name" value="PARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025362267" evidence="3">
        <location>
            <begin position="27"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="307" mass="30692" checksum="43734E94929FEE80" modified="2020-06-17" version="1">MAHRGGRALAAFLLAVTAAGLNVSCASSPGPPTPSSTVPSETTEFNDSAATTSVGPPLSTQKGASMTVSLRFSTQDSTTASNTTVEALTANPVSAVTPLSRATVPDSSAATHSSPQPNTGLQTTEDTSAPATSVAGLVTGVAPHSETTPVSSLPTLNGSPTNPFPTNATYLSTTQVPSAGTSPEAMSSSKLPTGEATSGETSVAASSPGSTQGATISSHAAMSSKATPATSPTGSTTFSVGVTIQEVQRALSSGSIAAITITVIAVVLLVFGIAAFLKIRHSSYGRLLDDHDYGSWGNYNNPLYDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K234</accession>
    <name>A0A670K234_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CD99 antigen-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CD99L2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
            <orientation evidence="10">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD99 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028570259.1">
        <property type="nucleotide sequence ID" value="XM_028714426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K234"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032682.1">
        <property type="protein sequence ID" value="ENSPMRP00000030816.1"/>
        <property type="gene ID" value="ENSPMRG00000019965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588827"/>
    <dbReference type="KEGG" id="pmua:114588827"/>
    <dbReference type="CTD" id="83692"/>
    <dbReference type="GeneTree" id="ENSGT00940000154344"/>
    <dbReference type="OMA" id="KPDNSFW"/>
    <dbReference type="OrthoDB" id="8961553at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050904">
        <property type="term" value="P:diapedesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000391">
        <property type="term" value="P:positive regulation of neutrophil extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000409">
        <property type="term" value="P:positive regulation of T cell extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022078">
        <property type="entry name" value="CD99L2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15076:SF12">
        <property type="entry name" value="CD99 ANTIGEN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15076">
        <property type="entry name" value="CD99/MIC2 PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12301">
        <property type="entry name" value="CD99L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025612020" description="CD99 antigen-like protein 2" evidence="14">
        <location>
            <begin position="28"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="278" mass="29238" checksum="D6938FCDF1E11477" modified="2020-06-17" version="1">MTAKLWRPRLLLLAAVALVALSGRGYADDFDLNLEDALDDGIPTKRPTPKPPKKPSSGTGDLDLADYFDTPPEMTTKSTKVTTGPYPRKPDDIHWNVMHTTTKQPKTTKAPPKKVPAKDPMDFDLSDALDDHNPGQGGGTPNVNPGGGSKGTGGRGGKPGFSDDDLAGIVDEGGYQPDKKKGGSSGSGGSDNDGALVVETGTIAGIVSGLAMALIGAVSSYISYQQKKFCFSIQQGLNAEYVKGENMEAVVTEEPQVKYSVLEPQTAEPPPPQENAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3L7</accession>
    <name>A0A670K3L7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="3">2.7.7.49</ecNumber>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="3"/>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032610.1">
        <property type="protein sequence ID" value="ENSPMRP00000030750.1"/>
        <property type="gene ID" value="ENSPMRG00000019919.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240511"/>
    <dbReference type="OMA" id="DQHAIQL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0229">DNA integration</keyword>
    <keyword evidence="17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="20">
        <location>
            <begin position="195"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="739"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1125"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1169"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1209"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1141"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1178"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="1249"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1272"/>
            <end position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1286" mass="146364" checksum="5B6874165BABB8E4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3S2</accession>
    <name>A0A670K3S2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SLAIN motif-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114589010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLAIN motif-containing family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K3S2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033340.1">
        <property type="protein sequence ID" value="ENSPMRP00000031426.1"/>
        <property type="gene ID" value="ENSPMRG00000020370.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017860"/>
    <dbReference type="OMA" id="NTEPGSC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026179">
        <property type="entry name" value="Slain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22406">
        <property type="entry name" value="NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA, MUSCLE-SPECIFIC FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22406:SF5">
        <property type="entry name" value="SLAIN MOTIF-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15301">
        <property type="entry name" value="SLAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="670" mass="72859" checksum="B50B2642E423E18D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5C5</accession>
    <name>A0A670K5C5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K5C5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033969.1">
        <property type="protein sequence ID" value="ENSPMRP00000032031.1"/>
        <property type="gene ID" value="ENSPMRG00000020761.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="OMA" id="SRRECFT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002502">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000739">
        <property type="entry name" value="Zgc:171418 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001087">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="593" mass="68949" checksum="336D83B25117F866" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5G3</accession>
    <name>A0A670K5G3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DCAF13</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028592162.1">
        <property type="nucleotide sequence ID" value="XM_028736329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K5G3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032757.1">
        <property type="protein sequence ID" value="ENSPMRP00000030884.1"/>
        <property type="gene ID" value="ENSPMRG00000020001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600339"/>
    <dbReference type="KEGG" id="pmua:114600339"/>
    <dbReference type="CTD" id="25879"/>
    <dbReference type="GeneTree" id="ENSGT00390000005711"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044725">
        <property type="term" value="P:epigenetic programming in the zygotic pronuclei"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001555">
        <property type="term" value="P:oocyte growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007056">
        <property type="term" value="P:spindle assembly involved in female meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000132">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000269">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="14">
        <location>
            <begin position="354"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="445" mass="51489" checksum="7C006FCC9FC6A4E3" modified="2020-06-17" version="1">MKVKVLSRNPDDYVRETKQDLQRVPRNYDPALHPFEVPREYTRALNATKLDRVFAKPFVASLDGHRDGVNCMAKHPNSLSTVLSGACDGEVRIWNLMKRECTRTLQAHEGFVRGMCTRFCGTSFFTVGDDKTVKHWKMEAPAYGEAEEPLNTILGKTVYTGIDHHWKDPVFATCGHQVDIWDEQRTSPLCSLTWGVDSISSVKFNPIEMYLLGSCASDRNIVLYDMRQSTALKKVILDMRTNTLCWNPMEAFIFTAANEDFNLYTFDMRFLDKPVVVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKGHSREVYHTKRMQHVITVKWTSDNKYILCGSDEMNIRLWKANASEKLGVLLPREKAAMNYNEKLKEKFQHHPQIKRISRHRHLPKMIYSQAREQRIMREARRRKEMNRRKHSKPGSVPLVSEKKKHIVAVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K759</accession>
    <name>A0A670K759_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcipressin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Regulator of calcineurin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RCAN1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028582953.1">
        <property type="nucleotide sequence ID" value="XM_028727120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K759"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034071.1">
        <property type="protein sequence ID" value="ENSPMRP00000032130.1"/>
        <property type="gene ID" value="ENSPMRG00000020837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596070"/>
    <dbReference type="KEGG" id="pmua:114596070"/>
    <dbReference type="CTD" id="1827"/>
    <dbReference type="GeneTree" id="ENSGT00940000159870"/>
    <dbReference type="OMA" id="DTHEIHP"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031987">
        <property type="term" value="P:locomotion involved in locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070885">
        <property type="term" value="P:negative regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002931">
        <property type="term" value="P:response to ischemia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007614">
        <property type="term" value="P:short-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000221">
        <property type="entry name" value="calcipressin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF4">
        <property type="entry name" value="CALCIPRESSIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="273" mass="30451" checksum="FDAD0A017FE5CF14" modified="2020-06-17" version="1">MEDRGGGGRRERPRAGEAEEGEEPAETAAGEEEEEKAAAGVTVTITEPEGGEEDEDDDEDEAEERDTEWSFVDMETVSLRDLPTALIACNLPLPVFLPDGPCKARFEALFRTYDKDVTFQYFKSFKRVRINFSDPLSAADVKIQLHKKEFLGKELKLYFAQTLHIGSSRLAPPDPEKQFLISPPSSPPVGWTQSDDATPAINYDLLYAISKLGPGDQYELHAATETTPSVVVHVCDTNEEREADAERKDAKKAKPKPKIIQTRRPDYTPSYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7Z3</accession>
    <name>A0A670K7Z3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenomatous polyposis coli protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">APC2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="13">Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1.</text>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <name evidence="10" type="primary">NKX2-4</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <sequence length="366" mass="38485" checksum="1609408A3A51BD3A" modified="2020-06-17" version="1">MSLSPKHTTPFSVSDILSPMDETYKKFGAMDGSLGAPLGVGAAAYRQPQNAALPPPPQQHPMGAHNAAAAAYHSMAHAGVSQFAHGPVAGYCNGGLGNVGDLAPYPDSVRGSAAASGWYGANADPRYPTISRLMGPSGGMNMAGMGALSGIAEAAKSLAPGLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASLIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQHQPQTQTPPEGPGLCPQQPQQQAASPRRVAVPVLVKDGKPCPHSAAAAAGQSAGQAPSASGAGGSAAQHPQQQQQQQQQVTSLSQAPDLEEMSPSPPSLHSQVGALAQMDAAAVEYNGGLVNASLLYGRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8R4</accession>
    <name>A0A670K8R4_PODMU</name>
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        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K8R4"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
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        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
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        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
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        <location>
            <begin position="558"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="633"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="518"/>
            <end position="782"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="783" mass="88979" checksum="203EFBDA15A60767" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K926</accession>
    <name>A0A670K926_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cyclin E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CCNE2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin E subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K926"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035311.1">
        <property type="protein sequence ID" value="ENSPMRP00000033286.1"/>
        <property type="gene ID" value="ENSPMRG00000021549.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156934"/>
    <dbReference type="OMA" id="WPPTISG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097135">
        <property type="term" value="C:cyclin E2-CDK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20580">
        <property type="entry name" value="CYCLIN_CCNE2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20582">
        <property type="entry name" value="CYCLIN_CCNE2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000024">
        <property type="entry name" value="G1/S-specific cyclin-E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 8" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="136"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="10">
        <location>
            <begin position="230"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="387" mass="43926" checksum="E9A2CDEEE7DAFB54" modified="2020-06-17" version="1">YPLAVGDAALPRLAESLPAHRSLGRAELSTPQAATSRSSPTACGYCWPSTISGGISPCIIIETPHKEATTTDFSRFKKYRFRNLFINPSPLPELSWGNSKDVWFNILKKENKYSHCKHFTSLHSNLQPHMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKNLNKTMLQLIGITTLFIASKLEEIYAPKLQEFAYVTDGACSEDDIIRMELIILKALKWELCPVTIISWLNLYLQVDALKDVPKVLLPQYSQEKFIEIAQLLDLCILDVNSLDFQYRILAAAALCHYTSVHVVTRVSGLEWDSIAECVEWLKPFLKVAKKSPVKLKNFKKIAAEDRHNIQTHTNYLDMLDEVNYEVAVAAPGQLSPVSTGGIITPPKSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9G6</accession>
    <name>A0A670K9G6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Hyaluronan and proteoglycan link protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Brain link protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">HAPLN4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs. Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the HAPLN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028569764.1">
        <property type="nucleotide sequence ID" value="XM_028713931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K9G6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034999.1">
        <property type="protein sequence ID" value="ENSPMRP00000032990.1"/>
        <property type="gene ID" value="ENSPMRG00000021383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588547"/>
    <dbReference type="KEGG" id="pmua:114588547"/>
    <dbReference type="CTD" id="404037"/>
    <dbReference type="GeneTree" id="ENSGT00940000160926"/>
    <dbReference type="OMA" id="QACLQQD"/>
    <dbReference type="OrthoDB" id="5359219at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072534">
        <property type="term" value="C:perineuronal net"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150043">
        <property type="term" value="F:structural constituent of synapse-associated extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904862">
        <property type="term" value="P:inhibitory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051932">
        <property type="term" value="P:synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03518">
        <property type="entry name" value="Link_domain_HAPLN_module_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03519">
        <property type="entry name" value="Link_domain_HAPLN_module_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000536">
        <property type="entry name" value="Hyaluronan and proteoglycan link protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000001">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000002">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050691">
        <property type="entry name" value="Hyaluronan_bind_Proteoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804">
        <property type="entry name" value="AGGRECAN/VERSICAN PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804:SF11">
        <property type="entry name" value="HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01265">
        <property type="entry name" value="LINKMODULE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01241">
        <property type="entry name" value="LINK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0373">Hyaluronic acid</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025691865" description="Hyaluronan and proteoglycan link protein 4" evidence="16">
        <location>
            <begin position="27"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="18">
        <location>
            <begin position="160"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="18">
        <location>
            <begin position="260"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="375" mass="41848" checksum="8CFD5A531EE85A1F" modified="2020-06-17" version="1">MLPSRAVTGTCLHLAVLILCFRLAAPQKGRKKVVHVSEDDSGAVVVQTAPGKVVTHRGGTIILPCRFHYDVSAHDPDEIRLKWTKLVEPMSFEDVFVAMGVERRAFGSYRGRTALQEDGSGDASLIIRNVTLQDYGRYECEVTNELEDDAGMVNLDLEGVIFPYHPRLGRYSLNFHDAQQACLEQDGILASYDQLHEAWLEGMDWCNAGWLQDGSVQYPISKPRDECGRKETPVGVRNYGYRHKDDERYDAFCFTSNLNGKVYFLKTYRKLSFPEAVQACKKNGGAVAKVGQLYAAWKIQLLDKCEAGWVGDGSIRYPIVNPRSRCGGREPGVRNLGFPNKKYKLFGVYCYRSTTSGGSKAAAKEGAGKWKPLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAA3</accession>
    <name>A0A670KAA3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KAA3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035299.1">
        <property type="protein sequence ID" value="ENSPMRP00000033275.1"/>
        <property type="gene ID" value="ENSPMRG00000021576.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000168743"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF376">
        <property type="entry name" value="SERINE PEPTIDASE INHIBITOR, KUNITZ TYPE, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="218" mass="24653" checksum="5ED6055AF4E713C7" modified="2020-06-17" version="1">PPISGPGRRGLAHLRLGMPGDRPLCPFPAERFSHPTLPLGLASFDLAMDFGWSYGRCLSVYRNFYFDTVSGRCMTFIYSGCGGNANNFLHLLDCEAECINFDFYAPLSPPGLPLKCEQPKQTGLCKAMFPRYYYDVWDKKCTHFIYGGCGGNENNFISYLECYVACENPGKNEPLLMVIIDNKKNLQFLLNQVNAWVNNVSDRWHMEKGRCACLGRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAT4</accession>
    <name>A0A670KAT4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRAPPC1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex. The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028557978.1">
        <property type="nucleotide sequence ID" value="XM_028702145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KAT4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035512.1">
        <property type="protein sequence ID" value="ENSPMRP00000033475.1"/>
        <property type="gene ID" value="ENSPMRG00000021699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581700"/>
    <dbReference type="CTD" id="58485"/>
    <dbReference type="GeneTree" id="ENSGT00940000153761"/>
    <dbReference type="OMA" id="GKLMYGM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000004">
        <property type="entry name" value="Trafficking protein particle complex 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="145" mass="16920" checksum="0030FBB6FBA38E9E" modified="2020-06-17" version="1">MTVHNLYIFDRNGICLHYSEWNRKKQAGISKDEEFKLMYGMLFSIRSFVSKMSPVDMKDGFLAFQTSKYKLHYYETPTGLKVVMNTDLGVGNIRDILHQIYSYIYVEYVVKNPLCSLNENIQSELFRSKLDSFIRGLPFFSARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KC06</accession>
    <name>A0A670KC06_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Low density lipoprotein receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LDLR</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Endomembrane system</location>
            <topology evidence="21">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028567737.1">
        <property type="nucleotide sequence ID" value="XM_028711904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KC06"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037117.1">
        <property type="protein sequence ID" value="ENSPMRP00000035003.1"/>
        <property type="gene ID" value="ENSPMRG00000022649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587524"/>
    <dbReference type="KEGG" id="pmua:114587524"/>
    <dbReference type="CTD" id="3949"/>
    <dbReference type="GeneTree" id="ENSGT00940000161046"/>
    <dbReference type="OMA" id="KWICDGK"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034362">
        <property type="term" value="C:low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:lysosome"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1990666">
        <property type="term" value="C:PCSK9-LDLR complex"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036477">
        <property type="term" value="C:somatodendritic compartment"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097443">
        <property type="term" value="C:sorting endosome"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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    <dbReference type="GO" id="GO:0030169">
        <property type="term" value="F:low-density lipoprotein particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
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    <dbReference type="GO" id="GO:0030229">
        <property type="term" value="F:very-low-density lipoprotein particle receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150094">
        <property type="term" value="P:amyloid-beta clearance by cellular catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048844">
        <property type="term" value="P:artery morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071398">
        <property type="term" value="P:cellular response to fatty acid"/>
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    <dbReference type="GO" id="GO:0071404">
        <property type="term" value="P:cellular response to low-density lipoprotein particle stimulus"/>
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    <dbReference type="GO" id="GO:0042632">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0034384">
        <property type="term" value="P:high-density lipoprotein particle clearance"/>
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    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042159">
        <property type="term" value="P:lipoprotein catabolic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007616">
        <property type="term" value="P:long-term memory"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034383">
        <property type="term" value="P:low-density lipoprotein particle clearance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905907">
        <property type="term" value="P:negative regulation of amyloid fibril formation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061889">
        <property type="term" value="P:negative regulation of astrocyte activation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
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        <property type="term" value="P:negative regulation of low-density lipoprotein particle clearance"/>
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    <dbReference type="GO" id="GO:1903979">
        <property type="term" value="P:negative regulation of microglial cell activation"/>
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        <property type="term" value="P:negative regulation of receptor recycling"/>
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        <property type="term" value="P:phagocytosis"/>
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        <property type="term" value="P:phospholipid transport"/>
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        <property type="term" value="P:positive regulation of inflammatory response"/>
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        <property type="term" value="P:positive regulation of lysosomal protein catabolic process"/>
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        <property type="term" value="P:positive regulation of triglyceride biosynthetic process"/>
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        <property type="term" value="P:regulation of phosphatidylcholine catabolic process"/>
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        <property type="entry name" value="LDL receptor related protein 8"/>
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        <property type="entry name" value="Low density lipoprotein receptor"/>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
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        <property type="entry name" value="TolB, C-terminal domain"/>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
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        <property type="match status" value="7"/>
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        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="18" id="KW-0168">Coated pit</keyword>
    <keyword evidence="15 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0427">LDL</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA). Possesses both DNA unwinding and annealing activities. Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA. Efficiently unwinds substrates containing 3' overhangs or a D-loop. In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing. Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A670KDM4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037620.1">
        <property type="protein sequence ID" value="ENSPMRP00000035488.1"/>
        <property type="gene ID" value="ENSPMRG00000022889.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157350"/>
    <dbReference type="OMA" id="MFLNANI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097681">
        <property type="term" value="P:double-strand break repair via alternative nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000002">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001293">
        <property type="entry name" value="helicase POLQ-like isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000058">
        <property type="entry name" value="Helicase, POLQ like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="258"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="482"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114228" checksum="2C6A473708B712B2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGE7</accession>
    <name>A0A670KGE7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNL-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DNLZ</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028571225.1">
        <property type="nucleotide sequence ID" value="XM_028715392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KGE7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037498.1">
        <property type="protein sequence ID" value="ENSPMRP00000035370.1"/>
        <property type="gene ID" value="ENSPMRG00000022883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589211"/>
    <dbReference type="KEGG" id="pmua:114589211"/>
    <dbReference type="CTD" id="728489"/>
    <dbReference type="GeneTree" id="ENSGT00390000008220"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="176" mass="18961" checksum="C39FBD733418E049" modified="2020-06-17" version="1">MATTAACSGLLRRLGALTERLRRGTTRELGRGLWRTAPFPPPPPSFLATALQQRSLSGGARQEEEATQALKAASGYRLVYTCKVCGTRSAKTISKAAYHHGVVIVKCPGCQNHHIIADNLGWFSDLAGKRNVEEILAARGEKVRRVAGENAWEILLEDPQQTGTSDQPPDGDAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGP9</accession>
    <name>A0A670KGP9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ELAV-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ELAVL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RRM elav family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KGP9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035960.1">
        <property type="protein sequence ID" value="ENSPMRP00000033902.1"/>
        <property type="gene ID" value="ENSPMRG00000021981.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156823"/>
    <dbReference type="OMA" id="YPSCHSA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12771">
        <property type="entry name" value="RRM1_HuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12775">
        <property type="entry name" value="RRM2_HuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12654">
        <property type="entry name" value="RRM3_HuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000006">
        <property type="entry name" value="ELAV-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000005">
        <property type="entry name" value="ELAV-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000017">
        <property type="entry name" value="ELAV-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034999">
        <property type="entry name" value="HuB_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034914">
        <property type="entry name" value="HuB_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="177"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="328"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="411" mass="45346" checksum="3EA1BE19A2A0717F" modified="2020-06-17" version="1">MPLKTVKRLFQLPRSRCRQLQTNMAVRLCDVASLLRSGSWAAEPWTGQVIAAMETQLSNGPTCNNTANGPTTINNNCSSPIDSGNTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPPSATEPITVKFANNPSQKTNQAILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKRFSPMTIDGMTSLAGINIPGHAGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKG5</accession>
    <name>A0A670KKG5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH2 domain containing 3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SH2D3A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KKG5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039010.1">
        <property type="protein sequence ID" value="ENSPMRP00000036835.1"/>
        <property type="gene ID" value="ENSPMRG00000023731.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154130"/>
    <dbReference type="OMA" id="WWEANEE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10337">
        <property type="entry name" value="SH2_BCAR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000013">
        <property type="entry name" value="SH2 domain-containing protein 3C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051853">
        <property type="entry name" value="SH2-Ras-GEF_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044102">
        <property type="entry name" value="SH2_SHEP1/BCAR3/NSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247:SF11">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="278"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="539" mass="60273" checksum="B18D8B520534C1F3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KL43</accession>
    <name>A0A670KL43_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Far upstream element-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KH type-splicing regulatory protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KHSRP family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A670KL43"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039260.1">
        <property type="protein sequence ID" value="ENSPMRP00000037075.1"/>
        <property type="gene ID" value="ENSPMRG00000023871.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000156051"/>
    <dbReference type="OMA" id="QPVHQWA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22479">
        <property type="entry name" value="KH-I_FUBP2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22482">
        <property type="entry name" value="KH-I_FUBP2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22485">
        <property type="entry name" value="KH-I_FUBP2_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22488">
        <property type="entry name" value="KH-I_FUBP2_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000007">
        <property type="entry name" value="far upstream element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000008">
        <property type="entry name" value="far upstream element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000010">
        <property type="entry name" value="far upstream element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000049">
        <property type="entry name" value="far upstream element-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015096">
        <property type="entry name" value="FUBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047372">
        <property type="entry name" value="KH-I_FUBP2_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047369">
        <property type="entry name" value="KH-I_FUBP2_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047370">
        <property type="entry name" value="KH-I_FUBP2_rpt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047371">
        <property type="entry name" value="KH-I_FUBP2_rpt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09005">
        <property type="entry name" value="FUBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="K Homology" evidence="14">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="14">
        <location>
            <begin position="107"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="14">
        <location>
            <begin position="196"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="14">
        <location>
            <begin position="297"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="383"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="620" mass="66036" checksum="5B965498851528D8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLF7</accession>
    <name>A0A670KLF7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GJB1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the connexin family. Beta-type (group I) subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028715630.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028571464.1">
        <property type="nucleotide sequence ID" value="XM_028715631.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A670KLF7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037675.1">
        <property type="protein sequence ID" value="ENSPMRP00000035542.1"/>
        <property type="gene ID" value="ENSPMRG00000022981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589327"/>
    <dbReference type="KEGG" id="pmua:114589327"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Gap junction alpha-1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
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    </dbReference>
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        <property type="entry name" value="Connexin"/>
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    <dbReference type="InterPro" id="IPR002267">
        <property type="entry name" value="Connexin32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF20">
        <property type="entry name" value="GAP JUNCTION BETA-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01138">
        <property type="entry name" value="CONNEXINB1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0303">Gap junction</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="13">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="14">
        <location>
            <begin position="145"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="278" mass="31929" checksum="2C0ED1C6C9A03820" modified="2020-06-17" version="1">MKWEGFYALVIGVNRHSTAIGRIWLSVVFIFRIMVLVVAAESVWGDEQSSFTCNTQQPGCKNVCYDYYFPISHIRLWALQLILVTTPALLVAMHVAYQQHQEKKLLVMTGHGDPKHLEEVKKHKMRISGSLWWTYICSVIFRIVFEGTFMYIFYMIYPGYQMIRLVKCDVYPCPNTVDCFISRPTEKTVFTVFMLATSGICIILNLTEVVFLLVRACARRASKSHNPSSKKGSFLGHKLSEYKQNEINQLLTEQDGSLKDILRRNSGIQEKSDRCSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KMA9</accession>
    <name>A0A670KMA9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A670KMA9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038079.1">
        <property type="protein sequence ID" value="ENSPMRP00000035932.1"/>
        <property type="gene ID" value="ENSPMRG00000023210.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01090000262460"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="174" mass="19438" checksum="206B44568C0E2C76" modified="2020-06-17" version="1">MGGPESATTGPNEDNVKRPACGFSHPGTATRLQTCFWLSFNWHGSTATIIHSPGDEVWGVVGRMGTTDLPSLDRQEGVEEGIYIPIEVTVQTQEGKIKGCHIEEGERLFSAAPEKRTRSNGSKLQERRFHLNIRKNFLTVRAVRQWNLLPRSVVESPSLEVFKQRLDNHMSGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KNG4</accession>
    <name>A0A670KNG4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Serine/threonine-protein kinase 26</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Mammalian STE20-like protein kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">STK26</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Serine/threonine-protein kinase that acts as a mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer. Interacts with PDCD10. Interacts with GOLGA2. Interacts with CTTNBP2NL. Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho-independent manner. Interacts with PDCD10; this interaction is required for the association of STK26 with RIPOR1. Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028571770.1">
        <property type="nucleotide sequence ID" value="XM_028715937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KNG4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038721.1">
        <property type="protein sequence ID" value="ENSPMRP00000036552.1"/>
        <property type="gene ID" value="ENSPMRG00000023575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589529"/>
    <dbReference type="KEGG" id="pmua:114589529"/>
    <dbReference type="CTD" id="51765"/>
    <dbReference type="GeneTree" id="ENSGT00940000157904"/>
    <dbReference type="OMA" id="YYGCFLD"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005798">
        <property type="term" value="C:Golgi-associated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903698">
        <property type="term" value="P:positive regulation of microvillus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06640">
        <property type="entry name" value="STKc_MST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.70:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000252">
        <property type="entry name" value="Serine/threonine-protein kinase 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035056">
        <property type="entry name" value="STK_MST4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="14 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="24"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="298"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00056768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00065963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00072159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="416" mass="46865" checksum="D01E97D0288C27DD" modified="2020-06-17" version="1">MAHSPVAMQVPGMQNHRADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKGTKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLIGDFSKPFKEFIDACLNKDPTFRPTAKELLKHKFILKNAKKTSYLTELIDRFKRWKAEGHSSDETDSDGSDSESSNKENNSHPEWSFTTVRKKPEAKKLQNGTDQDLMKTLSCLTMIITPVFAELKQQDTNNASRKKAIEELEKSINMAEATCPGITDKMVKKLMEKFQKFSVNDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KNJ5</accession>
    <name>A0A670KNJ5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="3">2.7.7.49</ecNumber>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="3"/>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038755.1">
        <property type="protein sequence ID" value="ENSPMRP00000036587.1"/>
        <property type="gene ID" value="ENSPMRG00000023592.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240511"/>
    <dbReference type="OMA" id="MAREYDQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0229">DNA integration</keyword>
    <keyword evidence="17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="20">
        <location>
            <begin position="222"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="766"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1048"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1152"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1261"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1168"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="1276"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1303"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1467"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1498" mass="167846" checksum="92B27CBFA8CF382C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HKN3</accession>
    <name>A0A670HKN3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114590641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028572861.1">
        <property type="nucleotide sequence ID" value="XM_028717028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HKN3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000026.1">
        <property type="protein sequence ID" value="ENSPMRP00000000025.1"/>
        <property type="gene ID" value="ENSPMRG00000000020.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114590641"/>
    <dbReference type="KEGG" id="pmua:114590641"/>
    <dbReference type="GeneTree" id="ENSGT00940000164539"/>
    <dbReference type="OMA" id="ETGGCRM"/>
    <dbReference type="OrthoDB" id="9420729at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000007">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF7">
        <property type="entry name" value="SOUL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="286" mass="31444" checksum="00A72ECE69620980" modified="2020-06-17" version="1">MESQARTCLLSGGGGGGGDPAPPGAITLEELERAGAAGGEEAEAPGAAGCPDSAYGSSLEDNAGGDEQEQERLLSYWQSVGRGHRVDVPRDMAEPIQQLTRNNHPQERESVPFVVIARKEQLGNLLYEKRHYEKAKWACVKVQEKQYEQSICLGFMKIMRYICQQNSSGLYLGMTVPIATIVRTSESTPGITRFVTVAYYLPSGLQEQPPAPNDPDVVIEEWPPTIIYARGFRGVTNETSIAREINLLAELLESPELCLQDTFIVAGYTNPAATNRQNEIWFLERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HLA1</accession>
    <name>A0A670HLA1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HLA1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000426.1">
        <property type="protein sequence ID" value="ENSPMRP00000000403.1"/>
        <property type="gene ID" value="ENSPMRG00000000305.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000211035"/>
    <dbReference type="OMA" id="EANEWGL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="451" mass="47566" checksum="BC6793753607763C" modified="2020-06-17" version="1">GSHGPRPMSPWGPSPPSAAGRRKRSKLTPPATAGQQCPPPWLLPPWTKQRQPQQLISPNPQGGLPPAPPPTPPPAPPLPQAGLQPVPEAAAGAMGEHHTLLGLHHQADLHTPSLAPHEQTSQQPSPPTETAQQDRLPGLQVPRAAQLARPHQATPEGRGRSAGNALSQGPQPQRQGLAGQPRSAQRRGTSVGRRPAADLHQALAKGLGKGRGRPCVEYPVCLLCGRCTPYCPHPPTRYSPSLVVYPRLSVREGEVHMGLGFLLKIKRSEANEWGLVCKPDASRTRPGKEGLPSKLDRSKGQAAEEQGSHPPASGAREGCPRAQAAVGREAGPEAEKPRPERPETHPATENEARAGTPNAGPQHGACRAPQEAPQHPEAAASLHQERLGEGARQTCQAPQETGLPACPAQVPGEAVVPFVLSRRLQAPKPRGDLAPQAGLSAHKYKCLGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HLR0</accession>
    <name>A0A670HLR0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger and SCAN domain containing 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HLR0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000277.1">
        <property type="protein sequence ID" value="ENSPMRP00000000265.1"/>
        <property type="gene ID" value="ENSPMRG00000000185.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153104"/>
    <dbReference type="OMA" id="SVERTHC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000258">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001530">
        <property type="entry name" value="Zinc finger protein 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000361">
        <property type="entry name" value="Zinc finger protein 658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
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        <text evidence="5 14">Homodimer.</text>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="347" mass="38285" checksum="18815BADD0CDDB6A" modified="2020-06-17" version="1">MAITRTTTFKYNALLNRTTLTHGKQYACAPRGVRHSTFPAPLAFLKRQSACALASLAFFGPCGRRWSERVRKEAGLGKERPFPIGSFSTASGPRPPGEPPRQSQLRPPHGILRLRAGRRLIAASPLSRRLARGGGEERRRESAARARGGTPLAVSAAMMPAATVKPDTMPLYDPCLLQELDWSQNTVTFSPAISPVEPGSGLVLRPLCIADINKGFLKVLGQLTETGSASPEQFIKTFEHMKSSGDYYVTVVEDTILGEIVATATLVIEHKFTHSCAKRGRIEDVVVSGECRGKQLGKLLMSTLTLLSKRLKCYKITLECQPKNVAFYEKFGYSVSEENYMYQRFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
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                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HMY5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000358.1">
        <property type="protein sequence ID" value="ENSPMRP00000000337.1"/>
        <property type="gene ID" value="ENSPMRG00000000259.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010806"/>
    <dbReference type="OMA" id="QANEWPE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="209" mass="23395" checksum="A68FF76B7FFE9924" modified="2020-06-17" version="1">MTDWETAPAVAETPDIKLFGKWMRPIGRKKRYIAVKEKYAKYLPHSAGCYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIIKHAFEITHLLTGENPLQVLVNAIISSGPREDSTRIGRAGTVRRQAVDVSVTFASCQSSSNSQEVPGPKEVRLTSTSARAFSTLAPAWWNALSLETRALRDLISFRRACKTELFHLAFGSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNY7</accession>
    <name>A0A670HNY7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYG1 exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MYG1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HNY7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001313.1">
        <property type="protein sequence ID" value="ENSPMRP00000001241.1"/>
        <property type="gene ID" value="ENSPMRG00000000915.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010265"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035641">
        <property type="term" value="P:locomotory exploration behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000959">
        <property type="term" value="P:mitochondrial RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="358" mass="40561" checksum="EDD858ADD77A758F" modified="2020-06-17" version="1">MRMRRVLAGLPRLTRSLMPGPKRPRPARIGTHGGTFHCDEALACFLLRLLPSYQDAEIIRTRDAQLLSECDVVVDVGGEYDPQKHRYDHHQRSFGESMHSLKPDKPWQTKLSSAGLVYTHFGSEILANQLGLKEEDPVVRVLYDKLYENFVEEIDAIDNGISQWEGEPRYAMTTNVSSRVAYLNPRWNDKDQDTEPGFQKAMELVGNEFLDRLDYYYRAWIPARTLVEKAIQQRFEVDPSGEILVLAQGGCPWKEHLFNLEQELGVKKPLKFVLYTDLGGQWRVQCVPAGLHTFQNRLSLLAEWCGLRDEELSQASGIPGCVFVHSSGFIGGNHTKEGALEMARKTLARQVEPGTCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNZ1</accession>
    <name>A0A670HNZ1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger and SCAN domain-containing protein 23-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114592205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HNZ1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001670.1">
        <property type="protein sequence ID" value="ENSPMRP00000001569.1"/>
        <property type="gene ID" value="ENSPMRG00000001171.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000038">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="10">
        <location>
            <begin position="155"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
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    </feature>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="656" mass="71709" checksum="D37E22EECA38B998" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Episquamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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            <end position="46"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQ58</accession>
    <name>A0A670HQ58_PODMU</name>
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        <recommendedName>
            <fullName evidence="13">Claudin-34</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQ58"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001259.1">
        <property type="protein sequence ID" value="ENSPMRP00000001192.1"/>
        <property type="gene ID" value="ENSPMRG00000000880.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005717"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="224"/>
        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47827" checksum="5AAF38EB44E0B28E" modified="2020-06-17" version="1">MSSKVSPGPLLSKPPLRVKEGSLVVRWLRLVSCLRLCAFLMDIMAWMMCIASIAIVNWRVWRVENIKGIGSGNIWIGIWQVCFLKDPLNDGNYYYHCEELHEQHPNLPREIFIAQDLMALAAIMNSAALGLQSFALCNVFEPRKHKDFLSTFFGLGALLNLPAGILILISVIWNMSAVLQNGGIDFPETFELPQIPSEQHIGPSIYLGYIAAGFQLLSAAFVGMERCCIRTTTTDTSQIETVVVITPGSAVKSESLTTCSKCGSLLDLVIQEKSSAVEMEETHAEDLVKSCAVEMEEGCASDLVTPEESCTVEMEESCASDLVIPEESCTVEMKEGCASDLVIPEESCTVEMEESCASDLVIPEESCTVEMEESCASDLVIPEESCTVEMEESCASDLVIPEESCAVEMEESHTPKGYLKDIKGHLMSPNIRLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQ99</accession>
    <name>A0A670HQ99_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Epithelial cell adhesion molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EPCAM</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EPCAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028580849.1">
        <property type="nucleotide sequence ID" value="XM_028725016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HQ99"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001982.1">
        <property type="protein sequence ID" value="ENSPMRP00000001863.1"/>
        <property type="gene ID" value="ENSPMRG00000001376.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594845"/>
    <dbReference type="KEGG" id="pmua:114594845"/>
    <dbReference type="CTD" id="4072"/>
    <dbReference type="GeneTree" id="ENSGT00390000018245"/>
    <dbReference type="OMA" id="CNGSTCW"/>
    <dbReference type="OrthoDB" id="8953056at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000048">
        <property type="term" value="P:negative regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000648">
        <property type="term" value="P:positive regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023019">
        <property type="term" value="P:signal transduction involved in regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001657">
        <property type="term" value="P:ureteric bud development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049420">
        <property type="entry name" value="EPCAM-Trop-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043406">
        <property type="entry name" value="EPCAM/Trop-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041630">
        <property type="entry name" value="EpCAM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14168:SF4">
        <property type="entry name" value="EPITHELIAL CELL ADHESION MOLECULE PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14168">
        <property type="entry name" value="TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21283">
        <property type="entry name" value="EPCAM-Trop-2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18635">
        <property type="entry name" value="EpCAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025636867" evidence="11">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="12">
        <location>
            <begin position="60"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="308" mass="34212" checksum="B71000BF7B258988" modified="2020-06-17" version="1">MELPRGTVYLALAMLALAATVNSSCSCLNNKLTVNCISAGNTCRCTSLGSNVTVDCGTLSTKCLLMKAEIYRKNTGRMGRPQHAIRDNDGIYDPECDDNGNFKAKQCNGTDTCWCVNSAGVRRTDKGGKDIKCEEVVRTSWISMEMKHSGTETDVDKPSLESEIREELSLRYKLNKNHITATYEKPFVFIELKQNATEKSATDVDIVDVAYYFEKDIKGDSLIIGPRLTLDSSAGSLQSNDVIIYYIDDKAPEFTMQHLNPGIIAVIVIIILAIVAGILVLVFTRRKKGKYEKAEVKEMNEMHRELNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQP5</accession>
    <name>A0A670HQP5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipase B1, membrane-associated</fullName>
            <ecNumber evidence="5">3.1.1.3</ecNumber>
            <ecNumber evidence="4">3.1.1.4</ecNumber>
            <ecNumber evidence="3">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Phospholipase A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Phospholipase B/lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Triacylglycerol lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="47" type="primary">PLB1</name>
    </gene>
    <organism evidence="47 48">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="47 48" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="47" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="47" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:40924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:40975"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:40976"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41223"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:41224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39939"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:39940"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40983"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
            <dbReference type="ChEBI" id="CHEBI:77619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:40984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40979"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75585"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40980"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40915"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:34112"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:40916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
            <dbReference type="ChEBI" id="CHEBI:77624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41104"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41107"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75558"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:40812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40971"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:40972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40919"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72841"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40920"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40911"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:40912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = 1-octadecanoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40927"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75550"/>
            <dbReference type="ChEBI" id="CHEBI:77097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:42605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38491"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:38492"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36702"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:36232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="5"/>
    <dbReference type="EC" id="3.1.1.4" evidence="4"/>
    <dbReference type="EC" id="3.1.1.5" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670HQP5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001645.1">
        <property type="protein sequence ID" value="ENSPMRP00000001545.1"/>
        <property type="gene ID" value="ENSPMRG00000001132.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063883"/>
    <dbReference type="OMA" id="KYMQRED"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050253">
        <property type="term" value="F:retinyl-palmitate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000344">
        <property type="term" value="P:positive regulation of acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000005">
        <property type="entry name" value="Phospholipase B1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF52">
        <property type="entry name" value="PHOSPHOLIPASE B1, MEMBRANE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="48" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00033022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00045916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00048699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00048869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00048872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00048939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00049363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00049372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00049461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="47">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="48">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="910" mass="101579" checksum="FDE9CB03B92A0F0F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQX2</accession>
    <name>A0A670HQX2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCAN box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HQX2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002228.1">
        <property type="protein sequence ID" value="ENSPMRP00000002093.1"/>
        <property type="gene ID" value="ENSPMRG00000001537.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="OMA" id="RPERHTI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="3">
        <location>
            <begin position="125"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="260" mass="29067" checksum="6237647776832E72" modified="2020-06-17" version="1">MALAGVGEPSASCLQFPAALERWLQMGLTPESEEEGQAGAMGQFLRWTVEQMKQEPTQGVLSRHWEAQWQAFLKASRFPGSDWGDPQTVLRGGGKIFLPHRSIGRQIMAEQGADSPAALGAEAQRQSFRRFRYQEAEGPHEVCSRLWYLCHRWLKPERHTKEQILELVILEQFLAVLPPEMRSRVQEGGPETCSQAVALAEELLLGQREAEEEQVSGLSQVLKFPDDEEEQASSESGQGLLRGEIKQESGDYAISLGQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTI3</accession>
    <name>A0A670HTI3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium-activated potassium channel subunit alpha-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">BK channel</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">BKCA alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Calcium-activated potassium channel, subfamily M subunit alpha-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">K(VCA)alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">KCa1.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Maxi K channel</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Slo-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Slo1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Slowpoke homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">KCNMA1</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HTI3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003267.1">
        <property type="protein sequence ID" value="ENSPMRP00000003049.1"/>
        <property type="gene ID" value="ENSPMRG00000002147.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154935"/>
    <dbReference type="OMA" id="YWCKQCH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000098">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF40">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="30">
        <location>
            <begin position="402"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="30">
        <location>
            <begin position="777"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="699"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1124"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="1157"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00030518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00030652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00031597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1172" mass="130411" checksum="E117A60357988C15" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWI5</accession>
    <name>A0A670HWI5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Signal recognition particle 9 kDa protein</fullName>
            <shortName evidence="10">SRP9</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SRP9</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with SRP14; binds RNA as heterodimer. Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SRP9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028580366.1">
        <property type="nucleotide sequence ID" value="XM_028724533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HWI5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004378.1">
        <property type="protein sequence ID" value="ENSPMRP00000004104.1"/>
        <property type="gene ID" value="ENSPMRG00000002803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594620"/>
    <dbReference type="KEGG" id="pmua:114594620"/>
    <dbReference type="CTD" id="6726"/>
    <dbReference type="GeneTree" id="ENSGT00390000018505"/>
    <dbReference type="OMA" id="YYQVWEE"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000001">
        <property type="entry name" value="Signal recognition particle 9 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008832">
        <property type="entry name" value="SRP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017029">
        <property type="entry name" value="Signal_recog_particle_SRP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP9" evidence="11">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="86" mass="10228" checksum="1E0D9D8C69AF1033" modified="2020-06-17" version="1">MPHYQTWEEFTRAAEKLYMSDPMKVRVVLKYRHCDGNLCIKVTDDVVCLLYRTDQAQDVKKIEKFHSQLMRLMVAKESRSVVMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXF5</accession>
    <name>A0A670HXF5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Testis expressed 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TEX26</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028582271.1">
        <property type="nucleotide sequence ID" value="XM_028726438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HXF5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004068.1">
        <property type="protein sequence ID" value="ENSPMRP00000003802.1"/>
        <property type="gene ID" value="ENSPMRG00000002633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595777"/>
    <dbReference type="KEGG" id="pmua:114595777"/>
    <dbReference type="CTD" id="122046"/>
    <dbReference type="GeneTree" id="ENSGT00390000009484"/>
    <dbReference type="OMA" id="DTNWDSY"/>
    <dbReference type="OrthoDB" id="5984625at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043460">
        <property type="entry name" value="MEDAG/TEX26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33769:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33769">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 26 ISOFORM X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="322" mass="36824" checksum="E0F51D76D94F4520" modified="2020-06-17" version="1">MEPPEREAGPLLPPIHGTAMPPPPASIPFIPPWRPRSARPAPPVGRLKWDPYETTMRHDFVFNPATDPGADCARAGKGHVIPFQVDEPTGRNNYRDEFCWKPYSKAEPIRAGSARRNNPQPGERFLIWQMPREETPISIESYSPWTKPISKQEIEDVLKKQYKTAYARDYLGIQPGAPRDGAPAPSDWKMLVPKPPDTEFRHNYQPQANNPDLRDYTWKYGCNAKRHIPVKGAVPSVSFAQIWNHEHTKHLTTYQRDFGKDYNEILSVLNSLDPEEIKAYVDRAPLPEKTILQNFLERVSGDKKFQRPSSSKKLEENPVKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HYK5</accession>
    <name>A0A670HYK5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">NIF3-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NIF3L1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 9">May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homodimer. Interacts with COPS2. Interacts with THOC7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028607008.1">
        <property type="nucleotide sequence ID" value="XM_028751175.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028607024.1">
        <property type="nucleotide sequence ID" value="XM_028751191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HYK5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004501.1">
        <property type="protein sequence ID" value="ENSPMRP00000004217.1"/>
        <property type="gene ID" value="ENSPMRG00000002889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607741"/>
    <dbReference type="KEGG" id="pmua:114607741"/>
    <dbReference type="CTD" id="60491"/>
    <dbReference type="GeneTree" id="ENSGT00390000003590"/>
    <dbReference type="OMA" id="KYHEFFD"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000004">
        <property type="entry name" value="NIF3-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017222">
        <property type="entry name" value="DUF34/NIF3_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037490">
        <property type="entry name" value="UCP037490_NIF3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="375" mass="41415" checksum="059ACB312C722A60" modified="2020-06-17" version="1">MQLNWIPRQFLHIRSLINLTVRSFMDLKVLVSSLNDFASLSLAESWDNVGLLVEPSPPHSVHTLFLTNDLTEEVMEEALQKKADLILSYHPPIFQPLKRITWKTWKERLVIRALENRIGIYSPHTAYDAVPHGVNNWLAKGLGACISAPLQPATASSYPTGGSFRVEFTACLDDNLDTILTRLRGVPEVSLITTVPARVEGEEQTRVGVNCTQQALLQVVALLSQNSLLYQKTEIVSLQKPLLEDTGMGRLCALKEPASISVLVERVKSHLRLSHIRLALGAGKSLESQVKVVALCAGSGSSVLKGTESDLYLTGEMSHHDVLDAVSKGISVILCEHSNTERGFLLELQKELAVHLQNKICIVVSERDRDPLQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I117</accession>
    <name>A0A670I117_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Adenosine receptor A1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ADORA1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14 15">Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cell membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I117"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005942.1">
        <property type="protein sequence ID" value="ENSPMRP00000005584.1"/>
        <property type="gene ID" value="ENSPMRG00000003805.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234555"/>
    <dbReference type="OMA" id="FCCKDTP"/>
    <dbReference type="OrthoDB" id="5984709at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001609">
        <property type="term" value="F:G protein-coupled adenosine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060079">
        <property type="term" value="P:excitatory postsynaptic potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050900">
        <property type="term" value="P:leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060292">
        <property type="term" value="P:long-term synaptic depression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070254">
        <property type="term" value="P:mucus secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002686">
        <property type="term" value="P:negative regulation of leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900453">
        <property type="term" value="P:negative regulation of long-term synaptic depression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070256">
        <property type="term" value="P:negative regulation of mucus secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003093">
        <property type="term" value="P:regulation of glomerular filtration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051930">
        <property type="term" value="P:regulation of sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014074">
        <property type="term" value="P:response to purine-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15071">
        <property type="entry name" value="7tmA_Adenosine_R_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000061">
        <property type="entry name" value="Adenosine receptor A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001068">
        <property type="entry name" value="Adeno_A1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001634">
        <property type="entry name" value="Adenosn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF1">
        <property type="entry name" value="ADENOSINE RECEPTOR A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00552">
        <property type="entry name" value="ADENOSINEA1R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00424">
        <property type="entry name" value="ADENOSINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11 15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="26"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU201114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="329" mass="37269" checksum="30BFD873589827D1" modified="2020-06-17" version="1">MPHHISGFQAAYITIEVLIALVSIPGNILVIWAVKVNQALRDATFYFIVSLAVADVAVGALVIPLAIIINIGPQIHFYSCLMVACPVLILTESSILALLAIAVDRYLRVKIPMRYKSVVTPKRAGIAIACCWLVSLLVGLTPMFGWNNLNEMQKRANASQLTNTSQSEFTVSCQFENVISMEYMVYFNFFVWVLPPLLIMLIIYLEVFKIIRKQLNKKVASCSTDPEKYYGKELQIAKSLALVLFLFAVSWLPLHTLNCISFFYPSCKTHSSLTYIAIFLTHGNSAMNPIVYAFRIRKFRTTFLQIWNHYFYCKGDKHMNNIDNTDIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I193</accession>
    <name>A0A670I193_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RNF6</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNF12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028582199.1">
        <property type="nucleotide sequence ID" value="XM_028726366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I193"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006077.1">
        <property type="protein sequence ID" value="ENSPMRP00000005713.1"/>
        <property type="gene ID" value="ENSPMRG00000003878.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595744"/>
    <dbReference type="KEGG" id="pmua:114595744"/>
    <dbReference type="CTD" id="6049"/>
    <dbReference type="GeneTree" id="ENSGT00940000158530"/>
    <dbReference type="OMA" id="ESHEDNG"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030517">
        <property type="term" value="P:negative regulation of axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044314">
        <property type="term" value="P:protein K27-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060765">
        <property type="term" value="P:regulation of androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000054">
        <property type="entry name" value="E3 ubiquitin-protein ligase RLIM isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058896">
        <property type="entry name" value="RNF6/12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25914">
        <property type="entry name" value="RNF6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="879"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="925" mass="103184" checksum="6F2B0A9B33BDBB7C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1G8</accession>
    <name>A0A670I1G8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Steroid 17-alpha-hydroxylase/17,20 lyase</fullName>
            <ecNumber evidence="5">1.14.14.19</ecNumber>
            <ecNumber evidence="4">1.14.14.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">CYPXVII</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P450 17A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytochrome P450-C17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CYP17A1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADRM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591220.1">
        <property type="nucleotide sequence ID" value="XM_028735387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I301"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006632.1">
        <property type="protein sequence ID" value="ENSPMRP00000006234.1"/>
        <property type="gene ID" value="ENSPMRG00000004214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599717"/>
    <dbReference type="KEGG" id="pmua:114599717"/>
    <dbReference type="CTD" id="11047"/>
    <dbReference type="GeneTree" id="ENSGT00390000013839"/>
    <dbReference type="OMA" id="SNQRHFF"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2020.20:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="9">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="8">
        <location>
            <begin position="280"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="193"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="409" mass="42486" checksum="70351CCDF4854794" modified="2020-06-17" version="1">MSSGALFPSLVPGSRGSSSKYLVEFRAGKMSLKGSTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCTTGRVYVLKFKAGSKRLFFWMQEPKTEKDEEHCRKVNEYLNNPPMPGALGGSGSGGHELSALGGEGGLQSLLGNMSHNQLMQLIGPTGLGGLGGLGALTGPGLASLLGSGGPPTSSSSSSSRSQSAAVTPSSSTSSTRVTPAPTAPAAASATATATSPSPAPSSGNGTSTATSPTQPIQLSDLQTILATMNVPAGAGGQQVDLSSVLTPEIMAPILANTEVQERLLPYLPSGESLPQTAEEIQNTLTSPQFQQALSMFSAALASGQLGPLMSQFGLPAEAVDAANKGDVEAFAKAMQNNVKSDQKEGDSKDKKDEEEDMSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3J2</accession>
    <name>A0A670I3J2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Coiled-coil domain containing 88A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CCDC88A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCDC88 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000006408.1">
        <property type="protein sequence ID" value="ENSPMRP00000006025.1"/>
        <property type="gene ID" value="ENSPMRG00000002867.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155559"/>
    <dbReference type="OMA" id="XEEKTEQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005158">
        <property type="term" value="F:insulin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043422">
        <property type="term" value="F:protein kinase B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043184">
        <property type="term" value="F:vascular endothelial growth factor receptor 2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072660">
        <property type="term" value="P:maintenance of protein location in plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903566">
        <property type="term" value="P:positive regulation of protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22229">
        <property type="entry name" value="HkD_Girdin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000035">
        <property type="entry name" value="girdin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF30">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
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        <text evidence="2">Belongs to the nesprin family.</text>
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        <property type="term" value="P:regulation of cilium assembly"/>
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        <property type="entry name" value="CH_SYNE2_rpt2"/>
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        <property type="entry name" value="SPEC"/>
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        <property type="entry name" value="Nesprin-1 isoform 1"/>
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        <property type="entry name" value="nesprin-1 isoform X4"/>
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        <property type="entry name" value="nesprin-2 isoform X2"/>
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        <property type="entry name" value="Spectrin repeat containing, nuclear envelope 1a"/>
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        <property type="entry name" value="Spectrin repeat-containing, nuclear envelope 2"/>
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        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Actinin_actin-bd_CS"/>
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        <property type="entry name" value="Spectrin/alpha-actinin"/>
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        <property type="entry name" value="Spectrin_repeat"/>
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        <property type="entry name" value="Spectrin_SYNE1"/>
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        <property type="entry name" value="SYNE1/2_dom"/>
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        <property type="entry name" value="NESPRIN-2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR14514">
        <property type="entry name" value="PKA ANCHORING PROTEIN"/>
        <property type="match status" value="1"/>
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    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
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            <begin position="5604"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00046312"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="5686" mass="652096" checksum="5309F98C0646DF1B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IAG1</accession>
    <name>A0A670IAG1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Kalirin</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Protein Duo</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="primary">KALRN</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="37" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009242.1">
        <property type="protein sequence ID" value="ENSPMRP00000008648.1"/>
        <property type="gene ID" value="ENSPMRG00000003634.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155248"/>
    <dbReference type="OMA" id="AKXFIMA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50003"/>
        </source>
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            <dbReference type="PROSITE" id="PS50010"/>
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        <source>
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        </source>
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        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="3004" mass="341846" checksum="57C748D6BBD426AD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICC4</accession>
    <name>A0A670ICC4_PODMU</name>
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            <fullName evidence="1">Chromosome 6 open reading frame 62</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="primary">C6orf62</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="230" mass="27112" checksum="2CC33DA47A51BADC" modified="2020-06-17" version="1">MGDPNSRKKQALNRLRAQLKKKKESLADQFDFKMYIAFVFKDKRKKSALFEVSEVIPVMTNNYEENILKGVQDSSYSLESSIELLQKDVVQLHAPRYQSMRRDVIGCTQEMDFILWPRNDIEKIVCLLFSRWKGSDDEPFRPVQARFEFHHGDYEKQFLHVLSRKDKTGIVINNPNQSVFLFIDRQHLQTPKNKATIFKLCSICLYLPQEQLTHWAVGTVEDHLRPYMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICK7</accession>
    <name>A0A670ICK7_PODMU</name>
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        <submittedName>
            <fullName evidence="16">HtrA serine peptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HTRA1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028585871.1">
        <property type="nucleotide sequence ID" value="XM_028730038.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000009970.1">
        <property type="protein sequence ID" value="ENSPMRP00000009342.1"/>
        <property type="gene ID" value="ENSPMRG00000006287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597418"/>
    <dbReference type="KEGG" id="pmua:114597418"/>
    <dbReference type="CTD" id="5654"/>
    <dbReference type="GeneTree" id="ENSGT00940000156955"/>
    <dbReference type="OMA" id="PAECAGS"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="cpPDZ_HtrA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.120:FF:000002">
        <property type="entry name" value="HtrA serine peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000142">
        <property type="entry name" value="Serine protease HTRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017891">
        <property type="entry name" value="Insulin_GF-bd_Cys-rich_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF13">
        <property type="entry name" value="SERINE PROTEASE HTRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00222">
        <property type="entry name" value="IGFBP_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
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    <keyword evidence="11" id="KW-0340">Growth factor binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="15">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
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        <location>
            <begin position="370"/>
            <end position="471"/>
        </location>
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    </evidence>
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    <sequence length="485" mass="51796" checksum="BFDA33BCB2930536" modified="2020-06-17" version="1">MRGALWPLALSFFCLLPPPGCRAQLYGRRFEERPCPERCERARCPELPPECAGSGESLDPCGCCPVCAAQEGEPCGGPPAGEPSCAEGLLCVVSPGGPGVAASATVRRRAKGGRCVCASSEPVCGNDGRSYGNVCQLRAASRLSEGQRQPAVIAIQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGETREAKIKDIDEKADIALIKIDTAGKLPVLLLGRSGELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAVTKKKYIGIRMMSLTPSKAKELKERHKDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQPILSANDVSDIIKKDNTLSLVVRRGNEDIILTVIPDEIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICN4</accession>
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        <submittedName>
            <fullName evidence="8">UTP6 small subunit processome component</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">UTP6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
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        <property type="gene ID" value="ENSPMRG00000006206.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF24892"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="582" mass="68272" checksum="DE0D20A70D68A472" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEX3</accession>
    <name>A0A670IEX3_PODMU</name>
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        <submittedName>
            <fullName evidence="3">Family with sequence similarity 43 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM43A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028587791.1">
        <property type="nucleotide sequence ID" value="XM_028731958.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000010983.1">
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        <property type="gene ID" value="ENSPMRG00000006860.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114598210"/>
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    <dbReference type="OMA" id="AMHLECG"/>
    <dbReference type="OrthoDB" id="5962185at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01214">
        <property type="entry name" value="PTB_FAM43A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF36">
        <property type="entry name" value="PROTEIN FAM43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00462">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="460" mass="48669" checksum="E84D9B03D597FAD9" modified="2020-06-17" version="1">MRGRPGLRRAPPAEEQQQQRPGPAAPSGGDAMLPWKRHKFELLAVDDEQLTQQQQQHKKTQQKHRRHPPPPSPPPPPPSAPSGKGKGSCCAAGAGSLPCSAALGSLARACPPEGALSRMGNLFRCKRKKFRVSSEAPTYTVLYLGNATTLQAKGEGCTDVAVGKIWAKSEAGRHGTKMKLTIGPQGIRMAPAAPSEAASRPGHLYLLHRVTYCVADPRLPRLFAWIYRHEVKHKAVLLRCHAVLVSKAEKARAMALLLYQTSAAALAEFRRLKKRADARHQQLQQAGAAAADGAIPLVPLRKLLLHGPGCCYKPPVERSRSAPKLGSITEDALGEELEERAAGLRAGGLANGGGPDGEDEEEGDCDDDELLAPLGEDDDEDDGADAAPSLGQLICDLGELAIGNDVALLRADLRVTRLLSGESTGSESSIESNGHDGGSPPPPLQPCRGPDSPEPGGDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IF27</accession>
    <name>A0A670IF27_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Programmed cell death 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PDCD10</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PDCD10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587308.1">
        <property type="nucleotide sequence ID" value="XM_028731475.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028587309.1">
        <property type="nucleotide sequence ID" value="XM_028731476.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028587310.1">
        <property type="nucleotide sequence ID" value="XM_028731477.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028587311.1">
        <property type="nucleotide sequence ID" value="XM_028731478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IF27"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011019.1">
        <property type="protein sequence ID" value="ENSPMRP00000010346.1"/>
        <property type="gene ID" value="ENSPMRG00000006879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597949"/>
    <dbReference type="KEGG" id="pmua:114597949"/>
    <dbReference type="CTD" id="11235"/>
    <dbReference type="GeneTree" id="ENSGT00390000017913"/>
    <dbReference type="OMA" id="HVVLFPI"/>
    <dbReference type="OrthoDB" id="6017654at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051683">
        <property type="term" value="P:establishment of Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090168">
        <property type="term" value="P:Golgi reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036481">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903588">
        <property type="term" value="P:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090051">
        <property type="term" value="P:negative regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090316">
        <property type="term" value="P:positive regulation of intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044319">
        <property type="term" value="P:wound healing, spreading of cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.70:FF:000001">
        <property type="entry name" value="Programmed cell death protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.330:FF:000006">
        <property type="entry name" value="Programmed cell death protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009652">
        <property type="entry name" value="PDCD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13250:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13250">
        <property type="entry name" value="TF-1 CELL APOPTOSIS RELATED PROTEIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06840">
        <property type="entry name" value="PDC10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 10 dimerisation" evidence="11">
        <location>
            <begin position="15"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="212" mass="24698" checksum="EEA617B74EEBBC3B" modified="2020-06-17" version="1">MRMTMEEMKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIIKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRLIHQTNLILQTFKTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IG24</accession>
    <name>A0A670IG24_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Developing brain homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DBX1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the H2.0 homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IG24"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011010.1">
        <property type="protein sequence ID" value="ENSPMRP00000010337.1"/>
        <property type="gene ID" value="ENSPMRG00000006874.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183093"/>
    <dbReference type="OMA" id="RHSLAYH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021521">
        <property type="term" value="P:ventral spinal cord interneuron specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000177">
        <property type="entry name" value="Homeobox protein DBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051662">
        <property type="entry name" value="H2.0_Homeobox_NeuralPatt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24331">
        <property type="entry name" value="DBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24331:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN DBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="187"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="341" mass="37073" checksum="855BD51131F2E246" modified="2020-06-17" version="1">MMFPSLIAPPAVYPSLLRPTPTLTLPQSLQSAFSGHSSFLVEDLIRISRPAAYLPRGGGVPPPASLSPPPLSGASPSRTGPPGPSSAEPANSDGAARRGCSAPASASPASDAPFLKFGVHAILSSAPRTETSHALMQNVPPKTFTFPYFEGSFQPFIRSSYFPASSVVPIPGTFSWPLAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNRRMKWRNSKERELLSSGGCREQTLPTKFNPHPDLSDVGKKGSGEEEEEAASPRCPASPRHSLTYHQSTDDPRLRDSSLAISLFCDCCRCNVWMRGTGPASLIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGQ0</accession>
    <name>A0A670IGQ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IGQ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011220.1">
        <property type="protein sequence ID" value="ENSPMRP00000010517.1"/>
        <property type="gene ID" value="ENSPMRG00000006991.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159769"/>
    <dbReference type="OMA" id="SITCFEP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000001">
        <property type="entry name" value="calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcium/calmodulin-dependent protein kinase II association-domain" evidence="2">
        <location>
            <begin position="56"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="202" mass="22934" checksum="E3242654156AADE2" modified="2020-06-17" version="1">MLLVLSVLTLIPCLFLLTWYFFSTGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYVDTSGIPRTAQSEETRIWHRRDGKWQIVHFHRSGAPSVLPQREHSNTQAPTCTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHG3</accession>
    <name>A0A670IHG3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Growth arrest specific 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GAS2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IHG3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011508.1">
        <property type="protein sequence ID" value="ENSPMRP00000010787.1"/>
        <property type="gene ID" value="ENSPMRG00000007170.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155755"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001547">
        <property type="term" value="P:antral ovarian follicle growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071711">
        <property type="term" value="P:basement membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001544">
        <property type="term" value="P:initiation of primordial ovarian follicle growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030728">
        <property type="term" value="P:ovulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.20:FF:000003">
        <property type="entry name" value="Growth arrest-specific 2 like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF9">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="327" mass="36595" checksum="6219F344038B441B" modified="2020-06-17" version="1">MKCRKSVSGEGKKKVSQREHQVEREIRSMKSGSSAAAAGLLRRGKQDGLQRKSFGASRTERKEITAETFMEKLDNGALLCRLAETLQEKFKENCIEVNKIGKIMPVRRIPCKANAPPGSFFARDNTANFLSWCRDVGVDDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGVEPPGLIKLEKEIEQEETLSTPLPSPSPSPSKSPGKKSTGKLLDDAVKHISEDPPCKCPSKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPIQNKSPTIKDMNPDSYLVVSAHYKTKKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJ63</accession>
    <name>A0A670IJ63_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neuroligin 4 X-linked</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NLGN4X</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583571.1">
        <property type="nucleotide sequence ID" value="XM_028727738.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583572.1">
        <property type="nucleotide sequence ID" value="XM_028727739.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583573.1">
        <property type="nucleotide sequence ID" value="XM_028727740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IJ63"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012461.1">
        <property type="protein sequence ID" value="ENSPMRP00000011664.1"/>
        <property type="gene ID" value="ENSPMRG00000007813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596312"/>
    <dbReference type="KEGG" id="pmua:114596312"/>
    <dbReference type="CTD" id="57502"/>
    <dbReference type="GeneTree" id="ENSGT00940000156607"/>
    <dbReference type="OMA" id="HQQHMQN"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000001">
        <property type="entry name" value="Neuroligin 3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000460">
        <property type="entry name" value="Nlgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01090">
        <property type="entry name" value="NEUROLIGIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="15">
        <location>
            <begin position="45"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="638"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="835" mass="93813" checksum="271795C6A798BE79" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJM8</accession>
    <name>A0A670IJM8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Matrix metallopeptidase 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MMP24</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="18">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IJM8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012605.1">
        <property type="protein sequence ID" value="ENSPMRP00000011801.1"/>
        <property type="gene ID" value="ENSPMRG00000007849.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158315"/>
    <dbReference type="OMA" id="AMTQHYY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098742">
        <property type="term" value="P:cell-cell adhesion via plasma-membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050965">
        <property type="term" value="P:detection of temperature stimulus involved in sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097150">
        <property type="term" value="P:neuronal stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000005">
        <property type="entry name" value="Matrix metallopeptidase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000001">
        <property type="entry name" value="Matrix metallopeptidase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021805">
        <property type="entry name" value="Pept_M10A_metallopeptidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF138">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11857">
        <property type="entry name" value="DUF3377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="23">
        <location>
            <begin position="146"/>
            <end position="315"/>
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        <location>
            <begin position="364"/>
            <end position="412"/>
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    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="413"/>
            <end position="458"/>
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    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="460"/>
            <end position="508"/>
        </location>
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    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="509"/>
            <end position="556"/>
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    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="310"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="316"/>
            <end position="328"/>
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    <feature type="active site" evidence="17">
        <location>
            <position position="270"/>
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    </feature>
    <feature type="binding site" description="in inhibited form" evidence="18">
        <location>
            <position position="126"/>
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        <ligand>
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            <position position="206"/>
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        <location>
            <position position="231"/>
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    </feature>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="466"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="19">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="632" mass="73094" checksum="5F4B8FBEEE8F59F3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IL30</accession>
    <name>A0A670IL30_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Di-N-acetylchitobiase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CTBS</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IL30"/>
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        <property type="protein sequence ID" value="ENSPMRP00000012294.1"/>
        <property type="gene ID" value="ENSPMRG00000008223.1"/>
    </dbReference>
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    <dbReference type="OMA" id="CKPISTQ"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000006">
        <property type="entry name" value="Chitobiase, di-N-acetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000250">
        <property type="entry name" value="Probable di-N-acetylchitobiase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051887">
        <property type="entry name" value="GH18_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
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        <property type="entry name" value="DI-N-ACETYLCHITOBIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DI-N-ACETYLCHITOBIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
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    </dbReference>
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        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="389" mass="43952" checksum="C3823AB99DC4F0FB" modified="2020-06-17" version="1">GALIKPFPQRHPLHFWAEPASHFPPRQPSARHYIFSKRQRRKGAAAAARTHLRTHHAPLKHLIRRHGGVAKRRRRAPPGRAPPPHLPPASELRRVPVRGPRALQPHLRSQGLRGDISVKSIVDPAVRAAWIKEKVDLAKRQHLDGINIDIEQEVAKSSPEYYALTDLVKETTEAFHREIPGSQVTFDVAWSPDCIDKRCYNYTGIAESCDFVFVMSYDEQSQVWSECIARANAPYNHTIMEYEKYIHMGINPKKIVMGVPWYGYDYTCLGLIKAHVCSIAKVPFRGAPCSDAAGRQRPYKVIMDLVNSSISGILWDEEQEAPYLEYKDGHGVFHQVWFDNPRSISLKAAYVKKLGLRGIGMWNADCLNYSGGSLAQEQTAAMWAALIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IL81</accession>
    <name>A0A670IL81_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polypeptide N-acetylgalactosaminyltransferase 13</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IL81"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013617.1">
        <property type="protein sequence ID" value="ENSPMRP00000012750.1"/>
        <property type="gene ID" value="ENSPMRG00000008525.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158904"/>
    <dbReference type="OMA" id="RRESTCV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.460:FF:000001">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000014">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000195">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.460">
        <property type="entry name" value="ppGaNTase-T1 linker domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF47">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="4">
        <location>
            <begin position="180"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="324" mass="37620" checksum="B98D1CCD62A8FCDE" modified="2020-06-17" version="1">MAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKALRENLKCKPFSWYLENVYPDSQIPRRYYSLGEIRNVETNQCLDNMGRKENEKVGIFNCHGMGGNQVFSYTADKEIRTDDLCLDVSRLNGPVIMLKCHHMRGNQLWEYDAETHTFLHIITQSCLTISRIEDGTRGPTVETCNGSPFQKWLLRNYTRLEVFRNIFYSPTDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IM32</accession>
    <name>A0A670IM32_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ATP6V0D1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028595310.1">
        <property type="nucleotide sequence ID" value="XM_028739477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IM32"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013613.1">
        <property type="protein sequence ID" value="ENSPMRP00000012746.1"/>
        <property type="gene ID" value="ENSPMRG00000008521.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601879"/>
    <dbReference type="KEGG" id="pmua:114601879"/>
    <dbReference type="CTD" id="9114"/>
    <dbReference type="GeneTree" id="ENSGT00390000002200"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036295">
        <property type="term" value="P:cellular response to increased oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012746.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="353" mass="40418" checksum="679724A1DA8EA80A" modified="2020-06-17" version="1">MLLSCFPELYFNVDSGYLEGLVRGFKAGVLSQADYVNLVQCESLEDLKLHLQSTDYGNFLANEASPLTVSVIDDKLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCKILGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGKLYPEGLAQLARADDYEQVKAVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IN34</accession>
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        </recommendedName>
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        </alternativeName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Promotes cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IN34"/>
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        <property type="gene ID" value="ENSPMRG00000008909.1"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:focal adhesion"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of stress fiber assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
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    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043593">
        <property type="entry name" value="ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028775">
        <property type="entry name" value="BAR_ASAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854:SF1">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="310"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="18">
        <location>
            <begin position="433"/>
            <end position="555"/>
        </location>
    </feature>
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        <location>
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            <end position="628"/>
        </location>
    </feature>
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        <location>
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            <end position="661"/>
        </location>
    </feature>
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            <end position="314"/>
        </location>
    </feature>
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            <end position="742"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="853"/>
            <end position="949"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
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            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
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            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="865"/>
            <end position="904"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00054302"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072373"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1052" mass="116521" checksum="577E731540813D0C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IN60</accession>
    <name>A0A670IN60_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead box A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FOXA3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="7 8" key="1">
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028597943.1">
        <property type="nucleotide sequence ID" value="XM_028742110.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A670IN60"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013593.1">
        <property type="protein sequence ID" value="ENSPMRP00000012727.1"/>
        <property type="gene ID" value="ENSPMRG00000008509.1"/>
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    <dbReference type="GeneID" id="114603254"/>
    <dbReference type="KEGG" id="pmua:114603254"/>
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    <dbReference type="GeneTree" id="ENSGT00940000166203"/>
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    <dbReference type="OrthoDB" id="5954824at2759"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein domain specific binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell differentiation"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd20040">
        <property type="entry name" value="FH_FOXA3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="hepatocyte nuclear factor 3-beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="FH_FOXA3"/>
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        <property type="entry name" value="Fork_head_dom"/>
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        <property type="entry name" value="Forkhead_box_C"/>
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        <property type="entry name" value="FOX_domain-containing"/>
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        <property type="entry name" value="TF_fork_head_CS_1"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF201">
        <property type="entry name" value="HEPATOCYTE NUCLEAR FACTOR 3-GAMMA"/>
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        <property type="entry name" value="HNF_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
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        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="145"/>
            <end position="239"/>
        </location>
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            <begin position="145"/>
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            <begin position="252"/>
            <end position="261"/>
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            <begin position="282"/>
            <end position="295"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012727.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="419" mass="46083" checksum="346DC5154CDBA602" modified="2020-06-17" version="1">MLGSVKMESHDISEWTSYYNEPTEVFPSVSTMTSSLGPMNSINSYVTLNPLTSPSSMNMPYPNSGLSSPSLTGLTNATSSMGLPSVASPVSPVLTQLGAQAPTLNSLSPYQNVGQSMAPLSYSPSGMNRPKEINKSYRRTLTHAKPPYSYISLITMAIQQAPSKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPNSGNMFENGCYLRRQKRFKIEDKAKKPNSKGSNAQEQASKMPEGLQEGQSPNTGSEGAESGHSDTSHGSEEQRGLVQLDCSGGQGSSPVSEASPAPISQSMNSHYFATSITNLDLPSDLKMDPQFNFNHPFSITNLMSTEQNHKIDLKSYEQAMAYSGYSSPHAVESKHPYEASTSLSETGSYYQNLYSRSLLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INP5</accession>
    <name>A0A670INP5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MARCHF7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670INP5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014040.1">
        <property type="protein sequence ID" value="ENSPMRP00000013154.1"/>
        <property type="gene ID" value="ENSPMRG00000008793.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063836"/>
    <dbReference type="OMA" id="RMMSGNR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097371">
        <property type="term" value="F:MDM2/MDM4 family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043518">
        <property type="term" value="P:negative regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902166">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901799">
        <property type="term" value="P:negative regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905524">
        <property type="term" value="P:negative regulation of protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902916">
        <property type="term" value="P:positive regulation of protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002643">
        <property type="term" value="P:regulation of tolerance induction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052297">
        <property type="entry name" value="RING-CH-type_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471">
        <property type="entry name" value="MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="593"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="777" mass="85897" checksum="1F7258F13B7F7B09" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IP00</accession>
    <name>A0A670IP00_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CNF-like-inhibitor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IP00"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014666.1">
        <property type="protein sequence ID" value="ENSPMRP00000013725.1"/>
        <property type="gene ID" value="ENSPMRG00000009203.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163304"/>
    <dbReference type="OMA" id="CANELAC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019834">
        <property type="term" value="F:phospholipase A2 inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="TFP_LU_ECD_PINLYP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFP_LU_ECD_PLIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CNF-like_PLA2_Inhibitor"/>
    </dbReference>
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        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
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        <property type="entry name" value="PLipase_A2_inh_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914">
        <property type="entry name" value="LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914:SF30">
        <property type="entry name" value="LY6_PLAUR DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02988">
        <property type="entry name" value="PLA2_inh"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Snake toxin-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0593">Phospholipase A2 inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="UPAR/Ly6" evidence="6">
        <location>
            <begin position="116"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="317" mass="33740" checksum="CB53CD188570CBA3" modified="2020-06-17" version="1">MNIKANREGCMVLYMRPPVCKVDLLPTWPVSHWGGALASPPCFPGSLTDLFYRTVPHLPTTHTHIRSCIKEAEVWVGFVLCVCSRLVNSSQLKSRMMQTPLFISLLAAFIALGMALECEQCTGPTSRCSGPMMQCTQEQDTCVSRVLSVSISGIDQNVFEKGCGSSKLCGKGPQIINSGLFGTTVIETHCCVGAACKTTWPPTPRRNTTLNGRQCSTCPPDGTECKFPPIKCAGEETKCFEISGATTIAGQTASTVLKGCANELACQAMEIGTKTFGNVIQEVKSAKCTDGAASTIPGSLGLLFPALSGLLLVKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IP44</accession>
    <name>A0A670IP44_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxysteroid dehydrogenase like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HSDL1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028595378.1">
        <property type="nucleotide sequence ID" value="XM_028739545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IP44"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014195.1">
        <property type="protein sequence ID" value="ENSPMRP00000013294.1"/>
        <property type="gene ID" value="ENSPMRG00000008897.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601910"/>
    <dbReference type="KEGG" id="pmua:114601910"/>
    <dbReference type="CTD" id="83693"/>
    <dbReference type="GeneTree" id="ENSGT00950000185010"/>
    <dbReference type="OMA" id="QYGLMKC"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052149">
        <property type="entry name" value="17-beta-HSD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889:SF1">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="320" mass="35532" checksum="68CBD989EAE5D665" modified="2020-06-17" version="1">MAAVDSFSFLLREIGQACSCVIETLAFIGAFYIMKTSLTVASNTYSLIRLYFIPRLVSRPDLVKLYGRWAAVTGCTSGIGKSYAKELACHGVNVVLISRNKEMLEALAKDIEDSYKVETEVVVADFSRGRQVYPAIKKALLGKETGILVNNVGVFYDHPDYFANLTEDKIWDLININIGAANMMVHMVLPGMVQRKKGAIVNVSSMSSYHPSPRMTAYSASKAYLDHFSQSLYYEYAPQGIFVQCLCPAFVCTNMSKYSPTLSKKSLLVPSADEYAHQAIATLGLSRRTPGYSLHSIQGFFAQIIPEWLWVRGMSRLGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IPM2</accession>
    <name>A0A670IPM2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    <sequence length="1311" mass="148769" checksum="B1D557986376A65D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRZ9</accession>
    <name>A0A670IRZ9_PODMU</name>
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            <fullName evidence="19">Ephrin type-A receptor 6</fullName>
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            <fullName evidence="20">EPH homology kinase 2</fullName>
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        <name evidence="30" type="primary">EPHA6</name>
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    <organism evidence="30 31">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
            </authorList>
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    <comment type="function">
        <text evidence="17">Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (via SAM domain) with ANKS1A (via SAM domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:axon guidance"/>
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        <property type="entry name" value="ephrin a2 ectodomain"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="Tyr_kinase_AS"/>
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    <dbReference type="InterPro" id="IPR020635">
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    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF10">
        <property type="entry name" value="EPHRIN TYPE-A RECEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibronectin type III"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00791">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 22 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 22 24" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="14" id="KW-0675">Receptor</keyword>
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            <begin position="606"/>
            <end position="631"/>
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            <end position="272"/>
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            <end position="499"/>
        </location>
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        <location>
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            <end position="595"/>
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        <location>
            <begin position="689"/>
            <end position="1002"/>
        </location>
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        <location>
            <begin position="1023"/>
            <end position="1083"/>
        </location>
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        <location>
            <position position="856"/>
        </location>
    </feature>
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        <location>
            <begin position="695"/>
            <end position="703"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="721"/>
        </location>
        <ligand>
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        </ligand>
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            <begin position="136"/>
            <end position="254"/>
        </location>
    </feature>
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            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51550"/>
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    </evidence>
    <sequence length="1094" mass="122109" checksum="A12C18E4EFE8DA90" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITL2</accession>
    <name>A0A670ITL2_PODMU</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ITL2"/>
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        <property type="gene ID" value="ENSPMRG00000009683.1"/>
    </dbReference>
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    <dbReference type="OMA" id="LGEWYAE"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="129"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14081" checksum="1DD6984210136344" modified="2020-06-17" version="1">RCVVAGEVAALVLVAVLWGGTNPFLKRGTEGLERVKRESRTLQLLAEIKFLCLNYKYVVPFVLNQCGSFVYYLTLGSTDLTLAVPLCNSLALMFTLATGKVLGEDIGGATALGMLLTALGVALCIAGSVHETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITX7</accession>
    <name>A0A670ITX7_PODMU</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="6" type="primary">LOC114593730</name>
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    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028578210.1">
        <property type="nucleotide sequence ID" value="XM_028722377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ITX7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016717.1">
        <property type="protein sequence ID" value="ENSPMRP00000015653.1"/>
        <property type="gene ID" value="ENSPMRG00000010454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593730"/>
    <dbReference type="KEGG" id="pmua:114593730"/>
    <dbReference type="GeneTree" id="ENSGT00940000161750"/>
    <dbReference type="OMA" id="DMIMILP"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03208">
        <property type="entry name" value="GST_C_Alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000005">
        <property type="entry name" value="Glutathione S-transferase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003080">
        <property type="entry name" value="GST_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF107">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01266">
        <property type="entry name" value="GSTRNSFRASEA"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="222" mass="25731" checksum="B2BB321FB5F5179C" modified="2020-06-17" version="1">MAGKPKLHYVRGRGKMESIRWLLAAAGVEFEEQFIETNEDLEKLRKNGQLLFQQVPMVEIDGMKMVQTRAILNYIAAKHNLYGKDLKERALIDMYVEGTTDLMGMIMSLPFQPPENKEKQTSLIFERATTRYFPVYEKVLKDHGQDFLVGGKFSWADVHLLEAILMVEEMKPDVLSAFPLLQAFKTRVSNIPTIKKFLQPGSQRKPPFDEKYIVQIRKIFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVE4</accession>
    <name>A0A670IVE4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IVE4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016978.1">
        <property type="protein sequence ID" value="ENSPMRP00000015900.1"/>
        <property type="gene ID" value="ENSPMRG00000010627.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166838"/>
    <dbReference type="OMA" id="THIVKIQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="344"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="892"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1192"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1231" mass="137604" checksum="4DA25C6E65CC3B97" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IW90</accession>
    <name>A0A670IW90_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">A-type voltage-gated potassium channel KCND2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Potassium voltage-gated channel subfamily D member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Voltage-gated potassium channel subunit Kv4.2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">KCND2</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IW90"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016466.1">
        <property type="protein sequence ID" value="ENSPMRP00000015417.1"/>
        <property type="gene ID" value="ENSPMRG00000010278.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155472"/>
    <dbReference type="OMA" id="MWRAFES"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071193">
        <property type="term" value="C:Kv4.2-KChIP2 channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905030">
        <property type="term" value="F:voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045475">
        <property type="term" value="P:locomotor rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086009">
        <property type="term" value="P:membrane repolarization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019233">
        <property type="term" value="P:sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000073">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000016">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000004">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004055">
        <property type="entry name" value="K_chnl_volt-dep_Kv4.2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021645">
        <property type="entry name" value="Shal-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF265">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11601">
        <property type="entry name" value="Shal-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01517">
        <property type="entry name" value="KV42CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="24" id="KW-0407">Ion channel</keyword>
    <keyword evidence="20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="21 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="17" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="31" id="KW-0732">Signal</keyword>
    <keyword evidence="19" id="KW-0770">Synapse</keyword>
    <keyword evidence="11 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 30" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0851">Voltage-gated channel</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="31">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025604843" description="A-type voltage-gated potassium channel KCND2" evidence="31">
        <location>
            <begin position="17"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="32">
        <location>
            <begin position="41"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00044992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00045011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="434" mass="49240" checksum="7299C63E1E488637" modified="2020-06-17" version="1">MAAGVAAWLPFARAAAIGWMPVATNPMPTAPRQERKRSQDSLIVLNVSGTQFQTWLDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRQECISAYDEELAFFGIIPEIIGDCCYEEYKDRRRENAERLQDDADQDNADECNLPSMTARERMWRAFENPHTSTLALVFYYVTGFFIAVSVLANVVETVPCGLSPGTIKELSCGERYDVAFFCLDTACVMIFTVEYLLRLVAAPSRYKFVRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSTSTKFTSIPAAFWYTIVTMTTLGISLGKWCHGQDRVTARREVEDRRGETTLRILWPSLLSREGTFVAALPKAGLSACGTLLLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWJ8</accession>
    <name>A0A670IWJ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein 366</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dendritic cell-specific transcript protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF366</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Has transcriptional repression activity. Acts as a corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with ESR1 and NRIP1. Interacts (via PXDLS motif) with CTBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028604952.1">
        <property type="nucleotide sequence ID" value="XM_028749119.1"/>
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    <dbReference type="Ensembl" id="ENSPMRT00000017434.1">
        <property type="protein sequence ID" value="ENSPMRP00000016335.1"/>
        <property type="gene ID" value="ENSPMRG00000010901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606661"/>
    <dbReference type="KEGG" id="pmua:114606661"/>
    <dbReference type="CTD" id="167465"/>
    <dbReference type="GeneTree" id="ENSGT00940000155498"/>
    <dbReference type="OMA" id="FKHRNKS"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033147">
        <property type="term" value="P:negative regulation of intracellular estrogen receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043627">
        <property type="term" value="P:response to estrogen"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000161">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000182">
        <property type="entry name" value="zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000186">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000191">
        <property type="entry name" value="zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000203">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001180">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001304">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001574">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001721">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000502">
        <property type="entry name" value="Zinc finger protein 710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="274"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="302"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="414"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
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    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="498"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="526"/>
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        </location>
    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="550"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068071"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="731" mass="84166" checksum="B0253A3070AAF99A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXT0</accession>
    <name>A0A670IXT0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glial fibrillary acidic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GFAP</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
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    </dbReference>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:astrocyte end-foot"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014002">
        <property type="term" value="P:astrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060020">
        <property type="term" value="P:Bergmann glial cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070779">
        <property type="term" value="P:D-aspartate import across plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060291">
        <property type="term" value="P:long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031102">
        <property type="term" value="P:neuron projection regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010625">
        <property type="term" value="P:positive regulation of Schwann cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904714">
        <property type="term" value="P:regulation of chaperone-mediated autophagy"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051580">
        <property type="term" value="P:regulation of neurotransmitter uptake"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014010">
        <property type="term" value="P:Schwann cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006821">
        <property type="entry name" value="Intermed_filament_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050405">
        <property type="entry name" value="Intermediate_filament"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652">
        <property type="entry name" value="GLIAL FIBRILLARY ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652:SF9">
        <property type="entry name" value="GLIAL FIBRILLARY ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04732">
        <property type="entry name" value="Filament_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="83"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="87"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="403" mass="47245" checksum="F6E17F975FC2812D" modified="2020-06-17" version="1">MEGQRLSSYGRRFGAQTSSIHHALRFSPGRRYLSSGAGTRLSVTKLKTSSLSFRAGPKFSPDKVDFSLADALNTEFKETRTNEKVEMMELNDRFASYIEKVRFLEQQNKVLVAELNQIRDKEPTKLADIYQEEVRELRHQVDQLTNSKARLEIERDNLLEDLNNLRQKLQDEINQRLEAENNLSSYRQDVDDAALARIDLERKIESLQEEINFLKKIHEEELRELQEQLQQQQVHIEMDMAKPDLTSALREIRIQYESMASNNMHETEEWYKSKFADLTDAAARNIEALRLAKQEANEYRRQLQSLTCDLESLRGSVGGVDVEIWRTVRWLLRPIKRDERRKHSRPQLDLMVRGPFTLYLFILPNIMQFGILFSFTYASVHTLYSYIIFACVTWLENGVAKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IYC6</accession>
    <name>A0A670IYC6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amine oxidase</fullName>
            <ecNumber evidence="8">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114581941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="7">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7 8">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028558503.1">
        <property type="nucleotide sequence ID" value="XM_028702670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IYC6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018108.1">
        <property type="protein sequence ID" value="ENSPMRP00000017000.1"/>
        <property type="gene ID" value="ENSPMRG00000011278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581941"/>
    <dbReference type="KEGG" id="pmua:114581941"/>
    <dbReference type="GeneTree" id="ENSGT00950000183207"/>
    <dbReference type="OMA" id="CMFEIDK"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000002">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000007">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF4">
        <property type="entry name" value="RETINA-SPECIFIC COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0186">Copper</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="10">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="11">
        <location>
            <begin position="163"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="9">
        <location>
            <begin position="307"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="6">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="7">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="758" mass="85741" checksum="20D730F6973BB834" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J0T8</accession>
    <name>A0A670J0T8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ornithine decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ODC1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A670J0T8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018968.1">
        <property type="protein sequence ID" value="ENSPMRP00000017820.1"/>
        <property type="gene ID" value="ENSPMRG00000011766.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182995"/>
    <dbReference type="OMA" id="AYCRSMA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
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        <property type="entry name" value="Ornithine decarboxylase 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF42">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="14">
        <location>
            <begin position="69"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="15">
        <location>
            <begin position="74"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="489" mass="54343" checksum="4E671E63F2B325EE" modified="2020-06-17" version="1">MTGGRTNKLFPMSLQFFTENHFGITTSSKMNDFSGEEFNFSFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDVLKKHLRWYKALPRVSPFYAVKCNDSIALVKTLAALGAGFDCASKTEIQLVQSAGVPPERIIYANPCKQVSQIKHAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLLLERAKELDIDIIGVSFHVGSGCTDPETFVQAISDARCVFDMGVELGFNMYLLDIGGGFPGSEDVKLKFEEITNVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKVVIKEHTGSDDEEEPNDKTLMYYVNDGVYGSFNCILYDHAHVKPVLQKRPKPDERYYSCSIWGPTCDGLDRIVERCSLPELQVGDWMLFENMGAYTVAAASTFNGFQRPTIHYVMSRPAWQLMQRIKEQGFQAEVEEQDVTLPLSCAWESGIEHYPAACASASINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J166</accession>
    <name>A0A670J166_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Chromodomain helicase DNA binding protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CHD5</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000019086.1">
        <property type="protein sequence ID" value="ENSPMRP00000017936.1"/>
        <property type="gene ID" value="ENSPMRG00000009267.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159249"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061628">
        <property type="term" value="F:histone H3K27me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18667">
        <property type="entry name" value="CD1_tandem_CHD3-4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18662">
        <property type="entry name" value="CD2_tandem_CHD3-4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18057">
        <property type="entry name" value="DEXHc_CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15531">
        <property type="entry name" value="PHD1_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000037">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000003">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000001">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000001">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000011">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000015">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012957">
        <property type="entry name" value="CHD_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009462">
        <property type="entry name" value="CHD_II_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012958">
        <property type="entry name" value="CHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028727">
        <property type="entry name" value="DEXHc_CHD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009463">
        <property type="entry name" value="DUF1087"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="326" mass="35591" checksum="ED09B3E50F189A69" modified="2020-06-17" version="1">MHMRSSTPHRRSPREHAQPPSPLRRARSEPLRRPGAYPERRRITASGDEAPPLFLPPPPFLPSHPLRPPSLFFWSVSSQCACGKRRERERRGEKATAREEAGGRGERARGGDKCACALRAGLQQAAAAAAAVELAGGFHNICSTMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILVSEHVGGRRGRGLLLLPASLGPSDLCVWGGVYLFLSPERPGMAKHGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1Y2</accession>
    <name>A0A670J1Y2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A670J1Y2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018678.1">
        <property type="protein sequence ID" value="ENSPMRP00000017544.1"/>
        <property type="gene ID" value="ENSPMRG00000011596.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004215"/>
    <dbReference type="OMA" id="FEGFKMS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF28">
        <property type="entry name" value="CASEIN KINASE 2 ALPHA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="379" mass="43727" checksum="E243C57E70F10517" modified="2020-06-17" version="1">MSGPVPSRARVYADVNTQRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIISLLDIVKDPVSRTPALVFEHVNNTDFKQLYQTLSDFDIRFYMYEILKALDYCHSMGVMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSTEALDFLDKLLRYDHQTRLTAREAMEHPYFYPIVKDPARMGSSTVLSAANMPVTSSSMLAGIASMSASQPIGSLAASPVISSPNTLGSPVPATAGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J541</accession>
    <name>A0A670J541_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exportin 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">XPO7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J541"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019880.1">
        <property type="protein sequence ID" value="ENSPMRP00000018709.1"/>
        <property type="gene ID" value="ENSPMRG00000012274.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000019886.1">
        <property type="protein sequence ID" value="ENSPMRP00000018715.1"/>
        <property type="gene ID" value="ENSPMRG00000012274.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000019899.1">
        <property type="protein sequence ID" value="ENSPMRP00000018728.1"/>
        <property type="gene ID" value="ENSPMRG00000012274.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000019918.1">
        <property type="protein sequence ID" value="ENSPMRP00000018747.1"/>
        <property type="gene ID" value="ENSPMRG00000012274.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000019939.1">
        <property type="protein sequence ID" value="ENSPMRP00000018768.1"/>
        <property type="gene ID" value="ENSPMRG00000012274.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153139"/>
    <dbReference type="OMA" id="DCFHELC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000042">
        <property type="entry name" value="exportin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057947">
        <property type="entry name" value="TPR_XPO7/RBP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF11">
        <property type="entry name" value="EXPORTIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25795">
        <property type="entry name" value="TPR_XPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="999" mass="113401" checksum="D539EA8910CD34EA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J5M9</accession>
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        <submittedName>
            <fullName evidence="20">Regulator of chromosome condensation 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RCC2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J5M9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021054.1">
        <property type="protein sequence ID" value="ENSPMRP00000019823.1"/>
        <property type="gene ID" value="ENSPMRG00000012920.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156151"/>
    <dbReference type="OMA" id="GKWKNTG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072356">
        <property type="term" value="P:chromosome passenger complex localization to kinetochore"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048041">
        <property type="term" value="P:focal adhesion assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:integrin-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="RCC2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000009">
        <property type="entry name" value="Regulator of chromosome condensation 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
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    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
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    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="127"/>
            <end position="519"/>
        </location>
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        <location>
            <begin position="190"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="17">
        <location>
            <begin position="242"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="17">
        <location>
            <begin position="294"/>
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    </feature>
    <feature type="repeat" description="RCC1" evidence="17">
        <location>
            <begin position="370"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="17">
        <location>
            <begin position="469"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="543" mass="57733" checksum="93C7CEBF0C0528AA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAE7</accession>
    <name>A0A670JAE7_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Craniata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="RT_nLTR_like"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
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    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
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    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="555"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1010" mass="116699" checksum="F3D89E06A043833F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBJ7</accession>
    <name>A0A670JBJ7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxylysine kinase</fullName>
            <ecNumber evidence="8">2.7.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HYKK</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19049"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57882"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58357"/>
            <dbReference type="EC" id="2.7.1.81"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.81" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028600452.1">
        <property type="nucleotide sequence ID" value="XM_028744619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JBJ7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023181.1">
        <property type="protein sequence ID" value="ENSPMRP00000021838.1"/>
        <property type="gene ID" value="ENSPMRG00000014179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604490"/>
    <dbReference type="KEGG" id="pmua:114604490"/>
    <dbReference type="CTD" id="123688"/>
    <dbReference type="GeneTree" id="ENSGT00390000011314"/>
    <dbReference type="OrthoDB" id="9973935at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047992">
        <property type="term" value="F:hydroxylysine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000007">
        <property type="entry name" value="hydroxylysine kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050249">
        <property type="entry name" value="Pseudomonas-type_ThrB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064:SF1">
        <property type="entry name" value="HYDROXYLYSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="10">
        <location>
            <begin position="144"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="397" mass="44510" checksum="2BA4C62397856EE1" modified="2020-06-17" version="1">MVLLSLSEWADTEMNEGGEGEAACLQPIRSFLLSFPRQLKNRALHLVLREAQEGAPGRALPQERNLGPFRSRSSPFKAGRAFPGRSSSASCWAWPACAPRSKTSVRDTFSQLAAQRAAHLLKQEAGKKESIPGCPDTGSAKRAYIVRLLSYLPGKTVATIHMSPPLLYELGRMAARMDKTLTEKFQHPLARSLHRGGFIWNLANVPLLEQYIHALGRSEYLDAVKWAIDQFRRKIVPNLHSFRPCIIHGDLNDHNILVDTDFTSPKRSQYRVSGILDFSDMNYGCYVFEVAILIMYMMIESKDPLSVGGHVLAGYESIVPLTEEERDALFLLVSGRFAQSLVMAAYTTLLQPENEEYLMTTSKTGWKHLLLLFEMGQKAVEMIWFNTAEAYAKKGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBX1</accession>
    <name>A0A670JBX1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670JBX1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023121.1">
        <property type="protein sequence ID" value="ENSPMRP00000021786.1"/>
        <property type="gene ID" value="ENSPMRG00000014147.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="510" mass="58381" checksum="A01CB7641F00C38A" modified="2020-06-17" version="1">MLKILQGRLKQYVDRELTEVQAGFRRGRGTRDQIANMRWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTTDWFKIGKGVRQGCILSPCLFNLYAEFIMQKAGLDESQAGIKIAGRNINNLRYADDTTLMAESEEELKNLLMRVKEESAKYGLKLNIKKTKIMATGPITSWQIEGEEMEAVRDFTLLGSMIIADGDSSHEIKRHLLLGRKATTNLDSILKSRDITLPTKVRIVKAMVFPVVMYGSESWTIKKADCRRIDAFELWCWKRLLRIPWTARRSNVPILKEISPECSLEGQILKLRLQYFGHLMRRKGSLEKTLMLGKMEGTRRRGRQRTRWLDSVLGATSMSLTKLREAVEDRRAWRALVHGVTKSRTRLNDNNNNNNNNNKRSTWPLFHLRTCVRTSKAPGVRRGGGGKALCRRVPLFLRFPPSALTAAGWAFTSPRVLQLPACNCVATAQLLALLREGERRSRDPGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFI0</accession>
    <name>A0A670JFI0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HERPUD2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Could be involved in the unfolded protein response (UPR) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028606093.1">
        <property type="nucleotide sequence ID" value="XM_028750260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JFI0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024809.1">
        <property type="protein sequence ID" value="ENSPMRP00000023368.1"/>
        <property type="gene ID" value="ENSPMRG00000015168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607247"/>
    <dbReference type="KEGG" id="pmua:114607247"/>
    <dbReference type="CTD" id="64224"/>
    <dbReference type="GeneTree" id="ENSGT00390000017671"/>
    <dbReference type="OMA" id="YMQLMAA"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17119">
        <property type="entry name" value="Ubl_HERP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000046">
        <property type="entry name" value="Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF5">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="401" mass="44551" checksum="69B1A5A46C196D88" modified="2020-06-17" version="1">METPAAGPPPVTLIIKAPNQKYTDQTIRCFLDWTVGRLKGHLSKVYPSKPSTKDQRLVYSGRLLPDHLQLKDILRKQDEYHMVHLVCSSRTPPNSPKPDTLRENNGSSAPSNNSSSEHSGSTTPSPSQESSHTAGSDGVRHRNLAQSNPVQSHPFPYIMQGNVGNQFPGQGVPAAFPVYPAFSPLQMIWWQQMYARQYYMQYQAAVSAQATPSTESDSPPVPQPPNSERAPANEPPAAPNVAPQENRPVNQNVQMNAQGGPVMNEEDFNRDWLDWMYTFSRAAILLSIVYFYSSFSRFVMVMGAMLLVYLHQAGWFPFRQEGLQQPPGNNEDLNHDGQNVNNAGLEEMEHLMDDGMDEDSGEDVVDVNAEHPHPGFMASAWSFITTFFTSLIPEGPPQVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JGQ4</accession>
    <name>A0A670JGQ4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="5 15">3.6.1.59</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'-&gt;5' exosome-mediated mRNA decay pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="5 15"/>
    <dbReference type="AlphaFoldDB" id="A0A670JGQ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023646.1">
        <property type="protein sequence ID" value="ENSPMRP00000022262.1"/>
        <property type="gene ID" value="ENSPMRG00000014476.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003924"/>
    <dbReference type="OMA" id="RAYFHYQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.40:FF:000001">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000006">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR028973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="308" mass="35062" checksum="4A33DAFED58F97E0" modified="2020-06-17" version="1">MLSPGVPQIGAKRKREAKDGENGDAESQGEGPGAGTFPLAEISVRKVLRESARDKTIFLHGQVNSASGDGTDAVVILEKTPFQEENIAELLKKHTKLQLQMSNDIYSTYHLYLPPELNEIKTTVVYPATEKHLQKYLRQELFSIQWVYNILEKKAEADRIIYENPDPAHGFVLIPDFKWNQKQVDHLYLIATCHCRGIKSLRDLTAEHLPLLRNISREGKEAIVKRFGIGGAQLRVYLHYQPSYYHLHVHFTALGYDTPGCTVERAHLLSDVIDHLERDSQYYQKCTLTFALRAVEPLLKKFQEAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JH06</accession>
    <name>A0A670JH06_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JH06"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025390.1">
        <property type="protein sequence ID" value="ENSPMRP00000023928.1"/>
        <property type="gene ID" value="ENSPMRG00000015484.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183173"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="2">
        <location>
            <begin position="87"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="347" mass="38670" checksum="ABF293CA0922841F" modified="2020-06-17" version="1">MLRKLKSRHQVKPFWPQRCWKTQWLQVSLPRGPVTLRPLLNCRGLGQRGEGNWCLPGGVLALRPREAGLLGAGTAPDPGADAPAPGKYPVALPEKFDGTLASFPMFFAQAKLYIQGRARNFPDDRTKVHFLISLLKDQAAKWALPLLRQDSPLLTDYVGFCNHLETVFGNPLKESQANRAIRQLRQDKSTAAAYATEFRLLAQDLSWNDSALRDQYLEGLSDEILDQLAMMDRPTTLDALIQRSLQIDDRLEDRRQARDHQHSRLLAPVLPSRSTPTAELPVEPTQLGAARPRLSPSEKTRRPKARRKETEGSGGSASEESRKEETQGAEGPREEQSGGKGGVRLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHP1</accession>
    <name>A0A670JHP1_PODMU</name>
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        <recommendedName>
            <fullName evidence="14">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114582000</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028558580.1">
        <property type="nucleotide sequence ID" value="XM_028702747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JHP1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024942.1">
        <property type="protein sequence ID" value="ENSPMRP00000023500.1"/>
        <property type="gene ID" value="ENSPMRG00000015237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582000"/>
    <dbReference type="KEGG" id="pmua:114582000"/>
    <dbReference type="GeneTree" id="ENSGT00940000157947"/>
    <dbReference type="OMA" id="DSEECYM"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008206">
        <property type="term" value="P:bile acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000005">
        <property type="entry name" value="Solute carrier family 27 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006134">
        <property type="entry name" value="PRK08279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF4">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="18">
        <location>
            <begin position="61"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="19">
        <location>
            <begin position="496"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="620" mass="69583" checksum="6ED42D2947D8DF19" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJC2</accession>
    <name>A0A670JJC2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase C-binding protein NELL2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NEL-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NELL2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="87"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="343" mass="39206" checksum="FB7B8A73831D6D64" modified="2020-06-17" version="1">MWKDTEYFKNKGELHRCAVFCLLQIAPSVAGPKYQLLACTTLRLAHIQDAFRTHDLAVTGNEESSFWLPLYGSVCCRLAAQPNSMLHQVMCGFLKVQGEQQGWLRLFCLLRGSNLLCYRHPKDVETQEEAAFTIAINKETRIRATEKDPKNQLHTMSVTNRYGGEEVTHTLLAESRSETQRWMETFWQHFYDMSQWKHCCDELMKVEVPSPRRPMALLQKQGSLYHEMAIEPADDIEAVTEILQELIRIGSFVQAPPPQLHHPQRWPQRSPPRLPCPPTAPRFSNAPPEFQGYVPIQEGRGGACCQVGRRDPPHLWGGGQPCLFLEYALKNVSIYPSIYLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJV5</accession>
    <name>A0A670JJV5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JJV5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025261.1">
        <property type="protein sequence ID" value="ENSPMRP00000023804.1"/>
        <property type="gene ID" value="ENSPMRG00000015414.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000025271.1">
        <property type="protein sequence ID" value="ENSPMRP00000023814.1"/>
        <property type="gene ID" value="ENSPMRG00000015421.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010734"/>
    <dbReference type="OMA" id="SNLMMDV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="131" mass="14286" checksum="A47F740F43FD8FC7" modified="2020-06-17" version="1">SSITKALGDGGKMNSRAFGSQLKDCIPVSDFSAAGAFESCDVINRGFTNVKSKLFPVHPLDTPDNFVVLQMEFQAVKLLQHFPFLPSSNLSLDIWKGNCDCIGFEDILNDPAQSEGMGDPHLLVEHKLGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JL64</accession>
    <name>A0A670JL64_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sorting nexin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SNX13</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JL64"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025727.1">
        <property type="protein sequence ID" value="ENSPMRP00000024259.1"/>
        <property type="gene ID" value="ENSPMRG00000015679.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182856"/>
    <dbReference type="OMA" id="CETINNT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06873">
        <property type="entry name" value="PX_SNX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08719">
        <property type="entry name" value="RGS_SNX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000014">
        <property type="entry name" value="Sorting nexin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000007">
        <property type="entry name" value="sorting nexin-13 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037437">
        <property type="entry name" value="SNX13_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037896">
        <property type="entry name" value="SNX13_RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="14">
        <location>
            <begin position="97"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="12">
        <location>
            <begin position="373"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="559"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="969" mass="112521" checksum="15029A7DF75C56A2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JL74</accession>
    <name>A0A670JL74_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">SCAP</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SCAP family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPMRP00000024269.1"/>
        <property type="gene ID" value="ENSPMRG00000015376.1"/>
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        <property type="component" value="Chromosome 12"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045542">
        <property type="term" value="P:positive regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042304">
        <property type="term" value="P:regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000391">
        <property type="entry name" value="sterol regulatory element-binding protein cleavage-activating protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057042">
        <property type="entry name" value="Beta-prop_SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057041">
        <property type="entry name" value="SCAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24017">
        <property type="entry name" value="Beta-prop_SCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24006">
        <property type="entry name" value="SCAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 21" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="24">
        <location>
            <begin position="284"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="1131"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="592"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="851"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1295" mass="142883" checksum="D71609249953586C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLP5</accession>
    <name>A0A670JLP5_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
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        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
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        <property type="component" value="Chromosome 9"/>
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    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exo_endo_phos_2"/>
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    </dbReference>
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        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="401"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="786"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="817" mass="94380" checksum="3159369E07F5D82D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JMZ1</accession>
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        <recommendedName>
            <fullName evidence="10">Polycomb protein SCMH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sex comb on midleg homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SCMH1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598594.1">
        <property type="nucleotide sequence ID" value="XM_028742761.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028598595.1">
        <property type="nucleotide sequence ID" value="XM_028742762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JMZ1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025825.1">
        <property type="protein sequence ID" value="ENSPMRP00000024347.1"/>
        <property type="gene ID" value="ENSPMRG00000015730.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603608"/>
    <dbReference type="KEGG" id="pmua:114603608"/>
    <dbReference type="CTD" id="22955"/>
    <dbReference type="GeneTree" id="ENSGT00940000157999"/>
    <dbReference type="OMA" id="NKEFCSM"/>
    <dbReference type="OrthoDB" id="5912862at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010369">
        <property type="term" value="C:chromocenter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20105">
        <property type="entry name" value="MBT_SCMH1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20108">
        <property type="entry name" value="MBT_SCMH1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09578">
        <property type="entry name" value="SAM_Scm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000018">
        <property type="entry name" value="Polycomb protein scmh1 isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.190:FF:000001">
        <property type="entry name" value="Polycomb protein scmh1 isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000016">
        <property type="entry name" value="polycomb protein SCMH1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.190">
        <property type="entry name" value="SLED domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047279">
        <property type="entry name" value="MBT_SCMH1_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047280">
        <property type="entry name" value="MBT_SCMH1_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047531">
        <property type="entry name" value="SAM_Scm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033763">
        <property type="entry name" value="SCML2_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021987">
        <property type="entry name" value="SLED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038348">
        <property type="entry name" value="SLED_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF68">
        <property type="entry name" value="POLYCOMB PROTEIN SCMH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17208">
        <property type="entry name" value="RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12140">
        <property type="entry name" value="SLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="MBT" evidence="12">
        <location>
            <begin position="34"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="12">
        <location>
            <begin position="140"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="626"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="245"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="693" mass="77137" checksum="E95B9705CFDF0841" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNL1</accession>
    <name>A0A670JNL1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 46 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SLC46A2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. SLC46A family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPMRP00000026001.1"/>
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        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140360">
        <property type="term" value="F:cyclic-GMP-AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140361">
        <property type="term" value="P:cyclic-GMP-AMP transmembrane import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:mitochondrial outer membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005757">
        <property type="term" value="C:mitochondrial permeability transition pore complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051434">
        <property type="term" value="F:BH3 domain binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1990117">
        <property type="term" value="P:B cell receptor apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010248">
        <property type="term" value="P:establishment or maintenance of transmembrane electrochemical gradient"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097194">
        <property type="term" value="P:execution phase of apoptosis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial fragmentation involved in apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial fusion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of mitochondrial membrane potential"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of apoptotic DNA fragmentation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001244">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0031334">
        <property type="term" value="P:positive regulation of protein-containing complex assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of release of cytochrome c from mitochondria"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:release of cytochrome c from mitochondria"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:release of matrix enzymes from mitochondria"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to toxic substance"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:supramolecular fiber organization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.437.10:FF:000004">
        <property type="entry name" value="apoptosis regulator BAX isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
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    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
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    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
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    <dbReference type="InterPro" id="IPR020726">
        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF42">
        <property type="entry name" value="APOPTOSIS REGULATOR BAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="18">
        <location>
            <begin position="64"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="192" mass="21593" checksum="CBB9203716061B4D" modified="2020-06-17" version="1">MLLSLPGSRSDQILQTGTVLLKGFIRDRVQCCGDSGRIDATMAELGVSESEACDPKTKQLSDCLRRIGDELDGNMELQRMIEQVQMYPPKEVFFRVAAEMFSDGTFNWGRVVALFYFACKLVLKAICTKLPELIRTIISWTMEYIQNHVLSWIQAQGGWEGLLSYFGTPTWQTIAVFAAGVLTASLTFWKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRZ0</accession>
    <name>A0A670JRZ0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CD37 molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CD37</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JRZ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029481.1">
        <property type="protein sequence ID" value="ENSPMRP00000027793.1"/>
        <property type="gene ID" value="ENSPMRG00000017941.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161485"/>
    <dbReference type="OMA" id="WLTENIY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03160">
        <property type="entry name" value="CD37_CD82_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF263">
        <property type="entry name" value="LEUKOCYTE ANTIGEN CD37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="395" mass="43038" checksum="D8390FA09FD76F77" modified="2020-06-17" version="1">MSRKGCIAVTKYFLFLFNFLFFLLGGLLFSFGLWLLFDRDSFAAVLGSAYYALKIWSYIFCGVGILTMWMGFLGCLGSLKEIKCMLGCYFAFLLLLFLAQIIIGILVYSQSKTLNTKVGDYVTEIIEHYGTYNPSTDEEESWDYVQMELQCCGWILSNDWMENSIIKNSSYHLYPCSCSGNVSQPDQPGNGTTAAPTTRPKIAGFCNSYGQPWSVYEMGCMDGVQTWLTNNIVTIVGISLGIALMEVRGLGELLQVGVAAVLRSCARSRTAGIANSSGGCGGAPPLPWPPGSWVAAAYQEGEGKAATRRLARCKRTAATSLLLVCLHLPSAALPLSCPVNSSDSTAGRSGERCHAAMPPTTYLLDLPPGKLLELFIFHLPHLAIRGAHFPEKQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JS80</accession>
    <name>A0A670JS80_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RAB7A interacting MON1-CCZ1 complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RIMOC1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            <authorList>
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        </citation>
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            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
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    <sequence length="375" mass="42321" checksum="FA41E8DB875A75DB" modified="2020-06-17" version="1">MAGDVRVPKPGSGLSGFKTQESREVAPLYTFPISRGYKASAARSSHPLCWSISRDEEKKERGVVCVAAASLDLGSELCAFQMAGAGFAAELRLRLAALKGRLQRSSQSEEASEDPFLMQASATLENLTDLCNQPGENGTLSKLLQLYTQAVLDITYFEENQLVDEDFPEESSLQKVEELINTLSEPEILINESGTSQEPLAVLGVELLECLYWRRGALLYMFCHTVKGRKERLMNKTDLFKKFLNEGIQYLVKMLEFRCSDHPIEDFVFQDTDTARLIHEGIFSDTHLLAMMYCGEMCYWGLKYCREVKERSRSVEAGSSREQPGSSQSEVLDHRETGEKVLLKYITVCEGPLRLHDWDTKNAKLILDYFKQFSA</sequence>
</entry>
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    <accession>A0A670JUF3</accession>
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            <fullName evidence="4">ZW10 interacting kinetochore protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Laterata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="entry name" value="ZW10 INTERACTOR"/>
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        <location>
            <begin position="144"/>
            <end position="270"/>
        </location>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="469" mass="53411" checksum="57368CCCBE4D8738" modified="2020-06-17" version="1">MLPRKEEGQRGICTSIICDNWTLQRTIFAGSFLKRDLISDLGEGGDEKGKNGLTMRYDITGMRSNDSLICWRSGIIPLLARVKDALAFESQAQYGVEADLPPQVLAEHAVSTRHAHKFMLMQLQVLKFCLDFLDSGLCVENASKSSVRQEVAEAKQEWKKLKAEYQQQVESIQKDVPQLLLKLEQAWNRAQLLEEALQRYQDKKLEMEEKARSAQKRQQKEQDALYEQQRRLEERMAELQGSLQAQREELQQLRRELEEEERQACAWQEEVQRISDFRSLLETLQGVRLLSESKSDLEFELISPAQPGAATPHALKLRLHWRDDGSVMLQSDSPFFPPSLVLPEGTCGNIRAIVLELQNSYFQQAQLLAEIELLHSCPLRRDLRCGTGWNISVPWTSTLLSLPERLLLPLPVQGEERFGTRTSLRSCSPCLYPGEGEETLPGTAAFSFLVLAHFSSFPLNPWSLLMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JV26</accession>
    <name>A0A670JV26_PODMU</name>
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        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">VPS45</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JV26"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029441.1">
        <property type="protein sequence ID" value="ENSPMRP00000027755.1"/>
        <property type="gene ID" value="ENSPMRG00000017865.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
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    </dbReference>
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        <property type="entry name" value="vacuolar protein sorting-associated protein 45 isoform X1"/>
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        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
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        <property type="entry name" value="Sec-1-like_dom1"/>
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    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
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        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="650" mass="73713" checksum="F91A178E562D5B44" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JV32</accession>
    <name>A0A670JV32_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Complexin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CPLX3</name>
    </gene>
    <organism evidence="8 9">
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        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complexin/synaphin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028744975.1"/>
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    <dbReference type="Ensembl" id="ENSPMRT00000030033.1">
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        <property type="gene ID" value="ENSPMRG00000018268.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114604643"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:SNARE complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:syntaxin binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of synaptic vesicle fusion to presynaptic active zone membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Complexin_NTD_CPLX_III_IV"/>
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    </dbReference>
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        <property type="entry name" value="Single Helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="157" mass="17656" checksum="7F15A390395D3397" modified="2020-06-17" version="1">MAFMVKSMVGGQLKNLTGGLGGEEKGEGEKSPAEAQGMTKEEYEEYQKQLVEEKMERDAQFAQRKAERATLRTHFRDKYRLPKNETDDNQIQLVGGDVELPKELAKMIEQDNEEEEEKDSVIGQLTSIQNLDLDSLKGKAQATLDDLKQSAEKCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JWX6"/>
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        <property type="gene ID" value="ENSPMRG00000018728.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154179"/>
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    <dbReference type="Proteomes" id="UP000472272">
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="13851" checksum="999DD0E11CE058CF" modified="2020-06-17" version="1">CCWTPALLSPSQHGGLAQFVLTQPLLLSASPGETINISCTRSSGNIASYAVSWYQQKPGRQVPRLILYQTSTRPSGIPARFSGSKSGNTMSLTITGAQAEDEATYYCCVLHPGVSCTAGHSDGEVRQKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JX41</accession>
    <name>A0A670JX41_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CTDSP1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A670JX41"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031667.1">
        <property type="protein sequence ID" value="ENSPMRP00000029858.1"/>
        <property type="gene ID" value="ENSPMRG00000019308.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240451"/>
    <dbReference type="OMA" id="MDLIPFF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050768">
        <property type="term" value="P:negative regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000013">
        <property type="entry name" value="Carboxy-terminal domain RNA polymerase II polypeptide A small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040078">
        <property type="entry name" value="RNA_Pol_CTD_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01124">
        <property type="entry name" value="C0.1:_RNA_Pol_CTD_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="263" mass="29544" checksum="3D9C2B264B60E3B2" modified="2020-06-17" version="1">MTALPSYLYLSLSPPPSSPSPPSHAGAQNPSPSKKPRNRSIFQSLFCCLCHDNSEPIPVNNNAPLLVEENGSVPKATVKYLLPETKPQDSSKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVMHQVYVLKRPHVDEFLRRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLTRIIIVDNSPASYVFHPDNAVPVASWFDNMADTELLDLLPFFERLSKVDDVYTVLKQHRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYG9</accession>
    <name>A0A670JYG9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myogenic factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MYF6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028603154.1">
        <property type="nucleotide sequence ID" value="XM_028747321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JYG9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031398.1">
        <property type="protein sequence ID" value="ENSPMRP00000029606.1"/>
        <property type="gene ID" value="ENSPMRG00000019140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605760"/>
    <dbReference type="KEGG" id="pmua:114605760"/>
    <dbReference type="CTD" id="4618"/>
    <dbReference type="GeneTree" id="ENSGT00950000182959"/>
    <dbReference type="OMA" id="CPSEWGN"/>
    <dbReference type="OrthoDB" id="10049614at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060415">
        <property type="term" value="P:muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048743">
        <property type="term" value="P:positive regulation of skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18934">
        <property type="entry name" value="bHLH_TS_MRF4_Myf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000005">
        <property type="entry name" value="Myogenic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002546">
        <property type="entry name" value="MyoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039704">
        <property type="entry name" value="Myogenic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534">
        <property type="entry name" value="MYOGENIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534:SF4">
        <property type="entry name" value="MYOGENIC FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01586">
        <property type="entry name" value="Basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00520">
        <property type="entry name" value="BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="268" mass="28514" checksum="47CB40DD3F975A34" modified="2020-06-17" version="1">MMMDLFEPGSYFFYLDAGDHGGLQALDMADEGSPLYPGSEGPLSPSSCPDQLAPEAGGGGGGDSSSGSSSIGADEEQHVLAPPGLQAPHCPGQCLMWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAISYIERLQDLLHRLDQQDKSHQQLLLPANGGAVGDAFAGSAKQGHVPPPDFLSPCSADWPSGSEHSRALPIGAKEGNPLGDSSASSSLRCLSSIVDSISSEDRRVPSGEEVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZA2</accession>
    <name>A0A670JZA2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Retinoblastoma-like protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">130 kDa retinoblastoma-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Retinoblastoma-related protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">pRb2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RBL2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the retinoblastoma protein (RB) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028596009.1">
        <property type="nucleotide sequence ID" value="XM_028740176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JZA2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030975.1">
        <property type="protein sequence ID" value="ENSPMRP00000029205.1"/>
        <property type="gene ID" value="ENSPMRG00000018868.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602222"/>
    <dbReference type="KEGG" id="pmua:114602222"/>
    <dbReference type="CTD" id="5934"/>
    <dbReference type="GeneTree" id="ENSGT00950000183202"/>
    <dbReference type="OMA" id="VYCQSTQ"/>
    <dbReference type="OrthoDB" id="844594at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Carretero M.A."/>
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        <location>
            <begin position="136"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
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        <location>
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            <end position="44"/>
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        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="349" mass="35287" checksum="AD4862665808428C" modified="2020-06-17" version="1">MLLYSLRSGTATSAAGEDPAAQRDPPCKLTSMDSDASLVSSRPSSPEPDELFVSSRSKSGGGGGFSAGGAVSSSTPSDSPAELSAELRSAMSAAGVVMVDKLAFKSPSSSSSSSSSSSSSASKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLLSEIYGGHHAAGFHPAAAAAAAAAACPGGMVGHSAPLPGHPASHAVHHPILPPAAVSSASLPGSAGLSAVSSIRPSHGLLKSPSSAAAAAAAAAAAAAAAAASGPLGSSFQHWGGMPCPCSMCQVPAPSHHHVSSMNTASLPRLTSDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K242</accession>
    <name>A0A670K242_PODMU</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PABPN1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="ENSPMRG00000020477.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154606"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="polyadenylate-binding protein 2"/>
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    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="196"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
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        <location>
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            <end position="173"/>
        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="353" mass="36771" checksum="9709D78802C24010" modified="2020-06-17" version="1">MASVRGPSSVGGGRGAAAALGGEGEPGGGLVGGPPSSQYGNGLGGSGPGGEQGGGLRELEEEEEEGLLLEAATGGGAAGGGGIRGSGPRGALSSSSSSSHAPSRAGQAGVGGPHHHPHSEELEEEAGLGESDPGDSAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSLEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKYTGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRTRYRGRGSGYSSSRARFYSGFSSRPPRGRAYRSGTTVVAGWGRRFYAPALQGFPWGGGWSRGDLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4S4</accession>
    <name>A0A670K4S4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ETS transcription factor ERG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ERG</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETS family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028727175.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583009.1">
        <property type="nucleotide sequence ID" value="XM_028727176.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583010.1">
        <property type="nucleotide sequence ID" value="XM_028727177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K4S4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034492.1">
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        <property type="gene ID" value="ENSPMRG00000021074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596089"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08540">
        <property type="entry name" value="SAM_PNT-ERG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000010">
        <property type="entry name" value="Fli-1 proto-oncogene, ETS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000039">
        <property type="entry name" value="Friend leukemia integration 1 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF216">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ERG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
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    <sequence length="801" mass="84978" checksum="68B7D2142C080976" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K639</accession>
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        <submittedName>
            <fullName evidence="8">SLAM family member 7-like</fullName>
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        <name evidence="8" type="primary">LOC114586738</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
    <sequence length="303" mass="34480" checksum="C265833EA141D620" modified="2020-06-17" version="1">MMVEVASRSLLVILLFAPWICTSFGSLSHGMENPIYQVKGILGESVLFAVNVSSSVTVEKMEWDFYPQSGGLGFWLGEFSHGKLEHPSPTDRFRQRLDMVDEMTLRIKDLELDDGGIYNARIWFTKAQFQEQSFSLMVYEPVPELQILLRDVSNSSGICDVTLQCQVSGKGEFDISWKRGEPLRDLGDGLVGYQISDNGTSLHLLWWPNASDSTFTCLVRNPIGEKDVSFNLLSICQTDDEGSQQRLWWMICLPISFILTLACSVIIWKRKYIFKKRDCLHNSREPALSCITTDNEERPQSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8X5</accession>
    <name>A0A670K8X5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K8X5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033977.1">
        <property type="protein sequence ID" value="ENSPMRP00000032039.1"/>
        <property type="gene ID" value="ENSPMRG00000020755.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182788"/>
    <dbReference type="OMA" id="CFECAED"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000024">
        <property type="entry name" value="Vomeronasal 2, receptor 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="498"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="763" mass="85938" checksum="11E9994B2AA72011" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9P4</accession>
    <name>A0A670K9P4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MHC class II family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K9P4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033437.1">
        <property type="protein sequence ID" value="ENSPMRP00000031522.1"/>
        <property type="gene ID" value="ENSPMRG00000020392.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161847"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002504">
        <property type="term" value="P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05767">
        <property type="entry name" value="IgC1_MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001003">
        <property type="entry name" value="MHC_II_a_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF86">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00993">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00920">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0491">MHC II</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025366154" description="Ig-like domain-containing protein" evidence="13">
        <location>
            <begin position="34"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="115"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="256" mass="28426" checksum="A04B80DECBC714E4" modified="2020-06-17" version="1">MEPRGGRGGGGGGRALCCLWATLLLAPPRGAGALKGRGAQEGGGDAWGGFLLEFDNEEILHVDWEKKQNVWRLPDFQRFTSFEVQGALANIAVMKNNMEVLMKRSNRTRALNVAPSATVYPENAVELGDPNVLICFVDRFSPPVLNVTWLKNNEVVSEGVEETDFYPSVDNTFRKFSYLPFVPEQGDIYVCQVEHWGIPEGKMEKIWGKHRAPSPIPETMENVLCALGLAFGMLGIIAGTILFFKAMRMNDRRGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KC37</accession>
    <name>A0A670KC37_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratin, type II cytoskeletal 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114593000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028577295.1">
        <property type="nucleotide sequence ID" value="XM_028721462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KC37"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037152.1">
        <property type="protein sequence ID" value="ENSPMRP00000035038.1"/>
        <property type="gene ID" value="ENSPMRG00000022675.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593000"/>
    <dbReference type="KEGG" id="pmua:114593000"/>
    <dbReference type="GeneTree" id="ENSGT00940000155862"/>
    <dbReference type="OMA" id="RWVHDAM"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF69">
        <property type="entry name" value="IF ROD DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="178"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="182"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="389"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="611" mass="63694" checksum="18E376529AF8EE94" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KC87</accession>
    <name>A0A670KC87_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KC87"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036533.1">
        <property type="protein sequence ID" value="ENSPMRP00000034436.1"/>
        <property type="gene ID" value="ENSPMRG00000022318.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003095">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000806">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000238">
        <property type="entry name" value="Zinc finger protein 485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="609" mass="68912" checksum="7787467925467E35" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KD01</accession>
    <name>A0A670KD01_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">T-box transcription factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TBX5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028565556.1">
        <property type="nucleotide sequence ID" value="XM_028709723.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565557.1">
        <property type="nucleotide sequence ID" value="XM_028709724.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565558.1">
        <property type="nucleotide sequence ID" value="XM_028709725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KD01"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036828.1">
        <property type="protein sequence ID" value="ENSPMRP00000034721.1"/>
        <property type="gene ID" value="ENSPMRG00000022493.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586365"/>
    <dbReference type="KEGG" id="pmua:114586365"/>
    <dbReference type="CTD" id="6910"/>
    <dbReference type="GeneTree" id="ENSGT00940000156506"/>
    <dbReference type="OMA" id="CMYASSV"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003218">
        <property type="term" value="P:cardiac left ventricle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060044">
        <property type="term" value="P:negative regulation of cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060039">
        <property type="term" value="P:pericardium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051891">
        <property type="term" value="P:positive regulation of cardioblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20189">
        <property type="entry name" value="T-box_TBX4_5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000005">
        <property type="entry name" value="T-box transcription factor TBX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF28">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="10">
        <location>
            <begin position="58"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="522" mass="58205" checksum="68E07F58BB4FCB74" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDP9</accession>
    <name>A0A670KDP9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670KDP9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036604.1">
        <property type="protein sequence ID" value="ENSPMRP00000034505.1"/>
        <property type="gene ID" value="ENSPMRG00000022394.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="CVKHSKL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="372" mass="43019" checksum="478F4F48D2B0C3D6" modified="2020-06-17" version="1">MEKAREFQKDIYFCFIDYAKAFDCVKHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTTDWFKIGKGVRQGCILSPCLFNLYAEFIMRKAGLDESQTGIKIAGRNINNLRYADDTTLMAESEEELKNLLMRVKEESAKYGLKLNIKKTKIMATGPISSWQIEGEEMEAVRDFTFLGSMITADGDSSHDIKRRLLLGRKAMANLDSLLKSRDITLPTKVRIVKAMVFPVVMYGSESWTIKKADRRRIDAFELWCWRRLLRVPWTARRSNHSILKEISPECSLEGQIVKLRLQNFGHLMRREDSLEKTLMLGKIEGTRRRGRQRTRWLDGVLEATNMSLTKLREAVEDRSAWRALVHGVTKSWTRLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KE22</accession>
    <name>A0A670KE22_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Barrier-to-autointegration factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Barrier-to-autointegration factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Barrier-to-autointegration factor-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homodimer. Heterodimerizes with BANF2. Interacts with ANKLE2/LEM4, leading to decreased phosphorylation by VRK1 and promoting dephosphorylation by protein phosphatase 2A (PP2A). Binds non-specifically to double-stranded DNA, and is found as a hexamer or dodecamer upon DNA binding. Binds to LEM domain-containing nuclear proteins such as LEMD3/MAN1, TMPO/LAP2 and EMD (emerin). Interacts with ANKLE1 (via LEM domain); the interaction may favor BANF1 dimerization. Interacts with CRX and LMNA (lamin-A). Binds linker histone H1.1 and core histones H3. Interacts with LEMD2 (via LEM domain). Interacts with PARP1; interaction takes place in response to oxidative DNA damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the BAF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KE22"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036733.1">
        <property type="protein sequence ID" value="ENSPMRP00000034630.1"/>
        <property type="gene ID" value="ENSPMRG00000022452.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018613"/>
    <dbReference type="OMA" id="KHRDFMA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.40:FF:000002">
        <property type="entry name" value="Barrier to autointegration factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF7">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="86" mass="9632" checksum="9F1E3DD088A665F6" modified="2020-06-17" version="1">MTTSQKHQDFVAEPIGDKSLGTLVGIGDVLGRKLEDKGFDKAYVVLGQFLVLKDLFREWLKDTCGANAKQSRDCYGCLKEWCDAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEX9</accession>
    <name>A0A670KEX9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Exonuclease V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">EXO5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KEX9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037571.1">
        <property type="protein sequence ID" value="ENSPMRP00000035441.1"/>
        <property type="gene ID" value="ENSPMRG00000022921.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015205"/>
    <dbReference type="OMA" id="CPDKPLG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000004">
        <property type="entry name" value="Probable exonuclease V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00070137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="361" mass="40766" checksum="DC5C2164958299FE" modified="2020-06-17" version="1">MVVRVLDQDLARPGFKSSLSHKAHGVTLGQSLYLSQTLTHWPSCSLGPPTEPEGGDVAKGNVLETAKRKRSHVPLEIFHLRYLSVTDISAQVWCEQQMVYRRERPDLTTPENIVLLNTGKSIHLARELEDHDLVTVSTTSREDSWAIKVLNLLGMLLVLQEGHRVREFPVFGVLEDIFVVGVIDQLGYTPKGELELNELKTQNNASMPSAAQKKRDRFQVFLYKYLFDAMVQGCLAPEQPLGPHVQDQARKSGFTVSHFRDLLELLSLNLTHCEIPAIDRLQIEYIHQDSGTALGTEVVAYDQDEVGAAVRYFLAYWKGQRDSRGVDVEDAWKCRYCAYAGICEWRMGKAGSPAERWKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KHA3</accession>
    <name>A0A670KHA3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiosis-specific nuclear structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MNS1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KHA3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038543.1">
        <property type="protein sequence ID" value="ENSPMRP00000036376.1"/>
        <property type="gene ID" value="ENSPMRG00000023479.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111210"/>
    <dbReference type="OMA" id="QIRNQMV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160111">
        <property type="term" value="C:axonemal A tubule inner sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070986">
        <property type="term" value="P:left/right axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026504">
        <property type="entry name" value="MNS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265:SF0">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="15">
        <location>
            <begin position="117"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="62"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="249"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="489" mass="60177" checksum="E4A26BD4ECAF790C" modified="2020-06-17" version="1">MARQRGGRAPLTAAQQLDKKQHEAYFQEMRELEHMKKVQRVHQLEVMWEAEDRVEEKRLARLLREEEHERRMEEAIQRAEENKRLKEMELQQEEKLAAELARLNHEKLKDEKMRQQIRETSIELRELELKLKSAYMNKARAAQIAEKEAIKYEKMKDDAEICKAMKEAQEKAEEEERTAEAKRNQEKLLYQQELERQLEDRERQRQAAYEEFLREKLLIDEIVRKIYDEDERAKQGRLEKMRATQRFIEEFKNDQAMRKKRQREEMEEENRKLKEFANMWQEREDNRMAKIQENEERKQKEQQEREELEQIREELYFEEREEENRKKEMEELEKKLRQRLELRKAYEDQLAMREVMRQAMKEEEEAFRQSMLAKFAEDDRVEQMNAQKRRMKQLEHRREVEKLIEERRKQFIADKERELEEMQLEERRKGIVNDIIEEERQKLLKEHAVKLLGYLPRGVLKDEQDVNMLGEEFRQAYQKRKGDGPAHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJA1</accession>
    <name>A0A670KJA1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KJA1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039346.1">
        <property type="protein sequence ID" value="ENSPMRP00000037161.1"/>
        <property type="gene ID" value="ENSPMRG00000023913.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183173"/>
    <dbReference type="OMA" id="LEGHETC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="371" mass="41316" checksum="4CCB6ED126ED3207" modified="2020-06-17" version="1">MMDRPTTLDALIQRSLQIDDRLEDRRQARDHQHSRLLAPVLPSRSTPTAELPVEPTQLGAARPRLSPSEKTRRREGNLCLYCGGSGHYARSCPKKMPVAGKPPTSVAEGPSNMGSQSMQEGPSPVELRHLMVPVRLYPPGGPWILTHALVDSGATRSYMDAAFAAHHQVPLQNKPEPVQVEAIDGRLLRSGAVTRETQPLVLCLQQHREVRTLDIASMPRFPLVLGMDWLEAHNVQIDWVNRTVHFPDPCPHALSEMLAAAPTEEAVPTLPAVYRDYQDVFKERGADQLPPHQSFDCGIDLQPGAPLPVSRLYSLTEPEREALQDFLRKNLERGFIRPSTSPTAAPVLFVKKKCGELHLCHDYRALNKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HL17</accession>
    <name>A0A670HL17_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">INSC spindle orientation adaptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INSC</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HL17"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000185.1">
        <property type="protein sequence ID" value="ENSPMRP00000000176.1"/>
        <property type="gene ID" value="ENSPMRG00000000119.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009786">
        <property type="term" value="P:regulation of asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21966">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.10">
        <property type="entry name" value="Inscuteable LGN-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045789">
        <property type="entry name" value="Insc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031938">
        <property type="entry name" value="INSC_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038205">
        <property type="entry name" value="INSC_LBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039921">
        <property type="entry name" value="Inscuteable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386">
        <property type="entry name" value="INSCUTEABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386:SF0">
        <property type="entry name" value="PROTEIN INSCUTEABLE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19427">
        <property type="entry name" value="Insc_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16748">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <feature type="domain" description="Protein inscuteable homologue LGN-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="3">
        <location>
            <begin position="73"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="3">
        <location>
            <begin position="543"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="749" mass="82440" checksum="A21FFFB423AD3A52" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HL80</accession>
    <name>A0A670HL80_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670HL80"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000617.1">
        <property type="protein sequence ID" value="ENSPMRP00000000589.1"/>
        <property type="gene ID" value="ENSPMRG00000000448.1"/>
    </dbReference>
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    <dbReference type="OMA" id="CISNEMW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF30">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RVT_1"/>
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    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="233"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="821" mass="93726" checksum="1BD6A1EAF20F3AEA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQ85</accession>
    <name>A0A670HQ85_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sp5 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SP5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQ85"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001966.1">
        <property type="protein sequence ID" value="ENSPMRP00000001848.1"/>
        <property type="gene ID" value="ENSPMRG00000001364.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160673"/>
    <dbReference type="OMA" id="KRFGCAE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060349">
        <property type="term" value="P:bone morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036342">
        <property type="term" value="P:post-anal tail morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000061">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF29">
        <property type="entry name" value="TRANSCRIPTION FACTOR SP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="372" mass="39333" checksum="80F05260628636FC" modified="2020-06-17" version="1">MAAVAVLRNDSLQAFLQDRTPSASPDVAKHSPLALLAATCSRIGQPGASGPPSDFLQVSYEASLGSPSRIFHPWSSDMPAHSPGGLPPPPSLGLTPQPAFGSAHELPLTPPADPSYPYEFSPVKMLPPPPPSMGALSSSCAPPPSAYVPYAAQAALPPAPQLSPAPDDIPWWSIQQAAPGAGGCAHRFAAGNLQRGLVLAPSELAQYQTQLAALLHPKAPLAATARRCRRCRCPNCQAAAAGGGGGGPDGAPSSEPGKKKQHVCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFGCAECGKRFMRSDHLAKHVKTHQNKRLKAAAAPGHGHACATVKREEPRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQS3</accession>
    <name>A0A670HQS3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HQS3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002169.1">
        <property type="protein sequence ID" value="ENSPMRP00000002038.1"/>
        <property type="gene ID" value="ENSPMRG00000001498.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000209945"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF73">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP FC1 ENV POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="289" mass="31958" checksum="5492C9D3A4F7024A" modified="2020-06-17" version="1">MLPANGETYGRALFPAYGAGSNHVDILKLTDILLNFMGRIQCSYLGLILPGVRVTQELPPGKRRNKRAKDLSELSDVAANGETYGRALFPAYGAGSNHVDILKLTDILLNFMEESNAATQSILTELTEVRQNSIQNRLALDYVLASTGGVCALIGTECCTHVTDQTLNITGHLNNIYKLTDKLRDIQHEGLSDTHFWSWLPGSTWIKQLLGNGLLILITVAICIVFFCCMIHCFPMCCQTCGSCLPILHPRSNPIYRPPASEIQSTSIEMGPLHHLRTLDSRYDMSSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HS94</accession>
    <name>A0A670HS94_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox C12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXC12</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028577415.1">
        <property type="nucleotide sequence ID" value="XM_028721582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HS94"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002082.1">
        <property type="protein sequence ID" value="ENSPMRP00000001957.1"/>
        <property type="gene ID" value="ENSPMRG00000001444.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593063"/>
    <dbReference type="KEGG" id="pmua:114593063"/>
    <dbReference type="CTD" id="3228"/>
    <dbReference type="GeneTree" id="ENSGT00940000161307"/>
    <dbReference type="OMA" id="SYYREPC"/>
    <dbReference type="OrthoDB" id="9886711at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46440:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46440">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-D12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="199"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="267" mass="29968" checksum="63B47FD20FE250F6" modified="2020-06-17" version="1">MGEHNLLNPGFVGPLVNIHTGDTFYFPNFRASGGQLPGLPSLSYPRRDNVCSLPWASSEPCNGYPQPYLSSPVSINPSFSRACDLARVEESKCYYREACSENAPLKREERVRDNALMPLESGIPNGMSGSFGKFDYPAPEAVPHDPPSCQSLESDSSSSLLNEGNKGATSEPSTMVSPINQGSNLSAGGAPWYPMHTRSRKKRKPYSKLQLAELEGEFMVNEFITRQRRRELSDRLNLSDQQVKIWFQNRRMKKKRLLLREQALSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HSU0</accession>
    <name>A0A670HSU0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HSU0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003002.1">
        <property type="protein sequence ID" value="ENSPMRP00000002799.1"/>
        <property type="gene ID" value="ENSPMRG00000002020.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234906"/>
    <dbReference type="OMA" id="IRCCFFI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="103" mass="11479" checksum="981FF20C00EDD706" modified="2020-06-17" version="1">MSSILKLTMLVMKLSFRITGLIFFQSFVSSPNRRQMDSKASFTAAGGLPIALTSIRCCFFIELTAIKGMEKRVQHAKTNTEASPISQERKDSDLGENSEEQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HT99</accession>
    <name>A0A670HT99_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Diacylglycerol lipase-alpha</fullName>
            <ecNumber evidence="21">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Neural stem cell-derived dendrite regulator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Sn1-specific diacylglycerol lipase alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">DAGLA</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38511"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38515"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75449"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:38516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = 2-(9Z,12Z-octadecadienoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38523"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75450"/>
            <dbReference type="ChEBI" id="CHEBI:75457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:38524"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38527"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75913"/>
            <dbReference type="ChEBI" id="CHEBI:75914"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38528"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = 2-octadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38519"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75448"/>
            <dbReference type="ChEBI" id="CHEBI:75456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:38520"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:38508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="29">Interacts (via C-terminal) with CAMK2A; leading to the phosphorylation and inhibition of DAGLA enzymatic activity. Interacts (via PPXXF motif) with HOMER1 and HOMER2; this interaction is required for DAGLA membrane localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic density membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="21"/>
    <dbReference type="RefSeq" id="XP_028592811.1">
        <property type="nucleotide sequence ID" value="XM_028736978.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592821.1">
        <property type="nucleotide sequence ID" value="XM_028736988.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592831.1">
        <property type="nucleotide sequence ID" value="XM_028736998.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592839.1">
        <property type="nucleotide sequence ID" value="XM_028737006.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592845.1">
        <property type="nucleotide sequence ID" value="XM_028737012.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592852.1">
        <property type="nucleotide sequence ID" value="XM_028737019.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592860.1">
        <property type="nucleotide sequence ID" value="XM_028737027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HT99"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002618.1">
        <property type="protein sequence ID" value="ENSPMRP00000002460.1"/>
        <property type="gene ID" value="ENSPMRG00000001777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600621"/>
    <dbReference type="KEGG" id="pmua:114600621"/>
    <dbReference type="CTD" id="747"/>
    <dbReference type="GeneTree" id="ENSGT00940000161192"/>
    <dbReference type="OMA" id="YCMVAPE"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032591">
        <property type="term" value="C:dendritic spine membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043196">
        <property type="term" value="C:varicosity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901696">
        <property type="term" value="P:cannabinoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006640">
        <property type="term" value="P:monoacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007405">
        <property type="term" value="P:neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150077">
        <property type="term" value="P:regulation of neuroinflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098921">
        <property type="term" value="P:retrograde trans-synaptic signaling by endocannabinoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000015">
        <property type="entry name" value="Sn1-specific diacylglycerol lipase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 34" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 34" id="KW-0812">Transmembrane</keyword>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTM0</accession>
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        <submittedName>
            <fullName evidence="12">Actin binding LIM protein 1</fullName>
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        <name evidence="12" type="primary">ABLIM1</name>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <sequence length="789" mass="88880" checksum="59B6DA8E16821324" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HV22</accession>
    <name>A0A670HV22_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc finger protein 850</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HV22"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003807.1">
        <property type="protein sequence ID" value="ENSPMRP00000003553.1"/>
        <property type="gene ID" value="ENSPMRG00000002485.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="OMA" id="MEEDCID"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022603">
        <property type="term" value="P:regulation of anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000005">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001808">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001024">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001087">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000806">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="14">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="91909" checksum="5FC686C2B70CBC5E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HV25</accession>
    <name>A0A670HV25_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HV25"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003853.1">
        <property type="protein sequence ID" value="ENSPMRP00000003594.1"/>
        <property type="gene ID" value="ENSPMRG00000002512.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000208969"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF142">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF57.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="135" mass="14188" checksum="23E440CA5392522C" modified="2020-06-17" version="1">MGPAPHSAPSPLCFEDVAVCFTDKEWALLDPDQRALHKDVMEENWGIVASLGKPPCGIVLSARKFKTYLYWGKAALAPTASPTGSCDAFALLLDLGVWLLWAFAGDGGIPPPPAKAHGSSTLFKGCAAPAGFSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWG4</accession>
    <name>A0A670HWG4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Exostosin-like 3</fullName>
            <ecNumber evidence="22">2.4.1.223</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Multiple exostosis-like protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">EXTL3</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker. May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity). Lacks glucuronyl transferase II (GlcAT-II) activity. Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway. Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. Required for the inhibition of skin inflammation mediated by REG3A through the activation of PI3K-AKT-STAT3 pathway. Required for the function of REG3A and REG3G in glucose tolerance in pancreas. Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16221"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="Rhea" id="RHEA-COMP:12574"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="ChEBI" id="CHEBI:132104"/>
            <dbReference type="EC" id="2.4.1.223"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer; disulfide-linked. Interacts with REG3A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.223" evidence="22"/>
    <dbReference type="RefSeq" id="XP_028581046.1">
        <property type="nucleotide sequence ID" value="XM_028725213.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028581047.1">
        <property type="nucleotide sequence ID" value="XM_028725214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HWG4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003677.1">
        <property type="protein sequence ID" value="ENSPMRP00000003432.1"/>
        <property type="gene ID" value="ENSPMRG00000002417.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594927"/>
    <dbReference type="KEGG" id="pmua:114594927"/>
    <dbReference type="CTD" id="2137"/>
    <dbReference type="GeneTree" id="ENSGT00940000156692"/>
    <dbReference type="OMA" id="KFMGSHT"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001888">
        <property type="term" value="F:glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090594">
        <property type="term" value="P:inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900016">
        <property type="term" value="P:negative regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106015">
        <property type="term" value="P:negative regulation of inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045617">
        <property type="term" value="P:negative regulation of keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900017">
        <property type="term" value="P:positive regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000972">
        <property type="term" value="P:positive regulation of detection of glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010838">
        <property type="term" value="P:positive regulation of keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000033">
        <property type="entry name" value="Exostosin-like glycosyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF4">
        <property type="entry name" value="EXOSTOSIN LIKE GLYCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="26" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="28">
        <location>
            <begin position="192"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="29">
        <location>
            <begin position="663"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="79"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00066812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00074807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00079618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="919" mass="105162" checksum="12BEDED058253C22" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZV1</accession>
    <name>A0A670HZV1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cerebellin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CBLN4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
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    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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            <begin position="65"/>
            <end position="108"/>
        </location>
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            <end position="152"/>
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            <end position="198"/>
        </location>
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            <begin position="199"/>
            <end position="243"/>
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        </location>
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            <end position="431"/>
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        </location>
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            <begin position="484"/>
            <end position="526"/>
        </location>
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        <location>
            <begin position="527"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <end position="1757"/>
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            <end position="2356"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005879.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="2410" mass="264823" checksum="6A9320578DB43CFF" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I240</accession>
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        <recommendedName>
            <fullName evidence="2">Golgi associated RAB2 interactor protein-like Rab2B-binding domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the GARIN family.</text>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
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        </submittedName>
    </protein>
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            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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                <person name="Pinho C."/>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
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                <person name="Carneiro M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028724320.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000006262.1">
        <property type="protein sequence ID" value="ENSPMRP00000005887.1"/>
        <property type="gene ID" value="ENSPMRG00000003997.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114594515"/>
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    <dbReference type="GeneTree" id="ENSGT00390000003256"/>
    <dbReference type="OMA" id="NPWICQS"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF3">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="303" mass="32382" checksum="9B46D49681BC47FE" modified="2020-06-17" version="1">MLPGSIQISGETLSSAEIRDICESLRENSIKLLSLRGCQLSDRDFGRICRGVAESHSLAQLNLNLGIVSNINRVKQLAEALKTNRSVQSLFLHGSPLTDAGLALLNPALSIHPSLVALDLGDCMLGDEGINLICGLLPPDGAKSGLKELTLSANPGITAKGWGRLAIAVAHSSQVRVLNLDYNPLGDQIAGMLAVSVASSRTLEVLDLEGTGLTNQSALILLDMVENYPTALRTLILAENNISPELQQQISDLLSEGEEDDETETREVMAREKNNWICQSNSSSQMVLVTSGLGESLLAETEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3K6</accession>
    <name>A0A670I3K6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stromal cell-derived factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">C-X-C motif chemokine 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CXCL12</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intercrine alpha (chemokine CxC) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028584732.1">
        <property type="nucleotide sequence ID" value="XM_028728899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I3K6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006905.1">
        <property type="protein sequence ID" value="ENSPMRP00000006481.1"/>
        <property type="gene ID" value="ENSPMRG00000004381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596977"/>
    <dbReference type="KEGG" id="pmua:114596977"/>
    <dbReference type="CTD" id="6387"/>
    <dbReference type="GeneTree" id="ENSGT00390000014056"/>
    <dbReference type="OMA" id="HVAKSQI"/>
    <dbReference type="OrthoDB" id="9884353at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045236">
        <property type="term" value="F:CXCR chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038160">
        <property type="term" value="P:CXCL12-activated CXCR4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033622">
        <property type="term" value="P:integrin activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000669">
        <property type="term" value="P:negative regulation of dendritic cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902230">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903237">
        <property type="term" value="P:negative regulation of leukocyte tethering or rolling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000406">
        <property type="term" value="P:positive regulation of T cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904018">
        <property type="term" value="P:positive regulation of vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000010">
        <property type="entry name" value="Stromal cell-derived factor 1 precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF193">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00436">
        <property type="entry name" value="INTERLEUKIN8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="5" id="KW-0202">Cytokine</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025330319" description="Stromal cell-derived factor 1" evidence="11">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="12">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="94" mass="10834" checksum="D52A85101A048F8C" modified="2020-06-17" version="1">MDSKAAFLALLLLLGTLRAADGKPISLTYRCPCRYFESNVAKSHVKHLKILTVPGCSLQIIARLKNSSKQICLDPKLRWIQEYLEKYLHKRFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5G0</accession>
    <name>A0A670I5G0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">MAM domain containing glycosylphosphatidylinositol anchor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MDGA1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028580215.1">
        <property type="nucleotide sequence ID" value="XM_028724382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I5G0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007419.1">
        <property type="protein sequence ID" value="ENSPMRP00000006934.1"/>
        <property type="gene ID" value="ENSPMRG00000004724.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594547"/>
    <dbReference type="CTD" id="266727"/>
    <dbReference type="GeneTree" id="ENSGT00940000159201"/>
    <dbReference type="OMA" id="NSWQQAH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021799">
        <property type="term" value="P:cerebral cortex radially oriented cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904862">
        <property type="term" value="P:inhibitory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060134">
        <property type="term" value="P:prepulse inhibition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099054">
        <property type="term" value="P:presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099179">
        <property type="term" value="P:regulation of synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042428">
        <property type="term" value="P:serotonin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000240">
        <property type="entry name" value="MAM domain containing glycosylphosphatidylinositol anchor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000262">
        <property type="entry name" value="MAM domain containing glycosylphosphatidylinositol anchor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000303">
        <property type="entry name" value="MAM domain containing glycosylphosphatidylinositol anchor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000019">
        <property type="entry name" value="MAM domain containing glycosylphosphatidylinositol anchor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000165">
        <property type="entry name" value="MAM domain containing glycosylphosphatidylinositol anchor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000243">
        <property type="entry name" value="MAM domain-containing glycosylphosphatidylinositol anchor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
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    <dbReference type="InterPro" id="IPR050958">
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="MAM_dom"/>
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        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR45080:SF32">
        <property type="entry name" value="MAM DOMAIN CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
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        <property type="match status" value="6"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="6"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="MAM_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="49"/>
            <end position="148"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="157"/>
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        </location>
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    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="265"/>
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        <location>
            <begin position="661"/>
            <end position="760"/>
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        <location>
            <begin position="768"/>
            <end position="932"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50060"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="969" mass="108366" checksum="FAC5958BC94265CF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I686</accession>
    <name>A0A670I686_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transmembrane protein 59</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TMEM59</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="18">Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with ATG16L1 (via WD repeats).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="3">Single-pass type I membrane protein</topology>
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        <subcellularLocation>
            <location evidence="15">Late endosome membrane</location>
            <topology evidence="15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM59 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028733402.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A670I686"/>
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        <property type="protein sequence ID" value="ENSPMRP00000007189.1"/>
        <property type="gene ID" value="ENSPMRG00000004874.1"/>
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    <dbReference type="KEGG" id="pmua:114598965"/>
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    <dbReference type="GeneTree" id="ENSGT00390000008279"/>
    <dbReference type="OMA" id="MGCHNQL"/>
    <dbReference type="OrthoDB" id="6371519at2759"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:Golgi medial cisterna"/>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:Golgi trans cisterna"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:lysosomal membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Uncharacterised_TMEM59"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 59"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 59-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12280">
        <property type="entry name" value="BSMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025508586" description="Transmembrane protein 59" evidence="20">
        <location>
            <begin position="27"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004352"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="328" mass="36813" checksum="7E931A464030D144" modified="2020-06-17" version="1">MAALRPSRLGLGSLLLLLLLAVGDEAARPELEPVPESLSESFEPALGNTAPCQRTCQSTYPLHTYPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECDSACSEAYTSQSDEQYACRLGCQNQLPYAELRRDHLMSLMPRMHLLFPLTLVRSFWSDMMETAHSFITSSWTFYLQADDGKIVIFQSKPEVQFIESPGQETQDLKEPSFRKASLDLQPGGPQTHKGFFDEDESDNFFKCVSINSGWILTTTLVLSVLVLLWICCATVTTAVEQYVPSEKLSIYGDLEYMNEQKLNRYPTSALVVVKCKADEEEAGPLPTKVNLTQSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IA50</accession>
    <name>A0A670IA50_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptotagmin 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SYT15</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028584284.1">
        <property type="nucleotide sequence ID" value="XM_028728451.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028728452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IA50"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009349.1">
        <property type="protein sequence ID" value="ENSPMRP00000008750.1"/>
        <property type="gene ID" value="ENSPMRG00000005898.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596704"/>
    <dbReference type="KEGG" id="pmua:114596704"/>
    <dbReference type="CTD" id="83849"/>
    <dbReference type="GeneTree" id="ENSGT00940000160819"/>
    <dbReference type="OMA" id="DWIHLTN"/>
    <dbReference type="OrthoDB" id="10259057at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08390">
        <property type="entry name" value="C2A_Synaptotagmin-15-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08409">
        <property type="entry name" value="C2B_Synaptotagmin-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000101">
        <property type="entry name" value="Synaptotagmin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000237">
        <property type="entry name" value="Synaptotagmin 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047897">
        <property type="entry name" value="Synaptotagmin-15/17_C2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF234">
        <property type="entry name" value="SYNAPTOTAGMIN-15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="138"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="269"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="409" mass="46371" checksum="FB52FA32A30DD619" modified="2020-06-17" version="1">MSAQVAAVAGGVVGGILLLLLLGIAVYLFWKNVYFKASYEELTNPASPVQAPVHLQEPNVARTKSVPFIVPPKFHRQAWIDMINGEQIQEDSDLYVTPDSGPRSSFHSLAGAYLVGAINPELYRFPEDKSETDFPEGNIGRLWFSVEYEQESERLLVSLIKARKLQSPSSSCNPLVKIYLLPDERRYLQSKTKRKNLNPQFDENFVFQISSSALYQRTLKFCVYHVDKQKKHILLGQVIFPLKNESFTSEGKVIVWRDLEADTLELPSEHGDLQFSLSYNDYLGRLTVVVLRAKGLKLQNERHAVGVFVKVSLMKHNQFIKSKKTTVVPASSDPLYNETFSFKVDQQELDTASLSLSVLQDSEGEETSLGRVVVGPFMYTRGKELEHWNEMISKPKELVKRWHALSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IB39</accession>
    <name>A0A670IB39_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">COX11</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CNNM4/ACDP4. Interacts with RANBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IB39"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009497.1">
        <property type="protein sequence ID" value="ENSPMRP00000008888.1"/>
        <property type="gene ID" value="ENSPMRG00000005979.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007512"/>
    <dbReference type="OMA" id="NKLECFC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="249" mass="27428" checksum="5BCCF1760BD97A5C" modified="2020-06-17" version="1">MGGCARGWACLAAPAARGWGPWRAWLRLHGNGEAAACCGRRAKGGGGDPFAGARRRQQEDWRHRNKTVLTYLAAGVVGVAGMSYAAVPLYRLYCQATGLGGSAVAGHGSGEIETMVPVKDRIIKVTFNADVHASLQWNFRPQQTEVYVVPGETALAFYKAKNPTDKPIIGISTYNVVPFEAGQYFNKIQCFCFEEQRLNPHEEVDMPVFFFIDPEFAEDPRMANVDLITLSYTFFEAKEGQKLPLPGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICW4</accession>
    <name>A0A670ICW4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibroblast growth factor</fullName>
            <shortName evidence="8">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FGF3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028584504.1">
        <property type="nucleotide sequence ID" value="XM_028728671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ICW4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010120.1">
        <property type="protein sequence ID" value="ENSPMRP00000009489.1"/>
        <property type="gene ID" value="ENSPMRG00000006361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596867"/>
    <dbReference type="KEGG" id="pmua:114596867"/>
    <dbReference type="CTD" id="2248"/>
    <dbReference type="GeneTree" id="ENSGT00940000161128"/>
    <dbReference type="OMA" id="YHLQIHA"/>
    <dbReference type="OrthoDB" id="6158176at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055026">
        <property type="term" value="P:negative regulation of cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23315">
        <property type="entry name" value="beta-trefoil_FGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000060">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0339">Growth factor</keyword>
    <keyword evidence="7" id="KW-0497">Mitogen</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025710883" description="Fibroblast growth factor" evidence="8">
        <location>
            <begin position="18"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="238" mass="26624" checksum="9DB0723C5FB6610E" modified="2020-06-17" version="1">MVTAWLVLLSALQAARGSPGPAAADGAPVGPPCARGGPSCDPRWRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQIHANGRINGTLEKNSVFSILEITAVDVGIVAIKGCFSGRYLAMNKRGRLYASETYNAECEFVERIHELGYNTYASRIYRTVPNGASGRRKASAERLWYVSINGKGRPRRSFKTRRTQKSSLFLPRVLDNKDHDMVRLFHTNAKYRESLLKPPSKNQRRRRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEI3</accession>
    <name>A0A670IEI3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">26S proteasome non-ATPase regulatory subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSMD2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.</text>
    </comment>
    <comment type="function">
        <text evidence="1 8">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2. Interacts with RPGRIP1L. Interacts with CRY1 in a KDM8-dependent manner. Interacts (via C-terminus) with phosphatase UBLCP1 (via ubiquitin-like domain); the interaction recruits UBLCP1 to the 19S regulatory particle where it dephosphorylates 19S subunit PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587544.1">
        <property type="nucleotide sequence ID" value="XM_028731711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IEI3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010756.1">
        <property type="protein sequence ID" value="ENSPMRP00000010093.1"/>
        <property type="gene ID" value="ENSPMRG00000006742.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598060"/>
    <dbReference type="KEGG" id="pmua:114598060"/>
    <dbReference type="CTD" id="5708"/>
    <dbReference type="GeneTree" id="ENSGT00940000153386"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="10">
        <location>
            <begin position="64"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="11">
        <location>
            <begin position="861"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="916" mass="100701" checksum="DFB43CB6923975E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEY2</accession>
    <name>A0A670IEY2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3 11"/>
    <dbReference type="AlphaFoldDB" id="A0A670IEY2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010929.1">
        <property type="protein sequence ID" value="ENSPMRP00000010259.1"/>
        <property type="gene ID" value="ENSPMRG00000006836.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165782"/>
    <dbReference type="OMA" id="QKLCACH"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF19">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="185" mass="20867" checksum="3FD75BDA1C9BF122" modified="2020-06-17" version="1">MLRRRNLLTTLLIALPWGLLLTLWHQYPTTRYLSILRKETDENVKAKSLFNNSTPLTREDGLSSCARQPAVGAAPKAIRSYVYSRPPPWSEALPSIFVITPTYSRPVQKAELTRLANTFLHVQNLHWVVVEDAPRRTNLVSNLLEKTGINFTHLNVETPKSLKTLSGSHLKKQGARCRGILDCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IH52</accession>
    <name>A0A670IH52_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IH52"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011385.1">
        <property type="protein sequence ID" value="ENSPMRP00000010672.1"/>
        <property type="gene ID" value="ENSPMRG00000007093.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014405"/>
    <dbReference type="OMA" id="PRICKAF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000059">
        <property type="entry name" value="Phosphatidylinositol glycan anchor biosynthesis class A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="237" mass="26591" checksum="D0D6E893501DE386" modified="2020-06-17" version="1">IDLLSGIIPELCQKYPDLHFLVGGEGPKRIVLEEVRERYQLHDRVRLLGALEHQDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPDNFIILCEPSVKSLCNGLEKAIRQLKSGSLLSSEIIHNNVKTFYTWKDVAKRTEKVYDRVAGETVLPMGKRLDRLISHCGPVTGCIFALFAVLSFLFLILLRWLTPDYLIDVAINATGENGAWTRQYFPNKNKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJT4</accession>
    <name>A0A670IJT4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen type IX alpha 2 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">COL9A2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IJT4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013113.1">
        <property type="protein sequence ID" value="ENSPMRP00000012285.1"/>
        <property type="gene ID" value="ENSPMRG00000008217.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161290"/>
    <dbReference type="OMA" id="CDISPAH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005594">
        <property type="term" value="C:collagen type IX trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="631" mass="62707" checksum="DADF153A18F51512" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IK17</accession>
    <name>A0A670IK17_PODMU</name>
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        <recommendedName>
            <fullName evidence="14">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">UNC5A</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028574282.1">
        <property type="nucleotide sequence ID" value="XM_028718449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IK17"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012795.1">
        <property type="protein sequence ID" value="ENSPMRP00000011981.1"/>
        <property type="gene ID" value="ENSPMRG00000008007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591432"/>
    <dbReference type="KEGG" id="pmua:114591432"/>
    <dbReference type="CTD" id="90249"/>
    <dbReference type="GeneTree" id="ENSGT00950000182815"/>
    <dbReference type="OMA" id="QKSACTT"/>
    <dbReference type="OrthoDB" id="5973910at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033564">
        <property type="term" value="P:anterior/posterior axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000001">
        <property type="entry name" value="Unc-5 netrin receptor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000002">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000008">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000003">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000037">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000039">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033772">
        <property type="entry name" value="UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF4">
        <property type="entry name" value="NETRIN RECEPTOR UNC5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17217">
        <property type="entry name" value="UPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 14" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025713003" description="Netrin receptor UNC5" evidence="14">
        <location>
            <begin position="37"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="166"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="16">
        <location>
            <begin position="507"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="908" mass="100049" checksum="BF97BE7F35ACE741" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IM80</accession>
    <name>A0A670IM80_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the venom waprin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IM80"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013663.1">
        <property type="protein sequence ID" value="ENSPMRP00000012793.1"/>
        <property type="gene ID" value="ENSPMRG00000008557.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000013666.1">
        <property type="protein sequence ID" value="ENSPMRP00000012796.1"/>
        <property type="gene ID" value="ENSPMRG00000008557.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000210349"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050514">
        <property type="entry name" value="WAP_four-disulfide_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441:SF95">
        <property type="entry name" value="PERLWAPIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441">
        <property type="entry name" value="WHEY ACDIC PROTEIN WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
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    </dbReference>
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        <location>
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            <end position="24"/>
        </location>
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            <end position="151"/>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>A0A670IN19_PODMU</name>
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        <submittedName>
            <fullName evidence="17">Lymphocyte antigen 75</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LY75</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="ENSPMRG00000008837.1"/>
    </dbReference>
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    <dbReference type="OMA" id="YHEIYTK"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000066">
        <property type="entry name" value="Lymphocyte antigen 75"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="lymphocyte antigen 75 precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lymphocyte antigen 75 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
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    </dbReference>
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        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
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        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
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        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24562">
        <property type="entry name" value="CysR_MRC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
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    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
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    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="1649"/>
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            <begin position="157"/>
            <end position="205"/>
        </location>
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        <location>
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            <end position="335"/>
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    </feature>
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        <location>
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            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
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            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
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            <end position="750"/>
        </location>
    </feature>
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        <location>
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            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="1063"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="1204"/>
            <end position="1336"/>
        </location>
    </feature>
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        <location>
            <begin position="1354"/>
            <end position="1459"/>
        </location>
    </feature>
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        <location>
            <begin position="1497"/>
            <end position="1608"/>
        </location>
    </feature>
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        <location>
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            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000472272"/>
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    <sequence length="1682" mass="194002" checksum="0968DAEA0F823408" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INR2</accession>
    <name>A0A670INR2_PODMU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="primary">HPS3</name>
    </gene>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029438">
        <property type="entry name" value="HPS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029437">
        <property type="entry name" value="HPS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28633:SF1">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28633">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14763">
        <property type="entry name" value="HPS3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14761">
        <property type="entry name" value="HPS3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-2 complex member HPS3 N-terminal" evidence="2">
        <location>
            <begin position="66"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="BLOC-2 complex member HPS3 C-terminal" evidence="3">
        <location>
            <begin position="566"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1070" mass="120140" checksum="71C096ED310796D8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IPV4</accession>
    <name>A0A670IPV4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial ribonuclease P catalytic subunit</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mitochondrial ribonuclease P protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PRORP</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028576544.1">
        <property type="nucleotide sequence ID" value="XM_028720711.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028576553.1">
        <property type="nucleotide sequence ID" value="XM_028720720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IPV4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014650.1">
        <property type="protein sequence ID" value="ENSPMRP00000013711.1"/>
        <property type="gene ID" value="ENSPMRG00000009184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592527"/>
    <dbReference type="KEGG" id="pmua:114592527"/>
    <dbReference type="CTD" id="9692"/>
    <dbReference type="GeneTree" id="ENSGT00390000002201"/>
    <dbReference type="OMA" id="VKEPIRY"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030678">
        <property type="term" value="C:mitochondrial ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18718">
        <property type="entry name" value="PIN_PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000003">
        <property type="entry name" value="Mitochondrial ribonuclease P catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033495">
        <property type="entry name" value="MRPP3_PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRORP" evidence="16">
        <location>
            <begin position="343"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="583" mass="66763" checksum="A6048CBBBFA24592" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQC0</accession>
    <name>A0A670IQC0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Coagulation factor XI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">F11</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IQC0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014840.1">
        <property type="protein sequence ID" value="ENSPMRP00000013886.1"/>
        <property type="gene ID" value="ENSPMRG00000009312.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158569"/>
    <dbReference type="OMA" id="TAMYTPN"/>
    <dbReference type="OrthoDB" id="9448935at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035821">
        <property type="term" value="P:modulation of process of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031639">
        <property type="term" value="P:plasminogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051919">
        <property type="term" value="P:positive regulation of fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF17">
        <property type="entry name" value="SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00005">
        <property type="entry name" value="APPLEDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
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    </dbReference>
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    <keyword evidence="3" id="KW-0964">Secreted</keyword>
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        </location>
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        </location>
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        </location>
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            <end position="192"/>
        </location>
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            <begin position="280"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="624" mass="70487" checksum="7AAE830EF0CF68D9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
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                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVV0</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP1 inhibitor family.</text>
    </comment>
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        <property type="gene ID" value="ENSPMRG00000010615.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPI-17_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
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        <location>
            <begin position="1"/>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <end position="146"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="146" mass="15986" checksum="FFE392695058916D" modified="2020-06-17" version="1">MAANRVGRRLGRASPARPAGLSPGGGRAAERTPSPGIQRRQARVTVKYDRRELQRRLDTEKWIDGRLEELYRGQEAEMPDEVNIDNLLEMAADEERAKKLQVGAGGCCPPPPRASQPGCSQGRELGSSFRGGGHCEKRTLERVGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IW36</accession>
    <name>A0A670IW36_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Stanniocalcin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STC2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Has an anti-hypocalcemic action on calcium and phosphate homeostasis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the stanniocalcin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028573589.1">
        <property type="nucleotide sequence ID" value="XM_028717756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IW36"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017264.1">
        <property type="protein sequence ID" value="ENSPMRP00000016175.1"/>
        <property type="gene ID" value="ENSPMRG00000010807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591086"/>
    <dbReference type="KEGG" id="pmua:114591086"/>
    <dbReference type="CTD" id="8614"/>
    <dbReference type="GeneTree" id="ENSGT00390000005989"/>
    <dbReference type="OMA" id="HNSKATH"/>
    <dbReference type="OrthoDB" id="8931566at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040015">
        <property type="term" value="P:negative regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046885">
        <property type="term" value="P:regulation of hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004978">
        <property type="entry name" value="Stanniocalcin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245">
        <property type="entry name" value="STANNIOCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245:SF2">
        <property type="entry name" value="STANNIOCALCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03298">
        <property type="entry name" value="Stanniocalcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025677647" description="Stanniocalcin-2" evidence="10">
        <location>
            <begin position="26"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="301" mass="33366" checksum="8A5CE709389616FA" modified="2020-06-17" version="1">MHAAEWLGKFVTLALVFASLDPVVGTEATNPPDGAQDNRAPQQKGRLSLQNTAEIQHCLVNAGDVGCSVFECFENNSCEIRGLHEICMTFLHNAGKFDAQGKSFIKDALRCKAHALRHKFSCISRKCPAIKEMVLQLQRECYQKHDLCSAAKENVQVMVEMIHFKDLLQHEPYVDLVNTLLTCGEEVREAITRSVQAQCEQSWGSLCSILSFCTSVPHGDFTLEPEKKPNEVPRSSISQGDIIVHPEPDARESSRNTRGERGSRLPGNAQTRTKAGSHSPKAAHGIVEQAEELSDFSDIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWT8</accession>
    <name>A0A670IWT8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114593728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028578206.1">
        <property type="nucleotide sequence ID" value="XM_028722373.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578207.1">
        <property type="nucleotide sequence ID" value="XM_028722374.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578208.1">
        <property type="nucleotide sequence ID" value="XM_028722375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IWT8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016692.1">
        <property type="protein sequence ID" value="ENSPMRP00000015632.1"/>
        <property type="gene ID" value="ENSPMRG00000010433.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593728"/>
    <dbReference type="KEGG" id="pmua:114593728"/>
    <dbReference type="GeneTree" id="ENSGT00940000154526"/>
    <dbReference type="OMA" id="PHEDMES"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03208">
        <property type="entry name" value="GST_C_Alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000005">
        <property type="entry name" value="Glutathione S-transferase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003080">
        <property type="entry name" value="GST_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF107">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01266">
        <property type="entry name" value="GSTRNSFRASEA"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="217" mass="24998" checksum="F4BC142E93132A3C" modified="2020-06-17" version="1">MAGKPKLYYFNGRGRMESIRWLLAAAGVEFEEQLIETKEDLEKLKHGGDLLFQQVPMVEMDGMKMVQTRAILNYIAAKYNLYGKDVKQRALIDMYCEGAMDLNELKKMLHFKPADSKEKEFANVIEKATTRYFPVFEKVLKDHGQNYLVGNQLSRADIQLLETILMAEELKADILSKFPLLKAFKERISNIPTVKKYLQPGSQRRPPADEKAMKIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWW7</accession>
    <name>A0A670IWW7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A670IWW7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017384.1">
        <property type="protein sequence ID" value="ENSPMRP00000016286.1"/>
        <property type="gene ID" value="ENSPMRG00000010880.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017837"/>
    <dbReference type="OMA" id="EICNEVY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF7">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="12">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="13">
        <location>
            <begin position="155"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="350" mass="40925" checksum="21CBE4FEFCC2DA05" modified="2020-06-17" version="1">MWTTTDYAFLSWFLQLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVISSKKLVGFISAIPAAIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTPGLRPMEQRDIPAVHKLLAEYLKLFNLTPVMNEEEVDHWFLPQPNIIDTFVVENTDGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTKTPLLDLMNDALILAKMRGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGPEKVVLVLQELKELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IX31</accession>
    <name>A0A670IX31_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="16">LTA-4 hydrolase</shortName>
            <ecNumber evidence="16">3.3.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LTA4H</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>leukotriene A4 + H2O = leukotriene B4</text>
            <dbReference type="Rhea" id="RHEA:22324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="EC" id="3.3.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Lipid metabolism; leukotriene B4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.6" evidence="16"/>
    <dbReference type="RefSeq" id="XP_028603469.1">
        <property type="nucleotide sequence ID" value="XM_028747636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IX31"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017110.1">
        <property type="protein sequence ID" value="ENSPMRP00000016029.1"/>
        <property type="gene ID" value="ENSPMRG00000010705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605927"/>
    <dbReference type="KEGG" id="pmua:114605927"/>
    <dbReference type="CTD" id="4048"/>
    <dbReference type="GeneTree" id="ENSGT00940000156375"/>
    <dbReference type="OMA" id="CTALQWM"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="UniPathway" id="UPA00878"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004463">
        <property type="term" value="F:leukotriene-A4 hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019370">
        <property type="term" value="P:leukotriene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000002">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
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    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
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    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 16" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="462"/>
            <end position="606"/>
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        <location>
            <position position="295"/>
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        <location>
            <begin position="133"/>
            <end position="135"/>
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        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="265"/>
            <end position="270"/>
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        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="294"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="298"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="562"/>
            <end position="564"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="618" mass="69991" checksum="50ED42AB01AC8185" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZ73</accession>
    <name>A0A670IZ73_PODMU</name>
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            <fullName evidence="13">Coiled-coil-helix-coiled-coil-helix domain containing 6</fullName>
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            <taxon>Laterata</taxon>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0175">Coiled coil</keyword>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
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</entry>
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    <accession>A0A670IZA9</accession>
    <name>A0A670IZA9_PODMU</name>
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        <recommendedName>
            <fullName evidence="6">TBC1 domain family member 20</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="8">
        <location>
            <begin position="57"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="398" mass="45050" checksum="555A94A458E123EC" modified="2020-06-17" version="1">LAVREPSEGPQSWTSASGQNDGGGDKKQKRLLIHQALTRDPVDVESLRAAALSQGGLLTDEIRRKVWPKLLGVNVYSLPPKPGREVRQNHKDCHQVLLDVRRSIRRFPPGMQEEQRQALQEQLTDIILHVLKTHPDLHYYQGYHDIAVTLLLVSGERMAVALLERLSTLHLRDFMDPTMDSTKHILNYLMPILQQESPRLHDFMQRAEVGTIFALSWLITWYGHVLANFQHILRLYDFFLASHPLMAVYFAAAIVLFREEEVLACDCDMPSIHQLLSQIPQDLPYETLIARAHQLFQRLPHAQLAKQAALQLQKREETAAFQQAASCQRPDAILRQQQQQRHLTTSKAEEAGELLPAAEHSPLVKAAVWGISATLGAAALAVTQTALEWAPEFLLQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZW2</accession>
    <name>A0A670IZW2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Doublecortin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IZW2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018637.1">
        <property type="protein sequence ID" value="ENSPMRP00000017505.1"/>
        <property type="gene ID" value="ENSPMRG00000011567.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162396"/>
    <dbReference type="OMA" id="YIHIAPR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004">
        <property type="entry name" value="DOUBLECORTIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004:SF9">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="270" mass="30880" checksum="D3ABED187C318595" modified="2020-06-17" version="1">MLIPPVKILLPKFTLKSWNGVLGLINEKVSSRSGGIHRLFTLNGQSVHGSDELEHNHFYVACGKEKFQPLPYWQHPRVPEDIRRYNSNTPGPLEGPPPKKPPTERAKRGAGMQPAIPPSKRGAGDRSSVYYAEPKKASRGAEANKHLTSDDGRGVYKARTPPEEIKEAQQIQEDKNLQVEVPVDQAPAEVVHDEDIYANWSTEEEAEDYYQDVKPEKKERKGVFKKMFGFFFRSKKKDQNEEANEDSRKLDTKKPYYDKKNEDFDAYDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J164</accession>
    <name>A0A670J164_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">UBE2S</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670J164"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019090.1">
        <property type="protein sequence ID" value="ENSPMRP00000017940.1"/>
        <property type="gene ID" value="ENSPMRG00000011835.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157149"/>
    <dbReference type="OMA" id="RMIQEPQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010994">
        <property type="term" value="P:free ubiquitin chain polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044314">
        <property type="term" value="P:protein K27-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035519">
        <property type="term" value="P:protein K29-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000034">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="192" mass="21013" checksum="DD52EA25AE56B3D7" modified="2020-06-17" version="1">EVSTLTSDPPEGIKVFPNEEDITDVQVTIEGPEGTPYSGGLFRMKLILGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLKKDWKAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYASRARLLTEIHAQPSSGLRTKDPAEPCSSSAGASGEGPMAKKHAGDRDKKLASKKKTDKKRALRRL</sequence>
</entry>
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        </submittedName>
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        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Laterata</taxon>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    <dbReference type="OMA" id="HHSWENE"/>
    <dbReference type="OrthoDB" id="9948620at2759"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042583">
        <property type="term" value="C:chromaffin granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Chromogranin_AB"/>
    </dbReference>
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        <property type="entry name" value="CHROMOGRANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J362</accession>
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        <submittedName>
            <fullName evidence="4">FHF complex subunit HOOK interacting protein 2B</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">FHIP2B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
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    </dbReference>
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    </dbReference>
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            <end position="54"/>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3M5</accession>
    <name>A0A670J3M5_PODMU</name>
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        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
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                <person name="Marsik P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THAP_Znf"/>
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        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="108" mass="12226" checksum="46014480031DE139" modified="2020-06-17" version="1">MPKACSAVNCPNRDTRENRAKGLSFHSFPKAHELRKKWMLAVNRIEPGSRKLWIPGSGACICSDHFFQDDFEVYGGQKRLKAGVIPSVFSFKVSQCQKREESPCTHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4Q6</accession>
    <name>A0A670J4Q6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CYB561D1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A670J4Q6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019709.1">
        <property type="protein sequence ID" value="ENSPMRP00000018544.1"/>
        <property type="gene ID" value="ENSPMRG00000012176.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000038072"/>
    <dbReference type="OMA" id="SDWFQAT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF9">
        <property type="entry name" value="TRANSMEMBRANE REDUCTASE CYB561D1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
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    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="12"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="221" mass="24472" checksum="A07855318023F9B6" modified="2020-06-17" version="1">MLGAPASAERRALRWLRRGCGVLAHLAALGTTALLLLLSRPGTSLFSWHPAFMSIAFCLCLTEAILIFSPEGLLFCSCSHKTKVQLHWTAQTLALVAATLGLAFIVSSKNRSELPHLVSWHSVLGLLTLLAACGQVLCGFCLRFPRLLRISSVGRLRLVHMIYGLIVYLLATFTVALGIYSDWFQAQIKGVAWYFCLGLPFCPALVILKQITRTRKKRQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4T4</accession>
    <name>A0A670J4T4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Neuropilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">NRP1</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the neuropilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028606857.1">
        <property type="nucleotide sequence ID" value="XM_028751024.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028606858.1">
        <property type="nucleotide sequence ID" value="XM_028751025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J4T4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019444.1">
        <property type="protein sequence ID" value="ENSPMRP00000018282.1"/>
        <property type="gene ID" value="ENSPMRG00000012037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607641"/>
    <dbReference type="KEGG" id="pmua:114607641"/>
    <dbReference type="CTD" id="8829"/>
    <dbReference type="GeneTree" id="ENSGT00940000157169"/>
    <dbReference type="OMA" id="QEDCTKP"/>
    <dbReference type="OrthoDB" id="6155811at2759"/>
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        <property type="component" value="Chromosome 12"/>
    </dbReference>
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        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038085">
        <property type="term" value="F:vascular endothelial growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005021">
        <property type="term" value="F:vascular endothelial growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035729">
        <property type="term" value="P:cellular response to hepatocyte growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035767">
        <property type="term" value="P:endothelial cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048012">
        <property type="term" value="P:hepatocyte growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048008">
        <property type="term" value="P:platelet-derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010595">
        <property type="term" value="P:positive regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="220" mass="23489" checksum="054196AE235FA8C7" modified="2020-06-17" version="1">PSQTFPRRPRTPSGAWTGACPAPRGAAAGSEAEKVVHSRSQALLFLGGGTKALGDAFKLLVPKSTEFMSSDAELWNFLCSLKHQFSPVILRSKDVYGYASCRASVPDLSRALQRRSRGCPRRSRRAPRAAAAAAGGRGAAAAAAIGCRPGSGRSLESIWQAATPRQPDSFPSVKVRGSVWNRRSLEAARRRARRLLGVDLAPVVRLRRLPLVGRRGAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J868</accession>
    <name>A0A670J868_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sugar phosphate exchanger 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 37 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SLC37A3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028602978.1">
        <property type="nucleotide sequence ID" value="XM_028747145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J868"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021087.1">
        <property type="protein sequence ID" value="ENSPMRP00000019854.1"/>
        <property type="gene ID" value="ENSPMRG00000012948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605670"/>
    <dbReference type="KEGG" id="pmua:114605670"/>
    <dbReference type="CTD" id="84255"/>
    <dbReference type="GeneTree" id="ENSGT00940000165554"/>
    <dbReference type="OMA" id="YQWQVFL"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006855">
        <property type="term" value="P:xenobiotic transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17342">
        <property type="entry name" value="MFS_SLC37A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000028">
        <property type="entry name" value="Sugar phosphate exchanger 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000132">
        <property type="entry name" value="sugar phosphate exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="25"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="509" mass="55677" checksum="08F8A5D489EF4009" modified="2020-06-17" version="1">MPGVRRRPPANRTLTSQCTHHHVAVFLLTFFSYSLLHASRKTFSNVKVSISNQWTPFPHNNTSPSLQPNELWNNGHIFPDTRKATLFLGTLDTIFLFSYAVGLFISGIVGDRLNMRWVLSFGMCSSAVVVFVFGTVTEWLHFYNKWFYCFLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGLVFGLWSACASVGNIFGAFLASSVLQYGYEYAFLVTASVQFAGGIIVFFGLVISPKEVGLPDVGEEGDGSAEEDVSEPLIGSSDDNDDNDDQNYSIQAADLSNSGSSSNARQPKAIGFFQACCLPGVILYSLAYACLKLVNYSFFFWLPLYLYDNFGWKEAEADELSIWYDVGGIIGGTIQGFISDKLQKRAPVLAVSLILAIASLLGYSRSPNDKLINAVLMAITGFFIGGPSNMISSAISADLGRQEMVKGSSEALATVTGIVDGTGSIGAAVGQSLVSLIHDKLEWMSVFYFFSLMIGLTVLFITPLIVNEIKMLRAERRLRRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J9W4</accession>
    <name>A0A670J9W4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J9W4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022279.1">
        <property type="protein sequence ID" value="ENSPMRP00000020980.1"/>
        <property type="gene ID" value="ENSPMRG00000013644.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234712"/>
    <dbReference type="OMA" id="AKHAKGW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="342"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="796" mass="90911" checksum="F51FFB910D9E0DC9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBG9</accession>
    <name>A0A670JBG9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome 3 open reading frame 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">C3orf49</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBW0</accession>
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        <submittedName>
            <fullName evidence="3">Methyltransferase like 21E, pseudo</fullName>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Andersson L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <sequence length="190" mass="21732" checksum="487CFE9DB3C61E26" modified="2020-06-17" version="1">MKKEKYALAGRKLVVLQLPAKADKGSDLTEFSLANFTGKLSFILWPLPATGARVVATDLPELLGNLQYNLVKNTKTKCKHEPQAKELFWGVDLEKNFPRASCQFDYILAADVVYHHPYLNELLLTFDHLCKDNTIIIWAMRFRLEKENQFVPTKTGDGRVHYPDEWWHVSCQTRNGVTSLPQLGVSSKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JD37</accession>
    <name>A0A670JD37_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor EB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TFEB</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MiT/TFE family.</text>
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    </dbReference>
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        <property type="gene ID" value="ENSPMRG00000013677.1"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:antibacterial innate immune response"/>
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        <property type="term" value="P:humoral immune response"/>
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        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="entry name" value="microphthalmia-associated transcription factor isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
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        <property type="entry name" value="MIP04163P"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11851">
        <property type="entry name" value="DUF3371"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="228"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="461" mass="52130" checksum="2BA87308C50DAFF4" modified="2020-06-17" version="1">MASRIGLRMQLMREQVQQEEQRERMQQQAMMHYMQQQQQMPMAPTPAINTPVHFQSPPSVPGEVLKVQSFLENPTTYHLQRSRDKKVQEFLSETYGNKFAPLLSAPSPKPPPSVSPGVRPSHVMPSSAGNSTPNSPMAMLNIGSNPEREIDDVIEDIMQLTTTVGCINPEIHMPNTLPLSSSHMNVYSSDLQMTPSVVGMTSSSCPADLTQKRELTDAENRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKAGDLDVRWNKGTILKASVDYIRRMQKDLQRSRDLENHSRHLEMANKQLWLRIQELEMQARVHGLPTASPSGLNMAELAQQVVKQETPGEEDTTEIQPPPQPPLHPEQEAQQHQLHFAPPQSPYHQLDFTHGLSFDDNSRGFHDPLDPSQNVSFPSLSKKELDLMLMEDTMLPMASDPLFSAVSPEASKASSRRSSFSMEDTDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JDF6</accession>
    <name>A0A670JDF6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JDF6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023792.1">
        <property type="protein sequence ID" value="ENSPMRP00000022396.1"/>
        <property type="gene ID" value="ENSPMRG00000014543.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165291"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025503846" evidence="1">
        <location>
            <begin position="22"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="408" mass="46115" checksum="9E36855CA41C51BF" modified="2020-06-17" version="1">MHMLDINMILLLILIPWEGEGSLNLTKFAKYGFSHDHNMWVGLAEMVANVANRTNCLVCSLGPDDSEGGMPLLPIPLDAIGMVSEMPHQTEIQNFPGWNSTKPLRVIPVQGEFCVHKSSDAADSTMIGSSHCHYTWDYFKNSHTWAHGTTYRTRNTLPCAPPFIHAWKVVWNITVTEKGNLTYCTVNSLPLLVFRLLYSTYQKPQTRWLWWICGEWAYKKLPSKWSGTCFLGWVLPPMWIMPTSSAKRTRRNADISRIAGGSTQSWSGTDDWPPERIIAYYDPASWNPGELIQGARDPIYNLNRIIRLQAVVELVTNATAQSLRLIAQQLDESRATILQLKMGMDYVLARQGGLCGVLNLTGNACCFNISDNGEAIRVLATKMENIAHVPVQTWEGWDMGWLTNWLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JE31</accession>
    <name>A0A670JE31_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JE31"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022711.1">
        <property type="protein sequence ID" value="ENSPMRP00000021397.1"/>
        <property type="gene ID" value="ENSPMRG00000013886.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162989"/>
    <dbReference type="OMA" id="MVWTLGM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF248">
        <property type="entry name" value="CHITOTRIOSIDASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="56"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="421" mass="46393" checksum="AE59638198DB61FB" modified="2020-06-17" version="1">MELLSLLLPVVPLTPSPKIQKIGRTARADMGDSEGQGGEKGFISQTGVILLVRSAYKLVCYVTNWEQYRDPPAKFTPDNIDPHLCTHVIYAFAGMDNNRLTTIEWNDVELYKKLNALKQRNNKLLTLLAVGGGSFDNQKFTSMISSPANRQTFATTSIDFLRKHGFDGMDLDWEYPGSKGSPAEDKHRFTILTQELIAAFEEEGKRTGRPRLLLSAAVSASKNTMDAGYEVAALGKSLDLINVMTYDFHGSWAPQTGHNSPLHRGAPSYDSTPFFNSEYAMKYWKDNGAPAEKLMMGFPTYGQSFKLASSRTDVGAPASGGGSPGQYTKASGILAYYEVCPFLKGATKGWIEEQKVPYAFKAGDWVGYDDEKSFQFKAEFLKRENYGGAMVWTLGMDDFSGKFCGQGANVLVNKLKGLLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEU3</accession>
    <name>A0A670JEU3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JEU3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023489.1">
        <property type="protein sequence ID" value="ENSPMRP00000022114.1"/>
        <property type="gene ID" value="ENSPMRG00000014387.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162777"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
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        <property type="entry name" value="Trypsin_dom"/>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
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        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="175" mass="19455" checksum="4D8AD09E507073AD" modified="2020-06-17" version="1">NWLLLLMRIMGSSDVLPGTWPWTVSIQTKGQGKVYIHSCGGSLIGPQWVLSAGHCFRSLTLLWTLVGPMNLFFPSRLRKVFKVVVGITKLSQPGPDAQQRRIKRVVDYKLYEDDESLRYGLSVVELVEPVRCSDYVQPACLPDDSVVLSMLTHCYISGWGDMGEESEKGPGPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JF31</accession>
    <name>A0A670JF31_PODMU</name>
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        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JF31"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024429.1">
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        <property type="gene ID" value="ENSPMRG00000014934.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="94" mass="10678" checksum="1A3266655901D52A" modified="2020-06-17" version="1">MNNLTFTSGFLLLEFSQIRELQILHFLVFLGLYLITVIGNLLIIFLIALDHHLHTPMYFFLMNLAVSDIVSVIQPKSMVTFFSFSSLGALILPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JF95</accession>
    <name>A0A670JF95_PODMU</name>
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        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">OR6J1</name>
    </gene>
    <organism evidence="15 16">
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JF95"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023137.1">
        <property type="protein sequence ID" value="ENSPMRP00000021802.1"/>
        <property type="gene ID" value="ENSPMRG00000014157.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01090000260086"/>
    <dbReference type="OMA" id="CATHLTM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047132">
        <property type="entry name" value="Olfact_rcpt_6C-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454:SF53">
        <property type="entry name" value="OLFACTORY RECEPTOR 6J1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="41"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="324" mass="36575" checksum="8DBFC4D35C6A9488" modified="2020-06-17" version="1">MPYANSSAVREFYLVGFPTEPSTQLLLFFLVLTNYLITLSGNTVIICITLSDHRLQSPMYFFLRNFSFAEIWFTTVTVPKLLAGFLWGSHTISFVGCMTQCYFYFLLGATEFLLLGVMSFDRYQAVCNPLRYPALMTRNQACIQMLVGSWLGGFLSVLFPTILITRLSFCRSNVINHFFCDSGPLLELSCSDTSFIELMDFFLSAVVIICSLTVTLFSYMFIISAVMHISSTTGRAKAFNTCASHLTIISISCSISIFIYVTPSQKETLEVHKVPATIVCPFLNPFIFTLKNDTVKQALKDVLRQYKVLVTQKAWGSLQKKRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JG77</accession>
    <name>A0A670JG77_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Adhesion molecule with Ig like domain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">AMIGO2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220. Interacts with PTPRS. Interacts with MAPK8IP3/JIP3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. AMIGO family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028602958.1">
        <property type="nucleotide sequence ID" value="XM_028747125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JG77"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024903.1">
        <property type="protein sequence ID" value="ENSPMRP00000023461.1"/>
        <property type="gene ID" value="ENSPMRG00000015217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605657"/>
    <dbReference type="KEGG" id="pmua:114605657"/>
    <dbReference type="CTD" id="347902"/>
    <dbReference type="GeneTree" id="ENSGT00950000183146"/>
    <dbReference type="OMA" id="DFVWVGP"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031283">
        <property type="entry name" value="AMIGO"/>
    </dbReference>
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        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24368">
        <property type="entry name" value="AMPHOTERIN-INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24368:SF209">
        <property type="entry name" value="AMPHOTERIN-INDUCED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025694125" evidence="16">
        <location>
            <begin position="35"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="297"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="424"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="516" mass="57759" checksum="01604E75C95A008F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JGE6</accession>
    <name>A0A670JGE6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Bromodomain and PHD finger containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BRPF3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028733978.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028589812.1">
        <property type="nucleotide sequence ID" value="XM_028733979.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028589813.1">
        <property type="nucleotide sequence ID" value="XM_028733980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JGE6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024964.1">
        <property type="protein sequence ID" value="ENSPMRP00000023521.1"/>
        <property type="gene ID" value="ENSPMRG00000015249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599207"/>
    <dbReference type="KEGG" id="pmua:114599207"/>
    <dbReference type="CTD" id="27154"/>
    <dbReference type="GeneTree" id="ENSGT00940000155056"/>
    <dbReference type="OMA" id="XRSLLMP"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043997">
        <property type="term" value="F:histone H4K12 acetyltransferase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043995">
        <property type="term" value="F:histone H4K5 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043996">
        <property type="term" value="F:histone H4K8 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    </evidence>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="306" mass="34209" checksum="97E92A0A1A345068" modified="2020-06-17" version="1">MVSKYKDMAACVKCPEDEYPNHDQTQCIPKVPSYLSYEEDLGLILVILTISFSLVTTFILGTFMKHNNTPIVKANNRTLTYILLISLLLCFLCSFLFIGQPGKVTCLLRQITFSIIFSVALSSVLAKTITVLLAFMATKPGSRMRKWIGKRLANSIILFCSFIQASLGTLWLSTSPPFPDTDMHSLHGEIILECNEGSVAMFYGVLVYMGLLAIVSFILAFLARKLPDSFNEAKFITFSLLVFCSVWLSFVPTYLSTKGKYMVAVEIFSILSSGAGLLACIFSPKCYIIIFRPELNTREILISRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JIZ3</accession>
    <name>A0A670JIZ3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Armadillo repeat-containing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JIZ3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024995.1">
        <property type="protein sequence ID" value="ENSPMRP00000023549.1"/>
        <property type="gene ID" value="ENSPMRG00000015264.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003856"/>
    <dbReference type="OMA" id="WDTELHV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006911">
        <property type="entry name" value="ARM-rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042834">
        <property type="entry name" value="Armc12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47144">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47144:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04826">
        <property type="entry name" value="Arm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Armadillo repeat-containing" evidence="1">
        <location>
            <begin position="96"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="331" mass="37682" checksum="7CC4F4611F5A5DC5" modified="2020-06-17" version="1">MLPMSKHMLLHLVRHAPFSSPITALFASLPPSGPLAFLPFLCLELAIEHQSQTVLDSGELRGLLNTLNPKLDDYSKNMLLHGITRCVYLLDNEASACTYEDIKLVASFLDDPDIGIKIQTLHALKAFTGIWKFRIRIQEFFPKVLEMVASIWDHDLHAAGLRLLNGLPLSDHTFPLVKKLMPAFMEILQMGNTLCQVQVLKFLGTLAQKEALLFDIMNCQVHPDFLHLFQPSRPGNLLFELLVFVERLCEGRLTPQYQSVSWQYNESSLHEVLFGDDSRLADRLLSLIIHPEEEVQIQAFVSGILQLPPYTFWLPSQYRPKYRIVPLNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKK2</accession>
    <name>A0A670JKK2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Erbin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Densin-180-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Erbb2-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Protein LAP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ERBIN</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cell junction</location>
            <location evidence="11">Hemidesmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LAP (LRR and PDZ) protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028604667.1">
        <property type="nucleotide sequence ID" value="XM_028748834.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000026426.1">
        <property type="protein sequence ID" value="ENSPMRP00000024906.1"/>
        <property type="gene ID" value="ENSPMRG00000016094.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606495"/>
    <dbReference type="KEGG" id="pmua:114606495"/>
    <dbReference type="CTD" id="55914"/>
    <dbReference type="GeneTree" id="ENSGT00940000159526"/>
    <dbReference type="OMA" id="PIANHED"/>
    <dbReference type="OrthoDB" id="2187496at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071638">
        <property type="term" value="P:negative regulation of monocyte chemotactic protein-1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070433">
        <property type="term" value="P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032495">
        <property type="term" value="P:response to muramyl dipeptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06749">
        <property type="entry name" value="PDZ_densin_erbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000036">
        <property type="entry name" value="Erbin isoform 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000013">
        <property type="entry name" value="Erbin isoform 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000020">
        <property type="entry name" value="Erbin isoform 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000022">
        <property type="entry name" value="Erbin isoform 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
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    <sequence length="1458" mass="163003" checksum="77485848EF4894F5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            </authorList>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLM8</accession>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
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                <person name="Salvi D."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the NOSIP family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPMRP00000024424.1"/>
        <property type="gene ID" value="ENSPMRG00000015774.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:molecular sequestering activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045428">
        <property type="term" value="P:regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="RING-Ubox1_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16662">
        <property type="entry name" value="RING-Ubox2_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000251">
        <property type="entry name" value="Nitric oxide synthase-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001144">
        <property type="entry name" value="Nitric oxide synthase-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="NOSIP"/>
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        <property type="entry name" value="Znf-NOSIP"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
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    </dbReference>
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        <property type="entry name" value="ENOS_interacting"/>
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    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Nitric oxide synthase-interacting protein zinc-finger" evidence="14">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="273" mass="30647" checksum="4B0518FA0D600620" modified="2020-06-17" version="1">MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNVRLSKDAVKDFDCCCLSLQPCKDPVVTPDGYLYEKEAILEYILHQKKEIARQMKAYEKQKNEKKTELAELSKAAKESKVKNFLDKEMSIVSKPLNPFDRKAGDAQPGPSNEEKAKQLPSFWIPSLTPEAKTKVIPKPDKCVYCPMSMKPLKLKDLIPVHFTPVDASVDRVGLINRQDRYVCAVTRDMLGNSVPCAVLRPSGSVVTLECVERLIKKDMVDPVNGEKLTDKDIIVLQRVRMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JP03</accession>
    <name>A0A670JP03_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPEG neighbor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SPEGNB</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028596993.1">
        <property type="nucleotide sequence ID" value="XM_028741160.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028597003.1">
        <property type="nucleotide sequence ID" value="XM_028741170.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028597012.1">
        <property type="nucleotide sequence ID" value="XM_028741179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JP03"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026252.1">
        <property type="protein sequence ID" value="ENSPMRP00000024737.1"/>
        <property type="gene ID" value="ENSPMRG00000015992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602670"/>
    <dbReference type="KEGG" id="pmua:114602670"/>
    <dbReference type="CTD" id="100996693"/>
    <dbReference type="GeneTree" id="ENSGT00940000163812"/>
    <dbReference type="OMA" id="IEEDNRV"/>
    <dbReference type="OrthoDB" id="2152335at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055013">
        <property type="term" value="P:cardiac muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001489">
        <property type="entry name" value="SPEG neighbor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="149"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="240" mass="26064" checksum="9E25DF17DA88F2E7" modified="2020-06-17" version="1">MSKAAPKKPAAGAAAPPPAGFSLDINDPQVQNAAIRIQASYRGHRSRKEMKEKGPPRVLKNLTDVMLIEGSAAKLECRISAFPDPFIRWSKDGAELKDGPKYRYVFEDPDIVALVVRDAGLPDLGKYTISVKNPFGECFDSARLLVEVPAKIQKGPDSTKAKKGSTVNLTAHISGEPAPDVGWAKDGEDIEEDDRIYYNIGSDSTTLTIKKVSPADAGKYEVFVENSLGMDQSFARLDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRK2</accession>
    <name>A0A670JRK2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Insulin receptor substrate 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">IRS1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028586942.1">
        <property type="nucleotide sequence ID" value="XM_028731109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JRK2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027192.1">
        <property type="protein sequence ID" value="ENSPMRP00000025617.1"/>
        <property type="gene ID" value="ENSPMRG00000016596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597807"/>
    <dbReference type="KEGG" id="pmua:114597807"/>
    <dbReference type="CTD" id="3667"/>
    <dbReference type="GeneTree" id="ENSGT00940000161579"/>
    <dbReference type="OMA" id="MTMQMGC"/>
    <dbReference type="OrthoDB" id="946068at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005158">
        <property type="term" value="F:insulin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005159">
        <property type="term" value="F:insulin-like growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048009">
        <property type="term" value="P:insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046676">
        <property type="term" value="P:negative regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046326">
        <property type="term" value="P:positive regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032000">
        <property type="term" value="P:positive regulation of fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045725">
        <property type="term" value="P:positive regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046628">
        <property type="term" value="P:positive regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01257">
        <property type="entry name" value="PH_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01204">
        <property type="entry name" value="PTB_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000029">
        <property type="entry name" value="Insulin receptor substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000129">
        <property type="entry name" value="Insulin receptor substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039011">
        <property type="entry name" value="IRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614:SF11">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00628">
        <property type="entry name" value="INSULINRSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="IRS-type PTB" evidence="6">
        <location>
            <begin position="166"/>
            <end position="270"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="972"/>
            <end position="1205"/>
        </location>
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        <location>
            <begin position="138"/>
            <end position="165"/>
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        <location>
            <begin position="1466"/>
            <end position="1493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1631" mass="186407" checksum="D91FF290F8144AF7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWD8</accession>
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        <recommendedName>
            <fullName evidence="5">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Caspase recruitment domain family, member 11"/>
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    </dbReference>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="582" mass="66410" checksum="92F6D47222664FC0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JYP1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029558.1">
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        <property type="gene ID" value="ENSPMRG00000017993.1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
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    </dbReference>
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        <property type="entry name" value="Tim10-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="84" mass="9521" checksum="1B85330E8405EE6A" modified="2020-06-17" version="1">MAERMEADVSELQRLVAPKEQQARLTTHVHNFMEVCWEKRVDKPGSKLDSRTETCLTNCINCFIDTTLSITTNCLAQIVQKGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYZ0</accession>
    <name>A0A670JYZ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JYZ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030838.1">
        <property type="protein sequence ID" value="ENSPMRP00000029070.1"/>
        <property type="gene ID" value="ENSPMRG00000018794.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154179"/>
    <dbReference type="OMA" id="NSCKFIT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025488970" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="14028" checksum="996B6DE4706C1982" modified="2020-06-17" version="1">MVWALSFLALLSYFSGVISQPSVTQPASESVSPGQTAKLSCTASGGTTMYWYQQKPGQVPRYLHCDGCSSRGPGIPNRFTASRSGTAGHLSIANLESEDEAVYYCAVWLSSSFHCSKFLWGTVTKTSFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZC3</accession>
    <name>A0A670JZC3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="4">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DTD1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028594171.1">
        <property type="nucleotide sequence ID" value="XM_028738338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JZC3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032489.1">
        <property type="protein sequence ID" value="ENSPMRP00000030633.1"/>
        <property type="gene ID" value="ENSPMRG00000019836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601186"/>
    <dbReference type="KEGG" id="pmua:114601186"/>
    <dbReference type="CTD" id="92675"/>
    <dbReference type="GeneTree" id="ENSGT00940000153431"/>
    <dbReference type="OMA" id="VFGADMK"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="207" mass="23361" checksum="18A269517A9E0354" modified="2020-06-17" version="1">MKAIIQRVARASVTVGGEQISSIGQGICVLLGISVEDTQKEIEHMVRKILNLRVFEDESGKHWSKSVMDKQYEVLCVSQFTLQCILKGNKPDYHMAMPTDQAETFYNSFVEHLRKSYKPELIKDGKFGEYMQVHIQNDGPVTIELESPAPPIDPKQLAKLEKQQQRKEKTRMKAPSESSRERNVPRSKNDPSASSGAEGDVSSEREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZQ7</accession>
    <name>A0A670JZQ7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgin subfamily A member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GOLGA7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JZQ7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032636.1">
        <property type="protein sequence ID" value="ENSPMRP00000030773.1"/>
        <property type="gene ID" value="ENSPMRG00000019937.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000134"/>
    <dbReference type="OMA" id="CEMRPQQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF1">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="9">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="162" mass="18565" checksum="8DCA08F19D440845" modified="2020-06-17" version="1">MRSPLTSPVYVLFPPTSRLASSSCEMRPQQPPVASKVFVQRDYSSGTKCQFQTKFPPELENRVDRQQFEETVRTLNNLYAEAEKLGSQSYLEGCLACLTAYTIFLCMETHYEKVLKKIAKYIQEQNEKIYAPQGILLTDPIERGLRVIEITIYEDRGVNSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZV0</accession>
    <name>A0A670JZV0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Troponin T, slow skeletal muscle</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Slow skeletal muscle troponin T</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TNNT1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with TPM3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the troponin T family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JZV0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031923.1">
        <property type="protein sequence ID" value="ENSPMRP00000030106.1"/>
        <property type="gene ID" value="ENSPMRG00000019466.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of muscle contraction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031444">
        <property type="term" value="P:slow-twitch skeletal muscle fiber contraction"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF6">
        <property type="entry name" value="TROPONIN T, SLOW SKELETAL MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="321" mass="37755" checksum="994AB6BA93E278BD" modified="2020-06-17" version="1">MSDEEAEYEEEQQEVADEPEQAAEQEEERPRPRPVVPQLAPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVGLMSRIEHRRAERAEQQRVRTEKERERQNKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKIRILSERRKPLNVENLSEQQLRDTAKELHDWIHQLESEKFDLMEKYKCQKYEVRREKKKYTFGYRTFPGAKMILTSISLSLCCVFSLLSRSMFFTTASATPRNSRKVPEKPDLVAAGSKEEDTHPPTIHAEIWEPLLIAASHCFPCPVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0R4</accession>
    <name>A0A670K0R4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">START domain-containing protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PCTP-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">StAR-related lipid transfer protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114589146</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028571105.1">
        <property type="nucleotide sequence ID" value="XM_028715272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K0R4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032999.1">
        <property type="protein sequence ID" value="ENSPMRP00000031108.1"/>
        <property type="gene ID" value="ENSPMRG00000020166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589146"/>
    <dbReference type="KEGG" id="pmua:114589146"/>
    <dbReference type="GeneTree" id="ENSGT00510000047611"/>
    <dbReference type="OMA" id="NSCIFIY"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046581">
        <property type="term" value="C:intercellular canaliculus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08871">
        <property type="entry name" value="START_STARD10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000008">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
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    </dbReference>
    <dbReference type="InterPro" id="IPR041951">
        <property type="entry name" value="STARD10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF7">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
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    </dbReference>
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        <property type="entry name" value="Bet v1-like"/>
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    </dbReference>
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        <property type="entry name" value="START"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="265" mass="30452" checksum="FDB24791DDE5390E" modified="2020-06-17" version="1">MEPVSLPDDAAFRDFVAECESQDGWLSWYDRSGVSVWEQVVPYADLAVYRLKGMIDMAGVSAETAYDVLHDTEYRSMWDINLVETHQIARLTDNADISYYEWKCPKPLRNRDVVTLRSWKVLDKDYIIMNFSVKHPNYPPRKDTVRAASRLAGYLVQPTGRDSCKLTYLALLDPKGFLPKWIVNKAVQFLGPQVMRKLHKACMEYPAWKQEHNMDVKPWLHPEQSQLPTMLVSELAIQHAASLEHFDESSVKEVKDQQGEASGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0Z2</accession>
    <name>A0A670K0Z2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A670K0Z2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033070.1">
        <property type="protein sequence ID" value="ENSPMRP00000031178.1"/>
        <property type="gene ID" value="ENSPMRG00000020185.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166769"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF23">
        <property type="entry name" value="LOC100144966 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="375" mass="42400" checksum="5D1F6FC28DA2FFF8" modified="2020-06-17" version="1">RDQQPHLPGDTGYLTIWDKGYYPVRKGEVFNGRYHVAQSLGCGYFSTVWLCQDLGKKRCVAVKVPKGGEDFAEAALDEVMLLRCVNSKRRKDQGSDRVIHFLDDFKMIGDNGFHILWLVDNLLGPSLQSLLSSQGVQGLPLPFVKKATQQVLQGLHFLHKECRIIHADIKPENILLCSAEGSLQALLHQVAFQEHGEDVAAVLDCCNLMKLGVKIADLGSACWTYKPFSKKIQTQPYRALEVLLGLDYGTPADIWSTACLVFELATGDRLFDPQAGQYFSRDDDHVVRIIELLGRIPPKVALFWKRATTFFNRQGALLRMSWLSPYDLYHILTDKYSWPKHQASPLASFLLPMLEYAPERRAAADKCLQHPWLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2Q3</accession>
    <name>A0A670K2Q3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Centrosomal protein of 104 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CEP104</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for ciliogenesis and for structural integrity at the ciliary tip.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with CCP110 and CEP97. Interacts with ARMC9, TOGARAM1, CCDC66 and CSPP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028596265.1">
        <property type="nucleotide sequence ID" value="XM_028740432.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028596267.1">
        <property type="nucleotide sequence ID" value="XM_028740434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K2Q3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033717.1">
        <property type="protein sequence ID" value="ENSPMRP00000031788.1"/>
        <property type="gene ID" value="ENSPMRG00000020589.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602334"/>
    <dbReference type="KEGG" id="pmua:114602334"/>
    <dbReference type="CTD" id="9731"/>
    <dbReference type="GeneTree" id="ENSGT00390000013405"/>
    <dbReference type="OMA" id="VQGNDYN"/>
    <dbReference type="OrthoDB" id="66599at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000200">
        <property type="entry name" value="Centrosomal protein of 104 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048738">
        <property type="entry name" value="CEP104_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21039">
        <property type="entry name" value="CEP104_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="14">
        <location>
            <begin position="429"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="893"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="682"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="947" mass="107316" checksum="DD1C9A493F232BC0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K420</accession>
    <name>A0A670K420_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">SOSS complex subunit C</fullName>
            <shortName evidence="6">SOSS-C</shortName>
            <shortName evidence="6">SSB-interacting protein 1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 6">Sensor of single-strand DNA complex subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5 6">Sensor of ssDNA subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4 6">Single-stranded DNA-binding protein-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114587408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SOSS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SOSS-C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028567438.1">
        <property type="nucleotide sequence ID" value="XM_028711605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K420"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034242.1">
        <property type="protein sequence ID" value="ENSPMRP00000032288.1"/>
        <property type="gene ID" value="ENSPMRG00000020930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587408"/>
    <dbReference type="GeneTree" id="ENSGT00390000006366"/>
    <dbReference type="OMA" id="HAEQHHI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031821">
        <property type="entry name" value="SOSSC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31526">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31526:SF2">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15925">
        <property type="entry name" value="SOSSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="104" mass="11482" checksum="0EA4472FECD81621" modified="2020-06-17" version="1">MTSNPPGQGFQNKNRVAILAELDKEKRKLLMQNQSSTNHPGASISLARSSLNKDFRDHAELQHIAAQQKAALQHAHAHSSGYFITQDSAFGNLILPVLPRLDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4S3</accession>
    <name>A0A670K4S3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MPHOSPH10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K4S3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031736.1">
        <property type="protein sequence ID" value="ENSPMRP00000029927.1"/>
        <property type="gene ID" value="ENSPMRG00000019350.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011359"/>
    <dbReference type="OMA" id="HFAEDFG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="587" mass="66583" checksum="93C4CD5D589A530A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4Y9</accession>
    <name>A0A670K4Y9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.13</ecNumber>
            <ecNumber evidence="4">3.6.1.16</ecNumber>
            <ecNumber evidence="6">3.6.1.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ADPRibase-Mn</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">CDP-choline phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ADPRM</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ADP-D-ribose + H2O = D-ribose 5-phosphate + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:10412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ADP-D-ribose + H2O = D-ribose 5-phosphate + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:10412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>CDP-choline + H2O = phosphocholine + CMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.6.1.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:21692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58311"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="3.6.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADPRibase-Mn family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.13" evidence="5"/>
    <dbReference type="EC" id="3.6.1.16" evidence="4"/>
    <dbReference type="EC" id="3.6.1.53" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028572919.1">
        <property type="nucleotide sequence ID" value="XM_028717086.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028572920.1">
        <property type="nucleotide sequence ID" value="XM_028717087.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028572921.1">
        <property type="nucleotide sequence ID" value="XM_028717088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K4Y9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031771.1">
        <property type="protein sequence ID" value="ENSPMRP00000029962.1"/>
        <property type="gene ID" value="ENSPMRG00000019366.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114590700"/>
    <dbReference type="KEGG" id="pmua:114590700"/>
    <dbReference type="CTD" id="56985"/>
    <dbReference type="GeneTree" id="ENSGT00390000014667"/>
    <dbReference type="OMA" id="GHNHAGN"/>
    <dbReference type="OrthoDB" id="9675250at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047734">
        <property type="term" value="F:CDP-glycerol diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07396">
        <property type="entry name" value="MPP_Nbla03831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041869">
        <property type="entry name" value="MPP_ADPRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16509">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16509:SF1">
        <property type="entry name" value="MANGANESE-DEPENDENT ADP-RIBOSE_CDP-ALCOHOL DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="350" mass="40300" checksum="A3CB34A0624306C5" modified="2020-06-17" version="1">MDDDNNCSCTQGATTSEALFSFGVIADIQYADREDGYDFCGLNRRYYKHSLCHLQSAIEDWNRTDVQFVLQFGDIIDGCNAELKMSETALGRVLEEFKKLKAPVHHIWGNHEFYNFSRDYLVDSALNTKYLQEQTFLSNSYRDQSSTGDDASEFYYAYQFCPMSKFRFVILDAYDISILGRDTSTKKYQDSLKLLREKNQNENLNSPSGLVERQFVQFNGGFSQEQLDWLDEVLTYADKNQERVVIMGHIPIHPNSTSDVALAWNYKDALSVIHSHHSVVCFLAGHLHFGGYCLDSYGVHHVTLDGIIETPPESHAFGTIHVYHDRMVLEGRGRILDRVMHYKGYQTFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K523</accession>
    <name>A0A670K523_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PHKB</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Lipid-anchor</topology>
            <orientation evidence="1 7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K523"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031803.1">
        <property type="protein sequence ID" value="ENSPMRP00000029992.1"/>
        <property type="gene ID" value="ENSPMRG00000019388.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183118"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="9">
        <location>
            <begin position="154"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1198" mass="135738" checksum="F20434E4882D0D66" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K549</accession>
    <name>A0A670K549_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-binding cassette sub-family G member 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sterolin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ABCG8</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K549"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032642.1">
        <property type="protein sequence ID" value="ENSPMRP00000030779.1"/>
        <property type="gene ID" value="ENSPMRG00000019930.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159739"/>
    <dbReference type="OMA" id="WLAWEDY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045796">
        <property type="term" value="P:negative regulation of intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010949">
        <property type="term" value="P:negative regulation of intestinal phytosterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03234">
        <property type="entry name" value="ABCG_White"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000831">
        <property type="entry name" value="ATP-binding cassette sub-family G member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF71">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="34"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="654" mass="74747" checksum="30F8C8976B7137C7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5X7</accession>
    <name>A0A670K5X7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="50">Autotaxin</fullName>
            <ecNumber evidence="49">3.1.4.39</ecNumber>
            <ecNumber evidence="6">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="51">Ectonucleotide pyrophosphatase/phosphodiesterase family member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="52">Extracellular lysophospholipase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="56" type="primary">ENPP2</name>
    </gene>
    <organism evidence="56 57">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="56 57" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="56" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="56" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41412"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78226"/>
            <dbReference type="ChEBI" id="CHEBI:78227"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41413"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41416"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78228"/>
            <dbReference type="ChEBI" id="CHEBI:78229"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41417"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41139"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74344"/>
            <dbReference type="ChEBI" id="CHEBI:74938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41135"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28733"/>
            <dbReference type="ChEBI" id="CHEBI:74547"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:41136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + L-serine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38931"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74617"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:38932"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38915"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:38916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38927"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74971"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:38928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41684"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64396"/>
            <dbReference type="ChEBI" id="CHEBI:78402"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41143"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
            <dbReference type="ChEBI" id="CHEBI:77580"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-decanoyl-sn-glycero-3-phosphocholine + H2O = 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41131"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:77724"/>
            <dbReference type="ChEBI" id="CHEBI:77726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38991"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72682"/>
            <dbReference type="ChEBI" id="CHEBI:74966"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:38992"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38975"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:38976"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41400"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78215"/>
            <dbReference type="ChEBI" id="CHEBI:78223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38979"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:74565"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:38980"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38983"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
            <dbReference type="ChEBI" id="CHEBI:72683"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:38984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ADP + H2O = AMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:14446"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41588"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:77283"/>
            <dbReference type="ChEBI" id="CHEBI:77287"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39927"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:58014"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:39928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:58014"/>
            <dbReference type="ChEBI" id="CHEBI:76168"/>
            <dbReference type="EC" id="3.1.4.39"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phosphate + L-serine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:64379"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:39000"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38995"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:38996"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39003"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:64381"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:39004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>a 2-acyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycerol 3-phosphate + L-serine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41716"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:64982"/>
            <dbReference type="ChEBI" id="CHEBI:65214"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41712"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="ChEBI" id="CHEBI:64982"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41713"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>sphing-4-enine-phosphocholine + H2O = sphing-4-enine 1-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38919"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58906"/>
            <dbReference type="ChEBI" id="CHEBI:60119"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="48">
            <dbReference type="Rhea" id="RHEA:38920"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.39" evidence="49"/>
    <dbReference type="EC" id="3.1.4.4" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028592071.1">
        <property type="nucleotide sequence ID" value="XM_028736238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K5X7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032074.1">
        <property type="protein sequence ID" value="ENSPMRP00000030247.1"/>
        <property type="gene ID" value="ENSPMRG00000019517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600292"/>
    <dbReference type="CTD" id="5168"/>
    <dbReference type="GeneTree" id="ENSGT00940000155778"/>
    <dbReference type="OMA" id="NICLGYT"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047391">
        <property type="term" value="F:alkylglycerophosphoethanolamine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034638">
        <property type="term" value="P:phosphatidylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000394">
        <property type="term" value="P:positive regulation of lamellipodium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000144">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase 2, short form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000001">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000006">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.20:FF:000001">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.20:FF:000002">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020436">
        <property type="entry name" value="SMB_chordata"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF21">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00022">
        <property type="entry name" value="SOMATOMEDINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00201">
        <property type="entry name" value="SO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="11" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="22" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="54" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1201">Platelet aggregation inhibiting toxin</keyword>
    <keyword evidence="57" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0800">Toxin</keyword>
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    <keyword evidence="54" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="12"/>
            <end position="30"/>
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            <begin position="320"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00050409"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="38">
        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00066852"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00071948"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00075924"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00081337"/>
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    <evidence type="ECO:0000256" key="53">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="54">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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        <source>
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    <sequence length="911" mass="104489" checksum="ED7EB1424705D3DA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6S3</accession>
    <name>A0A670K6S3_PODMU</name>
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        <recommendedName>
            <fullName evidence="11">Mortality factor 4-like protein 1</fullName>
        </recommendedName>
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        <name evidence="15" type="primary">MORF4L1</name>
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    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="term" value="C:Sin3-type complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
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    </dbReference>
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        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
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        <property type="entry name" value="CHROMO"/>
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    <dbReference type="SUPFAM" id="SSF54160">
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        <property type="entry name" value="MRG"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
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        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="103"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032516.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="390" mass="45062" checksum="F577C29D01A1EA29" modified="2020-06-17" version="1">MNVNGSLHLHFSAMMILFSVCVVRVRLGLLFLLNGNFLTGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKNWDEWVPESRVLKYVDTNLQKQKELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGIGEGSSTNENPQPPRKKRARVDPTVESEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSSTLFSASDYEVAPPEYHRKAVWNCCRPTSQGRFSFRRISFKGRASRSVSLDRFWCWNVVLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K714</accession>
    <name>A0A670K714_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ring finger protein 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RNF38</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K714"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034543.1">
        <property type="protein sequence ID" value="ENSPMRP00000032576.1"/>
        <property type="gene ID" value="ENSPMRG00000021094.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156228"/>
    <dbReference type="OMA" id="EYRTEEM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000024">
        <property type="entry name" value="RING finger protein 44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="772"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="815" mass="88597" checksum="D7205E5948E2EFD0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7C1</accession>
    <name>A0A670K7C1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hexosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">B3GALT5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = a globoside GalGb4Cer (d18:1(4E)) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41996"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18259"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:62571"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:41997"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus membrane</location>
            <topology evidence="1 14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A670K7C1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034644.1">
        <property type="protein sequence ID" value="ENSPMRP00000032671.1"/>
        <property type="gene ID" value="ENSPMRG00000021171.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160964"/>
    <dbReference type="OMA" id="HSQQTFF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008499">
        <property type="term" value="F:N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF265">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="360" mass="42239" checksum="4549F336E37A41ED" modified="2020-06-17" version="1">MAIELHLEFTNTFLVLDFISCCLGAKTFFLLRKFKHSLKMASKRLARMLVFTMALVCFLCLYAKLCTFEICIFCETKHEFFPFKRDGRFLKRPHMNCRRNPPFLVILVTSSHKQSKARMAIRKTWGRERKIDNKRIVTYFLLGSTLTDVDQRAIDDENKKHRDIIQKDFLDSYYNLTLKTIMGLEWIHKFCPQTSFVMKTDSDMFVNTYYLTELLLKKNKKVSFFTGFLKENEHPIRKLISKWYVSEEEYSGNLYPPFCSGTGYVLSADVASSVYKIAKEVPYFKLEDVYVGMCLAKLDIKLEELHSEQTFFPDGLVFSACRFRKIVTSHFVRPHENLIYWDALERSLDENCHPGTYPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8P0</accession>
    <name>A0A670K8P0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcyphosine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CAPS</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K8P0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035987.1">
        <property type="protein sequence ID" value="ENSPMRP00000033928.1"/>
        <property type="gene ID" value="ENSPMRG00000022005.1"/>
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        <property type="component" value="Chromosome 18"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0106">Calcium</keyword>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
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        <location>
            <begin position="55"/>
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        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="91"/>
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        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="187" mass="21191" checksum="81A88E9F7397D146" modified="2020-06-17" version="1">METGAIVKLRAKCLERGASGIKGLARFFRVMDDDRSKTLDLEEFVQGLRDAGVPLERSEAQEIFAFCDKNRSGTLDFDEFLEALRPPMSEARKEVIRQAFQKLDRTGDGLVTVEDLRGVYNGRCHPKFKSGEWTEEQVFRSFLDSFDSPDDKDGKVTAEEFLNYYSAVSASIDSDDYFVGMVKAAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9V8</accession>
    <name>A0A670K9V8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab9 effector protein with kelch motifs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RABEPK</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Rab9 effector required for endosome to trans-Golgi network (TGN) transport.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028571768.1">
        <property type="nucleotide sequence ID" value="XM_028715935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K9V8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035148.1">
        <property type="protein sequence ID" value="ENSPMRP00000033130.1"/>
        <property type="gene ID" value="ENSPMRG00000021483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589528"/>
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    <dbReference type="GeneTree" id="ENSGT00940000158763"/>
    <dbReference type="OMA" id="CTPGSIW"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052124">
        <property type="entry name" value="Rab9_kelch_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647:SF1">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Galactose oxidase, central domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="365" mass="39349" checksum="45A3089871EE9441" modified="2020-06-17" version="1">MGPEPGSRTALLELKPGGNPEEGNWYALLLPGDSPCARVGQNSLYLPPAEPGSRKGKVILVGGADPSGSFADSYVMDLDAHCWTAPAWRGLLPRYEHATFIPTSWPTSLWVFGGASETGNRNCVQVLDLQAGTWMSPKVTGTPPSPRTYHTSSAVIGDRLYVFGGGDKGVDPVKDQQLHIFDSATLTWLQPEVQGDPPAPRHGHAVVAVENRLYIHGGLAGDTFFDDLFCFDTTEMKWETLSATGSVPAGRAAHSAVVFQGHLYIFGGMDPTGALDTMYKYHIEKGHWTKLEFKTPVPSARLDQSMCVVPWKVSSSEDSNRKEAAGGSNGDNLSQGCPDEHLCLVFGGMDIKGEIYKDSAVTLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9W6</accession>
    <name>A0A670K9W6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Doublesex and mab-3 related transcription factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DMRT3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028568318.1">
        <property type="nucleotide sequence ID" value="XM_028712485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K9W6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035158.1">
        <property type="protein sequence ID" value="ENSPMRP00000033140.1"/>
        <property type="gene ID" value="ENSPMRG00000021491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587769"/>
    <dbReference type="KEGG" id="pmua:114587769"/>
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    <dbReference type="GeneTree" id="ENSGT00940000160420"/>
    <dbReference type="OMA" id="CPIVTKQ"/>
    <dbReference type="OrthoDB" id="5842031at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046661">
        <property type="term" value="P:male sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042487">
        <property type="term" value="P:regulation of odontogenesis of dentin-containing tooth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021521">
        <property type="term" value="P:ventral spinal cord interneuron specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14419">
        <property type="entry name" value="CUE_DMA_DMRTA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005173">
        <property type="entry name" value="DMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF120">
        <property type="entry name" value="DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03474">
        <property type="entry name" value="DMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="10">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="8">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="487" mass="52107" checksum="66C5CEC4C814582C" modified="2020-06-17" version="1">MNGYGSPYLYMGGPVAPPARAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLIPDALRALPAAAAAAPGSAGATTTGHPGVGAAAGAAAAAVAPSEGPPGTPHRPPMELAAAALRWASEQPAAVQPPQLPKADMTEDRLGDASGVDSAETYSDKDADQRSTPDLTKAKSGFAPESPEIVSVDEGGYAIQKNSGSTDSRPESPKYQPEPNHLLIEGPSGTVSLPFGLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSIAGGDRTSAESEGLVLPSNGHLFEHTLGSYPISSSKWSVGSAFRVPDTLRFSADASNVVPNPLAVPLQHPFPQPPRYPLMLRNTLARNQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFSTNTTSVFRSSPVLPTRPSEDPRISIPDDGCPIVSKQPIYTEDDYDERSDSSDSRILNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KD21</accession>
    <name>A0A670KD21_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KD21"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037460.1">
        <property type="protein sequence ID" value="ENSPMRP00000035333.1"/>
        <property type="gene ID" value="ENSPMRG00000022860.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00970000197109"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10550" checksum="ECE3F011784C7907" modified="2020-06-17" version="1">MAAQKLVTAVITQGPKLVSAAITYSKPGLATFWYWLPQLLLKLLRLLMAWIAEEHAVKQLAVKEALRNGLVATEVLMWFYSSEIIGKCGLVGYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDQ3</accession>
    <name>A0A670KDQ3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670KDQ3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036609.1">
        <property type="protein sequence ID" value="ENSPMRP00000034510.1"/>
        <property type="gene ID" value="ENSPMRG00000022397.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="CDEIFTI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="325" mass="37603" checksum="96C70B2148DC4C5D" modified="2020-06-17" version="1">MEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTTDWFKIGKGVRQGCILSPCLFNLYAEFIMRKAGLDESLAGIKIARRNINNFRYADDTTLMAKSEEELKNLLLRVKEESAKYGLKLNIKKTKIMATGPITFWQIEGEEMEAVRDFTFLGSMITADGDSSHEIKRRLLLGRKAMTNLDSILKSRDITLPTKVRIVKAMVFTVVMYGNESWTIKKADRQRIDAFEFWCWRRLLRVPGTARRSNLSILKEISPECSLEGQILKLRLQDFGHLMRREDSLEKTLMLGKMEGTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEE2</accession>
    <name>A0A670KEE2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="18">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">PRKG2</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with GRIA1/GLUR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Apical cell membrane</location>
            <topology evidence="16">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 18">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="18"/>
    <dbReference type="RefSeq" id="XP_028600271.1">
        <property type="nucleotide sequence ID" value="XM_028744438.1"/>
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    <sequence length="781" mass="89242" checksum="FF408E4B3708706B" modified="2020-06-17" version="1"> </sequence>
</entry>
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</entry>
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    <accession>A0A670KG60</accession>
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        <name evidence="19" type="primary">CACNA1I</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="19" key="2">
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                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
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            <taxon>Lacertibaenia</taxon>
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        <location>
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            <begin position="21"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="407" mass="44760" checksum="384524B2A810BB91" modified="2020-06-17" version="1">MRCSWMGLALLLPSLGLCAAIQWLSLAANGTQVAWDNPQDCRLLASDALARLCRRHLEAMPSLVEAARQTKAVCQQTFANSRWNCSSVEGTPHLAPDLQRGTRESAFVYALASSAASHSIARACASGQVPFCFCGSSPSEAPHPSFQWGGCGDNLPFGLQLGSAFVDGPMKFSKAGRQISRVLNLHNNAVGRQVSRVIPALQGVGLDAPRVPDFIIWYWRIQVRELWVQEVQFSPLGCLTVLLLSFRLLLSQVLSDSLETMCKCHGVSGSCTVKTCWKGLRDLATIGSELKSKYLEATQVMPWLVGSRRQLAPRGGRLRPLKADELAYLVHSPTYCLKNPKLGSLGTQDRPCNKTSAGSGGCRLLCCGRGYNTYAERVEEKCRCRYHWCCYVTCKKCQRVVEKHVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJQ5</accession>
    <name>A0A670KJQ5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KJQ5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038719.1">
        <property type="protein sequence ID" value="ENSPMRP00000036550.1"/>
        <property type="gene ID" value="ENSPMRG00000023574.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154136"/>
    <dbReference type="OMA" id="WRWNEEN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="354" mass="41187" checksum="CAD8EAACD740454E" modified="2020-06-17" version="1">MSSWDFMVSYQFSDCHLWVGCCVCALTLERLWQERKVKESFPLTPKWRWNEENRSNYATTQWICNWLTDRTQRVLINGSSSSWRRVTSGVPQGSVLGPVLFNIFINDLDDGLKGILIKCADDTKLGGVANTPEDRITLQNDLDRLENWAKTNKMNFNREKCKVLHLGIKNERHKYKMGDTWLESSTCEKDLGVLIDHKLDMSQQCDAAAKKANAILGLINRSIASRSREVIVPLYSALVRPHLEYCVQFWAPQFKKDSDKLERVQRRATKMVKGLETMPYEERLRELGMFSLEKRRLRGDMIAMFKYIKGCHIEEGERLFSAAPEKRTRSNGSKLQERRFHLNIRKNFLTVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLD2</accession>
    <name>A0A670KLD2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ephrin-B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">EFNB1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KLD2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037649.1">
        <property type="protein sequence ID" value="ENSPMRP00000035517.1"/>
        <property type="gene ID" value="ENSPMRG00000022965.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160128"/>
    <dbReference type="OMA" id="QAEFCST"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000785">
        <property type="term" value="P:regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10426">
        <property type="entry name" value="Ephrin-B_Ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000027">
        <property type="entry name" value="ephrin-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034255">
        <property type="entry name" value="Ephrin-B_Ecto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019765">
        <property type="entry name" value="Ephrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF17">
        <property type="entry name" value="EPHRIN-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01299">
        <property type="entry name" value="EPHRIN_RBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025416635" description="Ephrin-B1" evidence="17">
        <location>
            <begin position="36"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Ephrin RBD" evidence="18">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="177"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="95"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="359" mass="39770" checksum="F0DDF65B25BEC3D9" modified="2020-06-17" version="1">MGRPEGTHDGRRLLCRRLLLGLLLALCRLAPPLLAKSLEPVAWSAANPKFVSGKGLIIYPEIGDKLDIICPKAESSRPYEYYKLYLVKRGQADACSTIMDPNVLVTCNRPDQEIRFTIKFQEFSPNYMGLEFKRHQDYFITSTSNGSLEGLENREGGVCQTRSMKIIMKVGQDPNAVMPEQLTTSRPSKDSDNTVKIATQSPRNRLPPVEDPGKPDHVNQDGQDGQSPGNGFFSSKVAVFAAIGAGCVIFILIIIFLVVLLIKLRKRHRKHTQQRAQALSLSTLASPKCGGSGGSEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKVDSAFKLTRPGGLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KM37</accession>
    <name>A0A670KM37_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLDN1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587663.1">
        <property type="nucleotide sequence ID" value="XM_028731830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KM37"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037977.1">
        <property type="protein sequence ID" value="ENSPMRP00000035832.1"/>
        <property type="gene ID" value="ENSPMRG00000023150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598126"/>
    <dbReference type="KEGG" id="pmua:114598126"/>
    <dbReference type="CTD" id="9076"/>
    <dbReference type="GeneTree" id="ENSGT00940000155387"/>
    <dbReference type="OMA" id="MPQWKIS"/>
    <dbReference type="OrthoDB" id="10025519at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001618">
        <property type="term" value="F:virus receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016338">
        <property type="term" value="P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034331">
        <property type="term" value="P:cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061436">
        <property type="term" value="P:establishment of skin barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060054">
        <property type="term" value="P:positive regulation of epithelial cell proliferation involved in wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090303">
        <property type="term" value="P:positive regulation of wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003548">
        <property type="entry name" value="Claudin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01377">
        <property type="entry name" value="CLAUDIN1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="211" mass="22948" checksum="FB585E6B9570E3DE" modified="2020-06-17" version="1">MANSGLQMLGFILAFVGWVGLIISTAMPQWKINAYAGENIVTAQAIYQGLWMNCVTQSTGQMQCKAFDTLLSLPSILQATRALMVASILLGLIAFSISLIGMKCMKCMEDDQVQKMRMAIIGGIFFLVAGFAALVGTSWYGNEVARQFFDIYTPVNTRFEFGPALFIGWAAAALTILGGGFLCCSCPRRETTYPPSRPYPKCAPSSGKDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KP59</accession>
    <name>A0A670KP59_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase</fullName>
            <ecNumber evidence="18">2.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Alpha-2,8-sialyltransferase 8A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ganglioside GD3 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Sialyltransferase 8A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Sialyltransferase St8Sia I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">ST8SIA1</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>[alpha-N-acetylneuraminyl-(2-&gt;8)](n)-alpha-N-acetylneuraminyl-(2-&gt;8)-alpha-N-acetylneuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide + CMP-N-acetyl-beta-neuraminate = [alpha-N-acetylneuraminyl-(2-&gt;8)](n+1)-alpha-N-acetylneuraminyl-(2-&gt;8)-alpha-N-acetylneuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77371"/>
            <dbReference type="Rhea" id="RHEA-COMP:18881"/>
            <dbReference type="Rhea" id="RHEA-COMP:18935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:197322"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:77372"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41768"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78445"/>
            <dbReference type="ChEBI" id="CHEBI:78447"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41769"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>a ganglioside GD3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41764"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78436"/>
            <dbReference type="ChEBI" id="CHEBI:78438"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41765"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:79214"/>
            <dbReference type="ChEBI" id="CHEBI:79216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:77296"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
            <dbReference type="ChEBI" id="CHEBI:87787"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:47577"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41760"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60065"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78436"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41761"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41772"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78452"/>
            <dbReference type="ChEBI" id="CHEBI:78455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;8)-N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:140308"/>
            <dbReference type="ChEBI" id="CHEBI:140309"/>
            <dbReference type="EC" id="2.4.3.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.8" evidence="18"/>
    <dbReference type="RefSeq" id="XP_028601867.1">
        <property type="nucleotide sequence ID" value="XM_028746034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KP59"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039022.1">
        <property type="protein sequence ID" value="ENSPMRP00000036847.1"/>
        <property type="gene ID" value="ENSPMRG00000023738.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605143"/>
    <dbReference type="KEGG" id="pmua:114605143"/>
    <dbReference type="CTD" id="6489"/>
    <dbReference type="GeneTree" id="ENSGT01030000234535"/>
    <dbReference type="OMA" id="MAGLAWK"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050679">
        <property type="term" value="P:positive regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23989">
        <property type="entry name" value="GT29_ST8SIA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000014">
        <property type="entry name" value="Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF3">
        <property type="entry name" value="ALPHA-N-ACETYLNEURAMINIDE ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 32" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="31">
        <location>
            <begin position="138"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00042820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00043723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00043743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00043792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00043813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00043833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00044457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00044471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="349" mass="39858" checksum="138BA1AE8147139F" modified="2020-06-17" version="1">MSDWKAGKRHRRMAAGLLACKGPRTRLPVGASALGFFVLCWLYIFPVYRLPDEKEVVQGVLLQQGRAWRRNRSAVAGFRKLLKDCCDPGRFFAMTKENSPVGKNLWYDGEFLYSFTIDNETFSLFPKATPFQLPLKKCSVVGNGGILKNSGCGRQIDQADFVMRCNLPPLTSEYSKDVGSRTQLVTANPSIIKKRFQNLLWSRKAFVDSVKVYNQSYIYMPAFSMKAGTEPSLRVYYTLADVGARQKVIFANPNFLRDIGKFWKNKGIHGKRLSTGLFLVSAALGLCEEVTIYGFWPFSMDLHGKFISHHYYDNILPDSWFHAMPEEFLQLWFLHKSGVLRMQLEHCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HKG2</accession>
    <name>A0A670HKG2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sp9 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SP9</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605206.1">
        <property type="nucleotide sequence ID" value="XM_028749373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HKG2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000310.1">
        <property type="protein sequence ID" value="ENSPMRP00000000294.1"/>
        <property type="gene ID" value="ENSPMRG00000000219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606801"/>
    <dbReference type="KEGG" id="pmua:114606801"/>
    <dbReference type="CTD" id="100131390"/>
    <dbReference type="GeneTree" id="ENSGT00940000162304"/>
    <dbReference type="OMA" id="SASSWWD"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22549">
        <property type="entry name" value="SP9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000077">
        <property type="entry name" value="Sp8 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR SP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="402"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="453" mass="46981" checksum="8D28C5AEFA7C4C9F" modified="2020-06-17" version="1">MATSILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPESSAFAKGSFHPWKRSTSSCNLGSSLSGFTVATSRGSSGLASGSGTANSAFCLASTSPTSSAFSSDYSGLFSNAAAAAGVSPQEAGGQSAFISKVHSSAADSLYPRVGMAHPYESWYKSGFHSTLAAGEVANGAASSWWDVHTNPGSWLEVQNPAGGLQSPLHSGAPQASLHSQLGTYNPADFSSLTHSAFSSTGLGSTAASHLLSTSQHLLTQEGFKPVLPSYTDSSAAVAAASAMISGAAAAAAAGGGSARSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHNGGGGGKKGSDSDTDASNLETPRSESPDLILHEARGKDSTAGPNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HKV8</accession>
    <name>A0A670HKV8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein salvador homolog 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">45 kDa WW domain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SAV1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer. Stabilized through interaction with STK3/MST2 or STK4/MST1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presence of STK3/MST2. Interacts with WTIP and AJUBA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028576956.1">
        <property type="nucleotide sequence ID" value="XM_028721123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HKV8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000110.1">
        <property type="protein sequence ID" value="ENSPMRP00000000105.1"/>
        <property type="gene ID" value="ENSPMRG00000000068.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592822"/>
    <dbReference type="KEGG" id="pmua:114592822"/>
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    <dbReference type="GeneTree" id="ENSGT00940000156106"/>
    <dbReference type="OMA" id="AARYYYP"/>
    <dbReference type="OrthoDB" id="5339429at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:molecular adaptor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
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        <property type="term" value="F:transcription regulator activator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cardiac muscle cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:epithelial cell proliferation"/>
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        <property type="term" value="P:hippo signaling"/>
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        <property type="term" value="P:intestinal epithelial cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:keratinocyte apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:keratinocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:lung epithelial cell differentiation"/>
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    </dbReference>
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        <property type="term" value="P:negative regulation of cardiac muscle cell proliferation"/>
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        <property type="term" value="P:negative regulation of epithelial cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of hippo signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of hippo signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902174">
        <property type="term" value="P:positive regulation of keratinocyte apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060412">
        <property type="term" value="P:ventricular septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000030">
        <property type="entry name" value="Salvador family WW domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="11">
        <location>
            <begin position="323"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="386" mass="44622" checksum="04B16D5CD69283A9" modified="2020-06-17" version="1">MLSRKKTRAELSKPGEVQGKYVIKETSPLLRNLMPSFIRHGPTIPRRTDLCLLEPGSSSYAAGGDGAVSRNQSFLRTPVQRPPHEIVRRESNRLSAPSYLARSLADVPREYGVSSQSFLTEANSVTENGDAGSRHYYDHHFYNGQRRHQMGDHGQEEYRYYEHNTDLAQRMSQNQGRHSSGIGRVAATSLGNLTNHSSEDLPLPPGWSVDWTLRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESAEFGVYYVDHINKRAQYKHPCAPSVPRYDQPPPMTYQPQPAERSQPILVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELERIVKLYEAYRQALLSELENRKQRQQWYAQQQHGKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNN6</accession>
    <name>A0A670HNN6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein eS21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">40S ribosomal protein S21</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 40S small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HNN6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001558.1">
        <property type="protein sequence ID" value="ENSPMRP00000001469.1"/>
        <property type="gene ID" value="ENSPMRG00000001100.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017515"/>
    <dbReference type="OMA" id="RASIQIN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="65" mass="7144" checksum="C833E6BB8A6EBA93" modified="2020-06-17" version="1">MQNDAGEFVDLYVPRKCSASNWIIGAKDHASIQMNISEADKVTGSVNGQYKTYAICGAIRRMGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP57</accession>
    <name>A0A670HP57_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIN2/TERF1-interacting telomerase inhibitor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114594921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028581033.1">
        <property type="nucleotide sequence ID" value="XM_028725200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HP57"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001388.1">
        <property type="protein sequence ID" value="ENSPMRP00000001306.1"/>
        <property type="gene ID" value="ENSPMRG00000000979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594921"/>
    <dbReference type="KEGG" id="pmua:114594921"/>
    <dbReference type="GeneTree" id="ENSGT00940000170880"/>
    <dbReference type="OMA" id="KHQEQGL"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="358" mass="39571" checksum="B5936EA54A6AFADC" modified="2020-06-17" version="1">MAMLAEPRRKQKWSVDPRNSAWSKDESKFGQKMLEKMGWSKGKGLGAQEQGNTEHVKVQLKNNTLGLGAAANQEDNWIAHQDDFNQLLAELNNCHGQDAPEAASKEEKRTFSLEEKSKSARKRVHYVKFAKGKDLSSRSEDDLSCIFGKRQAKKTQAAAVGTESPKEGQKEEEDPSDEVDSGNTVTSALTVQEYFAKRMAKLKKAQREADFRTAESPPAMAEESECLVAQPMKRKYPKHGCSESEDGLEGPEAKCPRDLGSSEEVEKLNTQKKKKKRKKKKKSKHSSPGGGSLSCNGSQNGAQEKGSCGSGTSDAESNDSEEPRGKRKNKGEKLVRDAVADVKKLKKKKKRKKEKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP67</accession>
    <name>A0A670HP67_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HP67"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001399.1">
        <property type="protein sequence ID" value="ENSPMRP00000001316.1"/>
        <property type="gene ID" value="ENSPMRG00000000986.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162611"/>
    <dbReference type="OMA" id="IMINSCH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545:SF14">
        <property type="entry name" value="LIGAND-DEPENDENT COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545">
        <property type="entry name" value="TRANSCRIPTION FACTOR MLR1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="71" mass="8191" checksum="FFEF610E8A8D884A" modified="2020-06-17" version="1">MASPCGRQECSIERRGFRHQLDSWRHRLLRCVGFESILEGLFGPELLKDLSLFKVSFILAKITNEHAFISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQP4</accession>
    <name>A0A670HQP4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQP4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002132.1">
        <property type="protein sequence ID" value="ENSPMRP00000002008.1"/>
        <property type="gene ID" value="ENSPMRG00000001472.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="SHQANHD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000056">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000389">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000250">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001119">
        <property type="entry name" value="zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000564">
        <property type="entry name" value="zinc finger protein 699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF73">
        <property type="entry name" value="ZINC FINGER PROTEIN 572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025534579" description="C2H2-type domain-containing protein" evidence="13">
        <location>
            <begin position="25"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="465" mass="53929" checksum="6A29C08026788D66" modified="2020-06-17" version="1">MPSVFELFALLLLRLAGFWEMVGLESFLMTKCQLVSVFIAEGDELETKNKGDHDNVYTVREQNVNLESGERFSQRSQQKTDGEKKQYQCLQCGKNFSRKSNLTRHEIIHSEEKPYQCFDCGKSFKRSTDFLKHQTFHTGIKPYQCLECGKCLSRNNRLASHQRIHTGERPYPCLECGKSFRMSDSLTTHQRIHTGEKPYQCLECGKSFSFKHNLTSHQTLHTGEKPFQCLDCGKSFSRKDRLTFHRRIHTGEKPYQCLECGKSFSLKVNLTSHQTLHTGEKPYPCLECGKSFRLKQTLASHQTLHTGEKPYQCLECGKSFRLKQILTSHQTLHTGERPFQCLECGKRFSRSYHLTAHQRIHNGEKPYRCLECGRSFSQRSSLILHQRNSHERTASREKPYHCLECGKGFKWKKSLTSHQIIHTGEKPFECLECGKSFSWKESLTSHQRIHTGEKPHQCLECGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HSB4</accession>
    <name>A0A670HSB4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear protein localization protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NPLOC4</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Protein degradation; proteasomal ubiquitin-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer with UFD1. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion. Interacts with ZFAND2B; probably through VCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028570005.1">
        <property type="nucleotide sequence ID" value="XM_028714172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HSB4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002583.1">
        <property type="protein sequence ID" value="ENSPMRP00000002426.1"/>
        <property type="gene ID" value="ENSPMRG00000001757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588748"/>
    <dbReference type="KEGG" id="pmua:114588748"/>
    <dbReference type="CTD" id="55666"/>
    <dbReference type="GeneTree" id="ENSGT00390000018731"/>
    <dbReference type="OMA" id="KWSRTGR"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036501">
        <property type="term" value="C:UFD1-NPL4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000008">
        <property type="entry name" value="nuclear protein localization protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000084">
        <property type="entry name" value="nuclear protein localization protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000012">
        <property type="entry name" value="nuclear protein localization protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MPN" evidence="19">
        <location>
            <begin position="228"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="18">
        <location>
            <begin position="582"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="610" mass="68748" checksum="37B5B62D23A0FCC7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HU16</accession>
    <name>A0A670HU16_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SAMM50 sorting and assembly machinery component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SAMM50</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028584553.1">
        <property type="nucleotide sequence ID" value="XM_028728720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HU16"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002734.1">
        <property type="protein sequence ID" value="ENSPMRP00000002567.1"/>
        <property type="gene ID" value="ENSPMRG00000001840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596882"/>
    <dbReference type="KEGG" id="pmua:114596882"/>
    <dbReference type="CTD" id="25813"/>
    <dbReference type="GeneTree" id="ENSGT00390000011355"/>
    <dbReference type="OMA" id="KHPVARF"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000002">
        <property type="entry name" value="sorting and assembly machinery component 50 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.310:FF:000010">
        <property type="entry name" value="sorting and assembly machinery component 50 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.310">
        <property type="entry name" value="membrane protein fhac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="485" mass="54177" checksum="0E5AA22CD1F85C63" modified="2020-06-17" version="1">MHHSDLEVAPTLCILNIRKMFLTSLEPLPMSGPDFGAIGEEAELVEVEPETKQEILENKDVVVQHVHFDGLGRTKDDIIMYEIGDVFKAKDLIDVMRKSHEAREKLLRLGIFRQVDVLIDTCQGDDALPNGLDVTFEVTELRRLTGSYNTMVGNNEGSMVLGLKLPNIFGRAEKVTFQFSYGTKETSYGLSFFKPQPGHFERNFSLNLYKVTGQFPWSSLRETDRGISTEFNFPIWKTNHTLKWEGVWRELGCLARTASFSVREESGHSLKSSVSHAMVIDSRNSSILPRRGALLKINQELAGYTGGDVSFLKEDFELQFNKKLLWDSVLSTSLWGGMLVPIGDKPSSIADRFYLGGPTSVRGFSMYSIGPQSEGDYLGGEAYWAGGLHLYTPLPFRPGRGGFGDLFRTHFFLNAGNLCNLNYGEGPKAHLRKLAECIRWSYGAGIVLRLGNIARLELNYCIPMGVQSGDRICDGVQFGAGIRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXW5</accession>
    <name>A0A670HXW5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 63A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMEM63A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028580350.1">
        <property type="nucleotide sequence ID" value="XM_028724517.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028580351.1">
        <property type="nucleotide sequence ID" value="XM_028724518.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028580352.1">
        <property type="nucleotide sequence ID" value="XM_028724519.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028580353.1">
        <property type="nucleotide sequence ID" value="XM_028724520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HXW5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004243.1">
        <property type="protein sequence ID" value="ENSPMRP00000003972.1"/>
        <property type="gene ID" value="ENSPMRG00000002722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594617"/>
    <dbReference type="KEGG" id="pmua:114594617"/>
    <dbReference type="CTD" id="9725"/>
    <dbReference type="GeneTree" id="ENSGT00940000159576"/>
    <dbReference type="OMA" id="DPTQVIW"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF24">
        <property type="entry name" value="CSC1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="52"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="221"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="416"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="795" mass="91024" checksum="C40C815D9BF08123" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXY8</accession>
    <name>A0A670HXY8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HXY8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004867.1">
        <property type="protein sequence ID" value="ENSPMRP00000004563.1"/>
        <property type="gene ID" value="ENSPMRG00000003128.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154136"/>
    <dbReference type="OMA" id="CQMATRM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="483" mass="55238" checksum="A98F7E5489B8CDE6" modified="2020-06-17" version="1">ASFSIGQPQNSKKELADVISEPLAVIFENSWRTGEVPADWRRANVVPIFKKGKREDPNNYRPVSLTSIPGKILEQIIKQTVCEHLERNAVITNSQHGFLKNKSCQTNLISFFDRITSLVDEGNAVDVAYLDFSKAFDKVPHDILVKKLVKCGLDYATTQWICNWLTDRTQRVLINGSSSSWRRVTSGVPQGSVLGPVLFNIFINDLDDGLKGILIKFADDTKLGGVANTPEDRITLQNDLDRLENWAKANKMNFNREKCKVLHLGKKNERHKYKMGDTWLESSTCEKDLGVLVDHKLDMSQQCDAAAKKANAILGCINRSIASRSREVIVPLYSALVRPHLEYCVQFWAPQFKKDTDKLERVQRRATKMVKGLETMSYEERLRELGMFSLEKRRLRGDMIAMFKYIKGCHIEEGERLFSAAPDKRTRSNGSKLQERRFHLNIRKNFLTVRAVRQWNLLPRSVVESPSLEVFKQRLDNHMSGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HY62</accession>
    <name>A0A670HY62_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil domain containing 141</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HY62"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004944.1">
        <property type="protein sequence ID" value="ENSPMRP00000004634.1"/>
        <property type="gene ID" value="ENSPMRG00000003178.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000169289"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13926" checksum="35E6B26358F15A72" modified="2020-06-17" version="1">MSSNDSSDGPPSTTTVSSVLVQAGDCKIIIAILKCGDWVQLQLAESVPNLLEIGSNQEETKKLLQDHELLLAKLKEKDERRPIFCCMDVWKVCVYVEECFESQMWVIIYLSTIASIFVEKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZK9</accession>
    <name>A0A670HZK9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114597624</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028586468.1">
        <property type="nucleotide sequence ID" value="XM_028730635.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586469.1">
        <property type="nucleotide sequence ID" value="XM_028730636.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586470.1">
        <property type="nucleotide sequence ID" value="XM_028730637.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586471.1">
        <property type="nucleotide sequence ID" value="XM_028730638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HZK9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005360.1">
        <property type="protein sequence ID" value="ENSPMRP00000005031.1"/>
        <property type="gene ID" value="ENSPMRG00000003455.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597624"/>
    <dbReference type="KEGG" id="pmua:114597624"/>
    <dbReference type="GeneTree" id="ENSGT00940000157650"/>
    <dbReference type="OMA" id="PHIQACR"/>
    <dbReference type="OrthoDB" id="9933182at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025550205" description="Claudin" evidence="9">
        <location>
            <begin position="30"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="220" mass="23982" checksum="FE9949074757D3B7" modified="2020-06-17" version="1">MVSSAFQISALLLAFLGLILLLVASVSNCWKFSSPSTTLITASWIYEGLWMNCVATSLGSVQCKKFFSLLSLETYIQACRALMITSLILGMCGTLLTLLGLKCTQLGSNSENAKSKIAMLGGMVFILAGLSSMVAISWYAERITAQFFDSFYGGTKYELGYALYLGWAGSLLSILGGIFLTCSACKEKHRDYKYAATRQGKDARIYIKQSETVTSAKDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZM5</accession>
    <name>A0A670HZM5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TSPAN14</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028585059.1">
        <property type="nucleotide sequence ID" value="XM_028729226.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028585060.1">
        <property type="nucleotide sequence ID" value="XM_028729227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HZM5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004920.1">
        <property type="protein sequence ID" value="ENSPMRP00000004612.1"/>
        <property type="gene ID" value="ENSPMRG00000003159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597112"/>
    <dbReference type="KEGG" id="pmua:114597112"/>
    <dbReference type="CTD" id="81619"/>
    <dbReference type="GeneTree" id="ENSGT00940000159235"/>
    <dbReference type="OMA" id="QRMNHCC"/>
    <dbReference type="OrthoDB" id="2014092at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097197">
        <property type="term" value="C:tetraspanin-enriched microdomain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03159">
        <property type="entry name" value="TM4SF9_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000001">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF261">
        <property type="entry name" value="TETRASPANIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="270" mass="30603" checksum="F7099EF0BBA84032" modified="2020-06-17" version="1">MHYYRYSSAEVSCWYKYLLFSYNIIFWLAGVAFLGAGLWAWSEKGVLSDISKMTRLHGFDPVVLIVFVGGVMFILGFAGCVGALRENICLLKFFCGTIVLIFVLELAAAVLAFLFQDWVRDRVETFFKNNIKSYRDDIDLQNLIDSLQKMNNCCGAQEPNDWNLNIYFNCSSTSKSRERCGVPFSCCIQDPAQKVVNTQCGYDVRNLPVSAWGERIYTRGCIPALEAWLPRNIYIVAGIFVAISLLQIFGIFLARTLICDIEAVKAGYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0D1</accession>
    <name>A0A670I0D1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione S-transferase omega</fullName>
            <shortName evidence="8">GSTO</shortName>
            <ecNumber evidence="8">1.20.4.2</ecNumber>
            <ecNumber evidence="8">1.8.5.1</ecNumber>
            <ecNumber evidence="8">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Monomethylarsonic acid reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GSTO1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:15969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:33409"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.20.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.2" evidence="8"/>
    <dbReference type="EC" id="1.8.5.1" evidence="8"/>
    <dbReference type="EC" id="2.5.1.18" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028586176.1">
        <property type="nucleotide sequence ID" value="XM_028730343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I0D1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005736.1">
        <property type="protein sequence ID" value="ENSPMRP00000005384.1"/>
        <property type="gene ID" value="ENSPMRG00000003685.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597506"/>
    <dbReference type="KEGG" id="pmua:114597506"/>
    <dbReference type="CTD" id="9446"/>
    <dbReference type="GeneTree" id="ENSGT00940000155351"/>
    <dbReference type="OMA" id="PDADIHP"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050610">
        <property type="term" value="F:methylarsonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071243">
        <property type="term" value="P:cellular response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019852">
        <property type="term" value="P:L-ascorbic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051280">
        <property type="term" value="P:negative regulation of release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051281">
        <property type="term" value="P:positive regulation of release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014810">
        <property type="term" value="P:positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010881">
        <property type="term" value="P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042178">
        <property type="term" value="P:xenobiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03184">
        <property type="entry name" value="GST_C_Omega"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03055">
        <property type="entry name" value="GST_N_Omega"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000075">
        <property type="entry name" value="Glutathione S-transferase omega-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000100">
        <property type="entry name" value="Glutathione S-transferase omega-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="9">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="10">
        <location>
            <begin position="134"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="270" mass="30907" checksum="83E37D759820D54C" modified="2020-06-17" version="1">MWAETVGRLRGGSLSSVSITCLLTTPGRMSGEFARSLGKGSSAPGPVPEGVIRLYSMRYCPFAQRTRLVLKAKGINHEIVNINLKNKPDWFFEKSPFGLVPVLETSKGQLIYESPITCEYLDEAYPEKKLYPADPYEKAYQKMLLEQFSKLTPLCHKYLLAVRSGDNASAVKNELRERLLKLEEILVNRKTKYFGGNTVSMIDYLIWPWFERMEPYELYDCLDHTPELKHWVEAMRLDPAVKATVNDAQTYKGFLELYLKNSHEACDYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I149</accession>
    <name>A0A670I149_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I149"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006027.1">
        <property type="protein sequence ID" value="ENSPMRP00000005663.1"/>
        <property type="gene ID" value="ENSPMRG00000003820.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154335"/>
    <dbReference type="OMA" id="EFAVEIY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14510">
        <property type="entry name" value="PTP_VSP_TPTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1110:FF:000004">
        <property type="entry name" value="Voltage-sensor containing phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045102">
        <property type="entry name" value="PTP_VSP_TPTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF60">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="11">
        <location>
            <begin position="171"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="256"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="12">
        <location>
            <begin position="354"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="491" mass="57277" checksum="45ECF98E19CF85BA" modified="2020-06-17" version="1">MFSLEKRRLRGDMIAMFKYIKGLTVFLLFFPIPFACFRLFGIVLIFVDISLVILSLMIAHKYHSLDVMIGNISLAIAFFFLFDVLLRVSIEGFEKYFESKLNILDAIIVGVTLLIDFVYAVSDFSGISLIPRAVIIFRILRVIILIRIFRLASEKERLEKLTRRIVSENKRRYTKDGFDLDLTYVTARVIAMSFPSSGKQSWYRNPIKEVARFLDTKHEGHYKVYNLCSEQGYDPKIFHYRVERIFIDDHNVPTLEEMVQFTHSVMEWMLQDENNVIAIHCKGGKGRTGTMICIWLIENSLFESAKESLQYFGKRRTDESTSSKFQGVETPSQNRYVEYYATLKWKYNLQLPKAKPLEIKSIKLYAIHGVGKGNGSDLRVKIIMEKQVVFHCVCATQENCQLFFDGENDWVVIAFECCPVVSKDVKVRFESSSSAIPKGYDDCAFFFWFHTAFVEDNRLYLSRNEIDNLHKPRMWKTFREDFAVELHFGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1E3</accession>
    <name>A0A670I1E3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I1E3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006133.1">
        <property type="protein sequence ID" value="ENSPMRP00000005768.1"/>
        <property type="gene ID" value="ENSPMRG00000003919.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154420"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CenT-Element_Derived"/>
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        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I2J7</accession>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005705.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="526" mass="59015" checksum="E08E7F9BAACCC9BF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3R6</accession>
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            <fullName evidence="4">L-amino-acid oxidase</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <cofactor evidence="1">
            <name>FAD</name>
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        </cofactor>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family. FIG1 subfamily.</text>
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        <property type="nucleotide sequence ID" value="XM_028728901.1"/>
    </dbReference>
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        <property type="gene ID" value="ENSPMRG00000004394.1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:polyamine oxidase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of spermidine biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:putrescine biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:putrescine catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046208">
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF405">
        <property type="entry name" value="PEROXISOMAL N(1)-ACETYL-SPERMINE_SPERMIDINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="512" mass="56093" checksum="4A79179B71F8E80B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I404</accession>
    <name>A0A670I404_PODMU</name>
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        <submittedName>
            <fullName evidence="14">Neuropeptides B and W receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NPBWR2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="neuropeptides B/W receptor type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009150">
        <property type="entry name" value="Neuropept_B/W_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF18">
        <property type="entry name" value="NEUROPEPTIDES B_W RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NRPEPTIDEWR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="41"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006190.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="333" mass="37321" checksum="6E838978887D8AB3" modified="2020-06-17" version="1">MGSHLGEDGDLNATCNGTGDPCGTGNVTSYNLTSHEQSPDFYVVLPVIYSVICAVGLTGNTAVIYVILKAPKMKTVTNMFILNLAIADDLFTLVLPINIAEHLLHYWPFGEVLCKVILSIDHYNIFSSIYFLTVMSIDRYLVVLATVSSKRMPHRTYRAARIISFGIWFLVTLIVSPFFVFANVYEDGLGIKSCGLNFPRPEQFWFKASRIYTLILAFAIPVSTICILYSMMLYKLRNMRLNSNAKALDKAKKKVTIMVFIVMAVCLFCWTPFHLATIVALTTDLPQTPVVIGASYFITSLSYANSCLNPFLYAFLDDSFQKSFRKMLECRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4P4</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="9">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">XKR4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment.</text>
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    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the XK family.</text>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I4P4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006827.1">
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        <property type="gene ID" value="ENSPMRG00000004346.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114600607"/>
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    <dbReference type="OMA" id="CQQPGAD"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="XK-rel"/>
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        <property type="entry name" value="XK-related_scramblase"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF16">
        <property type="entry name" value="XK-RELATED PROTEIN 4"/>
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    <proteinExistence type="inferred from homology"/>
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            <end position="120"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="409"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="666" mass="72627" checksum="DB0C2A482FA46807" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4T2</accession>
    <name>A0A670I4T2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional lysine-specific demethylase and histidyl-hydroxylase</fullName>
            <ecNumber evidence="15">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RIOX1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54256"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:13840"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:138021"/>
            <dbReference type="EC" id="1.14.11.79"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:54257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42033"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl-[protein] + 2-oxoglutarate + O2 = L-lysyl-[protein] + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:60924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:60925"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="15">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROX family. NO66 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_028580193.1">
        <property type="nucleotide sequence ID" value="XM_028724360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I4T2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006930.1">
        <property type="protein sequence ID" value="ENSPMRP00000006505.1"/>
        <property type="gene ID" value="ENSPMRG00000004393.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594532"/>
    <dbReference type="KEGG" id="pmua:114594532"/>
    <dbReference type="CTD" id="79697"/>
    <dbReference type="GeneTree" id="ENSGT00390000000083"/>
    <dbReference type="OMA" id="YLEYMGV"/>
    <dbReference type="OrthoDB" id="425950at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036139">
        <property type="term" value="F:peptidyl-histidine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045738">
        <property type="term" value="P:negative regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000013">
        <property type="entry name" value="Ribosomal oxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1500:FF:000001">
        <property type="entry name" value="ribosomal oxygenase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.40:FF:000001">
        <property type="entry name" value="ribosomal oxygenase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1500">
        <property type="entry name" value="JmjC domain-containing ribosomal oxygenase (ROX), dimer domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="NO66-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049043">
        <property type="entry name" value="WHD_RIOX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="MINA53 MYC INDUCED NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096:SF8">
        <property type="entry name" value="RIBOSOMAL OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21233">
        <property type="entry name" value="WHD_RIOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 15" id="KW-0408">Iron</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="244"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="591" mass="66750" checksum="A6E32AC21814DFD5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6L9</accession>
    <name>A0A670I6L9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rabenosyn, RAB effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RBSN</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I6L9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007898.1">
        <property type="protein sequence ID" value="ENSPMRP00000007381.1"/>
        <property type="gene ID" value="ENSPMRG00000004989.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007159"/>
    <dbReference type="OMA" id="QKMYEFI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008437">
        <property type="term" value="F:thyrotropin-releasing hormone activity"/>
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        <property type="project" value="InterPro"/>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6M2</accession>
    <name>A0A670I6M2_PODMU</name>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="3">Belongs to the dystrophin family. Dystrobrevin subfamily.</text>
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        <location>
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            <end position="300"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <sequence length="757" mass="85431" checksum="8F549ED4950747C0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9A2</accession>
    <name>A0A670I9A2_PODMU</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I9A2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008801.1">
        <property type="protein sequence ID" value="ENSPMRP00000008234.1"/>
        <property type="gene ID" value="ENSPMRG00000005574.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160750"/>
    <dbReference type="OMA" id="YHESTHM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RNase_HI_RT_Bel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41694">
        <property type="entry name" value="ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41694:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="105"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="375"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="628"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="657" mass="72644" checksum="01050FE272B1679A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9I5</accession>
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        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="11" type="primary">ASPG</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A670I9I5"/>
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        <property type="protein sequence ID" value="ENSPMRP00000008356.1"/>
        <property type="gene ID" value="ENSPMRG00000005655.1"/>
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    <dbReference type="OMA" id="CDVGVIP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Asparaginase homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="10">
        <location>
            <begin position="274"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008356.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="626" mass="67866" checksum="4695076885B377F6" modified="2020-06-17" version="1"> </sequence>
</entry>
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                <person name="Marsik P."/>
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                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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        <subcellularLocation>
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        </subcellularLocation>
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    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    </dbReference>
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    </dbReference>
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            <end position="705"/>
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="333"/>
        </location>
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    </feature>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="343"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
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        </location>
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    </feature>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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</entry>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
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                <person name="Bellati A."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IH33</accession>
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    </protein>
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        <lineage>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Bellati A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1844" mass="206447" checksum="6DFD1AF17507B566" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIZ6</accession>
    <name>A0A670IIZ6_PODMU</name>
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        <submittedName>
            <fullName evidence="12">Free fatty acid receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114602377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IIZ6"/>
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        <property type="protein sequence ID" value="ENSPMRP00000011609.1"/>
        <property type="gene ID" value="ENSPMRG00000007779.1"/>
    </dbReference>
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    <dbReference type="OMA" id="KFKSERR"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cellular response to fatty acid"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013312">
        <property type="entry name" value="GPR40-rel_orph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45822:SF5">
        <property type="entry name" value="FREE FATTY ACID RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45822">
        <property type="entry name" value="FREE FATTY ACID RECEPTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
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            <begin position="32"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="401" mass="44950" checksum="C808BA71F2AEF4A5" modified="2020-06-17" version="1">WGGGRTQRYHGNGHKASYPCHYIITFLTGLPSNLLAGYAFLRKVRQKATPMDVFLLNLTISDLILLLILPFKMAEASSDVPWPLPAFLCPLTNFCFYSSIYSSTLFLTGVSIERYLCIAYPIKFKSERRPTYVIVASLFFWFLACFHCSIIYTVQYHPEAQPMSHNSTCYESFSNGQLKILLPVRLQLCILLFFLPFIITLFCYIRVIRILTSLPHIKPQRKKRAVGLAVATLLNFAVCFGPFNISHLVGYIQFWSPEWRVYGFLLSSFNSTLDPVIFYFSSTAIQQTFAHCWEATHCKLLTLASRWSLPCCRTAGEPNKEAGAGGISTSGELAGAAIPTEASFVQTARACEIRALSPQQVQVLHTGLLGYTEAILHCPDLQEYKEQNGADTNLPDGSDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJ98</accession>
    <name>A0A670IJ98_PODMU</name>
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        <recommendedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IJ98"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012917.1">
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        <property type="gene ID" value="ENSPMRG00000008082.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156683"/>
    <dbReference type="OMA" id="VITILVX"/>
    <dbReference type="Proteomes" id="UP000472272">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF73">
        <property type="entry name" value="PROTOCADHERIN GAMMA-B3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CADHERIN_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="102"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="219"/>
            <end position="324"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="442" mass="48964" checksum="B8FB073054FAEDD8" modified="2020-06-17" version="1">ITFVLNSVSENTPTGTVIAILNVQDRDSGVNGEVMCSIPNSLPFQLKKTMDNFYTLVTDRALDREQYNITITATDKGTPPLSTHKTISIQISDINDNPPAFEKSSYTAYVPENNPSGASIFHIKASDPDLDRNARITYSILLSNIKDLPLSSYVSINSETGIIYAQRSFDYEQFREFQIQVKAQDGGSPPLNSSATVTVCVLDRNDNAPQILYPSQSTEGSPFFEMVPRSAESGYLVTKVVAVDSDSGHNAWLSFHLLQATEPSLFSIGSHTGEVQTVRALLERDAVKQRLVILVKDNGHPPLSATTTLSLVFAENFQEALPEMNSQPNDSEYQSDLQFYLVLALTLVSFLFLVTVILTILMKLRRSRNPTFLQCFIPDPHSKAGAIFPPNYEDGTLPYSYQVCLSSESRRNELTFLQPTVQIAENILCNVTSKGSFSCHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJA2</accession>
    <name>A0A670IJA2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucose-fructose oxidoreductase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GFOD2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Promotes matrix assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IJA2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012922.1">
        <property type="protein sequence ID" value="ENSPMRP00000012103.1"/>
        <property type="gene ID" value="ENSPMRG00000008087.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156501"/>
    <dbReference type="OMA" id="YVGEIQV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000025">
        <property type="entry name" value="Glucose-fructose oxidoreductase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000233">
        <property type="entry name" value="Glucose-fructose oxidoreductase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF8">
        <property type="entry name" value="GLUCOSE-FRUCTOSE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="10">
        <location>
            <begin position="156"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="442" mass="49098" checksum="80756C5DEE2121F4" modified="2020-06-17" version="1">MKQDAKKLCFYALVLPLGTELEKEYNMKMLPGVGVFGTGSSARVLVPLLRAEGFSIKALWGKTEEEAKQLAEEMNISFYTSRTDDVLLHQDVDLVCINIPPPLTRQIAVKALGIGKNVICEKAATSVDAFRMVTAARYYPKLMSIVGNVLRFLPAFIKMKQLIEEHYVGNVLVCDVRVYWGSLLSHKYNWICDELMGGGGLHTMGTYIIDLLTHLTSRKAEKVHGLLKTFVKQNSAINGIRHVTSDDFCFFQMLMSGGICSTVTLNFNMPGSFVHEVMIVGSAGRLIARGTDLYGQKNTAPQEELLFADSLNVHAGLSEKGFKDIPLLYLKGMVYLVQALRQSFQDQEDQRTWDPKPVAMAASFEDGLYMQSVVDAIKKSSRSGDWESVEVMTEEPDANQNLLAKSSMILAASHFIWHSGIAHELQMSGDQQRDQLAPSIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJJ5</accession>
    <name>A0A670IJJ5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized LOC114597663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114597663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028586571.1">
        <property type="nucleotide sequence ID" value="XM_028730738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IJJ5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012260.1">
        <property type="protein sequence ID" value="ENSPMRP00000011477.1"/>
        <property type="gene ID" value="ENSPMRG00000007682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597663"/>
    <dbReference type="KEGG" id="pmua:114597663"/>
    <dbReference type="GeneTree" id="ENSGT00990000210524"/>
    <dbReference type="OrthoDB" id="9033483at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004865">
        <property type="entry name" value="HSR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000770">
        <property type="entry name" value="SAND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043563">
        <property type="entry name" value="Sp110/Sp140/Sp140L-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46386">
        <property type="entry name" value="NUCLEAR BODY PROTEIN SP140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46386:SF1">
        <property type="entry name" value="NUCLEAR BODY PROTEIN SP140-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03172">
        <property type="entry name" value="HSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00258">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51414">
        <property type="entry name" value="HSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSR" evidence="4">
        <location>
            <begin position="85"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SAND" evidence="3">
        <location>
            <begin position="201"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="HSR" evidence="4">
        <location>
            <begin position="324"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="SAND" evidence="3">
        <location>
            <begin position="477"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="586" mass="65846" checksum="ED55EC3DB39EEFF9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJV6</accession>
    <name>A0A670IJV6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TMEM30A</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028578637.1">
        <property type="nucleotide sequence ID" value="XM_028722804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IJV6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012359.1">
        <property type="protein sequence ID" value="ENSPMRP00000011572.1"/>
        <property type="gene ID" value="ENSPMRG00000007751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593884"/>
    <dbReference type="KEGG" id="pmua:114593884"/>
    <dbReference type="CTD" id="55754"/>
    <dbReference type="GeneTree" id="ENSGT00390000004660"/>
    <dbReference type="OMA" id="IPWSMFN"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015247">
        <property type="term" value="F:aminophospholipid flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061092">
        <property type="term" value="P:positive regulation of phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036010">
        <property type="term" value="P:protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006855">
        <property type="term" value="P:xenobiotic transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF17">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="379" mass="42378" checksum="3660785F30F37C2C" modified="2020-06-17" version="1">MAMNFNAKEEVDGQVPGSSGVGGAGVGVSVAGGAGVKSRKPDNTAFKQQRLPAWQPILTAGTVLPAFFVIGLIFIPIGIGIFVTSNNIREYEIDYTGTEPGSPCNKCLNVSWNNTPSCTCTIHFTLDQPFESNVFMYYGLSNFYQNHRRYVKSRDDSQLNGDNNSLHHPSKECEPYRTSGDKPIAPCGAIANSMFNDTLTLFRIDRNETKYIRIPLTKQGIAWWTDKNVKFRNPTGPTKDLAILFQGTAKPVNWPKPVYELDKDADNNGFINEDFIVWMRTAALPTFRKLYRLIERPDNLRPTLPAGNYSLEIEYNYPVHSFDGRKRMILSTISWMGGKNPFLGIAYITVGSICFFLGVVLLIIHHKYGNRNNSADIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKV7</accession>
    <name>A0A670IKV7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Protein SYS1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SYS1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein trafficking. May serve as a receptor for ARFRP1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ARFRP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028590872.1">
        <property type="nucleotide sequence ID" value="XM_028735039.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028590873.1">
        <property type="nucleotide sequence ID" value="XM_028735040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IKV7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013540.1">
        <property type="protein sequence ID" value="ENSPMRP00000012678.1"/>
        <property type="gene ID" value="ENSPMRG00000008474.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599567"/>
    <dbReference type="KEGG" id="pmua:114599567"/>
    <dbReference type="CTD" id="90196"/>
    <dbReference type="GeneTree" id="ENSGT00940000154347"/>
    <dbReference type="OMA" id="EYEMVGM"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016973">
        <property type="entry name" value="Integral_membrane_SYS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031402">
        <property type="entry name" value="SYS1_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR031402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="156" mass="17699" checksum="0E0C815F05769F95" modified="2020-06-17" version="1">MAPQFRSYVWDPALILSQITLMQAIYYSSLGLWLAVVDSLVHNSPSLDQIFNYEVLGFSTSPGRLAMMAFILNALSCAIGLLYFIRRGKQCLDFTVTIHFFHLLGCWIYNAHFPTALTWWLVHTVCTALMAVIGEYLCMRTELKEIPLNSTPKSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILE0</accession>
    <name>A0A670ILE0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670INI6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014629.1">
        <property type="protein sequence ID" value="ENSPMRP00000013693.1"/>
        <property type="gene ID" value="ENSPMRG00000009179.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182901"/>
    <dbReference type="OMA" id="FDVIKMP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044391">
        <property type="term" value="C:ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9077" checksum="E545C1AF36DAE014" modified="2020-06-17" version="1">MKKIEDNNTLMFIVDMKANKHHIKQAVKKLYNTDVAKVNLLIRPDGEKKAYVCLAPDYDVLDLGTIRADAHSQKWSFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQB1</accession>
    <name>A0A670IQB1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 883-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114592100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028575819.1">
        <property type="nucleotide sequence ID" value="XM_028719986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IQB1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014830.1">
        <property type="protein sequence ID" value="ENSPMRP00000013876.1"/>
        <property type="gene ID" value="ENSPMRG00000009307.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592100"/>
    <dbReference type="KEGG" id="pmua:114592100"/>
    <dbReference type="GeneTree" id="ENSGT01150000286944"/>
    <dbReference type="OMA" id="VELLYCQ"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002239">
        <property type="entry name" value="Zinc finger protein 226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000212">
        <property type="entry name" value="zinc finger protein 382 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000895">
        <property type="entry name" value="Zinc finger protein 597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000520">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="195"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="486" mass="54853" checksum="3E900517A05FCE6B" modified="2020-06-17" version="1">MEAPPQPRTSGIRKEYPCPECGRNFKRNSHLVRHKRLHTGEKPYKCPECGKSFRQSTDVNTHRRIHTGETPFHCNQCGKSFRYRTGLVKHVRGHEEEKAKACRSCLECGKIISGTLVSVASQTSHAVGRSHKCPDCEKNTQESSHLVVHIPGRATEENYMCPDCGEGFCHSFQLIGHRNLHARFQIPNPGTLCGLEPGVAPLPSDHQDEEQRESPGSICRACDDAVPTEREEKDPSSHERLSRTLLGRLQILDPRRKEASKARPGFSRGQWKRPAARGRESAEDGSAASPVCERFLRSERRHLCFMCGKRFRYESHLVTHERIHTGEKPFECSTCHKSFRDRSDLSKHQKTHSADKPYKCLDCGKSFHHQLTFIRHQRLHPRESSSCDPSRVYFAILPSYHVGAEMSIGDGTETPESLGFPFKQKAQNISPVELLYCQETFDLVLHKKTQPCVSSTAATHQRAGGRSEMEKAQRTISGDAVGVCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQD1</accession>
    <name>A0A670IQD1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 18 open reading frame 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C18orf32</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0729 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IQD1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015323.1">
        <property type="protein sequence ID" value="ENSPMRP00000014348.1"/>
        <property type="gene ID" value="ENSPMRG00000009571.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018741"/>
    <dbReference type="OMA" id="NHRIFRF"/>
    <dbReference type="OrthoDB" id="10062823at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026776">
        <property type="entry name" value="UPF0729_C18orf32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13456">
        <property type="entry name" value="UPF0729 PROTEIN C18ORF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13456:SF0">
        <property type="entry name" value="UPF0729 PROTEIN C18ORF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14975">
        <property type="entry name" value="DUF4512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="91" mass="10390" checksum="78DA4494953629EA" modified="2020-06-17" version="1">MVCIPCIVIPVLLWVYKRFLEPYLYPIISPFIKRIWPKRAVQETAKKDQKGSAENRRELYDSMDDSKTESNGIVNGFAESGPPGVSEKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IR35</accession>
    <name>A0A670IR35_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Growth arrest-specific protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GAS8</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IR35"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014924.1">
        <property type="protein sequence ID" value="ENSPMRP00000013964.1"/>
        <property type="gene ID" value="ENSPMRG00000009337.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009477"/>
    <dbReference type="OMA" id="MKHLQYE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903566">
        <property type="term" value="P:positive regulation of protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039308">
        <property type="entry name" value="GAS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025593">
        <property type="entry name" value="GAS8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31543">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31543:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13851">
        <property type="entry name" value="GAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Growth arrest-specific protein 8" evidence="15">
        <location>
            <begin position="225"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="251"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="481" mass="56831" checksum="79FF61D973BE5FE5" modified="2020-06-17" version="1">APKKKGEKKGGKKKGAKSPVVDVVSPEGMTKEQLEEHMGRIREELDREREERNYFQLERDKIHTFWEITRRQLDEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNITELKAESTVSMKLAQKDHRSQEMELRKDMRTLKVELKEQELSNEMVVKNLRLKQQEDITRLRNDFERQVKEIEAKYEKKMRVLRDELDLRRKTEIHEIEERKNGQINTLMKNHEKAFSDIKNYYNDVTLNNLALINTLKEQMEEMKKKEDHLEKEMAEVLLQNKKLVEPLQRAREEVAELQKKLAHYEKDKAMLHHTHARLKVTEKELKDLQWEHEVLQQRFIRVQDERDDLYQKFTKAINEVQQKTGFKNLLLERKLLGLSNILEKKEVQLNEVLAATNLDPGALSVVTRKLEDVLDSKNNAIKDLQYELARVCKAHNDLLRTYEAKLTAFGIPLDNLGFKPLETSVIGHTLGQGPAGFVSTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISG9</accession>
    <name>A0A670ISG9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhotekin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RTKN2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670ISG9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016099.1">
        <property type="protein sequence ID" value="ENSPMRP00000015068.1"/>
        <property type="gene ID" value="ENSPMRG00000010055.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157470"/>
    <dbReference type="OMA" id="GNHKMVI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13249">
        <property type="entry name" value="PH_rhotekin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF21">
        <property type="entry name" value="RHOTEKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="377"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="674" mass="75231" checksum="48FC0292C8BA2BD7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITL6</accession>
    <name>A0A670ITL6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ATP2B1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="RefSeq" id="XP_028603407.1">
        <property type="nucleotide sequence ID" value="XM_028747574.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028603408.1">
        <property type="nucleotide sequence ID" value="XM_028747575.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028603410.1">
        <property type="nucleotide sequence ID" value="XM_028747577.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028603411.1">
        <property type="nucleotide sequence ID" value="XM_028747578.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028603412.1">
        <property type="nucleotide sequence ID" value="XM_028747579.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028603413.1">
        <property type="nucleotide sequence ID" value="XM_028747580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ITL6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015520.1">
        <property type="protein sequence ID" value="ENSPMRP00000014527.1"/>
        <property type="gene ID" value="ENSPMRG00000009626.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605901"/>
    <dbReference type="KEGG" id="pmua:114605901"/>
    <dbReference type="CTD" id="490"/>
    <dbReference type="GeneTree" id="ENSGT00940000158686"/>
    <dbReference type="OMA" id="YRMYVKG"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098684">
        <property type="term" value="C:photoreceptor ribbon synapse"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990034">
        <property type="term" value="P:calcium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001818">
        <property type="term" value="P:negative regulation of cytokine production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051481">
        <property type="term" value="P:negative regulation of cytosolic calcium ion concentration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030501">
        <property type="term" value="P:positive regulation of bone mineralization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051928">
        <property type="term" value="P:positive regulation of calcium ion transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900076">
        <property type="term" value="P:regulation of cellular response to insulin stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003056">
        <property type="term" value="P:regulation of vascular associated smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF245">
        <property type="entry name" value="PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
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</entry>
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                <person name="While G.M."/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUZ3</accession>
    <name>A0A670IUZ3_PODMU</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IUZ3"/>
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        <property type="protein sequence ID" value="ENSPMRP00000015745.1"/>
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        <location>
            <begin position="224"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="448" mass="51251" checksum="F676CDAC824A05E1" modified="2020-06-17" version="1">MATKLLRFLARSSHKTSHCQHLHKYGLSASSNNLQGVSSNSLLACRSISMCIPEATTSCLSRLCVQTKEWQRPQANVPTAAKTVNYLSMHVCPPHREQFCALKNTSFKHNAKCMGKFMDIPNRHYSVLSSSKIMPNQHILPAKRLPKASRTKQPSRANLPLPSETEDLMQCTAFATAEEYNLGTLCHDLTSYGYVEITTLPRDAANVLVIGTESSAKEYDPGIIFFFREGSVVFWNVEEKTMKSIMQVLERHEIQPYEVALVHWENEEMNYRLGEAQSKLHRGEILINSELDPDEITLEKFAFSNALCLSVKLAIWESSLDNFVESIQSIPEILKSRRKVKLSHADVMQKIGELFALRHRINLSSDLLMTPDFYWDREHLEQLYDKTCQFLSISRRVKVVNEKLQHCTELTDLMRNHLSEKHALRLEWMIVILITIEVILQQCAAVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWY2</accession>
    <name>A0A670IWY2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="85" mass="10144" checksum="FE05CC74B701CBA1" modified="2020-06-17" version="1">KKWSKGKVRDKLNNLVLFDKATYDKLRKEVPNYKLIPPAAELLSKGRIKLVSKHRAQVIHTRNTKRGVHQLWMRMHERFLVKWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IYE3</accession>
    <name>A0A670IYE3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IYE3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018284.1">
        <property type="protein sequence ID" value="ENSPMRP00000017168.1"/>
        <property type="gene ID" value="ENSPMRG00000011383.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="485" mass="54709" checksum="3C0E4912E292A565" modified="2020-06-17" version="1">MHMLDINMILLLILIPWEGEGSLNLTKFAKYGFSHDHNMWVGLAEMVANVANRTNCLVCSLGPDDSEGGMPLLPIPLDAIGMVSEIPHQTEIQNFPGWNSTKPLRVIPVQGEFCVHKSSDAADSTMIGSSHCHYTWDYFKNTWAHGTTYRTRNTLPCAPPFIHAWKVVWNITVTEKGNLTYCTVNSLPLLIFRLLYSTYQKPQTRWLWWICGEWAYKKLPSKWSGTCFLGWVLPPMWIMPTSSAKRTRRNADISRIAGGSTQSWSGTDDWPPERIIAYYDPASWNPGELIQGARDPIYNLNRIIRLQAVVELVTNATAQSLRLIAQQLDESRAAILQLKMGMDYVLARQGGLCGVLNLTGNACCFNISDNGEAIRVLATKMENIAHVPVQTWEGWDMGWLTNWLPNVTGLKGILLSCLFFLTVVVMVLCMMPCIISCFRSTISKMVSNETLPHIMALYRALPQEYDEGQAIKDTWCKVLELERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZD6</accession>
    <name>A0A670IZD6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Scleraxis bHLH transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCX</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IZD6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018480.1">
        <property type="protein sequence ID" value="ENSPMRP00000017355.1"/>
        <property type="gene ID" value="ENSPMRG00000011480.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161897"/>
    <dbReference type="OMA" id="FYHHGGG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cartilage development"/>
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        <property type="term" value="P:skeletal muscle cell differentiation"/>
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        <property type="term" value="P:tendon cell differentiation"/>
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        <property type="term" value="P:tissue homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd18951">
        <property type="entry name" value="bHLH_TS_scleraxis"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
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    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF5">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR SCLERAXIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="154"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="202" mass="22086" checksum="688B6D25CE3EF661" modified="2020-06-17" version="1">MSSFAMLRSAPSRFLYPDISMLSEDEEDGSESSGSEDKPYHLDAGGYGLKSSKRRSKKANRINREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYISHLGNVLLVGDACGDGQPCHTTPAFFHHSSGGSSSSPPMRESENSQPKQICTFCLSNQRKMVSPGVSWLAGGAGGWGWKEHKETAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZQ1</accession>
    <name>A0A670IZQ1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SLC9A4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IZQ1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018837.1">
        <property type="protein sequence ID" value="ENSPMRP00000017693.1"/>
        <property type="gene ID" value="ENSPMRG00000011679.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160774"/>
    <dbReference type="OMA" id="TFSPWNC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:gastric acid secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002068">
        <property type="term" value="P:glandular epithelial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070634">
        <property type="term" value="P:transepithelial ammonium transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001953">
        <property type="entry name" value="NHE-2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032103">
        <property type="entry name" value="NHE_CaM-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF103">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16644">
        <property type="entry name" value="NEXCaM_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01086">
        <property type="entry name" value="NAHEXCHNGR2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025573000" description="Sodium/hydrogen exchanger" evidence="14">
        <location>
            <begin position="24"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="15">
        <location>
            <begin position="74"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/hydrogen exchanger regulatory region" evidence="16">
        <location>
            <begin position="571"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="754" mass="85232" checksum="E41290999352E99A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J135</accession>
    <name>A0A670J135_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Monocarboxylate transporter 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 16 member 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114608079</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028607828.1">
        <property type="nucleotide sequence ID" value="XM_028751995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J135"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019059.1">
        <property type="protein sequence ID" value="ENSPMRP00000017910.1"/>
        <property type="gene ID" value="ENSPMRG00000011816.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114608079"/>
    <dbReference type="KEGG" id="pmua:114608079"/>
    <dbReference type="GeneTree" id="ENSGT00940000159372"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000163">
        <property type="entry name" value="Putative monocarboxylate transporter 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF19">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="441" mass="46868" checksum="04EC9A6EAC597ED7" modified="2020-06-17" version="1">MSPRVYSEPPDGGWGWAITLACFMQSALVFGVTRPFGIFFVEFMAYFDEPSSATSWISSITVATSKFTSPLAGALATQYGERPVAIAGGLLSGLGYFLASFATNLAQLYIFIGMFTGIGGTFALWPSLALLSRYFERRRPLATSLALSGAGVASLALSPLFQFLVDLYGWRGALLLVSGMVFHLLPCGALLRPLALPEDDALAAPPEQAVSWRHRLSSLFGLSLLRHRGFMTYTCCGVLNAAGFFVPLVHLVPHARELDFDEYQAAFLASAVGVADIGGRVACTWLVTCGPLRLCHHLTLWSFLTGVSVLAVPLGRSYGAVLAISACYGFLAGAVLPLRVSTLVEIVGPARIMGAIGLINLMESVGALSGPPLSGWIRDVSGSYKASFLAGGCFLVAGSLGLLLLPGYFSLQTPRPPKQNQEGSKPEDPWNPSQQNGVCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1I7</accession>
    <name>A0A670J1I7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Aminopeptidase</fullName>
            <ecNumber evidence="16">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LVRN</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_028604951.1">
        <property type="nucleotide sequence ID" value="XM_028749118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J1I7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019526.1">
        <property type="protein sequence ID" value="ENSPMRP00000018363.1"/>
        <property type="gene ID" value="ENSPMRG00000012080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606660"/>
    <dbReference type="KEGG" id="pmua:114606660"/>
    <dbReference type="CTD" id="206338"/>
    <dbReference type="GeneTree" id="ENSGT00940000160535"/>
    <dbReference type="OMA" id="RHFQMAV"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF31">
        <property type="entry name" value="AMINOPEPTIDASE Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 16" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="20">
        <location>
            <begin position="86"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="18">
        <location>
            <begin position="336"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="19">
        <location>
            <begin position="636"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="15">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="976" mass="111843" checksum="E96399615E9E9FE9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J204</accession>
    <name>A0A670J204_PODMU</name>
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        <submittedName>
            <fullName evidence="2">Small integral membrane protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SMIM31</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="68" mass="7806" checksum="47EC89E5C1F5DE6C" modified="2020-06-17" version="1">MELPFTNLEAAFILLAFVIFTLFILASIYTEPEAKDEGKYCWPFSGNRDKTCSHSHPSYIYLRGKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J292</accession>
    <name>A0A670J292_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentraxin family member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="4">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pentraxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J292"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019458.1">
        <property type="protein sequence ID" value="ENSPMRP00000018295.1"/>
        <property type="gene ID" value="ENSPMRG00000012044.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263515"/>
    <dbReference type="OMA" id="AWHYGHK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051005">
        <property type="entry name" value="Pentraxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45869">
        <property type="entry name" value="C-REACTIVE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45869:SF2">
        <property type="entry name" value="C-REACTIVE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pentraxin (PTX)" evidence="5">
        <location>
            <begin position="25"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="234" mass="26757" checksum="0496A7B8656CFDFF" modified="2020-06-17" version="1">LQHLAVLISFLLSLLLMMFSLLGLQGRVLSFLNESKESFVVISPLQPLNVMEFTLCMRVSVEDLSDRKIILFSYRSQKDELRILREAKGCFGLHMGGQSVMFALPDLSTLGSHMCVTWEAEFGLTAFWMNGKRSVRKVHNVGHIVQSGGTAMLGWDQSAQNTSEQQERRFVGEITDLYMWDYVLKSQDIQDVFQVHQFPRGNIFDWKMISYKITGNVRIWALLRYAGSSSFAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3G8</accession>
    <name>A0A670J3G8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease A-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Marsik P."/>
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                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </comment>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="SSD"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <recommendedName>
            <fullName evidence="2">B-box C-terminal domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B-box C-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="148" mass="16983" checksum="E508E6325A27D967" modified="2020-06-17" version="1">IDKQIGDALRKIITTLAVKNEEIQNFIYVLKQMLQNVEANSDRVQQDLEAEFQSLFTLLDELKDGMLMKIKQDRASRTYELQNQLAACTKALESSEELLETANQTLQGAENHDFNQVQRAARSTCLPGQWAQCPNRPALLWEFRWGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J6X6</accession>
    <name>A0A670J6X6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Family with sequence similarity 237 member B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J6X6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021176.1">
        <property type="protein sequence ID" value="ENSPMRP00000019940.1"/>
        <property type="gene ID" value="ENSPMRG00000013001.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015769"/>
    <dbReference type="OMA" id="DFMMFLK"/>
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        <property type="component" value="Chromosome 12"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN FAM237A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36690:SF1">
        <property type="entry name" value="PROTEIN FAM237B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025573001" description="Family with sequence similarity 237 member B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15622" checksum="F6C49EB9736C3B3C" modified="2020-06-17" version="1">MEFVRSRKWHLQMGCLLMVNLVYGNLEYQKEAFAGLGEIDHHCWEISSRRLVEVKKLRVSSTVTALWEFMMFLKGSSKPKHNDIFNSLAQNFWDMYVECILSSSHGMGRRQLASTENTFTYGQKASEGNFVILTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J7R2</accession>
    <name>A0A670J7R2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Unc-13 homolog B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">UNC13B</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000021781.1">
        <property type="protein sequence ID" value="ENSPMRP00000020503.1"/>
        <property type="gene ID" value="ENSPMRG00000011362.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154929"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20859">
        <property type="entry name" value="C1_Munc13-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04027">
        <property type="entry name" value="C2B_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1100:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000002">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037302">
        <property type="entry name" value="Unc-13_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF8">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="872"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="978"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="18">
        <location>
            <begin position="1408"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="19">
        <location>
            <begin position="1655"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1830"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="421"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="631"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="2002" mass="222750" checksum="742D0FE9CD41A792" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J879</accession>
    <name>A0A670J879_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LysM and putative peptidoglycan-binding domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LYSMD3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Essential for Golgi structural integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J879"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020683.1">
        <property type="protein sequence ID" value="ENSPMRP00000019482.1"/>
        <property type="gene ID" value="ENSPMRG00000012703.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158711"/>
    <dbReference type="OMA" id="IALQFCC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF5">
        <property type="entry name" value="AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="12">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="296" mass="33417" checksum="1E4EFD42E0F836A7" modified="2020-06-17" version="1">MCSFQTIIQQTPFDRMTAKKQNFSFQLPAVVQPTVDNHLYTFGNGISSDSDVLEDETELYELRPRGREKVRRSTSRERIDDIVFITKDIKEGDTLNAIALQYCCSVADIKRVNNLITDQDFFALRTIKIPVKKFSVLTETHSFPKSRQASRSASTLYSTETPDASQAAEPFSTETVGNFLKEVDRDIEQIVKCNATKRENLNEVVSALSTQQLNFEPDGKSIKRKDPHYGADWGIRWSTAVVIMVVVVIITPVFYLLYYEVLAKVDVSHHSTAEYTSVTAPSQPKPLENGINHPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8J3</accession>
    <name>A0A670J8J3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="14">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GALT</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in galactose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028604309.1">
        <property type="nucleotide sequence ID" value="XM_028748476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J8J3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022063.1">
        <property type="protein sequence ID" value="ENSPMRP00000020778.1"/>
        <property type="gene ID" value="ENSPMRG00000013488.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606342"/>
    <dbReference type="KEGG" id="pmua:114606342"/>
    <dbReference type="CTD" id="2592"/>
    <dbReference type="GeneTree" id="ENSGT00390000016188"/>
    <dbReference type="OMA" id="CFENRGA"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 14" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="15">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="16">
        <location>
            <begin position="184"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00023277"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056769"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="356" mass="41261" checksum="B622B76E3EF61BFA" modified="2020-06-17" version="1">MAEKFQPSEHQHLRYNPLRDDWVLVSAHRMRRPWQGQVEKPPQEDIPRCDPGNPLCPGAKRANGQVNPHYESTFVFDNNFPALQPDAPEPDAGDHPLFRAASARGVCKVMCFHPWSDMTLPLMSLAEIRSVIDKWSEIAVELGASYSWVQIFENKGAMMGCSNPHPHCQVWASNFLPNEASLEDRTQQKHLCERGIPMLLEYAQLEAERKERIVVENSDWVVVVPYWAVWPFQTLLLPRQRHIRRLQDLQDGERDSLASIMKRLLTKYDNLFQISFPYSMGWHGAPTGTYLDADCSHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLTPEQAAERLRNLPEEHYQLKHRETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J975</accession>
    <name>A0A670J975_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Vigilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">High density lipoprotein-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC114582756</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028559827.1">
        <property type="nucleotide sequence ID" value="XM_028703994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J975"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022101.1">
        <property type="protein sequence ID" value="ENSPMRP00000020816.1"/>
        <property type="gene ID" value="ENSPMRG00000013520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582756"/>
    <dbReference type="KEGG" id="pmua:114582756"/>
    <dbReference type="GeneTree" id="ENSGT00940000165211"/>
    <dbReference type="OMA" id="WGPNMKP"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22405">
        <property type="entry name" value="KH-I_Vigilin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22413">
        <property type="entry name" value="KH-I_Vigilin_rpt10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22414">
        <property type="entry name" value="KH-I_Vigilin_rpt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22416">
        <property type="entry name" value="KH-I_Vigilin_rpt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22417">
        <property type="entry name" value="KH-I_Vigilin_rpt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22418">
        <property type="entry name" value="KH-I_Vigilin_rpt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22406">
        <property type="entry name" value="KH-I_Vigilin_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22409">
        <property type="entry name" value="KH-I_Vigilin_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22410">
        <property type="entry name" value="KH-I_Vigilin_rpt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22411">
        <property type="entry name" value="KH-I_Vigilin_rpt8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22412">
        <property type="entry name" value="KH-I_Vigilin_rpt9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000046">
        <property type="entry name" value="High density lipoprotein binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000057">
        <property type="entry name" value="High density lipoprotein binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000061">
        <property type="entry name" value="High density lipoprotein binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000018">
        <property type="entry name" value="vigilin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000033">
        <property type="entry name" value="vigilin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000039">
        <property type="entry name" value="vigilin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF67">
        <property type="entry name" value="HIGH DENSITY LIPOPROTEIN-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0345">HDL</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="218"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="291"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="360"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="431"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="503"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="577"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="649"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="723"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="796"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="869"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="961"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="1039"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="1112"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077940"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020816.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1257" mass="140845" checksum="F1202537A3AE2466" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J9L9</accession>
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            <fullName evidence="19">Alpha-aminoadipic semialdehyde synthase, mitochondrial</fullName>
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        </recommendedName>
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            <fullName evidence="20">LKR/SDH</fullName>
        </alternativeName>
    </protein>
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        <name evidence="23" type="primary">AASS</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
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                <person name="Brejcha J."/>
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                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Bifunctional enzyme that catalyzes the first two steps in lysine degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-saccharopine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24520"/>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
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        </reaction>
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            <dbReference type="Rhea" id="RHEA:24521"/>
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    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-saccharopine + NADP(+) + H2O = L-lysine + 2-oxoglutarate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19373"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="Rhea" id="RHEA:19375"/>
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    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
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    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
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        <property type="component" value="Chromosome 10"/>
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        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
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    </dbReference>
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        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
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        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
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    <keyword evidence="8" id="KW-0521">NADP</keyword>
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    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="22">
        <location>
            <begin position="28"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="21">
        <location>
            <begin position="198"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012846"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012849"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
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            <dbReference type="ARBA" id="ARBA00051738"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00051926"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055923"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072416"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081012"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM01003"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAE8</accession>
    <name>A0A670JAE8_PODMU</name>
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        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JAE8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021423.1">
        <property type="protein sequence ID" value="ENSPMRP00000020177.1"/>
        <property type="gene ID" value="ENSPMRG00000013142.1"/>
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    <dbReference type="GeneTree" id="ENSGT01140000282496"/>
    <dbReference type="OMA" id="PVVDHFF"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:olfactory receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="194" mass="21290" checksum="1D3F7BDB49F787CF" modified="2020-06-17" version="1">MAYDRYLAISHPLLYTILMGRWRQVQLASASWAGGIIVSTTNVICALRLPYCGPNRVNHFICELPIVMKLACADIHSTEMIVFGTSAVVILTSLAVILASYGLILFSVLKMHSTTGLRKALSTCVSHLAVVTLFYSTVIAAYVKPPSVTDPDSDKKLAVFYIVVTPLLNPIIYTLRNKDIHAAAAKVLRRRGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JB53</accession>
    <name>A0A670JB53_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription factor Sp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SP2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028557744.1">
        <property type="nucleotide sequence ID" value="XM_028701911.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028701912.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000021727.1">
        <property type="protein sequence ID" value="ENSPMRP00000020452.1"/>
        <property type="gene ID" value="ENSPMRG00000013320.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00940000159590"/>
    <dbReference type="OMA" id="RRANVVM"/>
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        <property type="component" value="Chromosome 13"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22540">
        <property type="entry name" value="SP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000421">
        <property type="entry name" value="Sp2 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000455">
        <property type="entry name" value="Transcription factor Sp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR SP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="549"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="607" mass="63934" checksum="8AE4376CC2F662AC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBM3</accession>
    <name>A0A670JBM3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hes family bHLH transcription factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HES4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028596620.1">
        <property type="nucleotide sequence ID" value="XM_028740787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JBM3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022359.1">
        <property type="protein sequence ID" value="ENSPMRP00000021059.1"/>
        <property type="gene ID" value="ENSPMRG00000013690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602496"/>
    <dbReference type="KEGG" id="pmua:114602496"/>
    <dbReference type="CTD" id="57801"/>
    <dbReference type="GeneTree" id="ENSGT00940000163056"/>
    <dbReference type="OMA" id="GPCKLNP"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11459">
        <property type="entry name" value="bHLH-O_HES1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="9">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="291" mass="30617" checksum="542D5B30515AD8DA" modified="2020-06-17" version="1">MPADTMEKPTASPIAGAPASASQTPDKPKSASEHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSADPTVLGKYRAGFNECMNEVTRFLSTCEGVNTDVRGRLLGHLSTCLSQIMAMNYPAPPPPPPPPAASGQPAHLAQPLHVQLPGPAGGPGGMPVPCKLNPAETLSPKVYGGFQLVPATEGQFAFLIPNPAFPPGSGPVIPLYANANMPVSSGSSTATPSVSPVQGLTSFGGSLAPVSQAGGERSEAVWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBS4</accession>
    <name>A0A670JBS4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo-keto reductase family 7 like/pseudo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AKR7L</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JBS4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021927.1">
        <property type="protein sequence ID" value="ENSPMRP00000020647.1"/>
        <property type="gene ID" value="ENSPMRG00000013409.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158496"/>
    <dbReference type="OMA" id="NYWHGDL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="354" mass="39863" checksum="FFFE1D0ABAFD982F" modified="2020-06-17" version="1">MRLPLPRTWWRVRVQPEADRAAAAAGMSGLRGQSRGVRSVLGTMEFGRRADAATSGAMLRAFLARGHCELDTAHMYAGGESERILGACPLFPPVKVATKANPLEGNTLKADCVRSQLETSLQRLQAKSVDLFYLHMPDHKTPLEETLKACNELHREGKFKELGLSNYASWQVAEIYGICKANNWVLPTVYQGMYNATTRQVETELLPCLRHFGIRFYAYNPLAGGLLTGRYKYEDKDSNQQPASRFFGNDWAKIYRDRYWKKHHFQGVDLVEKALHEAYGSDTPSLTSAALRWIYHHSKLQADLGDAVIIGMSTIDQLQENLKCSEEGPLLPGVVEAFEKAWHLTAHDCPSYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBY3</accession>
    <name>A0A670JBY3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Leucine rich repeat transmembrane neuronal 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LRRTM4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Postsynaptic cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the LRRTM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JBY3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023320.1">
        <property type="protein sequence ID" value="ENSPMRP00000021958.1"/>
        <property type="gene ID" value="ENSPMRG00000014281.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154909"/>
    <dbReference type="OMA" id="LWYCNPN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000005">
        <property type="entry name" value="leucine-rich repeat transmembrane neuronal protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF19">
        <property type="entry name" value="LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="456"/>
        </location>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038250"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
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    </evidence>
    <sequence length="527" mass="60013" checksum="19FC2ED3C34B175D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JCC7</accession>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SMG8</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        </citation>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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            <dbReference type="RuleBase" id="RU367133"/>
        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Laterata</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29306" checksum="78DAA4DCD6A6EA7F" modified="2020-06-17" version="1">MPLKSGSNIWPAAFVNSSDEMTLYRSGLPGVANRFHLGAFPWQQGGSPPKRSALSLVMGQRQLTWELSAAQQRNSFGSCQERKIFPVFYPPDRLGNENVPIKGDPDRGPGAYNYAEKDNLLYQLARRPESTKGYTMGARTTPRFGLLSKHVTPDPTAYQSIWIRDHHRRQPTHVSFCSNMPRFSEKLLDKDFYPGPGTYDPYGMPHRHVTWPGKFGAPDWSLIPMPAKRTLRSELLSDKEFRKHRNLVAYLSIYYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JCW6</accession>
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        <recommendedName>
            <fullName evidence="8">Transcription factor IIIA</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JCW6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022265.1">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Putative zinc finger protein 143"/>
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        <property type="entry name" value="Putative zinc finger protein 143"/>
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        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000236">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="528" mass="58052" checksum="AFD8D3FF9FC122EE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JF39</accession>
    <name>A0A670JF39_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JF39"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024145.1">
        <property type="protein sequence ID" value="ENSPMRP00000022720.1"/>
        <property type="gene ID" value="ENSPMRG00000014754.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182788"/>
    <dbReference type="OMA" id="WENEILI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000024">
        <property type="entry name" value="Vomeronasal 2, receptor 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="523"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="786" mass="88106" checksum="0CCAE24FA3A00D04" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JF83</accession>
    <name>A0A670JF83_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acrosin</fullName>
            <ecNumber evidence="3">3.4.21.10</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.10" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670JF83"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023643.1">
        <property type="protein sequence ID" value="ENSPMRP00000022259.1"/>
        <property type="gene ID" value="ENSPMRG00000014471.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162777"/>
    <dbReference type="OMA" id="PDYGELH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007340">
        <property type="term" value="P:acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035821">
        <property type="term" value="P:modulation of process of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF8">
        <property type="entry name" value="ACROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="32"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="330" mass="35822" checksum="9A280259DBD6249C" modified="2020-06-17" version="1">MPCSCCLHDILLLGSYCGKRPLAPIHGGSMRIVGGVDALAGEWPWLVSVQIPSSKGTRHSCGGSVLSKRWVLTAAHCFKTKRSSLNHWRIVVGATDLSKLPDDVQIRSVHKVLLHQDYNPRTEANDIALIKLEKPVTFSDYVQPACLPPVTMGSDTSFSDCHISGWGTTSQNSERLGTSDILQEAKINILDTKKCNSSQWYNGAMSPHTICAGYEEGGIDSCQGDSGGPLMCKTSQDSPYYVIGITSWGKGCAQANNPGIYTFTKDFLEWILGEMVEAKGQKPKKKKKKKRKSPGGITLLPNRKDILMTQESATKPKVATGPLDTCHSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFD5</accession>
    <name>A0A670JFD5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor CP2-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114582692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the grh/CP2 family. CP2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028559747.1">
        <property type="nucleotide sequence ID" value="XM_028703914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JFD5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024578.1">
        <property type="protein sequence ID" value="ENSPMRP00000023141.1"/>
        <property type="gene ID" value="ENSPMRG00000015027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582692"/>
    <dbReference type="KEGG" id="pmua:114582692"/>
    <dbReference type="GeneTree" id="ENSGT00940000164844"/>
    <dbReference type="OMA" id="FMECSPW"/>
    <dbReference type="OrthoDB" id="9996779at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF12">
        <property type="entry name" value="GRH_CP2 DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="9">
        <location>
            <begin position="105"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="534" mass="60812" checksum="1714F8851B6B2EF4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFG1</accession>
    <name>A0A670JFG1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 11 open reading frame 96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C11orf96</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JFG1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024230.1">
        <property type="protein sequence ID" value="ENSPMRP00000022805.1"/>
        <property type="gene ID" value="ENSPMRG00000014805.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016821"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031521">
        <property type="entry name" value="DUF4695"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40250">
        <property type="entry name" value="CHROMOSOME 11 OPEN READING FRAME 96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40250:SF1">
        <property type="entry name" value="SI:CH1073-281M9.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15766">
        <property type="entry name" value="DUF4695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="337" mass="36485" checksum="CD7BF061F5397361" modified="2020-06-17" version="1">MIEVGLLCFPCGCFKVKKKKKVGRSHRAYSASAFPAAFAASPCKKGIASSPGTPLPQQAGATCFGASLSYLRLAFRVPSLPPRFCGGCWRGFPPLLGRAIPPRRRGRGAVGARVDVVVRRKGSGPSAFKWHCLSSEHAPVWAGEGYIYVGGERGEIQPGAEAAWRGDTSGARASFCQSLPPAGFTSAPFRLRSGRSHLLAPPPAAFPETPQGSEEAPSETQARGALRGPAELMGICSSYQAVMPHFVCIAEEFPQPTRPAKLPRGKLRRPRQSRFKTQPVTFDEIQEVEEEGKSFLQSLECLRRSTQNLSLQQREKKLSSCSRLRNSLDSSDSDSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFL7</accession>
    <name>A0A670JFL7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calpain-15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Small optic lobes homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CAPN15</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JFL7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024288.1">
        <property type="protein sequence ID" value="ENSPMRP00000022860.1"/>
        <property type="gene ID" value="ENSPMRG00000014837.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Calpain 15"/>
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        <property type="entry name" value="Zinc finger, RanBP2-type"/>
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        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
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        <property type="entry name" value="Pept_cys_AS"/>
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        <property type="entry name" value="Znf_RanBP2"/>
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        <property type="entry name" value="Znf_RanBP2_sf"/>
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        <property type="entry name" value="CALPAIN"/>
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        <property type="entry name" value="Peptidase_C2"/>
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        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="CALPAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ran binding protein zinc finger-like"/>
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        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_RANBP2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_RANBP2_2"/>
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    </dbReference>
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    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="16">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="16">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="16">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="16">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="17">
        <location>
            <begin position="456"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="168"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <position position="521"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="active site" evidence="12 13">
        <location>
            <position position="706"/>
        </location>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116215" checksum="EC1B3BEB3CE42FE6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JIV5</accession>
    <name>A0A670JIV5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MUS81</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the heterodimeric DNA structure-specific endonuclease complex MUS81-EME1. Part of the heterodimeric DNA structure-specific endonuclease complex MUS81-EME2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
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        <property type="nucleotide sequence ID" value="XM_028709731.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000024951.1">
        <property type="protein sequence ID" value="ENSPMRP00000023509.1"/>
        <property type="gene ID" value="ENSPMRG00000015240.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114586370"/>
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    <dbReference type="OMA" id="ELGDAMW"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
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        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033687">
        <property type="term" value="P:osteoblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072429">
        <property type="term" value="P:response to intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000001">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="293"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="579" mass="64725" checksum="07FEB0FF48FD0DB0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJ93</accession>
    <name>A0A670JJ93_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SEPTIN5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JJ93"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026006.1">
        <property type="protein sequence ID" value="ENSPMRP00000024511.1"/>
        <property type="gene ID" value="ENSPMRG00000015832.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159913"/>
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        <property type="component" value="Chromosome 16"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000064">
        <property type="entry name" value="Septin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="65"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="site" description="Important for dimerization" evidence="8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006698-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="393" mass="45421" checksum="6D969FFF4630A2DA" modified="2020-06-17" version="1">MPSCFIPLLSDPLLDISCRFPTCPFAEEKQRNGGNLQPSDHLDHEKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYKDRKLLNAEERISQTVEIVKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKAITDYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVEFMKALHEKVNIVPLIAKADCLIPSEIKKLKERIREEIDKFGIKVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAQCIQQMTSKLTQDNRIESPIPILPLPTPDAETEKLIKMKDEELRRMQEMLQKMKQQMQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JK06</accession>
    <name>A0A670JK06_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PRP39 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114586499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JK06"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025324.1">
        <property type="protein sequence ID" value="ENSPMRP00000023864.1"/>
        <property type="gene ID" value="ENSPMRG00000015451.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005033"/>
    <dbReference type="OMA" id="FQRACGY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        </source>
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        </source>
    </evidence>
    <sequence length="740" mass="85342" checksum="EAEEAA0A0C812DF6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="346" mass="38642" checksum="22971C14F0C370E6" modified="2020-06-17" version="1">MENFDKGNGTPITTFTLLGFGNDPKLQIPFFMVFVFIYTVTVVGNIIIITLVVSDHHLHTPMYYFLGNLSCLETCYTSTVLPRMLASFVTGDRTISVGGCFAQFFWFGTLAIAECYLLAAMSYDRYLAICKPLHYATLMDGKLCFLLSAGSWLCGITVMTIVVSLMSQLYYCGPSEIDHFFCELAPVINLSCSDTTMVALVGLIVSVIDAIPSCLLTLMSYVCIIATILRIPSSTGRKKAFSTCSSHLIVVSIFYGSLIFVYVLPKKEALWEVDKIFSVFYTVLTPLINPLIYSLRNKEVKESLRRIKSNQIKTLLAKPTGHSCTRVKSENRDKRKKRTGKRRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A670JM60_PODMU</name>
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        <recommendedName>
            <fullName evidence="5">Transmembrane protein 238</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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                <person name="Carneiro M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="InterPro" id="IPR029365">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28613">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28613:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 238-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15125">
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
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        </location>
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            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="14784" checksum="71D5AB1213E8B1AF" modified="2020-06-17" version="1">MGHARCGHCAVFLVAALVLDGAGLALVLAGAVGRPMVDGIPLEDFLVLTGSLLLALSLLCWLFWYSGNLRGVPSLLRLAAKLSERLSQRRRPAPAPCAPLGSGLPAKATRGAAAGAAAGPLELSCLRPAAPLEQGAARTQERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JN67</accession>
    <name>A0A670JN67_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain containing 142</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JN67"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026925.1">
        <property type="protein sequence ID" value="ENSPMRP00000025365.1"/>
        <property type="gene ID" value="ENSPMRG00000016418.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009871"/>
    <dbReference type="OMA" id="TWEQLQH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026700">
        <property type="entry name" value="CCDC142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055350">
        <property type="entry name" value="CCDC142_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21436">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21436:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14923">
        <property type="entry name" value="CCDC142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil protein 142 C-terminal" evidence="1">
        <location>
            <begin position="505"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="983" mass="108129" checksum="7A82338EC7CAC3B9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTA0</accession>
    <name>A0A670JTA0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal dependent decarboxylase domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PDXDC1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JTA0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027763.1">
        <property type="protein sequence ID" value="ENSPMRP00000026162.1"/>
        <property type="gene ID" value="ENSPMRG00000016790.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009628"/>
    <dbReference type="OMA" id="RIFSEWC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000036">
        <property type="entry name" value="pyridoxal-dependent decarboxylase domain-containing protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF1">
        <property type="entry name" value="PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="492" mass="55044" checksum="CE32D81B98E13F83" modified="2020-06-17" version="1">MVDPTLAEMGKNLNEAMKMLEDNQRKVEEENEKKYTRKDIPGPLQGSGQDMVSILQLVQNLMHGDEEEESLQSYRLQNVGEQGHMALLGHSLAAYISVLDRERLRKLTSRILSDTTLWLCRLFRFENGSAYYHEDDREGLLKVCRLVIHSRYEDYTTEGFNVLYNKQPVIYISSAARAGLGQALCNQLGLPLSCMCRVPCNTMFGSQHQMDVALLDKLIKEDIDSGKLPILLVANAGTPGAGHTDKLGRLKELCEQHGMWLHVEGVNLATLALGYVSSSVLAATKCDSMTLTLGPWLGLPAVPAVTLYRHEDPSLSLVAGLTSSQAVEKLRALPLWLSLQYLGHDGIVERIKHSSQLVRSLALLWLLCISMDELAFHVLLEEVFYRLRIIVCQPSGGESVKQLTHLVTSSERRWPLPSCAWGLGLLIMGLHAAVSHRCAFSQGTSCHKRCQEVGLTSAGFFPFSCCYFLYCFKRPLSCCIMYSTFEMWVDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTN4</accession>
    <name>A0A670JTN4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">UNC homeobox</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">UNCX</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the paired homeobox family. Unc-4 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028562419.1">
        <property type="nucleotide sequence ID" value="XM_028706586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JTN4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030225.1">
        <property type="protein sequence ID" value="ENSPMRP00000028493.1"/>
        <property type="gene ID" value="ENSPMRG00000018402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584597"/>
    <dbReference type="KEGG" id="pmua:114584597"/>
    <dbReference type="CTD" id="340260"/>
    <dbReference type="GeneTree" id="ENSGT00940000161420"/>
    <dbReference type="OMA" id="HAQFGGL"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001502">
        <property type="term" value="P:cartilage condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035726">
        <property type="term" value="P:common myeloid progenitor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021516">
        <property type="term" value="P:dorsal spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021889">
        <property type="term" value="P:olfactory bulb interneuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000057">
        <property type="entry name" value="Short stature homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="155"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="380"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
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        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="519" mass="53929" checksum="07C3266CCACBAC3C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTR6</accession>
    <name>A0A670JTR6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="7">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MSRB3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:21260"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58773"/>
            <dbReference type="EC" id="1.8.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028601367.1">
        <property type="nucleotide sequence ID" value="XM_028745534.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028601368.1">
        <property type="nucleotide sequence ID" value="XM_028745535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JTR6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028912.1">
        <property type="protein sequence ID" value="ENSPMRP00000027255.1"/>
        <property type="gene ID" value="ENSPMRG00000017578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604931"/>
    <dbReference type="CTD" id="253827"/>
    <dbReference type="GeneTree" id="ENSGT00940000155240"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF56">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SelR"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
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            <end position="184"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049261"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="184" mass="20376" checksum="1A2702F58D4EC87B" modified="2020-06-17" version="1">MSAFNLLHLVTKSQPVALRACGLPSGSRRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKAHGIYKCVVCGTPLFKSETKFDSNSGWPSFYDVMASDRITFTDDYSYGMHRVETSCSQCGAHLGHIFDDGPRPSGKRYCINSASLSFESADKNHAGEGSISATSAQPDKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTU9</accession>
    <name>A0A670JTU9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JTU9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028950.1">
        <property type="protein sequence ID" value="ENSPMRP00000027290.1"/>
        <property type="gene ID" value="ENSPMRG00000017604.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162068"/>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="DUF4371"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF14">
        <property type="entry name" value="TTF-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTF-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="735" mass="84786" checksum="E4E92AF063AA043E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JX03</accession>
    <name>A0A670JX03_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RLIM</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNF12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670JX03"/>
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        <property type="protein sequence ID" value="ENSPMRP00000029823.1"/>
        <property type="gene ID" value="ENSPMRG00000019294.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155753"/>
    <dbReference type="OMA" id="YEGGHEG"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060816">
        <property type="term" value="P:random inactivation of X chromosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16674">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000054">
        <property type="entry name" value="E3 ubiquitin-protein ligase RLIM isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058896">
        <property type="entry name" value="RNF6/12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25914">
        <property type="entry name" value="RNF6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="546"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="106"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="625" mass="69202" checksum="39765FD6B4BD81A3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXT0</accession>
    <name>A0A670JXT0_PODMU</name>
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        <recommendedName>
            <fullName evidence="4">Calcineurin-binding protein cabin-1 MEF2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Chromosome 16"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0031491">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13839">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015134">
        <property type="entry name" value="MEF2-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09047">
        <property type="entry name" value="MEF2_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="620" mass="66749" checksum="F2DED425E4066282" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZI4</accession>
    <name>A0A670JZI4_PODMU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the SH3BGR family.</text>
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        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="193" mass="21226" checksum="23F531A824EA8674" modified="2020-06-17" version="1">MGQGDKIQAAQEMLRFHSNCEDCGSGGRAVGRVLSRTEQIKLKWAEEVDERGSGPSAGVSMGTIRVYYTSVTGSREVKQRQSDVIRILDGNRMKYQLVDVSISESLLQEMRDKAGKPDAIPPQIFNGEEYCGVLKGLDNCPLGQEAQHLILAEDTDVPPHCPTDTLEDANKRKYECTGSCKQGDVTCTVKEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0B4</accession>
    <name>A0A670K0B4_PODMU</name>
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        <submittedName>
            <fullName evidence="2">Serine rich and transmembrane domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SERTM2</name>
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    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
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            <taxon>Lacertidae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="entry name" value="SRTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="91" mass="10238" checksum="212E721C187C61BD" modified="2020-06-17" version="1">TEVYFRFRGNLTGRAHPPPTLATGVANADKYSNLYMYVGLFLTLLAILLILLFTMLLRLKHVISPITTSPESTENIQQFTDVEMHGRIPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2P6</accession>
    <name>A0A670K2P6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K2P6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019836.1">
        <property type="protein sequence ID" value="ENSPMRP00000018670.1"/>
        <property type="gene ID" value="ENSPMRG00000012248.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000031010.1">
        <property type="protein sequence ID" value="ENSPMRP00000029237.1"/>
        <property type="gene ID" value="ENSPMRG00000018897.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000029384.1"/>
        <property type="gene ID" value="ENSPMRG00000018994.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000031629.1">
        <property type="protein sequence ID" value="ENSPMRP00000029821.1"/>
        <property type="gene ID" value="ENSPMRG00000019292.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000034470.1">
        <property type="protein sequence ID" value="ENSPMRP00000032507.1"/>
        <property type="gene ID" value="ENSPMRG00000021063.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000036059.1">
        <property type="protein sequence ID" value="ENSPMRP00000033998.1"/>
        <property type="gene ID" value="ENSPMRG00000022057.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000036593.1">
        <property type="protein sequence ID" value="ENSPMRP00000034496.1"/>
        <property type="gene ID" value="ENSPMRG00000022386.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="145" mass="15789" checksum="7368BD9149A7941F" modified="2020-06-17" version="1">MSYVFVNDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIPAARGNVDICQLLHKFGADLLATDYQGNTALHLCGHVDTIQFLVSNGLKIDICLFCSLAGVEIQHSSGLMSCTKNKSCFRADTGETGKAFRSIIITYNGFAFPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3E5</accession>
    <name>A0A670K3E5_PODMU</name>
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        <submittedName>
            <fullName evidence="5">V-set and immunoglobulin domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">VSIG4</name>
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    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of complement activation, alternative pathway"/>
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    </dbReference>
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        <property type="term" value="P:negative regulation of interleukin-2 production"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_V-set"/>
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    <dbReference type="PANTHER" id="PTHR15466">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN CONTAINING 4"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15466:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025662315" evidence="3">
        <location>
            <begin position="19"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="144"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="415" mass="45571" checksum="1D8D0542711E5B92" modified="2020-06-17" version="1">MAKVAWLWFLLLAPNIHGKVVLDLTGPHETHGTWRASVTLPCLYDPSPDFLEQSVVWRQRDHHNRAIFHRDNESGDQTPVAHFRDRLTVPKQPLGDVSLLIHDLDMADRGRYACEVTFLTKNNTRVTISRIIILKVKKVPVAKPVIKATNNDETSLPGVMRFNLSCLTSGSPPITYRWFKQVEGSNATLVGKEAVLTFDRLEASDAGRYYCEVENRVSKQIQQSRAIRINVQSSAVPSTMGPSTEFAMSTTAVAGATSTTWMAFGGRTTSGSFNSRELTMAKRPATTPATTTASTTGKPLPKPTGSKMSTFAIIMLVLLSLVLTGILTCIVCYRIHGTGDGFPISYFCITRGTDEDNDDDNTGGSDGDNPHDLGRNDSGQKDSCGEPASRTQAQEHFALLCFPEADLHKHFCLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3V0</accession>
    <name>A0A670K3V0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glutamate pyruvate transaminase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glutamic--alanine transaminase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamic--pyruvic transaminase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GPT2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028596068.1">
        <property type="nucleotide sequence ID" value="XM_028740235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K3V0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032142.1">
        <property type="protein sequence ID" value="ENSPMRP00000030314.1"/>
        <property type="gene ID" value="ENSPMRG00000019601.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602250"/>
    <dbReference type="KEGG" id="pmua:114602250"/>
    <dbReference type="CTD" id="84706"/>
    <dbReference type="GeneTree" id="ENSGT00940000159061"/>
    <dbReference type="OMA" id="FGFECPP"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000226">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000345">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF311">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="137"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="548" mass="60842" checksum="D53E3C5924488B32" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7N9</accession>
    <name>A0A670K7N9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase I subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">POLR1E</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7N9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034780.1">
        <property type="protein sequence ID" value="ENSPMRP00000032801.1"/>
        <property type="gene ID" value="ENSPMRG00000021257.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018004"/>
    <dbReference type="OMA" id="DVYPFDE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001188">
        <property type="term" value="P:RNA polymerase I preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="392" mass="44405" checksum="AB79289CAC878A4D" modified="2020-06-17" version="1">MAAEARWCYRGDPQEEQRAPLVQFTNGKLKSSENMNFTLYRNKDTSNPKKKNKRMLNAETERLSYVGNNFSTGAMKSRTPCRYFVGVLDKNSGQMEVYNAELFNMQPLISDGVADDDLSEYLTKSYREKIDMCIEAFGTNKQRRALNSRRMNEVGKEVLNKAVTKAAEDIIETKGVAALVSDAAEGDKADVSLVLPPCHEDAGRPEDVYKFEDIIPPAEYEALQAPAAAFMNVTPEEIIKMTEEKRYCSFVLDELKAMPLDEKKRDHKARCLSFWIVLNVRFPSLVYTALIHPLLFWCLRLQNQVSASMKVKITAYAIALALHINNFQTDLTVLQRDLKMRDSRILDIAKAMRLKISKSKSLSGLDEHKLGTLSLPLPVYKMPSGGRKRKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBZ2</accession>
    <name>A0A670KBZ2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Nitric oxide synthase 1</fullName>
            <ecNumber evidence="8">1.14.13.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Constitutive NOS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">NC-NOS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">NOS type I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Neuronal NOS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Nitric oxide synthase, brain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Peptidyl-cysteine S-nitrosylase NOS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="primary">NOS1</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="37" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:19897"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:19898"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <location evidence="5">Sarcolemma</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036430.1">
        <property type="protein sequence ID" value="ENSPMRP00000034336.1"/>
        <property type="gene ID" value="ENSPMRG00000022223.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159357"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044305">
        <property type="term" value="C:calyx of Held"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035605">
        <property type="term" value="F:peptidyl-cysteine S-nitrosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033555">
        <property type="term" value="P:multicellular organismal response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051926">
        <property type="term" value="P:negative regulation of calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043267">
        <property type="term" value="P:negative regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051612">
        <property type="term" value="P:negative regulation of serotonin uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106071">
        <property type="term" value="P:positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098735">
        <property type="term" value="P:positive regulation of the force of heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060078">
        <property type="term" value="P:regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099163">
        <property type="term" value="P:synaptic signaling by nitric oxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042311">
        <property type="term" value="P:vasodilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042178">
        <property type="term" value="P:xenobiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06202">
        <property type="entry name" value="Nitric_oxide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00795">
        <property type="entry name" value="NOS_oxygenase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06708">
        <property type="entry name" value="PDZ_nNOS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.440.10:FF:000001">
        <property type="entry name" value="Endothelial nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000002">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000069">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000003">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000003">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1230.10:FF:000001">
        <property type="entry name" value="Nitric oxide synthase, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012144">
        <property type="entry name" value="NOS_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF2">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
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            <end position="959"/>
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            <begin position="1014"/>
            <end position="1261"/>
        </location>
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            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
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            <begin position="296"/>
            <end position="309"/>
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    </feature>
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        <location>
            <position position="430"/>
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        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
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            <dbReference type="ARBA" id="ARBA00004468"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022630"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    <evidence type="ECO:0000256" key="18">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="24">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029891"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00032538"/>
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    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00035211"/>
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    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00035474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR000333-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034336.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1449" mass="163060" checksum="3A0F101D17F6F5C3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCS8</accession>
    <name>A0A670KCS8_PODMU</name>
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        <submittedName>
            <fullName evidence="15">KLF transcription factor 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KLF13</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
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        <property type="nucleotide sequence ID" value="XM_028706250.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000033394.1"/>
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        <property type="component" value="Chromosome 14"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of erythrocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Krueppel-like factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Krueppel-like factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 13"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="76"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="276" mass="30280" checksum="BC4A0DE4A3FD8F47" modified="2020-06-17" version="1">MATAAYFAAECLVSMSSRAVIHSPMREPAPQPVGRAAPRIISNRAEKPEVKEVGRDNGGGSSVYAVASILADLNQHVPPKLSSPQGENLESVDRGGASLSHKEFGEESVLLAGKRGGGRATTPTSLGAPSQPSPRQRSRRGRCRTEPELPQKKHKCHYAGCEKVYGKSSHLKAHLRTHTGERPFECRWEDCNKKFARSDELARHFRTHTGEKKFGCPLCEKRFMRSDHLTKHARRHSNFHPSMLKRRSGSSSRTGSVSDYSRSDASSPTISPSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDK9</accession>
    <name>A0A670KDK9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketimine reductase mu-crystallin</fullName>
            <ecNumber evidence="21">1.5.1.1</ecNumber>
            <ecNumber evidence="3">1.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NADP-regulated thyroid-hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CRYM</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58517"/>
            <dbReference type="ChEBI" id="CHEBI:176873"/>
            <dbReference type="EC" id="1.5.1.25"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:12506"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12500"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58517"/>
            <dbReference type="ChEBI" id="CHEBI:176873"/>
            <dbReference type="EC" id="1.5.1.25"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:12502"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-lanthionine ketimine + NADPH + 2 H(+) = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68040"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176891"/>
            <dbReference type="ChEBI" id="CHEBI:176892"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:68041"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-cystathionine ketimine + NADH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:68032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:176808"/>
            <dbReference type="ChEBI" id="CHEBI:176810"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:68033"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-cystathionine ketimine + NADPH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68036"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176808"/>
            <dbReference type="ChEBI" id="CHEBI:176810"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:68037"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Delta(2)-thiazoline-2-carboxylate + NADPH + 2 H(+) = L-thiazolidine-2-carboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176895"/>
            <dbReference type="ChEBI" id="CHEBI:176896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:68073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61185"/>
            <dbReference type="ChEBI" id="CHEBI:77631"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:30809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12524"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61185"/>
            <dbReference type="ChEBI" id="CHEBI:77631"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:12526"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-proline + NAD(+) = 1-pyrroline-2-carboxylate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:20323"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:20319"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer. Binds the thyroid hormone triiodothyronine (T3); T3 binding inhibits enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.1" evidence="21"/>
    <dbReference type="EC" id="1.5.1.25" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028562315.1">
        <property type="nucleotide sequence ID" value="XM_028706482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KDK9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036557.1">
        <property type="protein sequence ID" value="ENSPMRP00000034460.1"/>
        <property type="gene ID" value="ENSPMRG00000022368.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584538"/>
    <dbReference type="KEGG" id="pmua:114584538"/>
    <dbReference type="CTD" id="1428"/>
    <dbReference type="GeneTree" id="ENSGT00390000000237"/>
    <dbReference type="OMA" id="VKIVNVH"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047125">
        <property type="term" value="F:delta1-piperideine-2-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050241">
        <property type="term" value="F:pyrroline-2-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047127">
        <property type="term" value="F:thiomorpholine-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070324">
        <property type="term" value="F:thyroid hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042403">
        <property type="term" value="P:thyroid hormone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070327">
        <property type="term" value="P:thyroid hormone transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1780.10:FF:000001">
        <property type="entry name" value="Ketimine reductase mu-crystallin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000241">
        <property type="entry name" value="ketimine reductase mu-crystallin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00093273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00093567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00093598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="316" mass="33884" checksum="F6F4C3BCDF0FF6B1" modified="2020-06-17" version="1">MSHAVPPPVFLAAGEVEKHFPAASRLISALATALANFSSGAEGGVVQPVRTVVPIQKYSGFLGIMPAYSEKDDALTTKLVTFYEHVTDPAVPSHQATVLLFEPSNGTLKAVMDGSIITAKRTAAVSAIATKYLMPVDSEVLCILGAGVQAYSHYEIFTEMFSFKEVKIWNRTKEKAEKFARSVHGPVQVCSSAQEAVTGADVIITVTMATKPILHGEWVKPGAHINAVGASRPDWRELDDDAMRNSVLYVDSREAAIRESGDVILSGAEIFAELGEVVLGTKPALREETTVFKSLGMAIEDTVPAKMIFDSWSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGR0</accession>
    <name>A0A670KGR0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">KLF transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KLF2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KGR0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038772.1">
        <property type="protein sequence ID" value="ENSPMRP00000036603.1"/>
        <property type="gene ID" value="ENSPMRG00000023600.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163163"/>
    <dbReference type="OMA" id="ICEECKM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071499">
        <property type="term" value="P:cellular response to laminar fluid shear stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097533">
        <property type="term" value="P:cellular stress response to acid chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043249">
        <property type="term" value="P:erythrocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903671">
        <property type="term" value="P:negative regulation of sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045429">
        <property type="term" value="P:positive regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051247">
        <property type="term" value="P:positive regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048386">
        <property type="term" value="P:positive regulation of retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042311">
        <property type="term" value="P:vasodilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000237">
        <property type="entry name" value="Krueppel-like factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000707">
        <property type="entry name" value="Putative Krueppel-like factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF149">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="111" mass="12850" checksum="0340EEA82254AA38" modified="2020-06-17" version="1">GPSAACLPGTPKPKRGRRSWPRKRTATHTCTYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKZ6</accession>
    <name>A0A670KKZ6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KKZ6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039204.1">
        <property type="protein sequence ID" value="ENSPMRP00000037020.1"/>
        <property type="gene ID" value="ENSPMRG00000023837.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182870"/>
    <dbReference type="OMA" id="LGSSWHY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09925">
        <property type="entry name" value="SH2_SHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000005">
        <property type="entry name" value="SHC-transforming protein 1 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051235">
        <property type="entry name" value="CEP152/SHC-Transforming"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035676">
        <property type="entry name" value="SHC_SH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337">
        <property type="entry name" value="SHC TRANSFORMING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337:SF12">
        <property type="entry name" value="SHC-TRANSFORMING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="218" mass="24166" checksum="83DC2DF604698CF9" modified="2020-06-17" version="1">MINFCFFQTGSPKSTNIYENCPEENKAVDGCTEQGQGGKKDASLLKNASKMDLFDDPRYINTQNLQTTPSNTRSCTSEQTCGSPVHHSKSLEEVEQNPASLGSIAGIQHHLWNEECYHGKLTRKAAESLLVNDGDFLVRESTTSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDSVDHLIRYHMENKLPIISSGSELNLKQPLRKGIGHPQYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KPP3</accession>
    <name>A0A670KPP3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Cell membrane</location>
            <topology evidence="1 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KPP3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039292.1">
        <property type="protein sequence ID" value="ENSPMRP00000037107.1"/>
        <property type="gene ID" value="ENSPMRG00000023884.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160476"/>
    <dbReference type="OMA" id="ECLAPIM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000106">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000004">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF15">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 20" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 20" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="19" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="837"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="977"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112196" checksum="F756FAC3B7ACAE4F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMB1</accession>
    <name>A0A670HMB1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 24 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC24A4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HMB1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000122.1">
        <property type="protein sequence ID" value="ENSPMRP00000000116.1"/>
        <property type="gene ID" value="ENSPMRG00000000074.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234532"/>
    <dbReference type="OMA" id="LFGSWGH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120199">
        <property type="term" value="C:cone photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097186">
        <property type="term" value="P:amelogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990034">
        <property type="term" value="P:calcium ion export across plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071486">
        <property type="term" value="P:cellular response to high light intensity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036368">
        <property type="term" value="P:cone photoresponse recovery"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050911">
        <property type="term" value="P:detection of chemical stimulus involved in sensory perception of smell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042756">
        <property type="term" value="P:drinking behavior"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086009">
        <property type="term" value="P:membrane repolarization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050849">
        <property type="term" value="P:negative regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021630">
        <property type="term" value="P:olfactory nerve maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903998">
        <property type="term" value="P:regulation of eating behavior"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990680">
        <property type="term" value="P:response to melanocyte-stimulating hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990834">
        <property type="term" value="P:response to odorant"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000037">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000005">
        <property type="entry name" value="sodium/potassium/calcium exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF21">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="62"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="314"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="480" mass="53791" checksum="8779FFD693DD7058" modified="2020-06-17" version="1">VVWHYSGTLGYIRFRLQTLLTQKYYLRLRILLQGENRNPIHEFPDDLFTNKERQQGAVLLHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWSVFRDSVYYTISVIVLIAGTQQYGRNSVVMVDEIICSSPPKYRFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLIHAANGKLIQNGKHENIENGAIHVDNQEEEHEHINLSPFSPPEGKMDKVKWILTWPLIILLFFTIPNCSKPRWENFFMLTFLLSTLWIAVFSYFMVWLVTVIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSFINSKGLVYSVVLLLGSVALTVGGIHINKWKLDKKLGIYVLVLYAVFLCFSILIEFNVFTFVNFPMCREDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP43</accession>
    <name>A0A670HP43_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HP43"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000850.1">
        <property type="protein sequence ID" value="ENSPMRP00000000802.1"/>
        <property type="gene ID" value="ENSPMRG00000000588.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153582"/>
    <dbReference type="OMA" id="SWNTMEA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001857">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <begin position="57"/>
            <end position="66"/>
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            <begin position="70"/>
            <end position="84"/>
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        <location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="346" mass="40087" checksum="F4B1D0A55240F0DC" modified="2020-06-17" version="1">MVRQKPIFQATAPSEATAQRDMDAGVLQWRQNKRKTLKTAQDEMVEQNLLSHDGPRREKRSHRKQKTDKSIVSQSSFFTEQGEQPENRDALRTSTKEKTIQRAESGEISSGSRNNGYSPTCPTEVKQYGKSFRNQKQFAAHQKIHTGQKSHKCADCGKSFRRKWTLTIHKRTHTGEKPYKCLECDKSFNYISHLTRHQRIHTGEKPFKCLACEKSFTVSSSLTKHQRTHTKEKPYKCLVCDKSFTDSSNLTVHKRTHTGEKPYKCSVCGKHFTQIANLKVHERTHTGEKLYKCEQCGKSFTRKADLQRHQKHHTRETPNQDSNLSERLDDESRPHEGENAQRMETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP70</accession>
    <name>A0A670HP70_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Distal-less homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DLX1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the distal-less homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605521.1">
        <property type="nucleotide sequence ID" value="XM_028749688.1"/>
    </dbReference>
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        <property type="gene ID" value="ENSPMRG00000001095.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00940000160029"/>
    <dbReference type="OMA" id="GPPVWNT"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Distal-less homeobox 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
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        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF33">
        <property type="entry name" value="HOMEOBOX PROTEIN DLX-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
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        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="255" mass="27761" checksum="0CE5FB4449F981F6" modified="2020-06-17" version="1">MTMTTMPESLNSPVSGKAVFMEFGPPGQQMPPSPMSHGHYSMHCLHSAGHSQPDSSYSAASSFSRPLGYPYVNSVSSHAANPYMSSVQSYPNSTSLAQTRLEETGAETEKSTVVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLMKQGGAALESSALANGRSLSASSPPVPPVWNTTSTSGKTSTGTPATYIPSYTSWYPSAHQETMQQPQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQ89</accession>
    <name>A0A670HQ89_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HQ89"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001812.1">
        <property type="protein sequence ID" value="ENSPMRP00000001706.1"/>
        <property type="gene ID" value="ENSPMRG00000001253.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="61" mass="6857" checksum="79B4DFE7DE84E265" modified="2020-06-17" version="1">DTTFSYLDLFQFDVAVLFTEGELALLDPDQRSLNQGVMEEIYGTAASQGKQATRLDQSTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRC5</accession>
    <name>A0A670HRC5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear factor, erythroid 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NFE2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. CNC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028564870.1">
        <property type="nucleotide sequence ID" value="XM_028709037.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028564877.1">
        <property type="nucleotide sequence ID" value="XM_028709044.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028564888.1">
        <property type="nucleotide sequence ID" value="XM_028709055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HRC5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002236.1">
        <property type="protein sequence ID" value="ENSPMRP00000002101.1"/>
        <property type="gene ID" value="ENSPMRG00000001541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586091"/>
    <dbReference type="KEGG" id="pmua:114586091"/>
    <dbReference type="CTD" id="4778"/>
    <dbReference type="GeneTree" id="ENSGT00950000182892"/>
    <dbReference type="OMA" id="YCDIFQH"/>
    <dbReference type="OrthoDB" id="7458135at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14720">
        <property type="entry name" value="bZIP_NFE2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-E2 45 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="313"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="421" mass="46431" checksum="7E0979E1424D8EA1" modified="2020-06-17" version="1">MSNPGSCTLQIHRASSENFAATANFGGTQLEQRLGRARPDKMPPFPPQQGWARGTFLPLHNPLAGGELGPQGEMELTWQEILSISELQGLEMPAESCYDPALCSHAQPMVPPPSYGPCTEMGDCSISYSHPAPAYERPFPETLPGPCTVYSYTGMLISSSLEPPGPAILGECKGAPGMVLERDLASCYGPQGPCKPQEDLESDSGLSLNYSDAESLEAEGLERAEYAPLYPMDHAPPYPMLPPVPELPCANPPLEHSLEKGRSPRGELVGSRDERRALAMNIPFPVEKIINLPVDDFNELVTRFPLSEPQLALIRDIRRRGKNKVAAQNCRKRKLETLVHLERELEELSCERQRLLQDRGEFNRTLALTKQKLGALYHQVFCMLRDEAGNTYSPEEYVLQLAADGGVFLVPRNNQPDNPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRP8</accession>
    <name>A0A670HRP8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 91-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114595518</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HRP8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002369.1">
        <property type="protein sequence ID" value="ENSPMRP00000002226.1"/>
        <property type="gene ID" value="ENSPMRG00000001620.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="OMA" id="KSHIGPR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000514">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000027">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
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</entry>
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        <scope>IDENTIFICATION</scope>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
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    </comment>
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            <name>heme b</name>
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            <begin position="48"/>
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        <source>
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    <sequence length="278" mass="31328" checksum="4380ACD6419719E5" modified="2020-06-17" version="1">MSRDDGAEGDLELWNYFSRRSPRLRRKRGVLPVNRMIPRVSFLLLSILLGILGILCVVFTVYWTQHWLGGFAWDGSSQMFNWHPVFMVTGMLVLTGAAVLVYRVPLSWSGPKLPWKLLHAGLTLAAFILIVLGLVAVFEYHNKQGIANMYSLHSWLGLAAVLLFSCQWAMGFASFLLPWAPTWFRALYKPIHVFFGSAIIPLVVAACISGINEKLFFKLTNTSTPYAQLPAEAWFANILGMLILVFGLLVLFALAMPVWKRPDVNSQDTQEPLLQEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        </source>
    </evidence>
    <sequence length="1244" mass="146805" checksum="5BDEBA228CFEBE66" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HVH6</accession>
    <name>A0A670HVH6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SNW domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SNW1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
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                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Pauperio F."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SNW family.</text>
    </comment>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:enzyme binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:Notch binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042974">
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:nuclear vitamin D receptor binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:SMAD binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:transcription coactivator activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cellular response to retinoic acid"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:host-mediated activation of viral transcription"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030511">
        <property type="term" value="P:positive regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070564">
        <property type="term" value="P:positive regulation of vitamin D receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048385">
        <property type="term" value="P:regulation of retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048384">
        <property type="term" value="P:retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="4">
        <location>
            <begin position="180"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="541" mass="62066" checksum="C3761A401FEC8491" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWN4</accession>
    <name>A0A670HWN4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proliferation-associated protein 2G4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PA2G4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HWN4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004230.1">
        <property type="protein sequence ID" value="ENSPMRP00000003961.1"/>
        <property type="gene ID" value="ENSPMRG00000002714.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154281"/>
    <dbReference type="OMA" id="SRMFYSE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000008">
        <property type="entry name" value="Proliferation-associated 2G4, b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000031">
        <property type="entry name" value="Proliferation-associated 2G4-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Peptidase M24" evidence="18">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="397" mass="44388" checksum="57827B65E0D95CE1" modified="2020-06-17" version="1">MSGEEEAAELTIAEDVVVNKYKMGGEIANRVLRTVVEAAKSGVSVLSLCERGDAMIMEETGKIFKKEKDMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKDGDLVKIDLGVHVDGFIANVAHSFVIDASKETPVSGRKADVIKAAHLCAEAALRLVKPGNQNSQVTDAWNKISHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPSDQQRKDHEKAEFEVHEVYAIDVLISTGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYDKEGEFVAQFKFTVLLMPNGPMRITSGPFEPELYKSEFEVQDADLKALLQSSASRKAQKKKKKKVLGCVCVLISLHFFKYCNLLLDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HYK9</accession>
    <name>A0A670HYK9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 25">Glycerol-3-phosphate acyltransferase 1, mitochondrial</fullName>
            <ecNumber evidence="5 25">2.3.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">GPAM</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids. Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid. Has a narrow hydrophobic binding cleft that selects for a linear acyl chain. Catalytic activity is higher for substrates with a 16-carbon acyl chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:74547"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:37204"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA</text>
            <dbReference type="Rhea" id="RHEA:33203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:64840"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:33204"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:35727"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:72682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:35728"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37199"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:37200"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:15325"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="2.3.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>sn-glycerol 3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:35723"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:35724"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>sn-glycerol 3-phosphate + octadecanoyl-CoA = 1-octadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37195"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:74565"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:37196"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 25">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.15" evidence="5 25"/>
    <dbReference type="RefSeq" id="XP_028586118.1">
        <property type="nucleotide sequence ID" value="XM_028730285.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586119.1">
        <property type="nucleotide sequence ID" value="XM_028730286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HYK9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004508.1">
        <property type="protein sequence ID" value="ENSPMRP00000004222.1"/>
        <property type="gene ID" value="ENSPMRG00000002856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597482"/>
    <dbReference type="KEGG" id="pmua:114597482"/>
    <dbReference type="CTD" id="57678"/>
    <dbReference type="GeneTree" id="ENSGT00520000055570"/>
    <dbReference type="OMA" id="RCKHTNE"/>
    <dbReference type="OrthoDB" id="5962536at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050798">
        <property type="term" value="P:activated T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006924">
        <property type="term" value="P:activation-induced cell death of T cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055089">
        <property type="term" value="P:fatty acid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070236">
        <property type="term" value="P:negative regulation of activation-induced cell death of T cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042104">
        <property type="term" value="P:positive regulation of activated T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028354">
        <property type="entry name" value="GPAT_PlsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF16">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500064">
        <property type="entry name" value="GPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000437">
        <property type="entry name" value="GPAT_DHAPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="17 25" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 25" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 25" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 25" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15 25" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 25" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 25" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="26">
        <location>
            <begin position="225"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRNR" id="PIRNR000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="831" mass="94259" checksum="1407419C5D588D16" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0X3</accession>
    <name>A0A670I0X3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein RRP5 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Programmed cell death protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PDCD11</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with NF-kappa-B p50/NFKB1 and NF-kappa-B p65/RELA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028586217.1">
        <property type="nucleotide sequence ID" value="XM_028730384.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586218.1">
        <property type="nucleotide sequence ID" value="XM_028730385.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000005930.1">
        <property type="protein sequence ID" value="ENSPMRP00000005573.1"/>
        <property type="gene ID" value="ENSPMRG00000003794.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597519"/>
    <dbReference type="CTD" id="22984"/>
    <dbReference type="GeneTree" id="ENSGT00390000012228"/>
    <dbReference type="OMA" id="GQYLRAY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:rRNA processing"/>
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    </dbReference>
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        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
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        <property type="entry name" value="S1_Rrp5_repeat_hs13"/>
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        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
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        <property type="entry name" value="S1_Rrp5_repeat_hs2_sc2"/>
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        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
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        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
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        <property type="entry name" value="Programmed cell death 11"/>
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        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="9"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="HAT"/>
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        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
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    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
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    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
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    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
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    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
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    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
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    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="9"/>
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        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="S1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="84"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="188"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="282"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="366"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="454"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="543"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="731"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="1030"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="1144"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="1225"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="14">
        <location>
            <begin position="1319"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1396"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1495"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1409"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1501"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1815" mass="202200" checksum="06D3066D311B6E86" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1M5</accession>
    <name>A0A670I1M5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aminopeptidase B</fullName>
            <ecNumber evidence="12">3.4.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Arginine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RNPEP</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys.</text>
            <dbReference type="EC" id="3.4.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.6" evidence="12"/>
    <dbReference type="RefSeq" id="XP_028590490.1">
        <property type="nucleotide sequence ID" value="XM_028734657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I1M5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005727.1">
        <property type="protein sequence ID" value="ENSPMRP00000005375.1"/>
        <property type="gene ID" value="ENSPMRG00000003674.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599423"/>
    <dbReference type="KEGG" id="pmua:114599423"/>
    <dbReference type="CTD" id="6051"/>
    <dbReference type="GeneTree" id="ENSGT00940000160431"/>
    <dbReference type="OMA" id="QLMDLDD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000011">
        <property type="entry name" value="Arginyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF1">
        <property type="entry name" value="AMINOPEPTIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="19">
        <location>
            <begin position="483"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="279"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="583"/>
            <end position="585"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="632" mass="70094" checksum="77CE5A64ECCEB786" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I2U4</accession>
    <name>A0A670I2U4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Histone-lysine N-methyltransferase NSD2</fullName>
            <ecNumber evidence="23">2.1.1.357</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">H3-K36-HMTase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Multiple myeloma SET domain-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Nuclear SET domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Nuclear receptor-binding SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="39" type="primary">NSD2</name>
    </gene>
    <organism evidence="39 40">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="39 40" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="39" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="39" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60308"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.357"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9786"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with HDAC1. Interacts (via PHD-type zinc fingers 1, 2 and 3) with SALL1. Interacts (via PHD-type 1, 2 and 3) with SALL4. Interacts with NANOG. Interacts with OGT. Interacts (via HMG box) with NKX2-5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.357" evidence="23"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006107.1">
        <property type="protein sequence ID" value="ENSPMRP00000005742.1"/>
        <property type="gene ID" value="ENSPMRG00000003856.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157429"/>
    <dbReference type="OMA" id="CQEHEEL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140954">
        <property type="term" value="F:histone H3K36 dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003289">
        <property type="term" value="P:atrial septum primum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003290">
        <property type="term" value="P:atrial septum secundum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003149">
        <property type="term" value="P:membranous septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048298">
        <property type="term" value="P:positive regulation of isotype switching to IgA isotypes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001032">
        <property type="term" value="P:regulation of double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070201">
        <property type="term" value="P:regulation of establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21991">
        <property type="entry name" value="HMG-box_NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15654">
        <property type="entry name" value="PHD3_NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15660">
        <property type="entry name" value="PHD5_NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20162">
        <property type="entry name" value="PWWP_NSD2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20165">
        <property type="entry name" value="PWWP_NSD2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19211">
        <property type="entry name" value="SET_NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000004">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000025">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000093">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000201">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000024">
        <property type="entry name" value="Histone-lysine N-methyltransferase NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000057">
        <property type="entry name" value="Histone-lysine N-methyltransferase NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000153">
        <property type="entry name" value="Histone-lysine N-methyltransferase NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041306">
        <property type="entry name" value="C5HCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047443">
        <property type="entry name" value="HMG-box_NSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047441">
        <property type="entry name" value="PHD3_NSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047442">
        <property type="entry name" value="PHD5_NSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055197">
        <property type="entry name" value="PHDvar_NSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047434">
        <property type="entry name" value="PWWP_NSD2_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047435">
        <property type="entry name" value="PWWP_NSD2_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047437">
        <property type="entry name" value="SET_NSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
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                <person name="Rubin C.J."/>
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                <person name="Pauperio F."/>
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                <person name="Soler L."/>
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</entry>
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        </submittedName>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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        </source>
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    <sequence length="333" mass="36401" checksum="C03C7AFBD1E8AD86" modified="2020-06-17" version="1">MGSELGPLSEVLSTFHALIWFLPCMNSLMGYELSFLPEALSTFQALIGFLPCMNSLMGSEIRSPTEAFPTFQALIWFLSCMNTLMGYQLSPLTEAFPTFQALMGFLPAMCSSMGSENEAPMEALSAFQALIGFLPCMNSLMGSETFLMGKTLSTFQTLIRFLPAVSSLMASKFGDVIVALSAFQALIRFLPCMNSVMVSELSSLREALSAFQALIGFLSCMNYLMGQEVSPHTEALSTFEALIWFLPCMNYLMASEMGPFSEALSTLQALIWFLSFMNSLMGSESILPTKSLLTFQALIVILSNGIYFIGSGIGAAIDALSKFQIFIQLPHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6V0</accession>
    <name>A0A670I6V0_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="16 17">
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028719289.1"/>
    </dbReference>
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        <property type="gene ID" value="ENSPMRG00000005031.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048593">
        <property type="term" value="P:camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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</entry>
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        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF27">
        <property type="entry name" value="NEUROPILIN AND TOLLOID-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="358" mass="40490" checksum="6E4292B27C1B6262" modified="2020-06-17" version="1">MGGSEGIVESVQIGKEGKASDTEAVDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMWADEGSRSSRFQMLFTSFQEPPCEANTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEKRKANILDQLTNTSGTIIGVTSCIVVLLIIISVIVQIKQPRKKYVQRKADFDQTVFQEVFEPPHYELCTLRGTGASADLADVADDFENYHKLRRSSSKCIHDHHCGSQLSSTKGSRSNLSTRDTPILTEIQPQPVKPLIQPMNRRNILVMKHSYSQDAADACEIDEIEEVPTTSHRLSRHDKAVQRFCLIGSLNKHESEYNTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBM8</accession>
    <name>A0A670IBM8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like</fullName>
            <ecNumber evidence="13">1.3.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">tRNA-dihydrouridine synthase 1-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">DUS1L</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U16 and U17 in cytoplasmic tRNAs. Affects the level of some mature tRNA and thereby the total cellular translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028572021.1">
        <property type="nucleotide sequence ID" value="XM_028716188.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028572027.1">
        <property type="nucleotide sequence ID" value="XM_028716194.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028572032.1">
        <property type="nucleotide sequence ID" value="XM_028716199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IBM8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009704.1">
        <property type="protein sequence ID" value="ENSPMRP00000009088.1"/>
        <property type="gene ID" value="ENSPMRG00000006116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589760"/>
    <dbReference type="KEGG" id="pmua:114589760"/>
    <dbReference type="CTD" id="64118"/>
    <dbReference type="GeneTree" id="ENSGT00550000075089"/>
    <dbReference type="OMA" id="ISPPVWQ"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102262">
        <property type="term" value="F:tRNA-dihydrouridine16 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102263">
        <property type="term" value="F:tRNA-dihydrouridine17 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000081">
        <property type="entry name" value="Dihydrouridine synthase 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05142">
        <property type="entry name" value="DUF702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="22">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="347"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00077078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="485" mass="54737" checksum="6758882A6F566200" modified="2020-06-17" version="1">MPKLEGFEFWRNTLKGARFVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANYRKENLYCDVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGHYGAFLQEEWKLLQKMIVLANEKLSVPITCKIRVFPEIGKTVKYAQLLEEAGCQLLTVHGRTKEQKGPLAGVASWEHIQAVRKAVNIPVFANGNIQYLSDVEQCIQKTGVQGVMSAEGNLHNPALFEGRNPVVWEMAEEYLEIVQQYPCPLSYVRAHLFKLWHHTLQVHQHLRDELAKVKTLEGLVAVNRELTLHCQEEIASLKEDEKPKGGLPFFHWICQPYVRPGPKEVCKENGTSGMEGSTRGKRALEDADDGNSDGLSKNKQKKKLRNPNKSFDPSLKPKYAKCDQCGNPKGNKCVFNLCRGCCKKRAFRETADCPGHGLLFKTKYEKSLSWKNGQSSLENIEVTAQKGEVEETILLQEAIDGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBQ5</accession>
    <name>A0A670IBQ5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">small monomeric GTPase</fullName>
            <ecNumber evidence="1">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RAP1A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028590317.1">
        <property type="nucleotide sequence ID" value="XM_028734484.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028590318.1">
        <property type="nucleotide sequence ID" value="XM_028734485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IBQ5"/>
    <dbReference type="SMR" id="A0A670IBQ5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009684.1">
        <property type="protein sequence ID" value="ENSPMRP00000009069.1"/>
        <property type="gene ID" value="ENSPMRG00000006096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599364"/>
    <dbReference type="KEGG" id="pmua:114599364"/>
    <dbReference type="CTD" id="5906"/>
    <dbReference type="GeneTree" id="ENSGT00940000160251"/>
    <dbReference type="OMA" id="EYKLVVM"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061028">
        <property type="term" value="P:establishment of endothelial barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000301">
        <property type="term" value="P:negative regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001214">
        <property type="term" value="P:positive regulation of vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032486">
        <property type="term" value="P:Rap protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901888">
        <property type="term" value="P:regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098696">
        <property type="term" value="P:regulation of neurotransmitter receptor localization to postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04175">
        <property type="entry name" value="Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000182">
        <property type="entry name" value="ras-related protein Rap-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038851">
        <property type="entry name" value="Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="184" mass="20987" checksum="42C39290C98E0A92" modified="2020-06-17" version="1">MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICA3</accession>
    <name>A0A670ICA3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mucin 5B, oligomeric mucus/gel-forming</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homomultimer; disulfide-linked. The N- and C-terminus mediate their assembly into higher order structures to form filaments. The CTCK domains of two polypeptides associate in the endoplasmic reticulum to generate intermolecularly disulfide-bonded dimers. These dimers progress to the Golgi apparatus, which is a more acidic environment than the endoplasmic reticulum. Under acidic conditions, the N-termini form non-covalent intermolecular interactions that juxtapose assemblies from different CTCK-linked dimers to produce long, disulfide-linked polymers that remain highly compact until secretion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000009871.1">
        <property type="protein sequence ID" value="ENSPMRP00000009247.1"/>
        <property type="gene ID" value="ENSPMRG00000006188.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162219"/>
    <dbReference type="OMA" id="CTSCDPE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000153">
        <property type="entry name" value="MUC5B isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000674">
        <property type="entry name" value="Mucin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000414">
        <property type="entry name" value="von Willebrand factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058753">
        <property type="entry name" value="TIL_OTOGL_Mucin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF403">
        <property type="entry name" value="MUCIN-5B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25962">
        <property type="entry name" value="TIL_OTOGL_Mucin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025476418" description="Mucin 5B, oligomeric mucus/gel-forming" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="385"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="850"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="1351"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="11">
        <location>
            <begin position="1664"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="10">
        <location>
            <begin position="1891"/>
            <end position="1989"/>
        </location>
    </feature>
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        <location>
            <begin position="1916"/>
            <end position="1965"/>
        </location>
    </feature>
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        <location>
            <begin position="1927"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1931"/>
            <end position="1983"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1990" mass="221586" checksum="BA1A411E84844807" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ID78</accession>
    <name>A0A670ID78_PODMU</name>
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        <recommendedName>
            <fullName evidence="1">Cep192-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670ID78"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="167"/>
            <end position="242"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF22067"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="283" mass="32339" checksum="06AB52AC46C66DBA" modified="2020-06-17" version="1">MEVVKSACSEDFSNTKETPEKLQSLLLDSLVDDTKEATDVPNRLVESKIFRKLVRNDVIQAKPAIMHFGGYIMEHHHQQVLKLLNISSEVINFHVIPPETKYFQIKYSKIQRLVPGLSFTITVDFCADEWRYYCDCLRIHSQGDDTLLVPLHAYPVMNTVEFPSFINLSDVSLGQCKEYVIPLECSCPIDFEFHIDFLQPHKAFTVHPTSGIIPANGKAEIMVTFAPFEYGTAQMKMELWISQFNSKPYICAFTGTSSPRPTLTYVRPVLALNIFLKNHCVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDE8</accession>
    <name>A0A670IDE8_PODMU</name>
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        <recommendedName>
            <fullName evidence="18">Opsin-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">G-protein coupled receptor 136</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">G-protein coupled receptor PGR12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Neuropsin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">OPN5</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028577512.1">
        <property type="nucleotide sequence ID" value="XM_028721679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IDE8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010332.1">
        <property type="protein sequence ID" value="ENSPMRP00000009689.1"/>
        <property type="gene ID" value="ENSPMRG00000006492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593302"/>
    <dbReference type="KEGG" id="pmua:114593302"/>
    <dbReference type="CTD" id="221391"/>
    <dbReference type="GeneTree" id="ENSGT01120000271854"/>
    <dbReference type="OMA" id="MENTTWP"/>
    <dbReference type="OrthoDB" id="5564849at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005502">
        <property type="term" value="F:11-cis retinal binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071492">
        <property type="term" value="P:cellular response to UV-A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990384">
        <property type="term" value="P:hyaloid vascular plexus regression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007604">
        <property type="term" value="P:phototransduction, UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15074">
        <property type="entry name" value="7tmA_Opsin5_neuropsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000104">
        <property type="entry name" value="Opsin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002962">
        <property type="entry name" value="Peropsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01244">
        <property type="entry name" value="PEROPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 22" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="13 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="15 22" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 22 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="25">
        <location>
            <begin position="50"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="358" mass="40089" checksum="F0AB00F4B718A4D9" modified="2020-06-17" version="1">MDSKQNISSEDVSLPPYEQHGDPFESKLSKEADIVAGFYLLVIGIMSTLGNGYVLYMSTQRKKKLRPAEIMTVNLAVCDLGISVLGKPFSIIAFFSHRWIFGWSACRWYGWAGFFFGIGSLITMTAVSLDRYFKICYLSYGTWLKRCHAFICLGIIWSYATFWATIPFAGLGNYAPEPFGTSCTLDWWLAQGSVAGQAFIMNILFFCLLFPTAVIMFSYIKIIAKVKSSTKEVAHYDTRIQKTHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPNSVPIKVSVIPTLLAKSAAMYNPVIYQVIDCKSACCRPCPLKPLQKKTSLKRSQPYTISADNNSEVINETQLDSEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IED9</accession>
    <name>A0A670IED9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">KDM5B</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010784.1">
        <property type="protein sequence ID" value="ENSPMRP00000010121.1"/>
        <property type="gene ID" value="ENSPMRG00000004351.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157076"/>
    <dbReference type="OMA" id="PRCDIGM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16874">
        <property type="entry name" value="ARID_KDM5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15603">
        <property type="entry name" value="PHD1_KDM5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15687">
        <property type="entry name" value="PHD3_KDM5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000023">
        <property type="entry name" value="Lysine (K)-specific demethylase 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000035">
        <property type="entry name" value="PHD transcription factor Rum1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000001">
        <property type="entry name" value="Putative lysine-specific demethylase 5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000001">
        <property type="entry name" value="Putative lysine-specific demethylase 5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047981">
        <property type="entry name" value="KDM5B_ARID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047978">
        <property type="entry name" value="KDM5B_PHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047979">
        <property type="entry name" value="KDM5B_PHD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF3">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="22">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="21">
        <location>
            <begin position="95"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="297"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="23">
        <location>
            <begin position="441"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="1164"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="1471"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
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</entry>
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        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="ARBA" id="ARBA00049650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="131" mass="14695" checksum="DC80207109E0902F" modified="2020-06-17" version="1">MNAALAVTFCLLVALEPVNCQRVQRSLQPWVQGTIAVTVFLVLAMVAFVVNRLWCQDNDDSFEEKNKAFSTSSNKEEMPISNGSEGRYSTTAADFRSEEGPHVYENKVELECRNTPECHSENNIQVLTTCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKP8</accession>
    <name>A0A670IKP8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nephrocystin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NPHP4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSPMRT00000013468.1">
        <property type="protein sequence ID" value="ENSPMRP00000012608.1"/>
        <property type="gene ID" value="ENSPMRG00000008231.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048827"/>
    <dbReference type="OMA" id="FLLEYTF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:ciliary base"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120206">
        <property type="term" value="C:photoreceptor distal connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097470">
        <property type="term" value="C:ribbon synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035845">
        <property type="term" value="P:photoreceptor cell outer segment organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903348">
        <property type="term" value="P:positive regulation of bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22239">
        <property type="entry name" value="NPHP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058687">
        <property type="entry name" value="Ig_NPHP4_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058688">
        <property type="entry name" value="Ig_NPHP4_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058686">
        <property type="entry name" value="Ig_NPHP4_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058685">
        <property type="entry name" value="Ig_NPHP4_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029775">
        <property type="entry name" value="NPHP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058765">
        <property type="entry name" value="NPHP4_C2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058764">
        <property type="entry name" value="NPHP4_SK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31043">
        <property type="entry name" value="NEPHROCYSTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31043:SF3">
        <property type="entry name" value="NEPHROCYSTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26015">
        <property type="entry name" value="Ig_NPH4_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26190">
        <property type="entry name" value="Ig_NPHP4_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26189">
        <property type="entry name" value="Ig_NPHP4_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26187">
        <property type="entry name" value="Ig_NPHP4_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26186">
        <property type="entry name" value="NPHP4_C2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26173">
        <property type="entry name" value="NPHP4_SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NPHP4 C2-like" evidence="3">
        <location>
            <begin position="554"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="NPHP4 SK-like" evidence="2">
        <location>
            <begin position="866"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="NPHP4 Ig-like" evidence="6">
        <location>
            <begin position="929"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="NPHP4 Ig-like" evidence="5">
        <location>
            <begin position="1084"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="NPHP4 Ig-like" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="NPHP4 Ig-like" evidence="4">
        <location>
            <begin position="1281"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1377" mass="154558" checksum="1F0B39CD500E7F93" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IM85</accession>
    <name>A0A670IM85_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEST proteolytic signal-containing nuclear protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in cell cycle regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with UHRF2/NIRF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IM85"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013671.1">
        <property type="protein sequence ID" value="ENSPMRP00000012801.1"/>
        <property type="gene ID" value="ENSPMRG00000008558.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010218"/>
    <dbReference type="OMA" id="EKDMMAD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029169">
        <property type="entry name" value="PCNP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16523">
        <property type="entry name" value="PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16523:SF6">
        <property type="entry name" value="PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15473">
        <property type="entry name" value="PCNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="55" mass="6294" checksum="C7B80FD29CE061F0" modified="2020-06-17" version="1">MPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNMKSHLGNVREHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IP09</accession>
    <name>A0A670IP09_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IP09"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014677.1">
        <property type="protein sequence ID" value="ENSPMRP00000013735.1"/>
        <property type="gene ID" value="ENSPMRG00000009213.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286944"/>
    <dbReference type="OMA" id="WKSHTRE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001576">
        <property type="entry name" value="HKR1, GLI-Kruppel zinc finger family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001273">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000414">
        <property type="entry name" value="Zinc finger protein 398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="563" mass="64394" checksum="799A8C79F4222025" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQX3</accession>
    <name>A0A670IQX3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114601598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028594729.1">
        <property type="nucleotide sequence ID" value="XM_028738896.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594730.1">
        <property type="nucleotide sequence ID" value="XM_028738897.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594731.1">
        <property type="nucleotide sequence ID" value="XM_028738898.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594732.1">
        <property type="nucleotide sequence ID" value="XM_028738899.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028594733.1">
        <property type="nucleotide sequence ID" value="XM_028738900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IQX3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014860.1">
        <property type="protein sequence ID" value="ENSPMRP00000013904.1"/>
        <property type="gene ID" value="ENSPMRG00000009319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601598"/>
    <dbReference type="GeneTree" id="ENSGT00940000162741"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000168">
        <property type="entry name" value="Elongation factor 1-alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="461" mass="50077" checksum="3B0FE1F2B6E97D9F" modified="2020-06-17" version="1">MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKFYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGMGEFEAGISKSGQTREHALLAYTLGVKQLIIGVNKMDSTEPPYSSKRYQEISKEVSAYIKKIGYNPATVAFVPISGWHGDNMLEPSSNMPWFKGWSITRKEGNASGTTLLEALDSIIPPSRPVNKPLRLPLQDVYKIGGIGTVPVGRVETGFLKAGMVVTFAPTNITTEVKSVEMHHEALAEALPGDNVGFNVKNVSVKDIRRGNVAGDSKNDPPMEAGSFSAQVIILNHPGQISAGYAPVLDCHTAHISCKFAELKEKIDRRSGKKLEDDPKSLKTGDAAIVQMIPGKPMCVESFSEYPPLGRFAVRDMRQTVAVGVIKSVEKKASGAAKITKSAIKASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRC2</accession>
    <name>A0A670IRC2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibronectin type III domain-containing protein 3B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Factor for adipocyte differentiation 104</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">HCV NS5A-binding protein 37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FNDC3B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FNDC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587411.1">
        <property type="nucleotide sequence ID" value="XM_028731578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IRC2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015018.1">
        <property type="protein sequence ID" value="ENSPMRP00000014054.1"/>
        <property type="gene ID" value="ENSPMRG00000009401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597983"/>
    <dbReference type="KEGG" id="pmua:114597983"/>
    <dbReference type="CTD" id="64778"/>
    <dbReference type="GeneTree" id="ENSGT00940000157005"/>
    <dbReference type="OMA" id="NACEIAW"/>
    <dbReference type="OrthoDB" id="443915at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000175">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000180">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000185">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000210">
        <property type="entry name" value="Fibronectin type III domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000309">
        <property type="entry name" value="Fibronectin type III domain containing 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000396">
        <property type="entry name" value="Fibronectin type III domain containing 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF44">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN CONTAINING 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1188"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="284"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="389"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="485"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="582"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="681"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="778"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="880"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="967"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1065"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1213" mass="133623" checksum="2FA7342C601233F8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISB6</accession>
    <name>A0A670ISB6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ISB6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015368.1">
        <property type="protein sequence ID" value="ENSPMRP00000014389.1"/>
        <property type="gene ID" value="ENSPMRG00000009591.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018016"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="8">
        <location>
            <begin position="404"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="9">
        <location>
            <begin position="500"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="695" mass="73405" checksum="90A6AFF9776F4654" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IST7</accession>
    <name>A0A670IST7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Catenin alpha-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Alpha N-catenin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
            <location evidence="5">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IST7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015522.1">
        <property type="protein sequence ID" value="ENSPMRP00000014529.1"/>
        <property type="gene ID" value="ENSPMRG00000009693.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234543"/>
    <dbReference type="OMA" id="YMNNVSE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000006">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000633">
        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF23">
        <property type="entry name" value="CATENIN ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00663">
        <property type="entry name" value="VINCULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="389" mass="43467" checksum="42F030BB25653DAE" modified="2020-06-17" version="1">MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHVLAASVEQATQNFLEKGEQIAKESQDLKDELVAAVEDVRKQGETMRIASSEFADDPCSSVKRGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAATRANRDYVFKQVQEAIAGISNAAQATSPTDENKGHTGIGELAAALNEFDNKIILDPMTFSEARFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNDCLEDKIRQRLVQFPELLERRTFTVTWTVHEAQHWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITA8</accession>
    <name>A0A670ITA8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">F-box only protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FBXO30</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1, CUL1 and RBX1/ROC1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028579431.1">
        <property type="nucleotide sequence ID" value="XM_028723598.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028579433.1">
        <property type="nucleotide sequence ID" value="XM_028723600.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028579434.1">
        <property type="nucleotide sequence ID" value="XM_028723601.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028579435.1">
        <property type="nucleotide sequence ID" value="XM_028723602.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028579436.1">
        <property type="nucleotide sequence ID" value="XM_028723603.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028579437.1">
        <property type="nucleotide sequence ID" value="XM_028723604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ITA8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016260.1">
        <property type="protein sequence ID" value="ENSPMRP00000015220.1"/>
        <property type="gene ID" value="ENSPMRG00000010150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594219"/>
    <dbReference type="KEGG" id="pmua:114594219"/>
    <dbReference type="CTD" id="84085"/>
    <dbReference type="GeneTree" id="ENSGT00950000183204"/>
    <dbReference type="OMA" id="SSWQVKE"/>
    <dbReference type="OrthoDB" id="5918172at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22174">
        <property type="entry name" value="F-box_FBXO30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.150:FF:000001">
        <property type="entry name" value="F-box only protein 30"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-BOX ONLY PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="642"/>
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        <location>
            <begin position="75"/>
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        </location>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057742"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00065924"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068845"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="777" mass="85886" checksum="C1D6EE65449C6429" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVT9</accession>
    <name>A0A670IVT9_PODMU</name>
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        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GNG12</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028733132.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028733133.1"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G-protein_gamma"/>
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        <property type="entry name" value="GGL_sf"/>
    </dbReference>
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        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPROTEING"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="73"/>
        </location>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015624.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="73" mass="8126" checksum="5AB00B9C298B5D9F" modified="2020-06-17" version="1">MSSKTSGTTNNIAQARRTVQQLRIEASIERIKVSKASADLMCYCEEHARKDPLLMGIPASENPFKDKKTCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A670IW03_PODMU</name>
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        <submittedName>
            <fullName evidence="5">Coiled-coil domain containing 38</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">CCDC38</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IW03"/>
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        <property type="protein sequence ID" value="ENSPMRP00000015956.1"/>
        <property type="gene ID" value="ENSPMRG00000010660.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002177">
        <property type="term" value="C:manchette"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061827">
        <property type="term" value="C:sperm head"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin-modified histone reader activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:intraciliary anterograde transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120316">
        <property type="term" value="P:sperm flagellum assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF7">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025544476" evidence="3">
        <location>
            <begin position="16"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4200" evidence="4">
        <location>
            <begin position="48"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="482" mass="56474" checksum="D0C5B850B03D2A9C" modified="2020-06-17" version="1">MVILQILFIIEYTLSFFKPTNCRGLKMESNNSNCFKGIQSDKQSITEYINEQKELFLLEYAVKTKQRTIAKLEEMISEEERRAKLAETKLEEDAIAFDEFLKENDRRSVDALKRLDTLCCTSLKYDCLLAYKLSSFHVCSEIANSEDNLRLYLSYEAFLLSVSPKEWQEQQMAKKKLLKKDKRDVSKSLLSFPAREKSRMGSTSFILHQKISKYVILVLSTRNLYCMLYKSLQFPLFSILPEWKLRNNEPEIYFKDPDELLQMYRHLEEQNLSLFQNIQDLSGTLEDARQREHAIVQGMEKRINDIVNEKKALTAARLKEEQKSAELELKIKVFSSGDYNPISMDKSLNTLKKKITEVYRACCGTIEVSSMTAFQMLKAIEIRVSELCEMLEILPPEYLETVETMEKLRAKQRRQRVREDKLKELKRIQEERLKHALERAIAVPKTRVGRKLVFRSQPPEAKQKGVQVVDLTTKSEDDYYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWN4</accession>
    <name>A0A670IWN4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MyoD family inhibitor domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MDFIC</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDFI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IWN4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017301.1">
        <property type="protein sequence ID" value="ENSPMRP00000016206.1"/>
        <property type="gene ID" value="ENSPMRG00000010831.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158685"/>
    <dbReference type="OMA" id="CDQDNTE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030957">
        <property type="term" value="F:Tat protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042308">
        <property type="term" value="P:negative regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050434">
        <property type="term" value="P:positive regulation of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046328">
        <property type="term" value="P:regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030111">
        <property type="term" value="P:regulation of Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="MDFI/MDFIC"/>
    </dbReference>
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        <property type="entry name" value="MYOD FAMILY INHIBITOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15304:SF0">
        <property type="entry name" value="MYOD FAMILY INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15316">
        <property type="entry name" value="MDFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="269" mass="28931" checksum="646F7E37E047DE50" modified="2020-06-17" version="1">MSQAREPLPSGPEGPERAAPAENSFLISLPREKCDRGRTALGEREIREPSNNPNIQVDTEDQPVWGNCTGDDLIGTQPQRLPQPNASPLEKCKEETGKIQIQNGHTRLSNASGMHNGVKCGAPDSRKFSAPVSQKMHRKIQSSLSVNSGSSKKSSAYSHKPGSSPEDCCVHCILSCLFCEFVTLCSLVLGQASCGVCPIEACCCCCGEEMGDDCNCPCDMDCGIMDACCESSDCLEIYSKCRNVDVSHSSHGKNKRELGKTCYTGNASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWN6</accession>
    <name>A0A670IWN6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Gamma-aminobutyric acid type A receptor subunit alpha6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">GABRA6</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IWN6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017693.1">
        <property type="protein sequence ID" value="ENSPMRP00000016593.1"/>
        <property type="gene ID" value="ENSPMRG00000011045.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156722"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099192">
        <property type="term" value="C:cerebellar Golgi cell to granule cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19039">
        <property type="entry name" value="LGIC_ECD_GABAAR_A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000001">
        <property type="entry name" value="Gamma-aminobutyric acid A receptor subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025714749" evidence="18">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="35"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="472" mass="53626" checksum="D6C518ABDFD9F2B8" modified="2020-06-17" version="1">MAWWLPWICFTACLHKVLADDPAADEGDLYSENISRILDKLLDGYDNRLRPGFGGRGSPGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQMWIDERLKFGGPTEILRLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEIPQESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGMLVLSSLPETTLHHSIYPPFFIALCVSHRRVFTSGTLFSSAKENRLLSHSDIHPLHYDCNPVPSCVLDQQRSCPSKNCGWDHHCPHNDYVEHQRPPLFAQGVLCYCHGLVHCCVLCLCLLCTYRVCSCQLLYQSSDSESNEEGSQGSRTSSRALSSYRTGGGRDSLALRLQLQLEETSQLYDISNRSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXP4</accession>
    <name>A0A670IXP4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable imidazolonepropionase</fullName>
            <ecNumber evidence="5">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Amidohydrolase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AMDHD1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028603424.1">
        <property type="nucleotide sequence ID" value="XM_028747591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IXP4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017047.1">
        <property type="protein sequence ID" value="ENSPMRP00000015967.1"/>
        <property type="gene ID" value="ENSPMRG00000010671.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605904"/>
    <dbReference type="KEGG" id="pmua:114605904"/>
    <dbReference type="CTD" id="144193"/>
    <dbReference type="GeneTree" id="ENSGT00390000008645"/>
    <dbReference type="OMA" id="CAPHARW"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000007">
        <property type="entry name" value="Imidazolonepropionase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="13">
        <location>
            <begin position="291"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="432" mass="47227" checksum="327ED7A3557E2100" modified="2020-06-17" version="1">MAGEYKLLLEGAQQLVLVCTKGEKYLLEAGMQHLAVLENGSVVIGKDGYIKAAGDSRAIRKQFSGASFEKVIDCSGKCILPGLVDAHTHPVWAGDRVHEFAMKLAGASYMDIHQAGGGIHFTVEHTRNALEDELFSSFRHRLLRMLRAGSTLVECKSGYGLNLETEVKMLRVIERARRELDIGISSTYCGAHSVPKGESAIEATDDIVSIHLPKLKQLELNGEIHIDNIDVFCEKGVFDLPSTRRILQAGKDLGLQINFHGDELHPMKSAELGAELGAQAVSHLEEISDEGISAMAQAKCAAVLLPTTAYILRLKQPQARKMLKEGVIVALGSDFNPNAYCCSMLMVMHLACVNMKMSMKEALAAATINAAYALGKSHMHGSIETGKQGDLIIINSPRWEHLIYQFGGHQELVEYVIVKGKVVYKNESVLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IY15</accession>
    <name>A0A670IY15_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cyclin-dependent kinase 5 activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CDK5R1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4. Interacts with RASGRF2. The complex p35/CDK5 interacts with CLOCK.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Heterodimer of a catalytic subunit and a regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Endomembrane system</location>
            <topology evidence="17">Lipid-anchor</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the cyclin-dependent kinase 5 activator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028558578.1">
        <property type="nucleotide sequence ID" value="XM_028702745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IY15"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017422.1">
        <property type="protein sequence ID" value="ENSPMRP00000016324.1"/>
        <property type="gene ID" value="ENSPMRG00000010893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581997"/>
    <dbReference type="KEGG" id="pmua:114581997"/>
    <dbReference type="CTD" id="8851"/>
    <dbReference type="GeneTree" id="ENSGT00390000008812"/>
    <dbReference type="OMA" id="IKKTPHP"/>
    <dbReference type="OrthoDB" id="7676799at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:protein kinase 5 complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000025">
        <property type="entry name" value="Cyclin-dependent kinase 5 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004944">
        <property type="entry name" value="CDK5_activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401">
        <property type="entry name" value="CYCLIN DEPENDANT KINASE-5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03261">
        <property type="entry name" value="CDK5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009324">
        <property type="entry name" value="Cdk5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="305" mass="34288" checksum="AF0FCBECFFFB7542" modified="2020-06-17" version="1">MGTVLSLSPSYRKATLFEDGSSTVGHYTAVQNSKNAKDKSLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNVTHLNNENLKKSLSCANLSTFAQNQGTQPPAPNNQISTSKSNLSSVKKTPHPNSNSTGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVATDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSIINLMSPKMLQINADPHYFTQVFADLKNESSQEEKNRLLIGLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IY23</accession>
    <name>A0A670IY23_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BEST2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Forms chloride channels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028573210.1">
        <property type="nucleotide sequence ID" value="XM_028717377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IY23"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017183.1">
        <property type="protein sequence ID" value="ENSPMRP00000016097.1"/>
        <property type="gene ID" value="ENSPMRG00000010746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114590833"/>
    <dbReference type="KEGG" id="pmua:114590833"/>
    <dbReference type="CTD" id="54831"/>
    <dbReference type="GeneTree" id="ENSGT00940000161361"/>
    <dbReference type="OMA" id="APECGCG"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160133">
        <property type="term" value="F:bicarbonate channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005217">
        <property type="term" value="F:intracellularly ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099094">
        <property type="term" value="F:ligand-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF1">
        <property type="entry name" value="BESTROPHIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="7" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="571" mass="64418" checksum="BC7BEE3BECD3C69D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IY26</accession>
    <name>A0A670IY26_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Plexin-A1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PLXNA1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts directly with NRP1 and NRP2. Interacts with PLXN1B. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Interacts with CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3 and DPYSL4/CRMP4. Interacts (via TIG domains) with TREM2; the interaction mediates SEMA6D binding and signaling through TYROBP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028575040.1">
        <property type="nucleotide sequence ID" value="XM_028719207.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000017814.1">
        <property type="protein sequence ID" value="ENSPMRP00000016711.1"/>
        <property type="gene ID" value="ENSPMRG00000011115.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591746"/>
    <dbReference type="CTD" id="5361"/>
    <dbReference type="GeneTree" id="ENSGT01050000244850"/>
    <dbReference type="OMA" id="CIRDCTP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01180">
        <property type="entry name" value="IPT_plexin_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01179">
        <property type="entry name" value="IPT_plexin_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01181">
        <property type="entry name" value="IPT_plexin_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12790">
        <property type="entry name" value="RasGAP_plexin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11271">
        <property type="entry name" value="Sema_plexin_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000005">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000006">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000123">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000320">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001412">
        <property type="entry name" value="Plexin A1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000006">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000071">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000018">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000329">
        <property type="entry name" value="Plexin A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042744">
        <property type="entry name" value="Plexin-A1_Sema"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF35">
        <property type="entry name" value="PLEXIN-A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025629284" description="Plexin-A1" evidence="18">
        <location>
            <begin position="31"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1234"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="19">
        <location>
            <begin position="22"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1257"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1889" mass="211928" checksum="F50F58CE0650EA1B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J0W0</accession>
    <name>A0A670J0W0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal carnitine O-octanoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CROT</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:44860"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77061"/>
            <dbReference type="ChEBI" id="CHEBI:84654"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:17177"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:18102"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="EC" id="2.3.1.137"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.137" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028607319.1">
        <property type="nucleotide sequence ID" value="XM_028751486.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028607320.1">
        <property type="nucleotide sequence ID" value="XM_028751487.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028607321.1">
        <property type="nucleotide sequence ID" value="XM_028751488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J0W0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018113.1">
        <property type="protein sequence ID" value="ENSPMRP00000017002.1"/>
        <property type="gene ID" value="ENSPMRG00000011280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607874"/>
    <dbReference type="KEGG" id="pmua:114607874"/>
    <dbReference type="CTD" id="54677"/>
    <dbReference type="GeneTree" id="ENSGT01150000286999"/>
    <dbReference type="OMA" id="DVWAKDY"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008458">
        <property type="term" value="F:carnitine O-octanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015908">
        <property type="term" value="P:fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051791">
        <property type="term" value="P:medium-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000006">
        <property type="entry name" value="Peroxisomal carnitine O-octanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF67">
        <property type="entry name" value="PEROXISOMAL CARNITINE O-OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="612" mass="69829" checksum="06E7B468C6B49BCC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1F7</accession>
    <name>A0A670J1F7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ATP10D</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="RefSeq" id="XP_028600938.1">
        <property type="nucleotide sequence ID" value="XM_028745105.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028600939.1">
        <property type="nucleotide sequence ID" value="XM_028745106.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028600940.1">
        <property type="nucleotide sequence ID" value="XM_028745107.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028600941.1">
        <property type="nucleotide sequence ID" value="XM_028745108.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028600942.1">
        <property type="nucleotide sequence ID" value="XM_028745109.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028600943.1">
        <property type="nucleotide sequence ID" value="XM_028745110.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028600944.1">
        <property type="nucleotide sequence ID" value="XM_028745111.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028600945.1">
        <property type="nucleotide sequence ID" value="XM_028745112.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028600946.1">
        <property type="nucleotide sequence ID" value="XM_028745113.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000019501.1">
        <property type="protein sequence ID" value="ENSPMRP00000018338.1"/>
        <property type="gene ID" value="ENSPMRG00000012061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604705"/>
    <dbReference type="CTD" id="57205"/>
    <dbReference type="GeneTree" id="ENSGT00940000156728"/>
    <dbReference type="OMA" id="KKYIDCC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000022">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000023">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF84">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE VD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122754" checksum="02E5944724B12805" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2H0</accession>
    <name>A0A670J2H0_PODMU</name>
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        <recommendedName>
            <fullName evidence="6">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J2H0"/>
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        <property type="protein sequence ID" value="ENSPMRP00000018375.1"/>
        <property type="gene ID" value="ENSPMRG00000012089.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157266"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025512244" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14277" checksum="1DC2410A068D3613" modified="2020-06-17" version="1">MKRKLMFYMMQLVLVLLACFSARSASVDPNEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSTTEVFTNIYVTSFGPVSDTDMVSSPKRNKFWHEIILLKIFFPSHFTEISQGTSMLNCITVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2I5</accession>
    <name>A0A670J2I5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J2I5"/>
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        <property type="gene ID" value="ENSPMRG00000011719.1"/>
    </dbReference>
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    <dbReference type="OMA" id="SECNPNC"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="202"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="466" mass="51698" checksum="CFF422ABD830A603" modified="2020-06-17" version="1">MSMTGHSYSLYNAVYAIAHALHALFLSRTKYRGVMEGGLQELQMLQSWQLHPFLRTVSFNNSAGETISFSENGEVDAGFDITNTVAFLNDSFVRVKVGRVGVEATPGQKFSIDDNRMVWHRSFHQVPPLSECNPNCPPGSSKEKKEGEPFCCYDCAPCPQGKISPQKDMVDCVACPKDHYPHRNQSQCIPKTISFLSVKEPLGMSLALIALYLSLLTVVVLVIFIKHQDTPIVRANNRDLTYALLTFLLLCFLCPLIFLSPPERVSCLLRQMAFGLVFTVTVSCVLAKTITVVLAFVATKPGSRMRKWVGKRLASSIVISCSLIQAAICTVWLGTSPPFPDSDMQSVMREIILGCNEGSVALFYCVLGYMGFLAIISFVVAFFARKLPESFNEAKFITFSMFLFCSVWISFVPVYLSTKGKNMVAVEIFSILASSAGLLGSIFAPKCYIILLRPDLNSKEQLIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J671</accession>
    <name>A0A670J671_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Corrinoid adenosyltransferase MMAB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:co(I)rrinoid adenosyltransferase MMAB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MMAB</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cob(I)alamin-[corrinoid adenosyltransferase] + ATP = apo-[corrinoid adenosyltransferase] + adenosylcob(III)alamin + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:56796"/>
            <dbReference type="Rhea" id="RHEA-COMP:14743"/>
            <dbReference type="Rhea" id="RHEA-COMP:14744"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60488"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:56797"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J671"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020264.1">
        <property type="protein sequence ID" value="ENSPMRP00000019084.1"/>
        <property type="gene ID" value="ENSPMRG00000012470.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008432"/>
    <dbReference type="OMA" id="HQACTVV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1200.10:FF:000001">
        <property type="entry name" value="Cob(I)yrinic acid a,c-diamide adenosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="11">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="212" mass="23530" checksum="5D07478AF673E647" modified="2020-06-17" version="1">MNVKDHFPLLFLCSMDAKPRKTTQIPKLYTKTGDQGFSSTFTGERRAKDDQIFDALGTLDELSSAIGLSAEFGSEGGHSFVQELHQVQCVLQDAGSNVATPISSARESHLKRTSFSEKPILELEAWIDHYSEQLPPLTAFILPSGGKSSTALHLSRAICRRAERCVIPLVKMGEADADVAKFLNRLSDYLFVLARYAAMKEGKQEKIYTRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J6S7</accession>
    <name>A0A670J6S7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">A-type potassium channel modulatory protein DPP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dipeptidyl aminopeptidase-like protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dipeptidyl peptidase 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Dipeptidyl peptidase VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DPP6</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homodimer (in vitro). Interacts with KCND2. Identified in a complex with KCND2 and KCNIP2. Forms an octameric complex composed of four DPP6 subunits bound to the KCND2 tetramer. Interacts with KCND3; this interaction modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605729.1">
        <property type="nucleotide sequence ID" value="XM_028749896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J6S7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020500.1">
        <property type="protein sequence ID" value="ENSPMRP00000019309.1"/>
        <property type="gene ID" value="ENSPMRG00000012603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607090"/>
    <dbReference type="CTD" id="1804"/>
    <dbReference type="GeneTree" id="ENSGT00940000156280"/>
    <dbReference type="OMA" id="GERYMDT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF20">
        <property type="entry name" value="DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="18">
        <location>
            <begin position="133"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="17">
        <location>
            <begin position="581"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="803" mass="91338" checksum="BE52C24BFE092299" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8R7</accession>
    <name>A0A670J8R7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KIAA2013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KIAA2013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Brejcha J."/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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            <authorList>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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    </evidence>
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    <sequence length="253" mass="27663" checksum="116E5A67C51FB4DB" modified="2020-06-17" version="1">MSADVWVGSWRPHRPRGPIAALYSSPGPKYALPTNVGYPLHDPSRYRAPAYSFGIRRPQELVGCSPGPGYLIPTNMTMRGKDGIPAFSIYGRPRDVMSFMTPGPGRYSPEKAKNLAYPSAPNYSLASRTKNFDYDQSPGPAAYGLPPMLGPKVIGKSTAPNYSIFGRSMIGSFYEDLSKTPGPCNYRLVDPSVYKNRPPHFSMLARNMPPGDNTLKPGPGAYSPEKVRTSGTRRPLARTQSDPISPLVILIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JBP1</accession>
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            <fullName evidence="7">Transmembrane protein 88B</fullName>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM88 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028596698.1">
        <property type="nucleotide sequence ID" value="XM_028740865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JBP1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023214.1">
        <property type="protein sequence ID" value="ENSPMRP00000021868.1"/>
        <property type="gene ID" value="ENSPMRG00000014206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602527"/>
    <dbReference type="KEGG" id="pmua:114602527"/>
    <dbReference type="CTD" id="643965"/>
    <dbReference type="GeneTree" id="ENSGT00940000163776"/>
    <dbReference type="OMA" id="CAKEWSS"/>
    <dbReference type="OrthoDB" id="9948320at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033355">
        <property type="entry name" value="TMEM88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28628">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 88-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28628:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 88B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="256" mass="29000" checksum="ED0BFED89BEC6422" modified="2020-06-17" version="1">MLGVGQLCRSAALLDQSPSNPAEVSQIRKEAYTDSFEKPTLATTFSVLKVFWGRQEQGDFFEKRFFSGWKPCLIPSIMSDQEMDDYDMDSLSDTSRMIKGLPPYNMDDQLLPMERRSTCGCWAWTCLVAAMNSLAFLLNFLLMAAIFAIVLLPTIVVVYFGFQCHSRVFHSTASYCKTILDDNSSSALIILGFVIMSPLIVVAMAIYCGLVRRLRLFLCFQPWARATYKGVKWRWYEDGGLCGCAKEWSSQVKAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC19</accession>
    <name>A0A670JC19_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BolA family member 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JC19"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022031.1">
        <property type="protein sequence ID" value="ENSPMRP00000020747.1"/>
        <property type="gene ID" value="ENSPMRG00000013470.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047760"/>
    <dbReference type="OMA" id="VHAFSQK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9826" checksum="9510A05D20D057C3" modified="2020-06-17" version="1">LSVEALRERLLQGLEAEHVEVEDTTPGRCATSFKVLVVSPRFRGKALLQRHRLVNEVLVEELKHIHAFEQRTLTPEQWAKEQEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JDI9</accession>
    <name>A0A670JDI9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartyl/asparaginy/proline hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JDI9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022513.1">
        <property type="protein sequence ID" value="ENSPMRP00000021207.1"/>
        <property type="gene ID" value="ENSPMRG00000013782.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161676"/>
    <dbReference type="OMA" id="TFANGRC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051821">
        <property type="entry name" value="Asp/Asn_beta-hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332:SF5">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="108" mass="11604" checksum="2F234D3873809EE7" modified="2020-06-17" version="1">VNANRFGNACFSVLQPGTVLPGTYGPTNTRVRCHLGLKVPPGCELVVGGEPQCWSEGYCLLVDDSFLHTTAHNGSPTDGPRVIFIVDLWHPNVAGPERQALDYIFAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEB9</accession>
    <name>A0A670JEB9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JEB9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022798.1">
        <property type="protein sequence ID" value="ENSPMRP00000021482.1"/>
        <property type="gene ID" value="ENSPMRG00000013944.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000249379"/>
    <dbReference type="OMA" id="CCAWNGS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="128" mass="14674" checksum="039DBC438C92D879" modified="2020-06-17" version="1">MIESHTRKVKPFYWALIIITADHFSIGDLITQTIGWLIRINGEVGWRSLPLCFGLGPLLFIGLFRFLLLRMIVSFFDFSWLVLPLFPVVSLVSWQVSNSSTWLSTCLLLFSTTSTIWLTIWIFSSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEN2</accession>
    <name>A0A670JEN2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Chitotriosidase-1</fullName>
            <ecNumber evidence="6">3.2.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Chitinase-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC114599273</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028590007.1">
        <property type="nucleotide sequence ID" value="XM_028734174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JEN2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022923.1">
        <property type="protein sequence ID" value="ENSPMRP00000021602.1"/>
        <property type="gene ID" value="ENSPMRG00000014014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599273"/>
    <dbReference type="KEGG" id="pmua:114599273"/>
    <dbReference type="GeneTree" id="ENSGT00940000161149"/>
    <dbReference type="OMA" id="NPMTYDF"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000081">
        <property type="entry name" value="Chitinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000220">
        <property type="entry name" value="Chitotriosidase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025648094" description="Chitotriosidase-1" evidence="20">
        <location>
            <begin position="22"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="22">
        <location>
            <begin position="22"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="21">
        <location>
            <begin position="415"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="375"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="465" mass="51390" checksum="47069233191D4FF4" modified="2020-06-17" version="1">MGRAFILACFAILLVFHCSSAFKLVCYFTNWAQYRQGEGKFLPQNIDPNLCTHLIYAFAGMSENKIKTLEWNDETLYRDFQNLKQKNPRLKTLLAIGGWTFGSQKFSAMVATPDTRKTFIDSVIQFVRNYGFNGLDLDWEYPGARGSPAADKMRFTSLVQEMAKEFQAEAQRTGKERLLLSAAVAAGKETIDNGYEVDKISQSLDFINLMTYDFHGSWERVTGHVSPLYPDTDNAVKYWMGKGAPAEKLVLGVPLYGRTFTLSSTQNGVNAPASGPGTAGTFTKEAGFLSYYEICNFNKGATTAVIPGGNAPYSFKGNQWVGYDNVDSIKTKVNYLKQKKLGGAMVWAMDLDDFSGSFCGQGAYPLLQTLKRELGSTGLAPNPKPPVPAEPPRPDAPQPDVPQPDVPQPDAPTADTFCLDKEDGTHADLQDATKYYMCTHKKAFSMPCPTGLTFDNQCKCCNYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFI6</accession>
    <name>A0A670JFI6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heme oxygenase</fullName>
            <ecNumber evidence="7">1.14.14.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HMOX2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = biliverdin IXalpha + CO + Fe(2+) + 3 oxidized [NADPH--hemoprotein reductase] + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21764"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57991"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.14.14.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the heme oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.18" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028561309.1">
        <property type="nucleotide sequence ID" value="XM_028705476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JFI6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024645.1">
        <property type="protein sequence ID" value="ENSPMRP00000023206.1"/>
        <property type="gene ID" value="ENSPMRG00000015069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584030"/>
    <dbReference type="KEGG" id="pmua:114584030"/>
    <dbReference type="CTD" id="3163"/>
    <dbReference type="GeneTree" id="ENSGT00390000017673"/>
    <dbReference type="OMA" id="NRAFEYN"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042167">
        <property type="term" value="P:heme catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000001">
        <property type="entry name" value="Heme oxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018207">
        <property type="entry name" value="Haem_oxygenase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF2">
        <property type="entry name" value="HEME OXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00593">
        <property type="entry name" value="HEME_OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="312" mass="35378" checksum="4068E4D5E593005C" modified="2020-06-17" version="1">MSSDVTEALEEPENLSYEELEEDDNVSATDLSELLKEGTKESHDRAENTQFVKDFLKGRIKRELFKLGTVALYFTYSALEEEMERNKDQPGFTPLYFPLELHRKEALMKDLEYFYGEGWREKVQCSEATQRYIDRIRHVGQHEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGVQFYIFDNISNPQQFKQFYRARLNALDLDKGTKERIVEEANKAFEFNMQVFEELDKIGALLAEETQEGGLPVHDGKGDLRKCPYYATKLGAAEVSSCPCHVALALLKLPTVQLVLAACVAVAAGVVAWYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JGV1</accession>
    <name>A0A670JGV1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein cramped-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cramped chromatin regulator homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Hematological and neurological expressed 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CRAMP1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cramped family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000025120.1">
        <property type="protein sequence ID" value="ENSPMRP00000023671.1"/>
        <property type="gene ID" value="ENSPMRG00000015163.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003337"/>
    <dbReference type="OMA" id="YLMMGCP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000439">
        <property type="entry name" value="Cramped chromatin regulator homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055315">
        <property type="entry name" value="Cramped-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677">
        <property type="entry name" value="CRAMPED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677:SF1">
        <property type="entry name" value="PROTEIN CRAMPED-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="177"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1180"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1311"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1123"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1188"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1242"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1312"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1333" mass="142184" checksum="2A337640C6A7FA3A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHE5</accession>
    <name>A0A670JHE5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">D2HGDH</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028586782.1">
        <property type="nucleotide sequence ID" value="XM_028730949.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586783.1">
        <property type="nucleotide sequence ID" value="XM_028730950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JHE5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024478.1">
        <property type="protein sequence ID" value="ENSPMRP00000023044.1"/>
        <property type="gene ID" value="ENSPMRG00000014960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597736"/>
    <dbReference type="KEGG" id="pmua:114597736"/>
    <dbReference type="CTD" id="728294"/>
    <dbReference type="GeneTree" id="ENSGT00550000075086"/>
    <dbReference type="OMA" id="YNEDWMR"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="15">
        <location>
            <begin position="134"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="560" mass="62155" checksum="0AE1C88417073BCE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJF1</accession>
    <name>A0A670JJF1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JJF1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026501.1">
        <property type="protein sequence ID" value="ENSPMRP00000024978.1"/>
        <property type="gene ID" value="ENSPMRG00000016145.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159742"/>
    <dbReference type="OMA" id="LYKERCW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF16">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="447" mass="45195" checksum="A9A579891308C1B3" modified="2020-06-17" version="1">MPGQNKKATSPTAATTPKRLATSAARPSSLTPKEPKPKGTDAKSPDKRTSPLKPPSATTPRPAAKSSPATPRPSTALASTNAQSARSTATSPPKRPSTIKTDAKPADAKKTVAKSPSADLSRPKSAPASTAAKSSATTPTAAAPGLPGAAASRPKPATPRLSGTGSSAAEPKKASTLKTAPKTSPVAKPSRPPTSSVSAPDLKNVRSKIGSTDNIKHQPGGGRAKVERKAESAGAARKPELNAVSKTAPTKTAVSKEGAPKQPNGKVQIVSKKANYSHVQSKCGSKDNIKHVPGGGNVPNTQRPSSGVHSQSATAPRPSQGSTHVQILNKKIDLSKVSSKCGSKANIKHKPGGGDVKIENQKLNFKEKAQAKVGSLDNVGHVPAGGTVKTEGGEEAAPQNGAVTAPPPGGSPPTQENGVGLPTPAQGGGGGDQREIQCFDTHIQETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKR9</accession>
    <name>A0A670JKR9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC6A13</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JKR9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026499.1">
        <property type="protein sequence ID" value="ENSPMRP00000024976.1"/>
        <property type="gene ID" value="ENSPMRG00000015408.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157478"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005369">
        <property type="term" value="F:taurine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF111">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="625" mass="70369" checksum="0CFD35152FE2FDB3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JL70</accession>
    <name>A0A670JL70_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">WDR1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JL70"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026205.1">
        <property type="protein sequence ID" value="ENSPMRP00000024695.1"/>
        <property type="gene ID" value="ENSPMRG00000015959.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009416"/>
    <dbReference type="OMA" id="LTIVACT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030043">
        <property type="term" value="P:actin filament fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043297">
        <property type="term" value="P:apical junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042247">
        <property type="term" value="P:establishment of planar polarity of follicular epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045199">
        <property type="term" value="P:maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002446">
        <property type="term" value="P:neutrophil mediated immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990266">
        <property type="term" value="P:neutrophil migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030220">
        <property type="term" value="P:platelet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000203">
        <property type="entry name" value="WD repeat domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="302" mass="32979" checksum="A547091241F309B5" modified="2020-06-17" version="1">MRTIRISPFASSRVTVNQYNVLRCIKMGGNPISTLEAMMGILYWDSETGENDSFSGKGHTNQVSRMAVDESEQLVSCSMDDTVRYTSLSKKDTSGQDVIKMDVQPKCIAVGPGGYAVVICIGEIVLMKDKKKCFAIDNPGFEPEVVAVHPGGGMAAVGGTDGKVYLYAVQGTSLKKEEKTLEAKGPVTDLAYSHDGAFLAVTDASKAVTVFSVADDYAEHNIFYGHHAKIVCIAWSPDNEHFASGGMDMMVYVWTVSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWSISYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JMX8</accession>
    <name>A0A670JMX8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cortexin 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JMX8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026346.1">
        <property type="protein sequence ID" value="ENSPMRP00000024829.1"/>
        <property type="gene ID" value="ENSPMRG00000016048.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154412"/>
    <dbReference type="OMA" id="FSWLMEA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020066">
        <property type="entry name" value="Cortexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16736">
        <property type="entry name" value="CORTEXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16736:SF1">
        <property type="entry name" value="CORTEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11057">
        <property type="entry name" value="Cortexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9003" checksum="AC4EF7DE74067D64" modified="2020-06-17" version="1">IMDGESFTSAFFSSGNIPAETGITLEQKTTFVFVVLLFIFLGILIVRCFRILLDPYRSMPTSTWADGINGLEKGQFDYALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JN41</accession>
    <name>A0A670JN41_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Limb and CNS expressed 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LIX1L</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LIX1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JN41"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028083.1">
        <property type="protein sequence ID" value="ENSPMRP00000026473.1"/>
        <property type="gene ID" value="ENSPMRG00000017117.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005869"/>
    <dbReference type="OMA" id="DWVAREH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029270">
        <property type="entry name" value="LIX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF3">
        <property type="entry name" value="LIX1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14954">
        <property type="entry name" value="LIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="325" mass="35965" checksum="51A6948D5776433C" modified="2020-06-17" version="1">MESLRVQRLQPGVGGTLRSLRPGVTAGASLAVASAPRRRRRPRRRSGCPGSSPPGAAATGPPAVLREAVEAVVRSFAKHTQGYGRVNVVEALQEFWQMKQSRGADLKNGALVVYEMVPSNSPPYVCYVTLPGGSCFGSFQFCPTKAEARRSAAKIALMNSVFNEHPSRRITDEFIEKSVSEALASFNGNREEADNPSTGIGAFRFMLESNKGKSMLEFQELMTVFQLLHWNGSLKAMRERQCSRQEVLAHYSHRALDDDIRNQMAMDWVNREQNIPGALSRELASTERELDEARLAGKELRFHKEKKDILMLAAGQLGNMHSSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQC2</accession>
    <name>A0A670JQC2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA repair endonuclease XPF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">DNA excision repair protein ERCC-4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ERCC4</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer composed of ERCC1 and ERCC4/XPF. Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-ERCC4/XPF complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028561913.1">
        <property type="nucleotide sequence ID" value="XM_028706080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JQC2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027238.1">
        <property type="protein sequence ID" value="ENSPMRP00000025659.1"/>
        <property type="gene ID" value="ENSPMRG00000016623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584320"/>
    <dbReference type="KEGG" id="pmua:114584320"/>
    <dbReference type="CTD" id="2072"/>
    <dbReference type="GeneTree" id="ENSGT00390000004394"/>
    <dbReference type="OMA" id="THILDIM"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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                <person name="Perez I de Lanuza G."/>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
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                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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                <person name="Soler L."/>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        </subcellularLocation>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF3">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="380" mass="41095" checksum="9B13EB628816232A" modified="2020-06-17" version="1">MMESSTNLDVGAQLIVEDCSGSYSLSHMPDIKVEPHLDSSVEEGPAQSVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLVNSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQILGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKILLEHGADPTIETDSGYNSMDLAVALGHRSGEYSSALGFTFKGWCSFFVSAASPFGGSQNAQAFTVASGEAFFITIYSSGSLCRAGGRQLSSVHALHSLPPPLDHLTVILYAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRG7</accession>
    <name>A0A670JRG7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein MDM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MDM1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MDM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JRG7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029268.1">
        <property type="protein sequence ID" value="ENSPMRP00000027598.1"/>
        <property type="gene ID" value="ENSPMRG00000017788.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000029284.1">
        <property type="protein sequence ID" value="ENSPMRP00000027610.1"/>
        <property type="gene ID" value="ENSPMRG00000017788.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004106"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046600">
        <property type="term" value="P:negative regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029136">
        <property type="entry name" value="MDM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32078">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32078:SF1">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15501">
        <property type="entry name" value="MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="444"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="666"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
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        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
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        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="717"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010494"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013508"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="729" mass="82170" checksum="604BC33923E1535F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRQ0</accession>
    <name>A0A670JRQ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JRQ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028165.1">
        <property type="protein sequence ID" value="ENSPMRP00000026550.1"/>
        <property type="gene ID" value="ENSPMRG00000017165.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156392"/>
    <dbReference type="OMA" id="LMMSYED"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042758">
        <property type="entry name" value="IGSF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44699">
        <property type="entry name" value="IMMUNOGLOBULIN SUPERFAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44699:SF2">
        <property type="entry name" value="IMMUNOGLOBULIN SUPERFAMILY MEMBER 11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="266" mass="29029" checksum="42A6AB3296441897" modified="2020-06-17" version="1">MNPPDTATPNIGIIQLTVFVPPSRPRCSSDGDGEEGGSLQFSCTVDEGMPTPTFTWEKIPPDAQPLMMSYEDGKRALLTLQNLTTQASGLYRCTASNMLGSTSCVLELRVHVTSHGTTSLAVGISLMLTMGLVLMTLFALVLWLHHQSVEKQRELEQDNARKKHRTDSFTLGRLIVVKSPSGANPAASPITKPLWIFTSSTPNTTYAHREWRPEQGNLSQATLPGGPRQPWGRWRSNSLSEEQGSSSGSEEGKQPGPFPKPRGFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTN5</accession>
    <name>A0A670JTN5_PODMU</name>
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        <recommendedName>
            <fullName evidence="16">Synaptic vesicle glycoprotein 2A</fullName>
        </recommendedName>
    </protein>
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        <name evidence="20" type="primary">SV2A</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566268.1">
        <property type="nucleotide sequence ID" value="XM_028710435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JTN5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029510.1">
        <property type="protein sequence ID" value="ENSPMRP00000027821.1"/>
        <property type="gene ID" value="ENSPMRG00000017961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586708"/>
    <dbReference type="KEGG" id="pmua:114586708"/>
    <dbReference type="CTD" id="9900"/>
    <dbReference type="GeneTree" id="ENSGT00950000182940"/>
    <dbReference type="OMA" id="NDKSMVF"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
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        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17439">
        <property type="entry name" value="MFS_SV2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000009">
        <property type="entry name" value="Synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055415">
        <property type="entry name" value="LD_SV2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022308">
        <property type="entry name" value="SV2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01299">
        <property type="entry name" value="synapt_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF11">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23894">
        <property type="entry name" value="LD_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="19">
        <location>
            <begin position="157"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="730" mass="82956" checksum="E41ADF99CE5AEFC2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTW4</accession>
    <name>A0A670JTW4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JTW4"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="139" mass="15515" checksum="7FFA510B2B302A53" modified="2020-06-17" version="1">MEDLTEVITGIWNSILTTGNLFVYSSSKGSLRLCDMRASALCDKHFKLFEEPEDPSSRSFFSEIISSVSDVKFSHSGRYMLARDYLTVKGKQQGKWRTRAAIASALCGRTWLLRQAPANCSGSCTSHLPLFLGIWAEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JU41</accession>
    <name>A0A670JU41_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SLC31A2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028571033.1">
        <property type="nucleotide sequence ID" value="XM_028715200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JU41"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027992.1">
        <property type="protein sequence ID" value="ENSPMRP00000026387.1"/>
        <property type="gene ID" value="ENSPMRG00000017066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589116"/>
    <dbReference type="KEGG" id="pmua:114589116"/>
    <dbReference type="CTD" id="1318"/>
    <dbReference type="GeneTree" id="ENSGT00940000159996"/>
    <dbReference type="OMA" id="SYNIWIF"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF8">
        <property type="entry name" value="PROTEIN SLC31A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="145" mass="16437" checksum="FCC7213FB071421F" modified="2020-06-17" version="1">MMQMFFYFSDKVVLLFDFWKTHTPAGMVFSVLVIMLLAVLYEFIKAGKAKVLQYTMPPSIASSISQETLREPERASINTGLEQLSSSPKNWFSWHVVQTLLHVVQVVLGYLVMLAVMSYNTWIFLGVIAGSAIGYYIAYPLISPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUG7</accession>
    <name>A0A670JUG7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable U3 small nucleolar RNA-associated protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UTP11</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JUG7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030564.1">
        <property type="protein sequence ID" value="ENSPMRP00000028813.1"/>
        <property type="gene ID" value="ENSPMRG00000018632.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005813"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="298" mass="34592" checksum="AFF40932F326F057" modified="2020-06-17" version="1">MSAAFKKAGKSRQREHRERSQPASRKNLGILEKKKDYKLRANDYHKKRNALQALRRKAEEKNPDEFYYKMTRVQLQDGVHIIKKQEEETTLEQRKLMKTQDLKYIEMKRVAEVKKIERLKSELHLLEAEGKQPNKHTFFFDTKKEVQRFDIATHLNTAPELVGRVYNRPTLETLRKEAVRGATTQAQLKKLARQRKSQYSLLKQRIERERKMFVIAQKLQTRKDLLVREQTVSLPSTYHCFPLLLAEVAVSCYCLTVASPASFPGNMGGGQCVSPERISQPFLLPKGYVGSSTTSLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JW59</accession>
    <name>A0A670JW59_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JW59"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030432.1">
        <property type="protein sequence ID" value="ENSPMRP00000028691.1"/>
        <property type="gene ID" value="ENSPMRG00000018536.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182866"/>
    <dbReference type="OMA" id="SFPRTHF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF3">
        <property type="entry name" value="NXPE FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="304" mass="34881" checksum="106AF1BFE6229949" modified="2020-06-17" version="1">MMFFITISRKGFLLTLGLAGFLILSYTLYRRVFKITLFGDHMKEPEDFQDALETNEDFCLRFMGNRICQTENAAQCRTRVQRWKKEQEVKEILTKLDQIMPSITFTDIMTTTSARNSKATILNQKGSYCIGDPLMVRLDLYNHLGKRKEYGGDFLRARIYSSSLRAGASGHITDYKNGTYLVNFTLFWEGDVRVSILLIHPSEGVSALWAARKKGYDKIAFTGTFLNGTSCVCTKCGFVIETNAELCEYLDERDQEAFYCVKPENVPCEAFVLLTTDNKPITYLTSLEQSLFRRCLQFYIRPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYW7</accession>
    <name>A0A670JYW7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="3">2.7.7.49</ecNumber>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114589440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="3"/>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028571635.1">
        <property type="nucleotide sequence ID" value="XM_028715802.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000032325.1">
        <property type="protein sequence ID" value="ENSPMRP00000030478.1"/>
        <property type="gene ID" value="ENSPMRG00000019730.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589440"/>
    <dbReference type="KEGG" id="pmua:114589440"/>
    <dbReference type="GeneTree" id="ENSGT00940000166838"/>
    <dbReference type="OMA" id="HAISECT"/>
    <dbReference type="OrthoDB" id="9906564at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="13">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="14">
        <location>
            <begin position="438"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="1028"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1264"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1311"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1338" mass="148553" checksum="12EBDE40893BE756" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0W4</accession>
    <name>A0A670K0W4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat flightless-interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LRRFIP2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LRRFIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028607330.1">
        <property type="nucleotide sequence ID" value="XM_028751497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K0W4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030357.1">
        <property type="protein sequence ID" value="ENSPMRP00000028617.1"/>
        <property type="gene ID" value="ENSPMRG00000018496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607882"/>
    <dbReference type="KEGG" id="pmua:114607882"/>
    <dbReference type="CTD" id="9209"/>
    <dbReference type="GeneTree" id="ENSGT00530000063564"/>
    <dbReference type="OMA" id="GNVIRME"/>
    <dbReference type="OrthoDB" id="10028421at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030275">
        <property type="term" value="F:LRR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4090:FF:000001">
        <property type="entry name" value="leucine-rich repeat flightless-interacting protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019139">
        <property type="entry name" value="LRRFIP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212">
        <property type="entry name" value="LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212:SF6">
        <property type="entry name" value="LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09738">
        <property type="entry name" value="LRRFIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="376"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="641"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="732" mass="83287" checksum="DC22A423C52E19A7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2A5</accession>
    <name>A0A670K2A5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kell metallo-endopeptidase (Kell blood group)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KEL</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_028568675.1">
        <property type="nucleotide sequence ID" value="XM_028712842.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028568677.1">
        <property type="nucleotide sequence ID" value="XM_028712844.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028568678.1">
        <property type="nucleotide sequence ID" value="XM_028712845.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028568679.1">
        <property type="nucleotide sequence ID" value="XM_028712846.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028568680.1">
        <property type="nucleotide sequence ID" value="XM_028712847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K2A5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030850.1">
        <property type="protein sequence ID" value="ENSPMRP00000029082.1"/>
        <property type="gene ID" value="ENSPMRG00000018800.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587948"/>
    <dbReference type="KEGG" id="pmua:114587948"/>
    <dbReference type="CTD" id="3792"/>
    <dbReference type="GeneTree" id="ENSGT00940000156050"/>
    <dbReference type="OMA" id="CLEHHYA"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF128">
        <property type="entry name" value="KELL BLOOD GROUP GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="78"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="530"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="724" mass="83605" checksum="3B2B8671C13CF2FE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2Z9</accession>
    <name>A0A670K2Z9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC114589552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028571826.1">
        <property type="nucleotide sequence ID" value="XM_028715993.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028571827.1">
        <property type="nucleotide sequence ID" value="XM_028715994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K2Z9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031848.1">
        <property type="protein sequence ID" value="ENSPMRP00000030034.1"/>
        <property type="gene ID" value="ENSPMRG00000019420.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589552"/>
    <dbReference type="KEGG" id="pmua:114589552"/>
    <dbReference type="GeneTree" id="ENSGT00390000011425"/>
    <dbReference type="OMA" id="CQNYPDL"/>
    <dbReference type="OrthoDB" id="8778600at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034121">
        <property type="term" value="P:regulation of toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027869">
        <property type="entry name" value="TASL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14889:SF2">
        <property type="entry name" value="GENE 6377-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14889">
        <property type="entry name" value="RCG36411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15133">
        <property type="entry name" value="TASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="304" mass="34496" checksum="6689AE41F7495596" modified="2020-06-17" version="1">MLAESILINFAYQEEWPDKTHQSQTLREVGEDPWQKQFKDTDANGDFCTESKKQSAEKVALMCCDKERGQEVPQQNFLQKPPARRCNNIPQSTPQCIPRQEQHCENELDLYRSWSGQSLYQNYPDLHIGGDHIADHTCDSGCIMDQTYDGLSAGPVLFSKDIPLGHSPLNEPVLKSKSVKFWHGEEVGEKSMTFHKQPLSNSILNNYMEAEVQELYKQFLEEKLTRCSSLTHFLTSNMLVNNISEVNLQLPHEKHGEASKATQTLFHSLARLGLQNTGSGNSSEFSTPNLQISTPHCRRKPSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3V2</accession>
    <name>A0A670K3V2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methanethiol oxidase</fullName>
            <shortName evidence="3">MTO</shortName>
            <ecNumber evidence="3">1.8.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Selenium-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SELENBP1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="EC" id="1.8.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organosulfur degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="3">May associate with Golgi membrane. May associate with the membrane of autophagosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the selenium-binding protein family.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.4" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670K3V2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034159.1">
        <property type="protein sequence ID" value="ENSPMRP00000032218.1"/>
        <property type="gene ID" value="ENSPMRG00000020868.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014244"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
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            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="944"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="962"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1122"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1151"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1384" mass="146654" checksum="81F207B90B506B60" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7G1</accession>
    <name>A0A670K7G1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Hyperpolarization activated cyclic nucleotide gated potassium channel 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7G1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032566.1">
        <property type="protein sequence ID" value="ENSPMRP00000030707.1"/>
        <property type="gene ID" value="ENSPMRG00000019886.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156523"/>
    <dbReference type="OMA" id="WEEVRYP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
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        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF11">
        <property type="entry name" value="POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 2"/>
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    </dbReference>
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        <property type="entry name" value="Ion_trans"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport N-terminal" evidence="9">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="139"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08412"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030707.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33325" checksum="B307858CDB12345A" modified="2020-06-17" version="1">MRTGGGGGGGGAPTAASAASSGCASPAASSSPAASPASKGRLLSLRGGGMGSRAGKGGSPNGECRRGGGEEGVSSGPDPGEPGGSQASFMQRQFSAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVMNFRTGIVIEDNTEIILDPERIKKKYLKTWFVVDLVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEVGLFIHLKKCQMWKIDGPQKDIAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7W4</accession>
    <name>A0A670K7W4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Signal peptide peptidase-like 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SPPL2B</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
            <orientation evidence="3">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7W4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035733.1">
        <property type="protein sequence ID" value="ENSPMRP00000033683.1"/>
        <property type="gene ID" value="ENSPMRG00000021802.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158753"/>
    <dbReference type="OMA" id="IAPVNCP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02129">
        <property type="entry name" value="PA_hSPPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000006">
        <property type="entry name" value="Putative signal peptide peptidase-like 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF39">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="21">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="542"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="633" mass="69546" checksum="932D15E57B863C19" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAX2</accession>
    <name>A0A670KAX2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane serine protease 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMPRSS4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028564711.1">
        <property type="nucleotide sequence ID" value="XM_028708878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KAX2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034735.1">
        <property type="protein sequence ID" value="ENSPMRP00000032759.1"/>
        <property type="gene ID" value="ENSPMRG00000021228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585957"/>
    <dbReference type="KEGG" id="pmua:114585957"/>
    <dbReference type="CTD" id="56649"/>
    <dbReference type="GeneTree" id="ENSGT00940000159163"/>
    <dbReference type="OMA" id="YYFFCTK"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035821">
        <property type="term" value="P:modulation of process of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF17">
        <property type="entry name" value="SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15494">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="102"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="205"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="436" mass="47803" checksum="C6BAE6A39D9861EC" modified="2020-06-17" version="1">MDKDTEQPLNSRESSLTDKALTRKEAFIRIGIPVIAAILCIGILITAIFLIKIAVESYYFFCSQTYKFIPLNLQCDGSVDCAWGEDEIGCVQQMPDSTIVGVRLSRDRSSLQVRDRESGHWAWACHDDAFDLAMATAACKQMGYSSVPTFSPVAAGDKQQGQLLRQVILQGGELRWTDSERQCPSGSIISLSCSSCGHNSKSPRVVGGGPASIKTWPWQASLQHKGQHVCGGSIIDPQWVLTAAHCFRTNLVTKYWQVKGGSEIFSNATAVPVEKVFVIDVKYMFPKDEDIALVKLQTPLNLPGSVKPICLPFFDDEMVPGTPLWVTGWGSTKQDGTLSKELQEAQVELIDSRICNAPDAYHGEVTEKMLCAGRDRGRADTCQGDSGGPLVHRQGPWHIVGIVSWGHGCGSPSTPGVYTKVQAYLNWIYTILRTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBK9</accession>
    <name>A0A670KBK9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CIDE-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KBK9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035791.1">
        <property type="protein sequence ID" value="ENSPMRP00000033740.1"/>
        <property type="gene ID" value="ENSPMRG00000021868.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018596"/>
    <dbReference type="OMA" id="VGAKKIM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003508">
        <property type="entry name" value="CIDE-N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306">
        <property type="entry name" value="CELL DEATH ACTIVATOR CIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306:SF9">
        <property type="entry name" value="LIPID TRANSFERASE CIDEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02017">
        <property type="entry name" value="CIDE-N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51135">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="228" mass="25746" checksum="0E52040030DE85EF" modified="2020-06-17" version="1">MDYAKKSLCLLSPRSLTKVVSCDSNAPQARPYRVSNCDRTVRKGIMADSLRDLHEKVRSALLLAGNISIVLDEDGTTVETEEFFQTLEDGTVLLVLTKGQTWRPAKVSQWTAGYQLSLSHKPRRRIDVACVTFDLYKTDPRDFIGCLNVKATLYGTYSMSYDVQCYGAKRIMMEALRWTLFTMQATGHVLLGTSCYMQQLLDATEEPKEENASPRCLLQSPPTRKMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBR7</accession>
    <name>A0A670KBR7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leukocyte receptor cluster member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LENG1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KBR7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034195.1">
        <property type="protein sequence ID" value="ENSPMRP00000032252.1"/>
        <property type="gene ID" value="ENSPMRG00000020908.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048131"/>
    <dbReference type="OMA" id="WYEELPK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="254" mass="29449" checksum="4F411388DB2B388A" modified="2020-06-17" version="1">MNILPKKSWHVRNKDNVAKVRRDEAEAEAQRQKKEARALLAEQEARTEFLRKKARLSAPEGDDGSSDILALGSERPSRHLNLFQELEESGNKEYEEEKRQEKERREKALGILTYLGQSSAEAQTSRPWYQELPERSEAVAKDEKLKGKLDPLAEMERHLRKKKGSHKKDGKKDKRETCRSEGQRPAPSSASSSLEQLRQERLRREKAERARAESLLAQRAGTLPLQEEETDERKRGYNSQFNPQLARKRVWEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBU1</accession>
    <name>A0A670KBU1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KBU1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036368.1">
        <property type="protein sequence ID" value="ENSPMRP00000034276.1"/>
        <property type="gene ID" value="ENSPMRG00000022256.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162286"/>
    <dbReference type="OMA" id="CESQAGI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="336" mass="38403" checksum="B29AA1CA591FB7D8" modified="2020-06-17" version="1">MDMDMELNMDMEQLIGSKLGKEYDKAVYCLPAYLTYMQNSSCESQAGIKIAGRNINSLRYAADTTLMAESEEELKNLLMRMKEESAKYGPKLNIKKTKIMATGPITSWQIEGEEMEAGRDFTFLGSMITADGDSSHEIKRRLLLGRKAMANLDSILKSRDITLPTKVRIVKAMVSPVVMYGSESWTIKKADRQRIDAFELWCWRRLLRVPWTARRSNLSILKEISPECSLEGQILKLRLQYFGHLRRREDSLEKTLMLGKMEGTRRRGRPRMRWLDSVLEATSMSLTKLREAVEDRSAGRALVHGVTKSRTRLNNKVYTHTGPGLETKLQARILGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCM8</accession>
    <name>A0A670KCM8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerases I, II, and III subunit RPABC4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-directed RNA polymerase II subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">POLR2K</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028592225.1">
        <property type="nucleotide sequence ID" value="XM_028736392.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592226.1">
        <property type="nucleotide sequence ID" value="XM_028736393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592227.1">
        <property type="nucleotide sequence ID" value="XM_028736394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KCM8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034549.1">
        <property type="protein sequence ID" value="ENSPMRP00000032582.1"/>
        <property type="gene ID" value="ENSPMRG00000021106.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600375"/>
    <dbReference type="KEGG" id="pmua:114600375"/>
    <dbReference type="CTD" id="5440"/>
    <dbReference type="GeneTree" id="ENSGT00390000008918"/>
    <dbReference type="OMA" id="IYLCADC"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="58" mass="6929" checksum="239BA27981ED707C" modified="2020-06-17" version="1">MDTQKDAPPPKQQPMIYICGECHTENEIKARDPIRCRECGYRIMYKKRTKRLVVFDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGJ2</accession>
    <name>A0A670KGJ2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KGJ2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035902.1">
        <property type="protein sequence ID" value="ENSPMRP00000033847.1"/>
        <property type="gene ID" value="ENSPMRG00000021958.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00980000198589"/>
    <dbReference type="OMA" id="KTVPPCK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33426:SF30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33426">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="369" mass="39655" checksum="B83185972FDDA555" modified="2020-06-17" version="1">MNSLMGSEMGAPSEALSTFQALIGFLPCMNYSMGSQMVAVIEALSTLQALIGFLPCMNSSMASEIGAISEALSTFQALIGFLPCMNSVMGSETGANSEAPSTFEALIGFLPCMSSLMQSEFRPLPEVLPTFEALIGFLPCMSSLMQSEFRPLPEVLPTFEALIGFLSCMNSLMGSESVPLTEALPTLQALIGFLPCMNSLMGSEITTQTKALSTFQAVIRFFPCMNSLMESEIHLLTKALSTFQAVIRFMPSMNSLMENESVLPAEALPAFQALIGFLACMSFLMQSELGPIPKALPAFKALIGFFSCMSSLMGSETVPETKALPTFQAMIGFLPCMDSSMQSKITFLTKALPTFQALIGFLPCMNSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIG7</accession>
    <name>A0A670KIG7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="12 16">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TYK2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12 16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="12 16"/>
    <dbReference type="RefSeq" id="XP_028567690.1">
        <property type="nucleotide sequence ID" value="XM_028711857.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028567691.1">
        <property type="nucleotide sequence ID" value="XM_028711858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KIG7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039353.1">
        <property type="protein sequence ID" value="ENSPMRP00000037168.1"/>
        <property type="gene ID" value="ENSPMRG00000023918.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587501"/>
    <dbReference type="CTD" id="7297"/>
    <dbReference type="GeneTree" id="ENSGT00940000159869"/>
    <dbReference type="OMA" id="QAKHEFV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042022">
        <property type="term" value="C:interleukin-12 receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072536">
        <property type="term" value="C:interleukin-23 receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005131">
        <property type="term" value="F:growth hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060397">
        <property type="term" value="P:growth hormone receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140105">
        <property type="term" value="P:interleukin-10-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035722">
        <property type="term" value="P:interleukin-12-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038155">
        <property type="term" value="P:interleukin-23-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032819">
        <property type="term" value="P:positive regulation of natural killer cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051142">
        <property type="term" value="P:positive regulation of NK T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032729">
        <property type="term" value="P:positive regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060337">
        <property type="term" value="P:type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060333">
        <property type="term" value="P:type II interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05080">
        <property type="entry name" value="PTKc_Tyk2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000110">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000084">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000135">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000114">
        <property type="entry name" value="Tyrosine-protein kinase JAK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041155">
        <property type="entry name" value="FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041046">
        <property type="entry name" value="FERM_F2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051286">
        <property type="entry name" value="JAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041381">
        <property type="entry name" value="JAK1-3/TYK2_PHL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016251">
        <property type="entry name" value="Tyr_kinase_non-rcpt_Jak/Tyk2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016045">
        <property type="entry name" value="Tyr_kinase_non-rcpt_TYK2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807:SF6">
        <property type="entry name" value="NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18379">
        <property type="entry name" value="FERM_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18377">
        <property type="entry name" value="FERM_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17887">
        <property type="entry name" value="Jak1_Phl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21990">
        <property type="entry name" value="SH2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000636">
        <property type="entry name" value="TyrPK_Jak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01823">
        <property type="entry name" value="JANUSKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01827">
        <property type="entry name" value="YKINASETYK2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 12 16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="FERM" evidence="18">
        <location>
            <begin position="24"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="592"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="896"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="1022"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="902"/>
            <end position="910"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000636-1"/>
        </source>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000636-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1186" mass="136034" checksum="F76CC83C992BD040" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJP3</accession>
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        <submittedName>
            <fullName evidence="9">ADAMTS like 2</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">ADAMTSL2</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KJP3"/>
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    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159447"/>
    <dbReference type="OMA" id="RETNEVC"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:extracellular matrix"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:microfibril binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:extracellular matrix organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:lobar bronchus epithelium development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="entry name" value="ADAMTS like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
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    </dbReference>
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        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
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        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
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        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF147">
        <property type="entry name" value="ADAMTS-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
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            <end position="965"/>
        </location>
    </feature>
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        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="966" mass="108513" checksum="074449094A95D632" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLG5</accession>
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        <submittedName>
            <fullName evidence="11">Calmodulin regulated spectrin associated protein 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="primary">CAMSAP1</name>
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    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The CKK domain binds microtubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CAMSAP1 family.</text>
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    <dbReference type="Ensembl" id="ENSPMRT00000038964.1">
        <property type="protein sequence ID" value="ENSPMRP00000036794.1"/>
        <property type="gene ID" value="ENSPMRG00000023695.1"/>
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    <dbReference type="GeneTree" id="ENSGT00950000182975"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036449">
        <property type="term" value="C:microtubule minus-end"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022604">
        <property type="term" value="P:regulation of cell morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031113">
        <property type="term" value="P:regulation of microtubule polymerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.360:FF:000001">
        <property type="entry name" value="Calmodulin-regulated spectrin-associated protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.360">
        <property type="entry name" value="CKK domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032940">
        <property type="entry name" value="CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031372">
        <property type="entry name" value="CAMSAP_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058042">
        <property type="entry name" value="CAMSAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014797">
        <property type="entry name" value="CKK_CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038209">
        <property type="entry name" value="CKK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595:SF3">
        <property type="entry name" value="CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17095">
        <property type="entry name" value="CAMSAP_CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08683">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25532">
        <property type="entry name" value="CH_CAMSAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01051">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51508">
        <property type="entry name" value="CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="217"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="CKK" evidence="10">
        <location>
            <begin position="1432"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="760"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1307"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="866"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1088"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1343"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1362"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1571" mass="175402" checksum="739B626F3D1435AE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HLU0</accession>
    <name>A0A670HLU0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protein XRP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RP2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NDK family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583641.1">
        <property type="nucleotide sequence ID" value="XM_028727808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HLU0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000303.1">
        <property type="protein sequence ID" value="ENSPMRP00000000290.1"/>
        <property type="gene ID" value="ENSPMRG00000000208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596343"/>
    <dbReference type="KEGG" id="pmua:114596343"/>
    <dbReference type="CTD" id="6102"/>
    <dbReference type="GeneTree" id="ENSGT00940000158262"/>
    <dbReference type="OMA" id="KDYMLTG"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990075">
        <property type="term" value="C:periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000004">
        <property type="entry name" value="Protein XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000007">
        <property type="entry name" value="Protein XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039093">
        <property type="entry name" value="XRP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440:SF0">
        <property type="entry name" value="PROTEIN XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440">
        <property type="entry name" value="XRP2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037947">
        <property type="entry name" value="Protein_XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 12" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="17">
        <location>
            <begin position="37"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="N-myristoyl glycine" evidence="14">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-palmitoyl cysteine" evidence="14">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037947-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037947-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="362" mass="40234" checksum="968AC58EBF6CC42C" modified="2020-06-17" version="1">MGCFFSKRRKQAKEPKPGGGESGDGDVAVPSEAEKQPQYSWDQRAKIDPKDYMFSGLKDETVGRLPGKVAGQQFVIQDCENCNIYIFDHSATITIDDCTNCRIFLGPVKGSVFFRDCKDCKCVVACQQFRTRDCRKMDVFLCCATQPIIESSTGMKFGCFQYYYPELALQLKDAGLSIFNNTWSNIHDFTPVSGENNWSLLAADALVQDHVPLPTAEELKAVRISTDANRSIIPVTQGRRPKHSEESCLAVFFAGDYTTANARKLIDEMTGKGFWLVQTKEVSMKADDARRVFQERATEFIPLVEKGPVVALEFCGDGSVAACQDIVVNVFSGAKVFVSEDKASASREVDSFYNFADMQMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMS1</accession>
    <name>A0A670HMS1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flotillin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FLOT1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Heterooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HMS1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000288.1">
        <property type="protein sequence ID" value="ENSPMRP00000000277.1"/>
        <property type="gene ID" value="ENSPMRG00000000191.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00560000077232"/>
    <dbReference type="OMA" id="AFQIQDI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098691">
        <property type="term" value="C:dopaminergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001931">
        <property type="term" value="C:uropod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070836">
        <property type="term" value="P:caveola assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051580">
        <property type="term" value="P:regulation of neurotransmitter uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000003">
        <property type="entry name" value="Flotillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0967">Endosome</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="202"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="547" mass="60839" checksum="080D049C13345B47" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HR20</accession>
    <name>A0A670HR20_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uroplakin 3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">UPK3A</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028584270.1">
        <property type="nucleotide sequence ID" value="XM_028728437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HR20"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002283.1">
        <property type="protein sequence ID" value="ENSPMRP00000002143.1"/>
        <property type="gene ID" value="ENSPMRG00000001571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596688"/>
    <dbReference type="KEGG" id="pmua:114596688"/>
    <dbReference type="CTD" id="7380"/>
    <dbReference type="GeneTree" id="ENSGT00940000153392"/>
    <dbReference type="OMA" id="EKPFCVF"/>
    <dbReference type="OrthoDB" id="9945328at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120001">
        <property type="term" value="C:apical plasma membrane urothelial plaque"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015840">
        <property type="term" value="P:urea transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060157">
        <property type="term" value="P:urinary bladder development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006833">
        <property type="term" value="P:water transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009952">
        <property type="entry name" value="Uroplakin-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024831">
        <property type="entry name" value="Uroplakin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15446">
        <property type="entry name" value="UROPLAKIN III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15446:SF17">
        <property type="entry name" value="UROPLAKIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07353">
        <property type="entry name" value="Uroplakin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025375377" evidence="3">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="274" mass="30045" checksum="878468013545AB96" modified="2020-06-17" version="1">MWAFWLQLIFCCLWQLCIEGQTLGPQIANPKFATNNPTLTTVALEKPFCVFDGSMLKGAAYEVYLYVMMDSASTSGSFLMDNSSKPLDATFQQTSGGQSGPYKAVVFNVPNCASLPKLSDAADATKAPAILSQYLVRVGDDATCLYDPNFLDACNPPLSQDTAYRFKYVLVDSTAGVMKDQTPWSQPIRTRKLKWSSTIDTWPGRRSGGMIVITSILSVLMFTLVAGFLAATLLTVTTSEETPTEMRYESQTTQQTSPRVLETSESELEVSSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRI6</accession>
    <name>A0A670HRI6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Complement C1q like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">C1QL4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028567854.1">
        <property type="nucleotide sequence ID" value="XM_028712021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HRI6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002525.1">
        <property type="protein sequence ID" value="ENSPMRP00000002374.1"/>
        <property type="gene ID" value="ENSPMRG00000001718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587576"/>
    <dbReference type="KEGG" id="pmua:114587576"/>
    <dbReference type="CTD" id="338761"/>
    <dbReference type="GeneTree" id="ENSGT00940000155969"/>
    <dbReference type="OMA" id="GPTHYEM"/>
    <dbReference type="OrthoDB" id="10070467at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045599">
        <property type="term" value="P:negative regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048147">
        <property type="term" value="P:negative regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000001">
        <property type="entry name" value="Complement C1q B chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF67">
        <property type="entry name" value="COMPLEMENT C1Q-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025598444" evidence="6">
        <location>
            <begin position="16"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="114"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="247" mass="26132" checksum="4A44E9BA0EE0C3B5" modified="2020-06-17" version="1">MVLVLLVAIPLLVHSSKTTSHYEMLGSCRMVCDPYTPQTHGAASAEASQELAVISPPPHVSGGKGDPGRKGKSGIRGPPGPPGPPGPRGPAGEPGRPGPPGPPGPGPGGYIPSFYSPKIAFYAGLRKPHEGYEILRFDDVVTNVGNYYEPSSGKFTCPLPGIYFFTYHVLMRGGDGTSMWADLMKNGQVRASAIAQDADQNYDYASNSVILHLDVGDEVFIKLDGGKVHGGNTNKYSTFSGFIIYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HS51</accession>
    <name>A0A670HS51_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein 75D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HS51"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002181.1">
        <property type="protein sequence ID" value="ENSPMRP00000002050.1"/>
        <property type="gene ID" value="ENSPMRG00000001503.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="OMA" id="HFSYREA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000514">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001005">
        <property type="entry name" value="Zinc finger protein 75A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF152">
        <property type="entry name" value="ZINC FINGER PROTEIN 691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="15">
        <location>
            <begin position="150"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58666" checksum="77D037520CC8FAB1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HT69</accession>
    <name>A0A670HT69_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger protein 740</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF740</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HT69"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002441.1">
        <property type="protein sequence ID" value="ENSPMRP00000002297.1"/>
        <property type="gene ID" value="ENSPMRG00000001660.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159609"/>
    <dbReference type="OMA" id="FICQHCF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000460">
        <property type="entry name" value="Putative zinc finger protein 740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000042">
        <property type="entry name" value="Zinc finger protein 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000230">
        <property type="entry name" value="Zinc finger protein 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF155">
        <property type="entry name" value="EARLY GROWTH RESPONSE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="177" mass="20543" checksum="3E207358E3340E79" modified="2020-06-17" version="1">MSSKWKASLLACEGLSGVCLVPTVASKKMMPKQSPKQGHHRKESEKSRSRKEEEATEGSQPKKSHKKVMVIEQNGSFQLRIPKNFICEHCYGAFRSSYHLKRHILIHTGEKPFECDVCDMRFIQKYHLERHKRVHSGEKPYQCERCLQSFSRTDRLLRHKRMCQGCPSKASDSQLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HU90</accession>
    <name>A0A670HU90_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HU90"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003536.1">
        <property type="protein sequence ID" value="ENSPMRP00000003299.1"/>
        <property type="gene ID" value="ENSPMRG00000002336.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154136"/>
    <dbReference type="OMA" id="HICLMNE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="347" mass="40208" checksum="8D775F55EC5C5639" modified="2020-06-17" version="1">MVQHANALCVQPKWHFPCRGCYQWICNWLTDRTQRVLINGSSSSWRRVTSGVPQGSVLGPVLFNIFINDLDDGLKGILIKFADDTKLGGVANTPEDRITLQNDLDRLENWAKTNKMNFNREKCKVLHLGKKNERHKYKMGDTWLESSTCEKDLGVLVDHKLDMSQQCDAATKKANAILGCINRSIASRSREVIVPLYSALVRPHLEYCVQFWAPQFKKDTDKLERVQRRATKMVKGLEMMPYEERLRELGMFSLEKRRLRGDMIAMFKYIKGCHIEEGERLFSAAPEKRTRSNGSKLQERRFHLNIRKNFLTVRAVRQWNLLPRSVVESPSLEVFKQRLDNHMSGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUU4</accession>
    <name>A0A670HUU4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Solute carrier family 22 member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Organic cation transporter 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">SLC22A3</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-adrenaline(out) = (R)-adrenaline(in)</text>
            <dbReference type="Rhea" id="RHEA:73875"/>
            <dbReference type="ChEBI" id="CHEBI:71406"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(R)-noradrenaline(out) = (R)-noradrenaline(in)</text>
            <dbReference type="Rhea" id="RHEA:73871"/>
            <dbReference type="ChEBI" id="CHEBI:72587"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(R)-salsolinol(in) = (R)-salsolinol(out)</text>
            <dbReference type="Rhea" id="RHEA:74791"/>
            <dbReference type="ChEBI" id="CHEBI:194082"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L-proline diketopiperazine(out)</text>
            <dbReference type="Rhea" id="RHEA:74787"/>
            <dbReference type="ChEBI" id="CHEBI:90039"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>agmatine(out) = agmatine(in)</text>
            <dbReference type="Rhea" id="RHEA:72131"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dopamine(out) = dopamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73863"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>guanidine(out) = guanidine(in)</text>
            <dbReference type="Rhea" id="RHEA:73883"/>
            <dbReference type="ChEBI" id="CHEBI:30087"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>histamine(out) = histamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73879"/>
            <dbReference type="ChEBI" id="CHEBI:58432"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>serotonin(out) = serotonin(in)</text>
            <dbReference type="Rhea" id="RHEA:73867"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>spermidine(in) = spermidine(out)</text>
            <dbReference type="Rhea" id="RHEA:35039"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tyramine(in) = tyramine(out)</text>
            <dbReference type="Rhea" id="RHEA:74783"/>
            <dbReference type="ChEBI" id="CHEBI:327995"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Basolateral cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028579664.1">
        <property type="nucleotide sequence ID" value="XM_028723831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HUU4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003247.1">
        <property type="protein sequence ID" value="ENSPMRP00000003030.1"/>
        <property type="gene ID" value="ENSPMRG00000002162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594309"/>
    <dbReference type="KEGG" id="pmua:114594309"/>
    <dbReference type="CTD" id="6581"/>
    <dbReference type="GeneTree" id="ENSGT00940000160810"/>
    <dbReference type="OMA" id="NYWCRIP"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015651">
        <property type="term" value="F:quaternary ammonium group transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019534">
        <property type="term" value="F:toxin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990748">
        <property type="term" value="P:cellular detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090494">
        <property type="term" value="P:dopamine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048241">
        <property type="term" value="P:epinephrine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051625">
        <property type="term" value="P:epinephrine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051615">
        <property type="term" value="P:histamine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015718">
        <property type="term" value="P:monocarboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051620">
        <property type="term" value="P:norepinephrine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032098">
        <property type="term" value="P:regulation of appetite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051610">
        <property type="term" value="P:serotonin uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000165">
        <property type="entry name" value="Solute carrier family 22 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004749">
        <property type="entry name" value="Orgcat_transp/SVOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00898">
        <property type="entry name" value="2A0119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="29">
        <location>
            <begin position="103"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00037001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00072456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00079877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="556" mass="62739" checksum="97C8DFAD5CB16ED9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWJ2</accession>
    <name>A0A670HWJ2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neurexin 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HWJ2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003711.1">
        <property type="protein sequence ID" value="ENSPMRP00000003462.1"/>
        <property type="gene ID" value="ENSPMRG00000002442.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154618"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="Laminin_G"/>
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        <property type="entry name" value="Neurexin-related_CASP"/>
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    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025359307" description="Neurexin 3" evidence="3">
        <location>
            <begin position="28"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="27"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29929" checksum="6216C0DE88326FA8" modified="2020-06-17" version="1">MGFTFRSASFTLKLSLVLGSLLSLCLGLEFMGLPSQWARYLRWDASTRSDLSFQLKTNVSAGLLLYFDDGGVCDFLCLSLVDGRIQLRFSVDCAEATVVTDKQVNDSNLHFLMVSRNHLRTVLVLDGEAKPGEVRPQRQYMNIVSDLFVGGVPSDIRPAALTLDSVLSEPPFKGFILDLKYGNSEPQLLGHQGVRLDMEGLCTENPCENGGTCFLLDGEPQCDCSATGYIGKLCSEGKRSFILLLGFCSNHIAVQACNYHLPLKKIEIWTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWV1</accession>
    <name>A0A670HWV1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="13">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-specific succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="13">A-SCS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Succinyl-CoA synthetase beta-A chain</fullName>
            <shortName evidence="13">SCS-betaA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">SUCLA2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028559844.1">
        <property type="nucleotide sequence ID" value="XM_028704011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HWV1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003856.1">
        <property type="protein sequence ID" value="ENSPMRP00000003597.1"/>
        <property type="gene ID" value="ENSPMRG00000002516.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582758"/>
    <dbReference type="CTD" id="8803"/>
    <dbReference type="GeneTree" id="ENSGT00390000010170"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000040">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03220">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034723">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 13" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="62"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="381"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="464" mass="50377" checksum="96D55456C2D48310" modified="2020-06-17" version="1">MAASMMGARAAAAAAAKQLLGWGCAERSAAAKVFSGRQGLFPSYVFQVQQRRSLSLHEYLSMELLKEAGISVPYGLVAKTPEEAYNIAKEIGTKDLVVKAQVLAGGRGKGTFEGGLKGGVKIVFSPEEAREISSRMIGKKLYTKQTGEKGRICNQVFICERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIAKEPVDIVEGIQKEQAIRLAKKMGFPANLVNEAADNMIKIYNLFIKFDATMVEINPMVEDSTGIVMCMDAKINFDSNSAYRQQKIFDLQDWTQEDQRDRDAAKADLNYIGLDGSIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVQQVTEAFKLITSDKKVQAILVNIFGGIMRCDVISQGIIMAVKDLEIKIPIVVRLQGTRVDDAKALITASGLKILACDDLDEAAKMVVKLSEIVTLAKEAQVDVKFQLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXG0</accession>
    <name>A0A670HXG0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tripartite motif containing 39</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ohanin/vespryn family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HXG0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004667.1">
        <property type="protein sequence ID" value="ENSPMRP00000004373.1"/>
        <property type="gene ID" value="ENSPMRG00000002984.1"/>
    </dbReference>
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    <dbReference type="OMA" id="NEEEWAV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Bbox2_TRIM7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16594">
        <property type="entry name" value="RING-HC_TRIM7-like_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPRY_PRY_TRIM7_like"/>
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    </dbReference>
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        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
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        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
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        <location>
            <begin position="243"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="191"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="48647" checksum="FC1CA33A0C8F229C" modified="2020-06-17" version="1">MAATRGPVRDLREGTTCSICLDYFRDPVIIHECGHNFCRTCLIQYWEKSEGEASCPQCRERVEQSSITRNQQLANFVEIAKKFNHPQEKEEGEGKGRVCEKHQEPLKLFCKEDQSPICVVCYVSKEHKSHEVIPLEEASQEYKVGKGSGSFLGEQTRCLILAHCSLLSTSLLQKQTGAEREKMVAEFRRMHQFLEEQEKRILAQMAEVEKEIAAQREEHLARLSRELSSLDSLIREMEEKLQEPATELLQVRPHPDVREWKNITLDPDTANPLLILSEDRKSVREGEECQNLPDNPERFDTCGYVLGCEGFTSGRHFWEVIVGREEKWGVGVAIKFVKRNGWPTEGIWGLGKMEGEYQYFFPHEVFVPSEEPKRIRVTLNCEAGRVSFFDADTAALLHSFSAASLSGENLQPFFYVSKKGNLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ57</accession>
    <name>A0A670HZ57_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HZ57"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004723.1">
        <property type="protein sequence ID" value="ENSPMRP00000004427.1"/>
        <property type="gene ID" value="ENSPMRG00000003026.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287023"/>
    <dbReference type="OMA" id="FLIMSFK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="150" mass="16915" checksum="7B439CF4041F7A99" modified="2020-06-17" version="1">MDRFDLLAVHGTLKSLLQHHNSKASILWRSAFFMVQLSLPYMTTGKTIALTIRTFVMSLLFKMLSRFVIAFLPRSRRLLISWLLSPSAVIMEPKEVKSLTASISSPSICQSGVQVPVITSLLFSQTWFRLWLNPVSPTSALLFTFTDSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZB8</accession>
    <name>A0A670HZB8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 272</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <source>
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    </evidence>
    <sequence length="300" mass="32647" checksum="83EE2A4F5BF86710" modified="2020-06-17" version="1">MEWYQQRAPPHRCFTLISHGYFFHWLSSVPSRWKDWTQFCPQPPEPENGGYICHPSPCKEPLTSDSVIEYLCEEGYLLKGDYKYLTCKNGKWNPDMEVTCRLSQDKGSPPSVGVPTLSIVASTASSVALILLLVVLFVLLQPKLKSFHHSRRDQGVSGDQVSIVVDGVQVALPSYEEAVYGSAGNCIPPSDSRVQIVLSEGAGQSGAREMQQPPDQVGHNCFAGEDEIPGRSGLCEAGSSHHSEAVLVHQATTSSWVAGASCSRPGHKEAPDSESSDVQSLLSLASSEEYTDDIPLLKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1E8</accession>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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            <authorList>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EPCAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I383"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006251.1">
        <property type="protein sequence ID" value="ENSPMRP00000005877.1"/>
        <property type="gene ID" value="ENSPMRG00000003988.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018245"/>
    <dbReference type="OMA" id="YDPDCDH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000008">
        <property type="entry name" value="tumor-associated calcium signal transducer 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049420">
        <property type="entry name" value="EPCAM-Trop-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043406">
        <property type="entry name" value="EPCAM/Trop-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041630">
        <property type="entry name" value="EpCAM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14168">
        <property type="entry name" value="TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14168:SF5">
        <property type="entry name" value="TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21283">
        <property type="entry name" value="EPCAM-Trop-2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18635">
        <property type="entry name" value="EpCAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025343601" evidence="11">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="12">
        <location>
            <begin position="60"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="311" mass="35139" checksum="DC05D09926EBCC98" modified="2020-06-17" version="1">VLPPSSAFGAALVLMLVATSATQNDCFCPTNNLASCSSESGSCICTARGSNQRLDCSTLTPKCLLIKAEIKTKRGRSFPRPEHGFVDNDGLYNPECDAMGFFKARQCNQTDTCWCVNSAGVRRTDKGDLNMRCNELVRTSWIYIEMKHKERKTPLSESEVANSFRQLIENRYMLHPKFITAVEYKEPLIHIDLKQNISEKSYRDVDIADVAYYFEKDIQGKPIFPPDNMFGLYVNDEPLDIEEILVYYVDDKPPEFSMQRLTAGIIAVVVVVVLAIVIGITVLVVTRRRKTGKYEKVEIKEMGEMRKGQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3G0</accession>
    <name>A0A670I3G0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complement component C8 beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Complement component 8 subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">C8B</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8B, together with C8A and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Heterotrimer of 3 chains: alpha (C8A), beta (C8B) and gamma (C8G); the alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC), composed of complement C5b, C6, C7, C8A, C8B, C8G and multiple copies of the pore-forming subunit C9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complement C6/C7/C8/C9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I3G0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006372.1">
        <property type="protein sequence ID" value="ENSPMRP00000005990.1"/>
        <property type="gene ID" value="ENSPMRG00000004063.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160247"/>
    <dbReference type="OMA" id="KYYAGAC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005579">
        <property type="term" value="C:membrane attack complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006957">
        <property type="term" value="P:complement activation, alternative pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160257">
        <property type="term" value="P:complement activation, GZMK pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000082">
        <property type="entry name" value="Complement component C8 beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000069">
        <property type="entry name" value="complement component C8 beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048831">
        <property type="entry name" value="C8A_B_C6_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001862">
        <property type="entry name" value="MAC_perforin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020863">
        <property type="entry name" value="MACPF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742">
        <property type="entry name" value="COMPLEMENT COMPONENT C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742:SF5">
        <property type="entry name" value="COMPLEMENT COMPONENT C8 BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21195">
        <property type="entry name" value="EGF_C8A_B_C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00764">
        <property type="entry name" value="COMPLEMENTC9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00279">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0179">Complement alternate pathway</keyword>
    <keyword evidence="16" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="14" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="19 26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0473">Membrane attack complex</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="12 27" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="22" id="KW-1053">Target membrane</keyword>
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    <sequence length="570" mass="64973" checksum="FD4F14F13915F795" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I402</accession>
    <name>A0A670I402_PODMU</name>
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            <fullName evidence="10">Phosphodiesterase</fullName>
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        <name evidence="13" type="primary">PDE7B</name>
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        <name type="scientific">Podarcis muralis</name>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <reaction evidence="1">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <name>a divalent metal cation</name>
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        <text evidence="10">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
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    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.</text>
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    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
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        <location>
            <begin position="149"/>
            <end position="472"/>
        </location>
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        <location>
            <begin position="472"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <begin position="487"/>
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        </location>
    </feature>
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            <position position="225"/>
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        <location>
            <begin position="225"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>AMP</name>
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            <name>Zn(2+)</name>
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            <label>2</label>
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        <ligand>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I405</accession>
    <name>A0A670I405_PODMU</name>
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        <submittedName>
            <fullName evidence="9">T-box transcription factor 18</fullName>
        </submittedName>
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        <name evidence="9" type="primary">TBX18</name>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028722901.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A670I405"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007027.1">
        <property type="protein sequence ID" value="ENSPMRP00000006594.1"/>
        <property type="gene ID" value="ENSPMRG00000004464.1"/>
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    <dbReference type="GeneID" id="114593919"/>
    <dbReference type="KEGG" id="pmua:114593919"/>
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    <dbReference type="GeneTree" id="ENSGT00940000155566"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="T-box_TBX15_18_22-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
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        <property type="entry name" value="T-box_DNA-bd"/>
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        <property type="entry name" value="T-box_sf"/>
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        <property type="entry name" value="TF_T-box"/>
    </dbReference>
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        <property type="entry name" value="TF_T-box_CS"/>
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        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF20">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TBOX"/>
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        <property type="entry name" value="TBOX"/>
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        <property type="entry name" value="p53-like transcription factors"/>
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        <location>
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            <end position="433"/>
        </location>
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        <location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Ensembl" id="ENSPMRP00000006594.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    <sequence length="710" mass="76129" checksum="78BC04A16606341F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I427</accession>
    <name>A0A670I427_PODMU</name>
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        <submittedName>
            <fullName evidence="10">Ras homolog family member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RHOA</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
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        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
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    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000006619.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:small GTPase-mediated signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RASTRNSFRMNG"/>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="193" mass="21782" checksum="C4CFCDC31FF858BC" modified="2020-06-17" version="1">MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I454</accession>
    <name>A0A670I454_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trophoblast glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TPBG</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cys-rich_flank_reg_C"/>
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    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
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        <property type="entry name" value="Wnt_signaling_inhibitor"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24364:SF17">
        <property type="entry name" value="TROPHOBLAST GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="LRRNT"/>
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        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LRR"/>
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    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        <location>
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            <end position="394"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="6">
        <location>
            <begin position="46"/>
            <end position="80"/>
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        <location>
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            <end position="317"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="394" mass="43668" checksum="34A156F0477FA299" modified="2020-06-17" version="1">MLGCSLWGSAPPTPTGEKRGAGWLEPLLLLLVVVLSGWVLAQQTADCPGTCDCSEAARTVKCINRNLTEVPVGLPRYVRNLFLMGNHIQNVSSASFPPETLLELSSLNLSGNRLQWVEAGTFAGLPSLKQLDLSDNALLELSPMALGNTSSPLEELNLRNSLYNNSYVTAVAQLLQQEAFLNLKRLDLSENTLLYLPQGMFAALHSLQHLDLHNNSLVSLHGVTLENLRQLQSVNLSGNALKRLRNSTLLQLRGLPQLTSLNLTHNAWVCDCGIEDMVSWLKESDLVEAKSSLKCSYPKGMENRSLVAIDFSELSCPEPTDNQTQLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMYNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4J3</accession>
    <name>A0A670I4J3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Semaphorin 3F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SEMA3F</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028574469.1">
        <property type="nucleotide sequence ID" value="XM_028718636.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574470.1">
        <property type="nucleotide sequence ID" value="XM_028718637.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574471.1">
        <property type="nucleotide sequence ID" value="XM_028718638.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574472.1">
        <property type="nucleotide sequence ID" value="XM_028718639.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574473.1">
        <property type="nucleotide sequence ID" value="XM_028718640.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574474.1">
        <property type="nucleotide sequence ID" value="XM_028718641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I4J3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007272.1">
        <property type="protein sequence ID" value="ENSPMRP00000006816.1"/>
        <property type="gene ID" value="ENSPMRG00000004623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591514"/>
    <dbReference type="KEGG" id="pmua:114591514"/>
    <dbReference type="CTD" id="6405"/>
    <dbReference type="GeneTree" id="ENSGT00940000156703"/>
    <dbReference type="OMA" id="HQDYIFY"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048846">
        <property type="term" value="P:axon extension involved in axon guidance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021785">
        <property type="term" value="P:branchiomotor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021612">
        <property type="term" value="P:facial nerve structural organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048843">
        <property type="term" value="P:negative regulation of axon extension involved in axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901166">
        <property type="term" value="P:neural crest cell migration involved in autonomic nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061549">
        <property type="term" value="P:sympathetic ganglion development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097490">
        <property type="term" value="P:sympathetic neuron projection extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097491">
        <property type="term" value="P:sympathetic neuron projection guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021637">
        <property type="term" value="P:trigeminal nerve structural organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036486">
        <property type="term" value="P:ventral trunk neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05871">
        <property type="entry name" value="Ig_Sema3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11254">
        <property type="entry name" value="Sema_3F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000030">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000001">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF27">
        <property type="entry name" value="SEMAPHORIN-3F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025559207" evidence="10">
        <location>
            <begin position="23"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="12">
        <location>
            <begin position="31"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="617"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="769"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="792" mass="89794" checksum="29282E8F7878F083" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6J4</accession>
    <name>A0A670I6J4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DZIP C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I6J4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007864.1">
        <property type="protein sequence ID" value="ENSPMRP00000007347.1"/>
        <property type="gene ID" value="ENSPMRG00000004972.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156862"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032714">
        <property type="entry name" value="DZIP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF5">
        <property type="entry name" value="CILIUM ASSEMBLY PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13815">
        <property type="entry name" value="Dzip-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="210"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="346" mass="40320" checksum="25FCA40B58201622" modified="2020-06-17" version="1">SSYEGSRPPHLQRARRAARSSVPAFQFRPRLDPPDWRRLSAVDVERVAAEVDVAALQEHLAHVAFCDAGRERCPRCQAPADPLLLRLLRLAQLSLEYLLHCQDYLSAQLRATQELLRAADAHRDLLAKDVARGAQEARLLREECKRRKKIIGTQQMMLQAGAACHQCQFCDKAFMNYSFLHSHLQRRHSCVAQNNKKKFLLIDQKQKVQTGQLQEEINKLKEQLQLTRSQLEAEQHAHMVKLSKEYDEHRSKEEEIRQLFHKWKEEEKDKLASELEKMKEMFMKEFKELTAKNTELENHLLEVQKSNNHLKSNLGTLKDSYEFPEEKHQSAVDQQEAVQAFEKQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I760</accession>
    <name>A0A670I760_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Keratinocyte associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KRTCAP3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I760"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008087.1">
        <property type="protein sequence ID" value="ENSPMRP00000007551.1"/>
        <property type="gene ID" value="ENSPMRG00000005089.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004700"/>
    <dbReference type="OMA" id="CKWQENV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020977">
        <property type="entry name" value="Beta-casein-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31258">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31258:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12304">
        <property type="entry name" value="BCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="221" mass="22935" checksum="19714AF9DFDAE01F" modified="2020-06-17" version="1">LARCSDAGPRARRLVRSGISLVVLGHLNLVLGAIVHGSVLRHVARPARTITSEYAVANVIAVASGLLSIAAGVVAILVSRSRSPPWLRWVLLAAALLNALVSGACCAGLLLAVSLTVANGGRFLLAGCNRSALATDARTVRTDECPFDTTRIFDTALALWLPSLVMAAVEAGLSAWCCVASFSLSGHGPSSYKVALVRGNLLLAQLAPLCKGGGREMLLLY</sequence>
</entry>
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    <accession>A0A670I7I1</accession>
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        </submittedName>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
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                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000008165.1">
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        <property type="gene ID" value="ENSPMRG00000005156.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114596714"/>
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    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        </location>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="265" mass="29851" checksum="88721546F21E6E31" modified="2020-06-17" version="1">MGQQACDQQGIARKPHICCVPAPSAPNLCKGSSWLGKAQPKKPCPSAGLRRGDATAVGSGEEGCSEARETAADGSQNKTGEGPCASEPVSVREASKSAASDVNLDREERRHYSRLRTAFTMEQLRRLESTFRRQPYLKQWERQDLAAELHLTEEQVKNWFQNRRMKLKRQLQDYRRRLWPSSPGCLICQPRIPPSLLPYMPNPALWPNPPGCKYQPFQNPPYPFPLPGLPYHFPTQFSGNSTEEYKMDSSKQTFPTPALGYGMAW</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
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        </source>
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            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <location evidence="1">Secreted</location>
        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
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            <begin position="85"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="221" mass="23857" checksum="4AD2EF92187B9A7B" modified="2020-06-17" version="1">MAGRRLWWRRRRGALAEPAGGYSCVAVAAAALALLLLELPGGSPAVPAQNDTEPIVLEGKCLVVCDSSPSADGAITSSLGISVRSGSAKVAFSATRSTNHEPSEMSNRTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQVSLMQNGYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLERGNLMGGWKYSTFSGFLVFPL</sequence>
</entry>
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    <accession>A0A670I9S7</accession>
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            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Carneiro M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF102">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="198" mass="23198" checksum="4E02DA8A6AF3AC56" modified="2020-06-17" version="1">MLKKNKKKFTCPLCDRSFTEKWALNNHMKLHTGEKPYKCSWPTCHYSFLTVSAMKDHYRTHTGEKSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCDECNFASTTQSHLTRHKRVHTGEKPYRCPWCDYRSNCAENIRKHILHTGKHEGVKMYNCPKCEYGTNIPVEFRNHLKELHPDIENPDLAYLHAGKNIFMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I9T6</accession>
    <name>A0A670I9T6_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">Beta-defensin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
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                <person name="Afonso S."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I9T6"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Antimicrobial Peptide, Beta-defensin 2, Chain A"/>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00711"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="61" mass="6939" checksum="12F3C622BF18FCE0" modified="2020-06-17" version="1">PLLLLLLLLLLLLLLLLICTLHICSDLECQQQKGLCFPGRCSRPWRSIGTCNVVLHHCCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IC76</accession>
    <name>A0A670IC76_PODMU</name>
    <protein>
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            <fullName evidence="6">Cytidine monophosphate-N-acetylneuraminic acid hydroxylase</fullName>
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        </alternativeName>
        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="15">CMP-NeuAc hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114601366</name>
    </gene>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O</text>
            <dbReference type="Rhea" id="RHEA:16145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:58376"/>
            <dbReference type="EC" id="1.14.18.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylneuraminate metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CMP-Neu5Ac hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670IC76"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009851.1">
        <property type="protein sequence ID" value="ENSPMRP00000009227.1"/>
        <property type="gene ID" value="ENSPMRG00000006202.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000009862.1">
        <property type="protein sequence ID" value="ENSPMRP00000009238.1"/>
        <property type="gene ID" value="ENSPMRG00000006202.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010830"/>
    <dbReference type="OMA" id="WKSFLMC"/>
    <dbReference type="UniPathway" id="UPA00628"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030338">
        <property type="term" value="F:CMP-N-acetylneuraminate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046381">
        <property type="term" value="P:CMP-N-acetylneuraminate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006054">
        <property type="term" value="P:N-acetylneuraminate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03473">
        <property type="entry name" value="Rieske_CMP_Neu5Ac_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000025">
        <property type="entry name" value="Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037339">
        <property type="entry name" value="CMP-Neu5Ac_hydroxylase_Rieske"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027033">
        <property type="entry name" value="Cnh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46522">
        <property type="entry name" value="CYTIDINE MONOPHOSPHATE-N-ACETYLNEURAMINIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46522:SF1">
        <property type="entry name" value="INACTIVE CYTIDINE MONOPHOSPHATE-N-ACETYLNEURAMINIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13483">
        <property type="entry name" value="Lactamase_B_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="19">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="589" mass="68135" checksum="8B08405CE59C718E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDF6</accession>
    <name>A0A670IDF6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IDF6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010342.1">
        <property type="protein sequence ID" value="ENSPMRP00000009699.1"/>
        <property type="gene ID" value="ENSPMRG00000006502.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="CCECGRN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000806">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002026">
        <property type="entry name" value="Zinc finger protein 160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000540">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000990">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF73">
        <property type="entry name" value="ZINC FINGER PROTEIN 572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="108"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="12">
        <source>
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    <evidence type="ECO:0000259" key="13">
        <source>
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        <source>
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    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="684" mass="77214" checksum="BA2723D2A3AAB2A6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IE53</accession>
    <name>A0A670IE53_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dynein axonemal heavy chain 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DNAH5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="2">Belongs to the dynein heavy chain family.</text>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1949"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2228"/>
            <end position="2383"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2557"/>
            <end position="2705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="881"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3176"/>
            <end position="3213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3399"/>
            <end position="3454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3690"/>
            <end position="3717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="899"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="4578" mass="524311" checksum="BF4F0E9F5ED700BC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGI9</accession>
    <name>A0A670IGI9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114598062</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028587546.1">
        <property type="nucleotide sequence ID" value="XM_028731713.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028587547.1">
        <property type="nucleotide sequence ID" value="XM_028731714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IGI9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011156.1">
        <property type="protein sequence ID" value="ENSPMRP00000010462.1"/>
        <property type="gene ID" value="ENSPMRG00000006959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598062"/>
    <dbReference type="KEGG" id="pmua:114598062"/>
    <dbReference type="GeneTree" id="ENSGT00390000012141"/>
    <dbReference type="OMA" id="FWWKVLA"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051652">
        <property type="entry name" value="MDM2_MDM4_MUL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022170">
        <property type="entry name" value="MUL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183">
        <property type="entry name" value="MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183:SF6">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12483">
        <property type="entry name" value="GIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="350" mass="38773" checksum="EFC91D492BE39DE5" modified="2020-06-17" version="1">MDTLPLTPGELVCLGSSLAFSGLFYYLHRKKAKVVTKIQEAPKLQVNDSLPSILSATGSSCLGYVAIEGVVQPVETALTSPYHEELQGVIERLVLKEHRLIWNSLARSWTDSERVVLEQVHTVPFVLASPSGKASGQVCVESPLHAVELPVETVYERFQQTSHGFKDLLSHYLSGEKPKGFLETEEMLLVGSSLTGIGELALHRDGSLHLQPPADGTGYFLRLGDWEAILADLRSVSSFWKWASLLCGLAAAAVILRALCRAYHRHKVHQEQEAQQQEFENLRRHQSAGLDLSEEPPENACVICLTSLRECVLLPCGHVCCCFRCFQAFPNRTCPICRSPIDRVVPLYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIZ0</accession>
    <name>A0A670IIZ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloprotease TIKI</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">TRAB domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TRABD2B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="13">Divalent metal cations. Mn(2+) or Co(2+).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TIKI family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028589380.1">
        <property type="nucleotide sequence ID" value="XM_028733547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IIZ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012306.1">
        <property type="protein sequence ID" value="ENSPMRP00000011521.1"/>
        <property type="gene ID" value="ENSPMRG00000007718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599028"/>
    <dbReference type="KEGG" id="pmua:114599028"/>
    <dbReference type="CTD" id="388630"/>
    <dbReference type="GeneTree" id="ENSGT00940000161273"/>
    <dbReference type="OMA" id="WHKKQYK"/>
    <dbReference type="OrthoDB" id="10040378at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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</entry>
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                <person name="Marsik P."/>
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                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="3">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
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</entry>
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        </citation>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1158" mass="128233" checksum="69D2C8C27DA73D45" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IND0</accession>
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    </protein>
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    </gene>
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        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
            <dbReference type="EC" id="2.1.1.321"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.321" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028595398.1">
        <property type="nucleotide sequence ID" value="XM_028739565.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028595399.1">
        <property type="nucleotide sequence ID" value="XM_028739566.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028595400.1">
        <property type="nucleotide sequence ID" value="XM_028739567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IND0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014390.1">
        <property type="protein sequence ID" value="ENSPMRP00000013475.1"/>
        <property type="gene ID" value="ENSPMRG00000009018.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601918"/>
    <dbReference type="KEGG" id="pmua:114601918"/>
    <dbReference type="CTD" id="54496"/>
    <dbReference type="GeneTree" id="ENSGT00940000156879"/>
    <dbReference type="OMA" id="CHHDEYS"/>
    <dbReference type="OrthoDB" id="412876at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044020">
        <property type="term" value="F:histone H4R3 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071514">
        <property type="term" value="P:genomic imprinting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000010">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000004">
        <property type="entry name" value="Protein arginine N-methyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000070">
        <property type="entry name" value="Protein arginine N-methyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000071">
        <property type="entry name" value="Protein arginine N-methyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014644">
        <property type="entry name" value="MeTrfase_PRMT7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF4">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036946">
        <property type="entry name" value="Arg_N-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="2 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 13 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="176"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="514"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR036946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="690" mass="77907" checksum="5244048C4E8458BC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IP67</accession>
    <name>A0A670IP67_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 8"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="90" mass="10342" checksum="339298FC97A2013C" modified="2020-06-17" version="1">MPAIVYQGSELPLPAGWEEARDYDRCIFYINHNTWQTLWIDPPGQDYKATDISCVGDELPLGWEIVYDQQIGVDYSGTSQDECLARQKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQ69</accession>
    <name>A0A670IQ69_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SPATA18</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028600095.1">
        <property type="nucleotide sequence ID" value="XM_028744262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IQ69"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014587.1">
        <property type="protein sequence ID" value="ENSPMRP00000013654.1"/>
        <property type="gene ID" value="ENSPMRG00000009153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604279"/>
    <dbReference type="CTD" id="132671"/>
    <dbReference type="GeneTree" id="ENSGT00390000013532"/>
    <dbReference type="OMA" id="DQNLNIC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901612">
        <property type="term" value="F:cardiolipin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900210">
        <property type="term" value="P:positive regulation of cardiolipin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF0">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="15">
        <location>
            <begin position="252"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="449"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="118"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="497" mass="56742" checksum="1E0847D32BAA39A9" modified="2020-06-17" version="1">MADSLRRLINNETCRILQEKLENWYKDYHINSCDQNLTRCCEIMELNSMIQGQLFTILNKTSQEGGHYAGVDTIKSRLLPWLGTCFSSHTCGSSSHLQESREKDRWMKELACTRDQEIHQLEKELSSTRLQLSFVQQDLAEAQVALEDTKAKSATTLLAAEDEIVQLKAELKASRVKEECALKNLDRMSDYEQQLQTLKDEIAILGAQKSLLQNRLALSRSPSPRSIRSRSPSPLPKRSSSPGRARLTNASRHARLVERFSDIYAQERLDAQSLLRSYVDDLEMVQRIIYTAVVESFRAAKMAFRQFKMRVRKTLSLSYSGPESLEDMAMDYIVRQEDLYDVQASVCEVIRAMNINPKISFPPETDFIMISGLIRELCRVAFSMQTLDPPLDISFGTDGELFSEYKYRRSYDSEFTAPLVAYHVWPALMEEDTVLVKGEAVTRRGAVWSQRGRSRSRSRSRSRSCSLRPLSPSAGHSRHLRSRSRSSSPLRSGSPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQG9</accession>
    <name>A0A670IQG9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IQG9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015367.1">
        <property type="protein sequence ID" value="ENSPMRP00000014388.1"/>
        <property type="gene ID" value="ENSPMRG00000009590.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000204219"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042269">
        <property type="term" value="P:regulation of natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051527">
        <property type="entry name" value="KLR_subfamily_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46784">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46784:SF1">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12069" checksum="1A34434F171AC242" modified="2020-06-17" version="1">HCFRSNPTEQEKTGVLHLPCGSTHSSFVFPSTDNSPCKVCPMQWQLHRDKCYWPSDYMKTWDESQHDCSTRASQLLVIQDKEELVRGQLHMHSTNDHAFHKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRM0</accession>
    <name>A0A670IRM0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Receptor-type tyrosine-protein phosphatase alpha</fullName>
            <ecNumber evidence="4 18">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PTPRA</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4 18"/>
    <dbReference type="RefSeq" id="XP_028599989.1">
        <property type="nucleotide sequence ID" value="XM_028744156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IRM0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015670.1">
        <property type="protein sequence ID" value="ENSPMRP00000014670.1"/>
        <property type="gene ID" value="ENSPMRG00000009798.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604229"/>
    <dbReference type="KEGG" id="pmua:114604229"/>
    <dbReference type="CTD" id="5786"/>
    <dbReference type="GeneTree" id="ENSGT00940000159585"/>
    <dbReference type="OMA" id="TESWEGN"/>
    <dbReference type="OrthoDB" id="6144703at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
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        <location>
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        </location>
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            <begin position="32"/>
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        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
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    <sequence length="828" mass="92640" checksum="F036325A1FC74DC6" modified="2020-06-17" version="1"> </sequence>
</entry>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
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                <person name="Salvi D."/>
                <person name="Soler L."/>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Rubin C.J."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="entry name" value="TNFR_5"/>
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        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5"/>
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    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
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        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
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            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
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        <location>
            <begin position="316"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="405"/>
            <end position="458"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="78"/>
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        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="212"/>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="458" mass="49245" checksum="DD208E05647DFDC5" modified="2020-06-17" version="1">ALGVPSDSAIPELDGPFGRSSVKPRPWGNGEGRLPPAPSVRRGGTPAPPPKRAALGTLKRERERPRREPGFPFPGKREPRWLSLPAGSLWLPCSLEGAGGLPPCGSLWADGNRTPKGGLSGGQIPHLSGAQRFPRQAAPRCALTSALLLAPERKLWVPLGLWLWGAGGRDEDDEDGAETNPPPAVQCLALELRGPSCSATEYQEGGRCCQKCGPGTKVQALCSESSETRCVACEAQHFQAGWTKEKHCVPQAYCDENAGFLVFTEGDATRNVVCRCRTGTHCSSRECLTCRVNRECPAGEGVQRQANHLNDTVCMACPPGSFSNISSATTRCQPWSSCEAGKMVRLANGTHSSDVVCGVLPTQPPQEEARRTHVLLVVPLVALLGLLAGALFLLHRHRMRQDLWKPPLNQPEAPLDHGRPQPEEIEDPPFPTQETLLGGQPVAQEDGKESRLAEQAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISI7</accession>
    <name>A0A670ISI7_PODMU</name>
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        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Exosome component 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EXOSC9</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028743468.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000014459.1"/>
        <property type="gene ID" value="ENSPMRG00000009633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603938"/>
    <dbReference type="CTD" id="5393"/>
    <dbReference type="GeneTree" id="ENSGT00950000183130"/>
    <dbReference type="OMA" id="GPQFENG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
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        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nuclear mRNA surveillance"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
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        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="32"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="13">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="435" mass="48659" checksum="8146FC76D031CB87" modified="2020-06-17" version="1">MKETPLSNCEKRFLLRAIEERKRLDGRQCYDYRNLRISFGTDYGCCIVELGKTRVLGQVSCELVAPKPNRATEGILFFNLELSPMASPAFEPGRQSELLIKLNRLLERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHNGNIIDAASIAAIVALCHFRRPDVSVQGEEVTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPSEQEERVMDGLLVIAMNKHREICTIQSSGGIMLLKDQVLRCSKITGVKVAEITELIQKALENDQKVRKEGGKFGFAESIPSQKITAFKIDQAPIDTNDVQEQAEEIISKAFPPSEVLAKPILWASGTAQIGEGQESSWGDFEESEKEEEEDEVTPDEPITVEDQSMETGDTGVRTRSQKDETIVLSDSEEEDVVILEPEIALSRPESSPKQDINKKTAGKKKKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISQ2</accession>
    <name>A0A670ISQ2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Collagenase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114595296</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028581432.1">
        <property type="nucleotide sequence ID" value="XM_028725599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ISQ2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015186.1">
        <property type="protein sequence ID" value="ENSPMRP00000014217.1"/>
        <property type="gene ID" value="ENSPMRG00000009481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595296"/>
    <dbReference type="KEGG" id="pmua:114595296"/>
    <dbReference type="GeneTree" id="ENSGT00940000154907"/>
    <dbReference type="OMA" id="FFPTYHK"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000007">
        <property type="entry name" value="Collagenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF165">
        <property type="entry name" value="COLLAGENASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0177">Collagen degradation</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="9 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025575321" evidence="18">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="19">
        <location>
            <begin position="98"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="17">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="167"/>
        </location>
        <ligand>
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            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
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            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
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    </evidence>
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    <evidence type="ECO:0000256" key="18">
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    <evidence type="ECO:0000259" key="19">
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            <dbReference type="SMART" id="SM00235"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    <sequence length="258" mass="28951" checksum="C5135ACB6C36BE7D" modified="2020-06-17" version="1">MNGALICMALFLPYSLAVPIAHDPEAQSVEDMKFVEAYLDKYFPSSSSHLKSGGQSIEEKLRQMQSFFHLTVTGKMNQETMATMEQPRCGVSDISEKSAVRWGKTLLTYRINNYTPDMPKSKVEEAIAKAFKVWSDVTPLQFRRTSRPADIEIWFATGAHGDGSPFDGRGGTLAHAYFPGRGIGGDAHFDDSERFSEFNREINLFLVAAHEFGHSLGLSHSNVRGSLMFPSYSFVNPNNFNLPNNDRQRIQRLYGLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUR6</accession>
    <name>A0A670IUR6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Breast carcinoma amplified sequence 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IUR6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017027.1">
        <property type="protein sequence ID" value="ENSPMRP00000015948.1"/>
        <property type="gene ID" value="ENSPMRG00000010652.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006790"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024857">
        <property type="entry name" value="Cappuccino"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16230:SF5">
        <property type="entry name" value="BREAST CARCINOMA-AMPLIFIED SEQUENCE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16230">
        <property type="entry name" value="CAPPUCCINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38714" checksum="469E5602ACE50B87" modified="2020-06-17" version="1">MTLGVPSESANLCFLRPRWLLHPGPDRSRLPTASGERQAPHPCEGEEAKSRAMRGAAAAALPLWAGGATVPRRRRQGAPRARPAAPGKREPLRIRPTALGCGGVPEPGPEKPLPAASGPSRLPATAMSAAAASERGEASASSTTLSPSAEAGGGHGEPQLRAEEAAAEEEEREARQFALYLAPEAGREGREEVKEIEESIEEMLIRLDEFCGMTDLIRSNTSQLLDEAIPLIKAKVIEMNSIYTKVDKLEAFVKMAGHHVSFLEEQVLEAEKAHAIFPYTVQKLFGSVATPSFKKRKCVVFGGSVAQSVLETRAKRPCTKPRVPADTDCQVDHKQQIENKQRPSFIDMSLLATSYRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IV93</accession>
    <name>A0A670IV93_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Achaete-scute family bHLH transcription factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ASCL4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IV93"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016463.1">
        <property type="protein sequence ID" value="ENSPMRP00000015414.1"/>
        <property type="gene ID" value="ENSPMRG00000010274.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162902"/>
    <dbReference type="OMA" id="YIPFPGY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19746">
        <property type="entry name" value="bHLH_TS_ASCL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000038">
        <property type="entry name" value="achaete-scute homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="186" mass="21169" checksum="6A2BA6DAAB3AE557" modified="2020-06-17" version="1">LEQRKPERLTLPLRIFASLGNGHPNPHGLPLREPFGVPFHFDPAYWDHQAYGGYSGRFSYLPFSGYVGVYDYSFEPAFIRKRNERERQRVRCVNEGYTRLRDHLPKEFADKRLSKVETLRAAITYIKHLQNLLDHQPLGTIPKIAVPAAEAAGASDLSLRRECNSDGESKTSLASSPYSEFEEVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVY1</accession>
    <name>A0A670IVY1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphodiesterase</fullName>
            <ecNumber evidence="10">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PDE4B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25278"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028589008.1">
        <property type="nucleotide sequence ID" value="XM_028733175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IVY1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017201.1">
        <property type="protein sequence ID" value="ENSPMRP00000016115.1"/>
        <property type="gene ID" value="ENSPMRG00000010762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598885"/>
    <dbReference type="KEGG" id="pmua:114598885"/>
    <dbReference type="CTD" id="5142"/>
    <dbReference type="GeneTree" id="ENSGT00940000155190"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071872">
        <property type="term" value="P:cellular response to epinephrine stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071878">
        <property type="term" value="P:negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901898">
        <property type="term" value="P:negative regulation of relaxation of cardiac muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001780">
        <property type="term" value="P:neutrophil homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032743">
        <property type="term" value="P:positive regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032729">
        <property type="term" value="P:positive regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902514">
        <property type="term" value="P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086004">
        <property type="term" value="P:regulation of cardiac muscle cell contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040844">
        <property type="entry name" value="PDE4_UCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0114">cAMP</keyword>
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        <location>
            <begin position="326"/>
            <end position="655"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="708"/>
            <end position="732"/>
        </location>
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        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
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            <end position="154"/>
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            <begin position="402"/>
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    <sequence length="732" mass="82984" checksum="CDB7904FD14EC811" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Lepidosauria</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
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        </recommendedName>
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        <name evidence="14" type="primary">ATG4C</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
                <person name="Uller T."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028589068.1">
        <property type="nucleotide sequence ID" value="XM_028733235.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028589069.1">
        <property type="nucleotide sequence ID" value="XM_028733236.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000017019.1"/>
        <property type="gene ID" value="ENSPMRG00000011290.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114598902"/>
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    <dbReference type="GeneTree" id="ENSGT00530000063000"/>
    <dbReference type="OMA" id="KMAGDWY"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF38">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="77"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    <sequence length="459" mass="52508" checksum="A4F354D423CB5D75" modified="2020-06-17" version="1">MEAAGTDEVEKIKSKFMSAWHNMKYSWVLKTKTYFSRNSPVFLLGKCYHFKTEESSDTSPNGSNYDITDEGISRNVEEFRKDFISRIWLTYREEFPQIKGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRDWTWPDAFVIENSDSESWTSHTVKKLTASLEASRTGEKEFRNQSSHHKQAPGGNWGNRERRDEHFHRKIISWFGDSPLANFGLHRLTEYGNKSGKIAGDWYGPAVVAHLLRKAVEESRDPELQGITVYVAQDCTVYKSDVIDTQCSFADSEKSDAKSVIILIPVRLGGERTNMEYLEFVKGILSLEYCIGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSVKDFPLESFHCPSPKKMSFKKMDPSCTIGLYCPNVQAFERASEEITKILKSSSKENYPLFTFVNGHSRDYDFLMSPVLEERTLFSEDENKKLKCFSTEDFVLL</sequence>
</entry>
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                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        </subcellularLocation>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J375</accession>
    <name>A0A670J375_PODMU</name>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF3">
        <property type="entry name" value="INACTIVE UFM1-SPECIFIC PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="43"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="242" mass="26802" checksum="C717BE457A6DCC1C" modified="2020-06-17" version="1">MNNDSFSLCPPQACLSSLLQRMPLLSDVHLELPLPDPPPHRLALVSGSYRYYHYGCDGVDDRGWGCGYRTLQTVCSWLPPSVEKTLPRPVPSLQEIQNALVEIGDKPASFAGSRDWMGTVEAALCLDHFYSVPGKVVHVPHGRELERELEALHAHFQGGGGPVMMGGDRDNSSKGLLGVCSGPEGRHHLLVLDPHYYGQAGSLTREELQAQRWVHWRELALFEAGSFYNLCFPQFRAKGCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3J4</accession>
    <name>A0A670J3J4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">m7GpppN-mRNA hydrolase</fullName>
            <ecNumber evidence="13">3.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">mRNA-decapping enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DCP2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63714"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="EC" id="3.6.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67485"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.62" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028605302.1">
        <property type="nucleotide sequence ID" value="XM_028749469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J3J4"/>
    <dbReference type="SMR" id="A0A670J3J4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019262.1">
        <property type="protein sequence ID" value="ENSPMRP00000018104.1"/>
        <property type="gene ID" value="ENSPMRG00000011931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606871"/>
    <dbReference type="KEGG" id="pmua:114606871"/>
    <dbReference type="CTD" id="167227"/>
    <dbReference type="GeneTree" id="ENSGT00390000018878"/>
    <dbReference type="OMA" id="YICKEDY"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904872">
        <property type="term" value="P:regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000001">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="19">
        <location>
            <begin position="95"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="244"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="417" mass="48217" checksum="19AA65D7F31D8A00" modified="2020-06-17" version="1">METKRAEIPSGVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVQRVLDEWKEYKMGVPTYGAIILDESLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYINKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIDKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRYGDSSDSDNGFSSTSSSTPPKPNMEKMRSKLHYSQPVVTDGPSGEQWTKQRQLQQQKPYNNHFETSDALKLKNPRSNGRKQYQDTPNQKKKTNGVQSQPAKQNQTLKCEKKLHPRRLQDNFETEAAYDMCCVNEDQLLEHGQSGPCNGHCKITFSSRAFLSFKFDHDAIMRSFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4K3</accession>
    <name>A0A670J4K3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
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                <person name="Sabatino S.J."/>
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                <person name="Marsik P."/>
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                <person name="Salvi D."/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <location>
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</entry>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J9I6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021579.1">
        <property type="protein sequence ID" value="ENSPMRP00000020319.1"/>
        <property type="gene ID" value="ENSPMRG00000013235.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234712"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="458"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="912" mass="104649" checksum="6877C9647F8E93D6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC21</accession>
    <name>A0A670JC21_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mRNA decay activator protein ZFP36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Zinc finger protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114603103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028597682.1">
        <property type="nucleotide sequence ID" value="XM_028741849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JC21"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023367.1">
        <property type="protein sequence ID" value="ENSPMRP00000021998.1"/>
        <property type="gene ID" value="ENSPMRG00000014311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603103"/>
    <dbReference type="KEGG" id="pmua:114603103"/>
    <dbReference type="GeneTree" id="ENSGT00940000161584"/>
    <dbReference type="OMA" id="NPHFYAI"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061158">
        <property type="term" value="P:3'-UTR-mediated mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900153">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF53">
        <property type="entry name" value="MRNA DECAY ACTIVATOR PROTEIN ZFP36L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="310" mass="33429" checksum="4D6DB5CD936D9FFD" modified="2020-06-17" version="1">MPSYFLSPFQELDDALCKTFLSLNLNEDDNSPDARRFLRFQRTFSACPVALSASGFEGTGCAVHPADTVTPHATAAGPSDPAWPLQQPWGRDSELPPTSLQRIPFRADRSTSLIEGCCRGDTKPPSSRYKTELCRTFEESGVCKYGAKCQFAHGVAELRGLSRHPKYKTEPCRTFHTSGICPYGARCHFIHNAEERRVPPPRAPLPTRHCPAADPLPVGPRLPETSFPRDALSQPTLACPLRAAGATRGSLSCPFAFPALLTLQKSLSADSLSDQEDSGSSGGSSGSESPGLGPLGRRLPIFSQISVSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JCV9</accession>
    <name>A0A670JCV9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANKRD10</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028583955.1">
        <property type="nucleotide sequence ID" value="XM_028728122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JCV9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022775.1">
        <property type="protein sequence ID" value="ENSPMRP00000021459.1"/>
        <property type="gene ID" value="ENSPMRG00000013931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596466"/>
    <dbReference type="KEGG" id="pmua:114596466"/>
    <dbReference type="CTD" id="55608"/>
    <dbReference type="GeneTree" id="ENSGT00940000156564"/>
    <dbReference type="OMA" id="ILNGVHQ"/>
    <dbReference type="OrthoDB" id="5402602at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF12">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="411" mass="43971" checksum="8C0E6031E3B7D726" modified="2020-06-17" version="1">MSLGSGPEAGFSSEELLTLRFPLHRACRDGDLPALCSLLQSAPRENLAAEDSFYGWTPIHWAAHFGKLDCLMQLVRAGATVNACTTRHAQTPAHIAAFGGHPQCLIWLIQSGANINKQDYGGETPIHKAARSGSMESISALVAHGAQIDLRNASGQTAADLAQTQGFQECAQLLLNLQNCPLNHFYSNGTLNGAHQNTSPSLLGRGINRKRSFEDMNSVGMKKARTEGQSFGGLISVINGGTEDDADNMHVDREFPVISDMNCSNSILNALTNGHIVNGHLDFTSPAQLNGMSARHEECLTLIAPNALASANKHTVSVGNSVEEPEKVVNGSSEMCGSLHLNGSPSSLVSSRPSWVDDLGDTLHYGHYHGFGDTAESIPELNSVVEHSNSVKVAQKYDNTVLGTMYLYHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJK4</accession>
    <name>A0A670JJK4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FERM domain containing 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FRMD4B</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JJK4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025205.1">
        <property type="protein sequence ID" value="ENSPMRP00000023749.1"/>
        <property type="gene ID" value="ENSPMRG00000015388.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230354"/>
    <dbReference type="OMA" id="RAPHNPY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13191">
        <property type="entry name" value="FERM_C_FRMD4A_FRMD4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17200">
        <property type="entry name" value="FERM_F1_FRMD4B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FERM domain containing 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000019">
        <property type="entry name" value="FERM domain containing 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000022">
        <property type="entry name" value="Putative FERM domain-containing protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021774">
        <property type="entry name" value="CUPID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047176">
        <property type="entry name" value="FRMD4A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041785">
        <property type="entry name" value="FRMD4A/B_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079:SF1">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="59"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="576"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="655"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="732"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1050" mass="119279" checksum="CB1BB92E8FCAE13C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLF9</accession>
    <name>A0A670JLF9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP-Gly domain containing linker protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JLF9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025821.1">
        <property type="protein sequence ID" value="ENSPMRP00000024344.1"/>
        <property type="gene ID" value="ENSPMRG00000015722.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159426"/>
    <dbReference type="OMA" id="HMIESSD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000001">
        <property type="entry name" value="Putative CAP-Gly domain-containing linker protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF10">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="834" mass="94416" checksum="21F49F4D507C8F3D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNT7</accession>
    <name>A0A670JNT7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DOCKER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JNT7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027147.1">
        <property type="protein sequence ID" value="ENSPMRP00000025575.1"/>
        <property type="gene ID" value="ENSPMRG00000016566.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157469"/>
    <dbReference type="OMA" id="ACKERTM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060997">
        <property type="term" value="P:dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11699">
        <property type="entry name" value="DHR2_DOCK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF71">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="3">
        <location>
            <begin position="384"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="889" mass="101616" checksum="CB7108872084F141" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPE9</accession>
    <name>A0A670JPE9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein kinase 17A</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DAP kinase-related apoptosis-inducing protein kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">STK17A</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028606864.1">
        <property type="nucleotide sequence ID" value="XM_028751031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JPE9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026909.1">
        <property type="protein sequence ID" value="ENSPMRP00000025349.1"/>
        <property type="gene ID" value="ENSPMRG00000016409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607646"/>
    <dbReference type="KEGG" id="pmua:114607646"/>
    <dbReference type="CTD" id="9263"/>
    <dbReference type="GeneTree" id="ENSGT00940000154014"/>
    <dbReference type="OMA" id="AWNKSTE"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000271">
        <property type="term" value="P:positive regulation of fibroblast apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000369">
        <property type="entry name" value="Serine/threonine kinase 17a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000175">
        <property type="entry name" value="Serine/threonine-protein kinase 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="46"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="398" mass="45681" checksum="6FFF4012733A24B2" modified="2020-06-17" version="1">MSPEEKPPPPRRSRGGRAPPQPRRGGLLTEIRTRILTEPFQERYSLSPGRELGRGKFAVVKKCVKKETEKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQRNRWVINLHEVYETPTEIILVLEYAAGGEIFDQCVAERDDAFKEKEVKRLMRQILEGVSFLHRNNVVHLDLKPQNILLTSESPLGDVRIVDFGLSRVMKNSEELREIMGTPEYVAPEILSYDPISTATDMWSIGVLAYVMLTGVSPFLGNDKQETFLNISQMNVNYSEDFDLISEFAVDFIKSLLVKKPEERATADECLVHSWLAQIDVPDTIYWIKNTEEANTVVVNEEAFTSENSTDEEKTEESLVSEELIVVASYTLGQCRQSEKDKIVEQKTISKRFKFEEPLLQEIPGEFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPP8</accession>
    <name>A0A670JPP8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glial cell line-derived neurotrophic factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GDNF</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TGF-beta family. GDNF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605090.1">
        <property type="nucleotide sequence ID" value="XM_028749257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JPP8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026472.1">
        <property type="protein sequence ID" value="ENSPMRP00000024952.1"/>
        <property type="gene ID" value="ENSPMRG00000016124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606733"/>
    <dbReference type="KEGG" id="pmua:114606733"/>
    <dbReference type="CTD" id="2668"/>
    <dbReference type="GeneTree" id="ENSGT00950000182993"/>
    <dbReference type="OMA" id="DYSDQFD"/>
    <dbReference type="OrthoDB" id="9950038at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030116">
        <property type="term" value="F:glial cell-derived neurotrophic factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001658">
        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021516">
        <property type="term" value="P:dorsal spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048484">
        <property type="term" value="P:enteric nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035860">
        <property type="term" value="P:glial cell-derived neurotrophic factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003337">
        <property type="term" value="P:mesenchymal to epithelial transition involved in metanephros morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001240">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001759">
        <property type="term" value="P:organ induction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030432">
        <property type="term" value="P:peristalsis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090190">
        <property type="term" value="P:positive regulation of branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072108">
        <property type="term" value="P:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072107">
        <property type="term" value="P:positive regulation of ureteric bud formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021784">
        <property type="term" value="P:postganglionic parasympathetic fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001941">
        <property type="term" value="P:postsynaptic membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051584">
        <property type="term" value="P:regulation of dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001260">
        <property type="term" value="P:regulation of semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048485">
        <property type="term" value="P:sympathetic nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060676">
        <property type="term" value="P:ureteric bud formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000015">
        <property type="entry name" value="Glial cell line-derived neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043401">
        <property type="entry name" value="GDNF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173">
        <property type="entry name" value="GDNF SUBFAMILY OF TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173:SF1">
        <property type="entry name" value="GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025581175" description="Glial cell line-derived neurotrophic factor" evidence="12">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="13">
        <location>
            <begin position="108"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="216" mass="24519" checksum="EEBD7F99F9E5E1AD" modified="2020-06-17" version="1">MKLWDVVAVCMLLLNTISTFPLPDGQTRSVLEGAEDDHTSNRLLTPYAGQMDSNISEDYPKRLGDVEDFIQATIKILKRSPDKPTPYSSKRERNRQRAAKNNNNSSSRKGRRDPKGRNRDCVLTEMHLNVTDLGLGYNTKEELIFRYCSGSCESAVTVYDQILNNLTQNRKLASDKIRPQPCCRPIAYDDDVSFLDDDLSTYHILKKHSAKRCGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQV9</accession>
    <name>A0A670JQV9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-terminal asparagine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NTAN1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JQV9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027471.1">
        <property type="protein sequence ID" value="ENSPMRP00000025884.1"/>
        <property type="gene ID" value="ENSPMRG00000016754.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016730"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026750">
        <property type="entry name" value="NTAN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498">
        <property type="entry name" value="N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14736">
        <property type="entry name" value="N_Asn_amidohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="327" mass="35666" checksum="219972EA8C5FA9F4" modified="2020-06-17" version="1">MQKGIALPTFASGPAHRCYAAPRRLTLEESGPRAGIDATPSPLTPEGSPDPPPTPPRPLPNAPEDYISQRPLQPGLASPSWRGAQLRVSGRKFRGCCAGRFPEMPLLVNGERVDLSQPTRELIYTFPELEEQAKILRGQPAQSVGPKGLLYVQQREFAVTTPKDASVSILGSDDATTCHLVVLRHTGSGAICLTHCDGSDTETEVLLITNAVKVLSPNTECGRLEVHLIGGFSDDRHLSQRLTNQLLRAFDRLQDNVHLVTFCVTELNDRQEKGKHLPFIYGIAANVKTGEIFHATFPDKGPDVDLRSASILTGAKVRRHVFQFSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQY2</accession>
    <name>A0A670JQY2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sphingomyelin phosphodiesterase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SMPD4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028565450.1">
        <property type="nucleotide sequence ID" value="XM_028709617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JQY2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029113.1">
        <property type="protein sequence ID" value="ENSPMRP00000027448.1"/>
        <property type="gene ID" value="ENSPMRG00000017692.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586318"/>
    <dbReference type="KEGG" id="pmua:114586318"/>
    <dbReference type="CTD" id="55627"/>
    <dbReference type="GeneTree" id="ENSGT00390000006044"/>
    <dbReference type="OMA" id="EERGKIH"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050290">
        <property type="term" value="F:sphingomyelin phosphodiesterase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024129">
        <property type="entry name" value="Sphingomy_SMPD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988:SF6">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14724">
        <property type="entry name" value="mit_SMPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="810"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="842" mass="96287" checksum="CF1634F268AD566A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRV6</accession>
    <name>A0A670JRV6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Reticulon 4 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RTN4R</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the Nogo receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566672.1">
        <property type="nucleotide sequence ID" value="XM_028710839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JRV6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027293.1">
        <property type="protein sequence ID" value="ENSPMRP00000025712.1"/>
        <property type="gene ID" value="ENSPMRG00000016653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586959"/>
    <dbReference type="KEGG" id="pmua:114586959"/>
    <dbReference type="CTD" id="65078"/>
    <dbReference type="GeneTree" id="ENSGT00940000160711"/>
    <dbReference type="OMA" id="RSQCRMA"/>
    <dbReference type="OrthoDB" id="546383at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905573">
        <property type="term" value="F:ganglioside GM1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905576">
        <property type="term" value="F:ganglioside GT1b binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000018">
        <property type="entry name" value="Reticulon 4 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF174">
        <property type="entry name" value="RETICULON-4 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025503185" evidence="17">
        <location>
            <begin position="27"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="361"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="484" mass="54109" checksum="5113D8526230E52B" modified="2020-06-17" version="1">MKRAIAEGSKLLILVLCLNFPSEAESCPGACVCYSEPKITISCQQQGLGAIPTEIPIQTQRIFLHSNKITVIRSTSFTSCRNMSILWIHSNNISLIEPGAFYGLDKLEELDLSDNTNLRSINPSTFQGLVHLHTLHLDRCGLLELSTGLFRGLFSLQYLYLQDNSLQNLLDDTFLDLANLTYLFLHGNRIKSLSENVFRGLINLDRLLLHQNRVSVIHRRAFHDLGKVMTLYLFNNNLTVLTGETMAPLVSLQYLRLNGNQWVCDCQARSLWDWFKQFKGSSSELECHLPAHLAGRDLKRLQSADLEGCVDSFNQIRTSVFSTKTRTGKLPTADPPLSPHDGGRKCCQPEMDKSFIYEAKAKAGPSSHSSRASSNNPLKDKENIAKTKPQVETDPSKNSSNKQINDSPFGTFPSAVDPPLTNLKPEFLGPIEPSTVPTKRRQGCSKKNKSRSQCRIAQPTQSTTSRLIPSLSITLLVWSLFWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSB5</accession>
    <name>A0A670JSB5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GON-4-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GON-4 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Found in a complex with YY1, SIN3A and HDAC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000028010.1">
        <property type="protein sequence ID" value="ENSPMRP00000026404.1"/>
        <property type="gene ID" value="ENSPMRG00000017076.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016256"/>
    <dbReference type="OMA" id="HRNYKDC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12202">
        <property type="entry name" value="CASP8AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000191">
        <property type="entry name" value="GON-4-like protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000006">
        <property type="entry name" value="GON-4-like protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049257">
        <property type="entry name" value="Gon4l/CASP8AP2_myb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052435">
        <property type="entry name" value="YY1-Transcr_Regul"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088:SF3">
        <property type="entry name" value="GON-4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088">
        <property type="entry name" value="YY1 ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21227">
        <property type="entry name" value="Myb_DNA-binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="301"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="874"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1053"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1156"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1733"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1796"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2008"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1055"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1241"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1327"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1376"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1398"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1431"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1512"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1804"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1826"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2031"/>
            <end position="2041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="2041" mass="223947" checksum="4F600F853564BFD3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSP7</accession>
    <name>A0A670JSP7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670JSP7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028144.1">
        <property type="protein sequence ID" value="ENSPMRP00000026529.1"/>
        <property type="gene ID" value="ENSPMRG00000017156.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154988"/>
    <dbReference type="OMA" id="QANCEDE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF30">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="321" mass="36840" checksum="359099ABCA5E82DD" modified="2020-06-17" version="1">MIFTARQLQEKCREQNQPLYMVFIDLTKVFNTVNHNALWTVLLKIGCADKYVNIIRLLHDNMTAIIADNNGSQSEPFTVESGVKQGCVIAPILFIIFIATILHFVEGKLPTGVEIIYRTDGKLFNLSRLKAKSKVTVTSIIELQYADDNVVCAHSEDDLQTILNIFAETYKKLGLSLNIQKTKVLHQQVQNNPSAVPQIQLNGVTLENVDHFSYLGSYLSTRGNNDAEIRHHLSSASAAFSQLKCRVFEDLDIHRETKMLVYKPIVLPTLLYAFETWTTYKRHLQLFERFHQRCLRKFLHITWEDRRTNISVLEEAKITSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTQ7</accession>
    <name>A0A670JTQ7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sperm-associated antigen 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SPAG7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JTQ7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030255.1">
        <property type="protein sequence ID" value="ENSPMRP00000028523.1"/>
        <property type="gene ID" value="ENSPMRG00000018420.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001520"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02636">
        <property type="entry name" value="R3H_sperm-antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034068">
        <property type="entry name" value="R3H_sperm-antigen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017330">
        <property type="entry name" value="SPAG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13498">
        <property type="entry name" value="SPERM ASSOCIATED ANTIGEN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13498:SF3">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037943">
        <property type="entry name" value="Sperm-assoc_antigen_PAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="47"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="235" mass="26702" checksum="4BB16DD9CA8AE26E" modified="2020-06-17" version="1">MAELDLLGSILSSMEPPPALGDREAKRAKEQTAQLKKLQEQEKRQKVEFRKRMEKEVSDFIQDSSQTKKKFRPMNKIERSILHDVVEVAGLTSFSFGDEEESRYVMIFKKEFAPSDEELDAYRRGEEWDPQQAEEKRRLKELAQRQAEEEALKGPTVVNPNTDYKDKYSHLIGKVAAKDAAHTMEANKAYGCGESAGGGWLPQTRRDIRSKQPGLAPCPSRALPAVRRVISLKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JU92</accession>
    <name>A0A670JU92_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PTPRB</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029736.1">
        <property type="protein sequence ID" value="ENSPMRP00000028036.1"/>
        <property type="gene ID" value="ENSPMRG00000018091.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156088"/>
    <dbReference type="OMA" id="HLRTGQC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14617">
        <property type="entry name" value="R-PTPc-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000369">
        <property type="entry name" value="Protein tyrosine phosphatase, receptor type B"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000009">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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    </evidence>
    <sequence length="1481" mass="167191" checksum="0ACD5BAD3879EDBC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXC5</accession>
    <name>A0A670JXC5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane BAX inhibitor motif containing 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114603326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028742220.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028742227.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028598069.1">
        <property type="nucleotide sequence ID" value="XM_028742236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JXC5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031757.1">
        <property type="protein sequence ID" value="ENSPMRP00000029948.1"/>
        <property type="gene ID" value="ENSPMRG00000019360.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603326"/>
    <dbReference type="GeneTree" id="ENSGT01050000244890"/>
    <dbReference type="OMA" id="FHVADWD"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF35">
        <property type="entry name" value="PROTEIN LIFEGUARD 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029948.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34544" checksum="7996DE70D6CF50FC" modified="2020-06-17" version="1">MSRPSAPPPGYDDRNPLYPPPAGGYPAGYPGGYPQPQPQPPPYSGGYGQPGGYSQPGGYPQPVPIMPTVPMGFGDVYGGGAAGEDGTFTTADWDDKKVRHVFIRKVYTIISLQLLITVGIIAVFTFVEPVSSFVRRNVAVYYVSYAVFFVTYLVLACCEGPRRRFPWNLILLTIFTLAMGFMTGTIASMYSTKAVIICMIITAIVAIVVTIFCFQTKVDFTSCTGLFCVLGIVVMVTGIITAIVLAFKYVYWLHMLYAGIGAIAFTLFLAYDTQLLLGNRKHAMSPEEYVYGALKIYTDIVYIFTFLLQIVGSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K029</accession>
    <name>A0A670K029_PODMU</name>
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        <submittedName>
            <fullName evidence="13">Zinc finger CCCH-type containing 12B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZC3H12B</name>
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    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
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    <dbReference type="RefSeq" id="XP_028570403.1">
        <property type="nucleotide sequence ID" value="XM_028714570.1"/>
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        <property type="nucleotide sequence ID" value="XM_028714571.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028714572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K029"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032011.1">
        <property type="protein sequence ID" value="ENSPMRP00000030191.1"/>
        <property type="gene ID" value="ENSPMRG00000019520.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114588867"/>
    <dbReference type="CTD" id="340554"/>
    <dbReference type="GeneTree" id="ENSGT00940000159316"/>
    <dbReference type="OMA" id="WDPLPCT"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18729">
        <property type="entry name" value="PIN_Zc3h12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZC3H12A isoform 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040757">
        <property type="entry name" value="Regnase_1/ZC3H12_C"/>
    </dbReference>
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        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
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        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF27">
        <property type="entry name" value="RIBONUCLEASE ZC3H12B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18561">
        <property type="entry name" value="Regnase_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
            <begin position="151"/>
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        </location>
    </feature>
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        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
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            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="832" mass="93106" checksum="C0637CA864ECD82C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0J2</accession>
    <name>A0A670K0J2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13186"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A670K0J2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032939.1">
        <property type="protein sequence ID" value="ENSPMRP00000031053.1"/>
        <property type="gene ID" value="ENSPMRG00000020123.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009083"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000260">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000003">
        <property type="entry name" value="porphobilinogen deaminase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="17">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="325" mass="35809" checksum="03FB47C51C9E228B" modified="2020-06-17" version="1">TDSVVQMLQERHPHLCFEIVAMSTTGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTSLPPGFTIGAICKRESPYDAVVFHPKHAGKSLHSLPEKSVIGTSSLRRAAQLKRKFPHLEFRDIRGNLNTRLKKLDEKEDFSAIVLAAAGLRRMGWDSRIGQGLCPCSSSFLQGALAVEVRARDQEILDMVSVLHDGETVLRCIAERAFMKHLEGGCSVPVAVNTVLKDFQLYLTGAVYSLDGSESLRETMQASMNYFPHENEDGPNDDIQHVGITAKNFSQSAQVAAEKLGIQVAELLLSRGAKHILNVARQLNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K1H8</accession>
    <name>A0A670K1H8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycophorin C (Gerbich blood group)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GYPC</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K1H8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032467.1">
        <property type="protein sequence ID" value="ENSPMRP00000030611.1"/>
        <property type="gene ID" value="ENSPMRG00000019819.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000049102"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042192">
        <property type="entry name" value="Glycophorin-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47614">
        <property type="entry name" value="GLYCOPHORIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47614:SF2">
        <property type="entry name" value="GLYCOPHORIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Neurexin/syndecan/glycophorin C" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="114" mass="12757" checksum="DF2FC47FD3EABCE9" modified="2020-06-17" version="1">MGAATGLPKCNYGGGLILLFLVFVLYCLYFFLNPVFIITMSKPLSDVLLCVIAAVAFVLICLLVVMLRYMYRHKGTYHTNEAKGTEFAESADAALKNDPTLQEAMDESRKEYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2P8</accession>
    <name>A0A670K2P8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <location>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="183" mass="20803" checksum="5B6647DF501A9933" modified="2020-06-17" version="1">MTFACSRFLFMFLYFLDTFSRAVENPAYQVKGILGGSVLFPANISQGITVEKMEWDFYPQRGGLGFWLGEFSHGKLEHPSPTDRFGQRLDMVNETTLKVKDLELDDSGIYNARIWFMKSQFQEQSFSLTVYEPVPTPQMLHQEISSNLEGCNVTLQCQTPGRSDTQGLLGKRESLQGLRKQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3W9</accession>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
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        <property type="term" value="C:axonemal A tubule inner sheath"/>
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    </dbReference>
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        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING FAMILY MEMBER B"/>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="160" mass="18632" checksum="CDE52EE24C67466D" modified="2020-06-17" version="1">MVDVTPQKMNKDAQMRASINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKGNCRLISGIVNVLTELSHKYKAYGSECLYICILKTHHLSVSFHLHSSSFKHCILDPVPSRTKMSISQKIYSTFWHIIISCLKFLFKKKFIFLSLYYIYTQAMLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K496</accession>
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        <submittedName>
            <fullName evidence="23">Contactin associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CNTNAP1</name>
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    <organism evidence="23 24">
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        <lineage>
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            <taxon>Episquamata</taxon>
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            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Paranodal septate junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028702727.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000030990.1"/>
        <property type="gene ID" value="ENSPMRG00000020081.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114581981"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:paranodal junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033270">
        <property type="term" value="C:paranode region of axon"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022010">
        <property type="term" value="P:central nervous system myelination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:myelination in peripheral nervous system"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098529">
        <property type="term" value="P:neuromuscular junction development, skeletal muscle fiber"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0050884">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:protein localization to juxtaparanode region of axon"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000005">
        <property type="entry name" value="Contactin associated protein-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.120.1000">
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
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    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF43">
        <property type="entry name" value="CONTACTIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5025451973" evidence="18">
        <location>
            <begin position="22"/>
            <end position="1334"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1240"/>
            <end position="1264"/>
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    </feature>
    <feature type="domain" description="F5/8 type C" evidence="19">
        <location>
            <begin position="28"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="177"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="364"/>
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    </feature>
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        <location>
            <begin position="547"/>
            <end position="584"/>
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    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="22">
        <location>
            <begin position="583"/>
            <end position="637"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="782"/>
            <end position="957"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="958"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="1019"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1280"/>
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    </feature>
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        <location>
            <begin position="1290"/>
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        </location>
    </feature>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51406"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1334" mass="151489" checksum="D5BFB592EA912C52" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K568</accession>
    <name>A0A670K568_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex I-B18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase B18 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NDUFB7</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028573106.1">
        <property type="nucleotide sequence ID" value="XM_028717273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K568"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034651.1">
        <property type="protein sequence ID" value="ENSPMRP00000032678.1"/>
        <property type="gene ID" value="ENSPMRG00000021174.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114590789"/>
    <dbReference type="KEGG" id="pmua:114590789"/>
    <dbReference type="CTD" id="4713"/>
    <dbReference type="GeneTree" id="ENSGT00390000018759"/>
    <dbReference type="OMA" id="FVYQCAH"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="129" mass="15549" checksum="F2F52CFF267E6038" modified="2020-06-17" version="1">MGAHLARRYLWDAEVEPDPVKMPTFDPHFGFPEERKERVMIATEQQMNEAQLPLDMRDYCAHYFLKWAKCKRDKFPNIFACKHERHDWDYCEHLDYVMRMKEFERERRLLARKKRIEQKAKAAAAASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5A5</accession>
    <name>A0A670K5A5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">16S rRNA (uridine(1369)-2'-O)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">16S rRNA [Um1369] 2'-O-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein ftsJ homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MRM2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3. Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins; methyltransferase activity is not required for this function. Essential for mitochondrial respiratory function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uridine(1369) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methyluridine(1369) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47764"/>
            <dbReference type="Rhea" id="RHEA-COMP:11903"/>
            <dbReference type="Rhea" id="RHEA-COMP:11904"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K5A5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031851.1">
        <property type="protein sequence ID" value="ENSPMRP00000030037.1"/>
        <property type="gene ID" value="ENSPMRG00000019422.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111241"/>
    <dbReference type="OMA" id="HRQTDHL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000129">
        <property type="entry name" value="Mitochondrial rRNA methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="16">
        <location>
            <begin position="46"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="241" mass="27319" checksum="8EFD74A532BF3B6C" modified="2020-06-17" version="1">MPNLLLQHQRIHTAVQFLKSKTGAEHRWLERHFSDPYVKKAKKEHYRCRSVYKLLEVDDKYRILCPGLRVIDCGTAPGAWAQVAVQRVNAMGSDPDAPIGFVLGVDLLHVFPLEGAVLLPRADITDPVTQKKIQEVLPKGMVDVILSDMAPNATGIRQLDHHKLIHLCLSLLDLAQHILEPGGTMLCKYWDGGESHLLQKRLMQDFQEVKTLKLQASRKESAERYYLAQSYKRAAHRASKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5Y8</accession>
    <name>A0A670K5Y8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calglandulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114592951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the cellular control mechanism of the secretion of toxins from the gland into the venom.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028577187.1">
        <property type="nucleotide sequence ID" value="XM_028721354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K5Y8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032935.1">
        <property type="protein sequence ID" value="ENSPMRP00000031049.1"/>
        <property type="gene ID" value="ENSPMRG00000020127.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592951"/>
    <dbReference type="GeneTree" id="ENSGT01030000234570"/>
    <dbReference type="OMA" id="HDQASTN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000019">
        <property type="entry name" value="Myosin light chain 1 skeletal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000056">
        <property type="entry name" value="Myosin light chain 1 skeletal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF7">
        <property type="entry name" value="SIMILAR TO MYOSIN, LIGHT POLYPEPTIDE 6, ALKALI, SMOOTH MUSCLE AND NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="3" id="KW-0518">Myosin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="151" mass="16889" checksum="5A2DE932F6577FA5" modified="2020-06-17" version="1">MCDFSEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVMKVLGNPKSDEMNAKTLSFEQFLPMMQTIAKNKDQGCFEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHILSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6X3</accession>
    <name>A0A670K6X3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 500-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114581858</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028558363.1">
        <property type="nucleotide sequence ID" value="XM_028702530.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028558364.1">
        <property type="nucleotide sequence ID" value="XM_028702531.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028558365.1">
        <property type="nucleotide sequence ID" value="XM_028702532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K6X3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034500.1">
        <property type="protein sequence ID" value="ENSPMRP00000032536.1"/>
        <property type="gene ID" value="ENSPMRG00000021079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581858"/>
    <dbReference type="KEGG" id="pmua:114581858"/>
    <dbReference type="GeneTree" id="ENSGT00940000159965"/>
    <dbReference type="OMA" id="PMEVESH"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002239">
        <property type="entry name" value="Zinc finger protein 226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001005">
        <property type="entry name" value="Zinc finger protein 75A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF423">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="14">
        <location>
            <begin position="184"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="351"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="558" mass="62666" checksum="D20A8681F470FC35" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7K4</accession>
    <name>A0A670K7K4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger CCHC domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TRAMP-like complex RNA-binding factor ZCCHC7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZCCHC7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028567327.1">
        <property type="nucleotide sequence ID" value="XM_028711494.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028567328.1">
        <property type="nucleotide sequence ID" value="XM_028711495.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028567329.1">
        <property type="nucleotide sequence ID" value="XM_028711496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K7K4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034742.1">
        <property type="protein sequence ID" value="ENSPMRP00000032766.1"/>
        <property type="gene ID" value="ENSPMRG00000021234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587372"/>
    <dbReference type="CTD" id="84186"/>
    <dbReference type="GeneTree" id="ENSGT00950000183041"/>
    <dbReference type="OMA" id="HFGHACI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000020">
        <property type="entry name" value="Zinc finger CCHC domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="568" mass="64587" checksum="DB773FB9D8025981" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7V5</accession>
    <name>A0A670K7V5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Caveolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114587521</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <location evidence="10">Caveola</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the caveolin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028567734.1">
        <property type="nucleotide sequence ID" value="XM_028711901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K7V5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034875.1">
        <property type="protein sequence ID" value="ENSPMRP00000032876.1"/>
        <property type="gene ID" value="ENSPMRG00000021320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587521"/>
    <dbReference type="GeneTree" id="ENSGT00950000183006"/>
    <dbReference type="OMA" id="MCSSIKV"/>
    <dbReference type="OrthoDB" id="5917823at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070836">
        <property type="term" value="P:caveola assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018361">
        <property type="entry name" value="Caveolin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF16">
        <property type="entry name" value="CAVEOLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01210">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="165" mass="18654" checksum="5F4E67B799D7F451" modified="2020-06-17" version="1">MAQQGGGREEEEEEEEEVTLGKIDSRDPLTKEIDLVERDPKQINQEVVKVDFEDVIAEPEGTHSFDGVWKASNTTFTVSKYWCYRILSGALGLPLALLWGFLFACISFCHIWGAMPCIKSYFIEVQCCGRCYALCIRTFCDPLFEAVGKVCGDVRVALRKERAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDW3</accession>
    <name>A0A670KDW3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NUP188</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000036673.1">
        <property type="protein sequence ID" value="ENSPMRP00000034570.1"/>
        <property type="gene ID" value="ENSPMRG00000022141.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005742"/>
    <dbReference type="OMA" id="PMAEMNF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21094">
        <property type="entry name" value="Nup188_SH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="11">
        <location>
            <begin position="75"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="496"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1429"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1629"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1637"/>
            <end position="1647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1685" mass="189410" checksum="16896AE9A681C2DA" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEV9</accession>
    <name>A0A670KEV9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 178A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMEM178A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM178 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028580806.1">
        <property type="nucleotide sequence ID" value="XM_028724973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KEV9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037551.1">
        <property type="protein sequence ID" value="ENSPMRP00000035421.1"/>
        <property type="gene ID" value="ENSPMRG00000022917.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594819"/>
    <dbReference type="KEGG" id="pmua:114594819"/>
    <dbReference type="CTD" id="130733"/>
    <dbReference type="GeneTree" id="ENSGT00390000015299"/>
    <dbReference type="OMA" id="ATYAGLW"/>
    <dbReference type="OrthoDB" id="9941453at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045671">
        <property type="term" value="P:negative regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000024">
        <property type="entry name" value="Transmembrane protein 178A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039625">
        <property type="entry name" value="T178A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32005:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 178A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32005">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 178B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025330331" description="Transmembrane protein 178A" evidence="11">
        <location>
            <begin position="29"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="307" mass="33970" checksum="F5C446891E6FAB40" modified="2020-06-17" version="1">MRGGRGRGLVGALSLCLSLCSLALLVTAIFSDHWYETDPRRHRESCESRAGSAHSPEQRRRLLPLPHLPLRGAKRRLPRGGGGAAPAPAPTGHFPPLENWRALVGLGVLQSPCGRPLFATYAGLWRRCHFLGVDRDLDSLVERGITQRCTAIKYHFAPPIRLRNIPFNLTKTIQQDEWHLLHLRRITAGFLGMAAAVLLCGCIVTTVSFFWEESLTQHVAGLLFLMSGIFCTISLCTYAASVSYDLNRLPKFIYGLPDDVEHGYSWSIFCAWCSLGLIVAAGCLCTTYPLISRTKISHLKSTRDSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KG11</accession>
    <name>A0A670KG11_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alkaline ceramidase</fullName>
            <ecNumber evidence="15">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ACER1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:41299"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:41300"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an N-acylsphinganine + H2O = sphinganine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:33551"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33552"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_028569853.1">
        <property type="nucleotide sequence ID" value="XM_028714020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KG11"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036692.1">
        <property type="protein sequence ID" value="ENSPMRP00000034589.1"/>
        <property type="gene ID" value="ENSPMRG00000022435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588612"/>
    <dbReference type="KEGG" id="pmua:114588612"/>
    <dbReference type="CTD" id="125981"/>
    <dbReference type="GeneTree" id="ENSGT00730000110920"/>
    <dbReference type="OMA" id="NYKHSEH"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010446">
        <property type="term" value="P:response to alkaline pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46139">
        <property type="entry name" value="ALKALINE CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46139:SF2">
        <property type="entry name" value="ALKALINE CERAMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="263" mass="30738" checksum="5463808857070D23" modified="2020-06-17" version="1">MPSIFAYQSAEVDWCEENFAQSEYIAEYYNTISNVGFFILPPIMMFLNPQYIQYRPVPIPGLTIMSTLIGLFSGYFHMTLSYAGQMLDELSILWAIALCYAFWLPVHYYPPFIKNRDQFMWLVGIVTVLSTLMSFVKPTLNAYALNSVALHLLYLSNLEFRKCNNVRVHRLIRTMVVWWCIAITCWLTDKFLCGLCQRANFAYLHSIWHLCIVVTIFYCATTVVYFDVFYELPSSEPDVVYWPSEGSFFSLPYINLPKFKKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KH19</accession>
    <name>A0A670KH19_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KH19"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038853.1">
        <property type="protein sequence ID" value="ENSPMRP00000036683.1"/>
        <property type="gene ID" value="ENSPMRG00000023636.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163061"/>
    <dbReference type="OMA" id="YRIFNDH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02123">
        <property type="entry name" value="PA_C_RZF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044744">
        <property type="entry name" value="ZNRF4/RNF13/RNF167_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF20">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="1 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025622671" description="RING-type domain-containing protein" evidence="12">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="329" mass="36297" checksum="D8B606EA8139E75C" modified="2020-06-17" version="1">MQLSLLSPPSLVAFSLVLEVTLAKPFVYLVYTQNSTCLDFKAVPACFGPPLPQLGLTGYLVEVVPANACQPLVGPPVPKTSSLGYIALIRRYGCPFGLKVFHAQQAGYRAAVIYNFYSDLLVSMAVEAEGPKEKKILIPSLFIGGSASKVLRGLVRSGNGTKVTTVVPQEFGFVILLSLAVSGLVFAGCLKWHRRRQGIRVKTFRRGDSYNLCVICMADYEVGEKVKILPCSHAYHTTCINTWLLIQPRSGKTCPICKQKVAVRLWKEGESPELPPSPLWFLLLVNSYRIFNDHPNPLPSSINVQNSTLNDKCYSNPTNDFNCLQQSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KI41</accession>
    <name>A0A670KI41_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SRR1 domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SRRD</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KI41"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038112.1">
        <property type="protein sequence ID" value="ENSPMRP00000035965.1"/>
        <property type="gene ID" value="ENSPMRG00000023236.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003948"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="3">
        <location>
            <begin position="143"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="344" mass="38040" checksum="89A4C8F1761479F6" modified="2020-06-17" version="1">MAAAEWVRVTEVVCLPRAFPLWSLRVPRRDSPGGIALAPGFAWSAAERAKAGTPREGAGGGGASGGERSGAAERPRAPRTREKGRGGGCGRRGTILKSLPKHPAAGKGVTRPSVEKALSAFEKLQLTPPAESVLEPSSQLQEEPSRSRAQDLQCVCYGIGNFSSCVQARYQLAFLLLLLEELKIPEDLCYIFDPVFSTLEIKVLAHLGLTVLLENEEGKCCIHNPTIFYMVHCGKALYNNLLWSNWSIEALSKTVIIGNSFKGIEDRVLSRIFQKDYSYIAKVLIATDEEALPSHPQYLDIFNDTSVHCFPLEKLRDLPPEIWKLQEEPVYPDEDQPEIIRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIE8</accession>
    <name>A0A670KIE8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KIE8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038995.1">
        <property type="protein sequence ID" value="ENSPMRP00000036821.1"/>
        <property type="gene ID" value="ENSPMRG00000023718.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="AITHWIN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="178"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="939" mass="111999" checksum="CEED591B3A8EBFB9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJ18</accession>
    <name>A0A670KJ18_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KJ18"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039251.1">
        <property type="protein sequence ID" value="ENSPMRP00000037066.1"/>
        <property type="gene ID" value="ENSPMRG00000023865.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="115" mass="12445" checksum="54ADDC7E439FF68A" modified="2020-06-17" version="1">MTHPGAGLPIGLLTTIGAALGAGPHSVRPCLTFLRCNDVLPLFLSPWQKSELAAAIAVPCVFGGLLLIGLLVFMGLKIREKRQTEGTYRPAARSRLAFFVFKETVLRCAFQYATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJZ1</accession>
    <name>A0A670KJZ1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">PR domain zinc finger protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 16">PR domain-containing protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PRDM12</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14 16">Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15 16">Interacts with EHMT2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the class V-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KJZ1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038127.1">
        <property type="protein sequence ID" value="ENSPMRP00000035979.1"/>
        <property type="gene ID" value="ENSPMRG00000023242.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161616"/>
    <dbReference type="OMA" id="KHEDFHL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140713">
        <property type="term" value="F:histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990226">
        <property type="term" value="F:histone methyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050965">
        <property type="term" value="P:detection of temperature stimulus involved in sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19196">
        <property type="entry name" value="PR-SET_PRDM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000018">
        <property type="entry name" value="PR domain zinc finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PR domain zinc finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PR domain zinc finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001416">
        <property type="entry name" value="PR domain zinc finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044406">
        <property type="entry name" value="PRDM12_PR/SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017126">
        <property type="entry name" value="Znf_PRDM12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF20">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037163">
        <property type="entry name" value="PRDM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0010">Activator</keyword>
    <keyword evidence="8 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 16" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="20">
        <location>
            <begin position="88"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="356" mass="39663" checksum="A0AF3D06134E8667" modified="2020-06-17" version="1">MMGSVLPAEALVLKGGLKGPGLSLAEVITSDILHSFLYGRWRNVLGEQLFEEKAAGAHSNPKTAFTAEVLAQSFSGEVQKLSSLVLPSEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRIISPEHVDLCKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGNSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVLGLEEEQKKSKHEDFHAAEAGASSTGRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPNGSLQSHSPALPVPHPTSLAHHIPTMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KK39</accession>
    <name>A0A670KK39_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KK39"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038196.1">
        <property type="protein sequence ID" value="ENSPMRP00000036044.1"/>
        <property type="gene ID" value="ENSPMRG00000023284.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="OMA" id="CSTCECG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000005">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001808">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000116">
        <property type="entry name" value="Zinc finger protein 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002196">
        <property type="entry name" value="zinc finger protein 850-like isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="14">
        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="250"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="75"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="686"/>
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        <location>
            <begin position="1012"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1665" mass="189158" checksum="2EA61E1ACE325933" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKC4</accession>
    <name>A0A670KKC4_PODMU</name>
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        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">OR1B1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cell membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KKC4"/>
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        <property type="gene ID" value="ENSPMRG00000023697.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000141254"/>
    <dbReference type="OMA" id="ELAIFFE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="7tmA_OR1A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor 1A1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="41"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="321" mass="35979" checksum="9EBF3EFA4087B046" modified="2020-06-17" version="1">MDCENGTDVAEFVLLGFSSQPEEQPLYFLLFLLMYGAGLLGNVMMIILISLDARLQTPMYFLLRSLSMVDMGFISVTVPQMLAHIISTSKTIPFYSCMAQFFFFYVFGVTDLLMVSVMALDRYVAICNPLHYTTVMNQKVCGHLVAGCWIISTLHSMLHAGLLLRLSYRGDNHLAHFFCDHDPLLQLSCSDTSINETAIFFEGGLIILGPFVFIILTYVRIVVAVMRLSSSGRRKAFSTCGSHLTMVVLLYGAIIGVYFQPASSYSAQRGAVFAIMYTVITPMSNPYVYSLRNKDMKAAMKRLFSNCTDSCSSDRHLQRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLZ2</accession>
    <name>A0A670KLZ2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Relaxin-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a B chain and an A chain linked by two disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KLZ2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039284.1">
        <property type="protein sequence ID" value="ENSPMRP00000037099.1"/>
        <property type="gene ID" value="ENSPMRG00000023879.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154396"/>
    <dbReference type="OMA" id="WGCSKRE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04365">
        <property type="entry name" value="IlGF_relaxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051777">
        <property type="entry name" value="Insulin-like_neuro_ligands"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20968">
        <property type="entry name" value="ILGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20968:SF0">
        <property type="entry name" value="RELAXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0372">Hormone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025411167" description="Relaxin-3" evidence="12">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="13">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="14250" checksum="C6FBE09AABDF0CF9" modified="2020-06-17" version="1">MPKILLAMVLGVLLSELRLPSEARTPPYGVKLCGREFIRAVIFTCGGSRWRRAGECLETFAATSSSDEWVPIHAPPKDPSDYYGSWHGQQSHSPSEESWGFDRGARDVLAGLSNACCKWGCSKSEISSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HM34</accession>
    <name>A0A670HM34_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670HM34"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000753.1">
        <property type="protein sequence ID" value="ENSPMRP00000000708.1"/>
        <property type="gene ID" value="ENSPMRG00000000533.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="QVKEFKC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="652" mass="75703" checksum="B1BE82B52CA50BFD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMI0</accession>
    <name>A0A670HMI0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDZ domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PDZK1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NHER family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028582726.1">
        <property type="nucleotide sequence ID" value="XM_028726893.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028582727.1">
        <property type="nucleotide sequence ID" value="XM_028726894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HMI0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000896.1">
        <property type="protein sequence ID" value="ENSPMRP00000000843.1"/>
        <property type="gene ID" value="ENSPMRG00000000623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595971"/>
    <dbReference type="KEGG" id="pmua:114595971"/>
    <dbReference type="CTD" id="5174"/>
    <dbReference type="GeneTree" id="ENSGT00950000182849"/>
    <dbReference type="OMA" id="ISPCLYY"/>
    <dbReference type="OrthoDB" id="10009200at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141109">
        <property type="term" value="F:transporter activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06768">
        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF6">
        <property type="entry name" value="NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="134"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="242"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="364"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="510" mass="56347" checksum="ABC56FDFABA620C9" modified="2020-06-17" version="1">MMSPLRPRECKLTRKEAENYGFCLRLEKYKTGHLIRNVAKGSPAEKAGLKDGDRVLRVNGIFVDKEDHGTVADLVRESVDSVSFLVLDEKSYEDAHKEGVNFEELGQTLPVQQQAENTSVVTNGEPGPVTHPRLCYLVKEKNSYGFSLKTTEGHKGLFIIDLAPQGPAALAGVQPNDRLIEINGENVENDTHEEVVEKVRRSGNRLVFLVSNKETDQYYKSQNMQLRREMASLKLLPHKPRRLELAKGKNGYGFYLRMEQNGKGHLIKDIDSGSPAAEVGLKDNDILVAVNGESVEALDHEAVVEKIRKSGEKTVLLVVDDETDAMYKMAKISPCLYYHTPVQSPCEAEVPTCHTAKEHHKPRLCYLVKGPSGFGFRLNAIKGLPGQFIKEVKEGGPAERAGLQIDDILIEVNGANVENEDYDDVVARIHDGGNKLKLVVCGEEAYRHFKAQNMPVTAPMADPPDSSSDPPAYTEIQAPEPDGPLPEPRERANSSSSSLSVASEEDDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMT1</accession>
    <name>A0A670HMT1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HMT1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001018.1">
        <property type="protein sequence ID" value="ENSPMRP00000000958.1"/>
        <property type="gene ID" value="ENSPMRG00000000707.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154723"/>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig/MHC_CS"/>
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        <property type="entry name" value="MHC/Immunoglobulin"/>
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        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1 BETA CHAIN"/>
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    </dbReference>
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        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="123" mass="13851" checksum="DD55839B559683B6" modified="2020-06-17" version="1">GSPSLPKSLTSLPHLPCLPPTVQPKVKITPTDNVESSPHNTLLICTVNRFFPAGIEIKWFRNGKEEPKVWTTDLIRNGDWTFHIEVMLETNPERGDVYTCQVEHASFEGPVTVQWDLSLLSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP06</accession>
    <name>A0A670HP06_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HP06"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000808.1">
        <property type="protein sequence ID" value="ENSPMRP00000000762.1"/>
        <property type="gene ID" value="ENSPMRG00000000558.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger and SCAN domain containing 25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF423">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="12">
        <location>
            <begin position="167"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="541" mass="61061" checksum="5CC4FF9BE6F9550B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPK0</accession>
    <name>A0A670HPK0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 271-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114592158</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028575910.1">
        <property type="nucleotide sequence ID" value="XM_028720077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HPK0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001237.1">
        <property type="protein sequence ID" value="ENSPMRP00000001170.1"/>
        <property type="gene ID" value="ENSPMRG00000000866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592158"/>
    <dbReference type="KEGG" id="pmua:114592158"/>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="OMA" id="FRTHSEM"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000056">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Andersson L."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15085">
        <property type="entry name" value="NPFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025666917" evidence="1">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="14371" checksum="DE5CAB16F4EA286A" modified="2020-06-17" version="1">MEAARLLLALALLSGSLKPGRSLEEGIGSQEAEEPDGYPERLFSWMLQENEDHPVQIPSEEHPLGVLLRSLLHAVQRPGRSPSFLFQPQRFGREARASSSSGGLIKPRAWDAVAPQFLSMAVPQRFGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HS00</accession>
    <name>A0A670HS00_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox C6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXC6</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HS00"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002124.1">
        <property type="protein sequence ID" value="ENSPMRP00000002000.1"/>
        <property type="gene ID" value="ENSPMRG00000001468.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159254"/>
    <dbReference type="OMA" id="CHLTGGQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000879">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="236" mass="27011" checksum="39CD7D3E0D803143" modified="2020-06-17" version="1">MNSYFTNPSLSCHLTSGQEVLPNVAINSSAYDPVRHFSTYGAAVAQNRIYSSPFYSPQDNVVFSSSRGPYDYGSNAFYQEKDMLSSCRQNSMGHNTQTSIAQDFTSDQNRSTSQEQKTSIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLSSTLSGGGGAGAAADSLGAKEEKREETEEEKPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HSF9</accession>
    <name>A0A670HSF9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GALNT18</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Golgi apparatus membrane</location>
            <topology evidence="2 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A670HSF9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002807.1">
        <property type="protein sequence ID" value="ENSPMRP00000002638.1"/>
        <property type="gene ID" value="ENSPMRG00000001895.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155456"/>
    <dbReference type="OMA" id="WHRGNKS"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23475">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000017">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000012">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF37">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 18" id="KW-0430">Lectin</keyword>
    <keyword evidence="17 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="418"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="555" mass="64197" checksum="245B89AAC419CB57" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUU7</accession>
    <name>A0A670HUU7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AarF domain-containing protein kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ADCK1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT. The action of this enzyme is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HUU7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003768.1">
        <property type="protein sequence ID" value="ENSPMRP00000003514.1"/>
        <property type="gene ID" value="ENSPMRG00000002454.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158221"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010637">
        <property type="term" value="P:negative regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903852">
        <property type="term" value="P:positive regulation of cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="148"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="534" mass="60393" checksum="1CB73DED1405C749" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWM4</accession>
    <name>A0A670HWM4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HWM4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003895.1">
        <property type="protein sequence ID" value="ENSPMRP00000003635.1"/>
        <property type="gene ID" value="ENSPMRG00000002541.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000003905.1">
        <property type="protein sequence ID" value="ENSPMRP00000003645.1"/>
        <property type="gene ID" value="ENSPMRG00000002548.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063651"/>
    <dbReference type="OMA" id="KRLFWEF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052269">
        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973:SF3">
        <property type="entry name" value="PROTEIN TMED8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13897">
        <property type="entry name" value="GOLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="69"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="212" mass="24234" checksum="DCFFBFF001ECD95E" modified="2020-06-17" version="1">MTKYPDPQGPGDIVMIQSEYTGAVDVLTAELETTDLLGEQKKARPPPLIPPTTWTSAKIREFKTKMTKEKNARMVVKRGEVLTVRVPTHPDGKRVCWEFATEDYDIGFGVYFDWTSVTSTAITVQVSESSDEDDDDEEFEGPIPVGDVERGSRSYLRTRYGEIMPVYRRDSHREVQVGSHDYPGEGIYLLKFDNSYSLLRNKILFFHVYYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWN8</accession>
    <name>A0A670HWN8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RCC1 and BTB domain containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RCBTB2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028559665.1">
        <property type="nucleotide sequence ID" value="XM_028703832.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559673.1">
        <property type="nucleotide sequence ID" value="XM_028703840.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559679.1">
        <property type="nucleotide sequence ID" value="XM_028703846.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559686.1">
        <property type="nucleotide sequence ID" value="XM_028703853.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559695.1">
        <property type="nucleotide sequence ID" value="XM_028703862.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028559706.1">
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        <property type="nucleotide sequence ID" value="XM_028703883.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000003512.1"/>
        <property type="gene ID" value="ENSPMRG00000002466.1"/>
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        <property type="component" value="Chromosome 1"/>
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    </dbReference>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
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        <location>
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        <location>
            <begin position="200"/>
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        <location>
            <begin position="252"/>
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    </feature>
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        <location>
            <begin position="370"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="527" mass="57638" checksum="7DCD8DD461CAAE0B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWR6</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="93" mass="9972" checksum="838650834DF2336C" modified="2020-06-17" version="1">RCHLNIFPPSQQFQAEPQSTESVGIFVLNVLAGINFLSIRRSTACSNSSEYCSNKARVCSSPKCRGLDKVEPLPSLTGITVGSCGFANTSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HX47</accession>
    <name>A0A670HX47_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell cycle associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CAPRIN1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the caprin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028584044.1">
        <property type="nucleotide sequence ID" value="XM_028728211.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028584054.1">
        <property type="nucleotide sequence ID" value="XM_028728221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HX47"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003970.1">
        <property type="protein sequence ID" value="ENSPMRP00000003707.1"/>
        <property type="gene ID" value="ENSPMRG00000002292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596518"/>
    <dbReference type="KEGG" id="pmua:114596518"/>
    <dbReference type="CTD" id="4076"/>
    <dbReference type="GeneTree" id="ENSGT00940000153438"/>
    <dbReference type="OMA" id="GNNHWNS"/>
    <dbReference type="OrthoDB" id="10062814at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140677">
        <property type="term" value="F:molecular function activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061003">
        <property type="term" value="P:positive regulation of dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062029">
        <property type="term" value="P:positive regulation of stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106288">
        <property type="term" value="P:regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028816">
        <property type="entry name" value="Caprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022070">
        <property type="entry name" value="Caprin-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041637">
        <property type="entry name" value="Caprin-1_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22922:SF3">
        <property type="entry name" value="CAPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22922">
        <property type="entry name" value="GPI-ANCHORED PROTEIN P137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12287">
        <property type="entry name" value="Caprin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18293">
        <property type="entry name" value="Caprin-1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Caprin-1 dimerization" evidence="10">
        <location>
            <begin position="143"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic activation/proliferation-associated protein-1 C term" evidence="9">
        <location>
            <begin position="369"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="24"/>
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            <begin position="281"/>
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        </location>
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        </location>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="720" mass="79132" checksum="FC14FDFE46CC8D4C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXC1</accession>
    <name>A0A670HXC1_PODMU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="118" mass="12855" checksum="E7267605C4C4F53E" modified="2025-10-08" version="2">MPRKEQSDQVLTGPEVFNYFDSMAPLANNVLQHPSGAQEPSYVTPCLPSWQPLTLFQTPSLVECSLNFFSSLLGSRLGSCCCHPWPLSSPGPKERSSSEALFCALLPKEGGNDRLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0F4</accession>
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        <submittedName>
            <fullName evidence="21">Vesicle-trafficking protein SEC22b-B-like</fullName>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus</location>
            <location evidence="16">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028576354.1">
        <property type="nucleotide sequence ID" value="XM_028720521.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000005222.1">
        <property type="protein sequence ID" value="ENSPMRP00000004897.1"/>
        <property type="gene ID" value="ENSPMRG00000003365.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114592385"/>
    <dbReference type="GeneTree" id="ENSGT00940000156349"/>
    <dbReference type="OMA" id="SQGICYL"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vesicle-trafficking protein SEC22b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000004">
        <property type="entry name" value="vesicle-trafficking protein SEC22b"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="19">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="20">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="216" mass="24919" checksum="857C4D6DC10479A4" modified="2020-06-17" version="1">MVLLTMISRVQDGLLLAASMQETEQSNRNFQEYHSQAKQLFRKLGEHSPNRCSLQAGAMTFHYLISQGICYLTLCEAAYSKKLAFAFLEELQAEFWELYGKKVSSVSRPYAFIEFDLYIQKLKKSYLDTWSKRHLSSINMELQDVQKIMVTNIEEVLQRGEALSALDSKASNLSTLSKKYRHDAKLLNSRSAYAKAAATSLVFVILMIYIRFWWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0S7</accession>
    <name>A0A670I0S7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycoprotein hormone beta-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Thyrostimulin subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GPHB5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with GPHA2; this heterodimer interacts with thyroid-stimulating hormone receptor (TSHR), and hence stimulates cAMP production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycoprotein hormones subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028562765.1">
        <property type="nucleotide sequence ID" value="XM_028706932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I0S7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005361.1">
        <property type="protein sequence ID" value="ENSPMRP00000005032.1"/>
        <property type="gene ID" value="ENSPMRG00000003454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584806"/>
    <dbReference type="KEGG" id="pmua:114584806"/>
    <dbReference type="CTD" id="122876"/>
    <dbReference type="GeneTree" id="ENSGT00730000111179"/>
    <dbReference type="OMA" id="MAVRCDC"/>
    <dbReference type="OrthoDB" id="10006958at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031531">
        <property type="term" value="F:thyrotropin-releasing hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002155">
        <property type="term" value="P:regulation of thyroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00069">
        <property type="entry name" value="GHB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000029">
        <property type="entry name" value="glycoprotein hormone beta-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001545">
        <property type="entry name" value="Gonadotropin_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515:SF14">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00068">
        <property type="entry name" value="GHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025573766" description="Glycoprotein hormone beta-5" evidence="12">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoprotein hormone subunit beta" evidence="13">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="14541" checksum="5AFA7512ED25BB3A" modified="2020-06-17" version="1">MKLPSVVQGSLLLFILASWAGAPKPRSINLQTFTGCAVREFTFLAKKPGCKAMRITTDSCWGRCQTWEKPVLKPPYIEAHHRVCTYNETKLETVKLPNCAANVSPFYTYLKAIRCDCGMCLTETTECETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I2Y5</accession>
    <name>A0A670I2Y5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aristaless related homeobox</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ARX</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583289.1">
        <property type="nucleotide sequence ID" value="XM_028727456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I2Y5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006633.1">
        <property type="protein sequence ID" value="ENSPMRP00000006236.1"/>
        <property type="gene ID" value="ENSPMRG00000004216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596202"/>
    <dbReference type="KEGG" id="pmua:114596202"/>
    <dbReference type="CTD" id="170302"/>
    <dbReference type="GeneTree" id="ENSGT00940000160633"/>
    <dbReference type="OMA" id="SYREHAL"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021846">
        <property type="term" value="P:cell proliferation in forebrain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021853">
        <property type="term" value="P:cerebral cortex GABAergic interneuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021800">
        <property type="term" value="P:cerebral cortex tangential migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021831">
        <property type="term" value="P:embryonic olfactory bulb interneuron precursor migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072148">
        <property type="term" value="P:epithelial cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021759">
        <property type="term" value="P:globus pallidus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044241">
        <property type="term" value="P:lipid digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048663">
        <property type="term" value="P:neuron fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035265">
        <property type="term" value="P:organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046622">
        <property type="term" value="P:positive regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050678">
        <property type="term" value="P:regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000102">
        <property type="entry name" value="Aristaless related homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF337">
        <property type="entry name" value="ARISTALESS RELATED HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="269"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="11">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="271"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="508" mass="53347" checksum="FCA941F55123C2BF" modified="2020-06-17" version="1">MSNQYQEESCSDRPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAPSLAPLAGRIEQDKAGQGPAKGSPAGFEAAELHLPPKLRRLYGPGGGRLLARAERVEAGASSWDSLKISQAPQVSISRSKSYRENAPFPRAAAALDELSSGGGGGGGGGGLDGRPGRDDELLDDEDDEDDDDDEEEEAEELDEELEDDEELLAEAKEARRAAGGPVGVVGGPGAAPGTEGAGGCSPKEELLLPVDELVEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQSHPPGLPFPGPLSASHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAAAFPSLPPPPPGSAALPPGGTPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPAPSVESAVQSGGLSDPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGNSTGKEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4E8</accession>
    <name>A0A670I4E8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cannabinoid receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CNR1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">G-protein coupled receptor for cannabinoids. Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues. Signaling typically involves reduction in cyclic AMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18 19">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028578778.1">
        <property type="nucleotide sequence ID" value="XM_028722945.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028578779.1">
        <property type="nucleotide sequence ID" value="XM_028722946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I4E8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007245.1">
        <property type="protein sequence ID" value="ENSPMRP00000006798.1"/>
        <property type="gene ID" value="ENSPMRG00000004610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593942"/>
    <dbReference type="KEGG" id="pmua:114593942"/>
    <dbReference type="CTD" id="1268"/>
    <dbReference type="GeneTree" id="ENSGT01140000282530"/>
    <dbReference type="OMA" id="HKHANSA"/>
    <dbReference type="OrthoDB" id="5966748at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004949">
        <property type="term" value="F:cannabinoid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007413">
        <property type="term" value="P:axonal fasciculation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099509">
        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098921">
        <property type="term" value="P:retrograde trans-synaptic signaling by endocannabinoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000072">
        <property type="entry name" value="Cannabinoid receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000810">
        <property type="entry name" value="Canbinoid_rcpt_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002230">
        <property type="entry name" value="Cnbnoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037995">
        <property type="entry name" value="Cnoid_rcpt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00522">
        <property type="entry name" value="CANABINOID1R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00362">
        <property type="entry name" value="CANNABINOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 18" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 18 19" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12 18 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="14 18 19" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="21">
        <location>
            <begin position="134"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR037995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="473" mass="53257" checksum="1093DD5C93A446F3" modified="2020-06-17" version="1">MKSVLDGLADTTFRTITTDLLYMGSSDIQYEDFKSDMASKLGYYPQKFPLSSFRGDFRPKMTAGEDAILGGHPQDQINLTDFYNKTLTTFKDNEENIQCGDNFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLIVILQSRSLRCRPSYHFISSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLSYKRIVTRSKAVVAFCVMWTIAIVIAVLPLLGWNCKMLNSVCSDIFPLIDENYLLFWIGVTAVLLLFIVYAYMYILWKAHSHAVRMLQRGTQKSIIIHTSEDGKVHQITRPEQTRMDIRLAKTLVLILVVLIICWGPLLAIMLYDVFGKMNKLVKTIFAFCSMLCLLNSTVNPIIYALRSQDLRHAFRSMFPPCNGTAQPLDNSLESDCQHRHANNPGNVHKAAERCIKNTVKIAKVTMSVSSDTTAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4F7</accession>
    <name>A0A670I4F7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">mRNA-capping enzyme</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="17">mRNA 5'-triphosphate monophosphatase</fullName>
                <ecNumber evidence="17">3.6.1.74</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">mRNA 5'-phosphatase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">mRNA guanylyltransferase</fullName>
                <ecNumber evidence="17">2.7.7.50</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">GTP--RNA guanylyltransferase</fullName>
                <shortName evidence="17">GTase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="24" type="primary">RNGTT</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14 17">Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">In the C-terminal section; belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="17"/>
    <dbReference type="EC" id="2.7.7.50" evidence="17"/>
    <dbReference type="RefSeq" id="XP_028578780.1">
        <property type="nucleotide sequence ID" value="XM_028722947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I4F7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007260.1">
        <property type="protein sequence ID" value="ENSPMRP00000006808.1"/>
        <property type="gene ID" value="ENSPMRG00000004618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593943"/>
    <dbReference type="KEGG" id="pmua:114593943"/>
    <dbReference type="CTD" id="8732"/>
    <dbReference type="GeneTree" id="ENSGT00940000156953"/>
    <dbReference type="OMA" id="FWDIWMS"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050355">
        <property type="term" value="F:inorganic triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17664">
        <property type="entry name" value="Mce1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000111">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.430:FF:000001">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017074">
        <property type="entry name" value="mRNA_cap_enz_bifunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036958">
        <property type="entry name" value="mRNA_capping_HCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="2 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 17 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="22">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="23">
        <location>
            <begin position="104"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="18">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="19">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="347"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="462"/>
            <end position="464"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="532"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="599" mass="68524" checksum="8359BF43215899A5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4K0</accession>
    <name>A0A670I4K0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC52A3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>riboflavin(in) = riboflavin(out)</text>
            <dbReference type="Rhea" id="RHEA:35015"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the riboflavin transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587884.1">
        <property type="nucleotide sequence ID" value="XM_028732051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I4K0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007306.1">
        <property type="protein sequence ID" value="ENSPMRP00000006848.1"/>
        <property type="gene ID" value="ENSPMRG00000004650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598387"/>
    <dbReference type="KEGG" id="pmua:114598387"/>
    <dbReference type="CTD" id="113278"/>
    <dbReference type="GeneTree" id="ENSGT00390000003774"/>
    <dbReference type="OMA" id="CTWIGTN"/>
    <dbReference type="OrthoDB" id="9995836at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072388">
        <property type="term" value="P:flavin adenine dinucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006771">
        <property type="term" value="P:riboflavin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009357">
        <property type="entry name" value="Riboflavin_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 52, RIBOFLAVIN TRANSPORTER, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06237">
        <property type="entry name" value="SLC52_ribofla_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="465" mass="50656" checksum="31A7818ABF9ECECD" modified="2020-06-17" version="1">MALLTHVLACIFGIGSWMSINGVWVELPVLVNVLPEGWYLPSYLIIIIQLANVGPLFITLMHKWKPGLLSEVLVICVVVSTGVVACFLLAFLWHYTMDFGGARHSVAFFILTFCLSLVDCTSSVTFLPFMGRFHPRYITSYFIGEGLSGLVPALFALAQGAGISSCVEVAIPSNHTHRSNATLGNVSAGDPVPFRLETRYSPANFSSLVFFLILSGLMFSCLVAFFFLNRLPRVWDLSEQKLCASEITLHSIRKIPADGGLKEGFTNFPVEGKAESCSKEDEEGAPEKVVYSWTTLAFMYVLITWCSSLMYGILPSVQSYSCLPYSNLAYHLSTTLGAMAVPLACSISTFLPSRSLAFLSVLAATGTAFGAYNMGMATLSPCPPLNHSEWGDALIVISWVLFNGTLAYVKVMLGVILRGHSQSALVWYGAMEQLGGLIGAVIMFPLVNVYSVFKSADYCSFRCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I596</accession>
    <name>A0A670I596_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SRY-box transcription factor 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SOX21</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028584134.1">
        <property type="nucleotide sequence ID" value="XM_028728301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I596"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007364.1">
        <property type="protein sequence ID" value="ENSPMRP00000006889.1"/>
        <property type="gene ID" value="ENSPMRG00000004690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596569"/>
    <dbReference type="KEGG" id="pmua:114596569"/>
    <dbReference type="CTD" id="11166"/>
    <dbReference type="GeneTree" id="ENSGT00940000162795"/>
    <dbReference type="OMA" id="LHGHEAF"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043588">
        <property type="term" value="P:skin development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF313">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="285" mass="29595" checksum="F1FA8A1AF89E0371" modified="2020-06-17" version="1">MAKPVDHVKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVVPYGLPDAAEHHAHHLGHHHAALKAGALHGHEALLANPEKAAAAAAAAAARVFFPPTAAAAAAAAAAAAAGSPYSLLDLGSKMAAEISSSASGGSGGGGAASGLPYASSLAYPTAGGAFHAAAAAAAAAAASGGHTHSHPSPGNPGYMIPCNCSAWPSPGLQPPLAYILLPGMGKPQLDPYPAAYAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6C2</accession>
    <name>A0A670I6C2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small integral membrane protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SMIM13</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
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</entry>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028593704.1">
        <property type="nucleotide sequence ID" value="XM_028737871.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593706.1">
        <property type="nucleotide sequence ID" value="XM_028737873.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593707.1">
        <property type="nucleotide sequence ID" value="XM_028737874.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593708.1">
        <property type="nucleotide sequence ID" value="XM_028737875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IB81"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009539.1">
        <property type="protein sequence ID" value="ENSPMRP00000008928.1"/>
        <property type="gene ID" value="ENSPMRG00000006001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600980"/>
    <dbReference type="KEGG" id="pmua:114600980"/>
    <dbReference type="CTD" id="596"/>
    <dbReference type="GeneTree" id="ENSGT01130000278332"/>
    <dbReference type="OMA" id="IAVWMTE"/>
    <dbReference type="OrthoDB" id="6021377at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097138">
        <property type="term" value="C:BAD-BCL-2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:pore complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:BH3 domain binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031103">
        <property type="term" value="P:axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001783">
        <property type="term" value="P:B cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001782">
        <property type="term" value="P:B cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002326">
        <property type="term" value="P:B cell lineage commitment"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042100">
        <property type="term" value="P:B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001662">
        <property type="term" value="P:behavioral fear response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001658">
        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060402">
        <property type="term" value="P:calcium ion transport into cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043375">
        <property type="term" value="P:CD8-positive, alpha-beta T cell lineage commitment"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021747">
        <property type="term" value="P:cochlear nucleus development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097048">
        <property type="term" value="P:dendritic cell apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048546">
        <property type="term" value="P:digestive tract morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043583">
        <property type="term" value="P:ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904019">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032835">
        <property type="term" value="P:glomerulus development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060218">
        <property type="term" value="P:hematopoietic stem cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048873">
        <property type="term" value="P:homeostasis of number of cells within a tissue"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:regulation of nitrogen utilization"/>
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        <property type="term" value="P:regulation of protein localization"/>
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        <property type="term" value="P:response to nicotine"/>
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        <property type="term" value="P:smooth muscle cell migration"/>
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        <property type="term" value="P:T cell apoptotic process"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Apoptosis regulator Bcl-2"/>
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        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Apop_reg_Bcl2"/>
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        <property type="entry name" value="Bcl-2-like_sf"/>
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        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
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        <property type="entry name" value="Bcl-2_fam"/>
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    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
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        <property type="entry name" value="Bcl2/BclX"/>
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        <property type="entry name" value="Bcl2_BH1_motif_CS"/>
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        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
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        <property type="entry name" value="Bcl2_BH3_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003093">
        <property type="entry name" value="Bcl2_BH4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00865">
        <property type="entry name" value="bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="APOPTOSIS REGULATOR BCL-2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="APOPREGBCL2"/>
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        <property type="entry name" value="BCL2FAMILY"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50063">
        <property type="entry name" value="BH4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis regulator Bcl-2 family BH4" evidence="19">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="BH4" evidence="16">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
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            <dbReference type="ARBA" id="ARBA00018573"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="232" mass="25980" checksum="70C0FF513757EA76" modified="2020-06-17" version="1">MMAQTGIRGYDTREIVQTYIHYKLSQKGYDWVASEDREDLPSPPLPPDPPAAETFPNLARLASHPSELPVSNVAPAGGPHPVPQVVHATLRQAGDEFSRRYRRDFAQMSGQLHLTPVTARARFAAVVEELFRDGVNWGRIVAFFEFGGMMCVESVSREMSPLVDNITVWMTDYLNGHLDNWIQDNGGWDAFVELYSNNMRPLFDFSWLPLKTILSLAVVGACITLGAYLGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBZ0</accession>
    <name>A0A670IBZ0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IBZ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009826.1">
        <property type="protein sequence ID" value="ENSPMRP00000009203.1"/>
        <property type="gene ID" value="ENSPMRG00000006177.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156860"/>
    <dbReference type="OMA" id="CSYPLID"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025675343" description="Lipase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="93"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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</entry>
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    <dbReference type="AlphaFoldDB" id="A0A670IGY6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011892.1">
        <property type="protein sequence ID" value="ENSPMRP00000011133.1"/>
        <property type="gene ID" value="ENSPMRG00000007430.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154846"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF54">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ACB" evidence="8">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="87" mass="9925" checksum="F980CD519DE58130" modified="2020-06-17" version="1">MWSLHASATMAQAEFEKAAEEVKKLKTQPTDQEMLDIYSHSKQATVGDVNTDHRGMLDFKGKVKWDAWNSLKGMSKEDAMKEKYGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILX7</accession>
    <name>A0A670ILX7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 4 L six family member 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the L6 tetraspanin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ILX7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013429.1">
        <property type="protein sequence ID" value="ENSPMRP00000012574.1"/>
        <property type="gene ID" value="ENSPMRG00000008426.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234590"/>
    <dbReference type="OMA" id="SYLFNQT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008661">
        <property type="entry name" value="L6_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14198:SF20">
        <property type="entry name" value="TRANSMEMBRANE 4 L SIX FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14198">
        <property type="entry name" value="TRANSMEMBRANE 4 L6 FAMILY MEMBER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05805">
        <property type="entry name" value="L6_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23295" checksum="9ED63B79F1DD6C48" modified="2020-06-17" version="1">MKRYRMCAGKCSKCIGIALLPLAVCAIVSNLLLYFPNGEVLEPRRITDLVWFFHGILGAGILVFLPAFMILGAGEAKCCANRCGMVLSLVFAVLGALGGLYCVIISSLGLISGPLCDIGDEVYIYPFRNDSLVDNYLFNQTTWSICKKPENIILWNIVLFSLLLAIGLAEAILCLIQVVNSLIGFIRGLRERKVSARETIGMRTSDLPTSNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IMG5</accession>
    <name>A0A670IMG5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="13">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SNRPD2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028597967.1">
        <property type="nucleotide sequence ID" value="XM_028742134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IMG5"/>
    <dbReference type="SMR" id="A0A670IMG5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013753.1">
        <property type="protein sequence ID" value="ENSPMRP00000012881.1"/>
        <property type="gene ID" value="ENSPMRG00000008617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603263"/>
    <dbReference type="KEGG" id="pmua:114603263"/>
    <dbReference type="CTD" id="6633"/>
    <dbReference type="GeneTree" id="ENSGT00390000017608"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000069">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="15">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="118" mass="13527" checksum="D986059D82B7E045" modified="2020-06-17" version="1">MSLLNKPKSEMTPEELQKREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEVPKSGKGKKKSKPVNKDRYISKMFLRGDSVIVVLRNPLIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IS81</accession>
    <name>A0A670IS81_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gag-Pol polyprotein</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IS81"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015602.1">
        <property type="protein sequence ID" value="ENSPMRP00000014606.1"/>
        <property type="gene ID" value="ENSPMRG00000009747.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160750"/>
    <dbReference type="OMA" id="FANEAIM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09273">
        <property type="entry name" value="RNase_HI_RT_Bel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040643">
        <property type="entry name" value="MLVIN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18697">
        <property type="entry name" value="MLVIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="11">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="149"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="13">
        <location>
            <begin position="582"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="14">
        <location>
            <begin position="847"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1222"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1256" mass="139022" checksum="5CAED4766A3FF4C8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IU94</accession>
    <name>A0A670IU94_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Snail family transcriptional repressor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SNAI1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591016.1">
        <property type="nucleotide sequence ID" value="XM_028735183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IU94"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016836.1">
        <property type="protein sequence ID" value="ENSPMRP00000015768.1"/>
        <property type="gene ID" value="ENSPMRG00000010532.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599628"/>
    <dbReference type="KEGG" id="pmua:114599628"/>
    <dbReference type="CTD" id="6615"/>
    <dbReference type="GeneTree" id="ENSGT00940000154681"/>
    <dbReference type="OMA" id="QSYPMLA"/>
    <dbReference type="OrthoDB" id="5428132at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060536">
        <property type="term" value="P:cartilage morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010631">
        <property type="term" value="P:epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:epithelial to mesenchymal transition involved in endocardial cushion formation"/>
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        <property type="term" value="P:left/right pattern formation"/>
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        <property type="term" value="P:mesoderm formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of DNA damage response, signal transduction by p53 class mediator"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0010957">
        <property type="term" value="P:negative regulation of vitamin D biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="term" value="P:positive regulation of epithelial to mesenchymal transition"/>
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        <property type="term" value="P:regulation of bicellular tight junction assembly"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:roof of mouth development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:001869">
        <property type="entry name" value="Snail family zinc finger 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Snail zinc finger protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Snail zinc finger protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF37">
        <property type="entry name" value="ZINC FINGER PROTEIN SNAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
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    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
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    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="258" mass="28880" checksum="DE8962FD787B1A98" modified="2020-06-17" version="1">MPRSFLVKKHFSASKKPNYSELESQTVIVSPCFYEKYPISVIPQPDLLSAGSYYPPLVWDTGLLSNFFTSEPEYKKSATSPPSPGSKPLDLTSSEEEDGKTTSDPPSPASSATEAEKFHCSQCNKSYSTFAGLSKHRQLHCDSQARKSFSCKNCEKEYVSLGALKMHIRSHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCTHCNRAFADRSNLRAHLQTHSDVKKYQCKTCSRTFSRMSLLHKHEETGCTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUV7</accession>
    <name>A0A670IUV7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM/homeobox protein Lhx9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LHX9</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IUV7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016776.1">
        <property type="protein sequence ID" value="ENSPMRP00000015710.1"/>
        <property type="gene ID" value="ENSPMRG00000010496.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158821"/>
    <dbReference type="OMA" id="LICCECK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008585">
        <property type="term" value="P:female gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035262">
        <property type="term" value="P:gonad morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09469">
        <property type="entry name" value="LIM1_Lhx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09377">
        <property type="entry name" value="LIM2_Lhx2_Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000039">
        <property type="entry name" value="LIM/homeobox protein Lhx9 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000033">
        <property type="entry name" value="LIM/homeobox protein Lhx9 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF95">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN LHX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="50"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="251"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="253"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="316" mass="35555" checksum="7143BB8F8A690D13" modified="2020-06-17" version="1">MLFHGISGGHIQGIMEEMERRSKTESRLAKGAQMNGREANMPPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCTTCNKTLTTGDHFGMKDNVVYCRAHFESLLQGTDPASYPPPQLSYTELAAKGGGLALPYFNGTGTVQKGRPRKRKSPALGVDLVSYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQGEQILGHYSQTSRRLKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IV08</accession>
    <name>A0A670IV08_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ciliary microtubule inner protein 2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CIMIP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IV08"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016651.1">
        <property type="protein sequence ID" value="ENSPMRP00000015591.1"/>
        <property type="gene ID" value="ENSPMRG00000010392.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166013"/>
    <dbReference type="OMA" id="CCGQDLT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146:SF8">
        <property type="entry name" value="PROTEIN FAM166B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="9">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="9">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="279" mass="30790" checksum="09D7ECCFC0FDBD84" modified="2020-06-17" version="1">HGAQESKVSHCLHFFPFYFYGGYCPRYKFMLGQTYGKLTSQLLTSPEADHSGRLLLQPNCSPRDTEAPPEQNESGGKLPLLGRRTIPGYTGFIPRSQNHFAKTYSEICKEASSEFARQLLRGAGQREAWMAAGGESPKDTKPESHVRGTPEGRLWSGVGFCGGSNSFDSCNAGFTGFIPRAQYLIGASYPVITHRALAEFDRMRWRQRQGPSGSSCDAQKGGNALPPLTKTYPTDMGLLPHYRGYVPGYKFQFGHTYGQLTFDALGQSTLEKQVLDGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVS2</accession>
    <name>A0A670IVS2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deleted in lung and esophageal cancer protein 1 Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IVS2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017131.1">
        <property type="protein sequence ID" value="ENSPMRP00000016050.1"/>
        <property type="gene ID" value="ENSPMRG00000010721.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006098"/>
    <dbReference type="OMA" id="APGMCCK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033304">
        <property type="entry name" value="DLEC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059041">
        <property type="entry name" value="Ig_DLEC1_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348:SF1">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23277">
        <property type="entry name" value="Ig_Dlec1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deleted in lung and esophageal cancer protein 1 Ig-like" evidence="1">
        <location>
            <begin position="243"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="499" mass="56427" checksum="071990980EC9C97E" modified="2020-06-17" version="1">MYTSEFISANTVENMIKSRGGDNSHHEQFVKELQKVHKEYNGRLTEADMLERHIIQARARAAAEEERIVNLCQMEVPENYSHIKMPPVRSTFRWCVDSKLLKDHNLICPEDYIMDPEIISRAPKGKLSNLNECERIHRKPVSESGFFLFPHACCQKKDRPSQKSAWKNDMSRPQRQKDRAYLQRLEDRHNFLKNPRFFPPNSLCGGKSLILPQKKVQRMIAGRKRTTARNASQDVYMLPYFLTFLSLQMTVELQNMTSTSQCLRIIPPATDAFSIGLGHFPGEGGLVAPGMSCYYVVQFIPEYLSDYKDYILVESQTTYPLLVPLEGRRPPPILTLPHILDCGPCLVGGVKFTEFLCKNEGSSIGKFCIMPKHIWPPPHFRAVATLGYVEQEPFGIRPAVFELAPGQSTLIEVVFMPTVPEVVSVKYILICDNCQINDLTVTGLGQLIALKLLSVTGGESSPMPGELVDVTAKHLVRFGSLNPKSKAEKTLVLRNLTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWS2</accession>
    <name>A0A670IWS2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Methylcytosine dioxygenase TET</fullName>
            <ecNumber evidence="18">1.14.11.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TET3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 18">
            <text>a 5-formyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53832"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="Rhea" id="RHEA-COMP:13657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="ChEBI" id="CHEBI:137732"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:53828"/>
            <dbReference type="Rhea" id="RHEA-COMP:13315"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:136731"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 5-methyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:52636"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="Rhea" id="RHEA-COMP:13315"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="ChEBI" id="CHEBI:136731"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="18">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18">The zinc ions have a structural role.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the TET family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.80" evidence="18"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017729.1">
        <property type="protein sequence ID" value="ENSPMRP00000016628.1"/>
        <property type="gene ID" value="ENSPMRG00000011065.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157631"/>
    <dbReference type="OMA" id="SVYSCHS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001939">
        <property type="term" value="C:female pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001940">
        <property type="term" value="C:male pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070579">
        <property type="term" value="F:DNA 5-methylcytosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141166">
        <property type="term" value="P:chromosomal 5-methylcytosine DNA demethylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044727">
        <property type="term" value="P:epigenetic programing of male pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044029">
        <property type="term" value="P:positive regulation of gene expression via chromosomal CpG island demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18897">
        <property type="entry name" value="TET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040175">
        <property type="entry name" value="TET1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046942">
        <property type="entry name" value="TET_oxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23358">
        <property type="entry name" value="METHYLCYTOSINE DIOXYGENASE TET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23358:SF4">
        <property type="entry name" value="METHYLCYTOSINE DIOXYGENASE TET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01333">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 18" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 18" id="KW-0408">Iron</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="20">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="563"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="865"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1532"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1615"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1822"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1959"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1615"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1643"/>
            <end position="1654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="2016" mass="222143" checksum="3C25F9160BD71B61" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXG4</accession>
    <name>A0A670IXG4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 263</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM263 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028603222.1">
        <property type="nucleotide sequence ID" value="XM_028747389.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028603223.1">
        <property type="nucleotide sequence ID" value="XM_028747390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IXG4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016947.1">
        <property type="protein sequence ID" value="ENSPMRP00000015872.1"/>
        <property type="gene ID" value="ENSPMRG00000010596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605806"/>
    <dbReference type="KEGG" id="pmua:114605806"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="UPF0444"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15475">
        <property type="entry name" value="UPF0444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="116" mass="11838" checksum="D917230532C53F7A" modified="2020-06-17" version="1">MNQTDRNEQDVPAYLNEEPPEDSLKDHPQQQPGMLSRVTGGLFSITKGAVGATIGGVAWIGGKSLEMTKTAVTAVPSMGVGLVKGSVSAVTGGVTAVGSAITSKVPLTGKKKDKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXX6</accession>
    <name>A0A670IXX6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DLG associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DLGAP2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IXX6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017382.1">
        <property type="protein sequence ID" value="ENSPMRP00000016284.1"/>
        <property type="gene ID" value="ENSPMRG00000010879.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157913"/>
    <dbReference type="OMA" id="PYSWSPT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099572">
        <property type="term" value="C:postsynaptic specialization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF3">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="854" mass="95621" checksum="04B2381A7B68C00C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZC7</accession>
    <name>A0A670IZC7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">DGAT1</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O</text>
            <dbReference type="Rhea" id="RHEA:38379"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:38380"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38219"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38220"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38163"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:38164"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38435"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:37915"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:37916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-O-(9Z-octadecenyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:55340"/>
            <dbReference type="ChEBI" id="CHEBI:34116"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:197429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:55341"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:55344"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:138735"/>
            <dbReference type="ChEBI" id="CHEBI:197429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:55345"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38307"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:75729"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38308"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:55296"/>
            <dbReference type="ChEBI" id="CHEBI:45479"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:138722"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38439"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:38440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:37911"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:37912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38071"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:38072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:11488"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:63410"/>
            <dbReference type="EC" id="2.3.1.76"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:11489"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38175"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:38176"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:10869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hexadecan-1-ol + hexadecanoyl-CoA = hexadecyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38167"/>
            <dbReference type="ChEBI" id="CHEBI:16125"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75584"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:38168"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA</text>
            <dbReference type="Rhea" id="RHEA:38211"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75586"/>
            <dbReference type="ChEBI" id="CHEBI:75608"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:38212"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38171"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75586"/>
            <dbReference type="ChEBI" id="CHEBI:75587"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:38172"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homodimer or homotetramer; both forms have similar enzymatic activities.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 29">Endoplasmic reticulum membrane</location>
            <topology evidence="8 29">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 29">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591795.1">
        <property type="nucleotide sequence ID" value="XM_028735962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IZC7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018661.1">
        <property type="protein sequence ID" value="ENSPMRP00000017528.1"/>
        <property type="gene ID" value="ENSPMRG00000011583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600142"/>
    <dbReference type="KEGG" id="pmua:114600142"/>
    <dbReference type="CTD" id="8694"/>
    <dbReference type="GeneTree" id="ENSGT00950000183081"/>
    <dbReference type="OMA" id="RCHDYRR"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003846">
        <property type="term" value="F:2-acylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050252">
        <property type="term" value="F:retinol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046339">
        <property type="term" value="P:diacylglycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055089">
        <property type="term" value="P:fatty acid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:lipid storage"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:monoacylglycerol biosynthetic process"/>
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    </dbReference>
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        <property type="entry name" value="Diacylglycerol_acylTrfase1"/>
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        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
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        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
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        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Oat_dag"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 29" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13 29" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 29 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 29" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 32" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="192"/>
            <end position="213"/>
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    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="292"/>
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    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="342"/>
            <end position="362"/>
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    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="411"/>
            <end position="433"/>
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        <location>
            <begin position="439"/>
            <end position="458"/>
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    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="30">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000633"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001313"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001349"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047807"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="Ensembl" id="ENSPMRP00000017528.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="495" mass="56202" checksum="9EE753D73B274CAF" modified="2020-06-17" version="1">MEAACEGAGRGDAPEEKEKQHRRRRPEEPSGGMGERGAAGRRAAAGAPPGGGDSRRGAGDAAHPPEGGDFRCHRLQDSLLSSASGYSNYRGILNWCVVMLVLSNARLFLENLIKYGILVDPIQVISLFLKDPYSWPALCLIIVANVFALAALHIEKRLAVGSMSEHLGAVLHTVNLLTILCFPALVTLAVTSITPVGAVFALGVHTILFLKLFSFKDVNKWCREKRQAKAARTRSAAGSQKANGNVASGAVAYPANLTYRDLYYFLFAPTLCYELNFPRSPRVRKRFLLRRLAEMLFFLQLMVGLIQQWMVPTIQNSMKPFRDMDYSRIIERLLKLAVPNHLIWLIFFYWFFHSSLNVIAEIMQFGDREFYRDWWNSETVTYFWQNWNIPVHKWCLRHFYKPMMKKGAGKWVAQTGVFFASAFFHEYLVSVPLKMFRPWAFIGMMAQIPLAWFVGRFLQGNYGNAAVWISLIIGQPIAVLMYVHDYYVLNYEGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1E8</accession>
    <name>A0A670J1E8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Embryonic pepsinogen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114598349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J1E8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019491.1">
        <property type="protein sequence ID" value="ENSPMRP00000018328.1"/>
        <property type="gene ID" value="ENSPMRG00000012058.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162710"/>
    <dbReference type="OMA" id="HHYDIST"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000006">
        <property type="entry name" value="Cathepsin E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pepsin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF13">
        <property type="entry name" value="CHYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025331511" evidence="6">
        <location>
            <begin position="17"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="76"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="107"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="383" mass="41811" checksum="49DBF8D2723E6971" modified="2020-06-17" version="1">MKYLAVLFTIVALSECLVKIPLQRGTKVRDTLKKKNLLEDLLQKHRYDIGTKYNSAFSKAALVAEEPLLNSLDTEYYGTIYIGTPPQKFTVVFDTGSSNLWVPSVYCSSPACQKHQRFNPSQSSTFQSTRQTISIQYGTGSMQGYLGYDTVKVSGLAVSDQPFGLSSSEPGIIFVYSQFDGILGLGYPNIAVDGATPVFDNMVEQGLVQQNLFSVYLSRKTSGSMVIFGGVDHSYFTGPINWIPVTQQGYWQIAVDSILVNGQTVACSGGCQAIVDTGTSLVAGPAYEISKIQNAIGATAAQYGEYKINCGNLPNMPNVVFVINGIQYPLTPSAYTNQIMQAECTSGFQNTAGDLWILGDVFIREYYSIFDRENNRVGLAKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2E3</accession>
    <name>A0A670J2E3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">YWHAQ</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            </authorList>
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        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="9" key="2">
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Spectrin_repeat"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="43"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="156"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
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            <end position="793"/>
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            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="926" mass="106651" checksum="8871E843FC7E31B3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2U2</accession>
    <name>A0A670J2U2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
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    <dbReference type="Ensembl" id="ENSPMRT00000019726.1">
        <property type="protein sequence ID" value="ENSPMRP00000018561.1"/>
        <property type="gene ID" value="ENSPMRG00000011976.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183019"/>
    <dbReference type="OMA" id="XVQIYEL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000003">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000004">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit gamma 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF122">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="269"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="351"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="424"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="498"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="49"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="555" mass="61169" checksum="0B08AB7127CB7866" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4E5</accession>
    <name>A0A670J4E5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tectonic-1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the tectonic-like complex (also named B9 complex).</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J4E5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020321.1">
        <property type="protein sequence ID" value="ENSPMRP00000019141.1"/>
        <property type="gene ID" value="ENSPMRG00000012506.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00570000079101"/>
    <dbReference type="OMA" id="TINMMAR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040354">
        <property type="entry name" value="TCTN1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011677">
        <property type="entry name" value="TCTN1-3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611">
        <property type="entry name" value="TECTONIC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611:SF1">
        <property type="entry name" value="TECTONIC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07773">
        <property type="entry name" value="TCTN_DUF1619"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tectonic-1-3" evidence="2">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="2">
        <location>
            <begin position="141"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="346" mass="37389" checksum="BDBA0B65B7BAF61A" modified="2020-06-17" version="1">MQMCFSECTPLDKALRSLVNVPSSLCLVCAPDCSQLDLLRLIRCILQVNITIQSITVQSPEGLRTRLKNTDALILPTLNGQSCSNVVLEASYLITFTEAGEIASAGVSLILGTINMMARFVLQSFEIRFIQEETQPVRLSGSPGYVVGLPIKAGFRTAGSGIVQSTNEAGQLTLMKSTPAQNCLAVEGVRTPVLFGYSMLSGCQLRITKDADCRLLAPALLSVLKGQNFPDYVASFGDSLPQNELDWLQISNNVTEASTCEIPVSFQIEVKWTKYGSLVNPQAKIVSLTATVMTAALPQVDSGSEQTIQIFSSATFVDVSAPAEPGYKARPPIEANLPFDFFFPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4R1</accession>
    <name>A0A670J4R1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein Rab-43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RAB43</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028574782.1">
        <property type="nucleotide sequence ID" value="XM_028718949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J4R1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020717.1">
        <property type="protein sequence ID" value="ENSPMRP00000019513.1"/>
        <property type="gene ID" value="ENSPMRG00000012725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591649"/>
    <dbReference type="KEGG" id="pmua:114591649"/>
    <dbReference type="CTD" id="339122"/>
    <dbReference type="GeneTree" id="ENSGT00940000161980"/>
    <dbReference type="OMA" id="FIERHGN"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090382">
        <property type="term" value="P:phagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035526">
        <property type="term" value="P:retrograde transport, plasma membrane to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01864">
        <property type="entry name" value="Rab19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000803">
        <property type="entry name" value="Ras-related protein Rab-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048040">
        <property type="entry name" value="Rab19/43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="215" mass="23841" checksum="F14DDD9135E8BD20" modified="2020-06-17" version="1">MPGPPVAGAPPGPDPEERYDFLFKLVLIGDASVGKTCLVQRFKTGAFAERQGSTIGVDFTMKSLEIQGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDISKRGSFQSIPRWIEDVRKYAGSNIVQLLIGNKSDLSDRREVQLEEAQSLAEHYDITCAIETSAKDSSNVEEAFVKMATELMMRHGGPMFSEQNTDSIKLDSKDVEGWGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J619</accession>
    <name>A0A670J619_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UbiA prenyltransferase domain-containing protein 1</fullName>
            <ecNumber evidence="14">2.5.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">UBIAD1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:84503"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>menadiol + (2E,6E,10E)-geranylgeranyl diphosphate = menaquinol-4 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:74083"/>
            <dbReference type="ChEBI" id="CHEBI:6746"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:193091"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:74084"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028596482.1">
        <property type="nucleotide sequence ID" value="XM_028740649.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028596483.1">
        <property type="nucleotide sequence ID" value="XM_028740650.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028596484.1">
        <property type="nucleotide sequence ID" value="XM_028740651.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028596485.1">
        <property type="nucleotide sequence ID" value="XM_028740652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J619"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021199.1">
        <property type="protein sequence ID" value="ENSPMRP00000019963.1"/>
        <property type="gene ID" value="ENSPMRG00000013017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602438"/>
    <dbReference type="KEGG" id="pmua:114602438"/>
    <dbReference type="CTD" id="29914"/>
    <dbReference type="GeneTree" id="ENSGT00390000012439"/>
    <dbReference type="OMA" id="QWIEGAR"/>
    <dbReference type="OrthoDB" id="203513at2759"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042371">
        <property type="term" value="P:vitamin K biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000005">
        <property type="entry name" value="UbiA prenyltransferase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
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    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
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    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="132"/>
            <end position="153"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="186"/>
            <end position="207"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="241"/>
            <end position="259"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="265"/>
            <end position="292"/>
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        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="336" mass="36533" checksum="703E3CB8A5B4A509" modified="2020-06-17" version="1">MEAEDEMEKINIVSENNQESEPEDQGAALLGSPKSLPSTWQHKCASYVLALRPWSFSASLTPVALGSALAYRSLGTLDPGLLVGSAVTVLAVHGAGNLVNTYYDFSKGIDHKKSDDRTLVDRILEPQDVVRFGVFLYTLGCISAACLYCLSTLKLEHLALIYFGGLSSSFLYTGGIGFKYVALGDVVILITFGPLAVMFAYAVQVGYLSVSPLLYAVPLALSTEAILHSNNTRDMESDRQAGIVTLAILIGPTCSYFLYNALLFLPYLVFCVLATRYTITMALPLLTIPMAFSLERQFRSQSFVKLPQRTAKLNLLLGLFYVFAILSAPPGALPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J866</accession>
    <name>A0A670J866_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">Calglandulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CETN3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">May be involved in the cellular control mechanism of the secretion of toxins from the gland into the venom.</text>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="167" mass="19588" checksum="F020417D8994AFC0" modified="2020-06-17" version="1">MNLVARTELPVDKTKRKKRRDLTEEQKQEIKDAFELFDTDKDRAIDYHELKVAMRALGFDVKKADVLKILKDYDREGTGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMTDEELRAMIEEFDKDGDGEINQEEFIAIMTGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J890</accession>
    <name>A0A670J890_PODMU</name>
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        <submittedName>
            <fullName evidence="2">FANCD2 opposite strand protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC114606806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028605219.1">
        <property type="nucleotide sequence ID" value="XM_028749386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J890"/>
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        <property type="gene ID" value="ENSPMRG00000013306.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606806"/>
    <dbReference type="KEGG" id="pmua:114606806"/>
    <dbReference type="GeneTree" id="ENSGT00390000000631"/>
    <dbReference type="OMA" id="MAMAICR"/>
    <dbReference type="OrthoDB" id="9433753at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027966">
        <property type="entry name" value="FANCD2OS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31036">
        <property type="entry name" value="FANCD2 OPPOSITE STRAND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31036:SF0">
        <property type="entry name" value="FANCD2 OPPOSITE STRAND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15124">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="173" mass="18939" checksum="35918A717C3944F0" modified="2020-06-17" version="1">MAGGYQLWAPWSPLDESLQWLRGARSVGTKHPFRSGQSPAAADLEVQLCFQGLSLVLEPGAKTGAGQPRPPGAAGETRGRSSSVHRPQVVRLSGLDSVFGHLVTAQPPRWTGSLRVSEPSAFSQVISPRQRWPRGLQEPQVRVAMAMCRQMLRAILLLYAVYKKCAFALQHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J9C7</accession>
    <name>A0A670J9C7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease domain-containing 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114605294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028602185.1">
        <property type="nucleotide sequence ID" value="XM_028746352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J9C7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021505.1">
        <property type="protein sequence ID" value="ENSPMRP00000020254.1"/>
        <property type="gene ID" value="ENSPMRG00000013187.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605294"/>
    <dbReference type="KEGG" id="pmua:114605294"/>
    <dbReference type="GeneTree" id="ENSGT01030000234592"/>
    <dbReference type="OMA" id="NGHHDDY"/>
    <dbReference type="OrthoDB" id="69221at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039015">
        <property type="entry name" value="ENDOD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472:SF26">
        <property type="entry name" value="ENDONUCLEASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472">
        <property type="entry name" value="ENDONUCLEASE DOMAIN-CONTAINING 1 PROTEIN ENDOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025400839" evidence="1">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="276" mass="30861" checksum="1573AB08223C0F4E" modified="2020-06-17" version="1">MLPILLLVAVCQLNSPGRAEVVTSFEDVCPQFFFRGTPPSIGLAPPHPARICQRYKNQYRFATLYDRDNRIPVFSAYIYNPGQAKRPNTWRIEPQLLDLALPPEMETEGSLLQEGGDMQEALQGSQAVLLDYKNLTDFNRGHLNPNGHQPDRDAKSSTFTLTNIVPQYIKLNGGAWNHYEQSTMASKTEGCQETFAVVGAVPGDSFIAKGRVNKPSQVWSAACCVIDNNHLRSWAIIARNDENAVQTLTLGQLEEKLAELYNQSHISLFHSDCPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J9F7</accession>
    <name>A0A670J9F7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Protein-arginine deiminase</fullName>
            <ecNumber evidence="3 8">3.5.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114602428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the deimination of arginine residues of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18089"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10588"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:83397"/>
            <dbReference type="EC" id="3.5.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the protein arginine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.15" evidence="3 8"/>
    <dbReference type="RefSeq" id="XP_028596463.1">
        <property type="nucleotide sequence ID" value="XM_028740630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J9F7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021080.1">
        <property type="protein sequence ID" value="ENSPMRP00000019847.1"/>
        <property type="gene ID" value="ENSPMRG00000012934.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602428"/>
    <dbReference type="KEGG" id="pmua:114602428"/>
    <dbReference type="GeneTree" id="ENSGT00940000153217"/>
    <dbReference type="OMA" id="VCPLLEN"/>
    <dbReference type="OrthoDB" id="5102063at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04214">
        <property type="entry name" value="PAD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1700:FF:000001">
        <property type="entry name" value="Protein-arginine deiminase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000003">
        <property type="entry name" value="Protein-arginine deiminase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1700">
        <property type="entry name" value="Protein-arginine deiminase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1860">
        <property type="entry name" value="Protein-arginine deiminase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004303">
        <property type="entry name" value="PAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013530">
        <property type="entry name" value="PAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036556">
        <property type="entry name" value="PAD_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013732">
        <property type="entry name" value="PAD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038685">
        <property type="entry name" value="PAD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013733">
        <property type="entry name" value="Prot_Arg_deaminase_cen_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837">
        <property type="entry name" value="PEPTIDYLARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837:SF11">
        <property type="entry name" value="PROTEIN-ARGININE DEIMINASE TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03068">
        <property type="entry name" value="PAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08527">
        <property type="entry name" value="PAD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08526">
        <property type="entry name" value="PAD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001247">
        <property type="entry name" value="Protein-arginine_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110083">
        <property type="entry name" value="Peptidylarginine deiminase Pad4, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein-arginine deiminase (PAD) N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Protein-arginine deiminase (PAD) central" evidence="12">
        <location>
            <begin position="115"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Protein-arginine deiminase C-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001247-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="667" mass="74966" checksum="60939AD44D5095AC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAW4</accession>
    <name>A0A670JAW4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JAW4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022657.1">
        <property type="protein sequence ID" value="ENSPMRP00000021345.1"/>
        <property type="gene ID" value="ENSPMRG00000013865.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000213420"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="137" mass="15219" checksum="F043E01FB1E8C684" modified="2020-06-17" version="1">GVTLREGECGAFQFLLSPCIIFDQWPFRLRGVVVYPHVRASCYSAEEHLLGVQKAPESMLNISSMTKLLLANQSSTWKRRLPSRHSGTYLSTCTLTCFRTVRLAGAGTEQRELTLSQGFKPLTRRSAASRQVLGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEY3</accession>
    <name>A0A670JEY3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Contactin 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CNTN6</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. Contactin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JEY3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024089.1">
        <property type="protein sequence ID" value="ENSPMRP00000022665.1"/>
        <property type="gene ID" value="ENSPMRG00000014662.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160606"/>
    <dbReference type="OMA" id="ICNVTRS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098688">
        <property type="term" value="C:parallel fiber to Purkinje cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000044">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000047">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000052">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000054">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000064">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF38">
        <property type="entry name" value="CONTACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="119"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="302"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="403"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="506"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="608"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="706"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="835" mass="92640" checksum="97209976F3EE19EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFR3</accession>
    <name>A0A670JFR3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114583033</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JFR3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024333.1">
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        <property type="gene ID" value="ENSPMRG00000014866.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244828"/>
    <dbReference type="OMA" id="FAITIMY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <begin position="27"/>
            <end position="53"/>
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    <sequence length="325" mass="36441" checksum="6A8396E19111A6C8" modified="2020-06-17" version="1">MKEKISNESSVSEFLLLEFSAIRELQILHFSLFLALYLATVFGNLLIISAVAFDHHLHTPMYFFLMNLAIQDLGAVSVTIPKSIVNSLMNTRHISYSGCVAQVLLFVFFLSSDISLLTVMSYDRYVAICNPLQYEMLMNKAACKQMVAGVWVAGFLNAVMHTSATFATPFCSNIVNQFFCEIPQLLTLACSNFYLMEIGAIVVSIILVSGCFVFIVVTYVHIFTAVLKIPSVEGRKKAFSTCIPHLVVFSVFFSTACFAYLRPPSKTPSDGDFALTVMYSLVPPMFNPIIYSMRNKEIKNALSKLLGFRKSPLDIFSRVFRFSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JGJ5</accession>
    <name>A0A670JGJ5_PODMU</name>
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        <submittedName>
            <fullName evidence="14">Tripartite motif containing 28</fullName>
        </submittedName>
    </protein>
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        <name evidence="14" type="primary">TRIM28</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="175"/>
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    </feature>
    <feature type="domain" description="B box-type" evidence="13">
        <location>
            <begin position="184"/>
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    <sequence length="864" mass="93984" checksum="8FDB9EFC4DEC75C5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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    </organism>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="15">Acts as a positive regulator of hedgehog signaling and regulates ciliary function.</text>
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            <location evidence="3">Cilium</location>
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        <subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="17">
        <location>
            <begin position="47"/>
            <end position="246"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKS0</accession>
    <name>A0A670JKS0_PODMU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSPMRG00000016571.1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC100362216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35675:SF1">
        <property type="entry name" value="RIKEN CDNA 2810459M11 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="314" mass="33490" checksum="4556044E7AC07B79" modified="2020-06-17" version="1">MDLVPKRLTSTFFVPVASLQASKAFEEATTVAKILARLLGHSEEQGARQMRPGRTHLAGAPRAHGQPRPSARRFVGTRSMVLLAGEPWGAESGQQVLSSFAHHVLPTTGGGSQEAPGAEPTEKAQQQQQQQQQLGTQSPPCTSSVAPSGQLTFFLCRAASLRERAARLREVLQGVRDQSRGSPAALVGVIVQPRPEEEYEALSRLEELLREVFEVEGTCSMEIHTAVFAPGRPDGALELRRVGRRSGYARGGALHRLQNAGAAQASCCGTRCLWACAQGRPALAKPGPVSPGTDKCPPMASLVLIPRKACLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLV7</accession>
    <name>A0A670JLV7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="12">6.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GTP-specific succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="12">G-SCS</shortName>
            <shortName evidence="12">GTPSCS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Succinyl-CoA synthetase beta-G chain</fullName>
            <shortName evidence="12">SCS-betaG</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">SUCLG2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10 12">GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.4" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A670JLV7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025425.1">
        <property type="protein sequence ID" value="ENSPMRP00000023962.1"/>
        <property type="gene ID" value="ENSPMRG00000015512.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010170"/>
    <dbReference type="OMA" id="KQMIGNR"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045244">
        <property type="term" value="C:succinate-CoA ligase complex (GDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03221">
        <property type="entry name" value="Succ_CoA_betaG_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034722">
        <property type="entry name" value="Succ_CoA_betaG_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="15">
        <location>
            <begin position="40"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="14">
        <location>
            <begin position="308"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="375"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="12">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="12">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="442" mass="47550" checksum="25F1B3F70C547B40" modified="2020-06-17" version="1">MASPMASQAGTALRDLALLRASLLARRSPAVQLAPRRWLNLQEYQSKKLMADHGVTVQRFFVADTANDALEAAKRLNATEIVLKAQILAGGRGKGVFSSGLKGGVHLTKDPKVVGELAEQMIGYNLTTKQTPKGGVKVQKVMVAEALDISRETYFAILMDRACNGPVLVGSPQGGVDIEEVAAKSPELIFKEEIDIFEGVKDLQAQRLAENLGFKGPLQQQAADQIKKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKEIFAMDDKSENEPIENEAAHYDLKYIGLDGNIACFVNGAGLAMATCDIISLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKGINAKDVSQVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVHEAKRILTESGLPITAASDLEDAAKKAVASVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JMF9</accession>
    <name>A0A670JMF9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JMF9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027179.1">
        <property type="protein sequence ID" value="ENSPMRP00000025606.1"/>
        <property type="gene ID" value="ENSPMRG00000016588.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271821"/>
    <dbReference type="OMA" id="TSWCKAK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015095">
        <property type="entry name" value="AlkB_hom8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09004">
        <property type="entry name" value="ALKBH8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="519" mass="58432" checksum="0D9CFF76E6A5143C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JML2</accession>
    <name>A0A670JML2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NDUFS4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Mitochondrion inner membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JML2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027872.1">
        <property type="protein sequence ID" value="ENSPMRP00000026268.1"/>
        <property type="gene ID" value="ENSPMRG00000016996.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013835"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072593">
        <property type="term" value="P:reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051591">
        <property type="term" value="P:response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="261" mass="28120" checksum="5A1FCC3EB25770C4" modified="2020-06-17" version="1">SQREWFPNRHVRDGAGTICTIPSLPHLTPPTPLTLSSCLKLAPPSSPAASLCSRLSWQVVTAAAAAAAAIHLLLPLPSPASRFSRDGGGLSLAAPRLRSSCSHQHGGGAASAGALNVSGCGGEALGARGRERSGSRCLHRRPRAQDISPLTGVPEEHIKTRKVHIFVPARNAMQAGVNNTKKWKIEFDTRERWENPLMGWASSADPLSNVLMTFSTKEAAIAFAEKNGWSYDVQEQRIPKPKSKSYGANFSWNKRTRVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNE9</accession>
    <name>A0A670JNE9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neurofilament light polypeptide-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114604492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028600456.1">
        <property type="nucleotide sequence ID" value="XM_028744623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JNE9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026980.1">
        <property type="protein sequence ID" value="ENSPMRP00000025415.1"/>
        <property type="gene ID" value="ENSPMRG00000016452.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604492"/>
    <dbReference type="KEGG" id="pmua:114604492"/>
    <dbReference type="GeneTree" id="ENSGT00940000165724"/>
    <dbReference type="OMA" id="DWYRTKF"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099160">
        <property type="term" value="C:postsynaptic intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099184">
        <property type="term" value="F:structural constituent of postsynaptic intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033693">
        <property type="term" value="P:neurofilament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050405">
        <property type="entry name" value="Intermediate_filament"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652">
        <property type="entry name" value="GLIAL FIBRILLARY ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652:SF4">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
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    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="75"/>
            <end position="394"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="313"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="405" mass="45487" checksum="91E5D44CEFC6FC68" modified="2020-06-17" version="1">MDSEGFGWRKPWEDYRGGGGGAARSVRVSFCSPVPRRSARLSASALGPLTDPLERLDLAQVSNLNAELLGLRAQEKEQLVDLNDRFATYIERVRDLEHRNRALLLELEALRRQQRTPARLPQLYQQEARALRALLDAEAGDKARLEAERDRLRLTCGQLRERCAQEARRRLDAEETLSRVREEAARAALATCDADGAAGSLRAELAFLQKLLEEERAELVAQAELAAATRVAVEGAPGAAGAAARPDISAALRDIRSQYESLAAKNMQAAEEWYRSKFASVAELASRNQEAVRSIRQETVEYRRLLQTRSAEIETLRGAIDSLHKQLESLEGQQGAEVARCQERVAELEQEISEAKEEMARYMREYQELLNVKMALDIEIAAYRKLLEGEEMWWTSSSSLPPLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPC6</accession>
    <name>A0A670JPC6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription cofactor HES-6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114597770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028586842.1">
        <property type="nucleotide sequence ID" value="XM_028731009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JPC6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026329.1">
        <property type="protein sequence ID" value="ENSPMRP00000024812.1"/>
        <property type="gene ID" value="ENSPMRG00000016038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597770"/>
    <dbReference type="KEGG" id="pmua:114597770"/>
    <dbReference type="GeneTree" id="ENSGT00940000164578"/>
    <dbReference type="OMA" id="HNNPRMG"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor HES-1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Orange_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="9">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="212" mass="24163" checksum="6C60E601889070E5" modified="2020-06-17" version="1">MTATTLASCVQKLSNTKEERKLRKPLIERKRRERINNCLDQLKETVVGAFRLDQSKLEKADILEMTVKHLQNIQNSKVMADSKMGLEAQQRYSTGYIQCMHEVHNLLLTCEWMDKTLGARLLNHLLKSLPRSSEETCKADLSSTTSGNSTGSNQSQDQFQPTEDKSGLKKPFQPQTPLHCNQRESPPPSQILQSHFAHNGINMGSLDMWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPH3</accession>
    <name>A0A670JPH3_PODMU</name>
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        <recommendedName>
            <fullName evidence="4">Chemokine interleukin-8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JPH3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027930.1">
        <property type="protein sequence ID" value="ENSPMRP00000026326.1"/>
        <property type="gene ID" value="ENSPMRG00000017027.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240952"/>
    <dbReference type="OMA" id="MDASPCC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048020">
        <property type="term" value="F:CCR chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070098">
        <property type="term" value="P:chemokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048245">
        <property type="term" value="P:eosinophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00272">
        <property type="entry name" value="Chemokine_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF103">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="4">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="82" mass="9343" checksum="71C9335865525ED7" modified="2020-06-17" version="1">IQTTYDHVVKTDACLLQLPGGMDASPCCPRYNHKPFPRSIVKSFFRTSSHCNRPAVVFHLKKKNRKACADPSKEWVQKTLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPW3</accession>
    <name>A0A670JPW3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JPW3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026548.1">
        <property type="protein sequence ID" value="ENSPMRP00000025022.1"/>
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    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
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    </dbReference>
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        <property type="entry name" value="RT_POL"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="143"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="616" mass="68010" checksum="195D49C75E1C4BE9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQ46</accession>
    <name>A0A670JQ46_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CLK2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670JQ46"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027602.1">
        <property type="protein sequence ID" value="ENSPMRP00000026010.1"/>
        <property type="gene ID" value="ENSPMRG00000016834.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154947"/>
    <dbReference type="OMA" id="RHHIQSF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14215">
        <property type="entry name" value="PKc_CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000145">
        <property type="entry name" value="Dual specificity protein kinase CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000061">
        <property type="entry name" value="Dual specificity protein kinase CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="229"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026010.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="565" mass="67062" checksum="77A5D9364C49C786" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQ85</accession>
    <name>A0A670JQ85_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DEAD box protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DDX4</name>
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    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX4/VASA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670JQ85"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028176.1">
        <property type="protein sequence ID" value="ENSPMRP00000026561.1"/>
        <property type="gene ID" value="ENSPMRG00000017153.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157507"/>
    <dbReference type="OMA" id="NRXSNND"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18052">
        <property type="entry name" value="DEADc_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="322"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="533"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="94"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="738" mass="80565" checksum="89C25362A5D827EF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQL3</accession>
    <name>A0A670JQL3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein S100</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S100 calcium-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">S100Z</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the S-100 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JQL3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027791.1">
        <property type="protein sequence ID" value="ENSPMRP00000026190.1"/>
        <property type="gene ID" value="ENSPMRG00000016943.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161125"/>
    <dbReference type="OMA" id="MDSMIRI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000044">
        <property type="entry name" value="Protein S100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001751">
        <property type="entry name" value="S100/CaBP7/8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639:SF134">
        <property type="entry name" value="PROTEIN S100-A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639">
        <property type="entry name" value="S100 CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00303">
        <property type="entry name" value="S100_CABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="100" mass="11391" checksum="03AC9B129D8CA41C" modified="2020-06-17" version="1">MPTLLEGAMDTLIKVFHHYSGKEGDKYKLNKGELKELLTSELTDFLSCQKDPQLVDKIMQDLDSNKDNEVDFNEFVVLVAALTVACNDFFEEKEENTNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JQQ4</accession>
    <name>A0A670JQQ4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670JQQ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027834.1">
        <property type="protein sequence ID" value="ENSPMRP00000026230.1"/>
        <property type="gene ID" value="ENSPMRG00000016977.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="606" mass="70221" checksum="3AE1342EA501105B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUX7</accession>
    <name>A0A670JUX7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha/beta hydrolase domain-containing protein 17C</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ABHD17C</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic density membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the AB hydrolase superfamily. ABHD17 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670JUX7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030796.1">
        <property type="protein sequence ID" value="ENSPMRP00000029028.1"/>
        <property type="gene ID" value="ENSPMRG00000018765.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159424"/>
    <dbReference type="OMA" id="YSEREKX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902817">
        <property type="term" value="P:negative regulation of protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905668">
        <property type="term" value="P:positive regulation of protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000008">
        <property type="entry name" value="Alpha/beta hydrolase domain-containing protein 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF55">
        <property type="entry name" value="ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="17">
        <location>
            <begin position="109"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="281" mass="30831" checksum="6D6039B50F71D873" modified="2020-06-17" version="1">MPEQGPRMNGFSLGELCWLFCCPPCPSRIAAKLAFLPPEPTYTVMQPEQQEGGAAAVGTPTGSCSLHLTERADWQYSQRELDAVEVFFSRTARDNRLGCMFVRCAPSSRYTLLFSHGNAVDLGQMCSFYIGLGSRINCNVFSYDYSGYGVSTGKPSEKNLYADIDAAWQALRTRYGVSPENIILYGQSIGTVPTVDLASRYECAAVILHSPLMSGLRVAFPDTRKTYCFDAFPSIDKISKVTSPVLVIHGTEDEVIDFSHGLAMGNFSFSDTGIAQNMQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVF5</accession>
    <name>A0A670JVF5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CSGALNACT1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A670JVF5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030159.1">
        <property type="protein sequence ID" value="ENSPMRP00000028431.1"/>
        <property type="gene ID" value="ENSPMRG00000018359.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244968"/>
    <dbReference type="OMA" id="DSKHEFR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047237">
        <property type="term" value="F:glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF19">
        <property type="entry name" value="CHONDROITIN SULFATE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHGN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="323" mass="36885" checksum="798029DA1E6FC1BB" modified="2020-06-17" version="1">MVRRGIVAWLPRVAVLLVVLCCAVSVLYMLACTPRGDNQQLAFPRANSPTGKEEYQAILQEREEHHWDYISSLKRQIAELKDELQERSQQLKNMQGHSTDSLGVGIDRRDPEKPQKALLQFLHSQVDKAEVHTGMKLPNEYAAVPFESFTLHRVYQLEMGLTRHPEEKPVRKDKRDELAEAVELGLETLNSPERNSNTNRRAYSPSDFIEGLRRIERDKGTLYELIFKGGKAYEFERIVLFRPFGPIMKVKNENLNMADTLINVIVPLAKRASKFQQFMQNFRLVKLHALTASPQLCPNTSSLVIIAFLTYTVRGKGKGTPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWT0</accession>
    <name>A0A670JWT0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protocadherin-19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PCDH19</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JWT0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031546.1">
        <property type="protein sequence ID" value="ENSPMRP00000029743.1"/>
        <property type="gene ID" value="ENSPMRG00000019237.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159162"/>
    <dbReference type="OMA" id="RCWMPRG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Protocadherin 19"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protocadherin-19 isoform X2"/>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
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        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN-87A"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF40">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025450896" description="Protocadherin-19" evidence="17">
        <location>
            <begin position="22"/>
            <end position="1184"/>
        </location>
    </feature>
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        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="28"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="130"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="239"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="350"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="454"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="569"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="851"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1057"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072300"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130453" checksum="4CA0E1B050123D37" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JX17</accession>
    <name>A0A670JX17_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="392" mass="44713" checksum="335D0F07D6CAA8D9" modified="2020-06-17" version="1">SKSKNELGMAEGGHSYTSIEELKNVWIPYSIKMKLSKNKELEVYNWDESTELTVLDDQESTYVYDLMATIVHILDSRTGGSLVGHIKVGETYHQRKEGVTHQQWYLFNDFLIEPVDKCEAVQFDMSWKVPAILYYVRRNLHSKYNLTIKNPIEASVLLAEASLARKQRKCHATFIPLMLNEMPQVGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGVPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLHFRVINIMVTASVIDTVYLFHMPRKRMISLRFLAWYFLGQYRTIHSVPIHLPASLNSLPRIPSSTVISFASWSRALRKLDWLQPEPGPFQHWLRPGGTFCHKRLGPCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0R2</accession>
    <name>A0A670K0R2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PFN1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K0R2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030299.1">
        <property type="protein sequence ID" value="ENSPMRP00000028562.1"/>
        <property type="gene ID" value="ENSPMRG00000018456.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153664"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005454">
        <property type="entry name" value="Profilin1/2/3_vertebrate"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13936">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13936:SF14">
        <property type="entry name" value="PROFILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01639">
        <property type="entry name" value="PROFILINMAML"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="330" mass="34100" checksum="489DBB624B032DC3" modified="2020-06-17" version="1">MQRGQSIPRMSPPSPDGAPPGSQGGSCTWGRRERRACARVCVVCAPGLPAPLPALGRPLPPRPAPSPPCARSPLRSSARSARAAARATSGSRVPFFPRGPLQTEASRPPRPGFCIRAQQQQPRLLLLLRARLHPSASPSAAMSGWNSYIDNLMADDTCQDAAIVGYKDVPSVWAAAPGKTFANITPAEVNILVGKDRSNLFVNGLTLGGQKCSVIRDSLHTDGECTMDLRTKSTGGAPTFNITAAMTAKSELTGGAPPTSPLPKSPCSCPSLAEGTACILSPNSCGGFFWGGPSASNGGGGQLLLNPAPGRAEKAASVLPRQLQGVVNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K1F7</accession>
    <name>A0A670K1F7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K1F7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030525.1">
        <property type="protein sequence ID" value="ENSPMRP00000028777.1"/>
        <property type="gene ID" value="ENSPMRG00000018600.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000288025"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="71" mass="8049" checksum="EDEBDBFE7B2E9813" modified="2020-06-17" version="1">MLSLWVNQTFSTTVHCVCGRKYKTRAACVCWEARRQEESSPVCFCSSSRHHICGIVVWGMPISAVLQKCQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K225</accession>
    <name>A0A670K225_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glycerol-3-phosphate acyltransferase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GPAT4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028597356.1">
        <property type="nucleotide sequence ID" value="XM_028741523.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028597357.1">
        <property type="nucleotide sequence ID" value="XM_028741524.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028597358.1">
        <property type="nucleotide sequence ID" value="XM_028741525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K225"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032672.1">
        <property type="protein sequence ID" value="ENSPMRP00000030806.1"/>
        <property type="gene ID" value="ENSPMRG00000019960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602837"/>
    <dbReference type="KEGG" id="pmua:114602837"/>
    <dbReference type="CTD" id="137964"/>
    <dbReference type="GeneTree" id="ENSGT01030000234574"/>
    <dbReference type="OMA" id="ANHTTVM"/>
    <dbReference type="OrthoDB" id="10051137at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046339">
        <property type="term" value="P:diacylglycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002071">
        <property type="term" value="P:glandular epithelial cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040014">
        <property type="term" value="P:regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF37">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="241"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="455" mass="52010" checksum="9DA48B21F184EF39" modified="2020-06-17" version="1">MFLLLPFDSLVVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRRLYMRTLLQIFQWATLRIERGAKEKKHPLYKPYVNGIIAKEPTSLEEEIKEIRRSGSNKALDAPEFELSDIFYFCRKGIETIMDDEVTKRFSAEELQSWNLLSRTNYNFHYISLRLTVLWGLGVLIRYCFLLPLRVALAFTGISLLVTGTTMVGYLPNGRCKEFLSRHVHLMCYRICVRALTAIITYHHRENRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHLVAKRLSEHAHDKNKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAFFNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREPDEDAVQFANRVKSAIARQGGLVDLLWDGGLKREKVKDTFKEEQQKLYSKMVVGNHEDRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2B5</accession>
    <name>A0A670K2B5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SIK3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030860.1">
        <property type="protein sequence ID" value="ENSPMRP00000029092.1"/>
        <property type="gene ID" value="ENSPMRG00000018695.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157259"/>
    <dbReference type="OMA" id="HRYIYKD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060351">
        <property type="term" value="P:cartilage development involved in endochondral bone morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035108">
        <property type="term" value="P:limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14410">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="708"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1004"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1144"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1216"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="734"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="748"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1010"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1168"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1285" mass="143122" checksum="D492B9773DDF182E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K2F7</accession>
    <name>A0A670K2F7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MPV17 mitochondrial inner membrane protein like 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K2F7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032824.1">
        <property type="protein sequence ID" value="ENSPMRP00000030946.1"/>
        <property type="gene ID" value="ENSPMRG00000020044.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160620"/>
    <dbReference type="OMA" id="KARAHMF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF8">
        <property type="entry name" value="MPV17-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21072" checksum="DB665BD08E8D29B0" modified="2020-06-17" version="1">YGLCQITQTVSILNAELPSLQESCDILTSILQCFKGLKEQATLSSGKARAHMFAIGCSMGPLYLWLNCTLPTKVFIDQIMASPALGVWYFLGMGSLAGQRLDQSWQELEDNFWEFYKMDWYVWPPVQLINFLLLPAAYWVLYMNVITLDWNTYLSYLKHRPKHPSLSVEKNDEADTVEIEMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3F8</accession>
    <name>A0A670K3F8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PLCL2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670K3F8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033210.1">
        <property type="protein sequence ID" value="ENSPMRP00000031311.1"/>
        <property type="gene ID" value="ENSPMRG00000020299.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155660"/>
    <dbReference type="OMA" id="LRENMQX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050811">
        <property type="term" value="F:GABA receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002322">
        <property type="term" value="P:B cell proliferation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050859">
        <property type="term" value="P:negative regulation of B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16223">
        <property type="entry name" value="EFh_PRIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08597">
        <property type="entry name" value="PI-PLCc_PRIP_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000025">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000017">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000001">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028382">
        <property type="entry name" value="PLCL2_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF84">
        <property type="entry name" value="INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="137"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="614"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="730"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1000" mass="112095" checksum="298E3D3E3BED1A42" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3W8</accession>
    <name>A0A670K3W8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Cholesteryl ester transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CETP</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:43352"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl (9Z,12Z)-octadecadienoate(out)</text>
            <dbReference type="Rhea" id="RHEA:43356"/>
            <dbReference type="ChEBI" id="CHEBI:41509"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-octadecenoate)(out)</text>
            <dbReference type="Rhea" id="RHEA:43348"/>
            <dbReference type="ChEBI" id="CHEBI:46898"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Secreted</location>
        </subcellularLocation>
        <text evidence="17">Secreted in plasma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028595102.1">
        <property type="nucleotide sequence ID" value="XM_028739269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K3W8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032158.1">
        <property type="protein sequence ID" value="ENSPMRP00000030329.1"/>
        <property type="gene ID" value="ENSPMRG00000019613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601773"/>
    <dbReference type="KEGG" id="pmua:114601773"/>
    <dbReference type="CTD" id="1071"/>
    <dbReference type="GeneTree" id="ENSGT01100000263546"/>
    <dbReference type="OMA" id="WFSDHVL"/>
    <dbReference type="OrthoDB" id="9940758at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017129">
        <property type="term" value="F:triglyceride binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034375">
        <property type="term" value="P:high-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034374">
        <property type="term" value="P:low-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032376">
        <property type="term" value="P:positive regulation of cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001140">
        <property type="term" value="P:positive regulation of phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010874">
        <property type="term" value="P:regulation of cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043691">
        <property type="term" value="P:reverse cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070328">
        <property type="term" value="P:triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034197">
        <property type="term" value="P:triglyceride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034372">
        <property type="term" value="P:very-low-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00025">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.10:FF:000002">
        <property type="entry name" value="Cholesteryl ester transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.20.10:FF:000002">
        <property type="entry name" value="Cholesteryl ester transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017130">
        <property type="entry name" value="Cholesteryl_ester_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47616">
        <property type="entry name" value="CHOLESTERYL ESTER TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47616:SF1">
        <property type="entry name" value="CHOLESTERYL ESTER TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037185">
        <property type="entry name" value="Cholesteryl_ester_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="12 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 17" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <keyword evidence="15 17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025721570" description="Cholesteryl ester transfer protein" evidence="17">
        <location>
            <begin position="21"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="19">
        <location>
            <begin position="33"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="20">
        <location>
            <begin position="274"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR037185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037185-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="499" mass="55830" checksum="2D8D32FCC7BCCE5A" modified="2020-06-17" version="1">MARILIMLVSLLSSSLPCSAEPSSYSDTSVVFRMTKPAVLVLNQKTAHVIQTAFQHADYPDIKGEKSVRFLGKIAYGLKNIHIGELMTENTTVDLKEDDAIDIGIQNVSASFRGTLSYGYVGGWLVKLIHSIDFEIESSIDLQINVKLLSDDGRVIVDTSDCYLTFHKLTLHLQGDKDPGWLKQLFTNFISFTLKLVLKNQVCKEINYISQLLADYVHETSANFLKDGDIGVDISVTASPAIKANYIESHHKGLVVYQNHSGIFHDSAFTPSLLTDSKMVYFWFSDQVLNSVALATFLDKRLELTLTGEKLKEMFEIEELKTQQEIVQKIFRGASYNDSLAKVWSLDPPQIILQPEGTIVKSSVAVELSVPLQGEGPPSVALYFEKEVTVTVQASYMQKNLYLHHSEAMIEIKKLKRAADIAVNDETLKHILEKIVSVAGIPEVVSRFERDISSLLSSKGLNHFDIIDPEIVTKKGHLILQMDFGFPHHLLVEFLKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4A5</accession>
    <name>A0A670K4A5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloprotease TIKI</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">TRAB domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TRABD2A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="13">Divalent metal cations. Mn(2+) or Co(2+).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TIKI family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028567929.1">
        <property type="nucleotide sequence ID" value="XM_028712096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K4A5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031555.1">
        <property type="protein sequence ID" value="ENSPMRP00000029752.1"/>
        <property type="gene ID" value="ENSPMRG00000019240.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587609"/>
    <dbReference type="KEGG" id="pmua:114587609"/>
    <dbReference type="CTD" id="129293"/>
    <dbReference type="GeneTree" id="ENSGT00940000165000"/>
    <dbReference type="OMA" id="HHHDLER"/>
    <dbReference type="OrthoDB" id="10040378at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14789">
        <property type="entry name" value="Tiki"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040230">
        <property type="entry name" value="TIKI1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120">
        <property type="entry name" value="METALLOPROTEASE TIKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120:SF7">
        <property type="entry name" value="METALLOPROTEASE TIKI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025473420" description="Metalloprotease TIKI" evidence="14">
        <location>
            <begin position="23"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="514" mass="59281" checksum="D6D46926E5A2CB88" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4N5</accession>
    <name>A0A670K4N5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">IRF tryptophan pentad repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K4N5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031696.1">
        <property type="protein sequence ID" value="ENSPMRP00000029887.1"/>
        <property type="gene ID" value="ENSPMRG00000019326.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159063"/>
    <dbReference type="OMA" id="DACIFRA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00103">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000065">
        <property type="entry name" value="Interferon regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019817">
        <property type="entry name" value="Interferon_reg_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF22">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00267">
        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00601">
        <property type="entry name" value="IRF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="9">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="133" mass="15802" checksum="4AF3A4BE311E044B" modified="2020-06-17" version="1">MPVERMRMRPWLEEQINSNKIPGLKWLNEEKMIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKFQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSKKGKGEEHYKMKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K537</accession>
    <name>A0A670K537_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calsequestrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CASQ1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Sarcoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Sarcoplasmic reticulum membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the calsequestrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K537"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033209.1">
        <property type="protein sequence ID" value="ENSPMRP00000031310.1"/>
        <property type="gene ID" value="ENSPMRG00000020298.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000019377"/>
    <dbReference type="OMA" id="WMEMDNE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033018">
        <property type="term" value="C:sarcoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051281">
        <property type="term" value="P:positive regulation of release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014809">
        <property type="term" value="P:regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03074">
        <property type="entry name" value="PDI_b'_Calsequestrin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03066">
        <property type="entry name" value="PDI_b_Calsequestrin_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03065">
        <property type="entry name" value="PDI_b_Calsequestrin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000031">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000033">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000047">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001393">
        <property type="entry name" value="Calsequestrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041860">
        <property type="entry name" value="Calsequestrin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018233">
        <property type="entry name" value="Calsequestrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041858">
        <property type="entry name" value="Calsequestrin_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041859">
        <property type="entry name" value="Calsequestrin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10033">
        <property type="entry name" value="CALSEQUESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10033:SF14">
        <property type="entry name" value="CALSEQUESTRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01216">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00312">
        <property type="entry name" value="CALSEQUESTRN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00863">
        <property type="entry name" value="CALSEQUESTRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00864">
        <property type="entry name" value="CALSEQUESTRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="440" mass="50170" checksum="72DB6A5ECB54BDA6" modified="2020-06-17" version="1">MAIRKGRQISALERGRPGQGEALVINQRQVVQSGSLGLPLPGRSGRMKWLGVALVALLLAAFGPLGRGEDGLDFPEYDGIDRVIDVNAKNYKNVLKKYEILALLYHEPIGDDKASQKQFELEELILELAAQVLEEKGVGFGLVDAEKDAAVAKKLGLGEEDSVYVFKDDEIIEYDGEFSADTLVEFILDVMEDPVEFIEGEHELEAFENVEDEPKLIGYFKNEDSEHFKAYEDAAEEFHPYIDFYATFDSKVAKKLSLKLNEIDYYEPFMEEPVTIPDKPNSEEEIVQFLEEHKRPTLRKLQPESMYETWEDDIDGIHIVAFAEEDDPDGYEFLEILKDVAQDNTDNPDLSIIWIDPEDFPLLIPYWEKTFDIDLSRPQIGVVNVTDADSIWLEMDDEDDLPSTEELEDWIEDVLEGEINTEDDDDDDDDDDDDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7S1</accession>
    <name>A0A670K7S1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="15">PPIase</shortName>
            <ecNumber evidence="15">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PPIH</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="15"/>
    <dbReference type="RefSeq" id="XP_028596239.1">
        <property type="nucleotide sequence ID" value="XM_028740406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K7S1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033583.1">
        <property type="protein sequence ID" value="ENSPMRP00000031659.1"/>
        <property type="gene ID" value="ENSPMRG00000020510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602327"/>
    <dbReference type="KEGG" id="pmua:114602327"/>
    <dbReference type="CTD" id="10465"/>
    <dbReference type="GeneTree" id="ENSGT00940000154721"/>
    <dbReference type="OMA" id="SVWGQVI"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071001">
        <property type="term" value="C:U4/U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045070">
        <property type="term" value="P:positive regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000017">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="16">
        <location>
            <begin position="14"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="177" mass="19191" checksum="1E98E48CBD9BF1BA" modified="2020-06-17" version="1">MAVLASNPNNPVVFFDVTIGGQEVGRMKVELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLKHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIVDGLLVMRKIENVPTGPNNKPKLPVVIAQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K989</accession>
    <name>A0A670K989_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADPH oxidase activator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NOXA1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K989"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035382.1">
        <property type="protein sequence ID" value="ENSPMRP00000033351.1"/>
        <property type="gene ID" value="ENSPMRG00000021623.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063843"/>
    <dbReference type="OMA" id="VLYRMVA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016176">
        <property type="term" value="F:superoxide-generating NADPH oxidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010310">
        <property type="term" value="P:regulation of hydrogen peroxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060263">
        <property type="term" value="P:regulation of respiratory burst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF4">
        <property type="entry name" value="NADPH OXIDASE ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="340"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="399" mass="44994" checksum="4734B1EDC976ED66" modified="2020-06-17" version="1">ISPAVKKHRSKKRNLATLTLFFCLQAFDRSISKDNCLAVGFFQRGYAYLLLERYEEALNDFRLALLHLRKNPCIDYKQLGLKFVLCAWEVAYNTAAAHCHLGQWQDAQQTLKEAARETPKGQIHHLDSALKQVQEHLFLEPRSVPQGEIFKPPKKDVEELEEKDFLGQAKVISSAFEEDCGIRFHDPQPQKGSSGIPPPPGKEPPTLPCERQNIQKSAPAKEDDGRADMNITGQNTSLEDLSSSGEAGDITNEFILLKIHTSYSVKVKMSPAPSLADFRNLLQEECCQQATQMSVRYKISGSDELIPVSNDEELRNIWQSMEGGQLTLWCQAQRDTTSRPVLYHMTACHPYTAQGQEDLSFKEGDKLEILSEVNEEWLEGRCNGTTGIFPKCFAVRECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K995</accession>
    <name>A0A670K995_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein phosphatase 1 regulatory inhibitor subunit 16B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">CAAX box protein TIMAP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">TGF-beta-inhibited membrane-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PPP1R16B</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="16">Interacts with PPP1CA, PPP1CB and MSN. Interacts (via its fourth ankyrin repeat) with the mature dimeric form of RPSA/LAMR1. Interacts with EEF1A1. Interacts with PTEN. Interacts with ECE1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028590826.1">
        <property type="nucleotide sequence ID" value="XM_028734993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K995"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034908.1">
        <property type="protein sequence ID" value="ENSPMRP00000032905.1"/>
        <property type="gene ID" value="ENSPMRG00000021338.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599546"/>
    <dbReference type="CTD" id="26051"/>
    <dbReference type="GeneTree" id="ENSGT00940000154090"/>
    <dbReference type="OMA" id="LLCSPPM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017020">
        <property type="term" value="F:myosin phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061028">
        <property type="term" value="P:establishment of endothelial barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903670">
        <property type="term" value="P:regulation of sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000105">
        <property type="entry name" value="protein phosphatase 1 regulatory inhibitor subunit 16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000079">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017417">
        <property type="entry name" value="Pase-1_reg_su_16AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF31">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038159">
        <property type="entry name" value="PP1_16AB_vert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 21" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="propeptide" id="PRO_5036524258" description="Removed in mature form" evidence="20">
        <location>
            <begin position="569"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="21">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="21">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="21">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="21">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="modified residue" description="Cysteine methyl ester" evidence="20">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-palmitoyl cysteine" evidence="20">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-farnesyl cysteine" evidence="20">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="571" mass="63856" checksum="72740BA7E14CD1FE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KA52</accession>
    <name>A0A670KA52_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KA52"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033622.1">
        <property type="protein sequence ID" value="ENSPMRP00000031697.1"/>
        <property type="gene ID" value="ENSPMRG00000020538.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000169116"/>
    <dbReference type="OMA" id="YPFSRRY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="190" mass="20788" checksum="3DACA4E88B912EAB" modified="2020-06-17" version="1">MNAERRVRAWAEAQRARGRRVALVTSGGTQVPLEARAVRFLENFSSGRRGAASAERLVRAGYGVCFLYRTRSAFPWARALPLSGPALLDVLRVHDDDAGGQRVLVDCSGSALPDLVPALLAYHRAKEEDALLVLEFTGLVEYLALLRAAARALAPLGKRRWWEVGGKEGVVPAPARLPQYCRHEVTAVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAZ6</accession>
    <name>A0A670KAZ6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">snRNA-activating protein complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Small nuclear RNA-activating complex polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SNAPC3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028568388.1">
        <property type="nucleotide sequence ID" value="XM_028712555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KAZ6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036037.1">
        <property type="protein sequence ID" value="ENSPMRP00000033976.1"/>
        <property type="gene ID" value="ENSPMRG00000022042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587794"/>
    <dbReference type="KEGG" id="pmua:114587794"/>
    <dbReference type="CTD" id="6619"/>
    <dbReference type="GeneTree" id="ENSGT00390000005708"/>
    <dbReference type="OMA" id="AHRDDCL"/>
    <dbReference type="OrthoDB" id="46583at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="388" mass="44755" checksum="58FE71C222015619" modified="2020-06-17" version="1">MAGCSSSSNGSASRRSDIPEYETPELNTRLLHVGTFGDLWKERLREAELSLQPEAPADEDDAALVQELGCTPEIAAELRAVCRIDALKGSGKEDTEVIPEDTSLITLRIRQKALTRRKETITVDRACRQETFIYEMESQAIGKRPKDPENLVKEGQLLLTLNIFYPVILQKHKLRKPYQTMLVLGSQKLTELRDSISCVSDFQIGGEFSSHPDQAPENISKDLYKSAFFYFEGVFYDDRRYPECRDLSRTIIEWAESRERGYENLQAAKMEDFTFNDLNIKIGFPYLYCHQGDCEHIVIITDIRLIHRDDCLDRSLYPLLTKKHWLWTKKCFVCKMYTARWVTNDDSLAPEDPSFFCDVCFRMLHYDAEGKKLGEFLAYPYVDPGIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBK2</accession>
    <name>A0A670KBK2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KBK2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036253.1">
        <property type="protein sequence ID" value="ENSPMRP00000034176.1"/>
        <property type="gene ID" value="ENSPMRG00000022182.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006172"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10575" checksum="90A9EF1485ED009F" modified="2020-06-17" version="1">PKTDHFLFLVSSHQLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSRTVYNVHSDNKLSEMLSLFEKGVTCLNNTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KC18</accession>
    <name>A0A670KC18_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tudor domain containing 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TDRD7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDRD7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KC18"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035178.1">
        <property type="protein sequence ID" value="ENSPMRP00000033159.1"/>
        <property type="gene ID" value="ENSPMRG00000021504.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000035189.1">
        <property type="protein sequence ID" value="ENSPMRP00000033170.1"/>
        <property type="gene ID" value="ENSPMRG00000021504.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000035204.1">
        <property type="protein sequence ID" value="ENSPMRP00000033185.1"/>
        <property type="gene ID" value="ENSPMRG00000021504.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000035218.1">
        <property type="protein sequence ID" value="ENSPMRP00000033199.1"/>
        <property type="gene ID" value="ENSPMRG00000021504.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000035234.1">
        <property type="protein sequence ID" value="ENSPMRP00000033212.1"/>
        <property type="gene ID" value="ENSPMRG00000021504.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000035251.1">
        <property type="protein sequence ID" value="ENSPMRP00000033227.1"/>
        <property type="gene ID" value="ENSPMRG00000021504.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000035271.1">
        <property type="protein sequence ID" value="ENSPMRP00000033247.1"/>
        <property type="gene ID" value="ENSPMRG00000021504.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00890000139482"/>
    <dbReference type="OMA" id="LYQLENW"/>
    <dbReference type="OrthoDB" id="10034606at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070306">
        <property type="term" value="P:lens fiber cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002089">
        <property type="term" value="P:lens morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09974">
        <property type="entry name" value="LOTUS_3_TDRD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20428">
        <property type="entry name" value="Tudor_TDRD7_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000065">
        <property type="entry name" value="tudor domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.610:FF:000008">
        <property type="entry name" value="Tudor domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037978">
        <property type="entry name" value="TDRD7_LOTUS_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047448">
        <property type="entry name" value="Tudor_TDRD7_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF14">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="HTH OST-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="10">
        <location>
            <begin position="233"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="10">
        <location>
            <begin position="335"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="9">
        <location>
            <begin position="508"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="9">
        <location>
            <begin position="697"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="853"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1079" mass="120569" checksum="DD65224A47347A15" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KC29</accession>
    <name>A0A670KC29_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KC29"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035964.1">
        <property type="protein sequence ID" value="ENSPMRP00000033905.1"/>
        <property type="gene ID" value="ENSPMRG00000021990.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000258">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000027">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="208" mass="23471" checksum="61BDE0CFE4BFB855" modified="2020-06-17" version="1">GSIHVAKVQQSGNALQRQTQSRGAVEHMSLIHLGVIAFLGLYLMFGYGASLLCNLIGFVYPAYVSIKAIESSTKDDDTTWLTYWVAYGLFSVAEFFSDTFLYWFPFYYAGKCLFLLWCMAPVSWNGSQVLYRNVIRPWFLKHHQTVDSVLSDLGGRAAHVASTVSREGNCVNYGYGFYICGCIVLEFRKLLRERGFGPFEKTTALKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KF32</accession>
    <name>A0A670KF32_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KF32"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038164.1">
        <property type="protein sequence ID" value="ENSPMRP00000036013.1"/>
        <property type="gene ID" value="ENSPMRG00000023266.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154136"/>
    <dbReference type="OMA" id="CEVMEHW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="492" mass="56259" checksum="326F714E8123E83F" modified="2020-06-17" version="1">MQTGDTERAELLNAFFASVFSDKENNARPEEFGANDSAEETQPRITKEIVQEYLASLDVFKYPGPDELHPRVLKEVADVISEPLAVLFENSWRTGEVPADWRRANVVPIFKKGKRENPNNYRPVSLTSIPGKILEQIIKQTVCEHLERNAVITNSQHGFLKNKSCQTYLILFFDRITSLVDEGNAVDVVYLDFSKAFDKVPHDILVKKLVKCGLDYATTQWICNWLTDRTQRVLINGSSSSWRRVTSGVPQGSVLGPVLFNIFINDLDDGLKGILIKFADDTKMGDTWLESSTCEKDLGVLVDHKLDMSQQCDTAAKKANAILGCINRSIASRSREVIVPLYSALVRPHLEYCVQFWAPQFKKDTDKLERVQRRATKMVKGLETMPYEERLRELGMFSLEKRRLRGDMIAMFKYIKGCHVEEGERLFSAAPEKRTRSNGSKLQERRFHLNIRKNFLTVRAVRQWNLLPRSVVESPSLEVFKQRLDNHMSGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGJ3</accession>
    <name>A0A670KGJ3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Forkhead box L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FOXL3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KGJ3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036851.1">
        <property type="protein sequence ID" value="ENSPMRP00000034744.1"/>
        <property type="gene ID" value="ENSPMRG00000022510.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162800"/>
    <dbReference type="OMA" id="RTEGHDK"/>
    <dbReference type="OrthoDB" id="9926427at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000266">
        <property type="entry name" value="Forkhead box protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF211">
        <property type="entry name" value="FORKHEAD BOX PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025472554" evidence="6">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="316" mass="35804" checksum="BADC1A3520A801DD" modified="2020-06-17" version="1">MKPVGLFNLATLCMSLASGRLVPILPVGDHPGSQDCIATGCCIHPSSKVQERPLPHLNRSQKRTRNMFDNTQYPYNCFNYDGDDYPTCSSDEEKRFTRPAYSYIALIAMAIQQSPSNKVTLSGIYDFIMKKFPYYRTNQRAWQNSIRHNLSLNSCFVKVPRTEGNDKGKGNYWSFASGCESMLDLFENGNYRRRRRRKNVKREPRDKRPNGGSDCLQALSPVDSGFPGINSCPGQRVQSQPKALETCELFPNAAASRESLNSSSIGKSDSEIKFSIDYILSSPDPLPVLRSPYHTEDNKYHLLDSQQLVNLQFWTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KHA2</accession>
    <name>A0A670KHA2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromobox 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CBX6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028602542.1">
        <property type="nucleotide sequence ID" value="XM_028746709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KHA2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037133.1">
        <property type="protein sequence ID" value="ENSPMRP00000035019.1"/>
        <property type="gene ID" value="ENSPMRG00000022664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605422"/>
    <dbReference type="KEGG" id="pmua:114605422"/>
    <dbReference type="CTD" id="23466"/>
    <dbReference type="GeneTree" id="ENSGT00940000154405"/>
    <dbReference type="OMA" id="GANRFAC"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18648">
        <property type="entry name" value="CD_Cbx6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000006">
        <property type="entry name" value="Chromobox protein homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033773">
        <property type="entry name" value="CBX7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052458">
        <property type="entry name" value="PcG_PRC1-like_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389:SF4">
        <property type="entry name" value="CHROMOBOX PROTEIN HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17218">
        <property type="entry name" value="CBX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="400" mass="43411" checksum="07B341330F5B6198" modified="2020-06-17" version="1">MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALHIGDVHFSVKPGSSTSSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQSSGVGGGTGIRPPVSPFSETVRIINRKVKPREPKRSRIILNLKVIDKDGKVGSRGGSLARSKIPSRNRVIGKSKKFSESMLRNQIRHMKFGNFPLYNKPSTPVPSLEGKTEAGGSQGASCGLMGSSAYDARSSSSSDCPSPAPHSSSDPDDSPPKLLPETLSPAIPDWRESEVLDLSIPPESAATSKRSPSGGGGQMPSSPSSSDPEQEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCNAEDFEKVAAAGGGGGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIA3</accession>
    <name>A0A670KIA3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MAP2K3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A670KIA3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037507.1">
        <property type="protein sequence ID" value="ENSPMRP00000035379.1"/>
        <property type="gene ID" value="ENSPMRG00000022885.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160875"/>
    <dbReference type="OMA" id="RISCVYK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060048">
        <property type="term" value="P:cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071493">
        <property type="term" value="P:cellular response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035924">
        <property type="term" value="P:cellular response to vascular endothelial growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904784">
        <property type="term" value="P:NLRP1 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043536">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070269">
        <property type="term" value="P:pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031098">
        <property type="term" value="P:stress-activated protein kinase signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06617">
        <property type="entry name" value="PKc_MKK3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000158">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF21">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="65"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="390" mass="44365" checksum="49A6041E8A1F7615" modified="2020-06-17" version="1">MDRKQDPKGSSEKRKVGPKKKRPPLLSMPSANRQSSVPPTPPRNLDSRTFITVGEKNFEVEADDLVSISELGRGAYGVVEKVYHAQSDTTMAVKRIRATVNSQEQKRLVMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKRVLEKKKTIPEDILGKITVSIVRALEHLHSKLSVIHRDVKPSNVLINKQGHVKMCDFGISGYLVDSVAKTLDAGCKPYMAPERINPELNQQGYNVKSDVWSLGITLIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAEHFSQNFVDFTAQCLRKNPAERLSYVELMVSVSSFLLQIWLRVMWCQQGINRIVELEGTTRVINNNNNNNNNTFIYTPPSLARAWCRAANNSRITVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIL0</accession>
    <name>A0A670KIL0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SRPK3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670KIL0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039405.1">
        <property type="protein sequence ID" value="ENSPMRP00000037213.1"/>
        <property type="gene ID" value="ENSPMRG00000023942.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157877"/>
    <dbReference type="OMA" id="MDNVTLC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14218">
        <property type="entry name" value="STKc_SRPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000105">
        <property type="entry name" value="SRSF protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000163">
        <property type="entry name" value="SRSF protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF20">
        <property type="entry name" value="SRSF PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="79"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="557" mass="62125" checksum="CD5A15AC8F095339" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKB0</accession>
    <name>A0A670KKB0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KKB0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038305.1">
        <property type="protein sequence ID" value="ENSPMRP00000036144.1"/>
        <property type="gene ID" value="ENSPMRG00000023356.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="CGDELEM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000005">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001808">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003000">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000250">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="14">
        <location>
            <begin position="52"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="160"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="512" mass="58689" checksum="87B43517C8F2E8C1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMT0</accession>
    <name>A0A670HMT0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Synaptotagmin-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Synaptotagmin XII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SYT12</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Can also form heterodimers. Interacts with SYT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591953.1">
        <property type="nucleotide sequence ID" value="XM_028736120.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591961.1">
        <property type="nucleotide sequence ID" value="XM_028736128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HMT0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001251.1">
        <property type="protein sequence ID" value="ENSPMRP00000001184.1"/>
        <property type="gene ID" value="ENSPMRG00000000874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600233"/>
    <dbReference type="KEGG" id="pmua:114600233"/>
    <dbReference type="CTD" id="91683"/>
    <dbReference type="GeneTree" id="ENSGT00940000158627"/>
    <dbReference type="OMA" id="LQPFGGW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08406">
        <property type="entry name" value="C2B_Synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000080">
        <property type="entry name" value="Putative synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000129">
        <property type="entry name" value="Synaptotagmin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030537">
        <property type="entry name" value="Syt12_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF252">
        <property type="entry name" value="SYNAPTOTAGMIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="151"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="282"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="420" mass="47166" checksum="53B5C9305B7EF92E" modified="2020-06-17" version="1">MDNNVAEHQLSVIRSPPGWEIGIYITGALVLLAIAGVNLWKLWRSGSYPAPSPFPNYDYRYLEQKYGTTYSQIKQKRAASNFRKAGERTSPVRKPSLKMDDTFENINELGTLELMNKDLELAPYGPLKKSISTDSLCSISSIGNNFGHEFTVGQVEVNMEYNVNSNTLHVTLLQGKDLMEKEDVNFESCFVRISLLPDEQIVGISRIQRTAYSVFFDERFSIPLDPSALEENSLRFSIFGIDEDERNISTGVAELKLSDLDLSIRPFNAWLYLQDMNKATDSVGEILLSLSYLPTAERLTVVVVKAKNLVWTNGKMTADPFVKVYLLQDGRKISKKKTATKRDDTNPVFNEAMIFSVPAIVLQELSLRVTVTECCEDGRAENIGHVVIGPAAGGMGITHWNQMLATLRKPVSMWHPLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMZ1</accession>
    <name>A0A670HMZ1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MORN repeat containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MORN2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028580818.1">
        <property type="nucleotide sequence ID" value="XM_028724985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HMZ1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001089.1">
        <property type="protein sequence ID" value="ENSPMRP00000001028.1"/>
        <property type="gene ID" value="ENSPMRG00000000760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594825"/>
    <dbReference type="KEGG" id="pmua:114594825"/>
    <dbReference type="CTD" id="729967"/>
    <dbReference type="GeneTree" id="ENSGT00390000006619"/>
    <dbReference type="OMA" id="MEGDGQF"/>
    <dbReference type="OrthoDB" id="437960at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052849">
        <property type="entry name" value="MORN_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="147" mass="16545" checksum="A2039AF0B5FB5FDE" modified="2020-06-17" version="1">MAKWGLLRRSIVGDRDAEVYKISFVFPNGDKYEGDCTRTIEGVLERSGHGVHTTPDGIIYQGNWKNDKMNGFGRLEHPSGAVYEGEFYNNMFHGTGTYIFTNGAKYTGQFCENKLQGNGEFKDTQGLEWDGTFHYTAAPGLKLKLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNT1</accession>
    <name>A0A670HNT1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HNT1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001614.1">
        <property type="protein sequence ID" value="ENSPMRP00000001514.1"/>
        <property type="gene ID" value="ENSPMRG00000001138.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000031482.1">
        <property type="protein sequence ID" value="ENSPMRP00000029682.1"/>
        <property type="gene ID" value="ENSPMRG00000019196.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="HAMLVIH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004135">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001621">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001307">
        <property type="entry name" value="zinc finger protein 140 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000380">
        <property type="entry name" value="zinc finger protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000588">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF152">
        <property type="entry name" value="SI:DKEY-210J14.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="472" mass="54662" checksum="30AAF4F47057F124" modified="2020-06-17" version="1">MVEVHEMVASQGDVWGVLDEEEPSEVWPERGEEQEKERKLGVQDGANKQEGRETVKPRDEHSVSQEDENQINRVEKKHECTVCGKRFCSRSALARHQSVHSGEKPYECMECGKRFSYSGYLTLHQRTHTGEKPYKCWECGKSFFDSSTLTKHQRTHTGEKPYECMECGKSFSRSSSLNVHQITHTGDKPYECMECGKSFRNSGYLNVHQRTHTGEKPYECMECGKTFSQNFSLTLHQRTHTGEKPYECMECGKSFRSSSYLNVHRRTHTGEKPYKGMECGKSFSCSKSVKMHHIIHTQENHINPYECMECGKSFSARSMLIRHQITHTGEKPYECMECGKRFRNSGHLNVHQITHTGEKPYECMECGKSFRSRSHLNVHQRTHTGEKPYKCWECGKSFFDSSTLTKHQRTHTGEKPYKCMECGKSFNQSASLNVHRRLHTGEKPYKCMECGKSFSDYSTFTKHQRTHRGETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPF2</accession>
    <name>A0A670HPF2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil-helix-coiled-coil-helix domain containing 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HPF2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000977.1">
        <property type="protein sequence ID" value="ENSPMRP00000000922.1"/>
        <property type="gene ID" value="ENSPMRG00000000685.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007683"/>
    <dbReference type="OMA" id="KSWRRIM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033620">
        <property type="entry name" value="Ribosomal_mS37_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278">
        <property type="entry name" value="CHCHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12055" checksum="BC1F7E22F7D03981" modified="2020-06-17" version="1">MAAATPSLGFAASVARLAELKKLWGKQPWMRPYRPLVLANQVSNRRLGLGEATCITEMSLMMASWKQNEFSDVTCAQETQTFFNCAAKAEAEWKSWRRIMRWWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQP9</accession>
    <name>A0A670HQP9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQP9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001484.1">
        <property type="protein sequence ID" value="ENSPMRP00000001397.1"/>
        <property type="gene ID" value="ENSPMRG00000001050.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="IDEYCHG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002502">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001808">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000056">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000355">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000540">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002159">
        <property type="entry name" value="Zinc finger protein 841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="605" mass="69112" checksum="32F1DEA6A1C7B094" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQR7</accession>
    <name>A0A670HQR7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macrophage-expressed gene 1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Perforin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MPEG1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells. Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MPEG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028593897.1">
        <property type="nucleotide sequence ID" value="XM_028738064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HQR7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001505.1">
        <property type="protein sequence ID" value="ENSPMRP00000001417.1"/>
        <property type="gene ID" value="ENSPMRG00000001066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601056"/>
    <dbReference type="KEGG" id="pmua:114601056"/>
    <dbReference type="CTD" id="219972"/>
    <dbReference type="GeneTree" id="ENSGT00390000008048"/>
    <dbReference type="OMA" id="QTHEEGY"/>
    <dbReference type="OrthoDB" id="5950457at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061474">
        <property type="term" value="C:phagolysosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022829">
        <property type="term" value="F:wide pore channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002479">
        <property type="term" value="P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22579">
        <property type="entry name" value="MPEG1_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039707">
        <property type="entry name" value="MPEG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31463">
        <property type="entry name" value="MACROPHAGE-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31463:SF4">
        <property type="entry name" value="MACROPHAGE-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025485476" description="Macrophage-expressed gene 1 protein" evidence="20">
        <location>
            <begin position="21"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="21">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="716" mass="78800" checksum="3A74DBB96753C394" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQS8</accession>
    <name>A0A670HQS8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">COPZ1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQS8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002279.1">
        <property type="protein sequence ID" value="ENSPMRP00000002139.1"/>
        <property type="gene ID" value="ENSPMRG00000001561.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004405"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000008">
        <property type="entry name" value="Coatomer subunit zeta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF2">
        <property type="entry name" value="COATOMER SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="207" mass="23317" checksum="BEE32AA4DBBE1DB2" modified="2020-06-17" version="1">GHPSEAVALPLGRSAVRGSSTWYCLNGPVTLCFSLQEPSLYTVKAILILDNDGDRLFAKYYDDTYPTVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALMENMEGLFLAVDEIVDGGVILESDPQQVLHRVAVRGEDVPLTEQTVSQVLQSAKEQIKWSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRY1</accession>
    <name>A0A670HRY1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HRY1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002104.1">
        <property type="protein sequence ID" value="ENSPMRP00000001980.1"/>
        <property type="gene ID" value="ENSPMRG00000001456.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="OMA" id="TWEEPSH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001630">
        <property type="entry name" value="Zinc finger protein 888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF377">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="345" mass="39717" checksum="099F3C1CD49B5AE5" modified="2020-06-17" version="1">MPPLGDPFPVPALTETFPLFLQELGPFVEVMVNSPEGEQVPLDAWQSPLFKEIKQKGDRDAETIDSRTMSQEEEEVGQQRGSELAEARRMFLGKSAGRLTLRCESFEEACGSKRQQEWLPAVTWEEPSHRSEADGPVPEAALHGVAVKYLCPECGRNFQHKSTLIRHQKMHTGEKPHICLECGKSFRRRDKLIRHQRIHTGQKPHECAECGKSFRERGKLTNHQRIHTGEKPYACPACKKTYRWKEEFVKHLRIHTGERPYGCVLCGKAFISKAHLVSHHRSHTGEKPYECAECRRRFCSKQSLAKHQRVHAEENAYECQDCGKVFRYVSNFAKHQRLHTSDRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HSH5</accession>
    <name>A0A670HSH5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HSH5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002646.1">
        <property type="protein sequence ID" value="ENSPMRP00000002486.1"/>
        <property type="gene ID" value="ENSPMRG00000001639.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286995"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002474">
        <property type="term" value="P:antigen processing and presentation of peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07698">
        <property type="entry name" value="IgC1_MHC_I_alpha3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000204">
        <property type="entry name" value="Major histocompatibility complex, class I-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF242">
        <property type="entry name" value="MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0490">MHC I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="213"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="377" mass="43265" checksum="0443D26E000EB9A2" modified="2020-06-17" version="1">MRGRDIGLLPSSAGPLTLCPLFSSFPGSTSHSLRYFYTAVSEPGQGLPQFIDVGYVDDQQIIQYDSDTKEYLPRVPWMRKAEKEDPQYWHKQTQIAQGNQLAFRVSLQNLQNRYNQSRGIHTYQLMYGCELSSDGRKGGHHQYSYDGRDFIAFDKETLTWTAADTGAQVTKRKWDPDLAWNQGRKAYLEEICIEWLQRYLEYGNETLLRTEAPVVKVTRKADYDGLETLVCQVHGFYPQEIEANWVKDGKVWQEGTLRGLVAPNSDGTYYLLLSVQIDPEERERFRCRVEHDSLEKPLDVAWEKEPAASEPKTHTGRGEGTRAHSLALRTSEILHKQKTWTFCVIAKIGLDRHFKSEKEGVSRKNRTYGNPTQDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTW8</accession>
    <name>A0A670HTW8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecQ-mediated genome instability protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMI2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HTW8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003376.1">
        <property type="protein sequence ID" value="ENSPMRP00000003148.1"/>
        <property type="gene ID" value="ENSPMRG00000002237.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001653"/>
    <dbReference type="OMA" id="RVSLVWM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033045">
        <property type="term" value="P:regulation of sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000224">
        <property type="entry name" value="RecQ mediated genome instability 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032245">
        <property type="entry name" value="RMI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33962:SF1">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33962">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 2 RMI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16100">
        <property type="entry name" value="RMI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="140" mass="15451" checksum="99FEA4E28E56CE82" modified="2020-06-17" version="1">EKWGGASPPPLPPVKVLAAHLRRCRRVPGGPWLLDREEYRRPALAVSLVWLQGTVLAVEEGGSTVRLRDDSGPFVAQGVEKIPKGQPCLSAGKYVMVMGLVMSCSPEPTIRAVKMTDLSGNPLHRDMWQLEVEDLHRHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HVU0</accession>
    <name>A0A670HVU0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HVU0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003913.1">
        <property type="protein sequence ID" value="ENSPMRP00000003651.1"/>
        <property type="gene ID" value="ENSPMRG00000002556.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234669"/>
    <dbReference type="OMA" id="ENMHEYL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="248" mass="28434" checksum="D392A92FC7B3BC42" modified="2020-06-17" version="1">MATRSPTSTSFYDEVTCPICLDYFEDPVTVDCGHNFCQACITQYLGDSDADPCCPLCRERLEANNFNPNWQLASLVLIKKIQEEGQVEGKDGVCKTHGEPLKLFCMDDEVPICEVCNGSNLHRGHSVFPAEEASHQYKERIGVLVKSLKQERKRLVDRKLAKDQKKQKCLKQLETEKQKIVSAFENMHEYLVQKQHLWLDQLEDLTKELERKQDENLTRVSEEISRLNGLIAEMGGKCRQPPSEFLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWN2</accession>
    <name>A0A670HWN2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynein heavy chain coiled coil stalk domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="63"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="4">
        <location>
            <begin position="418"/>
            <end position="533"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004149.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="61075" checksum="8C9198AEDE7D022B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWP1</accession>
    <name>A0A670HWP1_PODMU</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
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                <person name="While G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="11" key="2">
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.</text>
    </comment>
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        <text evidence="1">Belongs to the ohanin/vespryn family.</text>
    </comment>
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    </dbReference>
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        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0528">Neurotoxin</keyword>
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        <location>
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    </feature>
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40830" checksum="2B2B1377CB5D6A92" modified="2020-06-17" version="1">MDQSTPGTPEQETTCSICREYLTDPVTLDCGHNFCRGCITTYCKILEYQDGGATDSSCPQCRETVQQRNFRPNCQLANLVELVKKLQEGRKEDGKRGMCPRHQEPLKLFCNNDQDPICVVCDRSKEHREHSVFPMEEASQEYKVEKHHHQQTLFSKNERVVNLSLSLSQESRTTELRKREKIIRMMLNVTLYPDTAHPNLILSEDLKCVQWGDRRQDLPDNSERFDKEMFVLGRKRFTSGRHWWEVEVGGEWAEWAVSVARESVRRKGDITLNPSEGFWALQKTMVDTFGSFSDWQLSASTSPKLTVVYARSELRKIRVSLHYEEGLVEFFDGDTNNSIFAFPSVRPMGRCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWZ0</accession>
    <name>A0A670HWZ0_PODMU</name>
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        <recommendedName>
            <fullName evidence="3 6">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ORC2</name>
    </gene>
    <organism evidence="10 11">
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028606950.1">
        <property type="nucleotide sequence ID" value="XM_028751117.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028606956.1">
        <property type="nucleotide sequence ID" value="XM_028751123.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028606963.1">
        <property type="nucleotide sequence ID" value="XM_028751130.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028606969.1">
        <property type="nucleotide sequence ID" value="XM_028751136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HWZ0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004476.1">
        <property type="protein sequence ID" value="ENSPMRP00000004193.1"/>
        <property type="gene ID" value="ENSPMRG00000002871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607689"/>
    <dbReference type="KEGG" id="pmua:114607689"/>
    <dbReference type="CTD" id="4999"/>
    <dbReference type="GeneTree" id="ENSGT00390000015228"/>
    <dbReference type="OMA" id="AHERYFF"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="8">
        <location>
            <begin position="280"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="9">
        <location>
            <begin position="497"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="569" mass="64340" checksum="3BAC84537EC011B2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HX26</accession>
    <name>A0A670HX26_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HX26"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004514.1">
        <property type="protein sequence ID" value="ENSPMRP00000004228.1"/>
        <property type="gene ID" value="ENSPMRG00000002894.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164389"/>
    <dbReference type="OMA" id="HHYHANI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF165">
        <property type="entry name" value="ALPHA-1-ANTITRYPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025402977" description="Serpin domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="7">
        <location>
            <begin position="45"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="195" mass="21734" checksum="50E5BB20AA1EE6D3" modified="2020-06-17" version="1">GEKGTSGRNTMPHFNLYLIFAGLLAVANCQTSQPGNLPYEKIAPGNTEFAFIIYCQVAPEAHKKNILFSPTIISMPLALLVLAAKSTTRSQLLSGLCFNRTNISDTEAEIQRSIGNTLFPNKKFKLRKKFLNNAKYFYQADVLPTNFENATEAENQINNYIKEKTHGKITDIVKDLDTRAILGVVTNLKCPLLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXG4</accession>
    <name>A0A670HXG4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Phospholipase A2</fullName>
            <ecNumber evidence="4 13">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114594260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The N-terminal C2 domain associates with lipid membranes upon calcium binding.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="4 13"/>
    <dbReference type="RefSeq" id="XP_028579530.1">
        <property type="nucleotide sequence ID" value="XM_028723697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HXG4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004081.1">
        <property type="protein sequence ID" value="ENSPMRP00000003817.1"/>
        <property type="gene ID" value="ENSPMRG00000002640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114594260"/>
    <dbReference type="KEGG" id="pmua:114594260"/>
    <dbReference type="GeneTree" id="ENSGT01030000234606"/>
    <dbReference type="OMA" id="IYLCLNV"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FabD/lysophospholipase-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9 12 13" id="KW-0442">Lipid degradation</keyword>
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        <location>
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        <location>
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        </source>
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        </source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="816" mass="94703" checksum="B8CCB1C1C15260E8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HY46</accession>
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        <submittedName>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="48" mass="5345" checksum="60E49A7A34FD7D98" modified="2020-06-17" version="1">MVITSGNEEEKGNQEKESKEESILAMLGIIGTILNLVVIIFVYIYTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZ16</accession>
    <name>A0A670HZ16_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="29">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">PI4K2A</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 29">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Golgi apparatus</location>
            <location evidence="28">trans-Golgi network membrane</location>
            <topology evidence="28">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Membrane</location>
            <topology evidence="29">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Presynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Synapse</location>
            <location evidence="26">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 29">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="29"/>
    <dbReference type="RefSeq" id="XP_028586393.1">
        <property type="nucleotide sequence ID" value="XM_028730560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HZ16"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004682.1">
        <property type="protein sequence ID" value="ENSPMRP00000004387.1"/>
        <property type="gene ID" value="ENSPMRG00000002999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597587"/>
    <dbReference type="CTD" id="55361"/>
    <dbReference type="GeneTree" id="ENSGT00390000010434"/>
    <dbReference type="OMA" id="IKCDCPL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035651">
        <property type="term" value="F:AP-3 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Lsb6/PI4K2"/>
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        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2-ALPHA"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="16 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="25" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 29" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="24" id="KW-0449">Lipoprotein</keyword>
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    <keyword evidence="20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0564">Palmitate</keyword>
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    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0770">Synapse</keyword>
    <keyword evidence="11" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="12 29" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="127"/>
            <end position="456"/>
        </location>
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            <begin position="1"/>
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            <begin position="13"/>
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    <sequence length="482" mass="53744" checksum="A2116A232A5EF94F" modified="2020-06-17" version="1">MDETSPLVSPERGPAAGYGVPGGAVRSPPCPAAPSAPSAPPPCPSPPGSPAGGRDRERQPLLDRGAGAERGARGAVGSAGAAQVQAPVGLGAAAAAARGEREPRNEFPDDPEFAEVVRQSELASERGIYPERIYQGSSGSYFVKDPQGKIIGVFKPKNEEPYGQLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFHRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDCPLDSTSVRDSEWVVVKEPIIKLAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFIKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDGKSPLHLVQMPPVIVETARSHQRSASESYTQSFQSRKPFFSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I0Y8</accession>
    <name>A0A670I0Y8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BCL6 corepressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BCOR</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the BCOR family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000005876.1">
        <property type="protein sequence ID" value="ENSPMRP00000005521.1"/>
        <property type="gene ID" value="ENSPMRG00000003763.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153737"/>
    <dbReference type="OMA" id="CTEEKHP"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140261">
        <property type="term" value="C:BCOR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:transcription corepressor activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of bone mineralization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of tooth mineralization"/>
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    </dbReference>
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        <property type="term" value="P:odontogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0065001">
        <property type="term" value="P:specification of axis polarity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="BCOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047144">
        <property type="entry name" value="BCOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032365">
        <property type="entry name" value="PUFD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038227">
        <property type="entry name" value="PUFD_som_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24117">
        <property type="entry name" value="AGAP007537-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24117:SF8">
        <property type="entry name" value="BCL-6 COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BCL-6 corepressor non-ankyrin-repeat" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1404"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1437"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="BCL-6 corepressor PCGF1 binding" evidence="11">
        <location>
            <begin position="1540"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="764"/>
            <end position="829"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1088"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1296"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587254.1">
        <property type="nucleotide sequence ID" value="XM_028731421.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028587255.1">
        <property type="nucleotide sequence ID" value="XM_028731422.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000006518.1">
        <property type="protein sequence ID" value="ENSPMRP00000006129.1"/>
        <property type="gene ID" value="ENSPMRG00000004137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597931"/>
    <dbReference type="KEGG" id="pmua:114597931"/>
    <dbReference type="CTD" id="10051"/>
    <dbReference type="GeneTree" id="ENSGT00900000141094"/>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905821">
        <property type="term" value="P:positive regulation of chromosome condensation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051984">
        <property type="term" value="P:positive regulation of chromosome segregation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905820">
        <property type="term" value="P:positive regulation of chromosome separation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="16">
        <location>
            <begin position="610"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="531"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="766"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="874"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1293" mass="147452" checksum="C5B29BB63460411C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4Y7</accession>
    <name>A0A670I4Y7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane channel-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMC8</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I4Y7"/>
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        <property type="gene ID" value="ENSPMRG00000004500.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244894"/>
    <dbReference type="OMA" id="KKYTLMR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043120">
        <property type="term" value="F:tumor necrosis factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902041">
        <property type="term" value="P:regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010803">
        <property type="term" value="P:regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF39">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="231"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU310713"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="639" mass="73507" checksum="171B9C9F31FE111A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I634</accession>
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        </alternativeName>
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        <name evidence="9" type="primary">MPV17</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
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    </reference>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="2 8">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:channel activity"/>
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        <property type="project" value="Ensembl"/>
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            <end position="155"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363053"/>
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    </evidence>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
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</entry>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
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                <person name="Marsik P."/>
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                <person name="Salvi D."/>
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                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I6C0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007758.1">
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        <property type="gene ID" value="ENSPMRG00000004906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600902"/>
    <dbReference type="KEGG" id="pmua:114600902"/>
    <dbReference type="CTD" id="100113407"/>
    <dbReference type="GeneTree" id="ENSGT00940000160424"/>
    <dbReference type="OMA" id="DHMINLS"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10190">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="120"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
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        <location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="192" mass="20491" checksum="D548A46C1FAC349E" modified="2020-06-17" version="1">MSPPPRGAHPIRAPSARSVPSGARPRLLRDWWRSQPRLAGRRPSDDGAGQAAASSTSAAGMKAEAGDSSMINLSVQQVLSLWAHGTSLRHLTEMWYWVFLWALFSSLFVHGAAGVLMFVMLQRHRQGRVISIIAVSIGFLGSVTGAMITSAAVAGIFRVAGKSMAPLQALVFGIGQTVLTLIISFSRILATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8J6</accession>
    <name>A0A670I8J6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I8J6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008569.1">
        <property type="protein sequence ID" value="ENSPMRP00000008014.1"/>
        <property type="gene ID" value="ENSPMRG00000005425.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183173"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="2">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="267" mass="29008" checksum="31A5AD45C43D05F0" modified="2020-06-17" version="1">MEDPLPAGAPLSAPSEVASGSGNPPAFPELQRLRVREASHQRIGATLCLRADKSQPAPLPTMADQAAVLVALAQENQVLTHTIQQLSNAAIALQQCLEALPASGADTPASDKYPVALPEKFNGSQASFPMFLAQTKLYIQGRSRNFPDDRTKVHFLNSLLKDRAAKWALPLLRQNSPLLTDYTGFCNHLEILFGNPQKGSQANRAIRRLKQDKSIVAAYATECRQHSWLPAPVLPSSSTTTAKSLEEPMQLGAVRPCLSPSEKTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IG51</accession>
    <name>A0A670IG51_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DARS1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670IG51"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011030.1">
        <property type="protein sequence ID" value="ENSPMRP00000010357.1"/>
        <property type="gene ID" value="ENSPMRG00000006884.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234618"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000144">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="18">
        <location>
            <begin position="198"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="503" mass="57154" checksum="7A35C1CCDC125A80" modified="2020-06-17" version="1">MPGVAARKNQERNRDSAMEQPPADDYAKERYGVLPLIQSQEKPDRVLVRIKDLTAEKADDVVWVRGRIHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDIEGVVRKVPHKIGGCTQQDIELHVQRIYVISLAEPRLPLQLDDAIRPEVEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICQLFRETLIHKGFVEIQTPKIISAASEGGANVFTVSYFKSSAYLAQSPQLYKQMCICADFDKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVDEIADTMVQIFKGLQERFQTEIQTVSKQFPCEPFKFLEPTLRLEYREALAMLREAGVEMGDEDDLSTPSEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPANPKTSNSYDMFMRGEEILSGAQRVHDPQLLTERALHHGIDLEKIKSYIDSFRFGAPPHAGGGIGLERVTMLFLGLSNVRQTSMFPRDPKRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IH92</accession>
    <name>A0A670IH92_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Whey acidic protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114599870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the venom Kunitz-type family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IH92"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011426.1">
        <property type="protein sequence ID" value="ENSPMRP00000010712.1"/>
        <property type="gene ID" value="ENSPMRG00000007116.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165527"/>
    <dbReference type="OMA" id="ACEQGCA"/>
    <dbReference type="OrthoDB" id="8935200at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044483">
        <property type="term" value="P:venom-mediated perturbation of hemostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000021">
        <property type="entry name" value="Serine protease inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051388">
        <property type="entry name" value="Serpin_venom_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46751">
        <property type="entry name" value="EPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46751:SF1">
        <property type="entry name" value="WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025480562" evidence="6">
        <location>
            <begin position="25"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="8">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="8">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="8">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="180"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="7">
        <location>
            <begin position="238"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="298" mass="32698" checksum="E9C1B571CE70722C" modified="2020-06-17" version="1">MKSGALVILVGLLALWAELTPASAQRLPGKPGTCPTLIQNNDTQCGQFCSWDNSCPGSERCCQTGCGQQCMLPREVYPGYCPRLSPQPGQATNCSATCNNDQDCGSVYLPRKKCCSNGCGKTCQAAEEEHPGVCPKRELVNTFVPCNDTCRDDRDCPLTQKCCFTMCSRGCLDSVRSDRCQLPPKTGRCLAAFPRYYYNPSEKKCVLFTYGGCEGNSNNFETKEACEAACGKISPEVCKLPKDPGPCLGYSQFYYYNSATRKCEIFVYGLCGGNGNRFRTKLECMMVCGQRENSTEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHY2</accession>
    <name>A0A670IHY2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CLDN11</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with tetraspanin-3/TSPAN3. Interacts with OCLN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell junction</location>
            <location evidence="11">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028587394.1">
        <property type="nucleotide sequence ID" value="XM_028731561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IHY2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012308.1">
        <property type="protein sequence ID" value="ENSPMRP00000011523.1"/>
        <property type="gene ID" value="ENSPMRG00000007719.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597974"/>
    <dbReference type="KEGG" id="pmua:114597974"/>
    <dbReference type="CTD" id="5010"/>
    <dbReference type="GeneTree" id="ENSGT00890000139496"/>
    <dbReference type="OMA" id="CIRMGNE"/>
    <dbReference type="OrthoDB" id="9411914at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045178">
        <property type="term" value="C:basal part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005883">
        <property type="term" value="C:neurofilament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008366">
        <property type="term" value="P:axon ensheathment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120192">
        <property type="term" value="P:tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003555">
        <property type="entry name" value="Claudin11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01384">
        <property type="entry name" value="CLAUDIN11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0796">Tight junction</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="207" mass="22134" checksum="B5B2CC0D399FB656" modified="2020-06-17" version="1">MVATCLHLTGFVASFVGWISLIVATSTNDWVVTCGYTITTCRKMDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAVFLLVTVLPCIRMGNEPGVAKYRRSQLGGILLILLALCGVVATIWFPVSAHRETMIMSFGYSLYTGWIGSALCLFGGCIIVCCSGDAETFGQNRFYYGSGSSSPTHAKSAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIN9</accession>
    <name>A0A670IIN9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="6">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">EIF6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <text evidence="6">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028590586.1">
        <property type="nucleotide sequence ID" value="XM_028734753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IIN9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012647.1">
        <property type="protein sequence ID" value="ENSPMRP00000011843.1"/>
        <property type="gene ID" value="ENSPMRG00000007915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599464"/>
    <dbReference type="KEGG" id="pmua:114599464"/>
    <dbReference type="CTD" id="3692"/>
    <dbReference type="GeneTree" id="ENSGT00390000015972"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:lamin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035278">
        <property type="term" value="P:miRNA-mediated gene silencing by inhibition of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042304">
        <property type="term" value="P:regulation of fatty acid biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of glycolytic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of megakaryocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="245" mass="26539" checksum="8C7066D1A0BC0089" modified="2020-06-17" version="1">MAVRASFENNNEIGCFAKLTNAYCLVAIGGSEGFYSVFEGELSDTIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVRIQRVEERLSALGNVTTCNDYVALVHPDIDRETEEILADVLKVEVFRQTVAEQVLVGSYCAFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVIESVFKLNESQPSTIATTMRDSLIDSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IIY1</accession>
    <name>A0A670IIY1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LIM domain 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LMO7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSPMRT00000012770.1">
        <property type="protein sequence ID" value="ENSPMRP00000011958.1"/>
        <property type="gene ID" value="ENSPMRG00000007819.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183159"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21277">
        <property type="entry name" value="CH_LMO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000041">
        <property type="entry name" value="LIM and calponin homology domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000038">
        <property type="entry name" value="LIM and calponin homology domains-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031865">
        <property type="entry name" value="DUF4757"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029978">
        <property type="entry name" value="LMO-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46767">
        <property type="entry name" value="LIM DOMAIN ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46767:SF1">
        <property type="entry name" value="LIM DOMAIN ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15949">
        <property type="entry name" value="DUF4757"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="1488"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="684"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="895"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1314"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1435"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="895"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="913"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="947"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1178"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1322"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1353"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1402"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1435"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1458"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1560" mass="176485" checksum="4E327C5EBD647F4D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IN78</accession>
    <name>A0A670IN78_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NK2 homeobox 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NKX2-8</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IN78"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014311.1">
        <property type="protein sequence ID" value="ENSPMRP00000013405.1"/>
        <property type="gene ID" value="ENSPMRG00000008965.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161610"/>
    <dbReference type="OMA" id="WNSPPQE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050680">
        <property type="term" value="P:negative regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000101">
        <property type="entry name" value="NK2 homeobox 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF117">
        <property type="entry name" value="NK2 HOMEOBOX 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="208" mass="22630" checksum="0B25921A8CBFD7BB" modified="2020-06-17" version="1">ISGKRKCFFTQRTVKLWNSPPQEAVTAPNLDASDESGPESRSRPAAASTRADEDDDEKKKKRRVLFSKAQTLALERRFRQQRYLSAPEREQLAHLLRLTPTQVKIWFQNHRYKMKRAKGSGAGGERAGEGAGAGGAAAAPLLRRVVVPVLVREGKACQSCSGAAQDYGGAQSALGLQGYPAFPQAASLSLFPAYQHLAPPALVSWNWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INK8</accession>
    <name>A0A670INK8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670INK8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014669.1">
        <property type="protein sequence ID" value="ENSPMRP00000013728.1"/>
        <property type="gene ID" value="ENSPMRG00000009206.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000210870"/>
    <dbReference type="OMA" id="IDQPFKC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="319"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="452" mass="49745" checksum="B7E773719996506E" modified="2020-06-17" version="1">MEEKEFTLDPYLLALSGNNIQQYCTMLSWLELKNPKPEIYFEMEQGLTLPLSLAHIVEEFEILPCLSQDNRTLQTSEPESPQQESAAVPLVRLQYNFVPKLEGGVLQGKPSPVSEIQHRTGLQARSDEPISSGKNPGKPPEVPRDHSNGEGRVGRLQQEGSRQPTAMCFAAATVSQGSERSDVRDVAGPNLLLRKGGHRCDSTAEEPTIHQRKGTSCLSGNAREFIDKPLSFQIREGACPREGSFLGPREGGKPTLKLNPPAPPEQTHKGLNGRPPVSFCAASLSAHQKTFTGERQKLFSPLGLQGLPSPAGDMVEKPFKCPDCGKGFLHRSSIPRHQNLGCLGSLPHQKSPCGEKPLRGPGGGMSLVERKQCSACKQRSVPAPGVQKNRAAGEKPFRCPDCSNTFTEKFSMIRHQALHQSEKPFKCPCCDKSYTRRCHLKRHQQMKHKTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IPH6</accession>
    <name>A0A670IPH6_PODMU</name>
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            <fullName evidence="15">Secretory phospholipase A2 receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">180 kDa secretory phospholipase A2 receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">M-type receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PLA2R1</name>
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    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="18">Interacts with sPLA2-IB/PLA2G1B; this interaction mediates intracellular signaling as well as clearance of extracellular sPLA2-IB/PLA2G1B via endocytotic pathway. Interacts with sPLA2-X/PLA2G10; this interaction mediates sPLA2-X/PLA2G10 clearance and inactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000014856.1">
        <property type="protein sequence ID" value="ENSPMRP00000013900.1"/>
        <property type="gene ID" value="ENSPMRG00000009011.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244842"/>
    <dbReference type="OMA" id="GGDICEH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phospholipase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090403">
        <property type="term" value="P:oxidative stress-induced premature senescence"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of arachidonate secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cytokine production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of DNA damage response, signal transduction by p53 class mediator"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of podocyte apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:reactive oxygen species metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090399">
        <property type="term" value="P:replicative senescence"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
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        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Secretory phospholipase A2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000032">
        <property type="entry name" value="Secretory phospholipase A2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Secretory phospholipase A2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000042">
        <property type="entry name" value="secretory phospholipase A2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24562">
        <property type="entry name" value="CysR_MRC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
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        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type-II" evidence="21">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="211"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
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            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
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            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="647"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="789"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="936"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="1092"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="1228"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046689"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1397" mass="160436" checksum="924BF2AD8A877884" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IR72</accession>
    <name>A0A670IR72_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IR72"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014638.1">
        <property type="protein sequence ID" value="ENSPMRP00000013702.1"/>
        <property type="gene ID" value="ENSPMRG00000009191.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286934"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000056">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000180">
        <property type="entry name" value="Zinc finger protein 689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="322" mass="35368" checksum="162933DA1416FD3F" modified="2020-06-17" version="1">MEDGTLKTDLAVEELKQRLSNFSRKRAILQEALLRFKETLCVEVDGDIGYRTTPSLQSVPIHPPQENRSKTSAADVIQELTACKRTAVHSEELPVDSPLTTAAIARTIKEEEEEAGIPAAGVTLSGGIKEENPQQNGHEPVELPATRPPRSECSAPKSRERVGAGQAAFATGRRQGTNPATGAGQPAWPKGGLAKAAAQKRKEKCFPCPECGKTFRQFGVLITHHRLHTGEKPYSCTYCAKRFSDYSNLIAHQRTHTGEKPYRCADCGKSFTRSTTLTIHQRGHTREKPYPCPQCGKRFSRSSNLTIHQRTHAGAMGKNSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRA1</accession>
    <name>A0A670IRA1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytohesin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CYTH4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028603468.1">
        <property type="nucleotide sequence ID" value="XM_028747635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IRA1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015528.1">
        <property type="protein sequence ID" value="ENSPMRP00000014535.1"/>
        <property type="gene ID" value="ENSPMRG00000009694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605926"/>
    <dbReference type="CTD" id="27128"/>
    <dbReference type="GeneTree" id="ENSGT00940000160865"/>
    <dbReference type="OMA" id="LYNPNCK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01252">
        <property type="entry name" value="PH_GRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000003">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000009">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF323">
        <property type="entry name" value="CYTOHESIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="9">
        <location>
            <begin position="54"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="259"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="394" mass="45551" checksum="6F8ED81EBBF76C35" modified="2020-06-17" version="1">MDARPTSTSDLNETEEAELQTIKKHKEELLADIQRLKDEIAEVFEEIDRFQQTQTSKLAQRDKEMCVGRKKFNMDPTKGIQYLIEHKILSSNVEEIAKFLYKGEGLNKTAIGDYLGERDPLNLQILQAFVECHQFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFANRYCQCNPGVFQSTDTCYILSFSVIMLNTSLHNPNVKDKPPFERFVSMNRGINDGGDLQEPLLWSLFDSIKNEPFSIPEDDGNDLTHTFFNPSQEGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPLGIIPLENLSVRKVEDQKKRNCFELFNTNSKGQKIKACKMDGDGKVVEGKHQSYKISAPSAEERDLWIDAIRTSITQDPFYDLVAARKKKIASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IRV4</accession>
    <name>A0A670IRV4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAST kinase domains 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FASTKD5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
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        <text evidence="1 12">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
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        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with TMEM35A/NACHO.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptotagmin family.</text>
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    <dbReference type="RefSeq" id="XP_028558003.1">
        <property type="nucleotide sequence ID" value="XM_028702170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J051"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019027.1">
        <property type="protein sequence ID" value="ENSPMRP00000017878.1"/>
        <property type="gene ID" value="ENSPMRG00000011801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581712"/>
    <dbReference type="KEGG" id="pmua:114581712"/>
    <dbReference type="CTD" id="84258"/>
    <dbReference type="GeneTree" id="ENSGT00940000161770"/>
    <dbReference type="OMA" id="SHNERCD"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903861">
        <property type="term" value="P:positive regulation of dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08385">
        <property type="entry name" value="C2A_Synaptotagmin-1-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08403">
        <property type="entry name" value="C2B_Synaptotagmin-3-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000005">
        <property type="entry name" value="Synaptotagmin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000011">
        <property type="entry name" value="Synaptotagmin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF176">
        <property type="entry name" value="SYNAPTOTAGMIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="229"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="361"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="193"/>
        </location>
    </feature>
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        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004160"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="526" mass="59256" checksum="AC41FC467ECCC53D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J171</accession>
    <name>A0A670J171_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger CCHC-type containing 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ZCCHC10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028573787.1">
        <property type="nucleotide sequence ID" value="XM_028717954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J171"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018450.1">
        <property type="protein sequence ID" value="ENSPMRP00000017329.1"/>
        <property type="gene ID" value="ENSPMRG00000011467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591235"/>
    <dbReference type="KEGG" id="pmua:114591235"/>
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    <dbReference type="GeneTree" id="ENSGT00730000111200"/>
    <dbReference type="OMA" id="SRTMQFK"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-CCHC_3"/>
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    </dbReference>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="175" mass="18958" checksum="9BEA8271653C0E4F" modified="2020-06-17" version="1">MATPMHRLIARRQAEANKQHVRCQKCLEFGHWTYECTGKRKYLHRPSRTTEFKKALQEKEKQLLQQSSGECTTDRKSKKKRSKSVTSSSSSSSASSASESSSESEDSSSSSSDDSDSDESTSSSSSSPSSSSSSSSSDFETDSSSSSSSSSSSTDSSTDDEPPKKKKKKSNLVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1M2</accession>
    <name>A0A670J1M2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J1M2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018384.1">
        <property type="protein sequence ID" value="ENSPMRP00000017267.1"/>
        <property type="gene ID" value="ENSPMRG00000011433.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006553"/>
    <dbReference type="OMA" id="SLRYTEI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
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        <location>
            <begin position="57"/>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="97" mass="11028" checksum="5A99A7FB2B07E0CE" modified="2020-06-17" version="1">ISPFHCLTFLNVLFFRTQPPPRLPVGPSHKFANNYYCTRDGRRETFPPIVLVSAQKRLAPGQQHASSESSIAPMERKPVKPGPAPRKWELSKDEPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2J2</accession>
    <name>A0A670J2J2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EPC1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
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        <property type="component" value="Chromosome 12"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="813" mass="90914" checksum="D3F327067B18092D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3G0</accession>
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        <submittedName>
            <fullName evidence="4">Lecithin retinol acyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LRAT</name>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
                <person name="Andersson L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylcholine-retinol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032370">
        <property type="term" value="P:positive regulation of lipid transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006776">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRAT"/>
    </dbReference>
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        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
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        <property type="entry name" value="LECITHIN RETINOL ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LECITHIN RETINOL ACYLTRANSFERASE"/>
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        <property type="entry name" value="LRAT"/>
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    </dbReference>
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        <property type="entry name" value="LRAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="3">
        <location>
            <begin position="70"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR642288-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="250" mass="28407" checksum="43966818F8C12AFF" modified="2020-06-17" version="1">MNQEQLQPQNKNKISTMKNPMYEIASLLLEKFLLLANFKLLGVGSGAEEEEKKKKRCCYYDTTYFKPGDLLEVPRTLFIHFGIYLGDNRVAHLMPDILPALTNDQKQIQKVVTNKRLIFGVITKMARIRVDTVEDFAYGGSILVNHMDKLFKNNVLRDEEVVCRAEKLVGATEYSLLWNNCEHFVTFCRYGSAVSFQTEKFCETVKMIIRDQRSVLASALLGLVSILCLGLAPSTTLPTIIIPFILWMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4S3</accession>
    <name>A0A670J4S3_PODMU</name>
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        <submittedName>
            <fullName evidence="18">Zinc finger and BTB domain containing 40</fullName>
        </submittedName>
    </protein>
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        <name evidence="18" type="primary">ZBTB40</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J4S3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020466.1">
        <property type="protein sequence ID" value="ENSPMRP00000019276.1"/>
        <property type="gene ID" value="ENSPMRG00000012578.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151052"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18225">
        <property type="entry name" value="BTB_POZ_ZBTB40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000645">
        <property type="entry name" value="Zinc finger and BTB domain containing 40"/>
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    </dbReference>
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        <property type="entry name" value="Zinc finger and BTB domain containing 40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger and BTB domain containing 40"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001792">
        <property type="entry name" value="Zinc finger and BTB domain-containing 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002248">
        <property type="entry name" value="Zinc finger and BTB domain-containing 40"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002349">
        <property type="entry name" value="Zinc finger and BTB domain-containing 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003097">
        <property type="entry name" value="Zinc finger and BTB domain-containing 40"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000909">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 40"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001061">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030404">
        <property type="entry name" value="ZBTB40_BTB_POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF0">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="16">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="618"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="647"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="772"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="801"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="915" mass="100831" checksum="894C844F415F9024" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J546</accession>
    <name>A0A670J546_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Striatin interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">STRIP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STRIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J546"/>
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        <property type="protein sequence ID" value="ENSPMRP00000018392.1"/>
        <property type="gene ID" value="ENSPMRG00000012099.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00400000022095"/>
    <dbReference type="OMA" id="KMTRAMR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022604">
        <property type="term" value="P:regulation of cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
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        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF7">
        <property type="entry name" value="STRIATIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="390"/>
        </location>
    </feature>
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        <location>
            <begin position="487"/>
            <end position="844"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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        </location>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00007062"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046123"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018392.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="864" mass="99030" checksum="0DAFA63C8E2C1E2D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J692</accession>
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        <submittedName>
            <fullName evidence="1">RAD9 checkpoint clamp component B</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="primary">RAD9B</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Laterata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="C:checkpoint clamp complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="349" mass="38959" checksum="1CA452890D68ED3B" modified="2025-10-08" version="2">MHCILKCENTNASFKISSTVFGRAIHAIARISDEFWFDPTEKGLSLRSVNSSQSAYACVFFSSIFFHHYSCRNTPELGLNKNHTHLAYKLVIKAVLPIFRCLNTVERNIEKCNIYTNFNDCHVVFQLFCKHGVVKTHNLAFQECEPLQAVFAKHLCPNAMKIQSRQLSDILIHFPTCQNEVTVAVTPVKVCFKTYTDEEMDFAKAMHTEIHINPEEFEYFQVGVDTEVTFCLKELRGLLTFAEAITAPVSIHLDVSGKPVVFSIEDMLIEASFVLATLADTEGRTPSHESPLLLQCQKRIRVGVEEEFLLCCGPEENPSSKAGSCIVVGGEFPLGTNGVSSSPAITSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J741</accession>
    <name>A0A670J741_PODMU</name>
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        <submittedName>
            <fullName evidence="4">Endonuclease domain-containing 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114605273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028602142.1">
        <property type="nucleotide sequence ID" value="XM_028746309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J741"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021547.1">
        <property type="protein sequence ID" value="ENSPMRP00000020293.1"/>
        <property type="gene ID" value="ENSPMRG00000013212.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605273"/>
    <dbReference type="GeneTree" id="ENSGT01030000234592"/>
    <dbReference type="OMA" id="RNNEMRV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039015">
        <property type="entry name" value="ENDOD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472:SF26">
        <property type="entry name" value="ENDONUCLEASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472">
        <property type="entry name" value="ENDONUCLEASE DOMAIN-CONTAINING 1 PROTEIN ENDOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="2">
        <location>
            <begin position="136"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="347" mass="38868" checksum="5E4B8F349F1D0DF2" modified="2020-06-17" version="1">MCQKKQRCEEASCYRERWGGGFPPFLGIFCVGFVSGGSLVTAALAKRTRSRCLDSSSHQPQPGRQVSDGTYRTVKNSLAMLLPFLLYGAAHFLAAAKGEVVQDFKNCLEFFLDKMPPGESLTPPREAKICQFYRNAYRFATMYDREKRIPIYSAYKCKPGKGHRYQGWMIEPQLVDPTLGKGMEDERETNIAATGIKKSQATFDDYAQALSIEKGHLNPVSHQPDEDSRAATSTLTNIVPQYSKLNEGAWAEHESLLKKEAQACHDMYVLVGAVPGDEYISDLRVNKPSHIWSAACCVLDNQHRKSWAALAKNSENEVKEYSLETLQKILAELYGKKKVDLFNGSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J839</accession>
    <name>A0A670J839_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biliverdin reductase B</fullName>
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        <name evidence="3" type="primary">BLVRB</name>
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    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028741793.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000021908.1">
        <property type="protein sequence ID" value="ENSPMRP00000020628.1"/>
        <property type="gene ID" value="ENSPMRG00000013403.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00390000014810"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025392770" evidence="1">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="210" mass="22794" checksum="41D2AAADF538F156" modified="2020-06-17" version="1">MAAACKRIAIFGATGMTGLATLAQAVEAGYQVTVLVRDPVRLPPEPHPAQVVVGDVLNPADVDRAVKGQDAVIVILGTRNDLSPTTMMSEGTRNIVAAMKSHGIRKVVVCLSAFLMWDLDKVPAKLRPVTEDHIRMQQILKESGLDCVYVMPPHIAGDQPLTGDYTVTVDTSSGSRVISKHDLGHFFLKCLATSEYDGKNVYLSRHYPKE</sequence>
</entry>
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    <accession>A0A670J8B1</accession>
    <name>A0A670J8B1_PODMU</name>
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        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pereira P."/>
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                <person name="Bosakova Z."/>
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                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J8B1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021986.1">
        <property type="protein sequence ID" value="ENSPMRP00000020703.1"/>
        <property type="gene ID" value="ENSPMRG00000013449.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278308"/>
    <dbReference type="OMA" id="LMSCERY"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:urotensin II receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF53">
        <property type="entry name" value="UROTENSIN-2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
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    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
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    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="133"/>
            <end position="151"/>
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    </feature>
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            <end position="202"/>
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            <end position="287"/>
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        <location>
            <begin position="43"/>
            <end position="284"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="351" mass="38814" checksum="492B1A185D7A7F92" modified="2020-06-17" version="1">MDPPTTNLSLWVPLGNGTVSEGGESAAALGAVLSLMCATGVAGNLYALAVVRASPSASSLRVHLVNLALADLLYLSTAPFIVHNGLVKDCLDLLTMHASIFLLTLMSCERYAAVAHPFQAARRARRCRRPLALAIWLLSFALALPMMVMIHQEERAVGDGVPVRRLCSPTWSEEQYRAYLSVLFSTSIVAPGIIIGSLYWRLARTYWVSQTRGGLGRSPKNRVFLLILVIVLAFWACYLPFWIWQLLPLYCQQAARLPVHTEISINHLVTCLTYGNSCINPFLYTLLTRNYREYLRARQRGSSRTSLIFIPFAPAWCSGWSVGLGPGRQTRVQIPTRPTSQGCCVDKMGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8G4</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J8G4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022037.1">
        <property type="protein sequence ID" value="ENSPMRP00000020753.1"/>
        <property type="gene ID" value="ENSPMRG00000013475.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000250670"/>
    <dbReference type="OMA" id="AIHPVAK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="302" mass="33239" checksum="D9FE7D9B4A57FAD5" modified="2020-06-17" version="1">VPDHPVFLFPAQPPVPDYPVLLFPARPPVPDYPVLLFPARPPVPDHPVLLFPARPPVPDYPVLLFPARPPVPDYPVFLFPAQPPVPDYPVLLFPARPPVPDHPVFLFPAQPPVPDYPVLLFPARPPVPDYPVLLFPARPPVPDYPVLLFPAQPPVPDYPVLLFPARPPVPNHPVLLFPARPPVPDYPVLLFPARPPVPDYPVLLFPARPPVPDYPVLLFPARPPVPDYPVLLFPAQPPVPDYPVLLFPARPPVPNHPVLLFPARPPVPDYPAGSFTPDPAFTTFLLSVAGRNTTCSAARPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JDG1</accession>
    <name>A0A670JDG1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670JDG1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023797.1">
        <property type="protein sequence ID" value="ENSPMRP00000022401.1"/>
        <property type="gene ID" value="ENSPMRG00000014544.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161402"/>
    <dbReference type="OMA" id="AREYACP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="189" mass="21848" checksum="0EE12BF1DDA3444A" modified="2020-06-17" version="1">MSEIIKCLQSCLYGLFPFSFASPLAEDAYKTQVRIDDEPAYLDILDTAGQAEFTAMRDQYMRGGEGFVICYSITDRQSFQEAAEFKELIYRVRHTYDIPVVLVGNKIDLKEFRQVSREEGVNLARQYACPFFETSAALHFYIDDVFHKLVREIRKREKSLPPADGKLKNKDSLWQKLKGSLKKKKEIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JDZ6</accession>
    <name>A0A670JDZ6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JDZ6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024022.1">
        <property type="protein sequence ID" value="ENSPMRP00000022606.1"/>
        <property type="gene ID" value="ENSPMRG00000014683.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287023"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="377" mass="42962" checksum="0D00897A6265A4B4" modified="2020-06-17" version="1">MTPWTRARQALLSSTASRSLVRLMFVASRTLSRHLVLCRPLLLGPSIFPNIRVFSRESSLLMRWPKYWSLSFRICPSSEHSGLISFRMDTFDLLAVHGTLKSLLQQHNSKASILRRSAFLMVQLSLPYITTGKTRALTIRTFVGKVTSLLFKSTTTHKVVLVAVVLLLIQLLIKRIKSWFCCCLMSEQRHSGAQEEACRIRSRTHPARHPVSHWDQPDPSGKLTRRALQPRELSLLLLLAKILESVVVSGIWKQKPHTRRYMANLKSDKAEFPRCFPPAPSSVGCNRYVQIYSASTELLASKLHFANHLRLREHKGRKETFLQPRPKCSHALKNTGKTGTVYFAGTGGQIPFREKRGGELHHLFYNSEREGRAVYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JES4</accession>
    <name>A0A670JES4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JES4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024016.1">
        <property type="protein sequence ID" value="ENSPMRP00000022600.1"/>
        <property type="gene ID" value="ENSPMRG00000014677.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050159">
        <property type="entry name" value="Kazal-type_SerProtInhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001239">
        <property type="entry name" value="Prot_inh_Kazal-m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47499:SF1">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47499">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00290">
        <property type="entry name" value="KAZALINHBTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="117" mass="13369" checksum="9930611490456794" modified="2020-06-17" version="1">MWVHPTPIKDWAFFRSSPDVCSKFPQQEKGKPAGCTKEYRPVCGTNGVTYANLCLFCIMPHAHSMHKYSEHMRYLPSYLWSYLSKQVGFLCSNEATQKSGFLTGGRECCYPCLWSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JFP6</accession>
    <name>A0A670JFP6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GrpE protein homolog 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GRPEL2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JFP6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024318.1">
        <property type="protein sequence ID" value="ENSPMRP00000022890.1"/>
        <property type="gene ID" value="ENSPMRG00000014847.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005589"/>
    <dbReference type="OMA" id="QHELICH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000003">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000004">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF10">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="238" mass="26613" checksum="BBE4BBE2CF0247F4" modified="2020-06-17" version="1">MLNKTGPKTEPCGPPLVTLLQDEEEPLMSTLWVRSVSQPHFTSLSFAFSTAAQQRSTGDDCGPEDPPDEPRHLLNENSLELKATKLEEQVRVLTERYQRALTDSENVRRRTQKFVEDAKIFGIQSFCRDLVEVADILEKTTESTTGGEHDDPTLTLKKICEGLSLIESKLQSIFVKHGLQKMNPIGGKYDPYDHEIVCHVPAEEMQPGTVALVTLDGYKLHGRTIRHAHVGVAVESHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JK33</accession>
    <name>A0A670JK33_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JK33"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024778.1">
        <property type="protein sequence ID" value="ENSPMRP00000023337.1"/>
        <property type="gene ID" value="ENSPMRG00000015151.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286962"/>
    <dbReference type="OMA" id="ASAPICC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="367" mass="41238" checksum="2A60D7BA18D5D7A5" modified="2020-06-17" version="1">MVDHDLLDHRLADVGIQGIARNWLCSFISGRGQRVALGREMSSRHSLVCGVPQGAILSPMLFNIFMRPLAQIIRSFGLGCHQYADDIQLYLLMDGHTDSAPNTLTRCLEAVAGWFRGSRLKLNPSKTEVLWLGWDGMGMRDQLPSLAGAQLVPLPSVKSLGVILDASLSMEAQVTATAKATFFHLRRIKQLVPYLSRPNLATVIHATVISRLDYCNSLYAGLPLKLSQKLQRVQNAAVRLLTGSLPWEHIHPVLFKLHWLPVEYRIRFKVLLLTFKALHGLAPSYLRDRLSWYAPRRASRSINSNTLVVPGPKEVRLASTRARVFSTLAPVWWNALPHETRALQDLISFRRACKTELFRLAFGLEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKN6</accession>
    <name>A0A670JKN6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">WDR70</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat GAD-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028604597.1">
        <property type="nucleotide sequence ID" value="XM_028748764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JKN6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026461.1">
        <property type="protein sequence ID" value="ENSPMRP00000024941.1"/>
        <property type="gene ID" value="ENSPMRG00000016116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606459"/>
    <dbReference type="KEGG" id="pmua:114606459"/>
    <dbReference type="CTD" id="55100"/>
    <dbReference type="GeneTree" id="ENSGT00390000015433"/>
    <dbReference type="OMA" id="KGDQYIT"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001038">
        <property type="entry name" value="WD repeat domain 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000294">
        <property type="entry name" value="WD repeat-containing protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="268"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="643" mass="71255" checksum="AEAC49F73A73A303" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKV4</accession>
    <name>A0A670JKV4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2 G1</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme G1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein G1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">UBE2G1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670JKV4"/>
    <dbReference type="SMR" id="A0A670JKV4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026091.1">
        <property type="protein sequence ID" value="ENSPMRP00000024590.1"/>
        <property type="gene ID" value="ENSPMRG00000015890.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155228"/>
    <dbReference type="OMA" id="MFEWEVM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000018">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="170" mass="19509" checksum="36B61766D995B332" modified="2020-06-17" version="1">MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETIMISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLE7</accession>
    <name>A0A670JLE7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology and RhoGEF domain containing G4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PLEKHG4B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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    <accession>A0A670JPD1</accession>
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        <recommendedName>
            <fullName evidence="11">SET1A methyltransferase</fullName>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
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    <sequence length="781" mass="89113" checksum="024A00F7EF144983" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A670JRX5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028830.1">
        <property type="protein sequence ID" value="ENSPMRP00000027176.1"/>
        <property type="gene ID" value="ENSPMRG00000017530.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154115"/>
    <dbReference type="OMA" id="CMNTFDC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="145"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="476"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="521" mass="59147" checksum="B959ACA08878E16D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSA4</accession>
    <name>A0A670JSA4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myelin regulatory factor like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MYRFL</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028602695.1">
        <property type="nucleotide sequence ID" value="XM_028746862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JSA4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029631.1">
        <property type="protein sequence ID" value="ENSPMRP00000027938.1"/>
        <property type="gene ID" value="ENSPMRG00000018030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605511"/>
    <dbReference type="KEGG" id="pmua:114605511"/>
    <dbReference type="CTD" id="196446"/>
    <dbReference type="GeneTree" id="ENSGT00530000063626"/>
    <dbReference type="OMA" id="CHNPGAS"/>
    <dbReference type="OrthoDB" id="27041at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10144">
        <property type="entry name" value="Peptidase_S74_CIMCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000001">
        <property type="entry name" value="Myelin gene regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025719">
        <property type="entry name" value="MYRF_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF17">
        <property type="entry name" value="MYELIN REGULATORY FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13888">
        <property type="entry name" value="MRF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="10">
        <location>
            <begin position="134"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="11">
        <location>
            <begin position="449"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="7">
        <location>
            <begin position="134"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="894" mass="100702" checksum="F662F1760619AB25" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTJ8</accession>
    <name>A0A670JTJ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC6A16</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
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                <person name="Pereira P."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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    </evidence>
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</entry>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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</entry>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        </location>
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        <source>
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        <source>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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                <person name="Uller T."/>
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                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with both neurexin-alpha and neurexin-beta proteins at the presynaptic membrane. Regulates the balance between excitatory and inhibitory synapses by inhibiting formation of excitatory parallel-fiber synapses and promoting formation of inhibitory synapses in the same neuron. May also be involved in ascorbate (vitamin C) uptake via its interaction with SLC23A2/SVCT2. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts (via cadherin domains) with both alpha and beta isoforms of neurexins (NRXN1, NRXN2 and NRXN3). Directly interacts with APBA2. Forms a tripartite complex with APBA2 and APP. Interacts with low affinity with KLC1. Interacts with SLC23A2/SVCT2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calsyntenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JWV3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029580.1">
        <property type="protein sequence ID" value="ENSPMRP00000027889.1"/>
        <property type="gene ID" value="ENSPMRG00000018007.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183086"/>
    <dbReference type="OMA" id="YTVQCAM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902474">
        <property type="term" value="P:positive regulation of protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051932">
        <property type="term" value="P:synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000025">
        <property type="entry name" value="Calsyntenin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000069">
        <property type="entry name" value="Calsyntenin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000062">
        <property type="entry name" value="Calsyntenin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045588">
        <property type="entry name" value="CLSTN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139">
        <property type="entry name" value="CALSYNTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139:SF5">
        <property type="entry name" value="CALSYNTENIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19699">
        <property type="entry name" value="CLSTN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 23" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 26" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025412348" description="Calsyntenin-3" evidence="26">
        <location>
            <begin position="23"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="27">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="27">
        <location>
            <begin position="149"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="920"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="936"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119414" checksum="597273D27372C90E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXT8</accession>
    <name>A0A670JXT8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CUGBP Elav-like family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CELF5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JXT8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031942.1">
        <property type="protein sequence ID" value="ENSPMRP00000030123.1"/>
        <property type="gene ID" value="ENSPMRG00000019471.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154201"/>
    <dbReference type="OMA" id="QYAAMYP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12632">
        <property type="entry name" value="RRM1_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12635">
        <property type="entry name" value="RRM2_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12639">
        <property type="entry name" value="RRM3_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000007">
        <property type="entry name" value="CUGBP Elav-like family member 4 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000010">
        <property type="entry name" value="CUGBP Elav-like family member 4 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000069">
        <property type="entry name" value="CUGBP Elav-like family member 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034648">
        <property type="entry name" value="CELF3/4/5/6_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="46"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="134"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="386"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030123.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="471" mass="51171" checksum="B78B2FF62E5F876D" modified="2020-06-17" version="1">MARLPASEPRRKAQSQQPPRASPMSSGGGSGGSISEPEGMKDLDAIKLFVGQIPRNLEEKDLKPLFEQFGQIYELTVLKDRYTGMHKGCAFLTYCARDSAIKAQTALHEQKTLPGMARPIQVKPADSESRGGDRKLFVGMLNKQQSEEDILRLFEPFGVIDECTVLRGPDGNSKGCAFVKFSSHTEAQAAIHALHGSQTMPGASSSLVVKFADTDKERTLRRMQQMVGQLGILTPSFALPFTPYSTYAQALMQQQTVLSASHGSFVSPSLTFSPCHIQQIGTVSLNGLPATPVAQTSGLHSPPLLGTTAIPGLVAPITNSFAGVVPIPSTHPTLEAVYTNGLLPCTGRKGERWAVYPATTITPVAQPIPQPLPIIQQQQREGPEGCNLFIYHLPQEFGDNELMQMFLPFGNIISSKVFMDRATNQSKCFGFVSFDNPSSAQTAIQAMNGFQIGMKRLKVQLKRPKDASHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXU6</accession>
    <name>A0A670JXU6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat containing 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LRRC43</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JXU6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029256.1">
        <property type="protein sequence ID" value="ENSPMRP00000027587.1"/>
        <property type="gene ID" value="ENSPMRG00000017764.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008994"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF19">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="566" mass="62932" checksum="F94F952D8F324640" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JYS1</accession>
    <name>A0A670JYS1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aspartate aminotransferase</fullName>
            <ecNumber evidence="14">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70223"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:70225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70295"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="ChEBI" id="CHEBI:140699"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:70297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17441"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57678"/>
            <dbReference type="EC" id="2.6.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:17442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A670JYS1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031518.1">
        <property type="protein sequence ID" value="ENSPMRP00000029716.1"/>
        <property type="gene ID" value="ENSPMRG00000019215.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183082"/>
    <dbReference type="OMA" id="GMEARTY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047801">
        <property type="term" value="F:L-cysteine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF3">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="28"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048761"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049350"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="392" mass="43973" checksum="A358BCAED5FBED31" modified="2025-10-08" version="2">MAAAGVPQAPPVAVFQLTADFRADGDPRKVNLGVGAYRTDEGQPWVLPVVRKVEQMINKDLSLNHEYLPILGLPEFRSNSSRIALGDDSPAIKENRVGGVQSLGGTGALRIGAEFLRRWYNGTNNTATPYQGLRTTTLFFMDAGFKDIRTYRYWDAAKRAPEFSIFVIHACAHNPTGTDPTQEQWKQIAAVMKRRFLFPFFDSAYQGFASGSLDKDAWAVRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVAKDADNVQRTLSQMEKIVRTTWSNPPSQGARIVATTLTTPELFDEWKGNVKTMADRVLLMRAELRSRLEKLQTPGTWNHITEQIGMFSFTGLNPKQVQFMIKEKHIYLMASGRINMCGLTTKNLDYVASSIHEAVTTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZB3</accession>
    <name>A0A670JZB3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Autophagy related 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ATG2A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028566922.1">
        <property type="nucleotide sequence ID" value="XM_028711089.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000029778.1">
        <property type="protein sequence ID" value="ENSPMRP00000028067.1"/>
        <property type="gene ID" value="ENSPMRG00000018117.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587132"/>
    <dbReference type="KEGG" id="pmua:114587132"/>
    <dbReference type="CTD" id="23130"/>
    <dbReference type="GeneTree" id="ENSGT00620000087966"/>
    <dbReference type="OMA" id="RPCAQIH"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044232">
        <property type="term" value="C:organelle membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120013">
        <property type="term" value="F:lipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF21">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 2 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1386"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1503"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1564"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1689"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1408"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1515"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1529"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1692"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1715"/>
            <end position="1732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="2013" mass="220889" checksum="D02D8276C5F2F82F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZT9</accession>
    <name>A0A670JZT9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Apolipoprotein A-IV</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Apolipoprotein A4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">APOA4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apolipoprotein A1/A4/E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JZT9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030586.1">
        <property type="protein sequence ID" value="ENSPMRP00000028834.1"/>
        <property type="gene ID" value="ENSPMRG00000018646.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182929"/>
    <dbReference type="OMA" id="IININCE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042627">
        <property type="term" value="C:chylomicron"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034362">
        <property type="term" value="C:low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034361">
        <property type="term" value="C:very-low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060228">
        <property type="term" value="F:phosphatidylcholine-sterol O-acyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055090">
        <property type="term" value="P:acylglycerol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034371">
        <property type="term" value="P:chylomicron remodeling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034375">
        <property type="term" value="P:high-density lipoprotein particle remodeling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002227">
        <property type="term" value="P:innate immune response in mucosa"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007159">
        <property type="term" value="P:leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034445">
        <property type="term" value="P:negative regulation of plasma lipoprotein oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033700">
        <property type="term" value="P:phospholipid efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045723">
        <property type="term" value="P:positive regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010898">
        <property type="term" value="P:positive regulation of triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065005">
        <property type="term" value="P:protein-lipid complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032374">
        <property type="term" value="P:regulation of cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030300">
        <property type="term" value="P:regulation of intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006982">
        <property type="term" value="P:response to lipid hydroperoxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035634">
        <property type="term" value="P:response to stilbenoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043691">
        <property type="term" value="P:reverse cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034372">
        <property type="term" value="P:very-low-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.20:FF:000001">
        <property type="entry name" value="apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.20">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000074">
        <property type="entry name" value="ApoA_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF1">
        <property type="entry name" value="APOLIPOPROTEIN A-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01442">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0162">Chylomicron</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="340" mass="39056" checksum="E326EA342B75AF5D" modified="2020-06-17" version="1">MGNNAKETVEQVQQSEISKRLNTLFQDNFQALNTYAGELQNKLVPFATDMHLRLAEDSEKLKQQIQEEMQQLRARLAPHADDVHSAISKNIQELQAKLAPYAEELKTQVNQNAGELRRKLEPLAQQVQAKLQENMGSLQTSLSPYADELQQQVNQKVEDIKGSLTPYADELKAKVDQTMAELRNSLSPYTQDVQEQLNHQLEGLSFQMKKSIEDLRAQLLERTEDLQLKLSPLAQELREKLQGDAADLRESLTPYMEGLNKKMDQQIEEFRQVVGPYGENFNRLLVQKVEEMKKKLKPYAGETEDHLSFLEKDVRDRFNSFFDSLKQMANEKAPLPALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K1I8</accession>
    <name>A0A670K1I8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Bromodomain and PHD finger containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BRPF1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028575547.1">
        <property type="nucleotide sequence ID" value="XM_028719714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K1I8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032477.1">
        <property type="protein sequence ID" value="ENSPMRP00000030621.1"/>
        <property type="gene ID" value="ENSPMRG00000019830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591942"/>
    <dbReference type="CTD" id="7862"/>
    <dbReference type="GeneTree" id="ENSGT00940000157794"/>
    <dbReference type="OMA" id="PDYMDIV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043997">
        <property type="term" value="F:histone H4K12 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043995">
        <property type="term" value="F:histone H4K5 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043996">
        <property type="term" value="F:histone H4K8 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05512">
        <property type="entry name" value="Bromo_brd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15701">
        <property type="entry name" value="ePHD_BRPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15676">
        <property type="entry name" value="PHD_BRPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20156">
        <property type="entry name" value="PWWP_BRPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000007">
        <property type="entry name" value="Bromodomain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042008">
        <property type="entry name" value="BRPF1_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049583">
        <property type="entry name" value="BRPF1_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042061">
        <property type="entry name" value="Peregrin_ePHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF85">
        <property type="entry name" value="PEREGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
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            <begin position="58"/>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
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        <source>
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        <source>
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            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1222" mass="138665" checksum="5F5AFFD2BB051AAD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K1K3</accession>
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            <fullName evidence="9">G protein-coupled receptor class C group 5 member B</fullName>
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        <name evidence="9" type="primary">GPRC5B</name>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Feiner N."/>
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                <person name="Pauperio F."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <location>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K1X6</accession>
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        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K1X6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033458.1">
        <property type="protein sequence ID" value="ENSPMRP00000031543.1"/>
        <property type="gene ID" value="ENSPMRG00000020429.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017863"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="173"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="583" mass="66514" checksum="E8C2CC10C4C064C2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3D7</accession>
    <name>A0A670K3D7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Shisa family member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SHISA8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028602997.1">
        <property type="nucleotide sequence ID" value="XM_028747164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K3D7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033190.1">
        <property type="protein sequence ID" value="ENSPMRP00000031291.1"/>
        <property type="gene ID" value="ENSPMRG00000020282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605678"/>
    <dbReference type="KEGG" id="pmua:114605678"/>
    <dbReference type="CTD" id="440829"/>
    <dbReference type="GeneTree" id="ENSGT00940000163663"/>
    <dbReference type="OMA" id="NPTRDKT"/>
    <dbReference type="OrthoDB" id="9996010at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032591">
        <property type="term" value="C:dendritic spine membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053891">
        <property type="entry name" value="Shisa_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31774:SF14">
        <property type="entry name" value="PROTEIN SHISA-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31774">
        <property type="entry name" value="PROTEIN SHISA-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13908">
        <property type="entry name" value="Shisa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025496338" evidence="7">
        <location>
            <begin position="31"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Shisa N-terminal" evidence="8">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="404" mass="44422" checksum="CC9C63BAACE5DB91" modified="2020-06-17" version="1">MMSWGGLQMERGYIFGFCCLVLLDPGQVWTGNPSTQKPEPEAQIEVNSNTSFGPTLEDTAVATTEAILGGDRCLGYYDVMGQWDPPFNCNSGIYKFCCGTCGYRFCCQFTTGRLDQSGCTNYDRPEWINTGQPPPQVDETPENPTRDKTNMIVYIICGVVAIMVLVGIFTKLGLEKSQSPQAEMTMSRTLTDLLKQPGGHGPSDILPESHIGSVQVQISDGFSRSPRNSTDKNHLNNAVVNPSSVSQIGLSHSHNNRLQMASTMPHQAPDYAKYATLKAVESAPEEFYKRFPVVDMPPSATLSFPPLTLHQKDVSPYQDGCALIGLATPGQKAKVMKASAHTLAGSPAFKPGWDPNHPDLRRQAYTTKRQFSIEKLPEVFSQTPTHYAQQQRPFSTNSKTEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3Z2</accession>
    <name>A0A670K3Z2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">28S rRNA (uridine-N(3))-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Centromere protein 32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Kinetochore-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">SPOUT domain-containing methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N3 position of a uridine in 28S rRNA. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uridine in 28S rRNA + S-adenosyl-L-methionine = N(3)-methyluridine in 28S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83635"/>
            <dbReference type="Rhea" id="RHEA-COMP:20178"/>
            <dbReference type="Rhea" id="RHEA-COMP:20181"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:83636"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with INCA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K3Z2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034201.1">
        <property type="protein sequence ID" value="ENSPMRP00000032258.1"/>
        <property type="gene ID" value="ENSPMRG00000020910.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016537"/>
    <dbReference type="OMA" id="YGYHVRI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051661">
        <property type="term" value="P:maintenance of centrosome location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035196">
        <property type="term" value="P:miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000170">
        <property type="entry name" value="SPOUT domain containing methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="371" mass="41398" checksum="0EAEF173FFA1894D" modified="2020-06-17" version="1">MVEKSREKTGQWPGANGSRKRRRRRKKWKELKLLRKLEKKMMQEVAEKQKEEAKPIEDKGCNYTVSVALPGSMLSNAQSAELRTYLAGQIARACVIFCVDEIVVFDEHGEDSKMVEGEIEGIKKRDQACVQLAQILQYLECPQYLRKSFPPKHQDLKFAGLLNPLDSPHHVRIGEESEYREGVVLSRPTKPGRGSFVNCGMQKEVQIDKQLEAGLCVTVRLNPQQNPESKTQKGMVVSSHQPRTASGLYWGHSVRLASCLSAVFAESPYKEGYNLSIGTSERGTSVDQATLTPFRHALIVFGGLQGLEASVDTDLNLEVTDTSTLFDFYLNTCPGQGSCIIRTEEAILISLSALRPQINGAVKKAKRTIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5Y7</accession>
    <name>A0A670K5Y7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670K5Y7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032085.1">
        <property type="protein sequence ID" value="ENSPMRP00000030257.1"/>
        <property type="gene ID" value="ENSPMRG00000019561.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047493"/>
    <dbReference type="OMA" id="QYKFRPN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="144" mass="15704" checksum="3E687F55BEDA17D9" modified="2020-06-17" version="1">MKSAFVTVGTTSFDDLIAAVTAPEALQVLQDLGYSRLVLQVGRGTVCPVSTSTPTFTLEVFRFKNSLSEDVQIADLVISHAGAGSCLEVLEAGKPLLVVVNDKLMDNHQLELARQLCRDGHLFYCTYHKTNLVFGGGKQEKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6M5</accession>
    <name>A0A670K6M5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CBFA2/RUNX1 partner transcriptional co-repressor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CBFA2T2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K6M5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033857.1">
        <property type="protein sequence ID" value="ENSPMRP00000031925.1"/>
        <property type="gene ID" value="ENSPMRG00000020681.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183176"/>
    <dbReference type="OMA" id="WKHLDHX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060575">
        <property type="term" value="P:intestinal epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000001">
        <property type="entry name" value="CBFA2/RUNX1 translocation partner 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1110:FF:000001">
        <property type="entry name" value="RUNX1 translocation partner 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1110">
        <property type="entry name" value="TAFH/NHR1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013289">
        <property type="entry name" value="CBFA2T1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014896">
        <property type="entry name" value="NHR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037249">
        <property type="entry name" value="TAFH/NHR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003894">
        <property type="entry name" value="TAFH_NHR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379">
        <property type="entry name" value="MTG8 ETO EIGHT TWENTY ONE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379:SF13">
        <property type="entry name" value="PROTEIN CBFA2T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08788">
        <property type="entry name" value="NHR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07531">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01875">
        <property type="entry name" value="ETOFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00549">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158553">
        <property type="entry name" value="TAFH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51119">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAFH" evidence="13">
        <location>
            <begin position="102"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="496"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="561" mass="62319" checksum="4197CAEF7857026C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K971</accession>
    <name>A0A670K971_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MTMR4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670K971"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036185.1">
        <property type="protein sequence ID" value="ENSPMRP00000034118.1"/>
        <property type="gene ID" value="ENSPMRG00000020964.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158976"/>
    <dbReference type="OMA" id="TRWLQHM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15733">
        <property type="entry name" value="FYVE_MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13342">
        <property type="entry name" value="PH-GRAM_MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14587">
        <property type="entry name" value="PTP-MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000073">
        <property type="entry name" value="myotubularin-related protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046978">
        <property type="entry name" value="MTMR4_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035997">
        <property type="entry name" value="MTMR4_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030590">
        <property type="entry name" value="MTMR4_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF64">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="17">
        <location>
            <begin position="157"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="380"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="16">
        <location>
            <begin position="1065"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="647"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="781"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="973"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="690"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="10">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="324"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="349"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="411"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1146" mass="128403" checksum="992AE0C6CF547B69" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K997</accession>
    <name>A0A670K997_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ectonucleoside triphosphate diphosphohydrolase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ENTPD8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028571491.1">
        <property type="nucleotide sequence ID" value="XM_028715658.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028571492.1">
        <property type="nucleotide sequence ID" value="XM_028715659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K997"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035392.1">
        <property type="protein sequence ID" value="ENSPMRP00000033361.1"/>
        <property type="gene ID" value="ENSPMRG00000021631.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589333"/>
    <dbReference type="KEGG" id="pmua:114589333"/>
    <dbReference type="CTD" id="377841"/>
    <dbReference type="GeneTree" id="ENSGT01150000286965"/>
    <dbReference type="OMA" id="QWPEEKE"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009133">
        <property type="term" value="P:nucleoside diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 8"/>
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            <begin position="209"/>
            <end position="213"/>
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        <source>
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    </evidence>
    <sequence length="495" mass="55028" checksum="C4DA58EF048AC617" modified="2020-06-17" version="1">MGNRWSNWYPPAALVILSMFSLTALLLIVVGNHNVTLPPDNKYGLVFDAGSSHTSLFVYQWPMDKENNTGVVSQTFSCHVNGSGISSYAKNPPQAGASLKECLDAAMTVIPPERQQETPAYLGATAGMRLLRMENESASKQVLEEVGKTIKQYPVSFRGAQIISGEDEGAYGWITINYLLDSFTKYSAKDREWIHPTSTNILGALDLGGASTQISFVPAGKITDPNEAAHFRLYGFDYTIYTHSYLCYGQNQALQHLTRIIINSSSSDRVDHPCYPEGYISSFTTASVYSSPCAKQSMPPPASKNFTLVGTGNATLCRETFKSIFNFSKNCKYNDSCGFNGVYQPKVNGKFLAFSAYYYTFNFLNLTETQPLATVEDTIKTFCARKWDELKSSYSSEKEDHLKNYCASANYILTILLDGYGFRTDTWNNIAFRMRAANSEIGWTLGYMLNLTNMIPAEAPRQLRGHEEGVWAASIFFIAAVLAICIALLVMYLLR</sequence>
</entry>
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        <name evidence="3" type="primary">SPP1</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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</entry>
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    <accession>A0A670K9K0</accession>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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                <person name="While G.M."/>
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                <person name="Andersson L."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00390000008250"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:mitotic spindle microtubule"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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            <end position="524"/>
        </location>
    </feature>
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            <end position="901"/>
        </location>
    </feature>
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        <location>
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            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="918" mass="102351" checksum="6538B92C7FB99DB3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9L0</accession>
    <name>A0A670K9L0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Golgi phosphoprotein 3 like</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">GOLPH3L</name>
    </gene>
    <organism evidence="8 9">
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        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028565948.1">
        <property type="nucleotide sequence ID" value="XM_028710115.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565950.1">
        <property type="nucleotide sequence ID" value="XM_028710117.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565951.1">
        <property type="nucleotide sequence ID" value="XM_028710118.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565952.1">
        <property type="nucleotide sequence ID" value="XM_028710119.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565953.1">
        <property type="nucleotide sequence ID" value="XM_028710120.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565954.1">
        <property type="nucleotide sequence ID" value="XM_028710121.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565955.1">
        <property type="nucleotide sequence ID" value="XM_028710122.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028565956.1">
        <property type="nucleotide sequence ID" value="XM_028710123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K9L0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034227.1">
        <property type="protein sequence ID" value="ENSPMRP00000032274.1"/>
        <property type="gene ID" value="ENSPMRG00000020922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586521"/>
    <dbReference type="CTD" id="55204"/>
    <dbReference type="GeneTree" id="ENSGT00390000007153"/>
    <dbReference type="OMA" id="KEXGYTS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140312">
        <property type="term" value="F:cargo adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140450">
        <property type="term" value="P:protein targeting to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000001">
        <property type="entry name" value="Golgi phosphoprotein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF4">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="285" mass="32553" checksum="0F162E3D1C765ADA" modified="2020-06-17" version="1">MTTLIHRGRRADVGRNVDKRLEGEEDSIPDKNLGEEDSGDSKDIRLTLMEEVLLLGLKDKEGYTSFWNDCISSGLRGGILIELAMRGRIQLEPQTMRKKRLLDRKVLLKSDAPTGDVLLDETLRHLKATEPAETVQTWIELLTGETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQESVLDRWVNDPHRMDRRTLALLVLAHASDVLENVFTSLVDEKYDVAMNRSKDLMDRDPEAEAAKAGGSEMIWAVLAAFNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBH0</accession>
    <name>A0A670KBH0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KBH0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036208.1">
        <property type="protein sequence ID" value="ENSPMRP00000034141.1"/>
        <property type="gene ID" value="ENSPMRG00000022145.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158577"/>
    <dbReference type="OMA" id="KVIVKQM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17102">
        <property type="entry name" value="FERM_F1_FRMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000002">
        <property type="entry name" value="Erythrocyte protein band 4.1-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000006">
        <property type="entry name" value="FERM domain-containing protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
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        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF8">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="179" mass="21280" checksum="63DA3B055EF8A22B" modified="2020-06-17" version="1">GTCYCIYQPTFPLNEILKMSDTNKLASQSSETKGQFLIDHVCNHYSLLEKDYFGIRYVDPEKQRHWLEPNKAISKQMKSHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAFLGACIVQAEFGDYDPDEHLDNYVSEFKIFPKQSQKLERKILDIHKNEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDX6</accession>
    <name>A0A670KDX6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline rich 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PRR22</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KDX6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036688.1">
        <property type="protein sequence ID" value="ENSPMRP00000034585.1"/>
        <property type="gene ID" value="ENSPMRG00000022432.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016128"/>
    <dbReference type="OMA" id="RIEWTTP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031535">
        <property type="entry name" value="PRR22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37871">
        <property type="entry name" value="PROLINE-RICH PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37871:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15776">
        <property type="entry name" value="PRR22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="379" mass="40814" checksum="059E2F3CA967AE97" modified="2020-06-17" version="1">MAPCGCFFDPRIYRIEWATANFVQPSVYKLSGAPGPQNTYLLDGQKYLKSPVQPVAYPPYQPVASNPPFVLPFFKPEGPSSHLADHMGFVGSPAHSSPFAEVVSLHSEGPGQSKERKLLSTLPGLNPSERPALAAAYEPLKDCHNLAFQAFKDFQADEADDVRNPDFAEDPPALPNVSPEDHQAILGAPTADIMPEAESCMDLESIIAAGNALIEEEEASFNLPEKVLLEDAMKLFDCSPVNSDTEASLDGLGNGRHSRHCGDSLRDSCFSGEDSTSDIRSLNLPDELLSFDYSVPEILSAVTSLDYLYDVNAFGEESQWEARPPSQPPLQHESHMGLEEKAKSGVAKKNKPAAGQSKVASVQGGDGEPQGQDSTSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFB3</accession>
    <name>A0A670KFB3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribitol-5-phosphate transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FKTN</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LicD transferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028568498.1">
        <property type="nucleotide sequence ID" value="XM_028712665.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028568499.1">
        <property type="nucleotide sequence ID" value="XM_028712666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KFB3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037113.1">
        <property type="protein sequence ID" value="ENSPMRP00000035000.1"/>
        <property type="gene ID" value="ENSPMRG00000022645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587842"/>
    <dbReference type="KEGG" id="pmua:114587842"/>
    <dbReference type="CTD" id="2218"/>
    <dbReference type="GeneTree" id="ENSGT00390000014471"/>
    <dbReference type="OMA" id="ICKWATH"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071711">
        <property type="term" value="P:basement membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021695">
        <property type="term" value="P:cerebellar cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098528">
        <property type="term" value="P:skeletal muscle fiber differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045587">
        <property type="entry name" value="FKTN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19737">
        <property type="entry name" value="FKTN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Ribitol-5-phosphate transferase FKTN N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="8">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="461" mass="53962" checksum="9216CBF2E5C59772" modified="2020-06-17" version="1">MQRINKNVVLGLLTLTSSVFLLFQLYYYKYYLSPRNGAVFPKIKGNKAGQDGSRWHVVKKFISLMSSHNIPVHLIDPLLLGLIDTDLKQLRTSPDSSHSECRYLCARRDFTTFAVLDKAWKLEVGLFRAAERVGFQWLKLQSKDPRLEGMDDLSGMEIPLHYIFRLAAHAIHLVVFYERSGNYLWHGQLRLKRHMDRKFVPFRKLPFGRYPGAYDKLELISVSMDGLTVQIPKEPSQFLEERSHSRFIECRYREARSFFQLYPDDVSLDSVEFRKKAKALLHLASLTLNSLGVRFWLSSGTCLGWYRQCNIIPYSKDVDLGIFIQDYQPDIIPAFQKAGLPLKHKFGKVEDSLELSFQGEDEVKLDIFFFYEEDDHVWNGGTQAKSGKKFKYLFPKFTLCWTEFVELKVRVPCETLHYIEANYGKEWKIPVKMWDWKNSPPNVQPNGIWPINEWEEVIQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFJ6</accession>
    <name>A0A670KFJ6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratin, type II cytoskeletal 6A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114593004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028577298.1">
        <property type="nucleotide sequence ID" value="XM_028721465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KFJ6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037193.1">
        <property type="protein sequence ID" value="ENSPMRP00000035075.1"/>
        <property type="gene ID" value="ENSPMRG00000022705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593004"/>
    <dbReference type="KEGG" id="pmua:114593004"/>
    <dbReference type="GeneTree" id="ENSGT00940000155862"/>
    <dbReference type="OMA" id="TNLEPMF"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF19">
        <property type="entry name" value="KERATIN 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="129"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="338"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="525" mass="57229" checksum="0C5483A8B85E56F8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGL3</accession>
    <name>A0A670KGL3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel tetramerization domain containing 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KCTD5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KGL3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038286.1">
        <property type="protein sequence ID" value="ENSPMRP00000036131.1"/>
        <property type="gene ID" value="ENSPMRG00000023342.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160374"/>
    <dbReference type="OMA" id="DLDSDKX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein-containing complex binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18390">
        <property type="entry name" value="BTB_POZ_KCTD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2000:FF:000001">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000005">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="70"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="272" mass="29523" checksum="6E27ADB8EAFD62D7" modified="2020-06-17" version="1">MAAEGSCELPVVPAAGLGLSGAPSASCRRCSSSSSSSSSSFSSPSSSSSSSCGGCLAPPAPPVAGGVPGKWVRLNVGGTCFLTTRQTLCRDPKSFLFRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKISQVPVKHVYRVLQCQEEELTQMVSTMSDGWKFEQLVSIGSSYNYGNEDQAEFLCVVSKELHNTPYGTASEPSEKAKVSHLQVSRLIYVCQHRHTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJG9</accession>
    <name>A0A670KJG9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Bone morphogenetic protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BMP3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 15">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028600174.1">
        <property type="nucleotide sequence ID" value="XM_028744341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KJG9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037929.1">
        <property type="protein sequence ID" value="ENSPMRP00000035784.1"/>
        <property type="gene ID" value="ENSPMRG00000023119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604313"/>
    <dbReference type="KEGG" id="pmua:114604313"/>
    <dbReference type="CTD" id="651"/>
    <dbReference type="GeneTree" id="ENSGT00940000159775"/>
    <dbReference type="OMA" id="HWGTINN"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070700">
        <property type="term" value="F:BMP receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030279">
        <property type="term" value="P:negative regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000008">
        <property type="entry name" value="Bone morphogenetic protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017197">
        <property type="entry name" value="BMP3/BMP3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF144">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037403">
        <property type="entry name" value="BMP3/GDF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00669">
        <property type="entry name" value="INHIBINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5 13" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13 15" id="KW-0339">Growth factor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025720902" description="Bone morphogenetic protein 3" evidence="13">
        <location>
            <begin position="24"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="17">
        <location>
            <begin position="359"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="369"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="398"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="402"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="14">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="471" mass="52914" checksum="9C8590B228ED313C" modified="2020-06-17" version="1">MAGAPRALLLLCLGLSWSLLVAPEEPALERTGGLRKRSRAAAALAAGDQPAPLVVSPEDKVSEHMLRLYDRYSGGRPEESAPGAPQLLHLREGNTVRSFRALPAGIPGNKEVRVFNLTSLTKSENILSALLHYYVGDLQNNSNNCPHIKGCSRHGHRKPDMQISLSLLSFPPSGNQTRTLGHYSINVSTAFRDVLSWQWKNITQVLSKAKQNNDLLIGVKMAAIGRHTWKNVHPSYEPYILVYANDSAISEPESVVSSLQGHWSPLPASFPKLDSHLKRGLGERRQKRSTGVLLPLQNNELPGAEYQYSEDEGWEERKHYKTLQPRLAERAKNKKKQRKNNHQKSQTLQFDEQTLKKARRKQWNEPRYCTRRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKPSNHATIQSIVRAVGVVSGIPEPCCVPDKMSSLSILFFDENKNVVLKVYPNMTVESCACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKB3</accession>
    <name>A0A670KKB3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Shiftless antiviral inhibitor of ribosomal frameshifting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SHFL</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHFL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KKB3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038955.1">
        <property type="protein sequence ID" value="ENSPMRP00000036785.1"/>
        <property type="gene ID" value="ENSPMRG00000023692.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005065"/>
    <dbReference type="OMA" id="PVPKDKM"/>
    <dbReference type="OrthoDB" id="9423182at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001125">
        <property type="term" value="P:negative regulation of translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035456">
        <property type="term" value="P:response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034340">
        <property type="term" value="P:response to type I interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034341">
        <property type="term" value="P:response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034342">
        <property type="term" value="P:response to type III interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026795">
        <property type="entry name" value="SHFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16135">
        <property type="entry name" value="REPRESSOR OF YIELD OF DENV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16135:SF2">
        <property type="entry name" value="SHIFTLESS ANTIVIRAL INHIBITOR OF RIBOSOMAL FRAMESHIFTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15135">
        <property type="entry name" value="UPF0515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="305" mass="34982" checksum="DB2FFF112D46EB21" modified="2020-06-17" version="1">MHRARQDEVELEKSVRRLREKFYGKVSIKTATVLMRQFCNNHELACSRIILCKNELEDTDPEDGESLDDDPVALRVVDKLEQEEEQKKQKRNDKSDEKIKEVAQQLKCLPLTQKNLRMFDNAEKNRIPPEDRQFSCQPCDSMWWRRVPKRKQVSRCHLCGNKYDPVPEDKMWGTAEFTCPSCGRTFSGSAQMGTPSPCYSCHSPVLPSFIIPPRKKLGPRSRQQHSCFAEDCYNRREPHIPGTHCVHPQSRVKNSLPKVIYPSQEHDSTGSTVATCLSQGSLAFCDINELILEDLKEEEAGESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKP8</accession>
    <name>A0A670KKP8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC4A2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate(in) + chloride(out) = hydrogencarbonate(out) + chloride(in)</text>
            <dbReference type="Rhea" id="RHEA:72363"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KKP8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038546.1">
        <property type="protein sequence ID" value="ENSPMRP00000036379.1"/>
        <property type="gene ID" value="ENSPMRG00000023397.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158259"/>
    <dbReference type="OMA" id="RYQRMPT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015701">
        <property type="term" value="P:bicarbonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030316">
        <property type="term" value="P:osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000004">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001717">
        <property type="entry name" value="Anion_exchange"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018241">
        <property type="entry name" value="Anion_exchange_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF14">
        <property type="entry name" value="ANION EXCHANGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00165">
        <property type="entry name" value="ANIONEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00220">
        <property type="entry name" value="ANION_EXCHANGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0039">Anion exchange</keyword>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="810"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1007"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1067"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1093"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="15">
        <location>
            <begin position="303"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="14">
        <location>
            <begin position="664"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1217" mass="135765" checksum="636DFF64CBA435D0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KNU0</accession>
    <name>A0A670KNU0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KNU0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038858.1">
        <property type="protein sequence ID" value="ENSPMRP00000036687.1"/>
        <property type="gene ID" value="ENSPMRG00000023638.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165416"/>
    <dbReference type="OMA" id="TQQIKQT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000115">
        <property type="entry name" value="Calcium-binding protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051111">
        <property type="entry name" value="Ca-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311:SF1">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="205" mass="23187" checksum="F3D537559A94275C" modified="2020-06-17" version="1">MPFHPVTAALMYRGIYTIPNILATEQHPVDIPEDELEEIREAFKVFDRDGNGFISKQELGTAMRSLGYMPNEVELEVIIQRLDMDGKTFWRGVGKVLDAPPPLFLHAMDSGACDMQKLTVDELKRLLYDTFCEHLSMKDIENIIMTEEESHMGNAEECPVDVETCSNQQIRQTCVRKSLICAFAIAFIISVMLIAANQVLRSGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HND9</accession>
    <name>A0A670HND9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670HND9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000539.1">
        <property type="protein sequence ID" value="ENSPMRP00000000512.1"/>
        <property type="gene ID" value="ENSPMRG00000000382.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163417"/>
    <dbReference type="OMA" id="HIVIPRY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF38">
        <property type="entry name" value="LRRGT00076-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RT_POL"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="4">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="198"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="338" mass="37343" checksum="8F53E3E50E8A61CD" modified="2020-06-17" version="1">MVSVKEGSRFVDFMVDTGAQYSVLTKPLKAKSNQAITIVGATGNQTAKPFLQPQECQIGGKTLTHQFIYVPECPIPLLGCDFLAKIQAQVTFTPKGAELKLPPEATGIVTVTVPREQAWQMMMALSEINPHEQKLQPLPKTLQAPLGVWAEDNPPSMAKNIAPIVVALKPGARPVAIQQYRIPRQAAEGIQIHINRLLKYGLLKRCQSFWNTPLLPVGKPNTNDYRPVQDLREVNRATETLHPNVPNPYNILGLIPAEATVFTVLDLKDAFFCCQLAPQSQPIFAFQWADPHIRSKGQLTWTCLPQGFKNSPTLLGTALAQDLAKFSSVPREKVSFCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP92</accession>
    <name>A0A670HP92_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HP92"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001574.1">
        <property type="protein sequence ID" value="ENSPMRP00000001483.1"/>
        <property type="gene ID" value="ENSPMRG00000001109.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051517">
        <property type="entry name" value="IFITM_antiviral_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13999">
        <property type="entry name" value="INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="97" mass="10991" checksum="F6A76BDFC5127745" modified="2020-06-17" version="1">MQTAPHHPSPSTMQPHDERPRPATKDYVLWSLFSFSFLNACCLGFAALVFSIKVRNHVFGPWSGQEAVDPSFLIRASKPHFWALEWPGSRGSEFFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRL6</accession>
    <name>A0A670HRL6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenosine deaminase tRNA specific 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADAT2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HRL6"/>
    <dbReference type="SMR" id="A0A670HRL6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002491.1">
        <property type="protein sequence ID" value="ENSPMRP00000002343.1"/>
        <property type="gene ID" value="ENSPMRG00000001696.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000280"/>
    <dbReference type="OMA" id="THNGHIV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
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        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="128" mass="14458" checksum="37ADA38F84BD826B" modified="2020-06-17" version="1">MEAEKGRAVTAGEREAWMDLAVNMAKEALESGEVPVGCLMVYNNEIIGKGKNEVNETKNATRHAEMVAIDQVMDWCRQNKKEPKEVFANTVLYVTVEPCIMCAAALRMMSILWRIIHWYVNFISCIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HSN4</accession>
    <name>A0A670HSN4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HSN4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002899.1">
        <property type="protein sequence ID" value="ENSPMRP00000002713.1"/>
        <property type="gene ID" value="ENSPMRG00000001954.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189748"/>
    <dbReference type="OMA" id="HMHILAC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF32">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN CONTAINING 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="77" mass="8677" checksum="936CDDADA284E596" modified="2020-06-17" version="1">MEKSGNIQLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQAFRAHKVVLAASSPYFRDHMSLNEMISVTTQPIKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HT26</accession>
    <name>A0A670HT26_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Collagen alpha-2(VI) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">COL6A2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Collagen VI acts as a cell-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the type VI collagen family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028558981.1">
        <property type="nucleotide sequence ID" value="XM_028703148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HT26"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003063.1">
        <property type="protein sequence ID" value="ENSPMRP00000002858.1"/>
        <property type="gene ID" value="ENSPMRG00000002061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582255"/>
    <dbReference type="KEGG" id="pmua:114582255"/>
    <dbReference type="CTD" id="1292"/>
    <dbReference type="GeneTree" id="ENSGT00940000155682"/>
    <dbReference type="OMA" id="LIFRPME"/>
    <dbReference type="OrthoDB" id="9944853at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000027">
        <property type="entry name" value="collagen alpha-2(VI) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000052">
        <property type="entry name" value="collagen alpha-2(VI) chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000026">
        <property type="entry name" value="Collagen, type VI, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052229">
        <property type="entry name" value="Collagen-VI/PIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588:SF15">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025624932" description="Collagen alpha-2(VI) chain" evidence="14">
        <location>
            <begin position="21"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="41"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="617"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="835"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1024" mass="108325" checksum="C140034FF2ED115C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTR4</accession>
    <name>A0A670HTR4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HTR4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002804.1">
        <property type="protein sequence ID" value="ENSPMRP00000002635.1"/>
        <property type="gene ID" value="ENSPMRG00000001891.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="CHARYLW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="38069" checksum="2C5B62A8F20B1793" modified="2020-06-17" version="1">MVAPEQSLTKTLQNYFKENDVNNTTTPLLWDAMKAVTRGACIKEKTFLKKQTSSKIKLNAFAMVSGLQVNFTKSEAMCFNTPPHTQKELTKVTKIKLCHTKFRYLGVQITRNLNKLYLHNYKPLWRQINKDLKRWNNMNLTLSDKIAMIKMTTLPKLTYLFQTLPIWIPSTQLHSWQRKLHSFIFSHKKPRISPKYLHLPTSEGGWGIPNIEAYYTANQIRHIIPYILEDETKQWVHLERDTIENTCTTTYPLLPDKLRKIPTTLNRYTQTMLKAWKTQIGGLKWCPFFLVGHLLKWHTLPTFQVYMKWLCGAMPIDARFILHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUY0</accession>
    <name>A0A670HUY0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology domain containing B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PLEKHB1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HUY0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003108.1">
        <property type="protein sequence ID" value="ENSPMRP00000002902.1"/>
        <property type="gene ID" value="ENSPMRG00000002089.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013989"/>
    <dbReference type="OMA" id="FLWMPFL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13265">
        <property type="entry name" value="PH_evt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000073">
        <property type="entry name" value="Pleckstrin homology domain-containing family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF7">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="191" mass="22089" checksum="ECE6E472AFEC313B" modified="2020-06-17" version="1">MALLKCGWLWRQSSILRRWKRNWFVLWVDGTLVYYHDDTGRDMDGRINIKFNCRDVRTGRECRDIPPPEGRTRECLMCIVQRDGSKTMLCAESEDDAVAWKIAILEAKATQVHLYDPYDDYYQTVPLDSHQAMYVSSDYYGNQYGATHVIFREDPYRVSGDQMVAQPEHGKLGSNSLKAAICMCRGAIEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXS8</accession>
    <name>A0A670HXS8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta 3-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">B3GLCT</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HXS8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004260.1">
        <property type="protein sequence ID" value="ENSPMRP00000003990.1"/>
        <property type="gene ID" value="ENSPMRG00000002733.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000004270.1">
        <property type="protein sequence ID" value="ENSPMRP00000004000.1"/>
        <property type="gene ID" value="ENSPMRG00000002733.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000004290.1">
        <property type="protein sequence ID" value="ENSPMRP00000004020.1"/>
        <property type="gene ID" value="ENSPMRG00000002733.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155499"/>
    <dbReference type="OMA" id="CATYPRF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160265">
        <property type="term" value="F:O-fucosylpeptide 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904888">
        <property type="term" value="P:cranial skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060173">
        <property type="term" value="P:limb development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036066">
        <property type="term" value="P:protein O-linked glycosylation via fucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000008">
        <property type="entry name" value="Beta-1,3-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000070">
        <property type="entry name" value="Beta-1,3-glucosyltransferase-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="179"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="330"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="563" mass="63820" checksum="43461370E39203E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1S2</accession>
    <name>A0A670I1S2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase OMA1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Overlapping with the m-AAA protease 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OMA1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooligomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I1S2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006277.1">
        <property type="protein sequence ID" value="ENSPMRP00000005903.1"/>
        <property type="gene ID" value="ENSPMRG00000004001.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007027"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
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        <property type="entry name" value="Peptidase_M48"/>
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        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00040360"/>
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        <source>
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    <sequence length="517" mass="59641" checksum="5ACED61EDA91F2A6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I395</accession>
    <name>A0A670I395_PODMU</name>
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        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial</fullName>
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        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase SGDH subunit</fullName>
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    </protein>
    <gene>
        <name evidence="18" type="primary">NDUFB5</name>
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    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB5 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I395"/>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SGDH SUBUNIT"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF09781">
        <property type="entry name" value="NDUF_B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="20"/>
            <end position="40"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="136" mass="16131" checksum="9A547273CEB5A1A8" modified="2020-06-17" version="1">MFVIQATDFYDRRFLLLLRFYILLTGIPVALIITFVNVFIGKAELAEIPEGYVPEHWEYYRHPITRWIARNLLDPPEKDYEKGLAYLYAESEKLELRKQEKTARRLMQQRGDGPWHFYETTPASLIDYSNKATPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4E6</accession>
    <name>A0A670I4E6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I4E6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006691.1">
        <property type="protein sequence ID" value="ENSPMRP00000006285.1"/>
        <property type="gene ID" value="ENSPMRG00000004240.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234549"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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        <location>
            <begin position="70"/>
            <end position="309"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006285.1"/>
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            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="331" mass="36346" checksum="FC9A1B9EE505A602" modified="2020-06-17" version="1">RANLCCQGLGNETERSIISVLSPFILTFQLTWGTQVERFTHTGRVVLMPRIGYTIIAIIMAISCTLSVILNTTVIAVTIKYRQLRQPINYSLVNLAIADLGAALLGGTLNVETNAVGYYNLGRVGCVTEGFSMAFFGIVALCTIAVIAIDRAIVIGKPMGTLTFTTRKAMIGVAASWVWSLVWNTPPLFGWGGYQMEGVMTSCAPDWYNSDPINVSYIVCYFLFCFTIPFAAILVAKVGVAQRGSTTKAEAQVSRMVIVMVMAFLICWLPYATFALVVVGNPQIYINPIIATIPMYLAKSSTFYNPIIYIFMNNMNCLITKPIEYNGLKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I4F3</accession>
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        <submittedName>
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        <name evidence="8" type="primary">HHAT</name>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
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            <taxon>Unidentata</taxon>
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            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
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    <comment type="similarity">
        <text evidence="6">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
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        <property type="entry name" value="MBOAT"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006803.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="519" mass="60907" checksum="D6488B907A3031B6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I578</accession>
    <name>A0A670I578_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Angiopoietin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ANGPT4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Initiates complement activation and/or interferes in platelet aggregation and/or blood coagulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ficolin lectin family. Veficolin subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028735525.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000006867.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="pmua:114599801"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:fibrinogen complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:extracellular matrix structural constituent"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein-macromolecule adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:blood coagulation, common pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="angiopoietin-2 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANG-1/2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25443">
        <property type="entry name" value="ANG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1216">Complement system impairing toxin</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="12" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025634858" evidence="14">
        <location>
            <begin position="23"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="15">
        <location>
            <begin position="282"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="179"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="508" mass="57602" checksum="77D7167876E794C9" modified="2020-06-17" version="1">MWTVANLNVGALGLLVVAASWAVGSQRRAAEGGIRRRSHRVQNGRCSYTFVLPEADPQPCQHPGETFNVNTLQRDSPAGPLLWSDDQSTQRVQQLERVLENNTQWLLKLESYIQMNMKSEMVQIQQNVVQNQTATMLEIGTNLLNQTAEQTRKLTDVEAQVLNQTSRIEIQLLENSLSTNKLEKQLLMQTNEIHKLQNRNSILETRVLQMETKHLMELEGIRTEKEELQQLVIRQSDTIEVLEKSLHAASGNTSLLQQQQLQLLESVQNLVQLVSQGKVPPKKEDRLFQDCAEIRQSGINLSGVYTLHINNLTEPKKTYCDMETDGGGWTVIQYRVNGSVSFQKNWKEYKQGFGDPAGEYWLGNEAVHLLTNQGAYSLRVELLDWEGNRAYAHYEKLQLGSERQRYRLFLRGYKGSAGQQSGLPLQGTGFSTRDADNDNCRNCKCAQMLSGGWWFDACGLSNLNGIYYPAKHNIRKLNGIRWHYFQGPGYSLKGTRMMIRPSGSPEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5F0</accession>
    <name>A0A670I5F0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette sub-family G member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114596996</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028584786.1">
        <property type="nucleotide sequence ID" value="XM_028728953.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028584787.1">
        <property type="nucleotide sequence ID" value="XM_028728954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I5F0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007432.1">
        <property type="protein sequence ID" value="ENSPMRP00000006946.1"/>
        <property type="gene ID" value="ENSPMRG00000004737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596996"/>
    <dbReference type="KEGG" id="pmua:114596996"/>
    <dbReference type="GeneTree" id="ENSGT00940000162658"/>
    <dbReference type="OMA" id="FLTQLYW"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008514">
        <property type="term" value="F:organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000622">
        <property type="entry name" value="ATP-binding cassette sub-family G member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF82">
        <property type="entry name" value="ATP BINDING CASSETTE SUBFAMILY G MEMBER 2 (JUNIOR BLOOD GROUP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="66"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="705" mass="78305" checksum="7F472EF3442D81BB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I699</accession>
    <name>A0A670I699_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TRIM54</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
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        <subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19833">
        <property type="entry name" value="Bbox2_MuRF3_C-II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tripartite motif containing 55"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COS_domain"/>
    </dbReference>
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        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
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        <property type="entry name" value="Trim54_Bbox2_Zfn"/>
    </dbReference>
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        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TRIPARTITE MOTIF CONTAINING 55"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <location>
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            <dbReference type="PROSITE" id="PS51262"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007228.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
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    <sequence length="340" mass="38511" checksum="96AC9486F4B56C0C" modified="2020-06-17" version="1">AGSFKNTVPPSRPLASPSPCALHLSQHQGLFQGASNPLWQSRGSTSVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHAKAEQQLMCEEHEDEKINIYCLTCEVPTCSMCKVFGAHKDCEVAPLTNIYKRQKGELSDGIAMLVAGNDRIQAIITQMEEICKTIEDNARRQKQHLCLRFDSLYSILEERKKELLLEIGREQDDKLQRVRGLIRQYGDHLEVSSKLVESAIQSMEEPQMAAYLQQAKELIKKITDMSKVSMSSHPEPGYESMDHFTVNIDHVAEMLRTIEFQTGETHTWTRRGWEEGKATGHLLPWAELRIAGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6B5</accession>
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        <submittedName>
            <fullName evidence="1">Transmembrane protein 141</fullName>
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        <name evidence="1" type="primary">TMEM141</name>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="111" mass="12493" checksum="9298833CC7FF0A28" modified="2020-06-17" version="1">MVNVGLSRVDEAVAAKHPGLQEYTACQSYAFMKGMGTFITVSGMAFALQKFIRKIHYPLQWNILLSFVAGSVASYTVTRWETQRCSDLWIFLENKQPNKATVLAVNVQFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I842</accession>
    <name>A0A670I842_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-lactate dehydrogenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LDHA</name>
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    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A670I842"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008382.1">
        <property type="protein sequence ID" value="ENSPMRP00000007834.1"/>
        <property type="gene ID" value="ENSPMRG00000005300.1"/>
    </dbReference>
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        <property type="reaction ID" value="UER00611"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990204">
        <property type="term" value="C:oxidoreductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035686">
        <property type="term" value="C:sperm fibrous sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019661">
        <property type="term" value="P:glucose catabolic process to lactate via pyruvate"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042867">
        <property type="term" value="P:pyruvate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000029">
        <property type="entry name" value="L-lactate dehydrogenase A chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000003">
        <property type="entry name" value="L-lactate dehydrogenase A chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF10">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE A CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="181"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="349" mass="38754" checksum="C3DD8D57C48AA780" modified="2020-06-17" version="1">MKNELIVFLCFLPQSYKMSLKEKLIENVHKEEHPHAHNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMLDLQHGSLFLRTPKIVSGKDYAVTAHSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPSIVKYSPDCKLLVVSNPVDILTYVAWKISGFPKHRVIGSGCNLDSARFRHLMGERLGIHPLSCHGWIVGEHGDSSVPVWSGVNVAGVSLKTLHPDMGSDSDKENWKEVHKHVVESAYEVIKLKGYTSWAIGLSVADLAETLMKNLRRVHPVSTMVKGMHGIKDDVFLSVPCVLGYSGITDVVKMTLKSEEEDKLRKSADTLWGIQKELQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IAC2</accession>
    <name>A0A670IAC2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phospholysine phosphohistidine inorganic pyrophosphate phosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LHPP</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670IAC2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009422.1">
        <property type="protein sequence ID" value="ENSPMRP00000008820.1"/>
        <property type="gene ID" value="ENSPMRG00000005937.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159002"/>
    <dbReference type="OMA" id="REARCHC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07509">
        <property type="entry name" value="HAD_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000051">
        <property type="entry name" value="Phospholysine phosphohistidine inorganic pyrophosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006355">
        <property type="entry name" value="LHPP/HDHD2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01458">
        <property type="entry name" value="HAD-SF-IIA-hyp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF44">
        <property type="entry name" value="PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="349" mass="37984" checksum="4D43DAE6DD34BACF" modified="2020-06-17" version="1">MVPGSADQRRSTRKQVGGAHSSSNCLQALRRRSQPPRWRATTFPRRLGGQEGFGRRRRRRMCALVVGRLHGLLWAMAEWGKHLAGLEGLVLDISGVLYDSGGEGGGVPIPGSIEAVKKIKTSGLKLRFCTNETQATRDKFVGKLQHLGFDIGVDEVTAPAPAACRILKERNLRPHLLVHDDLIPEFADIDRANPNCVVVGDAADNFSYKNLNAAFQVLIGLENPVLISLGRGRYYKETDGLKLDVGAYMKALEYACDIQAEVVGKPAKMFFQSALTEMGIEPHQAIMIGDDIVNDVGGAQHCGMRALQVRTGKYRSLPPSAPADPPTLPSRYDGHVGGYRGRAESCCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IB20</accession>
    <name>A0A670IB20_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myomesin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Myomesin family member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MYOM1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028593102.1">
        <property type="nucleotide sequence ID" value="XM_028737269.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000009706.1">
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    <sequence length="1571" mass="176492" checksum="256FC7606418AA57" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBA1</accession>
    <name>A0A670IBA1_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114600816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="385" mass="42361" checksum="85EB224B8328F8D1" modified="2020-06-17" version="1">MLRVKAFSLAQSVQLAAAWVKVSSKHWSQWAKTNITCVQSYRTEQNSTGGAAYQAKGMGEKELPGVLICEIGGAFGVLESHVEFLKKHFNLITLREFHRNKDELREKIKSIFVFECRPLIDRELLESLPSLKVVANSGVGVNHLDLKLISSFGVKVTNTPHAVADSTADIGMALMLASARRLVEGCHIATSPDTTHFAVDWLGVEVTRATLGIIGMGSIGYKVAKRAKAFDMNILYHNRNRRKEEEEQAVGATYCRNIEDLLQGSDFVMLVVNLTPETHKLIGKRELQLMKPTATLINICRGAVVDQDALVEALKNGVIKAAALDVTHPEPLPRDHPLLQLKNVIITPHIGTATVQALLMMTEEAVENIQAVLNDLPIPSEVIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IC72</accession>
    <name>A0A670IC72_PODMU</name>
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        <submittedName>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IC72"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of membrane potential"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0048167">
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    </dbReference>
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        <property type="entry name" value="C2A_RIM1alpha"/>
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    </dbReference>
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        <property type="entry name" value="PDZ_RIM-like"/>
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        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 1, putative"/>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
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        <location>
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        <source>
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        </source>
    </evidence>
    <sequence length="1012" mass="114460" checksum="3BE442F38E8D600E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ID75</accession>
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        <recommendedName>
            <fullName evidence="6">Cytokine receptor-like factor 3</fullName>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="4">May play a role in the negative regulation of cell cycle progression.</text>
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        <text evidence="5">Belongs to the cytokine receptor-like factor 3 family.</text>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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        <location>
            <begin position="175"/>
            <end position="268"/>
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        <location>
            <begin position="7"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009628.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="437" mass="48710" checksum="3D9351FD8D494F55" modified="2020-06-17" version="1">METEALLLEARESVEAARTYRRELQQRLKGLQLARQQIKESAALTRDVLEQHFNDLKGTLRKLLDERLVSLLQEVDAIEEESIKPLDECRKLIEQGVGTADELLREGETVIHGVTGEESDKLCSFTKKALHIQLDSLPEVPSLVDVPCLSAQLDDSLLTVVRNQIFNHGAVASRPPIQIEELIEKPGGIIVKWCKVDEDFVPQDYRLQYRKITASHFEDVYVGSDTEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVSQTGCSTLVPHEWTPGFEGYSLSSRRNIALRNDSQVGGVLYSRAPTYYCGQTLTFRIETVGQPDKKDSIGVCVAQQNGADSLQRDKAVCVSTNGAVFVNGKEMTNQLPAVTSGSAVTFDIEAVNLGPSNNNNEGGNFKLRVTIGSNNREVVFDWVLDQSCGSLYFGCSFSYPGWKVLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IE99</accession>
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    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010071.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38228" checksum="B6A27B3401972F65" modified="2020-06-17" version="1">QGICLRRYCCDSNNNDLLSTWHSNTYVKLISQIARQTTTNECWICANAPSHLHSGIPFLGVPLTLEQHLSADVRSWNLTAVNLTHQYIYLTGPTTGDLCRKFSGNDKVIGESTCKYTLDITLSGRITLWHQGNPSTHLTLLSAWKRVMNLPDSWDPSPISQCFFRTFHTGRIDSCLQGLFWICGHRGYTWASPHSRGTCYLGLILPGVRVTQELPPGKRRNKRAKDLSELSDVAANGETYGRALFPAYGAGSNHVDILKLTDILLNFMEESNAATQSILTELTEVRQNSIQNRLALDYVLASTGGVCALIGTECCTHGEGGSGQVSGHSGYLRSPSPTPPIFNIIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IG76</accession>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="137"/>
            <end position="411"/>
        </location>
    </feature>
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        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010731.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="611" mass="67523" checksum="1C92230786839EC4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGC1</accession>
    <name>A0A670IGC1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial genome maintenance exonuclease 1</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">MGME1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGME1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
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        <property type="nucleotide sequence ID" value="XM_028738131.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593965.1">
        <property type="nucleotide sequence ID" value="XM_028738132.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593966.1">
        <property type="nucleotide sequence ID" value="XM_028738133.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000010729.1"/>
        <property type="gene ID" value="ENSPMRG00000007128.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114601085"/>
    <dbReference type="CTD" id="92667"/>
    <dbReference type="GeneTree" id="ENSGT00390000003349"/>
    <dbReference type="OMA" id="DCVAKYQ"/>
    <dbReference type="OrthoDB" id="5777131at2759"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000005">
        <property type="entry name" value="Mitochondrial genome maintenance exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03030">
        <property type="entry name" value="MGME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340:SF3">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="341" mass="39458" checksum="17DA5A1059CBF23B" modified="2020-06-17" version="1">MMSFLCINRKCWRVPMLLRGMLNQEGFRFRSLAASCSLYGKKKTTIRYENIDQEKYRDLINYLTSYKDSSQRPELVFEEDNMLNGPERKYKNSDQEDEPKVCRNWSPLMNPNKSSLPQETVPGPPLQISLQRKNLASVTAVLQQTMPVEQAFYLEKWKQRMILELGIEGFAEYTKNIFQQGKLFHAAMETLLLAEEISVEQEEDTNVSGYIRSVQHVLQHVTGVRVLESAVQHETLHYQGLVDCVAEYRGKLCAIEWKTSGKAKPFLRNTFDNPLQVAAYIGAINHDANYNFQVDCGLLVVAYKDGSPAHAHYIDSELCCQYWNKWLLRLEEYKEKDFGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IH43</accession>
    <name>A0A670IH43_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sarcoglycan delta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sarcoglycan beta/delta/gamma/zeta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IH43"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012167.1">
        <property type="protein sequence ID" value="ENSPMRP00000011395.1"/>
        <property type="gene ID" value="ENSPMRG00000007624.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158509"/>
    <dbReference type="OMA" id="MNFTIVI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048738">
        <property type="term" value="P:cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060047">
        <property type="term" value="P:heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006875">
        <property type="entry name" value="Sarcoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039972">
        <property type="entry name" value="Sarcoglycan_gamma/delta/zeta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939:SF6">
        <property type="entry name" value="DELTA-SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939">
        <property type="entry name" value="SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04790">
        <property type="entry name" value="Sarcoglycan_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8989" checksum="C510B1BD1F026F57" modified="2020-06-17" version="1">MPQEQYTHRSTMQSSEGPHVYKVGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTIVIVQKPARCCGDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IJ10</accession>
    <name>A0A670IJ10_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase Midline-1</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RING finger protein Midline-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RING-type E3 ubiquitin transferase Midline-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Tripartite motif-containing protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">MID1</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.</text>
    </comment>
    <comment type="function">
        <text evidence="23">Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ohanin/vespryn family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028583536.1">
        <property type="nucleotide sequence ID" value="XM_028727703.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583537.1">
        <property type="nucleotide sequence ID" value="XM_028727704.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583538.1">
        <property type="nucleotide sequence ID" value="XM_028727705.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583539.1">
        <property type="nucleotide sequence ID" value="XM_028727706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IJ10"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012074.1">
        <property type="protein sequence ID" value="ENSPMRP00000011302.1"/>
        <property type="gene ID" value="ENSPMRG00000007562.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596297"/>
    <dbReference type="KEGG" id="pmua:114596297"/>
    <dbReference type="CTD" id="4281"/>
    <dbReference type="GeneTree" id="ENSGT00940000155821"/>
    <dbReference type="OMA" id="FCDQEPA"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19836">
        <property type="entry name" value="Bbox1_MID1_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19822">
        <property type="entry name" value="Bbox2_MID1_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16753">
        <property type="entry name" value="RING-HC_MID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12892">
        <property type="entry name" value="SPRY_PRY_TRIM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase Midline-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000334">
        <property type="entry name" value="E3 ubiquitin-protein ligase Midline-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000153">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase MID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000014">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase MID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.40:FF:000002">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase MID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Afonso S."/>
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                <person name="Rubin C.J."/>
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                <person name="Sabatino S.J."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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        </source>
    </evidence>
    <sequence length="383" mass="41472" checksum="428A29BD906C1E77" modified="2020-06-17" version="1">MEPGRFLIFMFAAGAVHSAKTSLEIIPGNGDVQLAEKAYFLCKVRAGGEATLTWTDPEDTDIEDSELYTLRHIDEQSKGLEMTLPDPQAGGIFTCKGDFESGDTATAQIKIRVVQRPKFVTPMEPTKEVVEGTSVAFDCQATGIPPPTIRWTFGNQEISKIGDGGRVSMLANGTLVVKDSQPSDAGVHTCEASIKERNETVVMDVSLNIKFTPRIELLTGDSFATPIGTPAQYNFSILAYPPPSVSIAWKGKVFKGDDIKKVAQDQDRHTYSFEFTPASQEDLSELLITAANDQGSSKKKVTLQGDTQGLGTGILVLIVLIILLVALLVMDVFCYYKRQRGLLMYCRNNILGKNSSGTGTENNGKMLSKSGKSTVVNVSGIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKT5</accession>
    <name>A0A670IKT5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IKT5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013115.1">
        <property type="protein sequence ID" value="ENSPMRP00000012286.1"/>
        <property type="gene ID" value="ENSPMRG00000008212.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154386"/>
    <dbReference type="OMA" id="CIKICEI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001851">
        <property type="term" value="F:complement component C3b binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006956">
        <property type="term" value="P:complement activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000054">
        <property type="entry name" value="Complement inhibitory factor H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051503">
        <property type="entry name" value="ComplSys_Reg/VirEntry_Med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785:SF7">
        <property type="entry name" value="COMPLEMENT FACTOR H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="242"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="302"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="363"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="478"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="304"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="621" mass="69746" checksum="47379D556A6C0C57" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKY5</accession>
    <name>A0A670IKY5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitotic spindle organizing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MZT1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IKY5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013171.1">
        <property type="protein sequence ID" value="ENSPMRP00000012341.1"/>
        <property type="gene ID" value="ENSPMRG00000008255.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005954"/>
    <dbReference type="OMA" id="STNERYV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="84" mass="9605" checksum="1F1171F289C9AE46" modified="2020-06-17" version="1">MANPAANLNAVRETMEVLLEISRILNTGLDMETLSICVRLCEQGINPEALSAVIKELRKATEALKRRWRCVQAARAVFQYRWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IL77</accession>
    <name>A0A670IL77_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IL77"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013673.1">
        <property type="protein sequence ID" value="ENSPMRP00000012803.1"/>
        <property type="gene ID" value="ENSPMRG00000008563.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166838"/>
    <dbReference type="OMA" id="WIFSANG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="344"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="892"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1122"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1192"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135654" checksum="A5A60874B03099C1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INZ4</accession>
    <name>A0A670INZ4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">nucleoside diphosphate phosphatase</fullName>
            <ecNumber evidence="15">3.6.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Guanosine-diphosphatase ENTPD5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Uridine-diphosphatase ENTPD5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ENTPD5</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ADP + H2O = AMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:61437"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>CDP + H2O = CMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64880"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="3.6.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:64881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>GDP + H2O = GMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22156"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:22157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>IDP + H2O = IMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35207"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="EC" id="3.6.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:35208"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>UDP + H2O = UMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64876"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="3.6.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:64877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36799"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.6.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:36800"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Monomer; active form. Homodimer; disulfide-linked. Homodimers are enzymatically inactive.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 28">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.6" evidence="15"/>
    <dbReference type="RefSeq" id="XP_028575867.1">
        <property type="nucleotide sequence ID" value="XM_028720034.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575870.1">
        <property type="nucleotide sequence ID" value="XM_028720037.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575875.1">
        <property type="nucleotide sequence ID" value="XM_028720042.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575884.1">
        <property type="nucleotide sequence ID" value="XM_028720051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670INZ4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013852.1">
        <property type="protein sequence ID" value="ENSPMRP00000012972.1"/>
        <property type="gene ID" value="ENSPMRG00000008631.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114592126"/>
    <dbReference type="KEGG" id="pmua:114592126"/>
    <dbReference type="CTD" id="957"/>
    <dbReference type="GeneTree" id="ENSGT01150000286963"/>
    <dbReference type="OMA" id="WTCRIKE"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043262">
        <property type="term" value="F:ADP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036384">
        <property type="term" value="F:CDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990003">
        <property type="term" value="F:IDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051084">
        <property type="term" value="P:'de novo' post-translational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd24114">
        <property type="entry name" value="ASKHA_NBD_NTPDase5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000004">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000052">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF35">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE PHOSPHATASE ENTPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="27" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 29" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
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            <end position="19"/>
        </location>
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        <location>
            <begin position="20"/>
            <end position="428"/>
        </location>
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        <location>
            <position position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
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        </source>
    </evidence>
    <sequence length="428" mass="47421" checksum="6DCDDED4A28C52B8" modified="2020-06-17" version="1">MVLSWAAVIAMFALSSIYCLVSHHGPELWFQDLFPSKVCPANTGMDTLYGIMFDAGSTGTRIHIYTFVQRSPEKPAELEGEIFESVKPGLSAYADQPGKGAETVRQLLDMAKEAVPPSHWNKTPVVLKATAGLRLLAEHKAQALLSEVRAVFEESPFLVPDNSVSIMDGSYEGILAWITVNFLTGQLYGRNQQTVGTLDLGGASTQITFLPQREETLEQTPIDFLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALEMEASDGRTFRSSCLPKQLEAEWHFGGVKYQYGGNKEGETGFEPCYSEVLKVVKGKLHQPDEIRHSSFYAFSYYYDRAVDTALIDYEKGGVLKVEDFRRKAKEVCDNLDSYSSASPFLCMDLSYITALLKEGFGFGDSTVLQLAKKVNNIETSWALGATFHLLQSLGLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IPC8</accession>
    <name>A0A670IPC8_PODMU</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GPATCH3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="ENSPMRG00000009368.1"/>
    </dbReference>
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    </dbReference>
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    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="269"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="500" mass="57144" checksum="B637D6823A038F4A" modified="2020-06-17" version="1">MRFRCYKMAVPTTDNPSLQPSGRYCLISCVPAQLRSTDLRFYFSQFIEAGGFLCFHYRHRPERIEGPSAPSRPGPTCCCLVAVKPGWSRRLVRMYSGKRWIDAQGETLPGRCLIRRVRVSFDKDAETLSYKTKKELRTSSNETFTEDDLKRLPELNPPSFMPCGNVGTPLSVFLDLIKACRMPSRAIKKLRLQFPRTGSSRRYGNVPFSYEETKTIVEEERVYTASGEEITEGGDLSRVSTANQGNGMAERYLNDPESEAEAQLDDDDDDRCEEWERHEALHEDVTSQERTKERLFEEEIELKWEKGGSGLVFYTDAQYWQEEEEGDFDEQTADDWDVDMSIYYDKDGGDKDARDLVQMRFEQRLRDGLEDGSVLSQQIGNFEKYTKGIGRKVMERQGWTEGLGLGSSNSGMTEALDNEGQNPKCKRGLGYHGEKLQTFTKPKKPRGDNSILISTIYDDPYPVDAEEQLLRRQLPISMKHRQDVAFGHAMHGVHHNSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQN0</accession>
    <name>A0A670IQN0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Neuropeptide FF receptor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">G-protein coupled receptor 74</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NPFFR2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028600254.1">
        <property type="nucleotide sequence ID" value="XM_028744421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IQN0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015272.1">
        <property type="protein sequence ID" value="ENSPMRP00000014300.1"/>
        <property type="gene ID" value="ENSPMRG00000009530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604370"/>
    <dbReference type="KEGG" id="pmua:114604370"/>
    <dbReference type="CTD" id="10886"/>
    <dbReference type="GeneTree" id="ENSGT01150000286926"/>
    <dbReference type="OMA" id="TRPVYWC"/>
    <dbReference type="OrthoDB" id="5953793at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031628">
        <property type="term" value="F:opioid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000137">
        <property type="entry name" value="neuropeptide FF receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005395">
        <property type="entry name" value="NPFF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005397">
        <property type="entry name" value="NPFF_rcpt_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF132">
        <property type="entry name" value="NEUROPEPTIDE FF RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01570">
        <property type="entry name" value="NPFFRECEPTOR"/>
    </dbReference>
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        <property type="entry name" value="NPFFRECEPTR2"/>
    </dbReference>
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        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="62"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSPMRP00000014300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="424" mass="47965" checksum="A48481AF9461B790" modified="2020-06-17" version="1">MDKNLDSSPSVSRPPVRNCSGHISSCNMETNISYVGFYLHQPLVAAVFIISYLLIFLLCMIGNGVVCFIVLRSKHMRTVTNLFILNLAVSDLLVGIFCMPTTLVDNIISGWPFGNIACKMNGMVQGISVSASVFTLVAIAVDRFRSIVYPFKQKLTIWTAVVIIVVIWVLAIAIMCPSAVMLKVEESRHFRVLLGYDNRTSPIYWCREDWPNQDMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFNTSLPASGKQGQERHSVCRKKLKVIKMLIIVALLFILSWLPLWTLAMLSDYADLNEEQLQVINIYIYPFAHWLAFFNSSINPIIYGFFNENFRRGFQAVFRLQLCSGDGMPRETYSQRGQSNAILPAADPQEPEHSLTSAMMGKSTQKGNWMDKTQVLMMENLEQVSNNHGVKQDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQP0</accession>
    <name>A0A670IQP0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IQP0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015283.1">
        <property type="protein sequence ID" value="ENSPMRP00000014310.1"/>
        <property type="gene ID" value="ENSPMRG00000009539.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025336978" description="Reverse transcriptase domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="307" mass="35495" checksum="03FAB5E038CD1309" modified="2020-06-17" version="1">SHGRPFHCHTGTRQGCPLSPLLFILVLEVLLNAIRQNSEIKGITIGQNEYKVKAFADDVVITLEEPKNSSKEVLEEIEQFGKVAGFKLNKRKTKIIVKNMDTRATEELQQQTEIEVTKKVKYLGVWVTPRNIDLLKNNYEPVWKGIKKDLEVWGKLQMSFWGRIAIIKMNVLPRMLFLFQNIPVIKGTKIFKEWQRGISKFIWQGKKPRIKFKLLTDVKERGGFALPDLKLYYEASCLCWLKLWIKLENTEMLDLEVRNNGSKSSVSPTMETEGIANNRGVEIQIVGLRGARQNDRENQIHKRPKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQZ6</accession>
    <name>A0A670IQZ6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Yes1 associated transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">YAP1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the YAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028581977.1">
        <property type="nucleotide sequence ID" value="XM_028726144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IQZ6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015096.1">
        <property type="protein sequence ID" value="ENSPMRP00000014131.1"/>
        <property type="gene ID" value="ENSPMRG00000009439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595658"/>
    <dbReference type="CTD" id="10413"/>
    <dbReference type="GeneTree" id="ENSGT00510000046760"/>
    <dbReference type="OMA" id="IIHPRAN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001674">
        <property type="term" value="C:female germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140552">
        <property type="term" value="C:TEAD-YAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070064">
        <property type="term" value="F:proline-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060449">
        <property type="term" value="P:bud elongation involved in lung branching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061026">
        <property type="term" value="P:cardiac muscle tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071480">
        <property type="term" value="P:cellular response to gamma radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003143">
        <property type="term" value="P:embryonic heart tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903703">
        <property type="term" value="P:enterocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097191">
        <property type="term" value="P:extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <sequence length="505" mass="54560" checksum="C33CE4238D7A1328" modified="2020-06-17" version="1">MDAAGQPPQSASQQPGQQQQPPPPPNSSGQPPPQAPPPQQPGGGAAVSGPPPAGHQIVHVRGDSETDLEALFNAVMNPKGANVPHTLPMRLRKLPDSFFKPPEPKAHSRQASTDAGTAGALTPQHVRAHSSPASLQLGTVSPGGLTPSGIVPGAAPSSQHLRQSSFEIPDDVPLPPGWEMAKTPSGQRYFLNHIDQTTTWQDPRKALLSQMNVTAPTSPPVQQSIMNSATGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMSQRISQSAPVKQPPPIAPQSPPGGVLGGSNSNQQQQMRLQQLQMEKERLRLKHQELLRQALRNINPSTANSPKRQELALRSQLPSMEQDGVPQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSNIPSHQNRFPDYLEAIPGTNVDLGTLEGDAMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITZ6</accession>
    <name>A0A670ITZ6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANKH inorganic pyrophosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ANKH</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ANKH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028593788.1">
        <property type="nucleotide sequence ID" value="XM_028737955.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000016284.1">
        <property type="protein sequence ID" value="ENSPMRP00000015241.1"/>
        <property type="gene ID" value="ENSPMRG00000010162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601016"/>
    <dbReference type="KEGG" id="pmua:114601016"/>
    <dbReference type="CTD" id="56172"/>
    <dbReference type="GeneTree" id="ENSGT00390000012189"/>
    <dbReference type="OMA" id="FYQGILI"/>
    <dbReference type="OrthoDB" id="10055429at2759"/>
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        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030504">
        <property type="term" value="F:inorganic diphosphate transmembrane transporter activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009887">
        <property type="entry name" value="ANKH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28384">
        <property type="entry name" value="PROGRESSIVE ANKYLOSIS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28384:SF1">
        <property type="entry name" value="PROGRESSIVE ANKYLOSIS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07260">
        <property type="entry name" value="ANKH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="492" mass="54253" checksum="FA9763BBE7DB378B" modified="2020-06-17" version="1">MVKFPALTNYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRTKAVLCMVVAGAVAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRKAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYRNIHDIIPDSSGPEMGGDATIKKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLVNTSSTVTATHIKKFTFVCMALSLTLCFVMFWTPNVSEKILVDIIGVDFAFAELCVIPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLITSLIVLPYLGVHGATLGVGSLLAGFVGESTMVAIAACYVYQKQKKKRNDNETATEGEDSAMTDMPHTEEMTDIVEMRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IV09</accession>
    <name>A0A670IV09_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IV09"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016828.1">
        <property type="protein sequence ID" value="ENSPMRP00000015760.1"/>
        <property type="gene ID" value="ENSPMRG00000010525.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012138"/>
    <dbReference type="OMA" id="MIANNCP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="109" mass="12153" checksum="8C5F8D433F3FFF13" modified="2020-06-17" version="1">MVAAKKTKKSPESINSRLQLVMKSGKHVLGYKQTLKMIRQGKAELVILANNCPALRKSETEYYGMLAKTGVHHYNTELGTACGKYYRVCTLDPGDSDISRSMPEQTSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVJ9</accession>
    <name>A0A670IVJ9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 189-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114599632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591019.1">
        <property type="nucleotide sequence ID" value="XM_028735186.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028591020.1">
        <property type="nucleotide sequence ID" value="XM_028735187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IVJ9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016850.1">
        <property type="protein sequence ID" value="ENSPMRP00000015781.1"/>
        <property type="gene ID" value="ENSPMRG00000010541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599632"/>
    <dbReference type="KEGG" id="pmua:114599632"/>
    <dbReference type="GeneTree" id="ENSGT00940000163703"/>
    <dbReference type="OMA" id="KFVWTCY"/>
    <dbReference type="OrthoDB" id="5103at2759"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050207">
        <property type="term" value="F:plasmanylethanolamine desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052601">
        <property type="entry name" value="Plasmalogen_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177:SF1">
        <property type="entry name" value="PLASMANYLETHANOLAMINE DESATURASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid desaturase" evidence="8">
        <location>
            <begin position="146"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="332" mass="36900" checksum="BC3A4CB1F4BFDA3D" modified="2020-06-17" version="1">MLLPPPPSSLLPGGAPGAGARAMAGPELQDEAGLREQQDEGGERGRGGATAECARGRAAGASRAVSEAEAAAPAAQGDPDGACPRWGAQHAGARELAELYSPGKRLQEWISVILCFSLMSFNFYHLLFCLRLEHAFSIIFGIFAGIITADFASGLVHWGADTWGSVDLPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCMLTVVPLANMAYKLVSLSPEALHQSCPWECYVFALAIFGTLTNQIHKWSHTYFGLPRWVIFLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEKIRFWRFLEIIIQGLTGEKPRADDMKWAQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVS7</accession>
    <name>A0A670IVS7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GDNF family receptor alpha 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GFRA4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDNFR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028600080.1">
        <property type="nucleotide sequence ID" value="XM_028744247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IVS7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016669.1">
        <property type="protein sequence ID" value="ENSPMRP00000015609.1"/>
        <property type="gene ID" value="ENSPMRG00000010413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604272"/>
    <dbReference type="KEGG" id="pmua:114604272"/>
    <dbReference type="CTD" id="64096"/>
    <dbReference type="GeneTree" id="ENSGT00940000160491"/>
    <dbReference type="OMA" id="CQRENYA"/>
    <dbReference type="OrthoDB" id="10047040at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016167">
        <property type="term" value="F:glial cell-derived neurotrophic factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.110:FF:000001">
        <property type="entry name" value="GDNF family receptor alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.110">
        <property type="entry name" value="GDNF binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF2">
        <property type="entry name" value="GDNF FAMILY RECEPTOR ALPHA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01316">
        <property type="entry name" value="GDNFRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025431434" evidence="10">
        <location>
            <begin position="23"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="11">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="11">
        <location>
            <begin position="145"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="11">
        <location>
            <begin position="235"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="430" mass="47592" checksum="08F3E62F82FC78AA" modified="2020-06-17" version="1">MKGILYIFTLILTEGMTDVASSARDCLQAGESCTNDPSCSSKFRTLRQCIAGNGANKLGPDAKSQCQNTVTALLSSQLYGCKCKRGMKKEKHCLSVYWSIHHTLMEGMNVMESSPYEPFVRGFDYVRLASITAGSENEVTQVNRCLDAAKACNVDEVCQRLRTEYVSSCIRRTARADTCNRSKCHKALRKFFDRVPPEYTHELLFCPCDDTACAERRRQTIVPTCSYEAKERPNCLAPLDSCRVNYVCRSRYAEFQFNCQSSAQSATGCQRENYAACLLAYTGIIGSPITPNYIDNSTSNIAPWCTCNASGNRQEECENFLHLFTKNLCLQNAIQAFGNGTYLSAALGSSTPPTTQMRKQERNANKAAATLRENIFEQLQPTKVSAEEKLLQDATHLASDGSSSALSLAMNGWLVMWCSTSTSTFLLASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWD4</accession>
    <name>A0A670IWD4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosylmethionine sensor upstream of mTORC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Probable methyltransferase BMT2 homolog</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BMT2</name>
        <name evidence="4 6" type="synonym">SAMTOR</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028601327.1">
        <property type="nucleotide sequence ID" value="XM_028745494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IWD4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017373.1">
        <property type="protein sequence ID" value="ENSPMRP00000016275.1"/>
        <property type="gene ID" value="ENSPMRG00000010873.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604918"/>
    <dbReference type="KEGG" id="pmua:114604918"/>
    <dbReference type="CTD" id="475290"/>
    <dbReference type="GeneTree" id="ENSGT00390000010382"/>
    <dbReference type="OMA" id="CCQKAYE"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061431">
        <property type="term" value="P:cellular response to methionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000089">
        <property type="entry name" value="S-adenosylmethionine sensor upstream of mTORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="402" mass="46106" checksum="595791991F3FF400" modified="2020-06-17" version="1">MEPELGPPSGASASFPCPPPPPPREQERKLQQEKLSGVVKSVHRRLRKKYREVGDFEKIWREHCEDEETLCEYAEAMKNLADNHWTKTCEGEGRIEWCCSVSREYFQNGGKRKALEKDEKRAVLATQSIQTMSIHPASKIEDSSEKSNHSSIMDELLHPSGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQIQQPLQLAQDAIDAFLKQLKNPIDSLPGELFHIVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEEEEFSNNSCYIRSDAEDEQLAYSFMELPDAPYDSDSGESQTSSIPFYELEDPILLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWR8</accession>
    <name>A0A670IWR8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TTC1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the GAP domain of NF1. Interacts (via TPR repeats) with HSP90AA1 and HSPA8.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IWR8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017337.1">
        <property type="protein sequence ID" value="ENSPMRP00000016241.1"/>
        <property type="gene ID" value="ENSPMRG00000010829.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157213"/>
    <dbReference type="OMA" id="KSAIDDC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150078">
        <property type="term" value="P:positive regulation of neuroinflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000367">
        <property type="entry name" value="Tetratricopeptide repeat domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="279" mass="32183" checksum="4F0390FD02513372" modified="2020-06-17" version="1">LNMESEDSISPEKLVEGLKLSEEQSSPSQPDCNNVHVPKIAKEGVTQLPHSESREDEDLFHDCNDSFEADHLENEIELDEKDLLELEKNMSEEEKQKRRNESTKLKEEGNEQFKKGEYKEAEDAYARALQVCPACCNTDRSILYSNRAAARMKQEKREIAISDCSKALELNPNYIKALLRRAELYEKTEKLDEALEDYKNLLEKDPSIHQAREACMRLPRQIEERNEKLKEEMLGKLKDLGNLVLRPFGLSTENFQVKQDSSTGSYSINFVQNPNNNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IX71</accession>
    <name>A0A670IX71_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HECT domain E3 ubiquitin protein ligase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HECTD4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="Ensembl" id="ENSPMRT00000017846.1">
        <property type="protein sequence ID" value="ENSPMRP00000016743.1"/>
        <property type="gene ID" value="ENSPMRG00000010340.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144226"/>
    <dbReference type="OMA" id="HDYHLQE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13735">
        <property type="entry name" value="SPRY_HECT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000015">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HECTD4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000030">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HECTD4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043366">
        <property type="entry name" value="HECTD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035781">
        <property type="entry name" value="SPRY_HECTD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46435">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46435:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="4065"/>
            <end position="4438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1922"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2649"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3289"/>
            <end position="3342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3447"/>
            <end position="3466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3753"/>
            <end position="3831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1922"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2662"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3289"/>
            <end position="3316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="3317"/>
            <end position="3326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3330"/>
            <end position="3339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3754"/>
            <end position="3770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3798"/>
            <end position="3831"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="4406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="4438" mass="486907" checksum="AF0B0339365FB5B8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXA4</accession>
    <name>A0A670IXA4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IXA4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017700.1">
        <property type="protein sequence ID" value="ENSPMRP00000016600.1"/>
        <property type="gene ID" value="ENSPMRG00000011050.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="100" mass="10945" checksum="665053427C82F7A6" modified="2020-06-17" version="1">MGKGRSSVEGFNGASSPSGARGFFYLSPFLSLFSHSFVMVKGAALLLQEEEKLESVQEGPATPLDHKPKSENAAAEQQEQHLQQMVGLMRPEDSIRLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXY4</accession>
    <name>A0A670IXY4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="20">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PLCD3</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="18">Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A670IXY4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017392.1">
        <property type="protein sequence ID" value="ENSPMRP00000016294.1"/>
        <property type="gene ID" value="ENSPMRG00000010884.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156993"/>
    <dbReference type="OMA" id="LAVYCHA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16218">
        <property type="entry name" value="EFh_PI-PLCdelta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13363">
        <property type="entry name" value="PH_PLC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08593">
        <property type="entry name" value="PI-PLCc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000071">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000088">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000058">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000026">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028391">
        <property type="entry name" value="PLC-delta1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039504">
        <property type="entry name" value="PLC-delta3_EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF33">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14788">
        <property type="entry name" value="EF-hand_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 20" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="21">
        <location>
            <begin position="54"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="23">
        <location>
            <begin position="512"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="22">
        <location>
            <begin position="628"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="374"/>
        </location>
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</entry>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="476" mass="52311" checksum="023C27D1EBEBE68E" modified="2020-06-17" version="1">MGIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARSYPVGGLCYYLSPPESFTSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J067</accession>
    <name>A0A670J067_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="13">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">PIF1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A670J067"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018736.1">
        <property type="protein sequence ID" value="ENSPMRP00000017600.1"/>
        <property type="gene ID" value="ENSPMRG00000011617.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063561"/>
    <dbReference type="OMA" id="SSAWESC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033678">
        <property type="term" value="F:5'-3' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001117">
        <property type="term" value="P:protein-DNA-RNA complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000805">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003367">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="193"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="13">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="597" mass="66309" checksum="652A08E56EE848E0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J0H7</accession>
    <name>A0A670J0H7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integrator complex subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">INTS13</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Integrator subunit 13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J0H7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018849.1">
        <property type="protein sequence ID" value="ENSPMRP00000017705.1"/>
        <property type="gene ID" value="ENSPMRG00000011697.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002793"/>
    <dbReference type="OMA" id="NCTAMHR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160232">
        <property type="term" value="C:INTAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160240">
        <property type="term" value="P:RNA polymerase II transcription initiation surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019355">
        <property type="entry name" value="Cell_cycle_regulator_Mat89Bb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-95-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10221">
        <property type="entry name" value="Mat89Bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="644"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="644"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="786" mass="88495" checksum="51D79D744567ED23" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3M7</accession>
    <name>A0A670J3M7_PODMU</name>
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        <submittedName>
            <fullName evidence="5">Rho GTPase activating protein 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">ARHGAP1</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSPMRG00000012280.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160630"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:endosomal transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001136">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP-p50rhoGAP"/>
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    </dbReference>
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        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rho GTPase-activating protein 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Rho GTPase activation protein"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
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        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13716">
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    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="270"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="462" mass="53515" checksum="D0ED2A5B517CA781" modified="2020-06-17" version="1">MLQTESNQAVFAQEGEMDGVQPVVLENMEQYPDLQEDLSLEDTNESLNQLKLASLDDKNWPPDEVPVFPKSDDFKGSPDPVTHLRWDDPYYDIARHQIVEVAGDDKYGRKVILFSACRMPPSYQLDHVKLLSYLKYTLDQYVESDYTLVYLHHGLTSENKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYANYLSDLEEHVKLEQLGIPSQVLKYDEYLRSLQKPSQVPQKVTPPRPPLPNQQFGVSLQHLREKSLDQNPIPLVVRETVAYLQQHALNTEGIFRRSANTQTVREVQQKYNMGLPVDFVQYEDVHLPAVILKTFLRELPEPLLTYGLYNDVVSFYSVEEEKRVDIVRKTLQSLPEENYQVLCTLMSFLVQVSANSDINKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFSKFLLDNQRELFQSLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3Q6</accession>
    <name>A0A670J3Q6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="5 13">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IPPK</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IPK1 type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="5 13"/>
    <dbReference type="AlphaFoldDB" id="A0A670J3Q6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020008.1">
        <property type="protein sequence ID" value="ENSPMRP00000018835.1"/>
        <property type="gene ID" value="ENSPMRG00000012321.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010053"/>
    <dbReference type="OMA" id="HRQHCIV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901838">
        <property type="term" value="P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.110:FF:000001">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="503" mass="58233" checksum="7B41F9E8DDC4FD9B" modified="2020-06-17" version="1">MEAEKMDENEWRYHGEGNKSLVVSHRQRCVVLRFLKFPPNRDKTPEEIFQHLQNIVYFGKHIMKQFFGEKYVHHGEVVQLSLDFLKQLCLKIQSERPESRCDKDMDALSGYAMCLPNLTRLHVVEHRPILCVEIKPKCGFLPFSSHVSQEIKHKVCRYCMHQHLKVAKGKWKRQSKYCPLDLFSGNKQRMHFALRSLLQEAQNNLKIFKNGELIYGCKDNEDALSDLNELACHLKPFFFPSNGLVNGTHCTRTVLKELIHVITMALLSSTDACKAGDMKTVPSSQGRSFCEASAFSKEIARNGKNKMETSGLPKECLLYKTLQAQMLDMLDIEGVYPLYNRVEQYLEEFPKERNVLQIDGPYNESFYEKLLDISTEDDGTVAYALTKVQQYRVAMTAKDCSIMIALSPCQQDECAVQRPLVLTSKSRFTFSVSVLDLDLKPYESIHHQYKLDRKIVNFYLKNTQAKDDSVMSNLLKENEDCTLLLHKINTEYHSDYLEGMYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J693</accession>
    <name>A0A670J693_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114583312</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028560474.1">
        <property type="nucleotide sequence ID" value="XM_028704641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J693"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020930.1">
        <property type="protein sequence ID" value="ENSPMRP00000019700.1"/>
        <property type="gene ID" value="ENSPMRG00000012865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114583312"/>
    <dbReference type="KEGG" id="pmua:114583312"/>
    <dbReference type="GeneTree" id="ENSGT00940000162891"/>
    <dbReference type="OMA" id="LRYPHIM"/>
    <dbReference type="OrthoDB" id="9445499at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050939">
        <property type="entry name" value="Olfactory_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242:SF227">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="41"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="319" mass="36085" checksum="650D620893C7737B" modified="2020-06-17" version="1">MEMDNMTSVQEFILLGFGIGQHKRFLLLIFFTILYMLTLAENITIITLVFLDNHLAQLPMYILLSNFSWLEMCYVSTTVPRMLFDLASPHGVISFHECFLQFYIFFSLGCTECFFLSTMALDRYLAICCPLRYPHIMSPHFCYTLVALCWVVGFLWYLVPAVLISLLSFCGSNTIDHFLCDPGPILALACPPLGNAPLFSQICLNGLIIGNVSFVVLSYSTVILTLMKTSSQGNRRKAFSTISFHIVVVTLFYGSVAGMYLIPGGESQSEVTKAVTLFYTAITPFLNPLIYCLRNDQVKEAVGRLLRRKVRSLERKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J6P0</accession>
    <name>A0A670J6P0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TFDP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583893.1">
        <property type="nucleotide sequence ID" value="XM_028728060.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583894.1">
        <property type="nucleotide sequence ID" value="XM_028728061.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583895.1">
        <property type="nucleotide sequence ID" value="XM_028728062.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583897.1">
        <property type="nucleotide sequence ID" value="XM_028728064.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583898.1">
        <property type="nucleotide sequence ID" value="XM_028728065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J6P0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020119.1">
        <property type="protein sequence ID" value="ENSPMRP00000018942.1"/>
        <property type="gene ID" value="ENSPMRG00000012383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596447"/>
    <dbReference type="KEGG" id="pmua:114596447"/>
    <dbReference type="CTD" id="7027"/>
    <dbReference type="GeneTree" id="ENSGT00940000154652"/>
    <dbReference type="OMA" id="MSPNDAH"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035189">
        <property type="term" value="C:Rb-E2F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043276">
        <property type="term" value="P:anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008544">
        <property type="term" value="P:epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070345">
        <property type="term" value="P:negative regulation of fat cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900087">
        <property type="term" value="P:positive regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000278">
        <property type="term" value="P:regulation of DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000047">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.80:FF:000001">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009404">
        <property type="entry name" value="Transcription_factor_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="11">
        <location>
            <begin position="111"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="10">
        <location>
            <begin position="201"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="352"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="413" mass="45485" checksum="6D7FDF1201CB380D" modified="2020-06-17" version="1">MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSAVNTLGKQLLPKTFGQSNVNIAQQMVIGTPQRPSAPNTILVSSPHTPNTHFVPQNQTADSSPWSAGKRNKKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSTADAHISPNESQAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRQAEQQANRPPASNSVIHLPFIIVNTSKKTVIDCSISNDKFEYLFNFDNAFEIHDDIEVLKRMGMAFGLESGSCSAEDLKNARSLVPKALEPYVTEMAQGSISSVYVSSSSGSASNGTRFSNSDYSNGGDGMLATSSNGSQYSGSRVETPVSYVGDDDDDDDEDFNENDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8M9</accession>
    <name>A0A670J8M9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitofusin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MFN2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J8M9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022098.1">
        <property type="protein sequence ID" value="ENSPMRP00000020813.1"/>
        <property type="gene ID" value="ENSPMRG00000013518.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013727"/>
    <dbReference type="OMA" id="YRINCES"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048593">
        <property type="term" value="P:camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007006">
        <property type="term" value="P:mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="MITOFUSIN-2"/>
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        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_DYNAMIN_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="629"/>
            <end position="647"/>
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    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="93"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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        <source>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="721" mass="81715" checksum="14B5C8A0496475D6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC09</accession>
    <name>A0A670JC09_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 30">Platelet-derived growth factor receptor alpha</fullName>
            <shortName evidence="30">PDGF-R-alpha</shortName>
            <shortName evidence="30">PDGFR-alpha</shortName>
            <ecNumber evidence="4 30">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28 30">Alpha platelet-derived growth factor receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27 30">Alpha-type platelet-derived growth factor receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="43" type="primary">PDGFRA</name>
    </gene>
    <organism evidence="43 44">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="43 44" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="43" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="43" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="30">Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29 45">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="30">Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.</text>
    </comment>
    <comment type="subunit">
        <text evidence="30">Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 30">Cell membrane</location>
            <topology evidence="2 30">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="38">Membrane</location>
            <topology evidence="38">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="30 38">Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="4 30"/>
    <dbReference type="RefSeq" id="XP_028600208.1">
        <property type="nucleotide sequence ID" value="XM_028744375.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000020737.1"/>
        <property type="gene ID" value="ENSPMRG00000013463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604335"/>
    <dbReference type="CTD" id="5156"/>
    <dbReference type="GeneTree" id="ENSGT00940000156021"/>
    <dbReference type="OMA" id="PGLILCQ"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990270">
        <property type="term" value="C:platelet-derived growth factor receptor-ligand complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160185">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005018">
        <property type="term" value="F:platelet-derived growth factor alpha-receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048407">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005161">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048557">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033327">
        <property type="term" value="P:Leydig cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001553">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:male genitalia development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072277">
        <property type="term" value="P:metanephric glomerular capillary formation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010544">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042475">
        <property type="term" value="P:odontogenesis of dentin-containing tooth"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:platelet aggregation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038091">
        <property type="term" value="P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050921">
        <property type="term" value="P:positive regulation of chemotaxis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <alternativeName>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Lacertibaenia</taxon>
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    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028558155.1">
        <property type="nucleotide sequence ID" value="XM_028702322.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028558156.1">
        <property type="nucleotide sequence ID" value="XM_028702323.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028558157.1">
        <property type="nucleotide sequence ID" value="XM_028702324.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000022300.1">
        <property type="protein sequence ID" value="ENSPMRP00000021002.1"/>
        <property type="gene ID" value="ENSPMRG00000013655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114581770"/>
    <dbReference type="KEGG" id="pmua:114581770"/>
    <dbReference type="CTD" id="5198"/>
    <dbReference type="GeneTree" id="ENSGT00390000007600"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097294">
        <property type="term" value="P:'de novo' XMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000010">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
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    </dbReference>
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        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000014">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000007">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, putative"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000014">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, putative"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000001">
        <property type="entry name" value="Putative phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="80"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="182"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="442"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="674"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="859"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1337" mass="144829" checksum="046185EBB13C251A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JGR1</accession>
    <name>A0A670JGR1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING1 and YY1 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RYBP</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JGR1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025078.1">
        <property type="protein sequence ID" value="ENSPMRP00000023631.1"/>
        <property type="gene ID" value="ENSPMRG00000015294.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013995"/>
    <dbReference type="OMA" id="PEREHGP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000009">
        <property type="entry name" value="YY1 associated factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039958">
        <property type="entry name" value="RYBP/YAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033774">
        <property type="entry name" value="YAF2_RYBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920:SF3">
        <property type="entry name" value="RING1 AND YY1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920">
        <property type="entry name" value="RYBP AND YAF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17219">
        <property type="entry name" value="YAF2_RYBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025641364" evidence="10">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="11">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="268" mass="29119" checksum="28C6543F256449DA" modified="2020-06-17" version="1">SSYGGCFSLSLSLSLSLSLSLTHTHTHTHTHTHSSSSPHTDFFQTKGDLTRPKRQAKPAADEGFWDCSVCTFRNSAEAFKCSICDVRKGTSTRKPRINSQLVAQQVAQQYATPPPPKKEKKEKVEKQEEKKPDKEKEISQSVIKKSTSKKTKPKSDIVKDPPSEANSIQSGNMTTKASDSNHTSRPRLKNVDRSTAQQLAVTVGNVTVIITDFKEKTRSSSTSSSTVTSSAGSEQQNQSSSGSESTDKGSSRSSTPKGDMSVVNDESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHA8</accession>
    <name>A0A670JHA8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Synaptophysin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114603573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptophysin/synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598525.1">
        <property type="nucleotide sequence ID" value="XM_028742692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JHA8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024427.1">
        <property type="protein sequence ID" value="ENSPMRP00000022999.1"/>
        <property type="gene ID" value="ENSPMRG00000014933.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603573"/>
    <dbReference type="KEGG" id="pmua:114603573"/>
    <dbReference type="GeneTree" id="ENSGT01030000234637"/>
    <dbReference type="OMA" id="CHFNEIR"/>
    <dbReference type="OrthoDB" id="10006326at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001285">
        <property type="entry name" value="Synaptophysin/porin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306">
        <property type="entry name" value="SYNAPTOPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306:SF9">
        <property type="entry name" value="SYNAPTOPHYSIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00220">
        <property type="entry name" value="SYNAPTOPHYSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="10"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="237" mass="26067" checksum="95C0E604A0A8C2DC" modified="2020-06-17" version="1">MSGLQINLGPVKEPLGFIKVLEWIFAIFAFATCGGYSGKTSLILNCYNGTNASLQANFAYPFRLHQSSFDIPSSKQCHSIWNSTYYLVGDFASPAQFFVTFAVFVFLYCMAALVLYVGYLHLYRGTGKLPMIDFVITVVVSFLWLVSTSAWAKALTDIKTSTGHSITELQPCVSQTNRCQFNDIRSLGSLNVSVVIGFLNLILWAGNAWFVYKETNLHNPPAAAPPTPGNPPPHSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHW9</accession>
    <name>A0A670JHW9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tubulin polymerization-promoting protein family member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114582121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028558741.1">
        <property type="nucleotide sequence ID" value="XM_028702908.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028558742.1">
        <property type="nucleotide sequence ID" value="XM_028702909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JHW9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025760.1">
        <property type="protein sequence ID" value="ENSPMRP00000024288.1"/>
        <property type="gene ID" value="ENSPMRG00000015699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582121"/>
    <dbReference type="KEGG" id="pmua:114582121"/>
    <dbReference type="GeneTree" id="ENSGT00940000155965"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000188">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Salvi D."/>
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        <scope>IDENTIFICATION</scope>
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</entry>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Bifurcata</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_methyltr_RlmE"/>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="5">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="58" mass="6711" checksum="CF064033BA4E9611" modified="2020-06-17" version="1">MGKKPKVGKTRRDKFYHLAKETGFRSRSSFKLIQLNRKFQFLPKSRALLDLCAAPGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJX2</accession>
    <name>A0A670JJX2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase II subunit J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">POLR2J</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028564513.1">
        <property type="nucleotide sequence ID" value="XM_028708680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JJX2"/>
    <dbReference type="SMR" id="A0A670JJX2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026206.1">
        <property type="protein sequence ID" value="ENSPMRP00000024696.1"/>
        <property type="gene ID" value="ENSPMRG00000015961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585801"/>
    <dbReference type="KEGG" id="pmua:114585801"/>
    <dbReference type="CTD" id="5439"/>
    <dbReference type="GeneTree" id="ENSGT00550000074975"/>
    <dbReference type="OMA" id="MNAPSRY"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="117" mass="13293" checksum="6F78AB256EF8F647" modified="2020-06-17" version="1">MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKH4</accession>
    <name>A0A670JKH4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114582180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028558811.1">
        <property type="nucleotide sequence ID" value="XM_028702978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JKH4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025493.1">
        <property type="protein sequence ID" value="ENSPMRP00000024029.1"/>
        <property type="gene ID" value="ENSPMRG00000015551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582180"/>
    <dbReference type="KEGG" id="pmua:114582180"/>
    <dbReference type="GeneTree" id="ENSGT01150000286972"/>
    <dbReference type="OMA" id="CLDICYT"/>
    <dbReference type="OrthoDB" id="9975554at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="40"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="306" mass="34148" checksum="66BBC9C83BF2693C" modified="2020-06-17" version="1">MRVNKSMVNSFLLLGFSDLPGLEGLFFSIFLSIYVLTLIGNILIIAVTLANQALHSPMYFFLRNLSYLEICCTSVIIPKMLENLLSKDKTISFVGCAFQMCGFLITGAAECFLLAAMAYDRYVAICRPLHYTLIMSSRVCFGLVAASWLAAIPVQLGQTFLVFTSYFCDSKEINHFFCDFPAVVKLVCGDTSINEKMALVEVALLGLIPFALIFMSYMCIASTIFKMSSVEGRQKAFSTCSSHLMVVMLFYGSGITVYLKPKSHFHDTDKSLSLLYTVLPPLFNPLIYSLRKEVRVALRSVFSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JM91</accession>
    <name>A0A670JM91_PODMU</name>
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        <recommendedName>
            <fullName evidence="1">Pyrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JM91"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025536.1">
        <property type="protein sequence ID" value="ENSPMRP00000024072.1"/>
        <property type="gene ID" value="ENSPMRG00000015579.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235085"/>
    <dbReference type="OMA" id="FNSIRWG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="CDD" id="cd08321">
        <property type="entry name" value="Pyrin_ASC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02758">
        <property type="entry name" value="PYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01289">
        <property type="entry name" value="PYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50824">
        <property type="entry name" value="DAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="93" mass="10767" checksum="516D3D49917F236B" modified="2020-06-17" version="1">MEKTITDSLVSTLENLRENELKKFKLKLHEFPVKKGYDNIPRGTLEKADVVDLSLLLLNFYTGDYAAQVTAEVLRTINCRDEAERLLGHCRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JN54</accession>
    <name>A0A670JN54_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JN54"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027408.1">
        <property type="protein sequence ID" value="ENSPMRP00000025826.1"/>
        <property type="gene ID" value="ENSPMRG00000016711.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230359"/>
    <dbReference type="OMA" id="LCPGRNY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000355">
        <property type="entry name" value="Chemokine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001277">
        <property type="entry name" value="CXCR4/ACKR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF686">
        <property type="entry name" value="C-C CHEMOKINE RECEPTOR TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00657">
        <property type="entry name" value="CCCHEMOKINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00645">
        <property type="entry name" value="CXCCHMKINER4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="45"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="361" mass="41405" checksum="52970C0A4DD3E43C" modified="2020-06-17" version="1">MPDYGITTFDYNIDAGLVYSHAMEVFATTFLPPFYSLVLIFGLLGNSLVVLILIRYKKLKSMTDIYLLNLAISDLLVIFSLPFWAYYAGHEWIFGVAMCKILFGIYYIGFYCGSFFIILLTIDRYLAIVHAVFALKARMITYGTVTSVVTWVVVLLASVPEFVFHHVQKANETYECTIHYPSENEKVWKQFLTLMKFILGLAIPAVIIVFCYMQIIKILIKGRNERKQKAVKLIAVIMIKAFKLIAVIMVVFFLFWMPYNIALLLRTFQDSFFSFNSENNIEGKVAFGVEVTRVIALVHCCINPVIYAFLGEKFRKYTSIFFQKCLLAPLCRLCPGRNYPILERSTSSYISSTEHEISIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JSR6</accession>
    <name>A0A670JSR6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Fibroblast growth factor receptor</fullName>
            <ecNumber evidence="26">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="37" type="primary">FGFR1</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="37" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25 26">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="26">Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.</text>
    </comment>
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    <dbReference type="OMA" id="YVQILKX"/>
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        <property type="component" value="Chromosome 15"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:glutamatergic synapse"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:receptor complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:fibroblast growth factor binding"/>
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        <property type="term" value="F:heparin binding"/>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="term" value="F:receptor-receptor interaction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:SH2 domain binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060117">
        <property type="term" value="P:auditory receptor cell development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060445">
        <property type="term" value="P:branching involved in salivary gland morphogenesis"/>
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        <property type="term" value="P:calcium ion homeostasis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cardiac muscle cell proliferation"/>
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        <property type="term" value="P:cell maturation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cementum mineralization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071344">
        <property type="term" value="P:diphosphate metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:embryonic limb morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001837">
        <property type="term" value="P:epithelial to mesenchymal transition"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060484">
        <property type="term" value="P:lung-associated mesenchyme development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010463">
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    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090272">
        <property type="term" value="P:negative regulation of fibroblast growth factor production"/>
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    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001759">
        <property type="term" value="P:organ induction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:paraxial mesoderm development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 26 28" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="24" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="19 29" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="21 30" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="23" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="17 26 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 26 31" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 34" id="KW-0732">Signal</keyword>
    <keyword evidence="8 26" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="18 26" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="34">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025679932" description="Fibroblast growth factor receptor" evidence="34">
        <location>
            <begin position="22"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="36">
        <location>
            <begin position="33"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="36">
        <location>
            <begin position="150"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="36">
        <location>
            <begin position="253"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="35">
        <location>
            <begin position="476"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="778"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="32">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="778"/>
            <end position="790"/>
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    </feature>
    <feature type="active site" description="Proton acceptor" evidence="27">
        <location>
            <position position="621"/>
        </location>
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    <feature type="binding site" evidence="28">
        <location>
            <begin position="482"/>
            <end position="488"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <location>
            <begin position="560"/>
            <end position="562"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
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        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="30">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="30">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="30">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="30">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="30">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="30">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="30">
        <location>
            <position position="328"/>
        </location>
    </feature>
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            <begin position="54"/>
            <end position="100"/>
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            <begin position="176"/>
            <end position="228"/>
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    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="275"/>
            <end position="339"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000628"/>
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        <source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000628-2"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000628-3"/>
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    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-4"/>
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    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027471.1"/>
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    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="820" mass="91855" checksum="2D7A47F93F5C636C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTE9</accession>
    <name>A0A670JTE9_PODMU</name>
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        <recommendedName>
            <fullName evidence="3">Myelin protein P0</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Myelin peripheral protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Myelin protein zero</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MPZ</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the myelin P0 protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JTE9"/>
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        <property type="protein sequence ID" value="ENSPMRP00000027721.1"/>
        <property type="gene ID" value="ENSPMRG00000017888.1"/>
    </dbReference>
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    <dbReference type="OMA" id="WVGDPHW"/>
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        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098743">
        <property type="term" value="P:cell aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098742">
        <property type="term" value="P:cell-cell adhesion via plasma-membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="IgV_P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000193">
        <property type="entry name" value="Myelin protein zero-like 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000920">
        <property type="entry name" value="Myelin_P0-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047014">
        <property type="entry name" value="Myelin_P0_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019566">
        <property type="entry name" value="MYP0_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869">
        <property type="entry name" value="MYELIN P0 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869:SF7">
        <property type="entry name" value="MYELIN PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10570">
        <property type="entry name" value="Myelin-PO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00213">
        <property type="entry name" value="MYELINP0"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="239" mass="27042" checksum="E423895ABC3671EA" modified="2020-06-17" version="1">MGTPGSSGRERALLLLTVLVSTMVLTPTLAIHVYTDREVHGTVGSKVTLSCSFWSREWISDDISITWHFQPENGRDSVSIFHYAKGQPYIDDIGRFKERIEWIGNPRWKDGSIVIHNLDYIDNGTYTCDVKNPPDIVGKSSQVLLYVFENVPTRYGVVLGAVIGGVLLVVFVVLVIAYLIRYCWLRRQATLQRRLSAMEKGKLRLGKDSSKRGRQQPVLYAMLDHSRLTKSASDKRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTR1</accession>
    <name>A0A670JTR1_PODMU</name>
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        <submittedName>
            <fullName evidence="6">Phosphofurin acidic cluster sorting protein 1</fullName>
        </submittedName>
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    <gene>
        <name evidence="6" type="primary">PACS1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PACS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JTR1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028907.1">
        <property type="protein sequence ID" value="ENSPMRP00000027250.1"/>
        <property type="gene ID" value="ENSPMRG00000017249.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183209"/>
    <dbReference type="OMA" id="TSAITRX"/>
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        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030137">
        <property type="term" value="C:COPI-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002260">
        <property type="term" value="P:lymphocyte homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057541">
        <property type="entry name" value="PACS1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF16">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_PACS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="105"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="4">
        <location>
            <begin position="555"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="549"/>
        </location>
    </feature>
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        <location>
            <begin position="768"/>
            <end position="798"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="955" mass="104108" checksum="0FC9CF537143344A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUR0</accession>
    <name>A0A670JUR0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 13 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLC13A2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JUR0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028833.1">
        <property type="protein sequence ID" value="ENSPMRP00000027179.1"/>
        <property type="gene ID" value="ENSPMRG00000017456.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234550"/>
    <dbReference type="OMA" id="MLAINSW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015139">
        <property type="term" value="F:alpha-ketoglutarate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015138">
        <property type="term" value="F:fumarate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017153">
        <property type="term" value="F:sodium:dicarboxylate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071285">
        <property type="term" value="P:cellular response to lithium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="538" mass="58634" checksum="F108885B7B343F6F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUR9</accession>
    <name>A0A670JUR9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA methyltransferase activator subunit 11-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRMT112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
                <person name="Andersson L."/>
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            <authorList>
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            </authorList>
        </citation>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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    </dbReference>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="488" mass="52922" checksum="01864FC8C1EB1253" modified="2020-06-17" version="1">MKCGFFRGTGCGGESTSNDVFGCVGLGFRLSGSLGEDGGWWRSWLQQSLQTVKDKSTEALEFMKRDLTEFTQVVQHDTACTIAATASVVKEKLAARLYSLQSDPATYCNEPDGPSQLFEAWLLHFNLEEKKGEISELLVNSPSIRSLYSKMVPVAVSHSEFWQRYFYKVHQLEQEEVRREVLKQRAEQSVHSEEPGWEEEEEEFLGSSSSQSNVCSQSPQEVKPASPTSAAVLTPTLEASVESWAMLSTAPAEVTPSESSESISLVTQVANPAATAAAAAAPAASPAVPLQTGAQLSGAGDISQRLQEATAEEQTSLAKPVEPAHPSPAAPEAKPSPEQPKEQVEAKPVSRTETLREDGPMDLRLFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQLALSKVDISGEVSPCRQAGPEDCPWGSWDGGRTYYKGLLKKGCCLVTGLLPGKGCRVAGLRGLSKETMRTLFFFILLLTPL</sequence>
</entry>
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    <accession>A0A670JVK6</accession>
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        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:immune response-regulating signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Killer cell immunoglobulin-like receptor"/>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="Tc1-like_DDE_dom"/>
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        <property type="entry name" value="MHC CLASS I NK CELL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738:SF186">
        <property type="entry name" value="OSTEOCLAST-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR"/>
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    </dbReference>
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        <property type="entry name" value="DDE_3"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="521" mass="59116" checksum="81C71E8B00C7FAE2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVN3</accession>
    <name>A0A670JVN3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AP2B1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JVN3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031096.1">
        <property type="protein sequence ID" value="ENSPMRP00000029318.1"/>
        <property type="gene ID" value="ENSPMRG00000018527.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155206"/>
    <dbReference type="OMA" id="PECNEWG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035904">
        <property type="term" value="P:aorta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098884">
        <property type="term" value="P:postsynaptic neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003281">
        <property type="term" value="P:ventricular septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000002">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000001">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000003">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="724"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="10">
        <location>
            <begin position="840"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="962" mass="106748" checksum="811B3726C72404E2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWI9</accession>
    <name>A0A670JWI9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-3 adrenergic receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-3 adrenoreceptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ADRB3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ARRDC3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028564441.1">
        <property type="nucleotide sequence ID" value="XM_028708608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JWI9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030567.1">
        <property type="protein sequence ID" value="ENSPMRP00000028816.1"/>
        <property type="gene ID" value="ENSPMRG00000018633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585734"/>
    <dbReference type="KEGG" id="pmua:114585734"/>
    <dbReference type="CTD" id="155"/>
    <dbReference type="GeneTree" id="ENSGT00940000158663"/>
    <dbReference type="OMA" id="CAFASNI"/>
    <dbReference type="OrthoDB" id="5983033at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015052">
        <property type="term" value="F:beta3-adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051379">
        <property type="term" value="F:epinephrine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051380">
        <property type="term" value="F:norepinephrine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055118">
        <property type="term" value="P:negative regulation of cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045986">
        <property type="term" value="P:negative regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002025">
        <property type="term" value="P:norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15959">
        <property type="entry name" value="7tmA_Beta3_AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000057">
        <property type="entry name" value="Beta-1 adrenergic receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002233">
        <property type="entry name" value="ADR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000681">
        <property type="entry name" value="ADRB3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF3">
        <property type="entry name" value="BETA-3 ADRENERGIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01103">
        <property type="entry name" value="ADRENERGICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00563">
        <property type="entry name" value="ADRENRGCB3AR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="20">
        <location>
            <begin position="156"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="468"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="556" mass="60061" checksum="7461FCDE0E71B0A8" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWY5</accession>
    <name>A0A670JWY5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane BAX inhibitor motif containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMBIM4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028602522.1">
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        <property type="protein sequence ID" value="ENSPMRP00000027282.1"/>
        <property type="gene ID" value="ENSPMRG00000017603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605413"/>
    <dbReference type="KEGG" id="pmua:114605413"/>
    <dbReference type="CTD" id="51643"/>
    <dbReference type="GeneTree" id="ENSGT01050000244940"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:Golgi stack"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:locomotory behavior"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="240" mass="26961" checksum="21510C4A0D303756" modified="2020-06-17" version="1">MMAAESPSSYPRTSIEDDFNYGTNVASASVHIRMAFLRKVYSILSVQIFLTTVTSAAFLYSETIRTFVHESPAVLLVSVLGSLVVIVALTLYRHQHPLNLYLLFGFTLLEALTVAITVTFYEVSVVLQAFILTTAVFFALTLYTLQSKRDFSKVGAGLFACLWILLLSSFLRLFFYSEVLEVVLAAGGALLFCGFIIYDTHLLMHKLSPEEYILASINLYLDIINLFLHLLRLLEAFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JY05</accession>
    <name>A0A670JY05_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JY05"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031130.1">
        <property type="protein sequence ID" value="ENSPMRP00000029351.1"/>
        <property type="gene ID" value="ENSPMRG00000018975.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000806">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000540">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K254</accession>
    <name>A0A670K254_PODMU</name>
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            <fullName evidence="18">Proton-coupled zinc antiporter SLC30A8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 30 member 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Zinc transporter 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SLC30A8</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc:proton antiporter activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:zinc ion import into organelle"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="zinc transporter 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF37">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="22">
        <location>
            <begin position="72"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="23">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037214"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="379" mass="42427" checksum="20D913560B671712" modified="2020-06-17" version="1">FRVSPVLRGQMTLRHSRVGAPGGQCLVKTEVPVNRSEKSANVEPVSRYHCHNHSEAYEERKGEERQAKKKLYLASTICCIFLIAEVVGGHMAGSLAVMMDASHVMVDLMSFLISIFSLWLSSKPPSKRFTYGWHRAEILGAFLSIIVIWVVTGILTFLAVMRLWHPHYEIESTVMLITSACAVIANIILSFTLHPKGKEHLHHGHKAHHCRPSDSEQVLNNASIRAAFVHAIGDLFQSLSVLISALIIFFKPEYKIADPICTFVFSVLILATTLTILRDISVVLMEGSPGVLPYDEVKERILAIEKVESVHSLHLWCLTMNQILLSAHIVTARSSNLSHKVAFARGSNGHYISSSGNQIPRWQPRIRETIKVLTKQYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4M5</accession>
    <name>A0A670K4M5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A670K4M5"/>
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        <property type="protein sequence ID" value="ENSPMRP00000031746.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome 13"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
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        <property type="entry name" value="GPCR_3"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
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        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
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        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0675">Receptor</keyword>
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        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
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            <begin position="567"/>
            <end position="588"/>
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    </feature>
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            <begin position="600"/>
            <end position="623"/>
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            <begin position="643"/>
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            <begin position="688"/>
            <end position="711"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
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        <location>
            <begin position="529"/>
            <end position="779"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="787" mass="88604" checksum="79854AB38D9F9A23" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4S9</accession>
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        <submittedName>
            <fullName evidence="6">HECT and RLD domain containing E3 ubiquitin protein ligase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HERC5</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSPMRG00000020206.1"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042296">
        <property type="term" value="F:ISG15 transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of defense response to virus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCCNDNSATION"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="113"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="158"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="211"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="263"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="689" mass="76992" checksum="C1025E1E26DEF485" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K587</accession>
    <name>A0A670K587_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Polycystin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="primary">PKD2</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polycystin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028599416.1">
        <property type="nucleotide sequence ID" value="XM_028743583.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000031360.1"/>
        <property type="gene ID" value="ENSPMRG00000020319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603974"/>
    <dbReference type="KEGG" id="pmua:114603974"/>
    <dbReference type="CTD" id="5311"/>
    <dbReference type="GeneTree" id="ENSGT00940000159025"/>
    <dbReference type="OMA" id="RHEHRSC"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:basal cortex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cation channel complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070062">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030027">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140494">
        <property type="term" value="C:migrasome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002133">
        <property type="term" value="C:polycystin complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048763">
        <property type="term" value="F:calcium-induced calcium release activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043398">
        <property type="term" value="F:HLH domain binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:voltage-gated sodium channel activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035904">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <keyword evidence="12 30" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="11 30" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="26" id="KW-0966">Cell projection</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="28" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="24" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="25" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="22 30" id="KW-0406">Ion transport</keyword>
    <keyword evidence="23 33" id="KW-0472">Membrane</keyword>
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    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20 33" id="KW-1133">Transmembrane helix</keyword>
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    <keyword evidence="18" id="KW-0851">Voltage-gated channel</keyword>
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            <begin position="206"/>
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            <begin position="405"/>
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    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="445"/>
            <end position="471"/>
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    <feature type="transmembrane region" description="Helical" evidence="33">
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            <begin position="483"/>
            <end position="509"/>
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    <feature type="transmembrane region" description="Helical" evidence="33">
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            <begin position="580"/>
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        <location>
            <begin position="642"/>
            <end position="663"/>
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        <location>
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            <end position="768"/>
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            <begin position="1"/>
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            <begin position="898"/>
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        <location>
            <begin position="1"/>
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            <begin position="11"/>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="13">
        <source>
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    <evidence type="ECO:0000256" key="14">
        <source>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00040113"/>
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        <source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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        <source>
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    <sequence length="952" mass="107605" checksum="37EAFD9A7A22B01F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5I2</accession>
    <name>A0A670K5I2_PODMU</name>
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        <recommendedName>
            <fullName evidence="13">medium-chain acyl-CoA ligase</fullName>
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        <name evidence="17" type="primary">ACSM5</name>
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    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <reaction evidence="14">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:48341"/>
        </physiologicalReaction>
    </comment>
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        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSPMRP00000030117.1"/>
        <property type="gene ID" value="ENSPMRG00000019475.1"/>
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        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AMP-bd_C_sf"/>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
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        <property type="entry name" value="Mitochondrial_ACSM"/>
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    <dbReference type="PANTHER" id="PTHR43605">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE ACSM5, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AMP_BINDING"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="74"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="16">
        <location>
            <begin position="481"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="575" mass="64747" checksum="2DE55A75B641AA80" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5L7</accession>
    <name>A0A670K5L7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartate aminotransferase</fullName>
            <ecNumber evidence="10">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GOT2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028595265.1">
        <property type="nucleotide sequence ID" value="XM_028739432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K5L7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034798.1">
        <property type="protein sequence ID" value="ENSPMRP00000032818.1"/>
        <property type="gene ID" value="ENSPMRG00000021268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601856"/>
    <dbReference type="KEGG" id="pmua:114601856"/>
    <dbReference type="CTD" id="2806"/>
    <dbReference type="GeneTree" id="ENSGT00950000183082"/>
    <dbReference type="OMA" id="VGACTIV"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015908">
        <property type="term" value="P:fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019550">
        <property type="term" value="P:L-glutamate catabolic process to aspartate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045471">
        <property type="term" value="P:response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000160">
        <property type="entry name" value="Similar to aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025657889" description="Aspartate aminotransferase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="57"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="429" mass="47448" checksum="AF8297C7A15A537F" modified="2020-06-17" version="1">MALLHSAAAGSRLLLLPPPCLASLAARASSWWANVEMGPPDPILGVTEAFKRDTSSKKMNLGVGAYRDDNGKPYVLNCVRKAEAEIAAKKLDKEYLPIAGLAEFNKASAELALGETHEVIQSGRYVTVQTISGTGSLRVGANFLQRFFKSSRDVYLPKPSWGNHTPIFRDAGLQLQSYRYYEPKTCGFDFAGALDDISKIPEKSIVLFHACAHNPTGVDPRPEQWKELAAVVKKRNLFTFFDMAYQGFASGDINKDAWAVRHFIEQGINVVLSQSYAKNMGLYGERVGAFTVVCHDSEEAKRVESQLKILIRPMYSNPPLNGARIASTILNNPGLRKEWLVEVKGMADRIIGMRTQLVANLKKEGSPHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVAYLAHAIHQVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K5V5</accession>
    <name>A0A670K5V5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K5V5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032904.1">
        <property type="protein sequence ID" value="ENSPMRP00000031019.1"/>
        <property type="gene ID" value="ENSPMRG00000020105.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="ACITIKE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="492"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1253" mass="149685" checksum="8A3E2838E869EBB9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7M8</accession>
    <name>A0A670K7M8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Meteorin, glial cell differentiation regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">METRN</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the meteorin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028561744.1">
        <property type="nucleotide sequence ID" value="XM_028705911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K7M8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032647.1">
        <property type="protein sequence ID" value="ENSPMRP00000030782.1"/>
        <property type="gene ID" value="ENSPMRG00000019945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584245"/>
    <dbReference type="KEGG" id="pmua:114584245"/>
    <dbReference type="CTD" id="79006"/>
    <dbReference type="GeneTree" id="ENSGT00390000001390"/>
    <dbReference type="OMA" id="VHWGPRE"/>
    <dbReference type="OrthoDB" id="6092325at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060019">
        <property type="term" value="P:radial glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051998">
        <property type="entry name" value="Meteorin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593:SF2">
        <property type="entry name" value="METEORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025644732" evidence="6">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="298" mass="33328" checksum="42459E58730F1FEF" modified="2020-06-17" version="1">MSLALGLLGLVLLHTALCNYSEDQCSWRGSGLSQESGSVEQISLHCAEGSLEWLYPAGALRLSLFPRLPTGTTGRENPRRVTACIKSSNSFRGAQIYLERDGVLELLLSEADATLQPKVRCFSWLPKEKVALFLQSTLHQDISRRIAAFRYELRGDWNSRFSWPSRNLSMEDAGSCRPCNNTEILMAVCTSDFVIRGNIRTVSNDMESQESIISVSATRIHRQKFALFQPVGKYGKSTGSIRTLLRCGVKPGPGSFLFTGWLHFGEAWLSCAPRYKDFRHIYEGARQAHENPCEVSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBD7</accession>
    <name>A0A670KBD7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TREX2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670KBD7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035720.1">
        <property type="protein sequence ID" value="ENSPMRP00000033670.1"/>
        <property type="gene ID" value="ENSPMRG00000021832.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012715"/>
    <dbReference type="OMA" id="WAHVEPM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06136">
        <property type="entry name" value="TREX1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000046">
        <property type="entry name" value="Three prime repair exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF24">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="12">
        <location>
            <begin position="45"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="259" mass="28967" checksum="F8339BE4A5E610B4" modified="2020-06-17" version="1">STQLTEAVPPPKSAPFGGDIFTHDFPKTTQQLPHLGCAPLQDFQTFVFLDLETTGLPHDQPRLAELCLFAVHRRSLQCSLLPGTPQLPRIIDKLTLCVDPQKPFTLEAERITGLSNRNLEENCKADFNRGVVDILKGFLQRQMGPICLVAHNGLGFDFPLLRAELWRVDTDLPPSTGCLDTLPALKELERSPGMSYQLGALFRHFYGREPVRAHSAEGDVVTLLLVFLAKAPELMTWAARNARSWGEIPPMYLRSRSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBV2</accession>
    <name>A0A670KBV2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">TGF-beta-activated kinase 1 and MAP3K7-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mitogen-activated protein kinase kinase kinase 7-interacting protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">TGF-beta-activated kinase 1-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">TAB1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines. Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation. In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Interacts with TRAF6 and MAPK14; these interactions allow MAPK14 autophosphorylation. Interacts with STING1; interaction takes place following cGAMP activation and promotes TAB1 recruitment to the endoplasmic reticulum, triggering MAP3K7/TAK1 activation and STING1 phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptogyrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KBV2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037064.1">
        <property type="protein sequence ID" value="ENSPMRP00000034953.1"/>
        <property type="gene ID" value="ENSPMRG00000022622.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048276"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035904">
        <property type="term" value="P:aorta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003279">
        <property type="term" value="P:cardiac septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140896">
        <property type="term" value="P:cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141111">
        <property type="term" value="P:positive regulation of cGAS/STING signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000014">
        <property type="entry name" value="TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF7">
        <property type="entry name" value="SYNAPTOGYRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="21">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="22">
        <location>
            <begin position="178"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="564"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="564"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="652" mass="71771" checksum="62BE15BD7F60DA52" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KBV3</accession>
    <name>A0A670KBV3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Taste receptor type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114588012</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor T2R family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KBV3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034246.1">
        <property type="protein sequence ID" value="ENSPMRP00000032292.1"/>
        <property type="gene ID" value="ENSPMRG00000020933.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286961"/>
    <dbReference type="OMA" id="YIVFPRT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033038">
        <property type="term" value="F:bitter taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000055">
        <property type="entry name" value="Taste receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007960">
        <property type="entry name" value="TAS2R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11394:SF47">
        <property type="entry name" value="TASTE RECEPTOR TYPE 2 MEMBER 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05296">
        <property type="entry name" value="TAS2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="3 12" id="KW-0919">Taste</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="306" mass="35050" checksum="F310C54D880060B3" modified="2020-06-17" version="1">AVITNRILLRFTILAIESAIAFLGNGFIIAVNGHRWLQNWKMAPCDFLLTSLSISRILLQLTAMVSSLLYYNSPLSYMRIYDEICTFLWLFLSHVSLWCATWLNIFYCVKVTNFPHHLFLWLKLRIDVLGPRLFGMVIIALMLFSVHPTILHFENKKACNLSGTLTQNASLSKVCKDPFFVFRTLQLCSLCMSFILSVTASMVLLISLWRHRKNMKKSGSVIKDLSTQVYLNVMKSLLFSLFFNVTYFVSLIIPMFSLYRNGTNGQLVSDIVLSAVPSAHTMSLILSNPKLKEILMHILHIRQRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KD59</accession>
    <name>A0A670KD59_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KD59"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036888.1">
        <property type="protein sequence ID" value="ENSPMRP00000034781.1"/>
        <property type="gene ID" value="ENSPMRG00000022526.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018141"/>
    <dbReference type="OMA" id="RSHKATW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
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        <property type="entry name" value="RT_dom"/>
    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RT_POL"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="558"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1004" mass="115623" checksum="6B7D1F6B91CF2E48" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDF7</accession>
    <name>A0A670KDF7_PODMU</name>
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        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KDF7"/>
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        <property type="protein sequence ID" value="ENSPMRP00000032847.1"/>
        <property type="gene ID" value="ENSPMRG00000021291.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium channel regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="calcium-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000037">
        <property type="entry name" value="calcium-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043582">
        <property type="entry name" value="CaBP1/2/4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45917">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="200" mass="22566" checksum="473489EE370C0F6E" modified="2020-06-17" version="1">MQNTLGPACIFLRKGIAEKQGERELGADEIEELREAFDEFDKDKDGYISCKDLGNLMRTMGYMPTEMELIELSQQINMNLGGRVDFEDFVEMMTPKLLAETAGMIGLQEMRDAFKEFDTNGDGEITLDELYQAMQRLMGERLTSREIADVVKEADVNGDGTVDFEGEMHSGNIGLMERDYRLIGIQGERLKALKVWGDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDT6</accession>
    <name>A0A670KDT6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Alpha-tectorin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TECTA</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin. Interacts with CEACAM16.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000037135.1">
        <property type="protein sequence ID" value="ENSPMRP00000035021.1"/>
        <property type="gene ID" value="ENSPMRG00000022663.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183155"/>
    <dbReference type="OMA" id="RVQTGCV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
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        <location>
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            <begin position="1804"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="2153" mass="239138" checksum="9D61A81504A034F0" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KE79</accession>
    <name>A0A670KE79_PODMU</name>
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        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GGCT</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_028750188.1"/>
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        <property type="nucleotide sequence ID" value="XM_028750189.1"/>
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        <property type="nucleotide sequence ID" value="XM_028750191.1"/>
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        <property type="component" value="Chromosome 12"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:release of cytochrome c from mitochondria"/>
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    </dbReference>
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        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
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        <property type="entry name" value="G-Glutamylcylcotransferase"/>
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    </dbReference>
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        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="107"/>
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    </feature>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <location>
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        <ligand>
            <name>substrate</name>
        </ligand>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="198" mass="22065" checksum="FE73FC7FE5D79FA0" modified="2020-06-17" version="1">METFKHCTLTGLGEGLDFQSFGNESISYFAYGSNLLRERIMLRNPSAVFLTLAQLLDYKLAFGSHHGKPSSNWHGSTATIIHSPGDEVWGVVWRMSPTDLPSLDRQEGVEQGIYIPIEVTVQTQEGKTLKSRSYQMTDYVLGLPSPQYKKVICMGAKQNGLPVDYQKKLDSIQTNDYAGPVPVFDEIEAALSENEITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIL4</accession>
    <name>A0A670KIL4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
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                <consortium name="Ensembl"/>
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        </citation>
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    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSPMRT00000039072.1">
        <property type="protein sequence ID" value="ENSPMRP00000036896.1"/>
        <property type="gene ID" value="ENSPMRG00000023769.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163503"/>
    <dbReference type="OMA" id="HDVSQTC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
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    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
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        <property type="entry name" value="Ig-like_ZP"/>
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        <property type="entry name" value="ZP-C"/>
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        <property type="entry name" value="ZP-C_dom"/>
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        <property type="entry name" value="ZP_dom"/>
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    </dbReference>
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        <property type="entry name" value="ZONA PELLUCIDA PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
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    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025598449" description="ZP domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="618"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="909" mass="101601" checksum="193B2314FFB17252" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJU9</accession>
    <name>A0A670KJU9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein sprouty homolog 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SPRY2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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                <person name="Soler L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="9" key="2">
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sprouty family.</text>
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    <dbReference type="KEGG" id="pmua:114596550"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:establishment of mitotic spindle orientation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060437">
        <property type="term" value="P:lung growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031345">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="InterPro" id="IPR007875">
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    <dbReference type="InterPro" id="IPR051192">
        <property type="entry name" value="Sprouty_domain"/>
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        <property type="entry name" value="PROTEIN SPROUTY HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010964"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018854"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035924.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="311" mass="34293" checksum="37920C286AFA19B8" modified="2020-06-17" version="1">METRAQNGSGSQPLLQSQHDSGRQYGEPDLRDVLAQQVHVLSLDQIKAIRNTNEYTEPPTVAPRPGVKPAPRLPLQHKSERANGLTDHLSRVQHPQVHVSSRLPLSRSISMASTGSRASTRTSTSSNSSEQRLLGSSLGTVADGIVRVQPKSELKPSELKPPSKEDLHLHAYRCEDCGKCKCKECTYPRTLPSCWICDKQCLCSAQNVVDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSTMGVVSLVLPCLWCYLPAKGCLKLCQGCYDQVNRPGCRCKHSNTVCCKVPNVPPRNFEKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKK2</accession>
    <name>A0A670KKK2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GIT ArfGAP 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GIT1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KKK2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037379.1">
        <property type="protein sequence ID" value="ENSPMRP00000035252.1"/>
        <property type="gene ID" value="ENSPMRG00000022681.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159604"/>
    <dbReference type="OMA" id="IDHKNGH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044305">
        <property type="term" value="C:calyx of Held"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001957">
        <property type="term" value="P:intramembranous ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061743">
        <property type="term" value="P:motor learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106015">
        <property type="term" value="P:negative regulation of inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090063">
        <property type="term" value="P:positive regulation of microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099171">
        <property type="term" value="P:presynaptic modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036465">
        <property type="term" value="P:synaptic vesicle recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000013">
        <property type="entry name" value="ARF GTPase-activating protein GIT1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000003">
        <property type="entry name" value="ARF GTPase-activating protein GIT2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.330:FF:000002">
        <property type="entry name" value="ARF GTPase-activating protein GIT2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000015">
        <property type="entry name" value="ARF GTPase-activating protein GIT2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047161">
        <property type="entry name" value="GIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032352">
        <property type="entry name" value="GIT1/2_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097:SF1">
        <property type="entry name" value="ARF GTPASE-ACTIVATING PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16559">
        <property type="entry name" value="GIT_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="12">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="356"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="435"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="768" mass="85002" checksum="EE268C01997DB0FF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KL26</accession>
    <name>A0A670KL26_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid phosphatase-related protein type 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lipid phosphate phosphatase-related protein type 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PLPPR2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028567844.1">
        <property type="nucleotide sequence ID" value="XM_028712011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KL26"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038768.1">
        <property type="protein sequence ID" value="ENSPMRP00000036599.1"/>
        <property type="gene ID" value="ENSPMRG00000023599.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587574"/>
    <dbReference type="KEGG" id="pmua:114587574"/>
    <dbReference type="CTD" id="64748"/>
    <dbReference type="GeneTree" id="ENSGT00940000158145"/>
    <dbReference type="OMA" id="NAYIQPF"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000002">
        <property type="entry name" value="phospholipid phosphatase-related protein type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF15">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="125"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="393" mass="42716" checksum="AAE962A27CAC793B" modified="2020-06-17" version="1">MAGDKQELKRSISIIPCFVFVELVIMAGTVVLAYHFEYTNTFPVHLQGFFCYDSAYAKPYPGPEDTSRAPPVLVYSLVTAVPTVTILVGELAAFFLQPERREEKTIISGECCYFNPLLRRIIRFLGIYSFGLFTTTIFANAGQVVTGNQTPHFLSVCRPNYTALGCQAPPGTIYVTDKAACTGNPVLVTAARKAFPSKDAALSAYAVAYTVMYVTLVFRLKGSRLAKPSLCLALLCPAFLVGVVRVAEYRNHWSDVLAGFLTGGAIAAFLVTCVVNNFQSSPPTAKKTTPTESSLPSVPVMGLPCVDSSLEKLSVAQQVRDPPEEQEFSTLLSRGLERQLARSLRLAAPGNAAMARPYEITELCSQRSPDPQLCLFPTTPDVLIPSRSVTSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLK4</accession>
    <name>A0A670KLK4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CLCN7</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KLK4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037730.1">
        <property type="protein sequence ID" value="ENSPMRP00000035592.1"/>
        <property type="gene ID" value="ENSPMRG00000023016.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158458"/>
    <dbReference type="OMA" id="KCDHNGF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062158">
        <property type="term" value="F:chloride:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030321">
        <property type="term" value="P:transepithelial chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03685">
        <property type="entry name" value="ClC_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000018">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002249">
        <property type="entry name" value="CIC-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01118">
        <property type="entry name" value="CLCHANNEL7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="803"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="867" mass="95066" checksum="9417B8322A881495" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KLN9</accession>
    <name>A0A670KLN9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium sodium-activated channel subfamily T member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KCNT1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KLN9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039105.1">
        <property type="protein sequence ID" value="ENSPMRP00000036929.1"/>
        <property type="gene ID" value="ENSPMRG00000023762.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156880"/>
    <dbReference type="OMA" id="GMCSIEH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005228">
        <property type="term" value="F:intracellular sodium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000011">
        <property type="entry name" value="Potassium channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000034">
        <property type="entry name" value="Potassium channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000069">
        <property type="entry name" value="Potassium sodium-activated channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF14">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY T MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="15">
        <location>
            <begin position="347"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="15">
        <location>
            <begin position="770"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1194"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1220" mass="139375" checksum="335C7ED03F6EA872" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HL39</accession>
    <name>A0A670HL39_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase F(0) complex subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">F-ATPase protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Proton-conducting channel, ATP synthase F(0) complex subunit a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>H(+)(in) = H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Interacts with DNAJC30; interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HL39"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000567.1">
        <property type="protein sequence ID" value="ENSPMRP00000000539.1"/>
        <property type="gene ID" value="ENSPMRG00000000404.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00960000189284"/>
    <dbReference type="OMA" id="FNELCTH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="87" mass="9317" checksum="F1F7F33DCA2CC656" modified="2020-06-17" version="1">ILVIIETASLLICPIALGVCLTANLTARHLLIQLTSTAVLALINTITLTASIALITLILLTCLEIAVALIQAYVFVLLLTLYLQENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HL89</accession>
    <name>A0A670HL89_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 586-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114592220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HL89"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000627.1">
        <property type="protein sequence ID" value="ENSPMRP00000000599.1"/>
        <property type="gene ID" value="ENSPMRG00000000443.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159965"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000056">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002239">
        <property type="entry name" value="Zinc finger protein 226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002196">
        <property type="entry name" value="zinc finger protein 850-like isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="14">
        <location>
            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="645" mass="74066" checksum="6C7AA769BCC19241" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNR7</accession>
    <name>A0A670HNR7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ohanin/vespryn family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HNR7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000695.1">
        <property type="protein sequence ID" value="ENSPMRP00000000662.1"/>
        <property type="gene ID" value="ENSPMRG00000000504.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234669"/>
    <dbReference type="OMA" id="DAMIFRQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12888">
        <property type="entry name" value="SPRY_PRY_TRIM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="105"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="294" mass="34042" checksum="023F445890C7CA55" modified="2020-06-17" version="1">MQKAEEKFRELHQFLLNQIKEVEKEIAGRRDEHRARLSRKLSSLERIIQEMEEKSQQPASELLQDVGSTLQRCERTERLENQLAFPPELKEEASRFCDMNLRLEEVLKEFKDAMIFRQQFQKANVTLDPDTAHSCLILSKDGKSVRLADRKRVVPNNPERFNNWPSVLGREEFTADRLFWEVTVGSEGEWAVGVARKSIGRKGRFPFSPEGGLWALEKMGNGYWAWNPPYNTPLSLREKPRRIRVTLDYEGGRVSFSDADSGAELYTFSGASFSGETLLPFFRLWGNETHLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQC7</accession>
    <name>A0A670HQC7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VPS52</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQC7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002146.1">
        <property type="protein sequence ID" value="ENSPMRP00000002019.1"/>
        <property type="gene ID" value="ENSPMRG00000001358.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008815"/>
    <dbReference type="OMA" id="IHVVMVE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="103"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="292"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="726" mass="83085" checksum="D0A9937091250E8E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQI4</accession>
    <name>A0A670HQI4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQI4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001406.1">
        <property type="protein sequence ID" value="ENSPMRP00000001322.1"/>
        <property type="gene ID" value="ENSPMRG00000000998.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="CGKFYRD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004135">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000514">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000588">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000466">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000038">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000990">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041697">
        <property type="entry name" value="Znf-C2H2_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF152">
        <property type="entry name" value="SI:DKEY-210J14.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16622">
        <property type="entry name" value="zf-C2H2_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="443" mass="50543" checksum="FAD6134EF10801D5" modified="2020-06-17" version="1">MEVQPQEYSPTERSFNRPQAPSLVTRHIWVSQNGFLSPRSSLLKEGNGEGSQNSGGPCPMGITKKPYKFMECEKREEKQFESMECGKSFIDSGTLGKHQQTHTGEKPFKCMECGKSFGWSSNLRIHKHTHTGEKPYKCKECGKSFSQKGSLRIHQRTHTGVKPYKCYECGKSFSQIGHIRNHQRTHTGEKPYKCMECGKSFTDGGSFRKHQQTHTGEKPFKCMECVKSFSQRRSLIIHQRIHTGEKPFKCLECGKSFSTNGRLNSHNKTHTGEKPFECMLCDKSFTESRKLRIHHRTHTGEKPYKCMDCGKSFSCSGAVRKHQRTHTGEKPFKCMECGKCFTCSGAVRRHQWTHSGEKPFKCMECGKSFSRSGNLNLHHQIHTGEKPFKCTECGKSFNHSGTLRQHQWTHTGEKPFKCKECGKGFTNVGNVRRHQQTHSGTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HQY3</accession>
    <name>A0A670HQY3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HQY3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001732.1">
        <property type="protein sequence ID" value="ENSPMRP00000001630.1"/>
        <property type="gene ID" value="ENSPMRG00000001210.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162179"/>
    <dbReference type="OMA" id="HIEETTH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001772">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001024">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF157">
        <property type="entry name" value="ZINC FINGER PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="455" mass="51440" checksum="8B5A644865A820B7" modified="2020-06-17" version="1">MPVMAAAFLPRGGAGGVVEGMLAEGEQSEMSPKGSKEQRNLRVQDGGSRREGRQKQKPAGDFGMFQGVENQIHREEKKHECSVCGKSFGRRSTLTRHQRVHTGEKPYTCLECGKSFIHSTALILHRRTHTGEKPYICSECGKSFSERGHLTRHQRTHTGEKPYICSECGKSFSERGKLTRHRRTHTGEKPYKCLECGKSYSHCGALTVHQRSHTGEKPYACSECGKSFSRCGQLTLHQRSHTGEKSYTCLECGRSFRRCDQLTSHQRTHTGEKPYTCSECGKSFSQCGQLTLHQRSHTGEKPYTCLECGRSFRRCDQLTSHQRTHTGEKPYTCSECGKSFSQISNLKLHRRTHTGEKPYKCLECGKSYSHCGALTLHQRFHTGEKPYTCSECGRSFSQSSALKSHQRTHTGEKPHTCSECGKSFSHIGALTLHQRFHTGEKTVYMFRVWKELQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HRR8</accession>
    <name>A0A670HRR8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transient receptor potential cation channel subfamily M member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TRPM8</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HRR8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002627.1">
        <property type="protein sequence ID" value="ENSPMRP00000002469.1"/>
        <property type="gene ID" value="ENSPMRG00000001779.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160270"/>
    <dbReference type="OMA" id="CCKNESK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099604">
        <property type="term" value="F:ligand-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF9">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="715"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="943"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1013"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="369"/>
        </location>
    </feature>
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        <location>
            <begin position="436"/>
            <end position="500"/>
        </location>
    </feature>
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        <location>
            <begin position="538"/>
            <end position="662"/>
        </location>
    </feature>
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        <location>
            <begin position="731"/>
            <end position="977"/>
        </location>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002469.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1092" mass="126164" checksum="2FF544E3F1F80360" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HSR3</accession>
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        </submittedName>
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        <name evidence="2" type="primary">REEP2</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028718565.1"/>
    </dbReference>
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        <property type="gene ID" value="ENSPMRG00000001997.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114591478"/>
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    <dbReference type="GeneTree" id="ENSGT00940000160001"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:sensory perception of bitter taste"/>
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        <property type="project" value="Ensembl"/>
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            <end position="305"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="305" mass="32855" checksum="6D6758BA4739105F" modified="2020-06-17" version="1">MTRRPSSNRRTDAEPTAMRPLLFFPPTGAAGSSPLRSRGGAALAAGTCPLTALSPFLAGAAAKSQLASPRRPPEEPRPRHGVLDHLPAGGAGFRHLVPSILLLQSCEDEKCEGICQMDDVLDCVCFLHHSRDTHRHHSLLEIDEYISQARDKSYETMMRVGKRGLNLAANAAVTAAAKGQGVLSEKLRSFSMQDLTLIRDDDTVHLRSPEPRMRTSATGHLETVDDSGASCYSSSEEMTLSQRHNGAQSDARTDPSDDDTGDKVPKRTQSLKAPKKVTKTEPPQKTVKARPKKKVTGSSAAGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HT37</accession>
    <name>A0A670HT37_PODMU</name>
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        <submittedName>
            <fullName evidence="4">SAP domain containing ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SARNP</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HT37"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002897.1">
        <property type="protein sequence ID" value="ENSPMRP00000002711.1"/>
        <property type="gene ID" value="ENSPMRG00000001950.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002944"/>
    <dbReference type="OMA" id="NEDPIEL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000346">
        <property type="term" value="C:transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
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    </dbReference>
    <dbReference type="Pfam" id="PF02037">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="209" mass="23386" checksum="347EDDA0D11088B6" modified="2020-06-17" version="1">VLFPPLSLHLAELKQECLARGLEAKGNKQDLINRLQAYLEQHGRFLHCILSTLYQDPSNKIEQSPAKSVNLSSSRGAEKKVVKIASEIPQTERMQKRAERFNVPVSLESKKAARAKACFKYDNLKWFLFPISGLATESKTTVNIDKLKERAQRFGLNVSTASKKTEDDEKLKKRKERFGIVTSSAGAATTEDAEVTCQTKADKGHILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTI0</accession>
    <name>A0A670HTI0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HTI0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003050.1">
        <property type="protein sequence ID" value="ENSPMRP00000002846.1"/>
        <property type="gene ID" value="ENSPMRG00000002054.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000173590"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511:SF1">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="104" mass="11406" checksum="6B1270C0AEE1AD0D" modified="2025-10-08" version="2">MSLACSGAGNKQMLPSSIMFHSDQAQLKADVIEQDTQEWQSNPSFAGLERVGGADLSYIKEDDTSACASLVVLSYPDLENRHRQTRPCSCFGTTIPIIPDHWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HU72</accession>
    <name>A0A670HU72_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA cross-link repair 1A protein</fullName>
            <ecNumber evidence="4">3.5.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SNM1 homolog A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DCLRE1A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028586054.1">
        <property type="nucleotide sequence ID" value="XM_028730221.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028586055.1">
        <property type="nucleotide sequence ID" value="XM_028730222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HU72"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003488.1">
        <property type="protein sequence ID" value="ENSPMRP00000003253.1"/>
        <property type="gene ID" value="ENSPMRG00000002302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597472"/>
    <dbReference type="KEGG" id="pmua:114597472"/>
    <dbReference type="CTD" id="9937"/>
    <dbReference type="GeneTree" id="ENSGT00940000158766"/>
    <dbReference type="OMA" id="FRFPIYC"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000001">
        <property type="entry name" value="DNA cross-link repair 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000010">
        <property type="entry name" value="DNA cross-link repair 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="654"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="590"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="997" mass="110934" checksum="3FFD2E78B12555EE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUG9</accession>
    <name>A0A670HUG9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dual specificity protein phosphatase 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114597047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028584939.1">
        <property type="nucleotide sequence ID" value="XM_028729106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HUG9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003091.1">
        <property type="protein sequence ID" value="ENSPMRP00000002885.1"/>
        <property type="gene ID" value="ENSPMRG00000002080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597047"/>
    <dbReference type="KEGG" id="pmua:114597047"/>
    <dbReference type="GeneTree" id="ENSGT00940000162682"/>
    <dbReference type="OMA" id="IYPNRHF"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033549">
        <property type="term" value="F:MAP kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14515">
        <property type="entry name" value="DUSP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682">
        <property type="entry name" value="AGAP008228-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682:SF16">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="83"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="151"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR620405-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="238" mass="26898" checksum="8CEDA9EB82FCCF90" modified="2020-06-17" version="1">MGMGRGRKRDISQKAHLLLPVKCRKVTGAHWGSATTMYHRMTTDDPFPKTTASFCKMNSRRSASPSVQELEHVMDSCRMELNEIDEVWPNLYIGNITAAHNKEELRKRGITHILNAAHAAWGSKGNPTFYGPEFHYYGIAAEDSPDFDLSVHFRPASEFITKALSVPNGKILVHCILGRSRSAALVLAYLMICQNFSLADAVRKVLQNRAISPNRGFLKQLQDLDLELRYKIRLCRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXB1</accession>
    <name>A0A670HXB1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thyroxine-binding globulin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Serpin A7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">T4-binding globulin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Major thyroid hormone transport protein in serum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HXB1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004500.1">
        <property type="protein sequence ID" value="ENSPMRP00000004216.1"/>
        <property type="gene ID" value="ENSPMRG00000002884.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160877"/>
    <dbReference type="OMA" id="IHSNSYC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000001">
        <property type="entry name" value="Serine protease inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.310.10:FF:000001">
        <property type="entry name" value="Serpin family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.310.10">
        <property type="entry name" value="Serpins superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF375">
        <property type="entry name" value="THYROXINE-BINDING GLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Serpin" evidence="11">
        <location>
            <begin position="33"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="380" mass="42855" checksum="DE261165DB7BBD1D" modified="2020-06-17" version="1">SPTHLTECLLWGRKGKENTPNQVLVNSNSDFAFKFFRQVSSNGGNRGSPFKKNIVFSPMCISTAFAMLALGARANTLDQILRGLDFKPSEIQERMIHEGFHNLIYSLSNGGSGLQMEMGNCLFVQNELHPQPQFLRELRNIYGGEIYMENFKNTAVTEEHINQYVKMKTHGKISKLVDGVDPITEILLVSYIYMKGKTTKWKKPFDPKYTTEQNFYVDPYTIVKVPMMFQMGMFETGYDNERLCTVLKLPYKGHAASYFILPDKGTDGEGDVYLPRCLASGELNLKDIMYTMGVVDVFTDRADLSGITGQPQHRLSGALHKAMMMIDERGTEAAAASSMDMVPMSMPTIVKFNEPFITMVVDEPTNSILFMAKIFNPTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXK6</accession>
    <name>A0A670HXK6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPIL6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A670HXK6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004736.1">
        <property type="protein sequence ID" value="ENSPMRP00000004439.1"/>
        <property type="gene ID" value="ENSPMRG00000003033.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159634"/>
    <dbReference type="OMA" id="ECKIINC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000048">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="93"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="259" mass="29891" checksum="8C3E17B001948944" modified="2020-06-17" version="1">NKIAEPKVLPLLQFAWDEYLQEKKKELKGETWEYPSNVMCFIDGQLVGDEKQLLQWAYDVWDYEDFKPVALYEAITQDFLTKYMRNKQHVFVYFEISIQAEPKGKLLFELYSDICPRTCKNFQYLCSGEKKKSMSGLPLTYRDSIFHRLVKNGWIQGGDIRGGRGTGGESIYGPFFEDESFAVLHDKRGVLGMANKGRHSNASQFYITLQPAPYLNEKYVAFGQLIEGSEVLRELEAVETFNERPVVECKIVNCGVFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXM5</accession>
    <name>A0A670HXM5_PODMU</name>
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        <submittedName>
            <fullName evidence="10">RNA binding motif protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RBM20</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028586142.1">
        <property type="nucleotide sequence ID" value="XM_028730309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HXM5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004750.1">
        <property type="protein sequence ID" value="ENSPMRP00000004453.1"/>
        <property type="gene ID" value="ENSPMRG00000003046.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmua:114597489"/>
    <dbReference type="CTD" id="282996"/>
    <dbReference type="GeneTree" id="ENSGT01030000234642"/>
    <dbReference type="OMA" id="PTRADWG"/>
    <dbReference type="OrthoDB" id="8949749at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034790">
        <property type="entry name" value="RBM20_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="528"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="1162"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="752"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="963"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1206"/>
            <end position="1228"/>
        </location>
    </feature>
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        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
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        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
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        <location>
            <begin position="646"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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            <end position="784"/>
        </location>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1228" mass="137100" checksum="2E9A1A624417BFE6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZY9</accession>
    <name>A0A670HZY9_PODMU</name>
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        <submittedName>
            <fullName evidence="8">Glucosidase alpha, neutral C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GANC</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
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        <property type="gene ID" value="ENSPMRG00000002934.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000159230"/>
    <dbReference type="OMA" id="MHNVYGH"/>
    <dbReference type="Proteomes" id="UP000472272">
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        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
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        <property type="entry name" value="Glyco_hydro_b"/>
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        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF60">
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    </dbReference>
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        <property type="entry name" value="Gal_mutarotas_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="293"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="630"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="848" mass="96950" checksum="2D74B07D69203F35" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1Z1</accession>
    <name>A0A670I1Z1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 T</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">E2 ubiquitin-conjugating enzyme T</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein T</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase T</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UBE2T</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A670I1Z1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000005500.1"/>
        <property type="gene ID" value="ENSPMRG00000003750.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein K11-linked ubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044314">
        <property type="term" value="P:protein K27-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein K29-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="69"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="298" mass="33353" checksum="E32CA1C17F40D888" modified="2020-06-17" version="1">MRGDVFARRPGADSGLVWAEVHQGQLPALWRGGEVALLSACLYSFVKALETYQNAKVEASRAHLFTAMQRASRLKRELHLLTTQPPPGITCWQNGSRIDDLQAQMLGSADTPYEKGIFNLEVVVPERYPFEPPKIRFLTPIYHPNIDSAGRICLDVLRLPPKGAWRPSLNIATLLTSIQILMNEPNPDDPLMADISSEYKYNKQTFLKNARQWTEKYASQTTMYGSKSADGPHPPCICMRGGIHQQRRRSFGKIIPTLETTDEENHQSAANPPKDSHISQKRKGSSISGLSKRPCSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I212</accession>
    <name>A0A670I212_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ligand dependent nuclear receptor interacting factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LRIF1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028590512.1">
        <property type="nucleotide sequence ID" value="XM_028734679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I212"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005881.1">
        <property type="protein sequence ID" value="ENSPMRP00000005525.1"/>
        <property type="gene ID" value="ENSPMRG00000003766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599435"/>
    <dbReference type="KEGG" id="pmua:114599435"/>
    <dbReference type="CTD" id="55791"/>
    <dbReference type="GeneTree" id="ENSGT00390000017353"/>
    <dbReference type="OMA" id="ERNDKNH"/>
    <dbReference type="OrthoDB" id="9944055at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:dosage compensation by inactivation of X chromosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026191">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16131">
        <property type="entry name" value="LIGAND-DEPENDENT NUCLEAR RECEPTOR-INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16131:SF2">
        <property type="entry name" value="LIGAND-DEPENDENT NUCLEAR RECEPTOR-INTERACTING FACTOR 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="765" mass="83274" checksum="4BE80530180C8858" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I2T5</accession>
    <name>A0A670I2T5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TLR adaptor interacting with endolysosomal SLC15A4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TASL</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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</entry>
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    <accession>A0A670I556</accession>
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        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I556"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="6019" checksum="9FAF58B2D04B5033" modified="2020-06-17" version="1">MQNDAGEFVDLYVPRKCSRHPHPSNRITGAKFIQMNISEVDKVTGRVNGQFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5C5</accession>
    <name>A0A670I5C5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Death-inducer obliterator 1</fullName>
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        <alternativeName>
            <fullName evidence="16">Death-associated transcription factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DIDO1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts specifically (via PHD-type zinc finger) with histone H3 that is trimethylated at 'Lys-4' (H3K4me3), histone phosphorylation at 'Thr-3' or 'Thr-6' disrupts this binding and promotes translocation of DIDO1 from chromatin to the mitotic spindle during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000007397.1">
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        <property type="gene ID" value="ENSPMRG00000004709.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
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        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:apoptotic signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Death-inducer obliterator 1"/>
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        <property type="entry name" value="Death-inducer obliterator 1"/>
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        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIDO1_PHD"/>
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        <property type="entry name" value="SPOC_C"/>
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        <property type="entry name" value="TFIIS_cen_dom"/>
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        <property type="entry name" value="TFIIS_cen_dom_sf"/>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF13">
        <property type="entry name" value="DEATH-INDUCER OBLITERATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="9">Cytoplasmic polyadenylation element binding protein 3</fullName>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="479" mass="52481" checksum="0E72DBDCA1574F9B" modified="2020-06-17" version="1">MEFSEEQLKKWLSKYKFRDLTIEELKSIHESYPNTTFAMNTYTFKDGSQKDLLNCSGTVPVKYQGNSYNIPIFLWILDSHPFTPPICFLKPTANMGISVGKHVDARGRIYLPYLQNWSHPQSMIIGLLKEMSAKFEEELPLFSVSSSDAARQSELLSYIAKITEGEDNIQSKGEGKKNDGGFNKVTVIGAGDLGLACALAISAKGVADRVVVLDCSEGTMKGAAMDLEIFALPNVEISRDFSASAGSKLVVLTVNSLGNAQSYLDVVQSNVELFRGIIPSVAHYSQQSVLLVASQPVEIMTYVSWKMSGFPKSRVIGIGCNLDSARFQYIIANLLKAQIRGKDNWIIGEQGENKVAAWSASNSVTSHQDEDIANQNAQHLLANRAMEVLKGRGQKSWSVGLSIADLADSILNDKRKVHSISTMVKGCYNINSEVFLSVPCVLGISGVTEVIKLLDKGTVVQELQSTAASIHDLQQQLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8T1</accession>
    <name>A0A670I8T1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pleckstrin homology-like domain family A member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Imprinted in placenta and liver protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PHLDA2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I8T1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008664.1">
        <property type="protein sequence ID" value="ENSPMRP00000008104.1"/>
        <property type="gene ID" value="ENSPMRG00000005487.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000039564"/>
    <dbReference type="OMA" id="CWHAEIT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042832">
        <property type="entry name" value="PHLA1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478:SF8">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="130" mass="14225" checksum="C2325B84361F6131" modified="2020-06-17" version="1">MGAGGGGVIREGELEKRSDSLFQLWKKKAVVLSKDSLSLFSPEAGKARGGGGKELRFGSIQKVDCVERTGKYVYFTIVTTDRKEIDFRCPGESCWNASITMALIDFQNKRAIEDFKSRQEAADGTCSASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IAT8</accession>
    <name>A0A670IAT8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMEM100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028567121.1">
        <property type="nucleotide sequence ID" value="XM_028711288.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028567125.1">
        <property type="nucleotide sequence ID" value="XM_028711292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IAT8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009609.1">
        <property type="protein sequence ID" value="ENSPMRP00000008995.1"/>
        <property type="gene ID" value="ENSPMRG00000006053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587232"/>
    <dbReference type="KEGG" id="pmua:114587232"/>
    <dbReference type="CTD" id="55273"/>
    <dbReference type="GeneTree" id="ENSGT00940000154322"/>
    <dbReference type="OMA" id="PMTMEKS"/>
    <dbReference type="OrthoDB" id="9893370at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060842">
        <property type="term" value="P:arterial endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003198">
        <property type="term" value="P:epithelial to mesenchymal transition involved in endocardial cushion formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045603">
        <property type="term" value="P:positive regulation of endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001214">
        <property type="term" value="P:positive regulation of vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051930">
        <property type="term" value="P:regulation of sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032536">
        <property type="entry name" value="TMEM100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16100">
        <property type="entry name" value="PHOSPHOINOSITIDE-INTERACTING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16100:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16311">
        <property type="entry name" value="TMEM100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="134" mass="14302" checksum="F0DF25A9B3CAE4A4" modified="2020-06-17" version="1">MTDEPIKEILGGSKCPQCATLEKCNNNDCRVTAVPLVSECRLTAATGGAELSCYRCTIPFGVVILIAGVVVTAVAYSFNSHGSIISVLGLVILSSGLLLLALSALCWKIRQKSKKTKRRESQTTLVANQRSLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBF0</accession>
    <name>A0A670IBF0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetylserotonin O-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Hydroxyindole O-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.4" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A670IBF0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009578.1">
        <property type="protein sequence ID" value="ENSPMRP00000008964.1"/>
        <property type="gene ID" value="ENSPMRG00000006023.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161561"/>
    <dbReference type="OMA" id="IKETGPQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017096">
        <property type="term" value="F:acetylserotonin O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030187">
        <property type="term" value="P:melatonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000358">
        <property type="entry name" value="Acetylserotonin O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000146">
        <property type="entry name" value="Acetylserotonin O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0471">Melatonin biosynthesis</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="13">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="12">
        <location>
            <begin position="121"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="347" mass="39137" checksum="E557C5347FD87EE1" modified="2020-06-17" version="1">MSATEEAEALKMLFRNQNAFLIPKVKIMFTASDLGVFDPLMESKEPLTSVSIAERLGTSPFGMERLLDACVGYKFLQVERKDNQTLYGNTNIANLYLGKRSPKTQYYSLKLNAEFVYMRAQHLADSVREGEAQTYRLSDSSTKKFYEAMYRSESSLREFMEYMHEMWSLCGRDVLNAFDLSNFPLVCDLGGCSGALAKEYISLYPNSTVTILDLPEVVETGKKHFVSSEEHRITFHKGDFFKDPIPEADLYILARILHSFTDENCVQLLTRLNKACKPGGGVLVVEIVLNEDRTGPVEAHIYGLVMLLCTQGKERTLSEYNGLLSAAGFKEIQQKKTGLFDAILGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBT5</accession>
    <name>A0A670IBT5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TGFB induced factor homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TGIF1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TALE/TGIF homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IBT5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009771.1">
        <property type="protein sequence ID" value="ENSPMRP00000009153.1"/>
        <property type="gene ID" value="ENSPMRG00000006145.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155230"/>
    <dbReference type="OMA" id="CSAGPNP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035881">
        <property type="term" value="P:amacrine cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048144">
        <property type="term" value="P:fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048387">
        <property type="term" value="P:negative regulation of retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038092">
        <property type="term" value="P:nodal signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902871">
        <property type="term" value="P:positive regulation of amacrine cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048146">
        <property type="term" value="P:positive regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010470">
        <property type="term" value="P:regulation of gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000059">
        <property type="entry name" value="TGFB-induced factor homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="267" mass="29332" checksum="9B8CDC504574EFE2" modified="2020-06-17" version="1">VKSRKYAAVAISGSETEDDDSMDVPLDLSSSASSVKRRRRGNLPKESVQILRDWLYEHRFNAYPSEQEKALLSRQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGTKMADGSPVEFSIGTKNCIPLIESSFLSGSTGPNKTCKSSSLGSVLARPSVICHTTVTALKDAPFHFGQPGGTGQTPDDLQRASPTNFTDNAHLYHEDVSKLGPGTNAQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IBV1</accession>
    <name>A0A670IBV1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COIL</name>
    </gene>
    <organism evidence="5 6">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="While G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:12670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.43" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028592346.1">
        <property type="nucleotide sequence ID" value="XM_028736513.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592347.1">
        <property type="nucleotide sequence ID" value="XM_028736514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IDS9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010489.1">
        <property type="protein sequence ID" value="ENSPMRP00000009843.1"/>
        <property type="gene ID" value="ENSPMRG00000006586.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600424"/>
    <dbReference type="CTD" id="54704"/>
    <dbReference type="GeneTree" id="ENSGT00940000156368"/>
    <dbReference type="OMA" id="DVRTPPY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010510">
        <property type="term" value="P:regulation of pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF627">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 20" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="21">
        <location>
            <begin position="134"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="561" mass="63373" checksum="58E7EA9A46A7FB22" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDW6</accession>
    <name>A0A670IDW6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 64</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM64</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028592393.1">
        <property type="nucleotide sequence ID" value="XM_028736560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IDW6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010783.1">
        <property type="protein sequence ID" value="ENSPMRP00000010120.1"/>
        <property type="gene ID" value="ENSPMRG00000006757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600442"/>
    <dbReference type="KEGG" id="pmua:114600442"/>
    <dbReference type="CTD" id="169200"/>
    <dbReference type="GeneTree" id="ENSGT00390000007813"/>
    <dbReference type="OMA" id="QNGLYHC"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030316">
        <property type="term" value="P:osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045780">
        <property type="term" value="P:positive regulation of bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045672">
        <property type="term" value="P:positive regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053069">
        <property type="entry name" value="TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46593">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46593:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="2">
        <location>
            <begin position="174"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="375" mass="40167" checksum="B846EBFC19016611" modified="2020-06-17" version="1">MWSLGATALQLLSRAAKHAFAQGARQDLNRWLPRQGAATAAEPGEAPGRGGASEGLFWGEQNGLHHYPSPSPPHHHPSVEPSVEILLCQLPEVGPGLSEGRTWRCSGCLLGTCWCKSCLSACFLAALCFASLALVRQYLRDLMLWAESLDSLAGVLLFTVGFIVVSFPCGWGYILLNVAAGYLYGFVLGMGLMVLGVLIGTFISHVVCRKLLAEWVLARIQGSEKLAAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSITDLSLPNYLMASSIGLLPTQLLNSYLGTTLRTMEDVIAEQSVSGYFIFSLQIVISIGLMFYVVHRAQVELNAAIVACEMEMKTSLVKSSLPSNSNSSFCSKRTLAFSGGGINIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IF65</accession>
    <name>A0A670IF65_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
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        <property type="entry name" value="Formin-like protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF5">
        <property type="entry name" value="FORMIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="612"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1022"/>
        </location>
    </feature>
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        <location>
            <begin position="381"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="891"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1089" mass="123628" checksum="669810BFDF682C80" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGT0</accession>
    <name>A0A670IGT0_PODMU</name>
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        <recommendedName>
            <fullName evidence="4">L1 transposable element RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="entry name" value="L1 transposable element, C-terminal domain"/>
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        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="28022" checksum="560BBCFCC71390A6" modified="2020-06-17" version="1">MDKKIDATVNELKGQLKDVSKRTQNLEEGMKKTRVEMREMKKDEERIWAGMSEINKTQEEVWDAISMNELRQREVNLRLRLVPELQGENIKEKLIKEIAQWMEMDIEEVTKSVQSAFRLKTRSAKARKLPGDCLVTFKDREMRNQILQKNREKRLNIEGNYIIIFKDISIRLLKRRDPYKPTVQILEKNNIELRWEYPEGISFVYKSKRHRLTSLEELGKFLRKYKEQNFTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGT6</accession>
    <name>A0A670IGT6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="21">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">RPAP2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20 21">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="21"/>
    <dbReference type="RefSeq" id="XP_028588621.1">
        <property type="nucleotide sequence ID" value="XM_028732788.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028588622.1">
        <property type="nucleotide sequence ID" value="XM_028732789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IGT6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011818.1">
        <property type="protein sequence ID" value="ENSPMRP00000011063.1"/>
        <property type="gene ID" value="ENSPMRG00000007382.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000011833.1">
        <property type="protein sequence ID" value="ENSPMRP00000011078.1"/>
        <property type="gene ID" value="ENSPMRG00000007382.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114598761"/>
    <dbReference type="KEGG" id="pmua:114598761"/>
    <dbReference type="CTD" id="79871"/>
    <dbReference type="GeneTree" id="ENSGT00390000017965"/>
    <dbReference type="OMA" id="YPICQNK"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036499">
        <property type="term" value="P:PERK-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009301">
        <property type="term" value="P:snRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.820:FF:000001">
        <property type="entry name" value="RNA polymerase II subunit B1 CTD phosphatase Rpap2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 21" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="23">
        <location>
            <begin position="71"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <location>
            <begin position="366"/>
            <end position="388"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="424" mass="47019" checksum="8DBF4FE461301012" modified="2020-06-17" version="1">MPIPLTVTRQLLQSWGAHHTYNKWIQVAEMVAFSANRTNCAVCTLAPVNALGGMPLLPVPWNESLVTTPLVAFQPLGNHSSLWNHSVPFQVHRITGCLCVNKSNDASDSQTYVGTSHCDRTFPAPTNMPESETGTFTGSNLTACLARLLRGTISAHGQDVYWVCGRKAYHALPRGWYGVCFPAYLIPPMWIPDQIPSAPPRRRRSADLATLAGGSSQNWGKNQWPPERILAHYAPASWNRREKISGARGPIYNLNRVIRLQAVVEIVANTTATALRLIATQLDETRNAFLSVRLALDFLLAQHGGFCAALNLTGGTCCFNISDHGEAIRNLAAGLETVAHIPTQTWEGWDMSWLDWLPNLGWVKGLFLLLLGPLFILLIFCFSVPCLLQSLHTMTCNMISRMLRPQIIALTREYQPVPSWDEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INP8</accession>
    <name>A0A670INP8_PODMU</name>
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        <submittedName>
            <fullName evidence="2">Transmembrane protein 222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670INP8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014716.1">
        <property type="protein sequence ID" value="ENSPMRP00000013773.1"/>
        <property type="gene ID" value="ENSPMRG00000009236.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="180" mass="20065" checksum="A349273D5E0BB93C" modified="2020-06-17" version="1">MKQFHGGVSVGVGGGAGGAGLDPERCRFPYCVVWTPIPVLTWLFPIIGHMGICTSAGVIRDFAGPYYVSVSRSLFLYWKLDPSKVYSCGPNAWDTAVHDASEEYKHRMHNLCCDNCHSHVALALNLMRYDNSTSWNMVKLCFLSLLYGKYVSIGGFVKTWLPFILFLGIILIVSLTLHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IP91</accession>
    <name>A0A670IP91_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="10">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EIF2A</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IP91"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014398.1">
        <property type="protein sequence ID" value="ENSPMRP00000013481.1"/>
        <property type="gene ID" value="ENSPMRG00000009022.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111053"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000149">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000976">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="12">
        <location>
            <begin position="216"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="432"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="590" mass="65075" checksum="E76D17D8379A0813" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IR02</accession>
    <name>A0A670IR02_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NF-kappa-B inhibitor alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">I-kappa-B-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NFKBIA</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Bellati A."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="13">Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.</text>
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        <location>
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</entry>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Bellati A."/>
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                <person name="Pauperio F."/>
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                <person name="While G.M."/>
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                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
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        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IV96</accession>
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    <gene>
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    <organism evidence="23 24">
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        <name type="synonym">Lacerta muralis</name>
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    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
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                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
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                <person name="Font E."/>
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            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
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        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="19">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028603216.1">
        <property type="nucleotide sequence ID" value="XM_028747383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IV96"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016925.1">
        <property type="protein sequence ID" value="ENSPMRP00000015850.1"/>
        <property type="gene ID" value="ENSPMRG00000010579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605803"/>
    <dbReference type="KEGG" id="pmua:114605803"/>
    <dbReference type="CTD" id="1407"/>
    <dbReference type="GeneTree" id="ENSGT00940000155455"/>
    <dbReference type="OMA" id="YTVFTPY"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000001">
        <property type="entry name" value="Cryptochrome 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.80:FF:000002">
        <property type="entry name" value="cryptochrome-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.80:FF:000003">
        <property type="entry name" value="cryptochrome-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000099">
        <property type="entry name" value="cryptochrome-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF16">
        <property type="entry name" value="CRYPTOCHROME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="13" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 19" id="KW-0274">FAD</keyword>
    <keyword evidence="10 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="22">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="289"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="387"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="20">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="20">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="20">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="622" mass="69988" checksum="06248A90798BCCCE" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVE7</accession>
    <name>A0A670IVE7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IVE7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017275.1">
        <property type="protein sequence ID" value="ENSPMRP00000016183.1"/>
        <property type="gene ID" value="ENSPMRG00000010817.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="MIATMSH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="406" mass="46729" checksum="6F2D5A9C8DCF5B37" modified="2020-06-17" version="1">MIATMSHSEQGQAAISSANTIKRDQIANMRWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRTGYGTTDWFKIGKGVRQGCILSPCLFNLPVYAEYIMRKAGLDESQAGIKIAGRNINNLRYADGTTLMAESEEELKNLLMRVKEESAKYGLRLNVKKTKIMATGPITSWQVEGEEMEAVRDFTFLGSMITADGDSSHEIKRRLLLGRRAMTGLDSILRSRDVTLPTKVHIVKAMVFPVVMYGSESWTIKKADHRRIDAFELWCWRRLLRVPWTARRSNASILKEISPECSLEGQIVKLRLQYFGHLMRREDSLEKTLMLGKMEGTRRRGRQRTRWLDSVFEVTSMSLTKLREVVEDRGAWRAMVHGVTKSRTRLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IYB6</accession>
    <name>A0A670IYB6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Netrin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Netrin-4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114591761</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">May form a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028575069.1">
        <property type="nucleotide sequence ID" value="XM_028719236.1"/>
    </dbReference>
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    <sequence length="645" mass="72195" checksum="AEDE06B1146BC9D4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZ46</accession>
    <name>A0A670IZ46_PODMU</name>
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        <recommendedName>
            <fullName evidence="14">Actin-related protein 6</fullName>
        </recommendedName>
    </protein>
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        <name evidence="15" type="primary">ACTR6</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for formation and/or maintenance of proper nucleolar structure and function. Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. Interacts with CBX1, CBX3 and CBX5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="396" mass="45792" checksum="887CC9965A9CD81F" modified="2020-06-17" version="1">MATLVLDNGAYNAKIGYSHAHVSVIPNCQFRSKTARLKTFTANQLDEIKDPSGLFYILPFQKGYLVNWDVQRQVWDYLYGKEMYQVDFVDTNIIITEPYFNFSSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFFKDMETAKLKGEENTVMLDYVLPDFSTIKKGFCKPREEMVLSGKYKTGEQILRLTNERFAVPEILFHPSDIGIQEMGIPEAIVYSIQNLPEEMQPHFFKNIVLTGGNTHLPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYSWEGGKLISENDDFEDMVVTREDYEENGHSICEEKFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J0F1</accession>
    <name>A0A670J0F1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiotic kinetochore factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MEIKIN</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028573837.1">
        <property type="nucleotide sequence ID" value="XM_028718004.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028573838.1">
        <property type="nucleotide sequence ID" value="XM_028718005.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028573839.1">
        <property type="nucleotide sequence ID" value="XM_028718006.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028573840.1">
        <property type="nucleotide sequence ID" value="XM_028718007.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028573841.1">
        <property type="nucleotide sequence ID" value="XM_028718008.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028573842.1">
        <property type="nucleotide sequence ID" value="XM_028718009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J0F1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018754.1">
        <property type="protein sequence ID" value="ENSPMRP00000017616.1"/>
        <property type="gene ID" value="ENSPMRG00000011627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591260"/>
    <dbReference type="KEGG" id="pmua:114591260"/>
    <dbReference type="CTD" id="728637"/>
    <dbReference type="GeneTree" id="ENSGT00390000016270"/>
    <dbReference type="OMA" id="NEFPANT"/>
    <dbReference type="OrthoDB" id="8443315at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016321">
        <property type="term" value="P:female meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007060">
        <property type="term" value="P:male meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010789">
        <property type="term" value="P:meiotic sister chromatid cohesion involved in meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034545">
        <property type="entry name" value="Meikin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38006">
        <property type="entry name" value="MEIOSIS-SPECIFIC KINETOCHORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38006:SF1">
        <property type="entry name" value="MEIOSIS-SPECIFIC KINETOCHORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="428" mass="46316" checksum="E0D308F00DBCDF20" modified="2020-06-17" version="1">MDWVKLRSYSRKRRAQQNVHCASPIPAVAASAAVGARNAKAKGSRLRLDLLSGPRQEPHVRRQIGNAITKALPKIQEASGVTQMDCLSVEQSTELNENENRNMEVNKSINKMGTAVLKDSLHLSSASKESPRYSETTSGMTLPTGVSHFLLQCLDEESSLCSNTESSDGASTYSSPEIFRDENTLEKSSTGPEECLGHRNSTLLDTSKAINIDKMPHVPNLSQILETTLGKKDQSITRLSKQKSRSELTGVSAVVAGKQVCKILPAKEKTPELQSFGASLLPQKQTKKTKDQQPRKMKCTKRVLFSSSSSSPYVLGPAKFCGIAAETLGSAQPGTGMLDSSSVHKVSLGEASLPSTSRSNVNSKEVIPASLSPESVIHQCLRNPPEICCIIKASPGSRPLKVLQHPLKRKREFPPPGATEDVITSSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J1V7</accession>
    <name>A0A670J1V7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J1V7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019329.1">
        <property type="protein sequence ID" value="ENSPMRP00000018170.1"/>
        <property type="gene ID" value="ENSPMRG00000011880.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162710"/>
    <dbReference type="OMA" id="ELFCQQH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000004">
        <property type="entry name" value="Pepsin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF13">
        <property type="entry name" value="CHYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025585027" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="70"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="366" mass="40799" checksum="D7D7E9CB34FE7F1B" modified="2020-06-17" version="1">YDGMVILSLLLCLELWSGKTGLRDTLKEKNLLENLLQKYRYDIGIKYNSDISNAAQVAEEPLLNSFETEYYGTIYIGTPPQKFTVVFDTGSSTLWVPSLYCSSQACQTHHRFDPRKSSTFQGTGQPFSIKYGKGSMEGIFGLDTVKISDLTISDMEFGLSTSESEDPFSRTKYDGILGLNPWKKSSFFENLMKKGLLEKDEFSVYLSGKTDGSMIIFGGIDQSYFTGPINWIPATYRKFKIEVDSILVYGQAIACRDGCEALLDTGTSFLLGPASEISQIQQAIGVTTGERGENLHNMPDVVFVINGIQYPLTPQAYTHKDDDHCKSGFSSGSKDYDHLILGDMFLREYYSIFDRGNNQVGLAKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J2V2</accession>
    <name>A0A670J2V2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670J2V2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000019742.1">
        <property type="protein sequence ID" value="ENSPMRP00000018576.1"/>
        <property type="gene ID" value="ENSPMRG00000012195.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286929"/>
    <dbReference type="OMA" id="TECEVNI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="338" mass="39050" checksum="7F9AD96DDF0ED42E" modified="2020-06-17" version="1">MHWIMEKAREFQKDIYFCFIDYAKAFDCVDHSKLWQVLKEMGVPDHLICLLRNLYVGQEATVRSGYGTTDWFKIGKGVWQGCILSPCLFNLYAEFIMRKAGLDESQAGIKITGRNINNLRYADDTTLMAESEEELKNLLMRVKEESAKYGLKLNIKKMKIMATGPITSWQIEGGEMEAVRDFTFLGSMINADGDSSHEIKRRLLLGRKAMANLDSILKSRDITLPTKVRIVKAMVFPVVMYGSESWTIKTADRRRIDDFELWCWRRLLRVPWTARSNLSILQEISPECSLEGQILKLRLQYFGHLMRREDSLEKTLMLGTLMHKEKGTTEDEMVGQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3K3</accession>
    <name>A0A670J3K3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FGB</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028600204.1">
        <property type="nucleotide sequence ID" value="XM_028744371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J3K3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020014.1">
        <property type="protein sequence ID" value="ENSPMRP00000018841.1"/>
        <property type="gene ID" value="ENSPMRG00000012327.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604333"/>
    <dbReference type="KEGG" id="pmua:114604333"/>
    <dbReference type="CTD" id="2244"/>
    <dbReference type="GeneTree" id="ENSGT00940000158122"/>
    <dbReference type="OMA" id="GCIHADP"/>
    <dbReference type="OrthoDB" id="9930906at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031091">
        <property type="term" value="C:platelet alpha granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072377">
        <property type="term" value="P:blood coagulation, common pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043152">
        <property type="term" value="P:induction of bacterial agglutination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000352">
        <property type="term" value="P:negative regulation of endothelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031639">
        <property type="term" value="P:plasminogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090277">
        <property type="term" value="P:positive regulation of peptide hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045907">
        <property type="term" value="P:positive regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051592">
        <property type="term" value="P:response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.50:FF:000002">
        <property type="entry name" value="Fibrinogen beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000006">
        <property type="entry name" value="Fibrinogen beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.530.10:FF:000004">
        <property type="entry name" value="Fibrinogen beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012290">
        <property type="entry name" value="Fibrinogen_a/b/g_coil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08702">
        <property type="entry name" value="Fib_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01212">
        <property type="entry name" value="Fib_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58010">
        <property type="entry name" value="Fibrinogen coiled-coil and central regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025684359" description="Fibrinogen beta chain" evidence="12">
        <location>
            <begin position="27"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="13">
        <location>
            <begin position="241"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="498" mass="56286" checksum="CF7BE74EFB6293A2" modified="2020-06-17" version="1">MLTQSKIMKLLLLFLLSVVVVVKSQAAVDYDDEEEVATTAAPVDGDGVDARGHRPLNKKREPYPTLRPAPLPPSSGFRYRARPTKPPAAGRKREQVAFPDHGGCKHMSEELGVLCPTGCELRTALLKQERTVKPTVQDLTDKVQKLEQSTSTIYSYTHLLDERLAKKQKQVLDNQNVISQYNKEVEEHYTFIKDNLDNNIPTNLRLLRSVVDSLQKKIQELQKTVTSQLQDCRTPCTVSCNIPVVSGKECEDIIRKGGETSEMYLVQPDPFFKPYRVYCDMKTDNGGWLLIQNRQDGSVNFGRPWDSYKKGFGNVASSGGKNYCDTPGEYWLGNDKISQLTKMGPTELLIELEDWNGDKVKAHYGGFSIQGEANKYQLSVSNYRGTAGNALLEGASQLYGENRTMTIHNSMFFSTFDRDNDGWPNPDPKKQCSKEDGGGWWYNRCHSANPNGRYYWGGHYTSEMAKHGTDDGMVWMNWKGSWHSLKKASMKIRPIIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J503</accession>
    <name>A0A670J503_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">RPS3A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028599665.1">
        <property type="nucleotide sequence ID" value="XM_028743832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J503"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020529.1">
        <property type="protein sequence ID" value="ENSPMRP00000019336.1"/>
        <property type="gene ID" value="ENSPMRG00000012611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604071"/>
    <dbReference type="KEGG" id="pmua:114604071"/>
    <dbReference type="CTD" id="6189"/>
    <dbReference type="GeneTree" id="ENSGT00390000018433"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="264" mass="29852" checksum="D85B30D13A57B7FB" modified="2020-06-17" version="1">MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRTNQIRKTSYAQHQQVRQIRKKMVEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVYVRKVKMLKKPKFELGKLMELHGEGGGAGKPSGDETGAKVERADGYEPPVQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J737</accession>
    <name>A0A670J737_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J737"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021253.1">
        <property type="protein sequence ID" value="ENSPMRP00000020015.1"/>
        <property type="gene ID" value="ENSPMRG00000013037.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182788"/>
    <dbReference type="OMA" id="KRIHANH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="295" mass="32494" checksum="7947A8D5D78FB068" modified="2020-06-17" version="1">MFSDEKGLETCARCPVDQYPNEEQNECIPKKPNVLGFGETLAMVSTFSALLFSLITAMVLGLFIKHRDTAIVKANNRSLTYILLISLLLCFLCSLMFIGMPNKATCPLRQTAFGIVFSVALSSILAKTISVVLAFMATKPDSTIRKWVGKKLAYSIVLSCSVIQVGICAFWLATSAPFPDVDMHSSSEEIIFLCNEGSVLMFYGVLGYMGFLAIISFTVAFLARKLPDSFNEAKFITFSMLVFCSVWFSFIPTYLSTKGKYMVAVEIFSILASSAGLLGCIFSPKCYIIVVRPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J9N8</accession>
    <name>A0A670J9N8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J9N8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022309.1">
        <property type="protein sequence ID" value="ENSPMRP00000021011.1"/>
        <property type="gene ID" value="ENSPMRG00000013663.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157305"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="67" mass="7843" checksum="69A7B2EA5F095A47" modified="2020-06-17" version="1">GGERRGGGGEDPRREKELKRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGLSQNNLRVHYKGWETLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JA07</accession>
    <name>A0A670JA07_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114582690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028559745.1">
        <property type="nucleotide sequence ID" value="XM_028703912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JA07"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021276.1">
        <property type="protein sequence ID" value="ENSPMRP00000020036.1"/>
        <property type="gene ID" value="ENSPMRG00000013051.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000022408.1">
        <property type="protein sequence ID" value="ENSPMRP00000021105.1"/>
        <property type="gene ID" value="ENSPMRG00000013715.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000022414.1">
        <property type="protein sequence ID" value="ENSPMRP00000021111.1"/>
        <property type="gene ID" value="ENSPMRG00000013718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582690"/>
    <dbReference type="KEGG" id="pmua:114582690"/>
    <dbReference type="GeneTree" id="ENSGT01110000267181"/>
    <dbReference type="OMA" id="HAFSEGT"/>
    <dbReference type="OrthoDB" id="9041845at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000003">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="126" mass="13954" checksum="B64FAB09435B53C2" modified="2020-06-17" version="1">MPEPAKSAPAAKKGSKKAITKTQKKGDKKRKKSRKESYSIYVYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAL1</accession>
    <name>A0A670JAL1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ciliary neurotrophic factor receptor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CNTFR</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JAL1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021992.1">
        <property type="protein sequence ID" value="ENSPMRP00000020709.1"/>
        <property type="gene ID" value="ENSPMRG00000013451.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000021996.1">
        <property type="protein sequence ID" value="ENSPMRP00000020713.1"/>
        <property type="gene ID" value="ENSPMRG00000013451.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000022001.1">
        <property type="protein sequence ID" value="ENSPMRP00000020718.1"/>
        <property type="gene ID" value="ENSPMRG00000013451.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158864"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070110">
        <property type="term" value="C:ciliary neurotrophic factor receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097059">
        <property type="term" value="C:CNTFR-CLCF1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004897">
        <property type="term" value="F:ciliary neurotrophic factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019970">
        <property type="term" value="F:interleukin-11 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004921">
        <property type="term" value="F:interleukin-11 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000136">
        <property type="entry name" value="Ciliary neurotrophic factor receptor alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000564">
        <property type="entry name" value="Ciliary neurotrophic factor receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003530">
        <property type="entry name" value="Hematopoietin_rcpt_L_F3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050379">
        <property type="entry name" value="Type-I_Cytokine_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036:SF21">
        <property type="entry name" value="CILIARY NEUROTROPHIC FACTOR RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01354">
        <property type="entry name" value="HEMATOPO_REC_L_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="219"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="377" mass="42295" checksum="CBEEDC383E2B5473" modified="2020-06-17" version="1">MCSQESWLRECHFQPQNQECAELSWEEEFAPCSAPVQQFPDTESHIHYAQLGTDVTLQCGSVDRDAAVTWTANSTDLDASHLNGSRLVLRNVDLSHSGQYSCYEGSSWHLKYRVNLKVGTPPKEPALMCRSNNYPSGFYCSWHMPIPTYIPDTFNITVMHDSKEIVCDMDVSLKNRCYIRYLHLFSSKKYKVTLTVTNALGSSSTSISFDEFAIVKPDPPENVVAKPIPNNARRLLVTWQYPSSWPDPDSFPLKFFLRYRPLIIDQWQHVELSDGTTHIITDAYAGKEYIIQVAAKDNEIGTWSDWSVAVHATPWTEEPKHLTTEAQGAETTTASTSAFVVPTTTSIGNSEEQGSNGAIALSWVASLLLVAFSIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JB23</accession>
    <name>A0A670JB23_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PIM3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="RefSeq" id="XP_028602496.1">
        <property type="nucleotide sequence ID" value="XM_028746663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JB23"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021691.1">
        <property type="protein sequence ID" value="ENSPMRP00000020417.1"/>
        <property type="gene ID" value="ENSPMRG00000013298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605401"/>
    <dbReference type="KEGG" id="pmua:114605401"/>
    <dbReference type="CTD" id="415116"/>
    <dbReference type="GeneTree" id="ENSGT00940000153394"/>
    <dbReference type="OMA" id="WGTINGT"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061179">
        <property type="term" value="P:negative regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14102">
        <property type="entry name" value="STKc_PIM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000209">
        <property type="entry name" value="Serine/threonine-protein kinase pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017348">
        <property type="entry name" value="PIM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051138">
        <property type="entry name" value="PIM_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PIM-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037993">
        <property type="entry name" value="STPK_Pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="40"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="46"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="323" mass="36783" checksum="F24C535B907A36E7" modified="2020-06-17" version="1">MLLSKFGSLAHLCNPTSMDHLPVKILQPVKVEKEPFDKIYQVGSVLGSGGFGTVYAGNRISDGLPVAVKHVVRERVTEWGTIGGVMVPLEIVLLKKVGSGFRGVIKLLDWYERPDGYLIIMERPELVKDLFDFITEKGALDEETARGFFRQVLEAVRHCYSCGVVHRDIKDENLLVDLRTGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLYFRRRISPECQQLIKWCLSLRPSDRPTLEQIFDHPWMHKSDVAKSEDCDIRLRTIDTDVSSTSSSNESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JDN2</accession>
    <name>A0A670JDN2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A670JDN2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024053.1">
        <property type="protein sequence ID" value="ENSPMRP00000022633.1"/>
        <property type="gene ID" value="ENSPMRG00000014692.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161051"/>
    <dbReference type="OMA" id="SWIINAP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF899">
        <property type="entry name" value="ASTACIN-LIKE METALLOENDOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="51"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="259"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="373"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="495" mass="55717" checksum="E6AE5703FD38EE02" modified="2020-06-17" version="1">MLDTISLLYHMQRVAIVRWIIFEEGLHGRNPPLHTHSQFPRSPVLHEIFHNGIPRSAGNFPMLAKHILFEFHTHNMGTFNAFLSLPWIFLAVEERTVIAEAMQEFVTLTCIQFIRRSTEHDYINISLCWSYFGKIGGKQQLGLAKNGCIYKGLIQHEINHALGFIHEQARNDRDKYVKIHLEYVTAGEQGNFEKVDSNNLGLPYDYGSVMHYGPYDFSSAPGKATIVPIPNASVPIGQRIGLSDLDVKKINKLYRCNCCSTVLRNRRGNFSSTNYPYSYPKNVTCLWLIQIPEGKVFLKFHVLDLQRSPNCSSDYIRIYDGNNRNARLLVDKLCGEGQLPAVVSSGSMMLVEFVSDEAVASKGFTASYAHVICGGTFTSTHGVVTSPNFPRKYPPNKRCLWIISAPAGSRISLTMGFFDLEEAAGCNYDRLVFRDGSDISSPLLGTFCGKTEVPAFNSTGSFLRIEFYSDHVSQYSGFKQIKALFEPWRTGKSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JEA5</accession>
    <name>A0A670JEA5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein zwilch</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZWILCH</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RZZ complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Chromosome</location>
            <location evidence="1 9">Centromere</location>
            <location evidence="1 9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ZWILCH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028562826.1">
        <property type="nucleotide sequence ID" value="XM_028706993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JEA5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023889.1">
        <property type="protein sequence ID" value="ENSPMRP00000022485.1"/>
        <property type="gene ID" value="ENSPMRG00000014603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114584846"/>
    <dbReference type="KEGG" id="pmua:114584846"/>
    <dbReference type="CTD" id="55055"/>
    <dbReference type="GeneTree" id="ENSGT00390000013696"/>
    <dbReference type="OMA" id="PARTTWF"/>
    <dbReference type="OrthoDB" id="5556307at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018630">
        <property type="entry name" value="Zwilch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15995:SF1">
        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09817">
        <property type="entry name" value="Zwilch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="595" mass="68076" checksum="B9D2AADF88241A09" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JF06</accession>
    <name>A0A670JF06_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A670JF06"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023053.1">
        <property type="protein sequence ID" value="ENSPMRP00000021722.1"/>
        <property type="gene ID" value="ENSPMRG00000014095.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153394"/>
    <dbReference type="OMA" id="PITHKGG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14005">
        <property type="entry name" value="STKc_PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000708">
        <property type="entry name" value="serine/threonine-protein kinase par-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017348">
        <property type="entry name" value="PIM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051138">
        <property type="entry name" value="PIM_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PIM-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037993">
        <property type="entry name" value="STPK_Pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="40"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="306" mass="33902" checksum="ED3CAAFEEFBF5053" modified="2020-06-17" version="1">FDSGVGVWLAGRVPAQTRHADALLSFSPSPAGKATLETRYRLGALIGSGGFGTVYAGTRLSDSLPVAIKYVAKDRNGTLVPLEVVLLKKVSSSGCRGVIRLLDWFEQSDAYFIVMERPLVSQDLFDVITDRGPLPESLAAGYFRQVVEAVRHCHLCGVLHRDIKDENILVDLLQGDLKLIDFGSGALLRDAPYTDFDGTRVYSPPEWIKYHRYHGVSATVWSLGVLLYDMVCGDIPFERDEDILLGKLHYHCRVSSDCRHLIEWCLSLAPENRPSLEQILAHPWLLAFLEQAPGPSSSSSCCCFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JHL9</accession>
    <name>A0A670JHL9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mammalian ependymin-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EPDR1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binds anionic lipids and gangliosides at acidic pH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ependymin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028606776.1">
        <property type="nucleotide sequence ID" value="XM_028750943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JHL9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025408.1">
        <property type="protein sequence ID" value="ENSPMRP00000023946.1"/>
        <property type="gene ID" value="ENSPMRG00000015506.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607599"/>
    <dbReference type="KEGG" id="pmua:114607599"/>
    <dbReference type="CTD" id="54749"/>
    <dbReference type="GeneTree" id="ENSGT00940000161910"/>
    <dbReference type="OMA" id="TMKDCYP"/>
    <dbReference type="OrthoDB" id="6084362at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905573">
        <property type="term" value="F:ganglioside GM1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990764">
        <property type="term" value="P:myofibroblast contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00317">
        <property type="entry name" value="EPENDYMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00026">
        <property type="entry name" value="EPEND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025538391" description="Mammalian ependymin-related protein 1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="219" mass="24578" checksum="8024CF99F167CFFE" modified="2020-06-17" version="1">MAPGAFPGRRLLLALLLGGALSLAGGAPTATSTPPAVPCQAPLQWEGRTVVYDHSTGRSIRAAVSYDGQNQRLRVLEERKQLIPCKKFFEYIYLYKDTVMFQIEQVTKLCSKIALTEPWDPYDIPDNSTYEDQNYIGGPGDQIMVQEWSDRKPARKPETWVGVYTVKDCYPVQETYTRNYSVTTSTRFFDLKLGISDPSVFTPPSTCQTAQPNKMSDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJS3</accession>
    <name>A0A670JJS3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JJS3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026162.1">
        <property type="protein sequence ID" value="ENSPMRP00000024656.1"/>
        <property type="gene ID" value="ENSPMRG00000015931.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="135" mass="14886" checksum="2DE972194B905DD5" modified="2020-06-17" version="1">VSPSPGGSGDTHPQTPNFHIWGLVGIRQAHREIRLAKQLKKPKTLSSCEFFVLQGIRLARYHCTAVPWLSNLIRSGSPFDSRNCSKTKAWFPIGCRRFLHSIGSCGSCVRCSASQKHLQTGTLTSRFASFGSQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNQ7</accession>
    <name>A0A670JNQ7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JNQ7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027100.1">
        <property type="protein sequence ID" value="ENSPMRP00000025530.1"/>
        <property type="gene ID" value="ENSPMRG00000016540.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="FKGHMRI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="301" mass="34858" checksum="733133E6522484AE" modified="2020-06-17" version="1">MKETDPANLARMEGGRWTVDLVRLSPASLLSTSERSLPGTSERSDGDELEGKNKGEHNRIHIAEKSYKHSECGENIRQSSQDTCRQRKSFVQRDNLTAHKRGQSREKLYQCRECGKSFSNRRNLTFHQRIHTGEKPYQCLECGKTFRHSTTLTSHQRIHTGEKPYQCLQCGKSFREGTKLTSHQRTHTGEKPYQCFECGKSFSRRGNLTSHQRIHTGEKPYQCLECGKSFSLRQHLTSHQRTHTGEKPYQCLECGKSFSLRNNLTSHHRIHTGEKPYQCFECGKSFRMREELQNADQPYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JR15</accession>
    <name>A0A670JR15_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GJC2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 10">Cell membrane</location>
            <topology evidence="3 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the connexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JR15"/>
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        <property type="protein sequence ID" value="ENSPMRP00000026851.1"/>
        <property type="gene ID" value="ENSPMRG00000017345.1"/>
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    <dbReference type="GeneTree" id="ENSGT01150000286949"/>
    <dbReference type="OMA" id="ACTKGAG"/>
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        <property type="entry name" value="GAP JUNCTION GAMMA-2 PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0303">Gap junction</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="13">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="14">
        <location>
            <begin position="196"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="421" mass="47953" checksum="38712E18A58DEBC2" modified="2020-06-17" version="1">MTNMSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYSDEQSKFTCNTKQPGCDNVCYDAFAPLSHVRFWVFQIIMISTPSVIYLGYAIHRIARSSEEEKKRFRGFKKKKQFALNWQAVRNLEDPLGAEEEEPMIVDDVAESEEKVKTKEEKKKEQQQKKHDGRRHIQEEGLMKIYVFQLLTRASFEICFLIGQYMLYGFEVTPYYLCTRQPCPHDVDCFVSRPTEKTIFLLVMYVVSCLCLLLNVAEMCHLGIGTIRDAIHDRKVHSFRQPPYNYAAYPKNISCPPEYNLVVKSDKQAKVPNSLMAHEQNLANVAQEQQCTSPDENLPPDLSTLHKHLRVAQEQLDIAFQSYNHTQANGQPSRTSSSASGGMVAEQNRANTAQEKQGAKPKASSEKGSSNGKDGKNSVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JR50</accession>
    <name>A0A670JR50_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Membrane-associated phosphatidylinositol transfer protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphatidylinositol transfer protein, membrane-associated 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Pyk2 N-terminal domain-interacting receptor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PITPNM3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with PTK2B via its C-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JR50"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027975.1">
        <property type="protein sequence ID" value="ENSPMRP00000026370.1"/>
        <property type="gene ID" value="ENSPMRG00000017052.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153849"/>
    <dbReference type="OMA" id="PSIVWMR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Membrane-associated phosphatidylinositol transfer protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF27">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN BETA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24694">
        <property type="entry name" value="LNS2_PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24695">
        <property type="entry name" value="PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="14">
        <location>
            <begin position="417"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="317"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="952"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110625" checksum="66288AD25F5D88FD" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JRB8</accession>
    <name>A0A670JRB8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JRB8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027092.1">
        <property type="protein sequence ID" value="ENSPMRP00000025522.1"/>
        <property type="gene ID" value="ENSPMRG00000016536.1"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig/MHC_CS"/>
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        <property type="entry name" value="Ig_C1-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_V-set"/>
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        <property type="entry name" value="Immune_Resp_Modulators"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="V-set"/>
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    </dbReference>
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        <property type="entry name" value="IG"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
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        <location>
            <begin position="145"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="265"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="400" mass="41924" checksum="2255B73DB88F35E4" modified="2020-06-17" version="1">RRTVELGTPKVIHSNPLRCRLGGSGSGETRLVIPPRHWFTSPRFVPPADPSGALWGGQASATPPPWLSPDASEAESSCEINAYAPQESHFVPWAEGLAGGGGCPRALERGKWLIASIQAPDAEFGVSSVLHTEEAPPWKQQDGVSSVTTTAAVLSVFTRTPRLESRLGRPAVLHCGFSAPASAFSVEWRHQFRGAGKVVLAFDGASRGVSVAEEGAELLLDAEGGGASLRLRSVAVRHEGTYICTVYLPHLHAQQALEFKVVEPPQVTLRPTTLSVPPGARPQLACEVSGFFPLGASVSWKRRGSGAPQDAFLDIGDSGHRQAPDGTFSFTSFARLLPVPTEDHGVSYVCHVGHAGLGEAGVKKAVVLHVAGGGLHLGVCAGVPWGLGSKAQKTGCGCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTH9</accession>
    <name>A0A670JTH9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrin alpha-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">CD49 antigen-like family member B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Collagen receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Platelet membrane glycoprotein Ia</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">VLA-2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ITGA2</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="16">Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 23">Membrane</location>
            <topology evidence="1 23">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 23">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JTH9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027836.1">
        <property type="protein sequence ID" value="ENSPMRP00000026232.1"/>
        <property type="gene ID" value="ENSPMRG00000016975.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156303"/>
    <dbReference type="OMA" id="IQYASQW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045178">
        <property type="term" value="C:basal part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034666">
        <property type="term" value="C:integrin alpha2-beta1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098639">
        <property type="term" value="F:collagen binding involved in cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038064">
        <property type="term" value="F:collagen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048333">
        <property type="term" value="P:mesodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006929">
        <property type="term" value="P:substrate-dependent cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000008">
        <property type="entry name" value="Integrin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000012">
        <property type="entry name" value="Integrin, alpha 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF23">
        <property type="entry name" value="INTEGRIN ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 23" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 23" id="KW-0401">Integrin</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1055"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="24">
        <location>
            <begin position="98"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="22">
        <location>
            <begin position="399"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="22">
        <location>
            <begin position="463"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="22">
        <location>
            <begin position="525"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00080513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1107" mass="121987" checksum="5D13B3ADB0DA0570" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTL3</accession>
    <name>A0A670JTL3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cholecystokinin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CCK</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the gastrin/cholecystokinin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028607286.1">
        <property type="nucleotide sequence ID" value="XM_028751453.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028607287.1">
        <property type="nucleotide sequence ID" value="XM_028751454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JTL3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027866.1">
        <property type="protein sequence ID" value="ENSPMRP00000026262.1"/>
        <property type="gene ID" value="ENSPMRG00000016992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607862"/>
    <dbReference type="KEGG" id="pmua:114607862"/>
    <dbReference type="CTD" id="885"/>
    <dbReference type="GeneTree" id="ENSGT00390000003571"/>
    <dbReference type="OMA" id="YSGLCIC"/>
    <dbReference type="OrthoDB" id="9862982at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051428">
        <property type="term" value="F:peptide hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038188">
        <property type="term" value="P:cholecystokinin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042755">
        <property type="term" value="P:eating behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015499">
        <property type="entry name" value="CCK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001651">
        <property type="entry name" value="Gastrin/CCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013152">
        <property type="entry name" value="Gastrin/cholecystokinin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10786">
        <property type="entry name" value="CHOLECYSTOKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10786:SF0">
        <property type="entry name" value="CHOLECYSTOKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00918">
        <property type="entry name" value="Gastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00029">
        <property type="entry name" value="GASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00259">
        <property type="entry name" value="GASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0027">Amidation</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0765">Sulfation</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025541292" evidence="8">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Gastrin/cholecystokinin peptide hormone" evidence="9">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="125" mass="13700" checksum="C4E7F8863B367666" modified="2020-06-17" version="1">MYSGVCICLLLAALSTSSLGQQTSGSHNANPVATDLEKSLLETYRHVRTPGSGKSIQQLDGNVDPKANLGALLAKYLQQARRGASGKVSVMGLQSFDPTHRIRDRDYMGWMDFGRRSAEEYEYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTR4</accession>
    <name>A0A670JTR4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF384</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JTR4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030266.1">
        <property type="protein sequence ID" value="ENSPMRP00000028533.1"/>
        <property type="gene ID" value="ENSPMRG00000018429.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156904"/>
    <dbReference type="OMA" id="SICSHAY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000233">
        <property type="entry name" value="Putative zinc finger protein 362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000158">
        <property type="entry name" value="Zinc finger protein 362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000377">
        <property type="entry name" value="zinc finger protein 362 isoform X4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000433">
        <property type="entry name" value="zinc finger protein 384 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000216">
        <property type="entry name" value="Zinc finger protein 384 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Marsik P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the TFIIB family.</text>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
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        <lineage>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JUN8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030655.1">
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        <property type="gene ID" value="ENSPMRG00000018685.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025479169" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="211" mass="23522" checksum="5C0089FB92BB80FD" modified="2020-06-17" version="1">MFFLVFLLEGVTSQSAWTQPASESPASESVSPGQTIKLSCTTSDTGSGVRWYQQRSGQVPRFVQYEGGSRGEGIPDRFTASRSGNIGYLTITNLQAEDEAVYYCARGYKNLFHSDTNQWGSGTKTFPLPPNSMRCSTLQKAVFPGPFLKDFLIDVPSWLSHHILAELRANPAALKNLLYANLPFDSLIECPIMFYRISKSQERQSMITEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JV19</accession>
    <name>A0A670JV19_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Piwi-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PIWIL2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028564523.1">
        <property type="nucleotide sequence ID" value="XM_028708690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JV19"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028911.1">
        <property type="protein sequence ID" value="ENSPMRP00000027254.1"/>
        <property type="gene ID" value="ENSPMRG00000017581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585806"/>
    <dbReference type="CTD" id="55124"/>
    <dbReference type="GeneTree" id="ENSGT00950000183200"/>
    <dbReference type="OMA" id="CILNTAN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033391">
        <property type="term" value="C:chromatoid body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:dense body"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010370">
        <property type="term" value="C:perinucleolar chromocenter"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071546">
        <property type="term" value="C:pi-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:piRNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030718">
        <property type="term" value="P:germ-line stem cell population maintenance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042754">
        <property type="term" value="P:negative regulation of circadian rhythm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140991">
        <property type="term" value="P:piRNA-mediated gene silencing by mRNA destabilization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000767">
        <property type="term" value="P:positive regulation of cytoplasmic translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060903">
        <property type="term" value="P:positive regulation of meiosis I"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140965">
        <property type="term" value="P:secondary piRNA processing"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141008">
        <property type="term" value="P:transposable element silencing by mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141196">
        <property type="term" value="P:transposable element silencing by piRNA-mediated DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141006">
        <property type="term" value="P:transposable element silencing by piRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000141">
        <property type="entry name" value="piwi-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000014">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="14">
        <location>
            <begin position="374"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="15">
        <location>
            <begin position="653"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="959" mass="108499" checksum="F87F573CF7B696F2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWB5</accession>
    <name>A0A670JWB5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Serine/threonine-protein kinase 36</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Fused homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">STK36</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028597784.1">
        <property type="nucleotide sequence ID" value="XM_028741951.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000031349.1">
        <property type="protein sequence ID" value="ENSPMRP00000029558.1"/>
        <property type="gene ID" value="ENSPMRG00000019111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603156"/>
    <dbReference type="KEGG" id="pmua:114603156"/>
    <dbReference type="CTD" id="27148"/>
    <dbReference type="GeneTree" id="ENSGT00940000158375"/>
    <dbReference type="OMA" id="LCPSFLH"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14002">
        <property type="entry name" value="STKc_STK36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000292">
        <property type="entry name" value="Serine/threonine-protein kinase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000325">
        <property type="entry name" value="Serine/threonine-protein kinase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983">
        <property type="entry name" value="PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="308"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00053117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00072550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00075375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1324" mass="146433" checksum="8FC7486AC6485774" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWC1</accession>
    <name>A0A670JWC1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JWC1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031354.1">
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        <property type="gene ID" value="ENSPMRG00000019117.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="NEMELEC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        <location>
            <begin position="95"/>
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        </location>
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        <location>
            <begin position="34"/>
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        </location>
    </feature>
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        <location>
            <begin position="102"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13521" checksum="1657A7C0A2BFB716" modified="2020-06-17" version="1">PSFKPLCPAKPSPSFLELPSTQWRPSPGLPYTQTPTSACSLPSSSLSPAPEHQPQECFGLLECMHNNIQTQTQIAQAQLSLLEDMRESMNILLARQEKQNQERLGQSDQRTTKSSASSPNPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Keratin"/>
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    </dbReference>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10566" checksum="1A0FC836E6E0D71E" modified="2020-06-17" version="1">MINTTKNGIIQKKGLCMRKGRTQIYNRINILHFFDVGCITQTPPSQVCIQPAPCCVVLPGPMLCASGEPVRVGGQTACLGTSSFGAGLGYGYSGRYSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0G3</accession>
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        <name evidence="6" type="primary">CAPS2</name>
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    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
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        <lineage>
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            <taxon>Squamata</taxon>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028745703.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028745704.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028745705.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028745706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K0G3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030209.1">
        <property type="protein sequence ID" value="ENSPMRP00000028477.1"/>
        <property type="gene ID" value="ENSPMRG00000018391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604993"/>
    <dbReference type="KEGG" id="pmua:114604993"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="479"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="613" mass="70787" checksum="FEFCD88F66BC2C84" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0K1</accession>
    <name>A0A670K0K1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dual specificity phosphatase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DUSP14</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028563476.1">
        <property type="nucleotide sequence ID" value="XM_028707643.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028707644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K0K1"/>
    <dbReference type="SMR" id="A0A670K0K1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030888.1">
        <property type="protein sequence ID" value="ENSPMRP00000029119.1"/>
        <property type="gene ID" value="ENSPMRG00000018824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585216"/>
    <dbReference type="KEGG" id="pmua:114585216"/>
    <dbReference type="CTD" id="11072"/>
    <dbReference type="GeneTree" id="ENSGT00940000160675"/>
    <dbReference type="OMA" id="TENMVWL"/>
    <dbReference type="OrthoDB" id="285418at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14572">
        <property type="entry name" value="DUSP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000049">
        <property type="entry name" value="Dual specificity protein phosphatase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
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        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 14"/>
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        <property type="entry name" value="IP21249P"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
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        <property type="entry name" value="ADSPHPHTASEB"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="167"/>
        </location>
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        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="198" mass="22641" checksum="F9CCDCD283920396" modified="2020-06-17" version="1">MTSRRHYTLPRTLMTPRLYSEGALGGIAQITPFLYISKGSVASNRQLLLARGITCIVNATIELPNFNFPEFEYVKVPVADMPNAPISLYFDSVADKIQSVARKHGVTLVHCAAGVSRSATLCIAYLMKYQNVTLLEAYNWVKSRRPVIHPNVGFWRQLIDYERELYGRNTVKMVQTPYGIMPDVYMRERRTFVPYWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K1Y1</accession>
    <name>A0A670K1Y1_PODMU</name>
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        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K1Y1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030715.1">
        <property type="protein sequence ID" value="ENSPMRP00000028952.1"/>
        <property type="gene ID" value="ENSPMRG00000018722.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154869"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
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        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
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        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="126"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18252" checksum="4010E4415B51ECA9" modified="2020-06-17" version="1">MQETGAENDLCTPASLQASPGDRVTIQCKAASSVGRYMALYQFKSGQNPKLLIYGGSTRFEGTPDRFSGSYSGNDFSFTINGVHAEDEGVYCCGQHNTTPLHSDTLQYKNQLSGLRQQEGMAVGVLQQHRPCSLLNERGLEWSMTKGVRTNGSADQPIGRQPGPDCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K288</accession>
    <name>A0A670K288_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K288"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030830.1">
        <property type="protein sequence ID" value="ENSPMRP00000029062.1"/>
        <property type="gene ID" value="ENSPMRG00000018788.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154179"/>
    <dbReference type="OMA" id="ADYYCHT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="104" mass="11198" checksum="78A4F31D8DA1A51C" modified="2020-06-17" version="1">AKDNIPTMTQPASVSAPPRQTTKLSCTASGSVSYIVWIQQKPGQAPRFVHCDTCSSKGQGIPDRFTASRSGTTGYLTITGTESEDEAAYYCAAWFSSMWHSAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3L4</accession>
    <name>A0A670K3L4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C-X-C chemokine receptor type 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CXCR5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K3L4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033262.1">
        <property type="protein sequence ID" value="ENSPMRP00000031361.1"/>
        <property type="gene ID" value="ENSPMRG00000020326.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244848"/>
    <dbReference type="OMA" id="FTKNCLL"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
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        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016494">
        <property type="term" value="F:C-X-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042113">
        <property type="term" value="P:B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030595">
        <property type="term" value="P:leukocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="C-X-C chemokine receptor type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001053">
        <property type="entry name" value="Chemokine_CXCR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF618">
        <property type="entry name" value="C-X-C CHEMOKINE RECEPTOR TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00564">
        <property type="entry name" value="CXCCHMKINER5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0075">B-cell activation</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="50"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="346" mass="38891" checksum="DA4B19D60998BCE5" modified="2020-06-17" version="1">PGPALYGLGGHSQSPVLSGFNLNLLSTTRQLRAFLVPFVYMLIFLLGGVGNLMVIVILWCYRRSRSSTELFLFHLALANLLLVFTFPFGVVQNIAGWIFGPFLCKVLSATNRINFYSSSLLLGCISVERYLAVVHALWAFQKQRAISVHLTCLGVWVVSLLLTLPDLLFTEVWPSRDNQPSICHFREYGKHGINAWLATRFLYHIVGFFLPSLVMCFCYIAIVRVLCRSQRLKRQKVVRVAILVTSVFLFCWTPYHVVIFLDTLNKLATANNGCAVELNTAIILSEMVAFSHCCLNPILYAFVGIRFRHDACRLLNSLGCLSQSTLQDILGTCRMDSSTTFLKSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K482</accession>
    <name>A0A670K482_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cartilage associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CRTAP</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leprecan family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028606756.1">
        <property type="nucleotide sequence ID" value="XM_028750923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K482"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031540.1">
        <property type="protein sequence ID" value="ENSPMRP00000029737.1"/>
        <property type="gene ID" value="ENSPMRG00000019235.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607593"/>
    <dbReference type="KEGG" id="pmua:114607593"/>
    <dbReference type="CTD" id="10491"/>
    <dbReference type="GeneTree" id="ENSGT00940000153814"/>
    <dbReference type="OMA" id="WPETVEY"/>
    <dbReference type="OrthoDB" id="8610171at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901874">
        <property type="term" value="P:negative regulation of post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001015">
        <property type="entry name" value="Cartilage associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001533">
        <property type="entry name" value="Cartilage associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052284">
        <property type="entry name" value="Collagen_mod_leprecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056585">
        <property type="entry name" value="Leprecan_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986:SF3">
        <property type="entry name" value="CARTILAGE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986">
        <property type="entry name" value="PROTEIN LYSINE HYDROXYLATION COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23557">
        <property type="entry name" value="TPR_leprecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025676434" evidence="4">
        <location>
            <begin position="36"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Leprecan-like alpha-helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="420" mass="48954" checksum="1D13F0099205FB2D" modified="2020-06-17" version="1">MWRLVCARRPPLLLLAAPALLLLLLLCLRAPGCRAQFERYSFRSFPRDELMPLESAYRYGLDQYGAEKWPESVSYLEVSLRLHRLLRDSEAFCHVNCSSARARDYEAAGGGGGEPGRFEGFAELRFFGDLLRRAQCLKRCKQGLPAFRQSQPSREVLAEFQQLEPYKFLQFAYFKANNFPKAIAAAHTFLLKHPEDEMMKRNMAYYKSMPDAEDHIKDLEMKSYENLFIRAVKAYNGENWRTSITDMELAIPDFYKAYDDCIAACEGSREITDFKEFYLSIADHYIEVLECKLKCEIDLTPVIGGYVVEKFVATMYHYLQFAYYKLNDLRNAASCVVSYLLFDQTDGVMKQNLVYYQYHKDKWGLTDEDFQPRPEAVRYYNITTLQREMYEFAKEHVMDDDEGEVVEYLDELLEVDGGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4G9</accession>
    <name>A0A670K4G9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein jagunal homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">JAGN1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the jagunal family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028575537.1">
        <property type="nucleotide sequence ID" value="XM_028719704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K4G9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032401.1">
        <property type="protein sequence ID" value="ENSPMRP00000030549.1"/>
        <property type="gene ID" value="ENSPMRG00000019778.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591937"/>
    <dbReference type="KEGG" id="pmua:114591937"/>
    <dbReference type="CTD" id="84522"/>
    <dbReference type="GeneTree" id="ENSGT00390000005596"/>
    <dbReference type="OMA" id="PYGVLWY"/>
    <dbReference type="OrthoDB" id="8914197at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038158">
        <property type="term" value="P:granulocyte colony-stimulating factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901142">
        <property type="term" value="P:insulin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030223">
        <property type="term" value="P:neutrophil differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002446">
        <property type="term" value="P:neutrophil mediated immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990266">
        <property type="term" value="P:neutrophil migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009787">
        <property type="entry name" value="Jagunal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955:SF1">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07086">
        <property type="entry name" value="Jagunal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="183" mass="21078" checksum="4052C623C409813C" modified="2020-06-17" version="1">MASRAGPRAAGTDGSDFQHRERVAKHYQMSVSLKSEIKKLIYMQIALWLLVAAQMCIAHFKLLPHDQVAMPYQWEYPYLLSIIPSLFGLFSFPRNNISYLVISMISTGLFSVAPLIYGSMEMFPMAQQLYRHGKAYRFIFGFSAVSVMYLLVVVAVQVHGWQLYYSKKLLDSWFTSTQEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9K7</accession>
    <name>A0A670K9K7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Endothelin receptor type B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114589115</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028571032.1">
        <property type="nucleotide sequence ID" value="XM_028715199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K9K7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033397.1">
        <property type="protein sequence ID" value="ENSPMRP00000031482.1"/>
        <property type="gene ID" value="ENSPMRG00000020402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114589115"/>
    <dbReference type="KEGG" id="pmua:114589115"/>
    <dbReference type="GeneTree" id="ENSGT01150000286932"/>
    <dbReference type="OMA" id="TIFMVGI"/>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004962">
        <property type="term" value="F:endothelin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048484">
        <property type="term" value="P:enteric nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042310">
        <property type="term" value="P:vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15977">
        <property type="entry name" value="7tmA_ET-CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000076">
        <property type="entry name" value="Endothelin receptor type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000499">
        <property type="entry name" value="Endthln_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001112">
        <property type="entry name" value="ETB_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051193">
        <property type="entry name" value="GPCR_endothelin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46099:SF4">
        <property type="entry name" value="ENDOTHELIN RECEPTOR TYPE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46099">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00571">
        <property type="entry name" value="ENDOTHELINBR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00366">
        <property type="entry name" value="ENDOTHELINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025399299" evidence="14">
        <location>
            <begin position="24"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="109"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="436" mass="48881" checksum="2F339D259D09E52A" modified="2020-06-17" version="1">MGKFSALPVLAYCLACLILRVSSQTAVSFRNTPIPFEVLDQDKAYSLIQPGIFTNSRATANHSGNLIGDAITEGPQLSVMCAKPTEIRQAFKYINTFVSCTIFIVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIALPINVYKLLAEDWPFGVQVCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIQGIGIPMWKAVEVTLIWAVAIILAVPEAIAFDLVELNYREQTHWVCMLAAEQKSSFMTFYKDVKDWWLFGFYFCLPLACTGVFYSLMSCEMLSKRNGMRIALNDHMKRRREVAKTVFCLVVIFALCWLPLHLSRILKKTIYSQQDADRCELLSFLLVMDYFGINMASLNSCINPVALYFVSRKFKNCFQSCLCCWCQRPALGIAPTDDKGSVGKWKANGQELGLDRSSSHLKYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9M4</accession>
    <name>A0A670K9M4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K9M4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035067.1">
        <property type="protein sequence ID" value="ENSPMRP00000033050.1"/>
        <property type="gene ID" value="ENSPMRG00000021418.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166058"/>
    <dbReference type="OMA" id="GNWNYTA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000001">
        <property type="entry name" value="Cryptochrome 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="248"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="288"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="384"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="574" mass="65422" checksum="6546136F32C8EF3B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K9U9</accession>
    <name>A0A670K9U9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K9U9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034315.1">
        <property type="protein sequence ID" value="ENSPMRP00000032359.1"/>
        <property type="gene ID" value="ENSPMRG00000020972.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155611"/>
    <dbReference type="OMA" id="RNIMYFX"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000276">
        <property type="entry name" value="zinc finger protein 385A isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000121">
        <property type="entry name" value="zinc finger protein 385B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000293">
        <property type="entry name" value="zinc finger protein 385B isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051845">
        <property type="entry name" value="Znf385"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23067">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23067:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 385D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="542" mass="58802" checksum="ADA9E1BF422B78B6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAU9</accession>
    <name>A0A670KAU9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KAU9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035531.1">
        <property type="protein sequence ID" value="ENSPMRP00000033490.1"/>
        <property type="gene ID" value="ENSPMRG00000021715.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164016"/>
    <dbReference type="OMA" id="PPWSTNT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF77">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="190" mass="21096" checksum="22D4C9C34CF430D8" modified="2020-06-17" version="1">MDQYLSGHLPATPWTSGRSTAGKAPPWSTNTSPQRSHLLPTFARASTGPPSPSPPSPGSNRNPAPSWPGQAQPGHGRPSPTLATLAVPIPKYSQRNNPELEKRRVHHCDYSGCTKVYTKSSHLKAHQRTHTGEKPYRCAWDGCEWCFARSDELTRHYRKHTGAKPFGCLACGRCFSRSDHLALHMKRHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDV6</accession>
    <name>A0A670KDV6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CAAX prenyl protease 2</fullName>
            <ecNumber evidence="11">3.4.26.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Farnesylated proteins-converting enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RCE1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028565176.1">
        <property type="nucleotide sequence ID" value="XM_028709343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KDV6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035856.1">
        <property type="protein sequence ID" value="ENSPMRP00000033804.1"/>
        <property type="gene ID" value="ENSPMRG00000021918.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114586218"/>
    <dbReference type="KEGG" id="pmua:114586218"/>
    <dbReference type="CTD" id="9986"/>
    <dbReference type="GeneTree" id="ENSGT00390000004124"/>
    <dbReference type="OMA" id="HSFCNWC"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008238">
        <property type="term" value="F:exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="14">
        <location>
            <begin position="148"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="317" mass="34836" checksum="68DE48DF8F77CEC2" modified="2020-06-17" version="1">MSEETAAGAGPGGSGSGLCWASLFSCLSLACCYVGSLYVWKSHLPRDHPAVIKRRFTSVLIVSILSPIFIWAWKEVTGIKPDASLLALMGFRLEGIIPATVLPLLLTMVLFLGPLIQLSMDCPWDLVEGLKVAFDPSFWVLCLTDMRWLRNQVIAPFTEELVFRACMLPMLVPCTGLGPAVFTCPLFFGVAHFHHVIEQLRFRQGSTASIFLSAVFQFSYTAVFGTYTAFIFIRTGHLIGPVLCHSFCNYVGFPAVGAALDHPQRCLVVFFYLLGVILFLLLLHPMTDPAFFGHLPICSLSRLTSHTSSLGSFSLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KE21</accession>
    <name>A0A670KE21_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670KE21"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035084.1">
        <property type="protein sequence ID" value="ENSPMRP00000033067.1"/>
        <property type="gene ID" value="ENSPMRG00000021427.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163111"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14209">
        <property type="entry name" value="STKc_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044109">
        <property type="entry name" value="STKc_PKA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF82">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0114">cAMP</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0519">Myristate</keyword>
    <keyword evidence="12 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="44"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="408" mass="47147" checksum="25A28F2B12EC0148" modified="2020-06-17" version="1">MGNAATAKKGGEIESVKEFLAKAKEEFLKKWENPLQNTSSLDHFDRLKTLGTGSFGRVMLVKHKETGNYFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIEVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVRRSRKVQSEEGGGLWQQPTALFTKQRFPLPHCQRSNANSLWVCSAGTQSHPNTHITFWKRIAHKQESPPPTKLISVLRKPACEAALTLQWNLQAQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEK4</accession>
    <name>A0A670KEK4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formin like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FMNL3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KEK4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036104.1">
        <property type="protein sequence ID" value="ENSPMRP00000034039.1"/>
        <property type="gene ID" value="ENSPMRG00000021374.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159962"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000001">
        <property type="entry name" value="Formin-like 1, isoform CRA_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000036">
        <property type="entry name" value="Formin-like protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000045">
        <property type="entry name" value="Formin-like protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF3">
        <property type="entry name" value="FORMIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="534"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="945"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="992" mass="113689" checksum="0CCB4F762E0F83E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFH0</accession>
    <name>A0A670KFH0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KFH0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037801.1">
        <property type="protein sequence ID" value="ENSPMRP00000035661.1"/>
        <property type="gene ID" value="ENSPMRG00000023048.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234712"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="268"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="722" mass="83581" checksum="44271CC3801B7201" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KFT6</accession>
    <name>A0A670KFT6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="32">NAD-dependent protein deacylase sirtuin-6</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="34">NAD-dependent protein deacetylase sirtuin-6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="33">Protein mono-ADP-ribosyltransferase sirtuin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="38" type="primary">SIRT6</name>
    </gene>
    <organism evidence="38 39">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="38 39" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="38" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="38" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19149"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:15087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142554"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:19150"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-lysyl-[protein] + NAD(+) = N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142515"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:58221"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:43637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="31">Homodimer; binds to nucleosomes and DNA ends as a homodimer. Interacts with RELA; interferes with RELA binding to target DNA. Interacts with SMARCA5; promoting recruitment of SMARCA5/SNF2H to double-strand breaks (DSBs) sites. Interacts with the mTORC2 complex; preventing the ability of SIRT6 to deacetylate FOXO1. Interacts with the CLOCK-BMAL1 complex; recruited by the CLOCK-BMAL1 complex to regulate expression of clock-controlled genes. Interacts with CSNK2A2; preventing CSNK2A2 localization to the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028569603.1">
        <property type="nucleotide sequence ID" value="XM_028713770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KFT6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038447.1">
        <property type="protein sequence ID" value="ENSPMRP00000036283.1"/>
        <property type="gene ID" value="ENSPMRG00000023429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588457"/>
    <dbReference type="KEGG" id="pmua:114588457"/>
    <dbReference type="CTD" id="51548"/>
    <dbReference type="GeneTree" id="ENSGT00940000160088"/>
    <dbReference type="OMA" id="EQCKKCR"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140612">
        <property type="term" value="F:DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035033">
        <property type="term" value="F:histone deacetylase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097372">
        <property type="term" value="F:histone H3K18 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140765">
        <property type="term" value="F:histone H3K56 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106222">
        <property type="term" value="F:lncRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140773">
        <property type="term" value="F:NAD-dependent protein demyristoylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140774">
        <property type="term" value="F:NAD-dependent protein depalmitoylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000773">
        <property type="term" value="P:negative regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120186">
        <property type="term" value="P:negative regulation of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905555">
        <property type="term" value="P:positive regulation of blood vessel branching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000774">
        <property type="term" value="P:positive regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902732">
        <property type="term" value="P:positive regulation of chondrocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000738">
        <property type="term" value="P:positive regulation of stem cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902459">
        <property type="term" value="P:positive regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032206">
        <property type="term" value="P:positive regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905564">
        <property type="term" value="P:positive regulation of vascular endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160239">
        <property type="term" value="P:transcription pausing by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01410">
        <property type="entry name" value="SIRT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.200:FF:000001">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000029">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0007">Acetylation</keyword>
    <keyword evidence="24" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 35" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="39" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="19" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="15 35" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="37">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="305"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="36">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="35">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="35">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="35">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="35">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="35">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00050163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00050216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00051286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00066285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00071352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00076455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00083163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="344" mass="37723" checksum="FA61E071CAB95663" modified="2020-06-17" version="1">MSANYAAGLSPYSDKGKCGLPEFFDPPDELDKKVAQLALLIRDASNVVFHTGAGISTSSGIPDFRGPNGVWTMEERGLSPKFDTTFENARPSTTHMALLELQRAGVLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECMKCGKQYVRDAVVGTMGLKPTGRLCDVSKRRGLRSCRGKLMDTILDWEDSLPDRDLHLASEACRSADLSITLGTSLQIKPSGDLPLLTKKKGGKLVIVNLQPTKHDKHADLRIHGYVDDVMAKLMKHLGLEIPEWTRPLVVEKAELAESKAFAKPSIDFKFLTKAEPLGGNPEDGASPKQEPCATPDSDRVVAKRLKLEPLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KJ00</accession>
    <name>A0A670KJ00_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Centromere/kinetochore protein zw10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">ZW10</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="21">Interacts with NBAS and KNTC1/ROD; the interactions are mutually exclusive and indicative for its association in two different vesicle tethering complexes. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH. Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex). Interacts directly with RINT1/TIP20L bound to BNIP1/SEC20L. Interacts with C19orf25 and ZWINT. Interacts with ZFYVE1. Interacts with RAB18 and this interaction is enhanced in the presence of ZFYVE1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZW10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028563710.1">
        <property type="nucleotide sequence ID" value="XM_028707877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KJ00"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038444.1">
        <property type="protein sequence ID" value="ENSPMRP00000036280.1"/>
        <property type="gene ID" value="ENSPMRG00000023428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585332"/>
    <dbReference type="KEGG" id="pmua:114585332"/>
    <dbReference type="CTD" id="9183"/>
    <dbReference type="GeneTree" id="ENSGT00390000016427"/>
    <dbReference type="OMA" id="HHLLTMG"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.150:FF:000001">
        <property type="entry name" value="centromere/kinetochore protein zw10 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009361">
        <property type="entry name" value="Zw10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06248">
        <property type="entry name" value="Zw10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="20" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="16 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 N-terminal" evidence="24">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="25">
        <location>
            <begin position="187"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="26">
        <location>
            <begin position="481"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="27">
        <location>
            <begin position="629"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00065852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF06248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="784" mass="88635" checksum="B665852BAFEE4498" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KK73</accession>
    <name>A0A670KK73_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ethanolamine kinase</fullName>
            <ecNumber evidence="12">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ETNK1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="12"/>
    <dbReference type="RefSeq" id="XP_028603019.1">
        <property type="nucleotide sequence ID" value="XM_028747186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KK73"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038915.1">
        <property type="protein sequence ID" value="ENSPMRP00000036745.1"/>
        <property type="gene ID" value="ENSPMRG00000023668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114605685"/>
    <dbReference type="KEGG" id="pmua:114605685"/>
    <dbReference type="CTD" id="55500"/>
    <dbReference type="GeneTree" id="ENSGT00950000182939"/>
    <dbReference type="OMA" id="FALIPKY"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000002">
        <property type="entry name" value="Ethanolamine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF91">
        <property type="entry name" value="ETHANOLAMINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="381" mass="43349" checksum="7FF4938346863744" modified="2020-06-17" version="1">MANYIHVPPGSPEVPKLDVVVSERDPASGAGGGGGGDGEGGGGGPGYRRGALRLLSQLRPAWKPEEVTLKVFTDGITNKLIGCYVGEEMDDVVLVRIYGNKTELLVDREEEVKSFRVLQAHGCAPQLYCTFRNGLCYEFMEGEALDPEHVCNPEIFRLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTEFADEELHKRFIADVPSPQILQEEMAWMKERLSNLGSPVVLCHNDLLCKNIIYNGKQGDVKFIDYEYCGYNYLAYDIGNHFNEFAGVSEVDYSLYPSRKLQEQWLRSYLEAYKEYKGFGTDVTEKEVEVLYVQVNQFALASHFFWGLWALIQAKYSTIDFDFLGYAIVRFNQYFKMKNEVMTLKLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KL56</accession>
    <name>A0A670KL56_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Persephin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PSPN</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TGF-beta family. GDNF subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KL56"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039275.1">
        <property type="protein sequence ID" value="ENSPMRP00000037090.1"/>
        <property type="gene ID" value="ENSPMRG00000023874.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182993"/>
    <dbReference type="OMA" id="SECSCIG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030116">
        <property type="term" value="F:glial cell-derived neurotrophic factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035860">
        <property type="term" value="P:glial cell-derived neurotrophic factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19382">
        <property type="entry name" value="TGF_beta_Persephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043401">
        <property type="entry name" value="GDNF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173">
        <property type="entry name" value="GDNF SUBFAMILY OF TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173:SF8">
        <property type="entry name" value="PERSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="149" mass="16498" checksum="1C1ABF6888841D4F" modified="2020-06-17" version="1">PHLPSPILPFLLISETQTSQGASLDTAGHQNSLLKSLPGPARSRPKRRAWERPEDRECRLRSLQVRVKNLGLGYSSEETILFKYCSGSCPKARSNHDLTLSALLQRSEIPALGDPCCRPTHYEDVAFLDDSHQWQEVEQLSAAACSCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KL82</accession>
    <name>A0A670KL82_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L antigen family member 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KL82"/>
    <dbReference type="Ensembl" id="ENSPMRT00000039310.1">
        <property type="protein sequence ID" value="ENSPMRP00000037125.1"/>
        <property type="gene ID" value="ENSPMRG00000023892.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00980000202880"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000037125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="150" mass="17165" checksum="FD6F7D4C8964EE87" modified="2020-06-17" version="1">MLRKILPEPLQVRDTQASEELSTQIFRRARIAFCNVFHIILRKFLSSSGRYGAEGNGTPSPAHTHRRQHTHTHTQREGERERERESIALGSLAPDPEPRKEGISKELDVTEDIFRWRADEARILRVSISSFLEHLSLVVETMDLFGPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HLD9</accession>
    <name>A0A670HLD9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HLD9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000318.1">
        <property type="protein sequence ID" value="ENSPMRP00000000301.1"/>
        <property type="gene ID" value="ENSPMRG00000000224.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282534"/>
    <dbReference type="OMA" id="YKLAIHQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="13"/>
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        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 510 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="21"/>
    </dbReference>
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        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
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        <location>
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        <location>
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        <location>
            <begin position="252"/>
            <end position="279"/>
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    <feature type="domain" description="C2H2-type" evidence="12">
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        <location>
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            <end position="391"/>
        </location>
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            <end position="419"/>
        </location>
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        <location>
            <begin position="420"/>
            <end position="447"/>
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            <end position="475"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="637" mass="72747" checksum="BAF49C108C2B06E2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HLP4</accession>
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        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 7B, mitochondrial</fullName>
        </recommendedName>
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        </alternativeName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase VIIb family.</text>
    </comment>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_c_oxidase_suVIIB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16716">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16716:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL"/>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="63" mass="7157" checksum="44EC688FF9B45F09" modified="2020-06-17" version="1">MRPAARQVRSKHGPDFHDKYGSLILLGGALFCASIWSYVVTQTGIEWNLSPVGRITPKEWREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMG7</accession>
    <name>A0A670HMG7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC73</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670HMG7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000884.1">
        <property type="protein sequence ID" value="ENSPMRP00000000833.1"/>
        <property type="gene ID" value="ENSPMRG00000000605.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013482"/>
    <dbReference type="OMA" id="CNTISKM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031650">
        <property type="entry name" value="CCDC73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28660">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28660:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15818">
        <property type="entry name" value="CCDC73"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="854" mass="96587" checksum="AA0C8619C7E7925D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HNE0</accession>
    <name>A0A670HNE0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HNE0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000001466.1">
        <property type="protein sequence ID" value="ENSPMRP00000001379.1"/>
        <property type="gene ID" value="ENSPMRG00000001035.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156207"/>
    <dbReference type="OMA" id="ECDICAT"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000806">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF96">
        <property type="entry name" value="GENE, 32687-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="402" mass="45182" checksum="9402F406AD3CE70E" modified="2020-06-17" version="1">MPNMAASVVPRGGAGGDVEGILVEGEHSEVSSKGSKEEGEQRKLRVQDGGSRREGRRKQKPEGDSCMSQGGENQIPREDKKHECSVCGKRLGSRSTLTLHQRSHTGEKPYTCSECGKSFSNSSYRKSHQRTHTGEKPYKCLECGKSFSETSSLTLHLRTHTGEKPYTCSECGKSFNHTGTLTLHKRSHTGEKPYTCSECGRSFSQSSTLKSHQRSHTGEKPYTCSECGRSFSQSSTLKSHQRTHTGEKQHTCLECGMSFAYRNALTRHQQIHRGNKPYKCWECGKSFSRNDSLSLHERVHTGEKQYTCLECGKSFRHSASLTLHQRLHTGEKPYKCLECGKSFCHGRQLTSHQRTHTGEQPYTCLECGRNFSHLSAFKVHQRTHTGEKPYTCSGVWKKLQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HP39</accession>
    <name>A0A670HP39_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670HP39"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000845.1">
        <property type="protein sequence ID" value="ENSPMRP00000000797.1"/>
        <property type="gene ID" value="ENSPMRG00000000586.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000248530"/>
    <dbReference type="OMA" id="WAPIMAS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF30">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="368"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="956" mass="108978" checksum="8103719473841B0C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPH1</accession>
    <name>A0A670HPH1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCAN box domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    </organism>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSPMRT00000001838.1">
        <property type="protein sequence ID" value="ENSPMRP00000001729.1"/>
        <property type="gene ID" value="ENSPMRG00000001275.1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028724459.1"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="997" mass="109459" checksum="E2617ECAA6CB1A85" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTG0</accession>
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        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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                <person name="Marsik P."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Peripla_BP_I"/>
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        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_3"/>
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    </dbReference>
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        <property type="entry name" value="ANF_receptor"/>
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    </dbReference>
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        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VOMERONASL2R"/>
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    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
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        <location>
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            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="798" mass="90075" checksum="8609BB53DE80EAC5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUW7</accession>
    <name>A0A670HUW7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Potassium two pore domain channel subfamily K member 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">KCNK10</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Cs(+)(in) = Cs(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78555"/>
            <dbReference type="ChEBI" id="CHEBI:49547"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Rb(+)(in) = Rb(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78547"/>
            <dbReference type="ChEBI" id="CHEBI:49847"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028718089.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028573931.1">
        <property type="nucleotide sequence ID" value="XM_028718098.1"/>
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    <dbReference type="Ensembl" id="ENSPMRT00000003258.1">
        <property type="protein sequence ID" value="ENSPMRP00000003040.1"/>
        <property type="gene ID" value="ENSPMRG00000002170.1"/>
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    <dbReference type="KEGG" id="pmua:114591286"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098782">
        <property type="term" value="F:mechanosensitive potassium channel activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904551">
        <property type="term" value="P:cellular response to arachidonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000043">
        <property type="entry name" value="Potassium channel subfamily K member 10 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
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        <property type="entry name" value="2pore_dom_K_chnl_TREK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF32">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01499">
        <property type="entry name" value="TREKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="150"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="245"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="539" mass="60375" checksum="3E906044BD9BBF9F" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HVX8</accession>
    <name>A0A670HVX8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">WARS1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670HVX8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003638.1">
        <property type="protein sequence ID" value="ENSPMRP00000003395.1"/>
        <property type="gene ID" value="ENSPMRG00000002392.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153724"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="term" value="C:protein-containing complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein domain specific binding"/>
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        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:regulation of angiogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd00936">
        <property type="entry name" value="WEPRS_RNA"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.287.10:FF:000004">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
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        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
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    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
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        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WHEP_TRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="13">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023146"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000003395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="473" mass="53571" checksum="C9DCA71945A0B361" modified="2020-06-17" version="1">MADLQNCDFCSLNPLELFEQVTAQGEKVRSLKAEKAPKDDIDTAVQLLLSLKLSYKTATGEEYKAGSPPTDFTPVSNGPGDTEDNDFVDPWTVQTSNAKGVDYDKLIVRFGSSKIDKDLINRIERVTGHKPHHFLRRGIFFSHRDMNQILDAYENKKPFYLYTGRGPSAEAMHVGHLIPFTFTKWLQEVFNVPLVIQITDDEKYLWKDMTLEKAYQCAIENIKDIIACGFDINKTFIFSDLEYLGMSPGFYRNIVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSSSFPQIFNNKSNIPCLIPCAIDQDPYFRMTRDVAPRIGFSKPALLHSVFFPALQGAQTKMSSSDPNSSIFLTDTPKQIKTKINKHAFSGGKDTVEEHRKYGGNCDVDVSYMYLTFFLEDDDKLEQIKQAYTSGALLTGELKKALIETLQPLIAAHQQRRKQITDEIVKEFMTPRKLAFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HWU1</accession>
    <name>A0A670HWU1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Phospholipase A2</fullName>
            <ecNumber evidence="4 13">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PLA2G4F</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The N-terminal C2 domain associates with lipid membranes upon calcium binding.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="4 13"/>
    <dbReference type="AlphaFoldDB" id="A0A670HWU1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004297.1">
        <property type="protein sequence ID" value="ENSPMRP00000004026.1"/>
        <property type="gene ID" value="ENSPMRG00000002757.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234606"/>
    <dbReference type="OMA" id="PMRLKTR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071236">
        <property type="term" value="P:cellular response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04036">
        <property type="entry name" value="C2_cPLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000030">
        <property type="entry name" value="Phospholipase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000002">
        <property type="entry name" value="Phospholipase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041847">
        <property type="entry name" value="C2_cPLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040723">
        <property type="entry name" value="cPLA2_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF22">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2 ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18695">
        <property type="entry name" value="cPLA2_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12 13" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10 12 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="15">
        <location>
            <begin position="305"/>
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        <scope>IDENTIFICATION</scope>
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    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:57722"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A670HYY6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004645.1">
        <property type="protein sequence ID" value="ENSPMRP00000004352.1"/>
        <property type="gene ID" value="ENSPMRG00000002964.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074800"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="177"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="516" mass="55644" checksum="85D7B944F0A7FE0C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HZA9</accession>
    <name>A0A670HZA9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HZA9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000004774.1">
        <property type="protein sequence ID" value="ENSPMRP00000004477.1"/>
        <property type="gene ID" value="ENSPMRG00000003062.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155748"/>
    <dbReference type="OMA" id="HLIVCQF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="38"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="138" mass="15497" checksum="28AF01A7E2F2677C" modified="2020-06-17" version="1">MQLFSHSELESLKTQIRGLETELEGLKSAITKTQKGDYDAARETCLRMGGALASPRNAAENSALQKIVTWYNRRAVLGINDMATEGRFEYLNGDVIGYSNWAPGEPNNLGNEDCVEMHQDGKWHDRGCTLEWLVICEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I025</accession>
    <name>A0A670I025_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:64324"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:75121"/>
            <dbReference type="ChEBI" id="CHEBI:88768"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:64325"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:64328"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:152049"/>
            <dbReference type="ChEBI" id="CHEBI:152050"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:64329"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:64320"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:84323"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:64321"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:42796"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:41509"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42797"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:42792"/>
            <dbReference type="ChEBI" id="CHEBI:3663"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42793"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + cholesterol = cholesteryl octadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:42812"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:82750"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:42813"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Endoplasmic reticulum membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I025"/>
    <dbReference type="Ensembl" id="ENSPMRT00000005139.1">
        <property type="protein sequence ID" value="ENSPMRP00000004820.1"/>
        <property type="gene ID" value="ENSPMRG00000003285.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183081"/>
    <dbReference type="OMA" id="SCMIEDV"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034736">
        <property type="term" value="F:cholesterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF6">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000004820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="495" mass="58194" checksum="37053AD13D00F968" modified="2020-06-17" version="1">MVMADDSQLNASLPTCQNGPWGLGEPKHSACWFETILESLCPMQRHFFPRLTPPQKKMVMVLCMLTDGFCRKYSENNLFEVEHIRTIYHMFIALLILFILSTLIVDFIDEGRLVLEFDLLVYAFGKSSVVFSTWLYMFLSTLTVPYGLFLLWAQGYHSSSHKTIHSAFFGGLFTIFQIFGLGMGPAYIAVAYNLPPASAFIVILEQVRLLMKGYSFIRENAPRILSFTPQKTNTVQVPKVSQYLYFLFAPTLIYRDAYPRNPTIRWSYVATKFAQVLGSLFYTYYIFVRLCIPTFRNYKENLNVRGLVLCIFNSILPGVLMLFLVFFAYLHCWLNAFAEMLRFADRMFYKDWWNSTSYAKYYRTWNVVVHDWLYYYAYKDFLWLFGKKFKAVAMLSVFTLSAIVHEYVLAVCFGYFYPVLFCLFMCFGMVFNFILNDRRKGPIWNVFMWSTLFLGQGVILTLYSLEWYAYKHCPLKNPTFLDYVKPRSWTCHLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I1W0</accession>
    <name>A0A670I1W0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FKBP3 basic tilted helix bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670I1W0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000006215.1">
        <property type="protein sequence ID" value="ENSPMRP00000005841.1"/>
        <property type="gene ID" value="ENSPMRG00000003967.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000185109"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041200">
        <property type="entry name" value="FKBP3_BTHB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18410">
        <property type="entry name" value="BTHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FKBP3 basic tilted helix bundle" evidence="2">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000005841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="78" mass="9044" checksum="AA61F37D875F5D04" modified="2020-06-17" version="1">CPHGRPQRTSLDLRELFPHRLTKEIVCFLQEQVAHKFLSEHKLLGQIKNVAKTASKEQLIITSSLKPRDLRVLRVQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I3X5</accession>
    <name>A0A670I3X5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 162 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CEP162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP162 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028722891.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028722892.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028722893.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028722894.1"/>
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        <property type="nucleotide sequence ID" value="XM_028722895.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000006564.1"/>
        <property type="gene ID" value="ENSPMRG00000004434.1"/>
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    <dbReference type="KEGG" id="pmua:114593918"/>
    <dbReference type="CTD" id="22832"/>
    <dbReference type="GeneTree" id="ENSGT00390000009631"/>
    <dbReference type="OMA" id="PDMTDNE"/>
    <dbReference type="OrthoDB" id="2157184at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038774">
        <property type="entry name" value="CEP162-like"/>
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        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="258"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="525"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="928"/>
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    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="737"/>
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    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="825"/>
            <end position="866"/>
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    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1003"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1082"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1218"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1302"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="95"/>
            <end position="111"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="133"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="217"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="241"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="360"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1458" mass="165774" checksum="109A5D6D33F41D00" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I448</accession>
    <name>A0A670I448_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">[histone H3]-lysine(9) N-methyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">EHMT2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.367"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60284"/>
            <dbReference type="Rhea" id="RHEA-COMP:15541"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.367" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A670I448"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007078.1">
        <property type="protein sequence ID" value="ENSPMRP00000006644.1"/>
        <property type="gene ID" value="ENSPMRG00000003611.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159459"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070742">
        <property type="term" value="F:C2H2 zinc finger domain binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0140759">
        <property type="term" value="F:histone H3K56 methyltransferase activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0140948">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:promoter-specific chromatin binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0048148">
        <property type="term" value="P:behavioral response to cocaine"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071314">
        <property type="term" value="P:cellular response to cocaine"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:1902902">
        <property type="term" value="P:negative regulation of autophagosome assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048599">
        <property type="term" value="P:oocyte development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035265">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of DNA replication"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20905">
        <property type="entry name" value="EHMT_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10533">
        <property type="entry name" value="SET_EHMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000005">
        <property type="entry name" value="Euchromatic histone-lysine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000029">
        <property type="entry name" value="histone-lysine N-methyltransferase EHMT1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043550">
        <property type="entry name" value="EHMT1/EHMT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047762">
        <property type="entry name" value="EHMT_CRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038034">
        <property type="entry name" value="SET_EHMT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21533">
        <property type="entry name" value="EHMT1-2_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
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    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 19" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="644"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="677"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="744"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="19">
        <location>
            <begin position="810"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="22">
        <location>
            <begin position="932"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="21">
        <location>
            <begin position="998"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="240"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="522"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051161"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00066816"/>
        </source>
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    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000006644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1170" mass="128834" checksum="4E01CD0B877474E9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6F9</accession>
    <name>A0A670I6F9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MAK</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028593571.1">
        <property type="nucleotide sequence ID" value="XM_028737738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I6F9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000007827.1">
        <property type="protein sequence ID" value="ENSPMRP00000007312.1"/>
        <property type="gene ID" value="ENSPMRG00000004953.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600908"/>
    <dbReference type="KEGG" id="pmua:114600908"/>
    <dbReference type="CTD" id="4117"/>
    <dbReference type="GeneTree" id="ENSGT00940000156581"/>
    <dbReference type="OMA" id="MASEYTW"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902856">
        <property type="term" value="P:negative regulation of non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000104">
        <property type="entry name" value="serine/threonine-protein kinase MAK isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000071">
        <property type="entry name" value="serine/threonine-protein kinase MAK isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
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    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="4"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
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            <dbReference type="Ensembl" id="ENSPMRP00000007312.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="657" mass="73753" checksum="C61D034DCB1D96A6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I7U3</accession>
    <name>A0A670I7U3_PODMU</name>
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        <submittedName>
            <fullName evidence="3">Lymphocyte antigen 86</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LY86</name>
    </gene>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="155" mass="17587" checksum="7F6574259D7C0AD5" modified="2020-06-17" version="1">MFKVVSFVFLLVYTTPSIEWPTHLLCKTDRLEVNYRSCDPLQDLAFSIDTCSSVVPETINIRIATILRYSIRKLSVEVTLGMNGASVPFYSKELCEEDHPEFLYCGKKKGELIYYEGPVSLGFHELPLGDLGVKVELLNQDHHTIICANFTVKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IAL6</accession>
    <name>A0A670IAL6_PODMU</name>
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        <recommendedName>
            <fullName evidence="11">Protocadherin-15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PCDH15</name>
    </gene>
    <organism evidence="17 18">
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        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000009287.1">
        <property type="protein sequence ID" value="ENSPMRP00000008692.1"/>
        <property type="gene ID" value="ENSPMRG00000005842.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050953">
        <property type="term" value="P:sensory perception of light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000047">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000048">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000049">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000056">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000057">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000063">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041149">
        <property type="entry name" value="EC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030718">
        <property type="entry name" value="EC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056989">
        <property type="entry name" value="PCDH15_12th_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18432">
        <property type="entry name" value="ECD"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IAT9</accession>
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        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="11">Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.</text>
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        <text evidence="11">Homodimer. Heterodimer; with a rar molecule.</text>
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        <subcellularLocation>
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        <text evidence="11">Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.</text>
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        <text evidence="1">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
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        </source>
    </evidence>
    <sequence length="481" mass="52780" checksum="EC3673CF6D71151E" modified="2020-06-17" version="1">MWGAVITSKVICIYLFVTRLHGVSLFISDSPVHSNSAPANLGSGLPTGNSLDGTSNYLESPLSASRTLSSPMSSAASVNTMSSPYRVLTSSMGSHSVPLSSPAGVNFAAHTSPQLNVMNSVSSSEDIKPLPGLQGMGAMNYASTSPGSLTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRSRERSENEAESTSSCGSSNEDMPVERILEAEMAVEPKTESYSDVSADNSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVQRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSSPAEVESLREKVYAALEAYTKQKYPDQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ID76</accession>
    <name>A0A670ID76_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A670ID76"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010496.1">
        <property type="protein sequence ID" value="ENSPMRP00000009850.1"/>
        <property type="gene ID" value="ENSPMRG00000006588.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001447"/>
    <dbReference type="OMA" id="CHLMIED"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000191">
        <property type="entry name" value="ribulose-phosphate 3-epimerase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="330" mass="35513" checksum="776B37201E5973AA" modified="2020-06-17" version="1">MSGGKNSRGVASGEVSEAGQARATLTEKPRRGSRTTFPIRRALPPGAFVSGQARRAGGSLATKLSRPFAMASGCRVGPSILNSDLAALGAECGRMVDCGADYLHLDVMDGHFVPNITFGHPVVESLRKQLGQQPFFDMHMMVAKPEQWVKPMAVAGANQYTFHIEATNNPGALIKDIRENGMKVGLAIKPGTTVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKVHWLRTQFPSLDIEVDGGVGPDTIHKCAEAGANMIVSGSAIMKSDDPRAVINLLRNASQRLEVNSSPAVDEKDSSMHNSSLSHCEKSFCIVNTTSTLIQQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IDG6</accession>
    <name>A0A670IDG6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IDG6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010361.1">
        <property type="protein sequence ID" value="ENSPMRP00000009718.1"/>
        <property type="gene ID" value="ENSPMRG00000006510.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="RHTCESQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000116">
        <property type="entry name" value="Zinc finger protein 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000030">
        <property type="entry name" value="Zinc finger protein 628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="501" mass="56779" checksum="1A3CE273BA1E37E1" modified="2020-06-17" version="1">WALLDPDQRALHKDIMEENSGINGLSCFLNSKLHMSRTSYILTDLNSALLTVNFQELLGKVEVASVQVFRFCFSSRQSLVVQREEMSVDPLNKYLECGKSSFSTSHQRNPIGKKPYQCMECGKRFTQKVNLTSHQRIHTGEKPYQCVECGKSFRNSSKLTSHQRIHTGEKPYQCGECGKSFTHSHNLTSHHRIHTGEKPYQCVECGKSFTESSSLTSHQRIHTGEKPYQCVECGKSFSTSSSLSSHQRIHTGEKPYQCVECGKSFRNSSKLTSHHRIHTGEKPYQCVECGKSFTDISTLTSHQKIHTGEKPYPCVECGKSFTQSHNLTSHQIIHTGEKPYQCVDCGKSFSHSSSLTRHQRIHTGEKPYQCVECEKTFSQSASLTFHQRIHTGEKPYQCVECGKSFSFNHHLTSHQRIHTGEKPYQCVECEKTFSQSTSLTSHQRIHTGEKPYQCVECGKSFSQSSSLTSHHRIHTGEKPYHDKRGAAGFCPGPVVVQRLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IE34</accession>
    <name>A0A670IE34_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IE34"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010598.1">
        <property type="protein sequence ID" value="ENSPMRP00000009948.1"/>
        <property type="gene ID" value="ENSPMRG00000006659.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286962"/>
    <dbReference type="OMA" id="QSWMASS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="367" mass="40844" checksum="75B381BB3530ED10" modified="2020-06-17" version="1">MVDHELLDHRLADVGIQGTVLQWLRSFLSGRGQRVALGGELSSRHSLVCGVPQGAILSPMLFNIFMRPLAQLVRSFGLGCHQYADDTQLYLLMDGHPDSAPDTLTRCLEAVAGWLRGSRLKLNPAKTEVLWLGRDDMGSGGQLPSLAGVQLVPAPSVKSLGVIFDTSLSMEAQITAITKAAFFHLRQAKQLAPYLSRPDLATVIHATVTSRLDYCNSLYVGLPLRLTQKLQRVQNAAARLLTGSSLRDHIHPVLYHLHWLPVEYRIKFKVLVLTFKALYGLGPPYLRDRLSWYAPQRNLRSVNKNILKVPGLREVRLALTRARAFSAAAPIWWNALSQETRALRDLTSFRRACKTELFHQAFGQGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEF1</accession>
    <name>A0A670IEF1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Transient receptor potential cation channel subfamily A member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Ankyrin-like with transmembrane domains protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Wasabi receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">TRPA1</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="26">Homotetramer. Interacts with TMEM100. Interacts with EGLN1. Interacts with the scorpion wasabi receptor toxin at the same site that electrophiles but in a non-covalent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the transient receptor (TC 1.A.4) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000010518.1">
        <property type="protein sequence ID" value="ENSPMRP00000009872.1"/>
        <property type="gene ID" value="ENSPMRG00000006600.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156118"/>
    <dbReference type="OMA" id="HWATEKN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032421">
        <property type="term" value="C:stereocilium bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015278">
        <property type="term" value="F:intracellularly gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097604">
        <property type="term" value="F:temperature-gated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071240">
        <property type="term" value="P:cellular response to food"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050968">
        <property type="term" value="P:detection of chemical stimulus involved in sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050966">
        <property type="term" value="P:detection of mechanical stimulus involved in sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048265">
        <property type="term" value="P:response to pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050955">
        <property type="term" value="P:thermoception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000272">
        <property type="entry name" value="Transient receptor potential cation channel subfamily A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
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        <location>
            <begin position="1061"/>
            <end position="1083"/>
        </location>
    </feature>
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            <begin position="1126"/>
            <end position="1152"/>
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        <location>
            <begin position="962"/>
            <end position="1160"/>
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    </feature>
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            <begin position="50"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00061660"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00063125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00074970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00079767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00079849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1307" mass="146467" checksum="8AEFA74B388CA2EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEM6</accession>
    <name>A0A670IEM6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CA2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="RefSeq" id="XP_028592423.1">
        <property type="nucleotide sequence ID" value="XM_028736590.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000011054.1">
        <property type="protein sequence ID" value="ENSPMRP00000010380.1"/>
        <property type="gene ID" value="ENSPMRG00000006899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600457"/>
    <dbReference type="KEGG" id="pmua:114600457"/>
    <dbReference type="CTD" id="760"/>
    <dbReference type="GeneTree" id="ENSGT00940000160385"/>
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    <dbReference type="OrthoDB" id="429145at2759"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038166">
        <property type="term" value="P:angiotensin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:carbon dioxide transport"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:morphogenesis of an epithelium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:neuron cellular homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032849">
        <property type="term" value="P:positive regulation of cellular pH reduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001150">
        <property type="term" value="P:positive regulation of dipeptide transmembrane transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001225">
        <property type="term" value="P:regulation of chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046903">
        <property type="term" value="P:secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Carbonic anhydrase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF120">
        <property type="entry name" value="CARBONIC ANHYDRASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="258" mass="28432" checksum="E3ADEB30607514FE" modified="2020-06-17" version="1">MSWGYGKDNGPAHWHENFPIANGERQSPINIQPKSAKYDASLKSLNISYDPSAAKNIVNNGHSFNVEFDDSGDKCVLKGGPVEGTYKLLQFHIHWGSCEGQGSEHTVDGVKYDAELHLVHWNTKYGSSGEAVKHPDGLAVVGVFLKVGSACPGIQKVVDALDTIKHKGKQAAFTNFDPTGLLPASRDFWTYPGSLTTPPLLECVTWIVLKEPVTVSKEQMDKLRCLCFSCEGESHCAMVDNWRPCQPLKTREVRASFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IG45</accession>
    <name>A0A670IG45_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="31">Solute carrier family 17 member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="31" type="primary">SLC17A6</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:71255"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>K(+)(in) + H(+)(out) = K(+)(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29467"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>phosphate(in) = phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:32823"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Synapse</location>
            <location evidence="23">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028585007.1">
        <property type="nucleotide sequence ID" value="XM_028729174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IG45"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011462.1">
        <property type="protein sequence ID" value="ENSPMRP00000010748.1"/>
        <property type="gene ID" value="ENSPMRG00000007139.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597072"/>
    <dbReference type="KEGG" id="pmua:114597072"/>
    <dbReference type="CTD" id="57084"/>
    <dbReference type="GeneTree" id="ENSGT00940000155891"/>
    <dbReference type="OMA" id="YNEQSQM"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140788">
        <property type="term" value="F:L-glutamate uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098700">
        <property type="term" value="P:neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055062">
        <property type="term" value="P:phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050803">
        <property type="term" value="P:regulation of synapse structure or activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17382">
        <property type="entry name" value="MFS_SLC17A6_7_8_VGluT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000004">
        <property type="entry name" value="vesicular glutamate transporter 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000005">
        <property type="entry name" value="vesicular glutamate transporter 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF201">
        <property type="entry name" value="VESICULAR GLUTAMATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0868">Chloride</keyword>
    <keyword evidence="16" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="7" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="8 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="30">
        <location>
            <begin position="70"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00035839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00036616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00038044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="585" mass="64830" checksum="A6DED2930A3891EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670II13</accession>
    <name>A0A670II13_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neuralized E3 ubiquitin protein ligase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NEURL2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028591531.1">
        <property type="nucleotide sequence ID" value="XM_028735698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670II13"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012013.1">
        <property type="protein sequence ID" value="ENSPMRP00000011244.1"/>
        <property type="gene ID" value="ENSPMRG00000007519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599889"/>
    <dbReference type="KEGG" id="pmua:114599889"/>
    <dbReference type="CTD" id="140825"/>
    <dbReference type="GeneTree" id="ENSGT00940000159689"/>
    <dbReference type="OMA" id="RIGIIYV"/>
    <dbReference type="OrthoDB" id="10059069at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF8">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="3">
        <location>
            <begin position="8"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="2">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="267" mass="29580" checksum="5B9586366371779C" modified="2020-06-17" version="1">MSAAGHPPTRFHRIHGANVCVDPSGTQATRVESFANGVCFSRQPLAPGQIFLVEIEEKELGWCGHLRVGLTAHDPRSLETVPEYSLPDLVNLGDTWVFAITRNHNRVAQDAAGEEASARVRGFLSDPYLLIEKVRIPRDKLVGRSRPGRYSHLLDDLYRTNMLPATARRSRIGVLFAPQPDGTADMHIVINGEDMGPSARGLPGSRPLYAVVDIFASTKSVRLIQVEYGFPSLQTLCRLAIQKHIAHRLDIDGLDLPPLLKNFCKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ILF8</accession>
    <name>A0A670ILF8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ILF8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013750.1">
        <property type="protein sequence ID" value="ENSPMRP00000012878.1"/>
        <property type="gene ID" value="ENSPMRG00000008613.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="QHYCKES"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003000">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001024">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 20"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002134">
        <property type="entry name" value="Zinc finger protein 616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000990">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001700">
        <property type="entry name" value="Zinc finger protein 677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000862">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF73">
        <property type="entry name" value="ZINC FINGER PROTEIN 572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="469" mass="53274" checksum="19D06CD6CF6790E6" modified="2020-06-17" version="1">KYVGDHDKIPREEKPLYQCIECGKRFTRSSSLSSHHRIHTGEKPYQCVECGKSFRQSANLTSHQRIHTGEKPYQCVECGKSFSTNSNLTSHHRIHTGEKPYQCVECGKSFRQSANLTFHQKIHTGQKPYQCVECGKSFRQSANLTFHQKIHTGEKLYQCVECGKSFSQSSALTSHQRIHTGEKPYQCVECGKSFSQSSSLTSHHRIHTGEKPYQCVECGKSFSKSSHLTSHQRIHTGEKPYQCVECGKSFSTSSDLTFHQKIHTGEKPYQCVECGKSFRQSTDLTSHQRIHTGEKPYQCVECGKSFRKSSNLTSHQRIHTGEKPYQCVECGKSFTHSSSLTYHRIIHTGQKPYQCVECGKSFRQSTDLTSHQRIHTGEKPYQCVECGKSFSKSSHLTSHQRIHTGEKPYQCMECGKSFSQSSNLTSHQKIHTGEKPYQCAECGKSFTVTSKLTSHQRIHTKIGKTIIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IN26</accession>
    <name>A0A670IN26_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IN26"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014235.1">
        <property type="protein sequence ID" value="ENSPMRP00000013335.1"/>
        <property type="gene ID" value="ENSPMRG00000008920.1"/>
    </dbReference>
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    <dbReference type="OMA" id="WHERNLI"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
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        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF14">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="149" mass="18014" checksum="C0498FFB1A00707D" modified="2020-06-17" version="1">MLRHGWRTGAIVPELETEIRIINTEQYMHSLTWQQALTGLLERMQMYQDAESRQVLLEWMKERQEIRIFLTPNFGSIFRTFHNPTYFSRRLIRFSDIYMASISCLLNYDVNFTFYPRRTPLQHEAPLWMDQLCTGCMKTPFLEEMVHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IP94</accession>
    <name>A0A670IP94_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cholinergic receptor nicotinic alpha 9 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CHRNA9</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IP94"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014403.1">
        <property type="protein sequence ID" value="ENSPMRP00000013486.1"/>
        <property type="gene ID" value="ENSPMRG00000009026.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156077"/>
    <dbReference type="OMA" id="CVYDVGE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098878">
        <property type="term" value="C:neurotransmitter receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0095500">
        <property type="term" value="P:acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050910">
        <property type="term" value="P:detection of mechanical stimulus involved in sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990806">
        <property type="term" value="P:ligand-gated ion channel signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051899">
        <property type="term" value="P:membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010996">
        <property type="term" value="P:response to auditory stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19022">
        <property type="entry name" value="LGIC_ECD_nAChR_A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000009">
        <property type="entry name" value="Cholinergic receptor nicotinic alpha 9 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000053">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000010">
        <property type="entry name" value="neuronal acetylcholine receptor subunit alpha-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="33"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="244"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="489" mass="55530" checksum="0B87002FE0741285" modified="2020-06-17" version="1">TIPNNQPCLLKCIILYTTANIIIGSSQGKYAQMLFNELFEDYSNALRPVEDTDSVLNVTLQITLSQIKDMDERNQILTAYLWIRQTWYDAYLKWDKDEYDGLDSIRIPSNLVWRPDIVLYNKADDDFSEPVNTNIVLRHDGKITWDSPAITKSSCVVDVSYFPFDSQECNLTFGSWTYNGNQVDIFNSLDSGDLSDFIEDVEWEIHGMPAVRNVITYGCCSEPYPDVTFTLILKRKSSFYIFNLLLPCLLISFLAPLGFYLPADSGEKVSLGVTVLLALTVFQLMVAESMPPSENVPLIGKYYIATMTMITASTALTIIIMNIHYCGSGAKPVPQWARVVILDYMSKIFFVYDVGENCTSLQRVKERDPKAEKTNSACRKDQDRYEGTRRPLAKIQHGGCDLKKKPPDDVCDGSGVPGENARDIVSCCSCYRILIKNIEYIASCVRRHKANHAKGVEWKKVAKVMDRFFMWIFFIMVFFMSVLVMGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISF2</accession>
    <name>A0A670ISF2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670ISF2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015083.1">
        <property type="protein sequence ID" value="ENSPMRP00000014117.1"/>
        <property type="gene ID" value="ENSPMRG00000009432.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000170288"/>
    <dbReference type="OMA" id="MISQDSQ"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="124" mass="14170" checksum="10CC7BE83D60F84E" modified="2020-06-17" version="1">MTINSRLQLVKKSGKYVLGYKLTLKMISQDSQLCPAVQAHGNTVYLPRPCGKYYRVYTLTIIDPGDSDFLRSMQEQTSEKQTSLNFKFWVIILATNKNKSNKQTKNQQPAHLAVPKHVKVQVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISI3</accession>
    <name>A0A670ISI3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho guanine nucleotide exchange factor 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARHGEF26</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028587173.1">
        <property type="nucleotide sequence ID" value="XM_028731340.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028587174.1">
        <property type="nucleotide sequence ID" value="XM_028731341.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028587175.1">
        <property type="nucleotide sequence ID" value="XM_028731342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670ISI3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015715.1">
        <property type="protein sequence ID" value="ENSPMRP00000014711.1"/>
        <property type="gene ID" value="ENSPMRG00000009827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597901"/>
    <dbReference type="KEGG" id="pmua:114597901"/>
    <dbReference type="CTD" id="26084"/>
    <dbReference type="GeneTree" id="ENSGT01030000234571"/>
    <dbReference type="OMA" id="SPKYEAC"/>
    <dbReference type="OrthoDB" id="27593at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001886">
        <property type="term" value="P:endothelial cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097178">
        <property type="term" value="P:ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01221">
        <property type="entry name" value="PH_ephexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11938">
        <property type="entry name" value="SH3_ARHGEF16_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000127">
        <property type="entry name" value="Neuronal guanine nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000007">
        <property type="entry name" value="rho guanine nucleotide exchange factor 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000153">
        <property type="entry name" value="rho guanine nucleotide exchange factor 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035797">
        <property type="entry name" value="ARHGEF16/ARHGEF26_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047270">
        <property type="entry name" value="PH_ephexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845:SF4">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="8">
        <location>
            <begin position="433"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="649"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="783"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="865" mass="97463" checksum="22F268ACCD43B9C5" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ISW2</accession>
    <name>A0A670ISW2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">E3 ubiquitin-protein ligase SHPRH</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">RING-type E3 ubiquitin transferase SHPRH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">SNF2, histone-linker, PHD and RING finger domain-containing helicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">SHPRH</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016281.1">
        <property type="protein sequence ID" value="ENSPMRP00000015238.1"/>
        <property type="gene ID" value="ENSPMRG00000010158.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111123"/>
    <dbReference type="OMA" id="FIIPEIM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="Histone_H1/H5_H15"/>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="zf-RING_UBOX"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0347">Helicase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="H15" evidence="26">
        <location>
            <begin position="285"/>
            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="1286"/>
            <end position="1333"/>
        </location>
    </feature>
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        <location>
            <begin position="1368"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="422"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="456"/>
            <end position="467"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00064042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00080750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082267"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1537" mass="177066" checksum="8789E8F46EB190B3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IT06</accession>
    <name>A0A670IT06_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 9A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TTC9B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TTC9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IT06"/>
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        <property type="protein sequence ID" value="ENSPMRP00000014594.1"/>
        <property type="gene ID" value="ENSPMRG00000009737.1"/>
    </dbReference>
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    <dbReference type="OMA" id="RVREYCF"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000264">
        <property type="entry name" value="Tetratricopeptide repeat protein 9A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
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</entry>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cell junction</location>
            <location evidence="12">Tight junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 15">Belongs to the ELL/occludin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028748441.1"/>
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    <dbReference type="RefSeq" id="XP_028604275.1">
        <property type="nucleotide sequence ID" value="XM_028748442.1"/>
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        <property type="nucleotide sequence ID" value="XM_028748443.1"/>
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        <property type="protein sequence ID" value="ENSPMRP00000016723.1"/>
        <property type="gene ID" value="ENSPMRG00000011125.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Marvel"/>
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        <property type="entry name" value="Occludin"/>
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        <property type="entry name" value="Occludin_ELL"/>
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        <property type="entry name" value="OCCLUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
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    </dbReference>
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        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Occludin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OCCLUDIN"/>
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        <property type="entry name" value="occludin/ELL-like"/>
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    </dbReference>
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        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0796">Tight junction</keyword>
    <keyword evidence="6 12 14" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="148"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="180"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="252"/>
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        <location>
            <begin position="60"/>
            <end position="277"/>
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    </feature>
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        <location>
            <begin position="412"/>
            <end position="520"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
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        </location>
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        <location>
            <begin position="427"/>
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        </location>
    </feature>
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        <location>
            <begin position="393"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016772"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR005993"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="520" mass="58254" checksum="C6914DE9441D8F55" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="9">Forkhead box C2</fullName>
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        <name evidence="9" type="primary">FOXC2</name>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF68">
        <property type="entry name" value="FORKHEAD BOX PROTEIN C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
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        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="72"/>
            <end position="166"/>
        </location>
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        <location>
            <begin position="72"/>
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        </location>
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        <location>
            <begin position="168"/>
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            <begin position="489"/>
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        </location>
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            <begin position="171"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="533" mass="57788" checksum="7170F0BA03E4608D" modified="2020-06-17" version="1"> </sequence>
</entry>
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        <recommendedName>
            <fullName evidence="3">Vitelline membrane outer layer 1 homolog</fullName>
        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="190" mass="20287" checksum="5B5B6C02B45B51C4" modified="2020-06-17" version="1">MEFTRVGKVGLRGAASLCPFHAGHRNYNSILIVPNGGQWGEWGKVESCPKGHAYGFSLKVKTEREQGVIDDDTSLNGIRLHCSSGGVVQSTVGPWGEWTEVKECPRGYLVAFALNVEAPKGPADDTAANNIRFSCGDGVILEGESPTFGTYGQWSKRCTAGAICGIQTKVEAPAPGDSTALNDVRFFCCD</sequence>
</entry>
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    <accession>A0A670J102</accession>
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        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="229"/>
            <end position="326"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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        </location>
    </feature>
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            <end position="133"/>
        </location>
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        </location>
    </feature>
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            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="336" mass="37811" checksum="FD7105D4635FBC26" modified="2020-06-17" version="1">MAPVSRSRSPAETPPSRRQRSGSSTSPSPPRSIRCKSSRPRSRSHDRGGSGGFRQRPGPPHPFGPRPGPEHYGKEQEESLRQRRLNERERIGELGAPEVWGVSPKVPDRDSDEHTPAEDEGGASKKSSSSGSSSEEEQRKKKKRKKRKAASHEEGGKKAKKRKKKHRKKKSKKRKSKKSREVSSSEDSDGDQQQEGDLWTERVRNADGEGFIGPEAPITHASQEDRPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFEKSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILAGFREMVYRKTQGKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J268</accession>
    <name>A0A670J268_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NF-kappa-B inhibitor-interacting Ras-like protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">I-kappa-B-interacting Ras-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NKIRAS2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J268"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018587.1">
        <property type="protein sequence ID" value="ENSPMRP00000017457.1"/>
        <property type="gene ID" value="ENSPMRG00000011541.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157943"/>
    <dbReference type="OMA" id="IMDRANN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032484">
        <property type="term" value="P:Ral protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010803">
        <property type="term" value="P:regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043129">
        <property type="term" value="P:surfactant homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042227">
        <property type="entry name" value="KBRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152:SF2">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="222" mass="25042" checksum="800E686E2F670B56" modified="2020-06-17" version="1">MCGCLYAYVCFHRMPSICSFLHSSSSPTDQKMGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVRELVRFYDTRGLRDGLELPKHCFSCTDGYVLVYSIDSKESFKRVEILKKEIDKSKDKKEVTIVVLGNKCDLQEQRRVDHDAVQHWAKAEKVKLWEISVADRRTLIEPFVYLASKMTQPQSKSAFPLSRKNKSSGSVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4F5</accession>
    <name>A0A670J4F5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Zinc finger and BTB domain-containing protein 48</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Telomere zinc finger-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ZBTB48</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression. In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with EP300.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670J4F5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020331.1">
        <property type="protein sequence ID" value="ENSPMRP00000019151.1"/>
        <property type="gene ID" value="ENSPMRG00000012446.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158981"/>
    <dbReference type="OMA" id="EPPGNRK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18232">
        <property type="entry name" value="BTB_POZ_ZBTB48_TZAP_KR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000657">
        <property type="entry name" value="GDNF inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001113">
        <property type="entry name" value="Zinc finger and BTB domain containing 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001117">
        <property type="entry name" value="Zinc finger and BTB domain containing 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000809">
        <property type="entry name" value="Zinc finger and BTB domain-containing 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001257">
        <property type="entry name" value="Zinc finger and BTB domain-containing 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0779">Telomere</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="23">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="217"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    <sequence length="691" mass="77809" checksum="00AB29861571B23C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
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        <scope>IDENTIFICATION</scope>
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            <end position="315"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
    <sequence length="514" mass="58952" checksum="C9ABCE02C6EB0494" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="5">Belongs to the WD repeat coronin family.</text>
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        <location>
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            <end position="111"/>
        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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        <source>
            <dbReference type="RuleBase" id="RU280818"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018737.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        <alternativeName>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Font E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="15">Orphan receptor that may have a role in planar cell polarity pathway.</text>
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    <comment type="subunit">
        <text evidence="16">Interacts (via PDZ-binding motif) with DLG1.</text>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
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        <property type="entry name" value="GPCR_2_secretin-like"/>
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        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
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    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
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        <property type="entry name" value="IG"/>
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        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
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    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
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    <feature type="signal peptide" evidence="21">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="757"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1020"/>
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        <location>
            <begin position="242"/>
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        <location>
            <begin position="323"/>
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    </feature>
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        <location>
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    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="24">
        <location>
            <begin position="751"/>
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            <begin position="25"/>
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            <begin position="33"/>
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    </feature>
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            <begin position="1228"/>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J6M9</accession>
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        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Laterata</taxon>
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            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A670J6M9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021434.1">
        <property type="protein sequence ID" value="ENSPMRP00000020188.1"/>
        <property type="gene ID" value="ENSPMRG00000013151.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="HAPVELC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="492"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1245" mass="147229" checksum="1A93C1F7FF5AC85E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J6T4</accession>
    <name>A0A670J6T4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosolic beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
            <ecNumber evidence="4">3.2.1.45</ecNumber>
            <ecNumber evidence="3">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosolic galactosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytosolic glucosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytosolic glycosylceramidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">GBA3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:14297"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.46"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:14298"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70239"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:189067"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70240"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:70241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-galactosyl-(1&lt;-&gt;1')-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:59292"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:59293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>beta-D-galactosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:43908"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:57934"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:43909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59284"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:59285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59288"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:83992"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:59289"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EC" id="3.2.1.45" evidence="4"/>
    <dbReference type="EC" id="3.2.1.46" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670J6T4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020505.1">
        <property type="protein sequence ID" value="ENSPMRP00000019314.1"/>
        <property type="gene ID" value="ENSPMRG00000012612.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160460"/>
    <dbReference type="OMA" id="YQIEGHG"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046477">
        <property type="term" value="P:glycosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF291">
        <property type="entry name" value="CYTOSOLIC BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="19">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="497" mass="55776" checksum="08FA8547A1DF21B9" modified="2020-06-17" version="1">MASALSGASSTLDSSSDSSWNPEGISFPKSFAWGASTAAYQVEGGWDADGKGPSVWDTFTHQGGDRVFKNQTGDVACGSYALWEEDLKCIKQLGLTHYRFSLSWSRLLPDGKTGFINQKGVEYYDKMIDSLLANDVTPVVTLYHFDLPQRLEDQGGWRSGATVEAFDSYAQFCFRTFGDRVKLWITINEPYVMAELGYAEGTMAPGIKELGTGAYLAAHNMIKAHAAAWHTYDRLFRKTQGGLVSIALNSDWAEPFDPNSVADQEAAKRHVAFCLDWFATPIFLNGDYPAIMKSQISAVCKRQGSPSSRLPEFTQEEKMMIKGTADFFSLNYYTSRKIKHRDNTHSPPSMSADKEAEQVTDPSWPVATGSSWLAVVPWGLRRLLEYIKDTYNHPIIYITENGFSQSDPAALDDTQRWEYFRLTLLEILKAIYVDGVQLKGYFVWSLLDNFEWTCGYRSRFGLFHVDFENPALPRVPYKSAIEYAKVIANNGLMKSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J7S4</accession>
    <name>A0A670J7S4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of cell cycle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RGCC</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670J7S4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020934.1">
        <property type="protein sequence ID" value="ENSPMRP00000019704.1"/>
        <property type="gene ID" value="ENSPMRG00000012868.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011709"/>
    <dbReference type="OMA" id="CISSVCW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070412">
        <property type="term" value="F:R-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002430">
        <property type="term" value="P:complement receptor mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072537">
        <property type="term" value="P:fibroblast activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043537">
        <property type="term" value="P:negative regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000048">
        <property type="term" value="P:negative regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001937">
        <property type="term" value="P:negative regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090272">
        <property type="term" value="P:negative regulation of fibroblast growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032967">
        <property type="term" value="P:positive regulation of collagen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000353">
        <property type="term" value="P:positive regulation of endothelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010718">
        <property type="term" value="P:positive regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901203">
        <property type="term" value="P:positive regulation of extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003331">
        <property type="term" value="P:positive regulation of extracellular matrix constituent secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900087">
        <property type="term" value="P:positive regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904707">
        <property type="term" value="P:positive regulation of vascular associated smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029252">
        <property type="entry name" value="RGCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32193">
        <property type="entry name" value="REGULATOR OF CELL CYCLE RGCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32193:SF3">
        <property type="entry name" value="REGULATOR OF CELL CYCLE RGCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15151">
        <property type="entry name" value="RGCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="163" mass="17444" checksum="EC51EEB0CAC61BE9" modified="2020-06-17" version="1">MQRPEEQQPWGALEPSGRRGAAELGPCLSADGSVSARRPPRCSLDGAPGDLAEELREFDAVLDAFSPGAQERRFPGEEPPERRRRSGSDAAQRESLFRLDGQSADSLCRNSFGFSDGKLNSPALSPAAVSTPTIASRKGKLGDTKELEDFIADLDRTLASKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J850</accession>
    <name>A0A670J850_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GTPase-activating protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Rho-type GTPase-activating protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">START domain-containing protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">START domain-containing protein 13</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">StAR-related lipid transfer protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">StAR-related lipid transfer protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">DLC1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with TAX1BP1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration. Interacts with tensin TNS1 (via N-terminus); the interaction is decreased by phosphorylation of TNS1. Interacts with TNS3 and PTEN; in resting cells, interacts with TNS3 (via C2 tensin-type domain) but, following growth factor stimulation, TNS3 and PTEN are phosphorylated which leads to weakened interaction with TNS3 and enhanced interaction with PTEN. Interacts (via C-terminus) with tensin TNS4 (via SH2 domain); the interaction is independent of tyrosine phosphorylation of DLC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028601012.1">
        <property type="nucleotide sequence ID" value="XM_028745179.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000020643.1">
        <property type="protein sequence ID" value="ENSPMRP00000019442.1"/>
        <property type="gene ID" value="ENSPMRG00000012683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604736"/>
    <dbReference type="CTD" id="10395"/>
    <dbReference type="GeneTree" id="ENSGT00950000183061"/>
    <dbReference type="OMA" id="HRGNDAI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051895">
        <property type="term" value="P:negative regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900119">
        <property type="term" value="P:positive regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04375">
        <property type="entry name" value="RhoGAP_DLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000007">
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Bellati A."/>
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                <person name="Bunikis I."/>
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
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                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
            </authorList>
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    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
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            <taxon>Euteleostomi</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Carretero M.A."/>
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                <person name="Salvi D."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
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        <property type="entry name" value="ATOS HOMOLOG PROTEIN B"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="377"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
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            <end position="227"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="288"/>
        </location>
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        <location>
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            <end position="370"/>
        </location>
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        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
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        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="574" mass="61083" checksum="E6158249760951B9" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAC9</accession>
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        <recommendedName>
            <fullName evidence="1">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JAC9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021899.1">
        <property type="protein sequence ID" value="ENSPMRP00000020619.1"/>
        <property type="gene ID" value="ENSPMRG00000013399.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160411"/>
    <dbReference type="OMA" id="WRHIHKV"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
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    </dbReference>
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        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JAT8</accession>
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        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JAT8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022627.1">
        <property type="protein sequence ID" value="ENSPMRP00000021315.1"/>
        <property type="gene ID" value="ENSPMRG00000013847.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286941"/>
    <dbReference type="OMA" id="IENQAEY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000703">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001430">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001808">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="588" mass="68105" checksum="0FC71F8D06B992E2" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC79</accession>
    <name>A0A670JC79_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Renin</fullName>
            <ecNumber evidence="4">3.4.23.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Angiotensinogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">REN</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. This protein is also found in snake venom and shown to specifically cleave human and porcine angiotensinogen into angiotensin I. It does not have general protease activity, no cleavage of alpha or beta casein. May be directly responsible for elevation of blood pressure in the victims of envenomation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.</text>
            <dbReference type="EC" id="3.4.23.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.15" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670JC79"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023273.1">
        <property type="protein sequence ID" value="ENSPMRP00000021916.1"/>
        <property type="gene ID" value="ENSPMRG00000014161.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157898"/>
    <dbReference type="OMA" id="DMQYYGE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002003">
        <property type="term" value="P:angiotensin maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042756">
        <property type="term" value="P:drinking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001823">
        <property type="term" value="P:mesonephros development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035814">
        <property type="term" value="P:negative regulation of renal sodium excretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905656">
        <property type="term" value="P:positive regulation of artery smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045777">
        <property type="term" value="P:positive regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002018">
        <property type="term" value="P:renin-angiotensin regulation of aldosterone production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000032">
        <property type="entry name" value="renin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF24">
        <property type="entry name" value="RENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="19">
        <location>
            <begin position="120"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="324"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="367"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000021916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="448" mass="49335" checksum="B44678E6E3E76BA9" modified="2020-06-17" version="1">MTLVLEAVYSAHCGVEVGEAFCVSQRKHKSIRRALLVQTKDPPNPTLHSHSGHPSFIIPFLTHFRIPLKKMPSIRETLQKMGMEVSDGFPSMEHSLYHLGEALHNVTAPTTLTNYRDTQYFGEISIGTPAQIFKVIFDTGSANLWVPSHQCSPLYSACASHARYDSSKSSTYRPNGTQIAIQYGKGHVKGFLSQDIVTFLFLVSSIQVAGIPVFQVFAEATALTNKPFNYAQFDGVLGMGYPSQAIDGVTPVFDKIMSEQILTSEVFSVYYSRNSALNTGGEIILGGSDPSYYTGDFHYLSISREGYWHIDLKGVSVGGELLFCHEGCTASVDTGTSYITGPASSVSILMKAIGATLFEEKDYIIECKKIHLLPDISFHFGDRAYILSGSAYVLQHSEYGQEFCTVAFSGFDIPPPLGPLWIMGASFIGEYYTEFDRQNNRIGFATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JC86</accession>
    <name>A0A670JC86_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glia maturation factor gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GMFG</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JC86"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023455.1">
        <property type="protein sequence ID" value="ENSPMRP00000022083.1"/>
        <property type="gene ID" value="ENSPMRG00000014363.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008920"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000024">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF4">
        <property type="entry name" value="GLIA MATURATION FACTOR GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
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        <location>
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            <end position="139"/>
        </location>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="161" mass="18532" checksum="C55BE5B397FED9BD" modified="2020-06-17" version="1">MSDSLVVCDVDPELKEKLKKFRFRKETNNAAIMMKVDKDRQLVVLEEEFQDISPEELRCELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQAAELTKVFQAHFLPLVLSIAVKRPLFGGTVPYPSAMSRCCPLLMMSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JD38</accession>
    <name>A0A670JD38_PODMU</name>
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        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Vomeronasal 2, receptor 73"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
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        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
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        <property type="entry name" value="GPCR_3_CS"/>
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        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
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        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF599">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
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        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
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        <property type="entry name" value="Periplasmic binding protein-like I"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
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    </dbReference>
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    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
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        <location>
            <begin position="524"/>
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        <location>
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            <end position="750"/>
        </location>
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        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="751" mass="85498" checksum="D0C9BBAA459655B1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JE10</accession>
    <name>A0A670JE10_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SV2A/B/C luminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Synaptic vesicle glycoprotein 2A"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2B"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pentapeptide repeat-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <sequence length="498" mass="56539" checksum="81A6D1AC5C8FA781" modified="2020-06-17" version="1">MNVVELQHGQVIYIINFTNHLSHINLATAGSKTYNAVDGGRQTAAERKHDCMGQIQGGKETMPSSIPRCSPFPLLIGWGFSMGTNYHFHSWRVFVVVCSLPCIASLVALKFMPESPRFLLEIGKHDEAWMILKQVHDTNMRAKGEPERVFTVANIKTPKQIDEFIEIQCSTGTWYQRSFVRVTTTLKQVMDNVIYCLTAQYRMNTLFLAIVWFSMALSYYGLIVWFPDMIRYYQEEAYKSREKVFNGESVKDITFNFTLENQIHRNGTYFNDKFIKMKFRDVTFEDSVFEECYFEDVTSSETFFKNCTIIKTVFFNTDLYKHKFVECKFVNATFLEQKKGCHMDFERDNDFLVYLVGFLGSLSVLPGNIISALLMDKIGRIKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTHKRATAFGILNGLCKIGAIFGNAIFASFVGITKVVPILLASSALVAGGLLALRLPETRDQVLM</sequence>
</entry>
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    <accession>A0A670JF43</accession>
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        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
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                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
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                <person name="Marsik P."/>
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                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Andersson L."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </citation>
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</entry>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
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                <person name="Bosakova Z."/>
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                <person name="Feiner N."/>
                <person name="Marsik P."/>
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                <person name="While G.M."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JG20</accession>
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        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
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        <name type="scientific">Podarcis muralis</name>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Marsik P."/>
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                <person name="Soler L."/>
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            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JG20"/>
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        <property type="protein sequence ID" value="ENSPMRP00000022554.1"/>
        <property type="gene ID" value="ENSPMRG00000014650.1"/>
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    <dbReference type="GeneTree" id="ENSGT00950000183155"/>
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        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025615">
        <property type="entry name" value="TILa_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
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    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF7">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12714">
        <property type="entry name" value="TILa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
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        <property type="match status" value="1"/>
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    <feature type="domain" description="VWFD" evidence="4">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="141" mass="15520" checksum="91B7E6DEF07CCFC0" modified="2020-06-17" version="1">LDDCSTVVPWLWNRIHSRSMSYSRGEEFWADEGCHTRCKCDSKLGKVTCTKSSCKANEKCALVNGIWGCHPTSYSTCIGTGDPHYTTFDGKKFDFMGTCIYQMAGVCSKDPTLTPFLVTVENNNRGSKAVCTPAPSANKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JGI5</accession>
    <name>A0A670JGI5_PODMU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSPMRG00000015271.1"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="129" mass="13381" checksum="1092E8F5868D0870" modified="2020-06-17" version="1">MARVSVLGVSLLENPSPFGHPLRFQVQFECGEALPHGEYAGGGRRISRARSLVPQPTLSPSQVPSHTAAARNRHPGAPTPPPRMAALGASTPGASAVALFCQPGPGSPHRGCYVGAALEMVCVCVCIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JH66</accession>
    <name>A0A670JH66_PODMU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="primary">SPMAP1</name>
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    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Bifurcata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR028027">
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    </dbReference>
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        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC691189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34221:SF2">
        <property type="entry name" value="RIKEN CDNA 1700001P01 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15075">
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="154" mass="17597" checksum="EF3D02A9724E7484" modified="2020-06-17" version="1">MTCVTRRCLQRQKEFILDGVAVDTIASSYTNLLPRLWSALPPYNAQLDIHAASYFSSPVVKSVLKKTEQTRGGTSRDGWIVDYFHIYGPGQRYLNRRNWAGAGHSPQQVAGHYWHLMDVKPVKGYNGRYGYRRNTPDLRTRSSCFGEVTCFPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJS2</accession>
    <name>A0A670JJS2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JJS2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025256.1">
        <property type="protein sequence ID" value="ENSPMRP00000023799.1"/>
        <property type="gene ID" value="ENSPMRG00000015409.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165584"/>
    <dbReference type="OMA" id="FPWISRR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:arachidonate epoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019373">
        <property type="term" value="P:epoxygenase P450 pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF389">
        <property type="entry name" value="CYTOCHROME P450 2C20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="491" mass="56480" checksum="4C3C94E355C0848A" modified="2020-06-17" version="1">MEVVGAGALLLLYLFFTVLFSSFKMYKKKSQLPPGPTPWLLLGNLLQKDVLPVYKFYTKLIDKYGPIFTVWIGPKPIVVICGYETMKDAFVNHAEEFGGRPAMPFIDRANNYRGLVNRNEAKWREVRRFTLSTLREFGMGKKTMSERIQEEALCLVEELVATQGQAFDPRRSFTCAVSNVLSSVVFGNRFDYKDPVLLENLRIVQDFMGYIRTLSMQACCSFCMLNLGHRKILADCAKMKAFIRERVESHRRTLDPQNLRDYIDCFLIRSEKKQTNPENIYSTEELVQCVFGLFIAGSTNSSTALVFSLLVMAKFPHIQAKVQQEIDEVVGANRIPGMDDWVRMPFTNAVIHETQRFEKGSLEGFPRATTCRTEFRGYIIPQSTTVVPMLTTVHYDPLQWETPEKFNPGHFLDEKGQFRKRNAFMPFSAGKRACPGEALARMELFLFFSVLLQNFTFQLVGDFKEMDVTSFHMQYKMKSACLQMQAIRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JK43</accession>
    <name>A0A670JK43_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JK43"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026889.1">
        <property type="protein sequence ID" value="ENSPMRP00000025333.1"/>
        <property type="gene ID" value="ENSPMRG00000016393.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006784"/>
    <dbReference type="OMA" id="SAGWERF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36205" checksum="75B41614D5593911" modified="2020-06-17" version="1">CLLIGSLSLPNHHHRPLPSSYGHGEDDRRIAALHELLERNTSFVYYQEGVSYSLLKMAAYGMVRAAESLLHGGADITFEGWRGTQLMLHIFIRLLLEGGELPPPALNWLFLYCPCPSGANVKATTKDGDTIFSSIISLLWKTVGGDEEEAQTVNRFCFQVTQLLMTHRAKPSKCPTYESLNLLAIYSLVLRFPLLEFGAHYNCTLHGPACWSGFSSIFEWLCSYLWWLEDDTFSADLFQKAETVLELLASSSQIIKLPSNFDINLSNCRLHRKRISDLFTSLKKLEHSPPTLKHMCRALPLPNLLKKYLLIDRSSSAEVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JK85</accession>
    <name>A0A670JK85_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JK85"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024823.1">
        <property type="protein sequence ID" value="ENSPMRP00000023382.1"/>
        <property type="gene ID" value="ENSPMRG00000015174.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154662"/>
    <dbReference type="OMA" id="GENQCET"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF39">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="90"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="877" mass="97089" checksum="0D63B7D4ECDC335D" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLB4</accession>
    <name>A0A670JLB4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JLB4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027385.1">
        <property type="protein sequence ID" value="ENSPMRP00000025803.1"/>
        <property type="gene ID" value="ENSPMRG00000016702.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="EDIMMAN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="696" mass="82454" checksum="BF5F1457FC97F366" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JLW8</accession>
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        <submittedName>
            <fullName evidence="5">Cytosolic phospholipase A2 gamma-like</fullName>
        </submittedName>
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        <name evidence="5" type="primary">LOC114582080</name>
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    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028558694.1">
        <property type="nucleotide sequence ID" value="XM_028702861.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSPMRP00000023972.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="pmua:114582080"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nuclear envelope"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:glycerophospholipid catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2 GAMMA"/>
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    </dbReference>
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        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLAc"/>
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    </dbReference>
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        <property type="entry name" value="FabD/lysophospholipase-like"/>
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    </dbReference>
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        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="4">
        <location>
            <begin position="14"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="574" mass="65026" checksum="A41B3F4CD7B4C719" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JM01</accession>
    <name>A0A670JM01_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CCN family member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cellular communication network factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Protein NOV homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CCN4</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JM01"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026470.1">
        <property type="protein sequence ID" value="ENSPMRP00000024950.1"/>
        <property type="gene ID" value="ENSPMRG00000016123.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158587"/>
    <dbReference type="OMA" id="RKIMWIN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032331">
        <property type="term" value="P:negative regulation of chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045599">
        <property type="term" value="P:negative regulation of fat cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030316">
        <property type="term" value="P:osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090303">
        <property type="term" value="P:positive regulation of wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000046">
        <property type="entry name" value="Cellular communication network factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IGFBP-like"/>
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        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IGFBP_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
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    </dbReference>
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        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0303">Gap junction</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="20">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="19">
        <location>
            <begin position="121"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="344"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
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    <sequence length="364" mass="40855" checksum="1062E5150E5725D8" modified="2020-06-17" version="1">MRWLLPWILATNGILQVFAQNITTTTTTMSPPATSTVTEAYVRTQYCKWPCECPEMPPVCPAGVSLMTDGCECCKTCAKQLGENCTEADTCDVHRGLYCDYSRDRPRYEIGVCSQIVGLDCILDGVRYKNGQSFQPNCKYNCTCIGGAVGCFPTCRDSKPPLVWCPNPKLIKLKGQCCEQWVCDDSKKIRKTSPRHISSAVYEGEIESWQKNCILHTSSWSPCSKTCGMGTSQRISNENDQCRLTKESRLCNMRPCEEDIAKHIKPGKKCLAVYRRQELMNYTLSGCVSKAAYWPKYCGVCVDNRCCTPYKSKTIDVSFECPDGTGFSKKVMWINACFCNLSCKSPNDIFADLAHYHDYSEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JMB1</accession>
    <name>A0A670JMB1_PODMU</name>
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        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JMB1"/>
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        <property type="term" value="F:catalytic activity"/>
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    </dbReference>
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            <end position="778"/>
        </location>
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            <begin position="1"/>
            <end position="50"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="990" mass="109195" checksum="6336B0B6EDE1538B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JMK0</accession>
    <name>A0A670JMK0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Replication factor A protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RPA2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598582.1">
        <property type="nucleotide sequence ID" value="XM_028742749.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSPMRT00000025678.1">
        <property type="protein sequence ID" value="ENSPMRP00000024212.1"/>
        <property type="gene ID" value="ENSPMRG00000015653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603602"/>
    <dbReference type="KEGG" id="pmua:114603602"/>
    <dbReference type="CTD" id="6118"/>
    <dbReference type="GeneTree" id="ENSGT00390000010045"/>
    <dbReference type="OMA" id="SFGNKRY"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:protein phosphatase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034502">
        <property type="term" value="P:protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000149">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="12">
        <location>
            <begin position="170"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="269" mass="29063" checksum="CE0782D0C96EA7DE" modified="2020-06-17" version="1">MWLGGAGGYDSSYGGSGYTQSPGGFASPSATQGERKSRSRSQNIVPCTVSQLLSAEQVDDAFRVRDVELSQVIVVGIIRQAEKAPTNILYKVDDMTAAPMDVRQWVDADEAGSENVVVPPGTYVKVLGHLRSFQNKKSLVAFKILPLEDMNEFTTHLLEVVNAHMILRKGNMPMSMKMPQPVGLMGMGNTSSYGGNGALPVSGLTAHQTQILNLIKSSTSAEGISLQDLQSQLRSINLPTLKKAVEFLSSEGHIYSTIDDEHFKSTDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JML5</accession>
    <name>A0A670JML5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anterior gradient 3, protein disulphide isomerase family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AGR3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AGR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028607033.1">
        <property type="nucleotide sequence ID" value="XM_028751200.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028607034.1">
        <property type="nucleotide sequence ID" value="XM_028751201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JML5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025693.1">
        <property type="protein sequence ID" value="ENSPMRP00000024227.1"/>
        <property type="gene ID" value="ENSPMRG00000015660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114607768"/>
    <dbReference type="KEGG" id="pmua:114607768"/>
    <dbReference type="CTD" id="155465"/>
    <dbReference type="GeneTree" id="ENSGT00530000063273"/>
    <dbReference type="OMA" id="PILIENM"/>
    <dbReference type="OrthoDB" id="262308at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002162">
        <property type="term" value="F:dystroglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="AGR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="anterior gradient protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF5">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025407190" evidence="3">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="164" mass="18991" checksum="0483700C1983BF93" modified="2020-06-17" version="1">MHSALGLSFMLIAVSSNFAMAIKKEKRVPQTLSRGWGDDITWVQTYEEGLYQAKQSNKPLMVIHHLEDCPYCQALKKVFVDNQEIQEMCQNNFIMLNLMHETTDKNMSPDGQYVPRIMFVDPSLTVRADITGRYSNRLYTYEPQDLPVLIENMKKALRLVQTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JP17</accession>
    <name>A0A670JP17_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gypsy retrotransposon integrase-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JP17"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026759.1">
        <property type="protein sequence ID" value="ENSPMRP00000025214.1"/>
        <property type="gene ID" value="ENSPMRG00000016319.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166555"/>
    <dbReference type="OMA" id="INIWAKE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="332"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="675" mass="74484" checksum="35D605E8221CDE2B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPL0</accession>
    <name>A0A670JPL0_PODMU</name>
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        <submittedName>
            <fullName evidence="6">Keratin 222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KRT222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028702601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JPL0"/>
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        <property type="protein sequence ID" value="ENSPMRP00000025850.1"/>
        <property type="gene ID" value="ENSPMRG00000016731.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8861979at2759"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052857">
        <property type="entry name" value="IF_Keratin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47082">
        <property type="entry name" value="KERATIN-LIKE PROTEIN KRT222"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47082:SF1">
        <property type="entry name" value="KERATIN-LIKE PROTEIN KRT222"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="149"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="282" mass="32610" checksum="255392AF2EE3CFE6" modified="2020-06-17" version="1">MELSQLLNEIRANYETLITRSQIETILSAGTQLEEATSERMSKDEEALKAARAELNEARRQWHHMQMEIDSLHAVEKGLENALRTTEQRYQTQLKHLEAEIEGLERELHKVRQGIEKQLQQHEILLNTKMRLEQEIATYRSLLEREEKRFYRSACQDRKGDKKRTTSQIAFILPSSSELKAHEIEKVEILTKQAVLNGNVAKESAEACGTIQTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCLQTKQKGLPDIEVRLVMRRSCSIPSIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JPV6</accession>
    <name>A0A670JPV6_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Dynein axonemal heavy chain 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">DNAH9</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSPMRT00000028766.1">
        <property type="protein sequence ID" value="ENSPMRP00000027118.1"/>
        <property type="gene ID" value="ENSPMRG00000016255.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154076"/>
    <dbReference type="OMA" id="WAYLVND"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
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    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000682">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000007">
        <property type="entry name" value="Dynein axonemal heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000002">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000411">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
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        <property type="entry name" value="Region D6 of dynein motor"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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            <begin position="206"/>
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        </location>
    </feature>
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        <location>
            <begin position="1284"/>
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            <begin position="2308"/>
            <end position="2425"/>
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            <begin position="2643"/>
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        <location>
            <begin position="2787"/>
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        <location>
            <begin position="3059"/>
            <end position="3402"/>
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        <location>
            <begin position="3429"/>
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            <begin position="3887"/>
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            <begin position="4039"/>
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            <begin position="4181"/>
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            <begin position="750"/>
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            <begin position="3051"/>
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        <location>
            <begin position="3274"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF03028"/>
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        <source>
            <dbReference type="Pfam" id="PF08385"/>
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        <source>
            <dbReference type="Pfam" id="PF08393"/>
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        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12777"/>
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        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027118.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="4478" mass="512407" checksum="5D1D56575FF768DB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JTU3</accession>
    <name>A0A670JTU3_PODMU</name>
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        <submittedName>
            <fullName evidence="6">Nicotinamide N-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114585649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.</text>
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        <property type="component" value="Chromosome 15"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NNMT_TEMT_trans"/>
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        <property type="entry name" value="SAM-dep_methyltransferase"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="GntF_guanitoxin"/>
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    </dbReference>
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        <property type="entry name" value="NICOTINAMIDE N-METHYLTRANSFERASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867">
        <property type="entry name" value="NNMT/PNMT/TEMT FAMILY MEMBER"/>
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        <property type="entry name" value="NNMT_PNMT_TEMT"/>
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    </dbReference>
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        <property type="entry name" value="SAM_MT_NNMT_PNMT_TEMT"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="260" mass="29437" checksum="355AD0359740EECE" modified="2020-06-17" version="1">MAFTEKDFYAGHFNPKDYLDTYYTFSSAKEHENGFLIFYLKNLHQAFILDDIKGDTLIDIGSGPTIYQFLSACESFQEIVATDYCEQNWEEMQRWLRKEPGAFDWSPVVKYVCELEGNREKWEEKEEKVRRAIKQILKCDVTQPSPLGPVSLPPADCLLSSLCLESACKDLPTFRSALKNISSLVKPGGHLVLCSILEETYYKVGQQPFSCLYLERASVEEALKGAGFAVKWLNETKINLPLSVTDAKAVCVAVAQKCQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JV87</accession>
    <name>A0A670JV87_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Myosin IE</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JV87"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028979.1">
        <property type="protein sequence ID" value="ENSPMRP00000027319.1"/>
        <property type="gene ID" value="ENSPMRG00000016787.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165572"/>
    <dbReference type="OMA" id="AHMQFYR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11827">
        <property type="entry name" value="SH3_MyoIe_If_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000010">
        <property type="entry name" value="Unconventional myosin-Ie"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035507">
        <property type="entry name" value="Ie/If_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF865">
        <property type="entry name" value="MYOSIN IEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="20"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="15">
        <location>
            <begin position="731"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="1046"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1022"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1103" mass="126433" checksum="C4197DB6E8C7211E" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JW18</accession>
    <name>A0A670JW18_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JW18"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029830.1">
        <property type="protein sequence ID" value="ENSPMRP00000028115.1"/>
        <property type="gene ID" value="ENSPMRG00000018154.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167314"/>
    <dbReference type="OMA" id="WINWSSR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="501" mass="55954" checksum="8B2DA26C34094270" modified="2020-06-17" version="1">MESPRVLEPFQPSEPHTWEDYVERFEFFAVAQGITDASKRRATFLSYCGPEIFKLAKALLAPAKLSETPLKDILACLTSHLAPTETKMAWRMEFHKRQQRAGESVSAFLAELRKLAQHCDFQDLEETLLDRFIGGLSSKKARRRIMAKEEVTLASALKEATATENYEREELDASRKAPKPQIEVVHAMDELEATPSQSPVRGVESVRQACTVHKDHRGRCPGCGGNHERKSCRFRDAMCRTCGKTGHIARVCRSAALGATGAPRLEHRRPPTANHVLKDCHYVTEINGRVVQFPAQGKAHVKVKIEGQLCDMEVDSGSGFTIVSDQTARTFFPRGKLPPLEPFPATLQSYSAGRIHVMGICAVRVQFRDKQVVLKLVIAKGSRSSLLGTDWFPALGLSIPGLNSIQTWPEMSKALCKELLVSLMKNWVVIKGPQLTSNWTLGWPQSDSNQGECHLHCNPRSKQSWINWSSREFSHPWTLLSGRLQSSHPLKQMGKSGSVQI</sequence>
</entry>
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                <person name="Marsik P."/>
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                <person name="Salvi D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0L1</accession>
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                <person name="Salvi D."/>
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                <person name="Andersson L."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
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        </citation>
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            <authorList>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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    </comment>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K3H9</accession>
    <name>A0A670K3H9_PODMU</name>
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        <recommendedName>
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        </recommendedName>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K3H9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032019.1">
        <property type="protein sequence ID" value="ENSPMRP00000030199.1"/>
        <property type="gene ID" value="ENSPMRG00000019523.1"/>
    </dbReference>
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    <dbReference type="OMA" id="LHTRTHN"/>
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        <property type="component" value="Chromosome 14"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="BRAT1"/>
    </dbReference>
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        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331:SF2">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25680" checksum="A223F9E97C7254CC" modified="2020-06-17" version="1">MDLEILSTDSEGFPRRAVIRVFIDWLRDGHPEVLADPEQFVSRAIQAVDRDLDWEVKVSGLELAKVFAAQMSGRLGLSDCPYAADSSPASQAARRLKLLEAFCRVKLFEFLFGALYDCDRPVVLKACEILLAVKSKICKDSRLEESSLELGSTSQQREEKQREELILPVGERISQDPECLILFLETTDLEGLQRSLDRSSDHLEKSPQSLLQDILSAAGNTEDNEADCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K424</accession>
    <name>A0A670K424_PODMU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Unplaced"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="434" mass="47028" checksum="CED844FC96EB25F9" modified="2020-06-17" version="1">MLYLLFLHHMGLNRLHQGSLPAPQFYNSMILPCMNSLMGSERGVMSEALPTFKAFIWILPSMNSLMGSEFVDMSEALSAFHTLIWFFPCMNCLMDSETGAPTEALSTFHALIGFLPCMNSLMPSAIGALPEALSTFHALIGFLPCMNSLMGSETAALNEALSTFHTLIGFLPCMNSLMGSETAALNEALSTFHTLIGFLPRMNSLMLSKIGAATKALPTFHALIGFLPCMNSLMHSEIGVLPEALSTFHALIGFLPCMNSLMGSETVAPTEALSTFHTLIGFLPCMNSFMFSEIGAANEALSTFHTLRGFLPCMNSLMGIEMVAPTEALSTFHALIGFLPYMNSLMESEIGAATDSLSTYNASIGFLSNAISLMGSGMGALTAALSTFQFFARLLHSADCVVFFFVLAFQFITICNGEKKGLEPQEQMERPVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4J6</accession>
    <name>A0A670K4J6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670K4J6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032986.1">
        <property type="protein sequence ID" value="ENSPMRP00000031095.1"/>
        <property type="gene ID" value="ENSPMRG00000020160.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RVT_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="445" mass="49754" checksum="F12F4C3F2BB60716" modified="2020-06-17" version="1">MANYRPVSNLPFLGKVIERVVAEQLQARLEEADHLDPFQSGFRPHHGTETALVALVDDLRRARDKGESCFLVLLDLSAAFDTIDHNILLDRLEGLGAGGTVIQWFRSFLLGRVQKVVVGDECSDPWALTCGVPQGSVLSPMLFNIYMQPLGEIIRGFGLGVHQYADDTQLYLSFKSEPVKAVTVLCECLEAVGGWMAANRLRLNPDKTEVLFLGDRRRAGVEDSLVLNGVTVPLKDQVRSLGVILDSQLSMEAQVKSVSRAAVYQLHLVRRLRPYLPADCLARVVHALVISRLDYCNALYVGLPLKVTRKLQLIQNAAARLVTGNGRRDHITPVLKDLHWLPVRFRAQFKVLVLTFKALNGLGPVYLKERLHLHHSTRTLRSSTEGLLAVPSLREAKLQGTRQRAFSVVAPSLWNALPPDVKENNNYQTFRRHLKAALFREAFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K7U8</accession>
    <name>A0A670K7U8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone H4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 14">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K7U8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034864.1">
        <property type="protein sequence ID" value="ENSPMRP00000032866.1"/>
        <property type="gene ID" value="ENSPMRG00000021308.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0164">Citrullination</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 14" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="16">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="101" mass="11189" checksum="FFCCE48D7A8D3379" modified="2020-06-17" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGTCKPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8S4</accession>
    <name>A0A670K8S4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PHYHD1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner. However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism. Does not show detectable activity towards fatty acid CoA thioesters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. PHYHD1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K8S4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036028.1">
        <property type="protein sequence ID" value="ENSPMRP00000033968.1"/>
        <property type="gene ID" value="ENSPMRG00000022035.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006287"/>
    <dbReference type="OMA" id="TSENTCF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038356"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="169" mass="19161" checksum="15888CC6D926F2A2" modified="2020-06-17" version="1">FACLLILFRQDGFLVLDQFFSSEVCEAMRAQIQKIIADMDVPPHCRTEFSTREDEQLQAQGSAEYFLTSGDKIRFFFEKGVFDGKGNRDIFYLLHLFPHSFAALHAYDSTFKQITHSSDVQVLARKLGFENPVVVQSMYIFKQPGIGGEGEVHTLPISTMKVVLNKGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8T7</accession>
    <name>A0A670K8T7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tumor protein p53 inducible nuclear protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TP53INP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nuclear body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028592302.1">
        <property type="nucleotide sequence ID" value="XM_028736469.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592303.1">
        <property type="nucleotide sequence ID" value="XM_028736470.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592304.1">
        <property type="nucleotide sequence ID" value="XM_028736471.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592305.1">
        <property type="nucleotide sequence ID" value="XM_028736472.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592306.1">
        <property type="nucleotide sequence ID" value="XM_028736473.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028592307.1">
        <property type="nucleotide sequence ID" value="XM_028736474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K8T7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035215.1">
        <property type="protein sequence ID" value="ENSPMRP00000033196.1"/>
        <property type="gene ID" value="ENSPMRG00000021525.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600412"/>
    <dbReference type="KEGG" id="pmua:114600412"/>
    <dbReference type="CTD" id="94241"/>
    <dbReference type="GeneTree" id="ENSGT00530000063829"/>
    <dbReference type="OMA" id="VGQHIHC"/>
    <dbReference type="OrthoDB" id="10041339at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048102">
        <property type="term" value="P:autophagic cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071361">
        <property type="term" value="P:cellular response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071447">
        <property type="term" value="P:cellular response to hydroperoxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072703">
        <property type="term" value="P:cellular response to methyl methanesulfonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048147">
        <property type="term" value="P:negative regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904761">
        <property type="term" value="P:negative regulation of myofibroblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029431">
        <property type="entry name" value="TP53INP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671:SF0">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14839">
        <property type="entry name" value="DOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="262" mass="30576" checksum="1236FA86A4423932" modified="2020-06-17" version="1">MFQRLNNMFVGEINNLPRQEPEFSEKEEEEWILVDFIDTCTNFSMIEEEEEVEEEEEEEEEEDIHKASPVDNSPVCSCLPPSLECLADASESCFIQFDSCPMEESWFITPPPCFTAGGLTALKVETSPLENLLIEHPSMSVYAVHNTRHSLNKTSCGGDEEEEEEEEEEETEPRDVSNPRSEAQSERGQHIRCYFAAITAHSTFLEQTKSFRPSQWIKEHNKRQYLNRNCLRRQNLTRDCYSRQLKNNGLFVHQPCQRQYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KA49</accession>
    <name>A0A670KA49_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Somatoliberin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Growth hormone-releasing factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Growth hormone-releasing hormone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GHRH</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucagon family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028590845.1">
        <property type="nucleotide sequence ID" value="XM_028735012.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028590846.1">
        <property type="nucleotide sequence ID" value="XM_028735013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KA49"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035237.1">
        <property type="protein sequence ID" value="ENSPMRP00000033215.1"/>
        <property type="gene ID" value="ENSPMRG00000021536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599559"/>
    <dbReference type="KEGG" id="pmua:114599559"/>
    <dbReference type="CTD" id="2691"/>
    <dbReference type="GeneTree" id="ENSGT00950000183154"/>
    <dbReference type="OMA" id="VMCSISS"/>
    <dbReference type="OrthoDB" id="9931004at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016608">
        <property type="term" value="F:growth hormone-releasing hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031770">
        <property type="term" value="F:growth hormone-releasing hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051428">
        <property type="term" value="F:peptide hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030252">
        <property type="term" value="P:growth hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000532">
        <property type="entry name" value="Glucagon_GIP_secretin_VIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046963">
        <property type="entry name" value="VIP/GHRH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11213">
        <property type="entry name" value="GLUCAGON-FAMILY NEUROPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11213:SF6">
        <property type="entry name" value="SOMATOLIBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00123">
        <property type="entry name" value="Hormone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00070">
        <property type="entry name" value="GLUCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00260">
        <property type="entry name" value="GLUCAGON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025352737" description="Somatoliberin" evidence="8">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glucagon / GIP / secretin / VIP family" evidence="9">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="172" mass="19679" checksum="E6AA1B30F41F535B" modified="2020-06-17" version="1">MLDRAVLLLFLHFIMCSLSSPLYPALRYSPLPISGKAVSFQLQESGPVQSHNLSVEEQEEENLLTDPAEKRMQRHADAIFTDSYRKVRGKMSAQKLLQGIVGKRLGEGNLGDEEHEFMTRRQSDSILMGSRYHQQMVLRNFLGAMLQNQRSQDINDDHLEDFVSVLTKLMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KAL6</accession>
    <name>A0A670KAL6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KAL6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035889.1">
        <property type="protein sequence ID" value="ENSPMRP00000033836.1"/>
        <property type="gene ID" value="ENSPMRG00000021949.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="PSAHEWI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="295"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1048" mass="123906" checksum="27ADD806E04A9693" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDU6</accession>
    <name>A0A670KDU6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KDU6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035845.1">
        <property type="protein sequence ID" value="ENSPMRP00000033794.1"/>
        <property type="gene ID" value="ENSPMRG00000021911.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018141"/>
    <dbReference type="OMA" id="CGENFRI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF85">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="471" mass="54114" checksum="CE4822677EBB41C8" modified="2020-06-17" version="1">MNLGKLEVVKNEMARINIDILGISELKWMGMGEFSSDDHHIYYCGQKTRKRNGVALIVNKRVAKAVLGCNLKNDRMISIRIQGRPFNITVIQVYAPTTGAEETEIDQFYEDLQDLIEVTPKKDVLLIIGDWNAKVGSQEIKGTTGKFGLGVQNEAGQRLIEFCQENKLVITNTLFQQHKRRLYTWTSPDGQHRNQIDYILCSQRWRSSIQSAKTRPGADCGSDHQLLIAKFKLKLKKVGKTTGPVRYNLSQIPYEYTVEVRNRFKDLDLVDRVPEELWMEARNIVQEAATKTIPMKRKCKKAKWLSNEALQIAEERRQAKCEGDSERYRKLNADFQRIARRDKKAFLNEQCKQIEENNRMGRTRDLFKKIGDMKGTFRTKITIIKDKSGKDLTEAEDIKKRWQEYTEELYQKDMDVSYTPGSVVAGLEPDILESEVKWALESTANNKASGSDGIPAELFKILKDDAVKVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDZ9</accession>
    <name>A0A670KDZ9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Semaphorin-6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SEMA6B</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KDZ9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035897.1">
        <property type="protein sequence ID" value="ENSPMRP00000033844.1"/>
        <property type="gene ID" value="ENSPMRG00000021952.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159170"/>
    <dbReference type="OMA" id="PTPHVDY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000009">
        <property type="entry name" value="Semaphorin 6B isoform 3 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000028">
        <property type="entry name" value="semaphorin-6A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF10">
        <property type="entry name" value="SEMAPHORIN-6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="19">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="738"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="867" mass="95721" checksum="52689B83D8B57711" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KEP8</accession>
    <name>A0A670KEP8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MAST3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A670KEP8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035307.1">
        <property type="protein sequence ID" value="ENSPMRP00000033282.1"/>
        <property type="gene ID" value="ENSPMRG00000021572.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157166"/>
    <dbReference type="OMA" id="ARICWPQ"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23075">
        <property type="entry name" value="PDZ_MAST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000457">
        <property type="entry name" value="Microtubule-associated serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
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            <begin position="783"/>
            <end position="798"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="PROSITE" id="PS51285"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033972.1"/>
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    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="584" mass="65047" checksum="19A334758BFEB5A1" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KGX8</accession>
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        <recommendedName>
            <fullName evidence="8">Phosphofurin acidic cluster sorting protein 2</fullName>
        </recommendedName>
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    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
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        <name type="synonym">Lacerta muralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PACS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KGX8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036053.1">
        <property type="protein sequence ID" value="ENSPMRP00000033992.1"/>
        <property type="gene ID" value="ENSPMRG00000022051.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183209"/>
    <dbReference type="OMA" id="AKNQNTM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057541">
        <property type="entry name" value="PACS1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF14">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25332">
        <property type="entry name" value="C2_PACS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2" evidence="5">
        <location>
            <begin position="49"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="4">
        <location>
            <begin position="500"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="103736" checksum="B93F0C7F234C8A00" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KHD9</accession>
    <name>A0A670KHD9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Perilipin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the perilipin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KHD9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038589.1">
        <property type="protein sequence ID" value="ENSPMRP00000036421.1"/>
        <property type="gene ID" value="ENSPMRG00000023503.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182920"/>
    <dbReference type="OMA" id="ISSACDM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.340">
        <property type="entry name" value="Flagellar protein FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.170">
        <property type="entry name" value="Perilipin, alpha-beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF11">
        <property type="entry name" value="PERILIPIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000036421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="436" mass="48549" checksum="A40883EAB31DCDE0" modified="2020-06-17" version="1">TKYACLMPQRDVLKRATSLPLVSSTYDLAASAYASTKENHPYVKVVLDLAEKGVKHVSDIAVSGAQPLLSKLEPQVAAASHYASKGLDKLEEKLPILHQTADQVDCNLLTIFSYVISDTQELVSSKVADAKEAVAKAVQDGKEMVVETRMGKMALSGAEAVLEKSEELLDHYLPMTEEELAKVAETTPEGVGTPLETRGYFVRLGSLSTKIQRRAYQHAVARMKAARENIRETFIQLRQAIGQVGSSLLQCVLFVNHRKKMPASFLSFCKYLGSLFMAWESKHLVSIESQTLAMSHHITQQLQAAYKNLIASIQGLPANFQLNIQLAYRNIEELHTYFTSAHSFKDLPDSILSQSQEKALKAQEYVDDILDYVLHNAPMSWLVGPFSPSPRKPDDVKPTKPEDQNKELKALTAEDKMLETNLWSHRAECLPQNKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KI10</accession>
    <name>A0A670KI10_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyridoxal kinase</fullName>
            <ecNumber evidence="9">2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Pyridoxine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">PDXK</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively. PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>pyridoxal + ATP = pyridoxal 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:10225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57761"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:25105"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25108"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16709"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:25109"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028583147.1">
        <property type="nucleotide sequence ID" value="XM_028727314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KI10"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036452.1">
        <property type="protein sequence ID" value="ENSPMRP00000034357.1"/>
        <property type="gene ID" value="ENSPMRG00000022302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596135"/>
    <dbReference type="KEGG" id="pmua:114596135"/>
    <dbReference type="CTD" id="8566"/>
    <dbReference type="GeneTree" id="ENSGT00390000003874"/>
    <dbReference type="OMA" id="HTQYGQW"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031403">
        <property type="term" value="F:lithium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pyridoxal kinase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0007">Acetylation</keyword>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0915">Sodium</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="26">
        <location>
            <begin position="96"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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            <dbReference type="ARBA" id="ARBA00004514"/>
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    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00004835"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005210"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00018134"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047310"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047377"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048524"/>
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    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="314" mass="35103" checksum="C9A35BA698D48294" modified="2020-06-17" version="1">MEEQPECRVLSIQSHVVRGYVGNKAATFPLQVLGFEIDTVNSVQFSNHTGYDHWKGQVLNSDELHELYEGLKLNNVNHYDYVLTGYTRDKSFLAMVVDIVQELKQQNSNLVYVCDPVMGDKWSGEGYMYVPKDLLPVYKDKVVPVADIITPNQFEAELLTGRKIHTEKEAIEVMDMLHNMGPETVVITSSDLQAPSGDDYLIALGSHRKTSQDGTTVTQRIRMESPKVDAVFVGTGDLFAAMLLAWTHKHPDNLKVACEKTVSAMQHVLQRTITCAKAQAGEGNKPNSAQLELRMVQSKKDIENPEIIIKATVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KIW2</accession>
    <name>A0A670KIW2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Dopamine receptor D2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DRD2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028564575.1">
        <property type="nucleotide sequence ID" value="XM_028708742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KIW2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000038402.1">
        <property type="protein sequence ID" value="ENSPMRP00000036240.1"/>
        <property type="gene ID" value="ENSPMRG00000023410.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585861"/>
    <dbReference type="KEGG" id="pmua:114585861"/>
    <dbReference type="CTD" id="1813"/>
    <dbReference type="GeneTree" id="ENSGT00940000155539"/>
    <dbReference type="OMA" id="TPLKGNC"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098691">
        <property type="term" value="C:dopaminergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097648">
        <property type="term" value="C:G protein-coupled receptor complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035240">
        <property type="term" value="F:dopamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032795">
        <property type="term" value="F:heterotrimeric G-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021984">
        <property type="term" value="P:adenohypophysis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007195">
        <property type="term" value="P:adenylate cyclase-inhibiting dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048148">
        <property type="term" value="P:behavioral response to cocaine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048755">
        <property type="term" value="P:branching morphogenesis of a nerve"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021853">
        <property type="term" value="P:cerebral cortex GABAergic interneuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051583">
        <property type="term" value="P:dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007631">
        <property type="term" value="P:feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007625">
        <property type="term" value="P:grooming behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990384">
        <property type="term" value="P:hyaloid vascular plexus regression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045776">
        <property type="term" value="P:negative regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051481">
        <property type="term" value="P:negative regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060160">
        <property type="term" value="P:negative regulation of dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050680">
        <property type="term" value="P:negative regulation of epithelial cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001223">
        <property type="term" value="P:negative regulation of neuron migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
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        <property type="entry name" value="Dopamine D2 receptor 2"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="Dopamine_D2_rcpt"/>
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        <property type="entry name" value="7tm_1"/>
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    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11 15" id="KW-0675">Receptor</keyword>
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    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
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            <begin position="47"/>
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    <evidence type="ECO:0000313" key="19">
        <source>
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    </evidence>
    <sequence length="444" mass="50091" checksum="4D321A8E68EC27F5" modified="2020-06-17" version="1">MDFQNMSSYDDSYDNQTLNGSSPGQEPPQYNFYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWGVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMITVVWVLSFAVSCPLLFGLNNTKKNECFIANPAFVVYSSIVSFYVPFIVTLLVYVQIYIVLRKRRKRVNTKRVAATNVGLDPDTEAPLKSKCTHLEDVRLCTLIMKTNGSFQLHKRRVDAVNHMEEMEMATSTSPAEKTKHKPLVPSNDEVAMPAASNLCANATLRSPTDGPPKVEKNGHTVDNPKAAKIFEIQTMPNGKTRTSLKTMSRRKFSQQKEKKATQMLAIVLGVFIICWLPFFITHILNMHCNCGIPPALYNAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKF5</accession>
    <name>A0A670KKF5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS2m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S2, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MRPS2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for mitoribosome formation and stability, and mitochondrial translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028570560.1">
        <property type="nucleotide sequence ID" value="XM_028714727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KKF5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037335.1">
        <property type="protein sequence ID" value="ENSPMRP00000035212.1"/>
        <property type="gene ID" value="ENSPMRG00000022793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588927"/>
    <dbReference type="CTD" id="51116"/>
    <dbReference type="GeneTree" id="ENSGT00390000017382"/>
    <dbReference type="OMA" id="PYIFMEK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000026">
        <property type="entry name" value="28S ribosomal protein S2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="270" mass="30719" checksum="9981C61BD0609E56" modified="2020-06-17" version="1">MMAAPRLLRGAAAVLPRLCSLGAWTKTPPTLQRLYTTLPATSPEEAPTVDYDRLLGEPLKNPDFFNVQELFSLKDLFDARVHLGHKKGCRHRFMEPYIFGCRLDQDIINLEQTMVHLQLALNFMAHVAYRKGIILFISRNRQFSHRIEATAKECGEYAHTRYWQGGLMTNADVQYGLGVRLPDLIILTNTLTNVFEPHMAIRDAAKMNIPTVGVVDTNCNPTLITYPIPGNDDTPSAVELYLRLFKMTIMRAKDKRRQMEVLCRGQDKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KKX2</accession>
    <name>A0A670KKX2_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 121B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TMEM121B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028601421.1">
        <property type="nucleotide sequence ID" value="XM_028745588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KKX2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000037485.1">
        <property type="protein sequence ID" value="ENSPMRP00000035357.1"/>
        <property type="gene ID" value="ENSPMRG00000022874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114604953"/>
    <dbReference type="KEGG" id="pmua:114604953"/>
    <dbReference type="CTD" id="27439"/>
    <dbReference type="GeneTree" id="ENSGT00940000154822"/>
    <dbReference type="OMA" id="HRVVSNQ"/>
    <dbReference type="OrthoDB" id="5964337at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026624">
        <property type="entry name" value="CECR6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000035357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="520" mass="53421" checksum="270FAB22463CC19C" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HL51</accession>
    <name>A0A670HL51_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HL51"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000582.1">
        <property type="protein sequence ID" value="ENSPMRP00000000554.1"/>
        <property type="gene ID" value="ENSPMRG00000000418.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286944"/>
    <dbReference type="OMA" id="IKQEPCC"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001450">
        <property type="entry name" value="zinc finger protein 774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="369" mass="42484" checksum="EBC225A024CDBBB9" modified="2020-06-17" version="1">MEEEIGDQVEPEKQEGNQTEMWMNESVTWQGDNFPEILVQQGKQKGQRKNVCPVCGKSFNRKSDLNVHWRIHTGEKPYKCLECGKSFRQLASFSSHQRIHTGERPYKCSECGKGFYDKSSLVIHQRIHTGEKPYQCLVCGKGFHQSFGLTSHQRIHTGEKPYVCSECGKSFYDKPHLTRHQRIHTGEKPYTCTECGKSFSQITSFTSHQRIHTGERPFMCSHCGKSFYDKSNLLTHQRIHTGERRYECQECGKTFSQKKSLTSHQSIHTGEKPYQCPECGKYFRQQTDLTSHQRIHTGVRPFQCLECGKRFYRKADLNRHQKVHAGVGRPIIAWSVEMASDGVSILCPLGEFTEESQCMASEIKQEPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HLU1</accession>
    <name>A0A670HLU1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Paired box 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAX2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028584798.1">
        <property type="nucleotide sequence ID" value="XM_028728965.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A670HLU1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000487.1">
        <property type="protein sequence ID" value="ENSPMRP00000000461.1"/>
        <property type="gene ID" value="ENSPMRG00000000343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597004"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157412"/>
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        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001658">
        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072207">
        <property type="term" value="P:metanephric epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000378">
        <property type="term" value="P:negative regulation of reactive oxygen species metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050679">
        <property type="term" value="P:positive regulation of epithelial cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of metanephros size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
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    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022130">
        <property type="entry name" value="Pax2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF19">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12403">
        <property type="entry name" value="Pax2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000461.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="512" mass="55227" checksum="633BF4D9FB78A960" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMX7</accession>
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            <fullName evidence="11">Cysteine and serine rich nuclear protein 2</fullName>
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        <name evidence="11" type="primary">CSRNP2</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_028721490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HMX7"/>
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        <property type="protein sequence ID" value="ENSPMRP00000000332.1"/>
        <property type="gene ID" value="ENSPMRG00000000255.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00950000183072"/>
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    <dbReference type="OrthoDB" id="5946974at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF6">
        <property type="entry name" value="CYSTEINE_SERINE-RICH NUCLEAR PROTEIN 2"/>
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    </dbReference>
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        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
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    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="62"/>
            <end position="280"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="536" mass="58688" checksum="9FFA6E7B9CBCC474" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HMY8</accession>
    <name>A0A670HMY8_PODMU</name>
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        <recommendedName>
            <fullName evidence="6">Lysophosphatidic acid phosphatase type 6</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ACP6</name>
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    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:39835"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:75757"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:39836"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:15018"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028582721.1">
        <property type="nucleotide sequence ID" value="XM_028726888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HMY8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000000694.1">
        <property type="protein sequence ID" value="ENSPMRP00000000660.1"/>
        <property type="gene ID" value="ENSPMRG00000000501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114595968"/>
    <dbReference type="KEGG" id="pmua:114595968"/>
    <dbReference type="CTD" id="51205"/>
    <dbReference type="GeneTree" id="ENSGT00940000158408"/>
    <dbReference type="OMA" id="SWPPFTS"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052642">
        <property type="term" value="F:lysophosphatidic acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001311">
        <property type="term" value="P:lysobisphosphatidic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000030">
        <property type="entry name" value="Lysophosphatidic acid phosphatase type 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF202">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID PHOSPHATASE TYPE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000000660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="412" mass="46257" checksum="C7046AA93C9AB7F4" modified="2020-06-17" version="1">MSLWARVGILGTLAYCVASKRRALAEPRRSKAPRGSGDGDDPLELKLVQVLFRHGARTPLRPIPDVEQVAWDPALLETPAETKFDYTVTNLAGGPRPYSPFEESYKKTVLKGGVNAGQLTKVGMQQTFALGKRLRRRYIEETHFLSPAFKPSEVFVRSTNIVRNLESTRCLLAGLFQQQKEGPITIVTDEADSEILYPNPVNCHGLKVMNRERLANVLLLQPGIAEDLKTIKEKMGLDSKNGADFFLLFDNIFAEQAHNLPSCPILKSFMELIEQRAIDSLLYVTKLNLRETLKMSVGPLLNIIEKNIKAAMNPSSPEIKARKLALYAIHDVTLFPLLLALGVFDSKWPPYAADMTIELYQRSKDWFIRLLYNGEELVPRGCRAGLCPLEDFLNALSTYSANPEEYKMLCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HPZ3</accession>
    <name>A0A670HPZ3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670HPZ3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002004.1">
        <property type="protein sequence ID" value="ENSPMRP00000001884.1"/>
        <property type="gene ID" value="ENSPMRG00000001391.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160340"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000001884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="132" mass="15185" checksum="98E52865A86980A1" modified="2020-06-17" version="1">MWEQFLGTWKPVSTEKFDDYLKELGTDFATRKMAGVAMPNVIVSRNGDVITIKRDSSLRNTEISFKGGGRSLMRPLEMTGKLRALNGMRKETATKRRRADGKLVVECEMNNLICTRKRRRAESHGDRDFPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HSP8</accession>
    <name>A0A670HSP8_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fatty acid desaturase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114600538</name>
        <name evidence="14" type="synonym">FADS3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; polyunsaturated fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028592632.1">
        <property type="nucleotide sequence ID" value="XM_028736799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HSP8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000002254.1">
        <property type="protein sequence ID" value="ENSPMRP00000002117.1"/>
        <property type="gene ID" value="ENSPMRG00000001549.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600538"/>
    <dbReference type="GeneTree" id="ENSGT00950000182990"/>
    <dbReference type="OMA" id="QWWKNKH"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00658"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000010">
        <property type="entry name" value="Delta-6 fatty acyl desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF12">
        <property type="entry name" value="ACYL-COA 6-DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="444" mass="52135" checksum="FF76118738C71979" modified="2020-06-17" version="1">MGKGEEQGGMCAEREAPSPSYTWEEIQKHNVHTDKWLVIERKVYNITQWAKRHPGGLRVISHYAGEDATDAFKAFHPDPVFVRKFLKPLLIGELAPGEPSQDRGQNSQLVEDFRALRKTAEDMNLFQADPVFFSLYLGHILVMEALAWLMVSYCGTNWITTFLLAIILAVSQAQAGWLQHDFGHLSVFKKSTWNHVVHKFVIGHLKGASANWWNHRHFQHHAKPNIFKKDPDVNMVHLFVLGDTQPVEYGKKKLKYFPYNHQHEYFFFVFPPLLIPVYFQMQIFMTMFRHKFWADLAWAFSYYLRYFTLYIPFYGVLGSLCLLTFVRFMESHWFVWVTQMNHIPMEIDNDKHRDWLSAQLAATCNIEQSFFNDWFSGHLNFQIEHHLFPTMPRHNYHKIAPLVRSLCAKYNVPYEEKPIMKAFSDIVGSLKKSGALWLDAYLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTG4</accession>
    <name>A0A670HTG4_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">VPS37C subunit of ESCRT-I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">VPS37C</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028593297.1">
        <property type="nucleotide sequence ID" value="XM_028737464.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028593307.1">
        <property type="nucleotide sequence ID" value="XM_028737474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HTG4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003035.1">
        <property type="protein sequence ID" value="ENSPMRP00000002831.1"/>
        <property type="gene ID" value="ENSPMRG00000002044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600788"/>
    <dbReference type="KEGG" id="pmua:114600788"/>
    <dbReference type="CTD" id="55048"/>
    <dbReference type="GeneTree" id="ENSGT00950000183012"/>
    <dbReference type="OMA" id="PMYRAGY"/>
    <dbReference type="OrthoDB" id="10004364at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039702">
        <property type="term" value="P:viral budding via host ESCRT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000003">
        <property type="entry name" value="vacuolar protein sorting-associated protein 37B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="11">
        <location>
            <begin position="79"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="366" mass="39868" checksum="E97E0CDE9B704403" modified="2020-06-17" version="1">MMMAFRDKTVDELKELQDNSEEIERLALESNEVQDVQLEREMALATNRSLAERNLKFQEPLETGRANLSDKYQELQKLVEQCQEQKAKLEKFSAAMQPGTLLNLLEVEGQKIEEESEMMAEKFLEGEVPLETFLEQFSSMRKLSHLRRVKVEKLQEVLRKSQSSQEPARSSAFNHQHPSTMPSGPANQQPQNSLAGGLPYPLPYSLSPCMPTGPSAHGALQPASFPGAPVMVGHVTSSQPSSQPPFPNRSPSGPGYPPVSSSSSLPQPQVGDPSASSGYSWSPSRAPPSGPGYPQPPVRALSTGPGYPQSPFFPPAGRPQCPYPTQPPVPSYPIPSQPPYPTGPSPPFGYPPPPPLPPQGPSWPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HTX2</accession>
    <name>A0A670HTX2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC114596155</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028583229.1">
        <property type="nucleotide sequence ID" value="XM_028727396.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583306.1">
        <property type="nucleotide sequence ID" value="XM_028727473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HTX2"/>
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        <property type="protein sequence ID" value="ENSPMRP00000002522.1"/>
        <property type="gene ID" value="ENSPMRG00000001824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596155"/>
    <dbReference type="KEGG" id="pmua:114596155"/>
    <dbReference type="GeneTree" id="ENSGT00940000157224"/>
    <dbReference type="OMA" id="WPANPTW"/>
    <dbReference type="OrthoDB" id="8942303at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:disaccharide binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell differentiation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:eosinophil chemotaxis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:innate immune response"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:macrophage chemotaxis"/>
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        <property type="term" value="P:monocyte chemotaxis"/>
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        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive chemotaxis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of calcium ion import"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF26">
        <property type="entry name" value="GALECTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0389">IgE-binding protein</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10 19" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Galectin" evidence="21">
        <location>
            <begin position="151"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="81"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022972"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="284" mass="28914" checksum="6A375FCAE15A825E" modified="2020-06-17" version="1">MSDGFSLSDALSGGANNPNANPNAQPNPWGNQPGTFPGYPGAFPGPYPGAPGAYPGAPGAYPGAPGAYPGAPGAYPGAPQAGGGYPGGPPQPGGFPSAPGMVPPGASGMYPGPGQPPSGGGAQPTAPQGGPGFPPSVPSGGAPSGPLKVPCDIPLPAGLQPRTLLTIVGTVNPRATCIKVDLKKGNDIALHFNPRFNEDGRKVIVCNTMLHNTWGKEDRTAPRFPFEAGKPFKIQILCEADHLKIAVNDAHLMQYNHRIKELNQINKLCINGDITLTSVTPTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HUQ3</accession>
    <name>A0A670HUQ3_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Poly(rC) binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PCBP3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028559208.1">
        <property type="nucleotide sequence ID" value="XM_028703375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670HUQ3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000003015.1">
        <property type="protein sequence ID" value="ENSPMRP00000002812.1"/>
        <property type="gene ID" value="ENSPMRG00000002029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582331"/>
    <dbReference type="CTD" id="54039"/>
    <dbReference type="GeneTree" id="ENSGT00940000162768"/>
    <dbReference type="OMA" id="MQVVPYS"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22519">
        <property type="entry name" value="KH-I_PCBP3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22522">
        <property type="entry name" value="KH-I_PCBP3_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000002">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000003">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000005">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="240"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000002812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="319" mass="33779" checksum="4E6FD703802F1CE6" modified="2020-06-17" version="1">MESKVSEGGLNVTLTIRLLMHGKEVGSIIGKKGETVKKMREESGARINISEGNCPERIVTITGPTDAIFKAFAMIAYKFEEDIINSMSNSTATSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPNSTERAVTISGTPDAIIQCVKQICVVMLESPPKGATIPYRPKPASTPVIFAGGQAYTIQGQYAIPHPDQLTKLHQLAMQQTPFTPLGQTTPAFPGLDASPPASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIANATEGSSERQITITGTPANISLAQYLINARLTSEVTGMGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670HXF6</accession>
    <name>A0A670HXF6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I5G8</accession>
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            <fullName evidence="6">Acylamino-acid-releasing enzyme</fullName>
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        <name type="scientific">Podarcis muralis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
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                <person name="Wallerman O."/>
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                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
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        </reaction>
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        <text evidence="4">Homotetramer.</text>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:omega peptidase activity"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
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        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
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    </dbReference>
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        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I6I1</accession>
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        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
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        <name evidence="10" type="primary">CLDN10</name>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Brejcha J."/>
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                <person name="Wallerman O."/>
                <person name="Pereira P."/>
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                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
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        <subcellularLocation>
            <location evidence="8">Cell junction</location>
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        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
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    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028728315.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000155232"/>
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    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043269">
        <property type="term" value="P:regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003554">
        <property type="entry name" value="Claudin10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01383">
        <property type="entry name" value="CLAUDIN10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025513856" description="Claudin" evidence="9">
        <location>
            <begin position="24"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="232" mass="24740" checksum="A922C9F2A7B61217" modified="2020-06-17" version="1">MANSSAEILAFLLVISGWVLVSSTLPTDYWKVSTIDGTVITTATFWANLWKTCVTDSTGVSNCKDFPSMLALDGYIQACRGLMIAAVCLGFFGSVFALVGMKCTKIGGSDQTKAKIACLAGFIFILCGLCAMAGCSLYANRITSEFFDPTYIAQKYELGAALFIGWAGSALCIIGGSIFCFSIAENNKTPRMGYTYNRAASAMTIGTKGCNGSADLKMPRAPPKHFDKNAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I837</accession>
    <name>A0A670I837_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 18 open reading frame 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">C18orf21</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0711 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670I837"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008455.1">
        <property type="protein sequence ID" value="ENSPMRP00000007906.1"/>
        <property type="gene ID" value="ENSPMRG00000005336.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013383"/>
    <dbReference type="OMA" id="HKGVNRD"/>
    <dbReference type="OrthoDB" id="10049098at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029779">
        <property type="entry name" value="Rmp24-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31402">
        <property type="entry name" value="UPF0711 PROTEIN C18ORF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31402:SF2">
        <property type="entry name" value="UPF0711 PROTEIN C18ORF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15719">
        <property type="entry name" value="Rmp24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000007906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="202" mass="22841" checksum="A57B4F45B044186E" modified="2020-06-17" version="1">MGRPHYLEDAARQLADTCPAQARFLLWTLSNREDKTQDSVNQVCHYCFQFLLPDNVRVRLMPKKRVTPQIQKLLNREAKGYKLNLKQTKLLKKYKEAKNVLLVTCSACGKTTRHSGKSREGLGRKASAGKSSNKTTSVTHHHSGSNRGTPNSRTSSGQSTPRSSSRTQRNIKDHFAQLKKLLHLEENKKSNKGDLKNFLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670I8W4</accession>
    <name>A0A670I8W4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CDH6</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Cell membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028593751.1">
        <property type="nucleotide sequence ID" value="XM_028737918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670I8W4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000008683.1">
        <property type="protein sequence ID" value="ENSPMRP00000008123.1"/>
        <property type="gene ID" value="ENSPMRG00000005501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600993"/>
    <dbReference type="KEGG" id="pmua:114600993"/>
    <dbReference type="CTD" id="1004"/>
    <dbReference type="GeneTree" id="ENSGT00940000154673"/>
    <dbReference type="OMA" id="RQDLHRS"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000297">
        <property type="entry name" value="Cadherin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000009">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000012">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000017">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000014">
        <property type="entry name" value="Cadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000006">
        <property type="entry name" value="Cadherin-9 preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF322">
        <property type="entry name" value="CADHERIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025362012" description="Cadherin-6" evidence="18">
        <location>
            <begin position="22"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="79"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="160"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="269"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="384"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="488"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="790" mass="88643" checksum="370E92E52A05DFA7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IA82</accession>
    <name>A0A670IA82_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpin family B member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SERPINB5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family. Ov-serpin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028593701.1">
        <property type="nucleotide sequence ID" value="XM_028737868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IA82"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009381.1">
        <property type="protein sequence ID" value="ENSPMRP00000008780.1"/>
        <property type="gene ID" value="ENSPMRG00000005917.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600977"/>
    <dbReference type="KEGG" id="pmua:114600977"/>
    <dbReference type="CTD" id="5268"/>
    <dbReference type="GeneTree" id="ENSGT00940000160674"/>
    <dbReference type="OMA" id="FITNWMK"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001533">
        <property type="term" value="C:cornified envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016528">
        <property type="term" value="C:sarcoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050678">
        <property type="term" value="P:regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000014">
        <property type="entry name" value="Serpin family B member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000240">
        <property type="entry name" value="Serpin_B9/Maspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF55">
        <property type="entry name" value="SERPIN B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00676">
        <property type="entry name" value="MASPIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="13"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000008780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="375" mass="42585" checksum="E8942F16E65E365E" modified="2020-06-17" version="1">MDALQVANTAFAVDVLKKLAEKDKTANIIFAPLCTSTSLALAYKAAKGDTATQMKQGLHLEDVKDVPFGFQTITTDAAKLSSFYPLKMVKRLFVEKSLNPTMEFVSSVKRPFPSELELVDFKEKTEDTRLQINKSVSDLTDGKMENILIEGTVNDQTKILLINAAYFVTNWMKRFPEAQTKECPFRINKTETKPVQMMNLEATFCLGYVNDLKVKILELPCHNKHMSMLILLPKDIEDDTTGLEQLEKELTPEKLIQWTNPSMMANTKVNVFLPKFKVDGEYDFKPILESLGMTNMFDESASDFSEMSETKGVVLSQVIHKVSLEVIEEGAESLDVPGYRILQHKDEFKADHPFFFFFRHTKTRNIVFAGRFCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ICB9</accession>
    <name>A0A670ICB9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A670ICB9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000009915.1">
        <property type="protein sequence ID" value="ENSPMRP00000009289.1"/>
        <property type="gene ID" value="ENSPMRG00000006243.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163653"/>
    <dbReference type="OMA" id="PIQSQMW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17958">
        <property type="entry name" value="DEADc_DDX43_DDX53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="143"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="330"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000009289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="514" mass="58155" checksum="EAA1465E965F7562" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IEB0</accession>
    <name>A0A670IEB0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cell division cycle 5-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CDC5L</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028577707.1">
        <property type="nucleotide sequence ID" value="XM_028721874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IEB0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000010748.1">
        <property type="protein sequence ID" value="ENSPMRP00000010086.1"/>
        <property type="gene ID" value="ENSPMRG00000006739.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114593487"/>
    <dbReference type="KEGG" id="pmua:114593487"/>
    <dbReference type="CTD" id="988"/>
    <dbReference type="GeneTree" id="ENSGT00550000074922"/>
    <dbReference type="OMA" id="KMGMAGE"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071987">
        <property type="term" value="F:WD40-repeat domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000091">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="15">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="15">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="16">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="409"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="803" mass="91986" checksum="3450DD44E6AEC8E6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IF89</accession>
    <name>A0A670IF89_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myozenin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MYOZ3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myozenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IF89"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011366.1">
        <property type="protein sequence ID" value="ENSPMRP00000010655.1"/>
        <property type="gene ID" value="ENSPMRG00000007082.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSPMRT00000011373.1">
        <property type="protein sequence ID" value="ENSPMRP00000010661.1"/>
        <property type="gene ID" value="ENSPMRG00000007082.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183027"/>
    <dbReference type="OMA" id="WIQVMPE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051373">
        <property type="term" value="F:FATZ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031433">
        <property type="term" value="F:telethonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008438">
        <property type="entry name" value="MYOZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15941">
        <property type="entry name" value="MYOZENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15941:SF15">
        <property type="entry name" value="MYOZENIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05556">
        <property type="entry name" value="Calsarcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000010655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="270" mass="29997" checksum="854554AAA7D25AED" modified="2020-06-17" version="1">MFPLMHSDHSREPRTRVQTIMGELTDGEALVELDLGKKVSIPQDLMMEELSLPINKGSRLYQKRQRRVQNFVLEHPSGYRIISNVSGGGGGSHADYDGVGMSEGQSIHNAEGKENYQAGLHEAASGKATPPKVPKKTNKVLRMSKALNPNAIAPGYSGPLSGVPPEKFNRTAIPKGYQSPWREFLSSEDYQIDHETRLPEPPRKVNSFDVRSFNRTPTPFGGPLLNDVILGYEMNEAPTDMSSLELMLNRPSFNRAPRGWIQAMPESEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IGU7</accession>
    <name>A0A670IGU7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM70</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028592517.1">
        <property type="nucleotide sequence ID" value="XM_028736684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IGU7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000012067.1">
        <property type="protein sequence ID" value="ENSPMRP00000011295.1"/>
        <property type="gene ID" value="ENSPMRG00000007559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114600502"/>
    <dbReference type="KEGG" id="pmua:114600502"/>
    <dbReference type="CTD" id="54968"/>
    <dbReference type="GeneTree" id="ENSGT00390000018710"/>
    <dbReference type="OMA" id="TTFYVKR"/>
    <dbReference type="OrthoDB" id="156886at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030061">
        <property type="term" value="C:mitochondrial crista"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140260">
        <property type="term" value="F:mitochondrial proton-transporting ATP synthase complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="255" mass="28868" checksum="2E22F28A9B37E3D8" modified="2020-06-17" version="1">MLLRAGVRLRAASLRLWLRGAGRCHALLLTERRPGVLEPGRRSVAALCRPRLGWRGAPGSLSAIVGSEQVPSLHVQPLRCFSTSSLHEDSEHGRLVYRGNLAKAVLGVKFFSYSTSMFSLSMIPIIFYKTGVPVDNLPLQVMFYSVIGFFTFVTPVTLHLITKGYIIRLYHKPETDTYTAITYNAILAEKKTVFHQKDVKVPDISKMFTTFYAKTKSMLVNPMLFQYPQDYNHLMGYDKPFTFDFEESKESSEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHJ8</accession>
    <name>A0A670IHJ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone deacetylase</fullName>
            <ecNumber evidence="3 12">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">HDAC7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A670IHJ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000011830.1">
        <property type="protein sequence ID" value="ENSPMRP00000011074.1"/>
        <property type="gene ID" value="ENSPMRG00000007354.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159065"/>
    <dbReference type="OMA" id="WPLSWTR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140694">
        <property type="term" value="P:membraneless organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032703">
        <property type="term" value="P:negative regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901223">
        <property type="term" value="P:negative regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10008">
        <property type="entry name" value="HDAC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000002">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046949">
        <property type="entry name" value="HDAC4/5/7/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364:SF13">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364">
        <property type="entry name" value="HISTONE DEACETYLASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037911">
        <property type="entry name" value="HDAC_II_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="614"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="170"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="453"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="542"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Contributes to catalysis" evidence="15">
        <location>
            <position position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1044" mass="113376" checksum="506B254748C854EC" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IHP3</accession>
    <name>A0A670IHP3_PODMU</name>
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        <submittedName>
            <fullName evidence="18">Sialic acid-binding Ig-like lectin 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114603488</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
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    </organism>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
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            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.</text>
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        <property type="nucleotide sequence ID" value="XM_028742519.1"/>
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        <property type="gene ID" value="ENSPMRG00000007653.1"/>
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    <dbReference type="KEGG" id="pmua:114603488"/>
    <dbReference type="GeneTree" id="ENSGT01150000286907"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:sialic acid binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="contactin-3 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CD80_C2-set"/>
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        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="Ig_V-set"/>
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    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF125">
        <property type="entry name" value="SIALIC ACID-BINDING IG-LIKE LECTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2-set_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07679">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="178"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="289"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="398"/>
            <end position="465"/>
        </location>
    </feature>
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        <location>
            <begin position="664"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000011428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="730" mass="80455" checksum="224D06DF6673538B" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IKY1</accession>
    <name>A0A670IKY1_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho guanine nucleotide exchange factor 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARHGEF16</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
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</entry>
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                <person name="Bunikis I."/>
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                <person name="Marsik P."/>
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                <person name="While G.M."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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                <person name="Perez I de Lanuza G."/>
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                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
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</entry>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035778">
        <property type="entry name" value="SPRY_hnRNP_U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381:SF41">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SAP" evidence="14">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="13">
        <location>
            <begin position="190"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="540"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="638"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="749" mass="83389" checksum="D752F5711F476CDF" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INV8</accession>
    <name>A0A670INV8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sulfotransferase</fullName>
            <ecNumber evidence="20">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CHST2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-O-{N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + 3'-phosphoadenylyl sulfate = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67860"/>
            <dbReference type="Rhea" id="RHEA-COMP:17365"/>
            <dbReference type="Rhea" id="RHEA-COMP:17366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:176490"/>
            <dbReference type="ChEBI" id="CHEBI:176491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>3-O-{N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + 3'-phosphoadenylyl sulfate = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67856"/>
            <dbReference type="Rhea" id="RHEA-COMP:17368"/>
            <dbReference type="Rhea" id="RHEA-COMP:17369"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:176489"/>
            <dbReference type="ChEBI" id="CHEBI:176492"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:67857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>3-O-{beta-D-galactosyl-(1-&gt;3)-[N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + 3'-phosphoadenylyl sulfate = 3-O-{beta-D-galactosyl-(1-&gt;3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67868"/>
            <dbReference type="Rhea" id="RHEA-COMP:14419"/>
            <dbReference type="Rhea" id="RHEA-COMP:17367"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:139605"/>
            <dbReference type="ChEBI" id="CHEBI:176494"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:67869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-{beta-D-galactosyl-(1-&gt;3)-[N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + 3'-phosphoadenylyl sulfate = 3-O-{beta-D-galactosyl-(1-&gt;3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1-&gt;6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67864"/>
            <dbReference type="Rhea" id="RHEA-COMP:14420"/>
            <dbReference type="Rhea" id="RHEA-COMP:17370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:139607"/>
            <dbReference type="ChEBI" id="CHEBI:176493"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:67865"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18">Protein modification; carbohydrate sulfation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homodimer; disulfide-linked. Homodimerization is not essential for enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="20"/>
    <dbReference type="RefSeq" id="XP_028587051.1">
        <property type="nucleotide sequence ID" value="XM_028731218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670INV8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000013814.1">
        <property type="protein sequence ID" value="ENSPMRP00000012937.1"/>
        <property type="gene ID" value="ENSPMRG00000008667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114597846"/>
    <dbReference type="KEGG" id="pmua:114597846"/>
    <dbReference type="CTD" id="9435"/>
    <dbReference type="GeneTree" id="ENSGT00940000161292"/>
    <dbReference type="OMA" id="DYKWHKG"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903238">
        <property type="term" value="P:positive regulation of leukocyte tethering or rolling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000765">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016469">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF3">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005883">
        <property type="entry name" value="Carbohydrate_sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="21">
        <location>
            <begin position="236"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000012937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="441" mass="49828" checksum="D5E18BE9F1BE997B" modified="2020-06-17" version="1">MKVFRRKALVLCLGYVLLLLLTMLNLLDYKWHKGPQQCSEPSPARRTPYPQQLPYYTYQSRSDTRALYGPPVPLARKRQLVYIFTTWRSGSSFFGELFNQNPEVFFLYEPVWHVWQKLYPGDAVSLQGAARDMLSSLYRCDLSVFQLYSTAGVGKNLTTLGIFGAATNKVICSSPLCPAYRKEVVGMVDDKLCKKCPPQQLHLLQEECLKYHTLVIKGVRVFDIGVLAPLMQDPSLALKVIHLVRDPRAVASSRIKSRHGLIRESLQVVRSRDPRIHRMPFLDAGHKLNSKKEGGGGSDYHALGAMEVICGSMAKTLQTALRPPDWLKGNYMAVRYEDLVVDPIKTLRQVYGFVNLAVSPEMEKFALNMTSGPGYSSKPFVVSARNASQAVNAWRTALSFLQIKQVEEYCHQPMAILGYERVNGPEEVKDLSKTLLRKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670INZ8</accession>
    <name>A0A670INZ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Steroid receptor RNA activator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Steroid receptor RNA activator protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SRA1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SRA1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670INZ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014143.1">
        <property type="protein sequence ID" value="ENSPMRP00000013249.1"/>
        <property type="gene ID" value="ENSPMRG00000008858.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001803"/>
    <dbReference type="OMA" id="VPGIQHD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002153">
        <property type="term" value="F:steroid receptor RNA activator RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045662">
        <property type="term" value="P:negative regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000006">
        <property type="entry name" value="steroid receptor RNA activator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040243">
        <property type="entry name" value="Steroid_recept_RNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18834">
        <property type="entry name" value="STEROID RECEPTOR RNA ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18834:SF2">
        <property type="entry name" value="STEROID RECEPTOR RNA ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SRA1/Sec31" evidence="18">
        <location>
            <begin position="93"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="61"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="255" mass="27718" checksum="7934B1E3A4D637B4" modified="2020-06-17" version="1">MRAWPPLPFPLRIRPATSGAGKRLRARLAEGEAMAELYVKPGNRERGWNDPPQFSYGLQQLQASGAGGGGGGGKRGILTRRPAAAPGAAPPPPPPHGPALPPPPVGLPPPGLPSRSVRVDATNQPVTEAGEDCHVEDVLAPLNEALANCRRSVPKQVCDDISKRLGILQQMWVQGKLSAPVRKGMKILTQELKKRHWDAADEIHRSLIVDHVTEVSQWMVGVKRLIAETRNLHTEDLATEDYEQKVETSLEPECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQU9</accession>
    <name>A0A670IQU9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">KH domain-containing, RNA-binding, signal transduction-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Src-associated in mitosis 68 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">KHDRBS1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KHDRBS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028594844.1">
        <property type="nucleotide sequence ID" value="XM_028739011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IQU9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015345.1">
        <property type="protein sequence ID" value="ENSPMRP00000014370.1"/>
        <property type="gene ID" value="ENSPMRG00000009579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114601663"/>
    <dbReference type="KEGG" id="pmua:114601663"/>
    <dbReference type="CTD" id="10657"/>
    <dbReference type="GeneTree" id="ENSGT00940000155718"/>
    <dbReference type="OMA" id="GYDENYT"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:signaling adaptor activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of RNA export from nucleus"/>
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        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
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        <property type="term" value="P:regulation of apoptotic process"/>
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        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:T cell receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22468">
        <property type="entry name" value="KH-I_KHDRBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH RNA binding domain containing, signal transduction associated 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
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        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
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        <property type="entry name" value="KH_dom"/>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
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        <property type="entry name" value="Qua1_dom"/>
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        <property type="entry name" value="Sam68-YY"/>
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        <property type="entry name" value="KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Qua1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16568">
        <property type="entry name" value="Sam68-YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="K Homology" evidence="21">
        <location>
            <begin position="141"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="414"/>
            <end position="445"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="8"/>
            <end position="35"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010174"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070445"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00078343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="445" mass="48055" checksum="D0C500195BFBFA40" modified="2020-06-17" version="1">MQRREDLAAPGRLGRAPGPAAPPGRLQSPQAAASPRRPPRGGGGGVRGPQPPPLLPPSATGSAPPAPSVVPTPLIPGAGSAAKAEPENKYLPELMAEKDSLDPSFTHAMQLLQAEIDKIQKGESKKDEEETYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPTRGRGIPVRGRGAVPPPPPVPSVWSGAALLNRGRGVGPPPPPPPRGALVRGAPVRGAIARGAAVARGVPPLPAVRGAPAARARAAGIQRIPLPPPPAPETYEDYGYDDAYAEQSYEGYEGYYSQGQQETEYYDYGHGEAQESYEAYGQDDWNGTRPSLKAPPTRPVKGAYREHPYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IQY5</accession>
    <name>A0A670IQY5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metal transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metal transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ACDP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IQY5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000014871.1">
        <property type="protein sequence ID" value="ENSPMRP00000013914.1"/>
        <property type="gene ID" value="ENSPMRG00000009308.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156317"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000001">
        <property type="entry name" value="Putative metal transporter CNNM3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057492">
        <property type="entry name" value="Ig_CNNM1/2/4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF26">
        <property type="entry name" value="METAL TRANSPORTER CNNM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25562">
        <property type="entry name" value="CNBH_CNNM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25511">
        <property type="entry name" value="Ig_CNNM4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="15">
        <location>
            <begin position="181"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="448"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000013914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="750" mass="83977" checksum="7C5A551B3B2E2114" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IR10</accession>
    <name>A0A670IR10_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lumican</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LUM</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Binds to laminin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028603658.1">
        <property type="nucleotide sequence ID" value="XM_028747825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IR10"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015573.1">
        <property type="protein sequence ID" value="ENSPMRP00000014578.1"/>
        <property type="gene ID" value="ENSPMRG00000009728.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606051"/>
    <dbReference type="KEGG" id="pmua:114606051"/>
    <dbReference type="CTD" id="4060"/>
    <dbReference type="GeneTree" id="ENSGT00940000158177"/>
    <dbReference type="OMA" id="DCPINFP"/>
    <dbReference type="OrthoDB" id="6359842at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005583">
        <property type="term" value="C:fibrillar collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032914">
        <property type="term" value="P:positive regulation of transforming growth factor beta1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000063">
        <property type="entry name" value="Lumican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000073">
        <property type="entry name" value="Lumican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF6">
        <property type="entry name" value="LUMICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0765">Sulfation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025513049" description="Lumican" evidence="14">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="15">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="349" mass="39733" checksum="0914E92404D9D06F" modified="2020-06-17" version="1">MHLNSLPFFLFLISGIFCQYDYDGYYAPQPDYGYAVSMFDHSTAVCAPECTCPISYPSAMYCDNLKLKSLPIIPPGIKYLYLRHNMIEGIEEKAFDNVTDLEWLILDHNHLENSKIKGRVFAKLKSLKKLHINNNNLTEAVGPLPNTLDDVQLTHNKISKINPNTFEGLVNLTVIHLQHNQLSEDTLSGVFKGLNALLYLDLSFNKITKLPLGLPPNLMMLYFDNNQISNIPDQYFQGFKDLQYLRLSHNKLTDSGIPGNAFNISTLVELDLSYNQLKSIPTVNEHLENYYLQVNQINKFPVSSFCKVVGALAYSRVRHLRLDANNLTRSDLPQEMYSCLRMAADITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670ITM9</accession>
    <name>A0A670ITM9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDKN2A interacting protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670ITM9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015851.1">
        <property type="protein sequence ID" value="ENSPMRP00000014839.1"/>
        <property type="gene ID" value="ENSPMRG00000009905.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158376"/>
    <dbReference type="OMA" id="PNMSTTG"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058828">
        <property type="entry name" value="DSRM_CARF/NKRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF11">
        <property type="entry name" value="CDKN2A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26535">
        <property type="entry name" value="DSRM_CARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="347" mass="36503" checksum="7BEEF0B89F8A15CF" modified="2020-06-17" version="1">METDTNPVKNPGKEAANNAEKPLSSTAAQKVAPAASSAVAEKEAPAAASSSVVQKVTPTAPVSTAQKVAPVASSTAPQIVAPTASSTAAQKVAPAAPISAAQKVAPAASSTVTRVEARVANYESTATTRHKSAVASSLPGPESKLNYSLNKPSESKSENTLASEKKGTLEDTAALASKSSSHTSVVPAKVPCKLLTSEDAKERQPFFNRLYKAVAWKLVAVGGFSPNVNHVELLNSSIQSVKATLDVEFVPLKELADLPQNKSSQENVVCELRCKSVYLGTGCGKSKENAKAVASREALKLFLKKKVIVKLCKRKYKGREIEDLVLLDEESKPLNLPPALRNPQEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUC5</accession>
    <name>A0A670IUC5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERI1 exoribonuclease 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Prion interactor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Prion protein-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ERI3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with PRNP.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028589557.1">
        <property type="nucleotide sequence ID" value="XM_028733724.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028589558.1">
        <property type="nucleotide sequence ID" value="XM_028733725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IUC5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016146.1">
        <property type="protein sequence ID" value="ENSPMRP00000015114.1"/>
        <property type="gene ID" value="ENSPMRG00000010087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599110"/>
    <dbReference type="KEGG" id="pmua:114599110"/>
    <dbReference type="CTD" id="79033"/>
    <dbReference type="GeneTree" id="ENSGT00530000063205"/>
    <dbReference type="OMA" id="GSHHLGF"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000029">
        <property type="entry name" value="ERI1 exoribonuclease 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="64"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="256" mass="29085" checksum="CE9ED42E4D467883" modified="2020-06-17" version="1">MVALVRTTAARLHLKLLPRARNTLRSLLRFFPQRYGSTTTGKLASHGFASMAAMSSFPPQRYHYFLVLDFEATCDKPQIHPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVDEWMAKEGLLDPSVKSIFVTCGDWDLKVMLPGQCQYLGLPVADYFKQWINLKKAYSFAMGSWPKNGLLDMNKGLNLQHIGRPHSGIDDCKNIANIMKTLAHRGFIFKQTSKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUD7</accession>
    <name>A0A670IUD7_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IUD7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000015807.1">
        <property type="protein sequence ID" value="ENSPMRP00000014797.1"/>
        <property type="gene ID" value="ENSPMRG00000009875.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235172"/>
    <dbReference type="OMA" id="AKHTSCI"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="591" mass="65203" checksum="2B71AFE4E90C6375" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IUZ5</accession>
    <name>A0A670IUZ5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum resident protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERP29</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028597153.1">
        <property type="nucleotide sequence ID" value="XM_028741320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IUZ5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016020.1">
        <property type="protein sequence ID" value="ENSPMRP00000014997.1"/>
        <property type="gene ID" value="ENSPMRG00000010008.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114602747"/>
    <dbReference type="KEGG" id="pmua:114602747"/>
    <dbReference type="CTD" id="10961"/>
    <dbReference type="GeneTree" id="ENSGT00390000018566"/>
    <dbReference type="OMA" id="FPYGDKH"/>
    <dbReference type="OrthoDB" id="417262at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1150.12:FF:000001">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000133">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016855">
        <property type="entry name" value="ERp29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211">
        <property type="entry name" value="ENDOPLASMIC RETICULUM PROTEIN ERP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ERp29"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="32"/>
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            <begin position="33"/>
            <end position="262"/>
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            <end position="155"/>
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        <location>
            <begin position="156"/>
            <end position="251"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00014173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07749"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000014997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="262" mass="29749" checksum="E7CAB0CDE7F1B761" modified="2020-06-17" version="1">MHRVAMAMGIPRRSALLLLSLLLCLALESSCALHTKGALPLDAITFYKVIPKHKFVLVKFDTQYPYGEKQDEFKKVAESSESSDDLLVAEVGISDYGDKLNMELREKYKLDKDSYPVFYLFQDGDLDNPLPYSGQVKASSLQRWLKSRGIYMGMPGCLKEFDTLASKFVGATKELERQALLEEGRKLLARAKETEQKSSEQYVKVMSKILAQGDQFAASEVSRISKLIEENKMSEGKKEELQKRLNILASFQKKTKEEKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">CHHC U11-48K-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IVC8"/>
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        <property type="protein sequence ID" value="ENSPMRP00000016163.1"/>
        <property type="gene ID" value="ENSPMRG00000010794.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="173" mass="19823" checksum="B239E8FDB89784C9" modified="2020-06-17" version="1">FLPYKGSPEAPVKVLFCRNHQIRACRLPYHLVKCRKNNQKIARELATCPYNARHRVPKQELKLHIATCENKVSPEVLEVTSSRGDPKNRIKEVTAWQCPPPEEDWEADAAECPAPPFVFGTSYSGERSLGTILIYSVRLPMAKKYSKCHCKITTGILQKEQQNTYLFKTQKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IVG5</accession>
    <name>A0A670IVG5_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catenin alpha 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CTNNA3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670IVG5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000016201.1">
        <property type="protein sequence ID" value="ENSPMRP00000015162.1"/>
        <property type="gene ID" value="ENSPMRG00000010117.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234543"/>
    <dbReference type="OMA" id="TWENYIH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005916">
        <property type="term" value="C:fascia adherens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086073">
        <property type="term" value="P:bundle of His cell-Purkinje myocyte adhesion involved in cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098911">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000007">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF21">
        <property type="entry name" value="CATENIN ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000015162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="835" mass="93457" checksum="34BEFF28F8139688" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IW01</accession>
    <name>A0A670IW01_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IW01"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017442.1">
        <property type="protein sequence ID" value="ENSPMRP00000016343.1"/>
        <property type="gene ID" value="ENSPMRG00000010907.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="OMA" id="RINKWHF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="261"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1014" mass="119875" checksum="AA2105BF733A1CFB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IWB6</accession>
    <name>A0A670IWB6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gastrin-releasing peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GRP</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bombesin/neuromedin-B/ranatensin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028605198.1">
        <property type="nucleotide sequence ID" value="XM_028749365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670IWB6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017577.1">
        <property type="protein sequence ID" value="ENSPMRP00000016478.1"/>
        <property type="gene ID" value="ENSPMRG00000010996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606799"/>
    <dbReference type="KEGG" id="pmua:114606799"/>
    <dbReference type="CTD" id="2922"/>
    <dbReference type="GeneTree" id="ENSGT00940000154470"/>
    <dbReference type="OMA" id="KDMMDYL"/>
    <dbReference type="OrthoDB" id="9879745at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000874">
        <property type="entry name" value="Bombesin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16866">
        <property type="entry name" value="GASTRIN-RELEASING PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16866:SF2">
        <property type="entry name" value="GASTRIN-RELEASING PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02044">
        <property type="entry name" value="Bombesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00257">
        <property type="entry name" value="BOMBESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0027">Amidation</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025380816" description="Gastrin-releasing peptide" evidence="10">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="160" mass="18020" checksum="5BA3238C523662CB" modified="2020-06-17" version="1">MARPEFQLLPKPRGLFSLLGLFAFALLLEGRGVRAAPLQGSEGASPMAKVYPRGSHWAVGHFMGKKSSGDFPNLYEERNESPFSLLPDNAKQLGDYLHWEETFKQFLRLLEGNENQSAQVLREESPFPVKSAWEAEDNSSLKDMMDYLLQAMDRKEASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IX34</accession>
    <name>A0A670IX34_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TARS1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670IX34"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017811.1">
        <property type="protein sequence ID" value="ENSPMRP00000016708.1"/>
        <property type="gene ID" value="ENSPMRG00000011116.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154969"/>
    <dbReference type="OMA" id="MMNQRLW"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF36">
        <property type="entry name" value="THREONINE--TRNA LIGASE 1, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="70"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="336"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="712" mass="81757" checksum="274F1C27C13A59E3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IXG9</accession>
    <name>A0A670IXG9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670IXG9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000017778.1">
        <property type="protein sequence ID" value="ENSPMRP00000016675.1"/>
        <property type="gene ID" value="ENSPMRG00000011099.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000242890"/>
    <dbReference type="OMA" id="SIDMACE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000016675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="5784" checksum="8FE2AC6F48FB7A22" modified="2020-06-17" version="1">RSCGGCVLNKLGGVQFEIDLPNEKVNIDSEHSVDTLLNTLKKTGNYVSYLGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670IZL4</accession>
    <name>A0A670IZL4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vitamin K-dependent gamma-carboxylase</fullName>
            <ecNumber evidence="2">4.1.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Gamma-glutamyl carboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidyl-glutamate 4-carboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Vitamin K gamma glutamyl carboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GGCX</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4-carboxy-L-glutamyl-[protein] + 2,3-epoxyphylloquinone + H2O + H(+) = phylloquinol + L-glutamyl-[protein] + CO2 + O2</text>
            <dbReference type="Rhea" id="RHEA:45140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:11094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15759"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28433"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:84990"/>
            <dbReference type="EC" id="4.1.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:45142"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.1.1.90" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A670IZL4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000018767.1">
        <property type="protein sequence ID" value="ENSPMRP00000017628.1"/>
        <property type="gene ID" value="ENSPMRG00000011400.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014909"/>
    <dbReference type="OMA" id="TYLNHYY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008488">
        <property type="term" value="F:gamma-glutamyl carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019842">
        <property type="term" value="F:vitamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046929">
        <property type="term" value="P:negative regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053934">
        <property type="entry name" value="HTTM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007782">
        <property type="entry name" value="VKG_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053935">
        <property type="entry name" value="VKGC_lumenal_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12639">
        <property type="entry name" value="VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12639:SF6">
        <property type="entry name" value="VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05090">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22777">
        <property type="entry name" value="VKGC_lumenal_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM-like" evidence="17">
        <location>
            <begin position="61"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000017628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="758" mass="88024" checksum="C96B43D1A7159C80" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J3P8</accession>
    <name>A0A670J3P8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">CSN12-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PCID2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028583921.1">
        <property type="nucleotide sequence ID" value="XM_028728088.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583922.1">
        <property type="nucleotide sequence ID" value="XM_028728089.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583924.1">
        <property type="nucleotide sequence ID" value="XM_028728091.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028583925.1">
        <property type="nucleotide sequence ID" value="XM_028728092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J3P8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020318.1">
        <property type="protein sequence ID" value="ENSPMRP00000019138.1"/>
        <property type="gene ID" value="ENSPMRG00000012504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114596457"/>
    <dbReference type="KEGG" id="pmua:114596457"/>
    <dbReference type="CTD" id="55795"/>
    <dbReference type="GeneTree" id="ENSGT00390000001101"/>
    <dbReference type="OMA" id="INRMFTL"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905457">
        <property type="term" value="P:negative regulation of lymphoid progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045579">
        <property type="term" value="P:positive regulation of B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000146">
        <property type="entry name" value="PCI domain-containing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="210"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="399" mass="46084" checksum="BFE24CB373FEA2A3" modified="2020-06-17" version="1">MAHISINQYLQQVLESIDSRDGLFCAELVSFKHPHVANPRLQLSSPEEKCQQVLEPPYDEMFAAHLRCTYAVANHDFVEAYKCQTVIVQSFLRAFQAHKEENWALPIMYAVALDLRIFANSADQQLAKKGKGKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDEYSMAQRVTYRYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPMIQLLKKYDLMQFAEVTKAVSEGNLLLLNEALAKHETFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMKVNDVDTDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J4M3</accession>
    <name>A0A670J4M3_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RAF proto-oncogene serine/threonine-protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Raf-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">RAF1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028574754.1">
        <property type="nucleotide sequence ID" value="XM_028718921.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574755.1">
        <property type="nucleotide sequence ID" value="XM_028718922.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574757.1">
        <property type="nucleotide sequence ID" value="XM_028718924.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574758.1">
        <property type="nucleotide sequence ID" value="XM_028718925.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574759.1">
        <property type="nucleotide sequence ID" value="XM_028718926.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574760.1">
        <property type="nucleotide sequence ID" value="XM_028718927.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574761.1">
        <property type="nucleotide sequence ID" value="XM_028718928.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028574762.1">
        <property type="nucleotide sequence ID" value="XM_028718929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J4M3"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020673.1">
        <property type="protein sequence ID" value="ENSPMRP00000019473.1"/>
        <property type="gene ID" value="ENSPMRG00000012698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591641"/>
    <dbReference type="KEGG" id="pmua:114591641"/>
    <dbReference type="CTD" id="5894"/>
    <dbReference type="GeneTree" id="ENSGT00940000156084"/>
    <dbReference type="OMA" id="SAYKRHA"/>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
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            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="555"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000018342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1010" mass="116604" checksum="291E787BDE2A5AD3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J665</accession>
    <name>A0A670J665_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DUSP3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A670J665"/>
    <dbReference type="Ensembl" id="ENSPMRT00000020259.1">
        <property type="protein sequence ID" value="ENSPMRP00000019079.1"/>
        <property type="gene ID" value="ENSPMRG00000012469.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163612"/>
    <dbReference type="OMA" id="MMKRGMN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033549">
        <property type="term" value="F:MAP kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050922">
        <property type="term" value="P:negative regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050868">
        <property type="term" value="P:negative regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050860">
        <property type="term" value="P:negative regulation of T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120183">
        <property type="term" value="P:positive regulation of focal adhesion disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045931">
        <property type="term" value="P:positive regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682">
        <property type="entry name" value="AGAP008228-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR620405-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000019079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="118" mass="13568" checksum="94AE00143C43E056" modified="2020-06-17" version="1">MHVNTNAEFYEGTGITYHGIKANDTQEFNLSRYFEEAADFIEKALAQKDGRVFVHCREGYSRSPTLVIAYLMLRQNMDVKSAVSIVRQKREIGPNDGFLRQLCQLNDRLVKEGKLKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J8L6</accession>
    <name>A0A670J8L6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A670J8L6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000021257.1">
        <property type="protein sequence ID" value="ENSPMRP00000020019.1"/>
        <property type="gene ID" value="ENSPMRG00000013038.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159017"/>
    <dbReference type="OMA" id="RGNDGHR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16695">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000363">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="236" mass="23606" checksum="D96ABAA81C972629" modified="2020-06-17" version="1">MGAKQSGPAAANGRTRAYSGGDLPSSSGGGANGRPAGGAARYTHLAPGGQHHAGPGGSASGASAAAPRSRSLGGPGASGARAAHSAFNIPNSSGLYGSQDSVSSTPEEGGRERAAAGGGGGGGAGGGHGSGRPRLVIGSLPAHLSPHLFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670J9T5</accession>
    <name>A0A670J9T5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ACOX2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028575424.1">
        <property type="nucleotide sequence ID" value="XM_028719591.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575425.1">
        <property type="nucleotide sequence ID" value="XM_028719592.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575426.1">
        <property type="nucleotide sequence ID" value="XM_028719593.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028575427.1">
        <property type="nucleotide sequence ID" value="XM_028719594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670J9T5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000022248.1">
        <property type="protein sequence ID" value="ENSPMRP00000020950.1"/>
        <property type="gene ID" value="ENSPMRG00000013621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114591888"/>
    <dbReference type="KEGG" id="pmua:114591888"/>
    <dbReference type="CTD" id="8309"/>
    <dbReference type="GeneTree" id="ENSGT00940000160985"/>
    <dbReference type="OMA" id="NHGVHCF"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033791">
        <property type="term" value="F:3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006699">
        <property type="term" value="P:bile acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000038">
        <property type="term" value="P:very long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000006">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF344">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="15">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="16">
        <location>
            <begin position="290"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="489"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000020950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="675" mass="75783" checksum="B3D786A3E496F893" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JCK5</accession>
    <name>A0A670JCK5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endothelin-converting enzyme 1</fullName>
            <ecNumber evidence="6">3.4.24.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ECE1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Converts big endothelin-1 to endothelin-1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.</text>
            <dbReference type="EC" id="3.4.24.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer; disulfide-linked. Interacts with PPP1R16B. Interacts with TSPAN8; this interaction recruits the endothelin converting enzyme ECE1 to tetraspanin-enriched microdomains and positively modulates its enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.71" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A670JCK5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023464.1">
        <property type="protein sequence ID" value="ENSPMRP00000022091.1"/>
        <property type="gene ID" value="ENSPMRG00000013459.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156050"/>
    <dbReference type="OMA" id="DQRFFMN"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033093">
        <property type="term" value="C:Weibel-Palade body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060385">
        <property type="term" value="P:axonogenesis involved in innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010815">
        <property type="term" value="P:bradykinin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010816">
        <property type="term" value="P:calcitonin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043583">
        <property type="term" value="P:ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035050">
        <property type="term" value="P:embryonic heart tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034959">
        <property type="term" value="P:endothelin maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060037">
        <property type="term" value="P:pharyngeal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001921">
        <property type="term" value="P:positive regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902287">
        <property type="term" value="P:semaphorin-plexin signaling pathway involved in axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010814">
        <property type="term" value="P:substance P catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097492">
        <property type="term" value="P:sympathetic neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000076">
        <property type="entry name" value="membrane metallo-endopeptidase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF130">
        <property type="entry name" value="ENDOTHELIN-CONVERTING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="24">
        <location>
            <begin position="101"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="23">
        <location>
            <begin position="547"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="756"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="802" mass="91500" checksum="076208EB3E234DA6" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JD26</accession>
    <name>A0A670JD26_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Envelope glycoprotein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JD26"/>
    <dbReference type="Ensembl" id="ENSPMRT00000023463.1">
        <property type="protein sequence ID" value="ENSPMRP00000022090.1"/>
        <property type="gene ID" value="ENSPMRG00000014372.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165291"/>
    <dbReference type="OMA" id="KHICDTE"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TLV_coat"/>
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    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025399684" description="Envelope glycoprotein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022090.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54127" checksum="7C31B0678C9F73F5" modified="2020-06-17" version="1">MHMLDINMILLLILIPWEGEGSLNLTKFAKYGFSHDHNMWVGLAEMVANVANRTNCLVCSLGPDDSEGGMPLLPIPLDAIGMVSEMPHQTEIQNFPGWNSTKPLRVIPVQGEFCVHKSSDAADSTMIGSSHCHYTWDYIKNSHTWAHGTTYRTRNTLPCAPPFIHAWKVVWNITVTEKGNLTYCTVNSLPLLIFRLLYSTYQKPQTRWLWWICGEWAYKKLPSKWSGTCFLGWVLPPMWIMPTSSAKRTRRNADISRIAGGSTQSWSGTDDWPPERIIAYYDPASWNPGELIQGARDPIYNLNRIIRLQAVVELVTNATAQSLRLIAQQLDESRAAILQLKMGMDYVLARQGGLCGVLNLTGNACCFNISDNGEAIRVLATKMENIAHVPVQTWEGWDMGWLTNWLPNVTGLKGILLSCLFFLTVVVMVLCMVPCIISCFRSTISKMVSNETLPHIMALYRALPQEYDEGQAIKDTWDEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JE53</accession>
    <name>A0A670JE53_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="9">1.3.1.124</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2,4-dienoyl-CoA reductase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DECR2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + NADPH + H(+) = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77559"/>
            <dbReference type="ChEBI" id="CHEBI:84791"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
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            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer, dimer and oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A670JE53"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024243.1">
        <property type="protein sequence ID" value="ENSPMRP00000022818.1"/>
        <property type="gene ID" value="ENSPMRG00000014816.1"/>
    </dbReference>
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    <dbReference type="OMA" id="MQAHVCA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019166">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000477">
        <property type="entry name" value="Peroxisomal 2,4-dienoyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025787"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000022818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="298" mass="32052" checksum="EAE087014819D7B3" modified="2020-06-17" version="1">MSQLGFACQPPPDVDTDDCLPEYSYLFSPDILKGKVAFITGGSSGIGFRTAEILMRHGCHTIIASRNLQRLTEAAKKLSVATGQRCLPLTLDVRQPQMIMAAVDEALKEFERIDILVNNAAGNFLCPASALSFNAYKTVIEIDTLGTFNVSKVLYEKCLRDHGGVIVNISATLSYRGQALQVHAGTAKAAIDSMTKHLAVEWGPNGIRVNSLAPGPISGTEGHRRLVQPHPEAQNLFRNIPLQRVGNKTEIAHSVLYLASPLASYVSGTTLVVDGGAWMTSENNFPALLGIASHSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JG65</accession>
    <name>A0A670JG65_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-set and immunoglobulin domain-containing protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114587142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028566937.1">
        <property type="nucleotide sequence ID" value="XM_028711104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JG65"/>
    <dbReference type="Ensembl" id="ENSPMRT00000024479.1">
        <property type="protein sequence ID" value="ENSPMRP00000023045.1"/>
        <property type="gene ID" value="ENSPMRG00000014961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587142"/>
    <dbReference type="GeneTree" id="ENSGT00940000161712"/>
    <dbReference type="OMA" id="PSPIYVK"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052871">
        <property type="entry name" value="V-set/Ig_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45166">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45166:SF1">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="193"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="469" mass="50521" checksum="DBF9FB0422D917A1" modified="2020-06-17" version="1">MSLATNCSQFRTLRLLYIPLFFCPPALLPAVKINAKGREVVYLAEGESAKLGCPYELEPQDHGSNDLDIEWTQMNSDPTNLDNVILSYNNHQVIHPGYHFLQSRGGSGAHDSRQFGNSGLQQNMVMGVSGHDCCSGLQQRVTFAIQDPSQYDASINLQNVQISDSATYECKVKKTTVATRKVTVMVLARPSNPQCSVVGKVALGQKVTLSCSSNSGTSPLMYQWAKVTDHPFANWLSATTTKGPNPGDLIIQNLSNDHAGVYQCSVANKVGSARCVVEISFSKESNRVSIVVGVVLGSLLFLTLLVCLIVGLICCCRKRRYKEEANQIRVDTAPPRAKGGSRNSSIRSVLDFVPHNISFMQRRKYGTPKEQEGSEMISPAQEAQPMDCSGVKSEPHRGGCSTTVTTKARVHYAPSVPSSPQATSSPSAAGPENGGSCSITSEKGRRGHPGQYGGVAVMVPAKSRDGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJ33</accession>
    <name>A0A670JJ33_PODMU</name>
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        <recommendedName>
            <fullName evidence="9">Period circadian protein homolog 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Circadian clock protein PERIOD 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PER2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JJ33"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026345.1">
        <property type="protein sequence ID" value="ENSPMRP00000024828.1"/>
        <property type="gene ID" value="ENSPMRG00000016046.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156342"/>
    <dbReference type="OMA" id="ENCSMGR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Period circadian protein homolog 3"/>
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    </dbReference>
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        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
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    </dbReference>
    <dbReference type="InterPro" id="IPR057310">
        <property type="entry name" value="PER1-3_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048814">
        <property type="entry name" value="Per1-3_PAS-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022728">
        <property type="entry name" value="Period_circadian-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050760">
        <property type="entry name" value="Period_circadian_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269:SF9">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23170">
        <property type="entry name" value="bHLH_PER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21353">
        <property type="entry name" value="Per3-like_PAS-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12114">
        <property type="entry name" value="Period_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="321"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="765"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="943"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1020"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1109"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
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        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="964"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1049"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="1265" mass="139475" checksum="A0AA0A536772545A" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJN6</accession>
    <name>A0A670JJN6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JJN6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026643.1">
        <property type="protein sequence ID" value="ENSPMRP00000025108.1"/>
        <property type="gene ID" value="ENSPMRG00000016234.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000204784"/>
    <dbReference type="OMA" id="IVDINEW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="219"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="357" mass="40243" checksum="477DDB62BFD2EF47" modified="2020-06-17" version="1">MMEDRCGHPQRHVLKMEGEGTAAVACGSCAMFAILPKVAGSFTCSNCMLIALLKDKVQQLEERVATLQRIRELELFLESTEHTVSTKEETGDSPEKEASSPTQEPDIWRNVTQRSRRPRVRSDCLEIHNRFEVLSPNMEDEEQTPFEDLSLITVDQVYEDEQQSQSSGNVQATLEQTAHGRTPTRPKRRRVVVIGDSLLRGTEAVICGPDKMSREVCCLPGAKIQDVTERLQGIIKPTDKYPFLLVHVGTNDTASNSLQKIKRDYEALGRKLKQLNAQIVISSVLPVERRGPGREGKIVEVNSWLRKWCKQERFGFLDHGLQFLEDGLLASDGLHLTTLGRNVFAKNLRNLIRRALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JJX6</accession>
    <name>A0A670JJX6_PODMU</name>
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        <submittedName>
            <fullName evidence="5">FAU ubiquitin like and ribosomal protein S30 fusion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FAU</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JJX6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025293.1">
        <property type="protein sequence ID" value="ENSPMRP00000023834.1"/>
        <property type="gene ID" value="ENSPMRG00000015437.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007479"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002227">
        <property type="term" value="P:innate immune response in mucosa"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF37">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000023834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="191" mass="20356" checksum="7D682648300C5329" modified="2020-06-17" version="1">MPLQKFSRAFLGEGWAHTLPHLCCLFLEGVGSSHTRATEELAVDGSFQLNSVFLVPGLCATLPAVAIRAVGCFGDSSLPSPPQAHIESLEGIVPEDQVILLGGTPLEDDAVIGQCGISDLTTLEVAARMLGGKVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNIVPGFGKKKGPNANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JK86</accession>
    <name>A0A670JK86_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PRKR interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRKRIP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JK86"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026297.1">
        <property type="protein sequence ID" value="ENSPMRP00000024781.1"/>
        <property type="gene ID" value="ENSPMRG00000016021.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005003"/>
    <dbReference type="OMA" id="MRINKLM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23834" checksum="A2A8F3413274FB24" modified="2020-06-17" version="1">MTVALRDVIGRGRGLLRRRRRRGNQKGGGRMAAGPTRPSRPRKEPQPLVIPRSAADEQRLKLERLMRNPDKTVPIPEKLNEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDFMDAMAEKQKLDEEYQKKLEKNKIVAEEQTAKRRRKRQKLKEKKMLAKKSKLEQKSEHAGNVKTHLLEFSSPGNSFCSQVPTEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JKN4</accession>
    <name>A0A670JKN4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP synthase F1 subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATP5IF1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JKN4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025548.1">
        <property type="protein sequence ID" value="ENSPMRP00000024084.1"/>
        <property type="gene ID" value="ENSPMRG00000015582.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006264"/>
    <dbReference type="OMA" id="FCEAPAR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043532">
        <property type="term" value="F:angiostatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140260">
        <property type="term" value="F:mitochondrial proton-transporting ATP synthase complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051882">
        <property type="term" value="P:mitochondrial depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001937">
        <property type="term" value="P:negative regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901030">
        <property type="term" value="P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903052">
        <property type="term" value="P:positive regulation of proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905091">
        <property type="term" value="P:positive regulation of type 2 mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072593">
        <property type="term" value="P:reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903578">
        <property type="term" value="P:regulation of ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903214">
        <property type="term" value="P:regulation of protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000003">
        <property type="entry name" value="ATPase inhibitor B, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="107" mass="12269" checksum="495F6E7464ADD6FC" modified="2020-06-17" version="1">MAAVGSVLRCGFRGALALPQQQRAWSSGADQVLGWGEVGSGTVREAGGAFGKREAAMEERYFRYREQLAELKKHHEDEIQHQKKEIERLQKEIERHKYKLKKLTDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JL38</accession>
    <name>A0A670JL38_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SLC30A5</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Functions as a zinc transporter.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">COPII-coated vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Secretory vesicle membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Golgi apparatus</location>
            <location evidence="1 19">trans-Golgi network membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028604084.1">
        <property type="nucleotide sequence ID" value="XM_028748251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JL38"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026629.1">
        <property type="protein sequence ID" value="ENSPMRP00000025096.1"/>
        <property type="gene ID" value="ENSPMRG00000016222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606251"/>
    <dbReference type="KEGG" id="pmua:114606251"/>
    <dbReference type="CTD" id="64924"/>
    <dbReference type="GeneTree" id="ENSGT00940000155754"/>
    <dbReference type="OMA" id="NHLFYHF"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990674">
        <property type="term" value="C:Golgi cis cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF1">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 19" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="21">
        <location>
            <begin position="417"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="548"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000025096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="771" mass="84910" checksum="67C56BB000EFABF4" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JMP9</accession>
    <name>A0A670JMP9_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain containing 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC42</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028573017.1">
        <property type="nucleotide sequence ID" value="XM_028717184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JMP9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000025731.1">
        <property type="protein sequence ID" value="ENSPMRP00000024262.1"/>
        <property type="gene ID" value="ENSPMRG00000015684.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114590751"/>
    <dbReference type="KEGG" id="pmua:114590751"/>
    <dbReference type="CTD" id="146849"/>
    <dbReference type="GeneTree" id="ENSGT00940000153110"/>
    <dbReference type="OMA" id="CADKKRV"/>
    <dbReference type="OrthoDB" id="2134857at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002177">
        <property type="term" value="C:manchette"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097228">
        <property type="term" value="C:sperm principal piece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001675">
        <property type="term" value="P:acrosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cilium assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF8">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42"/>
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    </dbReference>
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        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13863">
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    </dbReference>
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        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="103"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="319" mass="37923" checksum="3BF04FDF73FF4402" modified="2020-06-17" version="1">MTTMDEEDLSEYFRIQYGQKLLKLLMKFPVSEEESPSPSIRLLEKKKEAKLVHQAMEAQKEAFKTRMEALNNRWEELGSKEIQLKAYIRKFEQFIQENDQKRIRALKKANKERELKKQRVKELAKAKIEMAALKQQHQKLYNKLQQYSIFNKYLEKVVEVSEFEEIREVIGRYKTLVGMHRDLVQSAQEGMEMIEQAKVRLARYKEEKDDEMLQHNNELARLQLRFDHARSDVIVWESRWAHIQNTAAKKTLMLGTIKMATLNLFQSVAKQMKEALMVPVEDTHKQLDMIQQFIQDLSDIWSEVKKKEQNRSLTGMNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNH7</accession>
    <name>A0A670JNH7_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein 40 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">WD repeat-containing protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SNRNP40</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028598611.1">
        <property type="nucleotide sequence ID" value="XM_028742778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JNH7"/>
    <dbReference type="Ensembl" id="ENSPMRT00000026028.1">
        <property type="protein sequence ID" value="ENSPMRP00000024532.1"/>
        <property type="gene ID" value="ENSPMRG00000015842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603617"/>
    <dbReference type="KEGG" id="pmua:114603617"/>
    <dbReference type="CTD" id="9410"/>
    <dbReference type="GeneTree" id="ENSGT00940000155058"/>
    <dbReference type="OMA" id="IWDIRPY"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000375">
        <property type="term" value="P:RNA splicing, via transesterification reactions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000229">
        <property type="entry name" value="Small nuclear ribonucleoprotein U5 subunit 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000024532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="359" mass="39227" checksum="48710CFC74B0DA69" modified="2020-06-17" version="1">MIDPQKRKAPGPDMALVATASGAKKPRHELILGPGPGAGQPPPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGATLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAVQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRIWDVRPFAPKERCVKILQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPEEPIILSASSDKRLYMGEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JNQ8</accession>
    <name>A0A670JNQ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vasculin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GC-rich promoter-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPBP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a GC-rich promoter-specific transactivating transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vasculin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028603993.1">
        <property type="nucleotide sequence ID" value="XM_028748160.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028603994.1">
        <property type="nucleotide sequence ID" value="XM_028748161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JNQ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028306.1">
        <property type="protein sequence ID" value="ENSPMRP00000026683.1"/>
        <property type="gene ID" value="ENSPMRG00000017248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114606210"/>
    <dbReference type="KEGG" id="pmua:114606210"/>
    <dbReference type="CTD" id="65056"/>
    <dbReference type="GeneTree" id="ENSGT00420000029753"/>
    <dbReference type="OMA" id="WREDSEN"/>
    <dbReference type="OrthoDB" id="8741226at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028128">
        <property type="entry name" value="Vasculin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14339">
        <property type="entry name" value="VASCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14339:SF11">
        <property type="entry name" value="VASCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15337">
        <property type="entry name" value="Vasculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000026683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="466" mass="52604" checksum="0297DFCD2E9F1F1A" modified="2020-06-17" version="1">MAQHDFAPAWLNFPTPPSSSKSSLNFEKHSDSFSWTENRYEVNRRRHNSSDGFDPSSGRSNGGHLGRKERNGWRSQGRNGTENTHHRVGYHSGGSRARASSFQSGKSQGLHEKNAPESETLKKEDKEEPKQFEAEDFPSLNPEYEREPNQNKSLAAGVWEYPLNPKSRSPRMLVIKKGSTKDLQISGFPVAGNIHSQSVKNGTGTSVYKGLVPKPVIPPAKTTQWKSQTKDNKLGPPFPHDSPYGIGNFSAFKSTAKAVGSQNSVKECNRSNSSSPVDKLGQPRLTKLTRMRTDKKSEFLKTLKRDRVEEEHDGQEKDDDDEFNLHNSNNGHEERDINRNFENEIPQENRNAIMMSQQIIRSSTFPQTDVLSSSLEAEHRLLKEMGWQEDSENDETCAPLTEDEMREFQVISEQLQKNGLRKNGILKNGLICDFKFSPWKNSTFKPTIENDDTETSSSDTSDDDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JP79</accession>
    <name>A0A670JP79_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="7">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">COQ5</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Methyltransferase required for the conversion of 2-decaprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="function">
        <text evidence="7">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028566965.1">
        <property type="nucleotide sequence ID" value="XM_028711132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JP79"/>
    <dbReference type="Ensembl" id="ENSPMRT00000027824.1">
        <property type="protein sequence ID" value="ENSPMRP00000026221.1"/>
        <property type="gene ID" value="ENSPMRG00000016967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114587160"/>
    <dbReference type="KEGG" id="pmua:114587160"/>
    <dbReference type="CTD" id="84274"/>
    <dbReference type="GeneTree" id="ENSGT00390000001654"/>
    <dbReference type="OMA" id="MNDVMSM"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110142">
        <property type="term" value="C:ubiquinone biosynthesis complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000064">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
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</entry>
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                <person name="Brejcha J."/>
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</entry>
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                <consortium name="Ensembl"/>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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</entry>
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                <person name="Salvi D."/>
                <person name="Soler L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028563923.1">
        <property type="nucleotide sequence ID" value="XM_028708090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JU80"/>
    <dbReference type="Ensembl" id="ENSPMRT00000028647.1">
        <property type="protein sequence ID" value="ENSPMRP00000027004.1"/>
        <property type="gene ID" value="ENSPMRG00000017429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114585435"/>
    <dbReference type="KEGG" id="pmua:114585435"/>
    <dbReference type="CTD" id="11095"/>
    <dbReference type="GeneTree" id="ENSGT00940000159642"/>
    <dbReference type="OMA" id="FFIPKDI"/>
    <dbReference type="OrthoDB" id="412680at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
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        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
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        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000048">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 8"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013277">
        <property type="entry name" value="Pept_M12B_ADAM-TS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF41">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01861">
        <property type="entry name" value="ADAMTS8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="15 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 19 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="11 19 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025362528" description="A disintegrin and metalloproteinase with thrombospondin motifs 1" evidence="22">
        <location>
            <begin position="38"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="23">
        <location>
            <begin position="198"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" evidence="18 21">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="273"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="302"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="319"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="450"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000027004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="921" mass="101256" checksum="AA287AFF89BD42D3" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JUZ8</accession>
    <name>A0A670JUZ8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670JUZ8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030821.1">
        <property type="protein sequence ID" value="ENSPMRP00000029053.1"/>
        <property type="gene ID" value="ENSPMRG00000018782.1"/>
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        <property type="component" value="Chromosome 17"/>
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        <property type="entry name" value="RT_nLTR_like"/>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="321"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000029053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="995" mass="117694" checksum="B9A640FC0A731F30" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JVR9</accession>
    <name>A0A670JVR9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670JVR9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030292.1">
        <property type="protein sequence ID" value="ENSPMRP00000028556.1"/>
        <property type="gene ID" value="ENSPMRG00000018446.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166459"/>
    <dbReference type="OMA" id="WDTQPQP"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CAP_dom"/>
    </dbReference>
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        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034121">
        <property type="entry name" value="SCP_GLIPR-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
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        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0872">Ion channel impairing toxin</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="8">
        <location>
            <begin position="38"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="182" mass="21092" checksum="05594304417D6AF8" modified="2020-06-17" version="1">QISRLEIHFFFGVLLFLNLSISCYFYEPNTLPDIGNAEFIEECVRVHNKFRSNVNPPATNMKRMSWDHKLAETAKGWAKRCLFQHNYDIKIPGKVHPNFTTAGENIWTGSFQIFNVTSALTDWYNEVVHYDYDTRYCSDVCGHYTQMVWATTYKVGCAVLFCRQVTGFTSNAAHFICNYGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JWV1</accession>
    <name>A0A670JWV1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 16">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MPI</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 16"/>
    <dbReference type="RefSeq" id="XP_028599490.1">
        <property type="nucleotide sequence ID" value="XM_028743657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JWV1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000030083.1">
        <property type="protein sequence ID" value="ENSPMRP00000028360.1"/>
        <property type="gene ID" value="ENSPMRG00000018299.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603998"/>
    <dbReference type="KEGG" id="pmua:114603998"/>
    <dbReference type="CTD" id="4351"/>
    <dbReference type="GeneTree" id="ENSGT00390000016075"/>
    <dbReference type="OMA" id="DIGLFCG"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061729">
        <property type="term" value="P:GDP-D-mannose biosynthetic process from fructose-6-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061611">
        <property type="term" value="P:mannose to fructose-6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.441.10:FF:000001">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000044">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000060">
        <property type="entry name" value="Putative mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="20">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="21">
        <location>
            <begin position="170"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="19">
        <location>
            <begin position="337"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="423" mass="46343" checksum="3495AD5D60A9240C" modified="2020-06-17" version="1">MAELRVFPLACAVQNYSWGKLGQDSEVASLLASSDPMIHIEAGKPYAELWMGTHPKGDAMILDNRIPQKTLRQWIADNPDSLGTKVKEAFQGQLPFLFKVLSVNSALSIQAHPTKELAEKLHAQYPEHYPDANHKPEMAIALTPFEGMCGFRPVEEIVSFLQNVPEFRALIGNVAAEQLERCVGEDPRGVSAALRICFTRMMKSEKKVFVDQLNMLVKRISQEADAGKDTSASCGELLLRLHSQYPGDIGCFAIYFLNLMKLQPGECMFLGANEPHAYIYGDCIECMACSDNTVRAGLTPKFIDVLTLCEMLNYTPAPGSSKLLSPVQSRLDPCVYLYDPPVPDFSVMRIEIPSSIKLYLISAIDSASILLVVQGTAVGTSTAAASEMAVRRGSVLFISANESVSLHLSAPDGMLLFRACCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JXQ2</accession>
    <name>A0A670JXQ2_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-X-C chemokine receptor type 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">High affinity interleukin-8 receptor B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114603388</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with IL8. Interacts with GNAI2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028598192.1">
        <property type="nucleotide sequence ID" value="XM_028742359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670JXQ2"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031899.1">
        <property type="protein sequence ID" value="ENSPMRP00000030083.1"/>
        <property type="gene ID" value="ENSPMRG00000019455.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114603388"/>
    <dbReference type="KEGG" id="pmua:114603388"/>
    <dbReference type="GeneTree" id="ENSGT01050000244848"/>
    <dbReference type="OMA" id="CMGIWVV"/>
    <dbReference type="OrthoDB" id="9946013at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016494">
        <property type="term" value="F:C-X-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15178">
        <property type="entry name" value="7tmA_CXCR1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000174">
        <property type="entry name" value="Chemokine_CXCR_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF689">
        <property type="entry name" value="C-X-C CHEMOKINE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00427">
        <property type="entry name" value="INTRLEUKIN8R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="68"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="359" mass="40381" checksum="AF97708169F2E0A1" modified="2020-06-17" version="1">MAKTVLFSDLDLSDLYPDANYSDYDYYGTFNPNSVAAKAPCGIDVMPPVFKYLVAFIYGLTCLLSLVGNSLVVLVIAYSKGNRSVTDVYLLNLAIADLLFALTLPFWAVDRAHEWIFGTPMCKILSLLKEVNFYSGILLLAGISMDRYLAIVHATRAVTQKRSWVRFVCVGIWLLSFLLSLPVIIFHEAFLPTEEMKWVCHEYIGWNQISGIRAKLRILPQTFGFILPLIVMLFCYGVMVHRLYQTKNSQKKKAMKVILAVVLVFLVCWLPYNISLLLDTLMRSGAIGETCDLRNSIDTALSGTEILGFAHSCVNPIIYTSIGQKFRNNFLKILVTRGIISKEALTRFRRGSSFSSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670JZR8</accession>
    <name>A0A670JZR8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
            <ecNumber evidence="3">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SULT1B1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A670JZR8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000029938.1">
        <property type="protein sequence ID" value="ENSPMRP00000028217.1"/>
        <property type="gene ID" value="ENSPMRG00000018133.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161848"/>
    <dbReference type="OMA" id="IIYLCRE"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004062">
        <property type="term" value="F:aryl sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050427">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006068">
        <property type="term" value="P:ethanol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009812">
        <property type="term" value="P:flavonoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051923">
        <property type="term" value="P:sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042403">
        <property type="term" value="P:thyroid hormone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="51"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="306" mass="35810" checksum="E41B3BB1E96C4518" modified="2025-10-08" version="2">MLGWQEQGPSNEKMGSPDSYLRKDWQMVRGIPMVCAFSFDWDRIDRFQSRPDDIVISTYPKSGTTWMSEIVDLIRNDGDPDKSKRAIFNKVPMLEFAAPGKMPPEQLTQMPSPRLVKTHLPIDLLPKSFWENGCKMIYVARNAKDVAVSFYHFDLMNKLHPDPGPWDNYLEEFMAGRVAFGSWYDHVKSWWDKRNDHPILYLFYEDMKEDPKREIKKVVHFLGKNLEDSVVDKIAYNTSFELMKDNPATNYRMAPAAVMDHSISPFMRKGIAGDWKNHFTVAQNEVFDEDYKRKMADTTLRFRTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0C5</accession>
    <name>A0A670K0C5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRISC and BRCA1-A complex member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mediator of RAP80 interactions and targeting subunit of 40 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">New component of the BRCA1-A complex</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BABAM1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BABAM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K0C5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032109.1">
        <property type="protein sequence ID" value="ENSPMRP00000030281.1"/>
        <property type="gene ID" value="ENSPMRG00000019582.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016934"/>
    <dbReference type="OMA" id="SCTTAWP"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21502">
        <property type="entry name" value="vWA_BABAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026126">
        <property type="entry name" value="BABAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660:SF1">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="359" mass="40031" checksum="38D10745DD311F49" modified="2020-06-17" version="1">MELSPPKPCCFLPFPGRPSGTANLDSPLDRGALMDTSEPSSATEEEEEKVTAEQRPRTRSNPEGAEDRTLSAQASVGSRSEGEGEAASTGDSPQSATATNGKGWPPTVPPTEFQVRTPRVNCPEKVIICLDLSEEMSHSKLESFNGSKTNALNISQKMIEMFVRTKHKIDKSHEFALVVVNNDVTWLSGFTSDPREVCSCLYDLETVVCKSFNLEGLFSLIQQKTELPVTENVQSIPPPYVVRTILVYSRPACHPPVTITEQMKKMLQCPYYYFDVLYIHNGFEDKEEETSWKETFAFFSNLDSKGTNYKYEVSLTGPAVELHNCMAKLLAHPLQRPFQTHASYSMLEEEEAVEIEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0J8</accession>
    <name>A0A670K0J8_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K0J8"/>
    <dbReference type="Ensembl" id="ENSPMRT00000031464.1">
        <property type="protein sequence ID" value="ENSPMRP00000029665.1"/>
        <property type="gene ID" value="ENSPMRG00000019187.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004581"/>
    <dbReference type="OMA" id="GAYFRCR"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
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        </location>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="264" mass="28797" checksum="0DDE96A14F2560E4" modified="2020-06-17" version="1">MIVKLVKCINLKSNNNNNNNNNIMDGSGPIQKVVLLCMSLCLANDSPFSSPSCPTVSVVDFCGQTLHGDGMVLTSHRDSRRYYFVVASTDCQLTMQAATPKDKVQFQFRFFLVYSMVRSPSSTLASNDHPTLALPKSRSERETPDPCTAGSYVQFYDGQNHTAKPLGMPLCGKNIPRPVTSTGNFLTLRLVTRGQQPRVDFVGDFTSVRTGLNASACSMESYFPCHNGKCIPPSLVCDGSSVDNCGDGTDQAAQSPAWCKGWWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K0W0</accession>
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        </recommendedName>
    </protein>
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        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
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            <taxon>Lepidosauria</taxon>
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            <taxon>Bifurcata</taxon>
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            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K0W0"/>
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        <property type="protein sequence ID" value="ENSPMRP00000028612.1"/>
        <property type="gene ID" value="ENSPMRG00000018493.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 15"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
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        <location>
            <begin position="412"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="544"/>
            <end position="659"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000028612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="850" mass="93004" checksum="71E2DFD6D6A974D7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K1D8</accession>
    <name>A0A670K1D8_PODMU</name>
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        <submittedName>
            <fullName evidence="1">Proteasome assembly chaperone 3</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="primary">PSMG3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
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                <person name="Andersson L."/>
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            <dbReference type="PubMed" id="30819892"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="122" mass="12976" checksum="5A2DE02F64135453" modified="2020-06-17" version="1">MAARSLVDSKQAEEVVQGIPTEVVCTAFANTILVVVTQYGKMGTLVSVEPNVVADGISSPLLTTKVLLGKDEPLVHICAKHLATSVSQEAGNKPVLLALALKDKSVEGIRILKEVIGRCRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K4G5</accession>
    <name>A0A670K4G5_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit mu-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AP1M1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
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        <lineage>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
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                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
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                <person name="Salvi D."/>
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                <person name="While G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Clathrin-coated vesicle membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K4G5"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034374.1">
        <property type="protein sequence ID" value="ENSPMRP00000032418.1"/>
        <property type="gene ID" value="ENSPMRG00000021002.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157924"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035646">
        <property type="term" value="P:endosome to melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000002">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="168"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="433" mass="49430" checksum="B33482F95B86928A" modified="2020-06-17" version="1">MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGTLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSAIVWSVKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGGRWRGACSSPSLHLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K580</accession>
    <name>A0A670K580_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K580"/>
    <dbReference type="Ensembl" id="ENSPMRT00000032675.1">
        <property type="protein sequence ID" value="ENSPMRP00000030809.1"/>
        <property type="gene ID" value="ENSPMRG00000019962.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160673"/>
    <dbReference type="OMA" id="STHQMTF"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000061">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF177">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000030809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="327" mass="35633" checksum="DA7E8E229F08E67E" modified="2020-06-17" version="1">MSLQSNSHHPFSFSLLQDWTCNSPPEDATACHPSLTFAAVPTAPHLSASSSGAYESVGMFQLWSNEVPSGSHTTMAFGLPKVPYHGQGPASSGAAHELPLTPPAEPTYSFELSPVKMLAPTMPHSYAFPEAQDFSSFLQGPRPLGPAPPPGTTSTDDGPWWSLQQPGNFSLGRPLVLSPQPPLAALLQGTPKGLLGTTRRCRRCKCPNCQAVNGASEEPGRKKQHICHLPGCGKVYGKTSHLKAHLRWHAGERPFICSWLYCGKSFTRSDELQRHLRTHTGEKRFGCQLCPKRFMRSDHLAKHVKTHQGKRMRGMAMVAAAVGIKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K6T6</accession>
    <name>A0A670K6T6_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">WDR18</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Dynein axonemal particle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670K6T6"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033930.1">
        <property type="protein sequence ID" value="ENSPMRP00000031995.1"/>
        <property type="gene ID" value="ENSPMRG00000020734.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000289"/>
    <dbReference type="OMA" id="XGSEPSY"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000420">
        <property type="entry name" value="WD repeat-containing protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000702">
        <property type="entry name" value="WD repeat-containing protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026987">
        <property type="entry name" value="WDR18_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14077">
        <property type="entry name" value="WDR18_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 18 C-terminal" evidence="15">
        <location>
            <begin position="443"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="492" mass="52896" checksum="6ACEA872FADC0D98" modified="2020-06-17" version="1">MAAAGGPVEVALVSAAEAASSSGGGCSVWEVGSGASVAGYRGFSCAARGMALLGGEHLLGAQLGKACVGAWELQRKDQLQQKIICPGLVSCLAAAPNGLYILAGIAESIYLWEVSSGNLLAILNRHYQDLSCVAFTDDSSHFLSGAKDSLVIVWNLYSVLQAENAQSPEPRHVWSRHSLPITDLCCGMGGPMARAATASLDQTAKLWEISSGDLLLSVVFDVGILSVTLDLTEYHMFCGGMDGSIFQVDLCAWPVQRERGFQTEREAAKIFKGHRNQVTCLSVSTDGSLLLSGSHDETVRLWDIQSKQCLRTVNYKGPVTNAFITLAPANMLNPESKPRVPLPKFSRHLYTMENAGSPASEGMMLCLGMHQKTDGAVFFDGLAPCKGRPRARSSPLAPHGLSFSSSEFPSAAAGRVSGRPPQGYRQGSGESNLEKKERLYSQMCATREKNLMGDQEQLKIQVTQLEEEVGTLRKINKGLFDFSSRLIMKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8H1</accession>
    <name>A0A670K8H1_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TSSK4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028559211.1">
        <property type="nucleotide sequence ID" value="XM_028703378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K8H1"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034603.1">
        <property type="protein sequence ID" value="ENSPMRP00000032630.1"/>
        <property type="gene ID" value="ENSPMRG00000021147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114582389"/>
    <dbReference type="KEGG" id="pmua:114582389"/>
    <dbReference type="CTD" id="283629"/>
    <dbReference type="GeneTree" id="ENSGT00940000164769"/>
    <dbReference type="OMA" id="EDPWYSP"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000658">
        <property type="entry name" value="Protein CBG12184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF56">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MARK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="314" mass="35521" checksum="EDF8A5531538BFD3" modified="2020-06-17" version="1">MVAIKIISKKKASEDYLTKFLPREIQVMKTLRHKYVISFYQAIETTSRHYIIMELAPCGDVLEWIQKSGACSEALAGKWFSQLSLGIAYLHGKGIVHRDLKLENLLLDKRENIKISDFGFSKMVSTQTQPPPTPSYRMMSCFSHLSQTYCGSFAYACPEILLGLPYNPFLSDIWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVSFPSHLQINEEIKELVHRILRPASKRLNILEVLKVPWVLKFLAEKPTTEIKALEAICGPRAADTSKNATTPSTTKSRSLTFTPDKKKAASRTRSTGQIKGTKTQEKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670K8M4</accession>
    <name>A0A670K8M4_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LPIN3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27429"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27430"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028590837.1">
        <property type="nucleotide sequence ID" value="XM_028735004.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028590838.1">
        <property type="nucleotide sequence ID" value="XM_028735005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670K8M4"/>
    <dbReference type="Ensembl" id="ENSPMRT00000035154.1">
        <property type="protein sequence ID" value="ENSPMRP00000033136.1"/>
        <property type="gene ID" value="ENSPMRG00000021485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114599556"/>
    <dbReference type="KEGG" id="pmua:114599556"/>
    <dbReference type="CTD" id="64900"/>
    <dbReference type="GeneTree" id="ENSGT00940000160046"/>
    <dbReference type="OMA" id="GSRWWFS"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF62">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE LPIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="7">
        <location>
            <begin position="694"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000033136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="906" mass="100042" checksum="2E82D02985F6D0EB" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KA85</accession>
    <name>A0A670KA85_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid amide hydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAAH2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KA85"/>
    <dbReference type="Ensembl" id="ENSPMRT00000033652.1">
        <property type="protein sequence ID" value="ENSPMRP00000031727.1"/>
        <property type="gene ID" value="ENSPMRG00000020556.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162502"/>
    <dbReference type="OMA" id="LPTTWGM"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
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        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF4">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000031727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="622" mass="67451" checksum="CCF5EF6B6FFE23E7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KC05</accession>
    <name>A0A670KC05_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028568782.1">
        <property type="nucleotide sequence ID" value="XM_028712949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A670KC05"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034304.1">
        <property type="protein sequence ID" value="ENSPMRP00000032347.1"/>
        <property type="gene ID" value="ENSPMRG00000020962.1"/>
    </dbReference>
    <dbReference type="GeneID" id="114588032"/>
    <dbReference type="KEGG" id="pmua:114588032"/>
    <dbReference type="CTD" id="6194"/>
    <dbReference type="GeneTree" id="ENSGT00390000009819"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2650:FF:000001">
        <property type="entry name" value="40S ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="249" mass="28713" checksum="547CCE0DF5D30619" modified="2020-06-17" version="1">MKLNISFPATGCQKLIEVDDERKLRTFYEKRMTTEVSADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTQKNKDEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCQ9</accession>
    <name>A0A670KCQ9_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KCQ9"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036222.1">
        <property type="protein sequence ID" value="ENSPMRP00000034155.1"/>
        <property type="gene ID" value="ENSPMRG00000022156.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162179"/>
    <dbReference type="OMA" id="HTKVTPH"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000806">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="430" mass="48466" checksum="6CEAA0EC5780FAC8" modified="2020-06-17" version="1">MILPPRQGLPFPPPLPRVAAAAARISAGEEDDGQNSTEPSVNSLGRTKKQFKCKECGMCFRPFGRLRIHQQTHTGENPCKYMECEKNFSESGNLRIHQQNHNGEKPFKCTECGKSLSSSGALRTHQRTHTGEKPFECIECGKSFRENAALRTHQRTHTGEKPFQCTECGKSFSHSGSLRTHQRTHTGEKPFECTECGKSFSHSGSLRTHQRTHTGEKPFECTECGKSFSHSGSLRTHQRTHTGEKPFECIQCGKSLASSGALRTHQRTHTGEKPFECIECGKSFSESQSLEYINELTQGRNHLNALNVERASDRMEPLEHINKLTQGRNHLFALNVERASVVVKGLEQHQRTHTGEKPFECIECGKSFSRSDSLRTHQRTHTGEKPFECIECGKSFSRSGDLRTHQRTHTVEKPFECIECGKSFRQKCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KCU0</accession>
    <name>A0A670KCU0_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LYRM9</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family. LYRM9 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A670KCU0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036754.1">
        <property type="protein sequence ID" value="ENSPMRP00000034651.1"/>
        <property type="gene ID" value="ENSPMRG00000022457.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002625"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd20269">
        <property type="entry name" value="Complex1_LYR_LYRM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045291">
        <property type="entry name" value="Complex1_LYR_LYRM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052151">
        <property type="entry name" value="Complex_I_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47061">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47061:SF1">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="4">
        <location>
            <begin position="50"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000034651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="121" mass="13926" checksum="06712D43B0D9D53C" modified="2020-06-17" version="1">MPPRISPRISRRHRALHPGPDLGLMKPLATEGAERSQAMAPLPGAELVKSPLQLYRYLLRCCKLLPGKNVQEHYKHMIRQSFHVHADEDNPERIRQIIKRSIEDADWVMEKVSIPCSFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KD10</accession>
    <name>A0A670KD10_PODMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase</fullName>
            <ecNumber evidence="5">3.5.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">N-glycanase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Peptide:N-glycanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NGLY1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.</text>
            <dbReference type="EC" id="3.5.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.52" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A670KD10"/>
    <dbReference type="Ensembl" id="ENSPMRT00000034680.1">
        <property type="protein sequence ID" value="ENSPMRP00000032707.1"/>
        <property type="gene ID" value="ENSPMRG00000021142.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006540"/>
    <dbReference type="OMA" id="DLQDVTW"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1020:FF:000001">
        <property type="entry name" value="Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1020">
        <property type="entry name" value="Peptide N glycanase, PAW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038680">
        <property type="entry name" value="PAW_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006588">
        <property type="entry name" value="Peptide_N_glycanase_PAW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04721">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00613">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51398">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PAW" evidence="16">
        <location>
            <begin position="391"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSPMRP00000032707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000472272"/>
        </source>
    </evidence>
    <sequence length="590" mass="68170" checksum="37E2ADF79C9683D7" modified="2020-06-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-06-17" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A670KDG0</accession>
    <name>A0A670KDG0_PODMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Podarcis muralis</name>
        <name type="common">Wall lizard</name>
        <name type="synonym">Lacerta muralis</name>
        <dbReference type="NCBI Taxonomy" id="64176"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Lepidosauria</taxon>
            <taxon>Squamata</taxon>
            <taxon>Bifurcata</taxon>
            <taxon>Unidentata</taxon>
            <taxon>Episquamata</taxon>
            <taxon>Laterata</taxon>
            <taxon>Lacertibaenia</taxon>
            <taxon>Lacertidae</taxon>
            <taxon>Podarcis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="5633" last="5642">
            <title>Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.</title>
            <authorList>
                <person name="Andrade P."/>
                <person name="Pinho C."/>
                <person name="Perez I de Lanuza G."/>
                <person name="Afonso S."/>
                <person name="Brejcha J."/>
                <person name="Rubin C.J."/>
                <person name="Wallerman O."/>
                <person name="Pereira P."/>
                <person name="Sabatino S.J."/>
                <person name="Bellati A."/>
                <person name="Pellitteri-Rosa D."/>
                <person name="Bosakova Z."/>
                <person name="Bunikis I."/>
                <person name="Carretero M.A."/>
                <person name="Feiner N."/>
                <person name="Marsik P."/>
                <person name="Pauperio F."/>
                <person name="Salvi D."/>
                <person name="Soler L."/>
                <person name="While G.M."/>
                <person name="Uller T."/>
                <person name="Font E."/>
                <person name="Andersson L."/>
                <person name="Carneiro M."/>
            </authorList>
            <dbReference type="PubMed" id="30819892"/>
            <dbReference type="DOI" id="10.1073/pnas.1820320116"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A670KDG0"/>
    <dbReference type="Ensembl" id="ENSPMRT00000036994.1">
        <property type="protein sequence ID" value="ENSPMRP00000034886.1"/>
        <property type="gene ID" value="ENSPMRG00000022583.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016757"/>
    <dbReference type="OMA" id="ICITQSA"/>
    <dbReference type="Proteomes" id="UP000472272">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence